Additional Chalcogen Attached Indirectly To The Hetero Ring By Nonionic Bonding Patents (Class 549/501)
  • Patent number: 4337354
    Abstract: The invention relates to novel [(5,6,9a-substituted-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]alkanoi c and cycloalkanoic acid and their analogs, esters, salts and derivatives. These compounds are synthesized by methods selected from a number of synthetic routes depending on the particular structure, choice of intermediate or preferred reaction sequence. The compounds are useful in the treatment and prevention of injury to the brain and spinal chord due to accidents, ischemic stroke and hydrocephalus; compositions for such uses are also disclosed.
    Type: Grant
    Filed: February 19, 1981
    Date of Patent: June 29, 1982
    Assignee: Merck & Co., Inc.
    Inventors: Edward J. Cragoe, Jr., Gerald E. Stokker, Norman P. Gould
  • Patent number: 4332815
    Abstract: Perhaloalkylvinylcyclopropanecarboxylates having the general formula ##STR1## are disclosed wherein one of Y and Z is a perhaloalkyl group. Compounds in which R is hydroxy, halogen or lower alkoxy are novel intermediates for preparation of insecticidal esters in which R is --OR.sup.1 where R.sup.1 is a wide variety of alcohol residues. The insecticidal efficacy and preparation of the compounds and intermediates therefor are described and exemplified.
    Type: Grant
    Filed: July 1, 1980
    Date of Patent: June 1, 1982
    Assignee: FMC Corporation
    Inventor: John F. Engel
  • Patent number: 4331610
    Abstract: The present invention relates to a process for the preparation of carbonic acid esters of mono- or polyalcohols, which is characterized in that urethanes are reacted with monoalcohols or with polyalcohols in a molar ratio of alcohol to urethane group of at least 1 to 1, in the presence of a catalyst, at reaction temperatures of between 120.degree. C. and 270.degree. C.The present invention thus also relates to a process for the preparation of oligocarbonates and of polycarbonates, which is characterized in that monourethanes or bisurethanes are reacted with primary dialcohols in a molar ratio of about 1.5:1 to about 1:1.5, together with monoalcohols, in the presence of catalysts, at reaction temperatures of between 120.degree. C. and 270.degree. C.
    Type: Grant
    Filed: January 17, 1980
    Date of Patent: May 25, 1982
    Assignee: Bayer Aktiengesellschaft
    Inventors: Walter Heitz, Peter Ball
  • Patent number: 4328168
    Abstract: This invention provides a convenient and commercially adaptable process for the preparation of vinylcyclopropane derivatives in high yield. For the process an alkylating agent and activated methylene compound are reacted in the presence of a cyclic polyether compound and alkali metal compound. Water can also be present and/or the reaction may be carried out in an inert organic diluent.
    Type: Grant
    Filed: October 27, 1980
    Date of Patent: May 4, 1982
    Assignee: Emery Industries, Inc.
    Inventor: Richard G. Fayter, Jr.