Plural Hetero Rings Patents (Class 549/448)
  • Patent number: 4602033
    Abstract: Aryl N-oxalyl-N-methyl-carbamates of the general formula ##STR1## in which X represents an alkoxy, alkenoxy, alkinoxy, aryloxy, alkylthio, alkenylthio, alkinylthio or arylthio radical, each of which may be optionally substituted or represents a radical of the general formula --N R.sup.3 R.sup.4, wherein R.sup.3 and R.sup.4 are identical or different and represent a hydrogen atom or an alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl or aryl radical, each of which may be optionally substituted, or the radicals R.sup.3 and R.sup.4, together with the N atom to which they are bonded, form an optionally substituted heterocyclic ring, andR.sup.1 represents an aryl radical which is optionally substituted,are novel and find use as pesticides, especially for combating insects, acarids and nematodes.
    Type: Grant
    Filed: January 3, 1985
    Date of Patent: July 22, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gerhard Heywang, Engelbert Kuhle, Wolfgang Behrenz, Ingeborg Hammann, Bernhard Homeyer
  • Patent number: 4575560
    Abstract: The invention is insecticidal diaminoguanidine hydrazone compounds which are also effective antifeeding agents for insects and methods for their preparation.
    Type: Grant
    Filed: February 25, 1985
    Date of Patent: March 11, 1986
    Assignee: American Cyanamid Company
    Inventors: Roger W. Addor, Donald P. Wright, Jr., Jack K. Siddens, John J. Hand
  • Patent number: 4564479
    Abstract: Compounds of the formula I ##STR1## in which A is C.sub.2-12 -alkenyl, C.sub.4-8 -cycloalkenyl or a grouping--C(R).dbd.C(R')--Y and Y, R, R', R.sub.1, R.sub.2, R.sub.3 and R.sub.3 ' are as defined in patent claim 1, can be prepared in high yields in a simple and economical manner by reacting corresponding bromobenzenes or iodobenzenes with a compound HA in the presence of an alkali metal salt or alkaline earth metal salt of an aliphatic monocarboxylic acid having 1-12 C atoms or benzoic acid, of a cyclic or N,N-disubstituted amide as the solvent, particularly N,N-dimethylformamide, and of a palladium compound which can, if desired, contain arsenic or phosphorus, as the catalyst.
    Type: Grant
    Filed: October 29, 1982
    Date of Patent: January 14, 1986
    Assignee: Ciba-Geigy Corporation
    Inventor: Alwyn Spencer
  • Patent number: 4551472
    Abstract: Unsymmetrical N-substituted bis-carbamoyl sulfide compounds exhibit exceptional broad spectrum pesticidal activity coupled with extremely low mammalian toxicity and phytotoxicity.
    Type: Grant
    Filed: January 9, 1984
    Date of Patent: November 5, 1985
    Assignee: Union Carbide Corporation
    Inventor: Themistocles D. J. D'Silva
  • Patent number: 4540799
    Abstract: Perfluoro(2,2-dimethyl-1,3-dioxole) forms oligomers on standing in the presence of an ether. The preferred ethers are aliphatic and cycloaliphatic, especially tetrahydrofuran. Free radical generators, especially peroxydicarbonates, may be added to the reaction medium. The oligomers have a degree of polymerization of about 2-8. They are useful as lubricants, hydraulic fluids, heat transfer agents, and plasticizers, and as intermediates to oligomeric acid fluorides and acids, which acids are useful surfactants.
    Type: Grant
    Filed: June 11, 1984
    Date of Patent: September 10, 1985
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Edward N. Squire
  • Patent number: 4537980
    Abstract: A new method for the preparation of acetals of long chain fatty aliphatic aldehydes and polyols containing four or more hydroxyl groups which produces the acetals in a relatively pure form by reaction in a mutual solvent, preferably a C.sub.1 to C.sub.4 fatty carboxylic acid. The `clean` acetals are useful emulsifying agents and their esters and polyalkoxy substituents are useful dispersants and surfactants for aqueous compositions.
    Type: Grant
    Filed: December 23, 1983
    Date of Patent: August 27, 1985
    Assignee: Imperial Chemical Industries Limited
    Inventor: James N. Greenshields
  • Patent number: 4528388
    Abstract: Xanthogen disulphides of the following formula: ##STR1## wherein R and R.sub.1 independently represent hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.5 -C.sub.8 -cycloalkyl or an oxygen-containing heterocyclic ring system having from 5 to 8 ring members and optionally mono- or tri-substituted by C.sub.1 -C.sub.4 -alkyl, and whereinR and R.sub.1 may also be connected together to complete a hetero cyclic ring having from 3 to 6 carbon atoms and from 1 to 3 oxygen ring members, and the ring may be substituted by from 1 to 3 C.sub.1 -C.sub.4 -alkyl groups, with a content of elemental sulphur of less than 1.7% by weight, a process for their production by the reaction of a xanthic acid-O-ester-alkali metal salt of the following formula: ##STR2## wherein R and R.sub.1 are as defined in claims 1 and 3, andM represents an alkali metal, with aqueous chlorine bleach liquor, characterized in that aqueous chlorine bleach liquor having a concentration of less than 0.
    Type: Grant
    Filed: November 23, 1981
    Date of Patent: July 9, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gunter Arend, Heinrich Konigshofen, Peter Muller, Rudiger Musch
  • Patent number: 4521539
    Abstract: Tetrahydrofuranyl substituted ethers are provided having the structural formula ##STR1## wherein A is (CH.sub.2).sub.2, CH.dbd.CH or a single bond, m is 1 to 5, B is a single bond or CH.dbd.CH, n is 1 to 4, X is O or ##STR2## wherein n' is 0, 1 or 2, R is H, lower alkyl or alkali metal and R.sup.1 is lower alkyl, arylalkyl, aryl, cycloalkyl, cycloalkylalkyl or lower alkenyl and including all stereoisomers thereof.The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease and as antiinflammatory agents and analgesics.
    Type: Grant
    Filed: May 10, 1984
    Date of Patent: June 4, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Jagabandhu Das
  • Patent number: 4507292
    Abstract: Aryl N-oxalyl-N-methyl-carbamates of the general formula ##STR1## in which X represents an alkoxy, alkenoxy, alkinoxy, aryloxy, alkylthio, alkenylthio, alkinylthio or arylthio radical, each of which may be optionally substituted, or represents a radical of the general formula --N R.sup.3 R.sup.4, wherein R.sup.3 and R.sup.4 are identical or different and represent a hydrogen atom or an alkyl, alkenyl, alkinyl, cycloalkyl, cycloalkenyl or aryl radical, each of which may be optionally substituted,or the radicals R.sup.3 and R.sup.4, together with the N atom to which they are bonded, form an optionally substituted heterocyclic ring, andR.sup.1 represents an aryl radical which is optionally substituted,are novel and find use as pesticides, especially for combating insects, acarids and nematodes.
    Type: Grant
    Filed: January 27, 1983
    Date of Patent: March 26, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gerhard Heywang, Engelbert Kuhle, Wolfgang Behrenz, Ingeborg Hammann, Bernhard Homeyer
  • Patent number: 4496721
    Abstract: Symmetrical N-substituted bis-carbamoyl sulfide compounds exhibit exceptional broad spectrum pesticidal activity coupled with extremely low mammalian toxicity and phytotoxicity.
    Type: Grant
    Filed: February 7, 1983
    Date of Patent: January 29, 1985
    Assignee: Union Carbide Corporation
    Inventor: Themistocles D. J. D'Silva
  • Patent number: 4496749
    Abstract: Perfluoro(2,2-dimethyl-1,3-dioxole) forms oligomers on standing in the presence of an ether. The preferred ethers are aliphatic and cycloaliphatic, especially tetrahydrofuran. Free radical generators, especially peroxydicarbonates, may be added to the reaction medium. The oligomers have a degree of polymerization of about 2-8. They are useful as lubricants, hydraulic fluids, heat transfer agents, and plasticizers, and as intermediates to oligomeric acid fluorides and acids, which acids are useful surfactants.
    Type: Grant
    Filed: September 23, 1982
    Date of Patent: January 29, 1985
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Edward N. Squire
  • Patent number: 4495199
    Abstract: A new dioxolanic amine is disclosed, with pharmacological activity of the following structural formula I: ##STR1## as well as its pharmaceutically acceptable salts, possessing intense vasodilatory, anti-angina and anti-arrhythmic activity, accompanied by a low toxicity; its method of preparation; pharmaceutical compositions containing the said compounds; and the treatment and prevention various pathological conditions with the use of said compositions. Also disclosed are new dioxolanic compound of the following structural formula II: ##STR2## which is an intermediate compound in the preparation of the formula I compound; and its method of preparation.
    Type: Grant
    Filed: September 30, 1982
    Date of Patent: January 22, 1985
    Inventors: Jose Miguel B. Ribalta, Leonida Bruseghini, Silvano Casadio, Jorge P. Iniesta
  • Patent number: 4482730
    Abstract: The synthesis of C-4 alkyl homologs of racemic (1RS,4SR,5RS)-4-(4,8-dimethyl-5-hydroxy-7-nonenyl)-4-methyl-3,8-dioxabicyc lo[3.2.1]octane-1-acetic acid and the corresponding (1RS,4RS,5RS) - derivative is described. The dioxabicylo[3.2.1]octanes are useful as contragestational agents.
    Type: Grant
    Filed: March 16, 1983
    Date of Patent: November 13, 1984
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Zoltan G. Hajos, Michael P. Wachter
  • Patent number: 4474596
    Abstract: The invention concerns new xylite derivatives, methods for the production of these compounds as well as compositions containing them having growth regulatory activity for plants.
    Type: Grant
    Filed: May 19, 1982
    Date of Patent: October 2, 1984
    Assignee: Schering Aktiengesellschaft
    Inventors: Hans-Rudolf Kruger, Reinhold Puttner, Hansjorg Krahmer, Ernst A. Pieroh
  • Patent number: 4459418
    Abstract: A new method for the preparation of acetals of long chain fatty aliphatic aldehydes and polyols containing four or more hydroxyl groups which produces the acetals in a relatively pure form by reaction in a mutual solvent, preferably a C.sub.1 to C.sub.4 fatty carboxylic acid. The `clean` acetals are useful emulsifying agents and their esters and polyalkoxy substituents are useful dispersants and surfactants for aqueous compositions.
    Type: Grant
    Filed: April 15, 1980
    Date of Patent: July 10, 1984
    Assignee: Imperial Chemical Industries
    Inventor: James N. Greenshields
  • Patent number: 4450217
    Abstract: Novel chalcogenopentalene compounds having a tellurium atom in the 6a position, and methods of making chalcogenopentalenes having a tellurium or a selenium atom in the 6a position are disclosed. The chalcogenopentalene compounds are useful as sensitizers in electrophotographic compositions and elements containing an electron donor and as charge emitters in multilayer photoconductive elements.
    Type: Grant
    Filed: March 15, 1983
    Date of Patent: May 22, 1984
    Assignee: Eastman Kodak Company
    Inventors: Michael R. Detty, Jerome H. Perlstein
  • Patent number: 4448773
    Abstract: Compounds of the formula ##STR1## in which Ar is 2-alkyl-, -alkoxy- or -halo-methyl-phenyl or .alpha.-naphthyl, each of which is further substituted,R.sub.1 is 2-furyl, 2-tetrahydrofuryl, alkenyl, cyclopropyl, .beta.-alkoxyethyl, hydroxymethyl, triazolylmethyl, imidazolylmethyl, pyrazolylmethyl, alkylsulfinyl, alkylsulfonyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkenylthio, alkynylthio, alkylsulfinyloxy, dialkylaminosulfinyloxy, phosphoric or thiophosphoric esters or amides, or alkylcarbonyloxy,R.sub.7 is hydrogen or optionally-substituted methyl or ethyl, andR.sub.8 is alkyl optionally substituted by alkoxy,are microbicidally, in particular fungicidally, active. Preferred compounds are those in which Ar is 2-methylphenyl, 2-methoxyphenyl, 2-chlorophenyl or .alpha.-naphthyl, each of which is further substituted by azido, and each of R.sub.7 and R.sub.8 is methyl.
    Type: Grant
    Filed: April 22, 1982
    Date of Patent: May 15, 1984
    Assignee: Ciba-Geigy Corporation
    Inventors: Peter Riebli, Hanspeter Fischer, Rudolph C. Thummel, Adolf Hubele
  • Patent number: 4430336
    Abstract: N-Substituted 2-methylnaphthylamides of the general formula ##STR1## where R.sup.1 is ##STR2## R.sup.3 being hydrogen or alkoxy, or R.sup.1 is ##STR3## R.sup.4 and R.sup.5 being unsubstituted or substituted alkyl, or R.sup.4 and R.sup.5 together forming a heterocyclic ring which contains two oxygen atoms and is unsubstituted or substituted by alkyl or aryl,R.sup.2 is alkyl which is unsubstituted or substituted by halogen, alkoxy, imidazolyl, pyrazolyl or oxo (.dbd.O), or is alkenyl, alkynyl, cycloalkenyl or alkoxy, or substituted or unsubstituted phenyl, or substituted or unsubstituted hetaryl andX is hydrogen, methyl or halogen, fungicides containing these compounds, and processes for the preparation of the compounds.
    Type: Grant
    Filed: November 18, 1980
    Date of Patent: February 7, 1984
    Assignee: BASF Aktiengesellschaft
    Inventors: Costin Rentzea, Bernd Zeeh, Ernst-Heinrich Pommer
  • Patent number: 4414401
    Abstract: A process is provided for separating and recovering solid, metal catalysts from reaction mixtures in which they are dispersed, with cross-flow filtration using membrane separation devices. The process is particularly useful for separating gelatinous catalyst sludges, e.g., nickel hydroxide, used in oxidizing diacetone sorbose.
    Type: Grant
    Filed: October 29, 1981
    Date of Patent: November 8, 1983
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Willi Wintermeyer, Rolf Wittmann, Jurgen Butzke
  • Patent number: 4410543
    Abstract: Carboxylated oxime-carbamates of the formula ##STR1## in which R.sub.1 represents a substituted or unsubstituted phenyl, naphthyl or dihydrobenzofuranyl radical and R.sub.2 and R.sub.3 independently of one another represent hydrogen or C.sub.1 -C.sub.4 -alkyl.A process for the preparation of these carboxylated oxime-carbamates, and their use in controlling pests, are described.
    Type: Grant
    Filed: March 19, 1982
    Date of Patent: October 18, 1983
    Assignee: Ciba-Geigy Corporation
    Inventor: Jozef Drabek
  • Patent number: 4409393
    Abstract: Perfluoro(2,2-dimethyl-1,3-dioxole) forms oligomers on standing in the presence of an ether. The preferred ethers are aliphatic and cycloaliphatic, especially tetrahydrofuran. Free radical generators, especially peroxydicarbonates, may be added to the reaction medium. The oligomers have a degree of polymerization of about 2-8. They are useful as lubricants, hydraulic fluids, heat transfer agents, and plasticizers, and as intermediates to oligomeric acid fluorides and acids, which acids are useful surfactants.
    Type: Grant
    Filed: July 2, 1981
    Date of Patent: October 11, 1983
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Edward N. Squire
  • Patent number: 4399294
    Abstract: Ranitidine is prepared by treating an aldehyde of formula (II) ##STR1## with dimethylamine and a reducing agent which is capable of effecting reductive alkylation to introduce the group Me.sub.2 NCH.sub.2 -- but which does not reduce the nitroethene group. The reaction is carried out in a suitable solvent, preferably in the presence of an acid or followed by treatment with an acid. Suitable reducing agents include, diborane, aluminium hydride and alkali or alkaline earth metal borohydrides.The aldehyde (II) may be generated in situ from an acetal of formula (III) ##STR2## where R.sub.1 and R.sub.2 are both alkyl groups or R.sub.1 OCHOR.sub.2 forms a cyclic acetal.
    Type: Grant
    Filed: December 30, 1981
    Date of Patent: August 16, 1983
    Assignee: Glaxo Group Limited
    Inventors: David E. Bays, John W. Clitherow, Duncan B. Judd
  • Patent number: 4390711
    Abstract: This disclosure describes certain 6,9.alpha.-epoxy prostacyclines and their intermediates. These compounds are useful as bronchodilators and inflammatory mediator release inhibitors.
    Type: Grant
    Filed: November 13, 1980
    Date of Patent: June 28, 1983
    Assignee: American Cyanamid Company
    Inventors: Charles V. Grudzinskas, Sow-Mei L. Chen, Allan Wissner
  • Patent number: 4386101
    Abstract: Unsymmetrical bis-carbamates of the formula ##STR1## wherein R.sub.1 is a phenyl, dihydrobenzofuranyl, naphthyl, pyrimidyl, pyrazolyl, triazolyl, quinolinyl or tetrahydroquinolinyl group, andR.sub.2 is a benzyl group,processes for producing them and their use for combating pests are described.
    Type: Grant
    Filed: November 9, 1981
    Date of Patent: May 31, 1983
    Assignee: Ciba-Geigy Corporation
    Inventors: Jozef Drabek, Manfred Boger
  • Patent number: 4382956
    Abstract: N-Sulphenylated biurets of the formula ##STR1## in which R.sup.1 represents a trihalogenomethyl radical,R.sup.2 represents an optionally substituted aliphatic, cycloaliphatic, araliphatic or aromatic radical andR.sup.3 and R.sup.4 are identical or different and represent a hydrogen atom, an optionally substituted aliphatic, cycloaliphatic, araliphatic, aromatic or heterocyclic radical or the amino or hydroxyl group, or together with the connecting nitrogen atom represent a five-membered or six-membered heterocyclic ring, the ring carbon atoms of which are optionally interrupted by one or more further hetero-atoms,which possess fungicidal activity.
    Type: Grant
    Filed: December 15, 1981
    Date of Patent: May 10, 1983
    Assignee: Bayer Aktiengesellschaft
    Inventors: Engelbert Kuhle, Volker Paul, Wilhelm Brandes
  • Patent number: 4350824
    Abstract: A process for the preparation of a 1,1-dichloroalkene of the formula ##STR1## in which R.sup.1 is hydrogen, or an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, aralkenyl or aryl radical, andR.sup.2 is an optionally substituted alkyl, alkenyl, alkinyl, cycloalkyl, aralkyl, aralkenyl or aryl radical, orR.sup.1 and R.sup.2 together form an optionally branched and/or optionally benzo-fused hydrocarbon chain,comprising reacting a carbonyl compound of the formula ##STR2## with a trichloromethanephosphonic acid ester of the formula ##STR3## in which R.sup.3 each individually is an alkyl or phenyl radical, or the two radicals R.sup.3 together are alkanediyl,in the presence of at least an equimolar amount of a phosphorous acid triamide of the formulaP(NR.sup.4.sub.2).sub.3in whichR.sup.4 each independently is an alkyl radical, or the two radicals R.sup.4 together are alkanediyl.Advantageously,R.sup.1 is hydrogen,R.sup.2 a C.sub.2 to C.sub.
    Type: Grant
    Filed: February 23, 1981
    Date of Patent: September 21, 1982
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hans-Jochem Riebel, Fritz Maurer, Uwe Priesnitz
  • Patent number: 4335055
    Abstract: Compounds of the formula I ##STR1## in which Z, Z.sub.1, R, m and p are as defined in patent claim 1, can be obtained in a simple and economical manner by a novel process wherein a halide of the formula II ##STR2## is reacted with a substituted or unsubstituted vinylbenzene or vinylnaphthalene derivative in the presence of a base and of certain palladium catalysts, such as palladium acetate. The compounds (I) or functional derivatives preparable therefrom are useful, for example, for the preparation of known dyes or fluorescent brighteners, or can be used directly as fluorescent brighteners or as scintillators.
    Type: Grant
    Filed: May 8, 1981
    Date of Patent: June 15, 1982
    Assignee: Ciba-Geigy Corporation
    Inventors: Hans-Ulrich Blaser, Dieter Reinehr, Alwyn Spencer
  • Patent number: 4329473
    Abstract: This invention relates to novel analogs of proline terminal tripeptides and related compounds and is typified by ##STR1## The compounds are potent inhibitors of angiotensin converting enzyme and as such are useful as antihypertensive agents.
    Type: Grant
    Filed: December 24, 1980
    Date of Patent: May 11, 1982
    Inventors: Ronald G. Almquist, Joseph I. De Graw