The Chalcogen, X, Is In A -c(=x)- Group Patents (Class 549/454)
  • Patent number: 10227321
    Abstract: The invention relates to a compound of general formula (I) (in configuration Z or E) and to pro-pheromonal compositions and formulations comprising said compound, in addition to the uses thereof for soothing purposes for non-human mammals such as sheep, pigs, sheep, cattle, felines, equines and canines.
    Type: Grant
    Filed: December 24, 2015
    Date of Patent: March 12, 2019
    Assignee: Melchior Material And Life Science France
    Inventors: Olivier Guerret, Loic Guilonneau, Samuel Dufour
  • Patent number: 9663531
    Abstract: The present invention relates to a process for preparing sordidin, comprising a step of preparing 4-(2-ethyl-1,3-dioxolan-2-yl)pentan-2-one by means of a reaction in which 2-ethyl-2-(pent-4-en-2-yl)-1,3-dioxolane is oxidized in the presence of a catalyst chosen from the group comprising organometallic complexes of transition metals.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: May 30, 2017
    Assignees: M2I DEVELOPMENT, M2I SALIN
    Inventors: Samuel Dufour, Valérie LeJeune, Hubert Sevestre
  • Publication number: 20150119586
    Abstract: To provide an industrial method for producing a substituted benzoic acid compound useful as an intermediate of pharmaceutical and agricultural chemicals with high purity and high yield.
    Type: Application
    Filed: April 30, 2013
    Publication date: April 30, 2015
    Applicant: ISHIHARA SANGYO KAISHA, LTD.
    Inventors: Hisayoshi Jonishi, Tomohiro Okamoto, Norio Adachi, Akihiko Isogai, Tatsuya Jukurogi, Hideaki Konishi, Fumihiro Fukui
  • Publication number: 20150080585
    Abstract: A method for producing a product that comprises glycerol ketal of ethyl levulinate or propylene glycol ketal of ethyl levulinate comprises reacting either glycerol or propylene glycol with ethyl levulinate in the presence of a homogenous or heterogeneous catalyst system in a reactor system. The ethyl levulinate and either glycerol or propylene glycol are heated to remove water, polyol, and excess ethyl levulinate. The excess ethyl levulinate and polyol is recycled back to the reactor. The product is distilled in a specific fashion and optionally treated by means of a stabilizing agent or acid species removal bed, to obtain a composition comprising glycerol ketal of ethyl levulinate or propylene glycol ketal of ethyl levulinate wherein the composition comprises less than or equal to about 2 wt % contaminants.
    Type: Application
    Filed: November 21, 2014
    Publication date: March 19, 2015
    Inventors: BRIAN D. MULLEN, MARC D. SCHOLTEN, ANDREW J. LOUWAGIE, STEVEN A. DONEN, FENG JING, VIVEK BADARINARAYANA
  • Publication number: 20150076402
    Abstract: A dioxolane derivative represented by formula (G1) is provided. The explanation of the substituents is given in the specification. The use of the dioxolane derivative enables the production of a liquid crystal composition and a liquid crystal display device including the liquid crystal composition.
    Type: Application
    Filed: July 30, 2014
    Publication date: March 19, 2015
    Inventors: Momoko KATO, Yasuhiro Niikura, Tetsuji Ishitani, Yuko Kawata
  • Publication number: 20150010469
    Abstract: Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer, stereoisomer or deuterated analogue thereof, wherein X, R, R1, R2, R3, R4, M1, M2, L1, L2, J1, J2, a1, a2, b1 and b2 are as defined herein, are provided. Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided.
    Type: Application
    Filed: July 3, 2014
    Publication date: January 8, 2015
    Applicants: British Columbia Cancer Agency Branch, University of British Columbia
    Inventors: Raymond John Andersen, Javier Garcia Fernandez, Marianne Dorothy Sadar
  • Patent number: 8906961
    Abstract: The present disclosure relates to the preparation of ketal compounds from glycerol and levulinic acid and esters, and uses thereof, in particular the manufacture of polyurethanes.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: December 9, 2014
    Assignee: Segetis, Inc.
    Inventor: Sergey Selifonov
  • Publication number: 20140228339
    Abstract: There is provided a compound which is (a) a pyrimidine sulfonamide of formula (I) or (b) a pharmaceutically acceptable salt thereof, crystalline forms of the compound, processes for obtaining the compound, pharmaceutical intermediates used in the manufacture of the compound, and pharmaceutical compositions containing the compound. The compound is useful in the treatment of a disease/condition in which modulation of chemokine receptor activity is beneficial.
    Type: Application
    Filed: April 15, 2014
    Publication date: August 14, 2014
    Applicant: AstraZeneca AB
    Inventors: Stephen Connolly, Mark Richard Ebden, Iain Alastair Stewart Walters, Thomas Langer, Alan Robert Steven, Craig Robert Stewart, Paula Margaret Tomlin, Andrew John Williams
  • Publication number: 20140212441
    Abstract: The present invention relates to methods and pharmaceutical compositions for immunosuppression by using the fatty acid derivative represented by formula (I). The present invention further relates to methods and pharmaceutical compositions for treating inflammatory diseases, allergic diseases and autoimmune diseases by using said fatty acid derivative.
    Type: Application
    Filed: June 20, 2012
    Publication date: July 31, 2014
    Applicant: R-TECH UENO, LTD.
    Inventors: Yukihiko Mashima, Masahiro Tajima, Reiko Tabuchi
  • Publication number: 20140163127
    Abstract: The present disclosure relates to the preparation of acrylate, alkacrylate, allyl, and polycarbonate derivatives of hydroxy ketal esters, and uses thereof.
    Type: Application
    Filed: November 1, 2013
    Publication date: June 12, 2014
    Applicant: SEGETIS, INC.
    Inventors: Sergey SELIFONOV, Brian Daniel MULLEN, Douglas Alan WICKS, Vivek BADARINARAYANA
  • Publication number: 20140155635
    Abstract: Disclosed are a novel resorcyclic acid lactone compound with inhibitory activity against protein kinases, a pharmaceutically acceptable salt thereof, a method for the synthesis thereof, and a pharmaceutical composition for the treatment and prevention of various cancer diseases comprising the same as an active ingredient. The novel resorcyclic acid lactone compound is useful as a therapeutic for cancer diseases, especially blood cancer, inter alia, acute myeloid leukemia (AML).
    Type: Application
    Filed: October 29, 2013
    Publication date: June 5, 2014
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Tae Bo SIM, Ho Jong Yoon, Ji Nyeo Kim
  • Publication number: 20140147395
    Abstract: This disclosure is directed to compound of formula (1): wherein R1 is a C7-18 alkyl, R2 is hydrogen or a C1-3 alkyl, each R3, R4, R5, R6, and R7 is independently hydrogen or a C1-6 alkyl, a is 2-3, and b is 0-1, its method of preparation and uses thereof in water-borne coating compositions, cleaning compositions, fragrance, and personal care compositions.
    Type: Application
    Filed: November 27, 2013
    Publication date: May 29, 2014
    Applicant: SEGETIS, INC.
    Inventors: Lee R. Rieth, Dorie J. Yontz
  • Patent number: 8680303
    Abstract: The present invention generally relates to methods for the synthesis of catalysts, including epoxidation catalysts, and related compounds and catalyst compositions. Embodiments described herein may provide efficient processes for providing catalysts (e.g., epoxidation catalysts) in large quantities and using simplified methods.
    Type: Grant
    Filed: February 28, 2011
    Date of Patent: March 25, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Timothy F. Jamison, Yutaka Ikeuchi
  • Patent number: 8669382
    Abstract: In the presence invention, a (2R)-2-fluoro-2-C-methyl-D-ribono-?-lactone precursor is produced in the form of a ring-opened fluorinated compound by reaction of a 1,2-diol with sulfuryl fluoride (SO2F2) in the presence of an organic base and, optionally, a fluoride ion source. The production method of the present invention secures less number of process steps as compared to the conventional production method (shortening of three steps: cyclic sulfurous esterification, oxidation and ring-opening fluorination to one step) and satisfies the requirements for industrial production (high yield and high reproductivity). The thus-obtained (2R)-2-fluoro-2-C-methyl-D-ribono-?-lactone precursor is useful as an important intermediate for the synthesis of 2?-deoxy-2?-fluoro-2?-C-methylcytidine with antivirus activity.
    Type: Grant
    Filed: April 25, 2011
    Date of Patent: March 11, 2014
    Assignee: Central Glass Company, Limited
    Inventors: Akihiro Ishii, Hirokatsu Nagura, Hideyuki Tsuruta
  • Patent number: 8642567
    Abstract: The present invention provides therapeutically active compounds and compositions as NMDA and MC receptor antagonists, which are useful in treating central nervous system disorders by over-activation of NMDA and/or MC receptors. In one aspect, the present invention provides methods of enhancing brain's cognitive function and reducing neuronal cell death in mammals and humans.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: February 4, 2014
    Assignee: The Hong Kong University of Science and Technology
    Inventors: Nancy Yuk-Yu Ip, Fanny Chui-Fun Ip, Yueqing Hu, Wen Cai Ye
  • Publication number: 20130338349
    Abstract: The present invention provides (i) processes for preparing a 2?-deoxy-2?-fluoro-2?-methyl-D-ribonolactone derivatives, (ii) conversion of intermediate lactones to nucleosides with potent anti-HCV activity, and their analogues, and (iii) methods to prepare the anti-HCV nucleosides containing the 2?-deoxy-2?-fluoro-2?-C-methyl-?-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.
    Type: Application
    Filed: June 13, 2013
    Publication date: December 19, 2013
    Inventors: Byoung-Kwon Chun, Peiyuan Wang, Jinfa Du, Suguna Rachakonda
  • Publication number: 20130338380
    Abstract: The invention described herein pertains to processes and compounds useful in the preparation of bis-tetrahydrofurans. The invention described herein also pertains to compounds useful for treating HIV infections.
    Type: Application
    Filed: November 30, 2011
    Publication date: December 19, 2013
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventors: Arun K. Ghosh, Cuthbert D. Martyr
  • Patent number: 8604223
    Abstract: The reaction of alcohols with oxocarboxylates to form acetals or ketals is catalyzed by unexpectedly low levels of protic acids. By employing low acid catalyst levels compared to amounts conventionally used, rapid formation of acetal or ketal is facilitated while the formation of oxocarboxylate esters is minimized. Further employing a significant molar excess of oxocarboxylate in conjunction with low acid catalyst level gives rise to the rapid and clean formation of acetals and ketals from oxocarboxylates and alcohols.
    Type: Grant
    Filed: April 9, 2010
    Date of Patent: December 10, 2013
    Assignee: Segetis, Inc.
    Inventors: Sergey Selifonov, Scott D. Rothstein, Brian D. Mullen
  • Publication number: 20130316906
    Abstract: The invention relates to novel compounds of the formula (I) in which R1, R2, R3, R4, R5, Y, Q and G have the meanings given above, to a plurality of processes and intermediates for their preparation and to their use as herbicides and/or pesticides. Moreover, the invention relates to selective herbicidal compositions comprising, firstly, the phenyl-substituted bicyclooctane-1,3-dione derivates and, secondly, a crop plant compatibility-improving compound. The present invention furthermore relates to increasing the activity of crop protection compositions comprising in particular phenyl-substituted bicyclooctane-1,3-dione derivates by adding ammonium salts or phosphonium salts and, if appropriate, penetrants, to the corresponding compositions, to processes for their preparation and to their use in crop protection as pesticides and/or for preventing unwanted plant growth.
    Type: Application
    Filed: October 28, 2011
    Publication date: November 28, 2013
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Alfred Angermann, Stefan Lehr, Guido Bojack, Reiner Fischer, Isolde Häuser-hahn, Ines Heinemann, Elmar Gatzweiler, Christopher Hugh Rosinger, Arnd Voerste, Dieter Feucht
  • Patent number: 8569523
    Abstract: The reaction of alcohols with oxocarboxylates to form acetals or ketals is catalyzed by unexpectedly low levels of protic acids. By employing low acid catalyst levels compared to amounts conventionally used, rapid formation of acetal or ketal is facilitated while the formation of oxocarboxylate esters is minimized. Further employing a significant molar excess of oxocarboxylate in conjunction with low acid catalyst level gives rise to the rapid and clean formation of acetals and ketals from oxocarboxylates and alcohols.
    Type: Grant
    Filed: April 9, 2010
    Date of Patent: October 29, 2013
    Assignee: Segetis, Inc.
    Inventors: Sergey Selifonov, Scott D. Rothstein, Brian D. Mullen
  • Patent number: 8492433
    Abstract: The present disclosure relates to the preparation of ketal compounds from glycerol and levulinic acid and esters, and uses thereof, in particular the manufacture of polyurethanes.
    Type: Grant
    Filed: April 12, 2012
    Date of Patent: July 23, 2013
    Assignee: Segetis, Inc.
    Inventor: Sergey Selifonov
  • Patent number: 8436042
    Abstract: The present disclosure relates to methods of preparation of compounds resulting from the reaction of levulinic esters and epoxidized unsaturated fatty acid esters. The compounds are useful as renewable biomass-based plasticizers for a variety of polymers. Mono-, di- and tri-ketal adducts formed in a reaction between alkyl esters of levulinate and epoxidized unsaturated fatty acid esters derived from vegetable oils are also disclosed.
    Type: Grant
    Filed: November 22, 2006
    Date of Patent: May 7, 2013
    Assignee: Segetis, Inc.
    Inventor: Sergey Selifonov
  • Patent number: 8420294
    Abstract: The present invention provides a salt represented by the formula (I): wherein R1 and R2 independently each represent a C1-C6 alkyl group or R1 and R2 are bonded each other to form a C5-C20 aliphatic ring together with the carbon atom to which they are bonded, R3 and R4 independently each represent a fluorine atom or a C1-C6 perfluoroalkyl group, X1 represents a C1-C17 divalent saturated hydrocarbon group in which one or more —CH2— can be replaced by —O— or —CO— and which may be substituted with one or more fluorine atoms, and Z1+ represents an organic counter ion.
    Type: Grant
    Filed: November 25, 2011
    Date of Patent: April 16, 2013
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Koji Ichikawa, Yukako Anryu, Shingo Fujita
  • Publication number: 20130046102
    Abstract: Glyceryl ether compounds prepared by the reaction of glycerol and olefin epoxides are disclosed. The compounds are renewable biomass-based surfactants useful as detergents and emulsifiers in formulations for cleaning, laundry, personal care, cosmetics, and industrial uses.
    Type: Application
    Filed: October 22, 2012
    Publication date: February 21, 2013
    Applicant: SEGETIS, INC.
    Inventor: SEGETIS, INC.
  • Publication number: 20130040926
    Abstract: There is provided a compound which is (a) a pyrimidine sulfonamide of formula (I) or (b) a pharmaceutically acceptable salt thereof, crystalline forms of the compound, processes for obtaining the compound, pharmaceutical intermediates used in the manufacture of the compound, and pharmaceutical compositions containing the compound. The compound is useful in the treatment of a disease/condition in which modulation of chemokine receptor activity is beneficial.
    Type: Application
    Filed: July 11, 2012
    Publication date: February 14, 2013
    Inventors: Stephen CONNOLLY, Mark Richard EBDEN, Iain Alastair Stewart WALTERS, Thomas LANGER, Alan Robert STEVEN, Craig Robert STEWART, Paula Margaret TOMLIN, Andrew John WILLIAMS
  • Publication number: 20130005996
    Abstract: A method for manufacturing a fatty acid derivative represented by formula (I) is provided: wherein Z1 is wherein R3 and R4 are hydrogen atom, halogen atom, lower alkyl or lower alkoxy; when R3 and R4 are lower alkoxy, R3 and R4 may be linked together to form a ring structure; which includes the step of reacting a compound of formula (II): wherein Z2 is the same as Z1; with a co-oxidizer under the presence of an azaadamantane-N-oxyl derivative.
    Type: Application
    Filed: June 29, 2012
    Publication date: January 3, 2013
    Applicant: R-TECH UENO, LTD.
    Inventors: Tatsuya MATSUKAWA, Noriyuki YAMAMOTO
  • Publication number: 20120323024
    Abstract: A ketal ester of an oxocarboxylic acid and a process to make the same, where the ketal ester is of Structure (I): wherein a is 0 or an integer from 1 to 12; n is 0 or 1; R1 is a linear alkyl, aryl, arylalkylene, or branched alkyl group with 1-18 carbon atoms; R2 and R5 can be hydrogen, C1-6 straight chain or branched alkyl, phenyl, substituted phenyl, C1-6 alkyl substituted with up to four OH groups, C1-6 alkyl, or acetyl optionally substituted hydrocarbon radicals, or R2 and R4 together with the ?-carbon form a cycloaliphatic or heterocyclic ring with 3-6 carbon atoms and 0-3 heteroatoms, provided that only one of R2 and R5 is hydrogen; R3 is a linear alkyl or branched alkyl group with 1-18 carbon atoms; and R4 is hydrogen, or an alkyl, aryl, aralkyl or branched alkyl group with 1-10 carbon atoms.
    Type: Application
    Filed: September 13, 2010
    Publication date: December 20, 2012
    Applicant: SEGETIS, INC.
    Inventors: Douglas A. Wicks, Sergey Selifonov, Marc Davis Scholten
  • Publication number: 20120135351
    Abstract: The present invention provides a salt represented by the formula (I): wherein R1 and R2 independently each represent a C1-C6 alkyl group or R1 and R2 are bonded each other to form a C5-C20 aliphatic ring together with the carbon atom to which they are bonded, R3 and R4 independently each represent a fluorine atom or a C1-C6 perfluoroalkyl group, X1 represents a C1-C17 divalent saturated hydrocarbon group in which one or more —CH2— can be replaced by —O— or —CO— and which may be substituted with one or more fluorine atoms, and Z1+ represents an organic counter ion.
    Type: Application
    Filed: November 25, 2011
    Publication date: May 31, 2012
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Koji ICHIKAWA, Yukako ANRYU, Shingo FUJITA
  • Publication number: 20120130092
    Abstract: It is possible to produce oseltamivir safely and stably in large quantities by using as a starting material tartaric acid, mannitol or arabinose, via dihydroxyhexenoic acid ester of the formula (4c).
    Type: Application
    Filed: December 6, 2011
    Publication date: May 24, 2012
    Inventors: Teruhiko Ishikawa, Seiki Saito, Takayuki Kudoh, Kotaro Suto, Hironori Nishiuchi, Makoto Okada, Masatoshi Taniguchi
  • Publication number: 20120121911
    Abstract: Disclosed herein is a polyhydroxy ketal adduct obtained by the esterification of a hydrocarbon polyol by at least 1.5 equivalents of a ketocarboxy to produce an intermediate ketocarboxylic ester. The intermediate polyketocarboxylic ester is then ketalized to produce the polyhydroxyketal adduct, which can be used to provide a polymeric composition.
    Type: Application
    Filed: November 11, 2011
    Publication date: May 17, 2012
    Applicant: SEGETIS, INC.
    Inventors: Brian D. Mullen, Marc D. Scholten, Dorie J. Yontz, Cora M. Leibig, Matthew J. Tjosaas
  • Publication number: 20120122745
    Abstract: Various esterified alkyl ketal ester or hydroxyalkyl ketal ester products are useful as components of organic polymer compositions. The ketal esters are produced in certain transesterifications between alkyl ketal esters and/or hydroxyalkyl ketal esters and polyols, aminoalcohols, polyamines and/or polycarboxylic acids. The products are excellent plasticizers for a variety of organic polymers, notable poly(vinyl chloride) plastisols. The products are also very good lubricants for many lubrication applications.
    Type: Application
    Filed: December 21, 2011
    Publication date: May 17, 2012
    Applicant: SEGETIS, INC.
    Inventors: Brian D. MULLEN, Chunyong WU, Tara J. MULLEN, Marc D. SCHOLTEN, Vivek BADARINARAYANA
  • Patent number: 8178665
    Abstract: A process for the production of 1-(4-3(R)-[3(S)-(4-fluorophenyl)-3-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone (ezetimibe) according to the following reaction scheme: (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX), (X), (XI) where the substances of the general Formulas II, IV, VI, VIII, IX, X and XI are new, Formula III is a non-isolated intermediate, R1, R2 and R3 are represented by the compounds of Formulas Va-Vd, (Va), (Vb), (Vc), (Vd) and R4 is a silyl, e.g., tert-butyl-dimethyl-silyl, tert-butyl-diphenyl-silyl group.
    Type: Grant
    Filed: December 18, 2006
    Date of Patent: May 15, 2012
    Assignee: Richter Gedeon Nyrt.
    Inventors: József Bódi, János Éles, Katalin Szöke, Krisztina Vukics, Tamás Gáti, Krisztina Temesvári, Dorottya Kiss-Bartos
  • Publication number: 20120035376
    Abstract: A method for producing a product that comprises glycerol ketal of ethyl levulinate or propylene glycol ketal of ethyl levulinate comprises reacting either glycerol or propylene glycol with ethyl levulinate in the presence of a homogenous or heterogeneous catalyst system in a reactor system. The ethyl levulinate and either glycerol or propylene glycol are heated to remove water, polyol, and excess ethyl levulinate. The excess ethyl levulinate and polyol is recycled back to the reactor. The product is distilled in a specific fashion and optionally treated by means of a stabilizing agent or acid species removal bed, to obtain a composition comprising glycerol ketal of ethyl levulinate or propylene glycol ketal of ethyl levulinate wherein the composition comprises less than or equal to about 2 wt % contaminants.
    Type: Application
    Filed: August 3, 2011
    Publication date: February 9, 2012
    Applicant: SEGETIS, INC.
    Inventors: Brian D. Mullen, Marc D. Scholten, Andrew J. Louwagie, Steven A. Donen, Feng Jing, Vivek Badarinarayana
  • Publication number: 20120035053
    Abstract: Cyclohexanedione compounds, which are suitable for use as herbicides.
    Type: Application
    Filed: September 23, 2009
    Publication date: February 9, 2012
    Applicant: SYNGENTA CROP PROTECTION LLC
    Inventors: Christopher John Mathews, John Martin Clough, Kevin Beautement, Melloney Tyte, Louisa Robinson, Stephane André Marie Jeanmart
  • Publication number: 20120022276
    Abstract: The invention relates to a method for producing aldehyde functional compounds by a cross-metathesis reaction of an olefinic compound having at least one hydroxy group and at least one C—C double bond with at least one at least monounsaturated fatty acid or at least one at least monounsaturated fatty acid derivative, in the presence of a metathesis catalyst at a maximum temperature of 180° C. and in the presence of at least one reagent that acts as a protective group-forming compound in relation to the aldehyde group of the aldehyde functional compounds.
    Type: Application
    Filed: January 12, 2010
    Publication date: January 26, 2012
    Applicant: EVONIK DEGUSSA GmbH
    Inventors: Michael A.R. Meier, Anastasiya Rybak, Dominik Geisker, Peter Hannen, Martin Roos
  • Publication number: 20110312904
    Abstract: The present invention provides compounds of Formula (I), compositions comprising an effective amount of a compound of Formula (I), optionally with chemotherapeutic drugs such as a tubulin-binding drug, and methods of their use for reducing the toxicity of cytotoxic agents, treating or preventing cancer or a neuropathic disorder, inducing a chemoprotective phase II enzyme, DNA, or protein synthesis, enhancing the immune system, treating inflammation, improving and enhancing general health or well-being, and methods for making compounds of Formula (I).
    Type: Application
    Filed: August 27, 2009
    Publication date: December 22, 2011
    Applicants: SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH, TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Samuel J. Danishefsky, Ting-Chao Chou, Xiaoguang Lei, Heedong Yun, Fay Ng, John Hartung, Dalibor Sames
  • Publication number: 20110288315
    Abstract: A 2-aryl-2-halomethyl-4-chloromethyl-1,3-dioxolane (A) can be produced conveniently without decreasing its optical purity by reacting an optically active monochlorohydrin and an aryl (halomethyl) ketone (starting materials) with each other in the presence of an acid catalyst. From the optically active compound (A) thus produced, an optically active carboxylic acid (2-aryl-2-halomethyl-1,3-dioxolan-4-yl)methyl ester and an optically active sulfonic acid (2-aryl-2-halomethyl-1,3-dioxolan-4-yl)methyl ester (both of which are useful intermediates for the production of ketoconazole) can be produced with good efficiency. An optically active trans-carboxylic acid (2-aryl-2-halomethyl-1,3-dioxolan-4-yl)methyl ester can be isomerized into its cis-form in the presence of an acid catalyst.
    Type: Application
    Filed: March 23, 2009
    Publication date: November 24, 2011
    Applicant: DAISO CO., LTD.
    Inventors: Yutaka Ishii, Shingo Iwashina, Takahiro Kawase, Yumiko Matsui
  • Patent number: 8049032
    Abstract: A solid acid having a core of calixarene or calix resorcinarene. The solid acid is an ion conducting compound in which at least one of the hydroxyl groups is substituted by an organic group having a cation exchange group at a terminal end, a polymer electrolyte membrane including the same, and a fuel cell using the polymer electrolyte membrane. The polymer electrolyte membrane can provide low methanol crossover and high ionic conductivity. Accordingly, a fuel cell having high efficiency can be obtained by using the polymer electrolyte membrane.
    Type: Grant
    Filed: October 12, 2006
    Date of Patent: November 1, 2011
    Assignee: Samsung SDI Co., Ltd.
    Inventors: Jae-jun Lee, Myung-sup Jung, Do-yun Kim, Jin-gyu Lee, Sang-kook Mah
  • Publication number: 20110263428
    Abstract: Compounds of formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.
    Type: Application
    Filed: July 1, 2009
    Publication date: October 27, 2011
    Applicant: SYNGENTA CROP PROTECTION, INC.
    Inventors: Stephane Andre Marie Jeanmart, Russell Colin Viner, John Benjamin Taylor, William Guy Whittingham, Jeffrey Steven Wailes, Sarah Margaret Targett, Christopher John Mathews, Mangala Govenkar, Matthew Robert Cordingley, Claire Janet Russell, Melloney Tyte
  • Publication number: 20110223365
    Abstract: The present disclosure relates to the preparation of acrylate, alkacrylate, allyl, and polycarbonate derivatives of hydroxy ketal esters, and uses thereof.
    Type: Application
    Filed: September 25, 2009
    Publication date: September 15, 2011
    Applicant: SEGETIS, INC.
    Inventors: Sergey Selionov, Brian Daniel Mullen, Douglas Alan Wicks, Vivek Badarinarayana
  • Patent number: 7994346
    Abstract: This invention is directed to compounds useful as intermediates in the synthesis of lipoxin A4 analogs of the following formulas (I) and (II): wherein R1, R2, R3, R4 and R5 are described herein. These analogs are useful in treating inflammatory and autoimmune disorders in humans. These analogs are also useful in treating pulmonary or respiratory tract inflammation in humans.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: August 9, 2011
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Danja Grossbach, William Guilford, Michael Sander
  • Publication number: 20110152531
    Abstract: The present invention relates to novel acylmethylene-1,3-dioxolanes and acylmethylene-1,4-dioxanes of the general formula (I) in which R1, R2, R3 and n have the meanings given in the description, and also a novel process for their preparation. Acylmethylene-1,3-dioxolanes and acylmethylene-1,4-dioxanes are important intermediates for the preparation of pyrazoles and anthranilamides, which can be used as insecticides.
    Type: Application
    Filed: December 15, 2010
    Publication date: June 23, 2011
    Applicant: Bayer CropScience AG
    Inventors: Sergii PAZENOK, Norbert LUI, Igor GERUS, Olga BALABON
  • Publication number: 20110124690
    Abstract: The present invention relates to compositions comprising an effective amount of a Panaxytriol Compound and a tubulin-binding drug, methods for treating or preventing cancer or a neurotrophic disorder comprising administering to a subject in need thereof an effective amount of a Panaxytriol Compound and a tubulin-binding drug, and methods for making a Panaxytriol Compound.
    Type: Application
    Filed: February 22, 2008
    Publication date: May 26, 2011
    Inventors: Samuel J. Danishefsky, Heedong Yun, Ting-Chao Chou, Xiaoguang Lei, Dalibor Sames
  • Patent number: 7935689
    Abstract: Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed, compound of the formula (I): wherein n is 1 or 2; m is 0, 1, 2, 3, 4, 5, 6, 7 or 8; q is 0 or 1; t is 0 or 1; R1 is alkyl having from 1 to 3 carbon atoms; R2 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms; R3 and R4 together are alkyl having two or three carbon atoms; or R3 and R4 are the same as each other and each is methyl or ethyl; R5 is hydrogen or alkyl having from one to six carbon atoms.
    Type: Grant
    Filed: May 11, 2007
    Date of Patent: May 3, 2011
    Assignee: Wellstat Therapeutics Corporation
    Inventors: Shalini Sharma, Reid W. von Borstel
  • Publication number: 20110039819
    Abstract: The present invention relates to substituted phenoxybenzamide compounds of general formula (I): in which R1, R2, R3, R4, R5, X, R6 and q are as defined in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: April 9, 2009
    Publication date: February 17, 2011
    Inventors: Marion Hitchcock, Ingo Hartung
  • Patent number: 7838693
    Abstract: The present invention provides novel methods for preparing a key intermediate, 3,5-di-O-acyl-2-fluoro-2-C-methyl-D-ribono-?-lactone (2), for the preparation of 1-(2-deoxy-2-fluoro-2-C-methyl-?-D-ribofuranosyl)cytosine (1), which is a potent and selective anti-hepatitis C virus agent.
    Type: Grant
    Filed: December 11, 2007
    Date of Patent: November 23, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Miall Cedilote, Thomas Cleary, Hans Iding, Pingsheng Zhang
  • Publication number: 20100292491
    Abstract: The reaction of alcohols with oxocarboxylates to form acetals or ketals is catalyzed by unexpectedly low levels of protic acids. By employing low acid catalyst levels compared to amounts conventionally used, rapid formation of acetal or ketal is facilitated while the formation of oxocarboxylate esters is minimized. Further employing a significant molar excess of oxocarboxylate in conjunction with low acid catalyst level gives rise to the rapid and clean formation of acetals and ketals from oxocarboxylates and alcohols.
    Type: Application
    Filed: April 9, 2010
    Publication date: November 18, 2010
    Applicant: SEGETIS, INC.
    Inventors: Sergey Selifonov, Scott D. Rothstein, Brian D. Mullen
  • Publication number: 20100292373
    Abstract: The present disclosure relates to methods of preparation of compounds resulting from the reaction of levulinic esters and epoxidized unsaturated fatty acid esters. The compounds are useful as renewable biomass-based plasticizers for a variety of polymers. Mono-, di- and tri-ketal adducts formed in a reaction between alkyl esters of levulinate and epoxidized unsaturated fatty acid esters derived from vegetable oils are also disclosed.
    Type: Application
    Filed: November 22, 2006
    Publication date: November 18, 2010
    Inventor: Sergey Selifonov
  • Patent number: 7825126
    Abstract: Disclosed are (N)-methanocarba adenine nucleosides of the formula: as highly potent A3 adenosine receptor agonists, pharmaceutical compositions comprising such nucleosides, and a method of use of these nucleosides, wherein R1-R6 are as defined in the specification. These nucleosides are contemplated for use in the treatment a number of diseases, for example, inflammation, cardiac ischemia, stroke, asthma, diabetes, and cardiac arrhythmias. The invention also provides compounds that are agonists of both A1 and A3 adenosine receptors for use in cardioprotection.
    Type: Grant
    Filed: September 2, 2005
    Date of Patent: November 2, 2010
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Kenneth A. Jacobson, Bhalchandra V. Joshi, Susanna Tchilibon
  • Publication number: 20100273968
    Abstract: The invention pertains to a process for preparing compounds of formula (I-A) or (I-B) here below: by reaction of perfluoroallylfluorosulfate (FAFS) of formula (II): with at least one hypofluorite of formula (II-A) or (II-B): wherein: RF in formulae (I-A) and (II-A) is a monovalent fluorocarbon C1-C20 group, optionally comprising oxygen catenary atoms, optionally comprising functional groups comprising heteroatoms (e.g. —SO2F groups); R?F in formulae (I-B) and (II-B) is a divalent fluorocarbon C1-C6 group, preferably a group of formula wherein X1 and X2, equal to or different from each other, are independently a fluorine atom or a C1-C3 fluorocarbon group. The FAFS-hypofluorite adducts of formulae (I-A) and (I-B) can be produced with high selectivity so as to access useful intermediates which can further be reacted taking advantage of the un-modified fluorosulfate group chemistry.
    Type: Application
    Filed: December 17, 2008
    Publication date: October 28, 2010
    Applicant: SOLVAY SOLEXIS S.P.A.
    Inventors: Giuseppe Marchionni, Vito Tortelli