Chalcogen Attached Indirectly To The Hetero Ring By Nonionic Bonding Patents (Class 549/497)
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Patent number: 11767424Abstract: The present invention provides a polyfunctional phenolic resin and a polyfunctional epoxy resin having low viscosity and having excellent mechanical properties and heat resistance of a cured product to be obtained, a curable resin composition containing these, and a cured product thereof. Specifically, provided are a polyfunctional phenolic resin formed with a naphthol structure optionally having a substituent on an aromatic ring and a catechol structure optionally having a methyl group as a substituent on an aromatic ring bonded together via a methylene group optionally having a substituent, a polyfunctional epoxy resin obtained by epoxidizing the polyfunctional phenolic resin, a curable resin composition containing any of these, and a cured product thereof.Type: GrantFiled: October 1, 2020Date of Patent: September 26, 2023Assignee: DIC CorporationInventors: Shinji Onda, Kunihiro Morinaga
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Patent number: 11459287Abstract: Arene-immobilized Ru(II)TsDPEN Noyori-Ikariya catalysts anchored to silica through the coordinated ?6-arene are provided. The catalysts efficiently catalyze many reactions, including the asymmetric transfer hydrogenation of ketones to alcohols.Type: GrantFiled: October 6, 2021Date of Patent: October 4, 2022Assignee: KING ABDULAZIZ UNIVERSITYInventors: Hind Faisal Alshaikh, Julian Knight
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Patent number: 11028105Abstract: Disclosed herein are borazine, borate, and azaborinine compounds and compositions, methods of making said compounds and compositions, and methods of forming aromatic difluorocarbon compounds and difluorocarbon compounds.Type: GrantFiled: June 28, 2019Date of Patent: June 8, 2021Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Nathaniel Szymczak, Jacob Geri
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Patent number: 10519172Abstract: Disclosed herein are borazine complexes and use of the same in perfluoroalkylation reactions.Type: GrantFiled: June 23, 2017Date of Patent: December 31, 2019Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Nathaniel Szymczak, Jacob Geri
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Patent number: 10428038Abstract: The present invention provides a single step process for the synthesis of furfuryl ethyl ether comprises refluxing the reaction mixture of furfuryl alcohol, ethanol and catalyst at temperature in the range of 80 to 120° C. for the period in the range of 3 to 7 hrs to afford furfuryl ethyl ether. The catalyst used in present invention is Zr incorporated SBA-15. Further, the conversion of furfuryl alcohol is in the range of 60 to 90%. The selectivity of reaction towards furfuryl ethyl ether is in the range of 85 to 95%.Type: GrantFiled: January 18, 2019Date of Patent: October 1, 2019Assignee: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCHInventors: Chandrashekhar Vasant Rode, Chetana Rupak Patil
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Patent number: 9334253Abstract: A direct trifluoromethylation method preferably using a trifluoromethane as a fluoro-methylating species. In particular, the present method is used for preparing a trifluoromethylated substrate by reacting a fluoromethylatable substrate with a trifiuoromethylating agent in the presence of an alkoxide or metal salt of silazane under conditions sufficient to trifluoromethylate the substrate; wherein the fluoromethylatable substrate includes chlorosilanes, carbonyl compounds such as esters, aryl halides, aldehydes, ketones, chalcones, alkyl formates, alkyl halides, aryl halides, alkyl borates, carbon dioxide or sulfur.Type: GrantFiled: April 19, 2012Date of Patent: May 10, 2016Assignee: University of Southern CaliforniaInventors: G. K. Surya Prakash, Parag V. Jog, Patrice. T. D Batamack, George Olah
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Patent number: 9303050Abstract: Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided.Type: GrantFiled: February 17, 2015Date of Patent: April 5, 2016Assignee: Eisai R&D Management Co., Ltd.Inventors: Farid Benayoud, Trevor Lee Calkins, Charles E. Chase, William Christ
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Patent number: 9023874Abstract: The invention relates to alkylsulfide derivatives compounds of formula I as hereunder depicted or the enantiomers or veterinarily acceptable salts thereof which are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to methods for controlling invertebrate pests by using these compounds and to plant propagation material and to agricultural and veterinary compositions comprising said compounds. wherein U, R1, R2, R3U, X, n and p are defined as in the description.Type: GrantFiled: November 11, 2010Date of Patent: May 5, 2015Assignee: Merial, Inc.Inventors: Sebastian Soergel, Ralph Paulini, Steffen Gross, Carsten Beyer, Matthias Pohlman, Henricus Maria Martinus Bastiaans, Michael Rack, Deborah L. Culbertson, Douglas D. Anspaugh, Sarah Thompson, Vincent Salgado
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Patent number: 8999197Abstract: The invention provides a liquid crystal compound that has an excellent compatibility with other liquid crystal compounds and also has at least one of characteristics such as a high stability to heat, light or the like, a suitable refractive index anisotropy (?n), a low threshold voltage and a suitable dielectric anisotropy (??). A compound represented by formula (1) For example, R1 is alkyl having 1 to 10 carbons, R2 is halogen or alkenyl having 2 to 10 carbons; the ring A1, the ring A2 and the ring A3 are 1,4-cyclohexylene or 1,4-phenylene; Z1, Z2 and Z3 are a single bond or alkylene having 1 to 4 carbons; G is —CH2— or —O—; and m is 1, and n and p is 0 or 1.Type: GrantFiled: October 24, 2013Date of Patent: April 7, 2015Assignees: JNC Corporation, JNC Petrochemical CorporationInventors: Tokifumi Masukawa, Yasuyuki Goto, Tomohiro Yano
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Publication number: 20150057457Abstract: The ?,?-unsaturated ketone moiety of a substrate representative of non-food based biomass was hydrogenated to the corresponding saturated alcohol moiety using a composition including (1) a copper salt; (2) a phosphine; (3) a polar aprotic solvent such as acetonitrile, and (4) a compound suitable for providing hydrogen for the hydrogenation, such as a suitable silane material or a suitable siloxane material.Type: ApplicationFiled: March 13, 2013Publication date: February 26, 2015Applicant: Los Alamos National Security, LLCInventors: John C. Gordon, Christopher R. Waidmann
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Publication number: 20150044509Abstract: Compounds of the formula (I), (Ia) or (Ib) wherein A1, and A? is for example (II) is 1 or 2; X is C1-C4 alkylene or CO; Y is for example O, O(CO), O(CO)O, R1 is for example hydrogen, d-dsalkyl, C3-C30cycloalkyl, phenyl, naphthyl, anthracyl, phenanthryl, biphenylyl, fluorenyl or C3-C20heteroaryl, all of which optionally are substituted; R2 and R3 for example are C1-C10haloalkylene which is optionally substituted, or R2 and R3 are phenylene, which optionally is substituted; R4 is a group (A) or a group (B); R5 and R6 for example are C1-C20alkyl; or R4 and R5 or R4 and R6 together form a straight-chain C2-C6alkylene, R5 and R6 together form a straight-chain C2-C6alkylene; R7, R8, R9 and R10 ifor example are C1-C20alkyl; M for example is C1-C20alkylene, C2-C20alkenylene, C2-C20alkynylene; R25 and R26 are for example hydrogen, C1-C20alkyl; R27, R28, R29, R30 and R31 are for example hydrogen, C1-C20alkyl, C2-C20alkenyl, C3-C20cycloalkyl, or two radicals R27 and R28, R28 and R29, R29 and R30 and/or R30 and R31 togetType: ApplicationFiled: April 17, 2013Publication date: February 12, 2015Applicant: BASF SEInventors: Kazuhiko Kunimoto, Hisatoshi Kura
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Patent number: 8884035Abstract: Disclosed herein are processes comprising contacting isosorbide with hydrogen in the presence of a first hydrogenation catalyst to form a first product mixture comprising tetrahydrofuran-2,5-dimethanol. The processes can further comprise heating the first product mixture in the presence of hydrogen and a second hydrogenation catalyst to form a second product mixture comprising 1,6-hexanediol. The first and second hydrogenation catalysts can be the same or different.Type: GrantFiled: December 28, 2012Date of Patent: November 11, 2014Assignee: E I du Pont de Nemours and CompanyInventors: Wathudura Indika Namal de Silva, Ekaterini Korovessi, Carl Andrew Menning, Joseph E Murphy, Joachim C Ritter, Sourav Kumar Sengupta, Christina S Stauffer
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Publication number: 20140243562Abstract: The present invention provides a process for preparing 1,2-pentanediol by reacting furfuryl alcohol with hydrogen in the presence of a catalyst system. The catalyst system contains platinum oxide or contains ruthenium supported on aluminum oxide or activated carbon. The invention also relates to the respective catalysts and processes for producing the catalyst system.Type: ApplicationFiled: November 25, 2013Publication date: August 28, 2014Applicant: Evonik Industries AGInventors: Marianne OMEIS, Manfred NEUMANN, Volker BREHME, Christoph THEIS, Dorit WOLF, Peter CLAUS, Martin LUCAS, Rene ECKERT
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Publication number: 20140135374Abstract: Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.Type: ApplicationFiled: June 13, 2012Publication date: May 15, 2014Applicant: BIKAM PHARMACEUTICALS, INC.Inventor: David S. Garvey
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Patent number: 8685274Abstract: The invention provides a liquid crystal compound that has an excellent compatibility with other liquid crystal compounds and also has at least one of characteristics such as a high stability to heat, light or the like, a suitable refractive index anisotropy (?n), a low threshold voltage and a suitable dielectric anisotropy (??). A compound represented by formula (1). For example, R1 is alkyl having 1 to 10 carbons, R2 is halogen or alkenyl having 2 to 10 carbons; the ring A1, the ring A2 and the ring A3 are 1,4-cyclohexylene or 1,4-phenylene; Z1, Z2 and Z3 are a single bond or alkylene having 1 to 4 carbons; G is —CH2— or —O—; and m is 1, and n and p is 0 or 1.Type: GrantFiled: June 10, 2011Date of Patent: April 1, 2014Assignees: JNC Corporation, JNC Petrochemical CorporationInventors: Tokifumi Masukawa, Yasuyuki Goto, Tomohiro Yano
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Publication number: 20140066640Abstract: A direct trifluoromethylation method preferably using a trifluoromethane as a fluoro-methylating species. In particular, the present method is used for preparing a trifluoromethylated substrate by reacting a fluoromethylatable substrate with a trifiuoromethylating agent in the presence of an alkoxide or metal salt of silazane under conditions sufficient to trifluoromethylate the substrate; wherein the fluoromethylatable substrate includes chlorosilanes, carbonyl compounds such as esters, aryl halides, aldehydes, ketones, chalcones, alkyl formates, alkyl halides, aryl halides, alkyl borates, carbon dioxide or sulfur.Type: ApplicationFiled: April 19, 2012Publication date: March 6, 2014Applicant: UNIVERSITY OF SOUTHERN CALIFORNIAInventors: G.K. Surya Prakash, Parag V. Jog, Patrice T.D. Batamack, George A. Olah
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Publication number: 20140054499Abstract: The invention provides a liquid crystal compound that has an excellent compatibility with other liquid crystal compounds and also has at least one of characteristics such as a high stability to heat, light or the like, a suitable refractive index anisotropy (?n), a low threshold voltage and a suitable dielectric anisotropy (??). A compound represented by formula (1). For example, R1 is alkyl having 1 to 10 carbons, R2 is halogen or alkenyl having 2 to 10 carbons; the ring A1, the ring A2 and the ring A3 are 1,4-cyclohexylene or 1,4-phenylene; Z1, Z2 and Z3 are a single bond or alkylene having 1 to 4 carbons; G is —CH2— or —O—; and m is 1, and n and p is 0 or 1.Type: ApplicationFiled: October 24, 2013Publication date: February 27, 2014Applicants: JNC PETROCHEMICAL CORPORATION, JNC CORPORATIONInventors: Tokifumi MASUKAWA, Yasuyuki GOTO, Tomohiro YANO
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Patent number: 8648332Abstract: Alkoxy-substituted phenyltetraene nonlinear optically active compounds, films and devices that include the compounds, and methods for making and using the compounds, films, and devices.Type: GrantFiled: May 28, 2009Date of Patent: February 11, 2014Assignee: University of WashingtonInventors: Kwan-Yue Jen, Jingdong Luo, Su Huang, Yen-Ju Cheng, Tae-Dong Kim, Zhengwei Shi, Xinghua Zhou, Brent M. Polishak, Yanqing Tian
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Publication number: 20140031562Abstract: A method of performing a chemical reaction includes reacting an allyl donor and a substrate in a reaction mixture, and forming a homoallylic alcohol in the reaction mixture. The substrate may be an aldehyde or a hemiacetal. The reaction mixture includes a ruthenium catalyst, carbon monoxide at a level of at least 1 equivalent relative to the substrate, and water at a level of at least 1 equivalent relative to the substrate, and an amine at a level of from 0 to 0.5 equivalent relative to the substrate. The reaction mixture may also include a halide, and the equivalents of the amine may be similar to those of the halide. The reacting includes maintaining the reaction mixture at a temperature of at least 40° C. The method may be catalytic in metal, environmentally benign, amenable to large-scale applications, and applicable to a wide range of substrates.Type: ApplicationFiled: August 28, 2009Publication date: January 30, 2014Applicant: The Board of Trustees of the University of IllinoiInventors: Scott E. Denmark, Selena Milicevic, Son T. Nguyen
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Publication number: 20140005301Abstract: The present invention relates to a heat-curable composition comprising (a) at least one compound which is capable of undergoing cationic polymerization; and (b) at least one sulfonium sulfate selected from compounds of the formulae Ia and Ib where Yn? is a monovalent or divalent anion selected from (1) where n, M, R1 to R10 are as defined in claim 1 and in the description. The present invention also relates to novel sulfonium sulfates of the formulae Ia and Ib, to a process for curing cationically polymerizable material and to the cured material obtained by said process.Type: ApplicationFiled: February 22, 2012Publication date: January 2, 2014Applicant: BASF SEInventors: Kazuhiko Kunimoto, Hisatoshi Kura
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Publication number: 20130317223Abstract: A method of performing a chemical reaction includes reacting a compound selected from the group consisting of an organohalide and an organo-pseudohalide, and a protected organoboronic acid represented by formula (I) in a reaction mixture: R1—B-T??(I); where R1 represents an organic group, T represents a conformationally rigid protecting group, and B represents boron having sp3 hybridization. When unprotected, the corresponding organoboronic acid is unstable by the boronic acid neat stability test. The reaction mixture further includes a base having a pKB of at least 1 and a palladium catalyst. The method further includes forming a cross-coupled product in the reaction mixture.Type: ApplicationFiled: November 6, 2012Publication date: November 28, 2013Applicant: The Board of Trustees of the University of IllinoisInventors: Martin D. Burke, David M. Knapp, Eric P. Gillis
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Publication number: 20130281664Abstract: The present invention relates to novel Ruthenium catalysts and related borohydride complexes, and the use of such catalysts, inter alia, for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including the preparation of polyamides (e.g., polypeptides) by reacting dialcohols and diamines and/or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (i.e.Type: ApplicationFiled: October 11, 2011Publication date: October 24, 2013Inventors: David Milstein, Ekambaram Balaraman, Chidambaram Gunanathan, Boopathy Gnanaprakasam, Jing Zhang
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Patent number: 8513162Abstract: There is provided a halogen-containing organosulfur compound having a controlling effect on arthropod pests represented by the formula (I): wherein m represents 0, 1 or 2; n represents 0, 1 or 2; A represents an optionally substituted 3- to 8-membered saturated heterocyclic group; Q represents a fluorine atom or a C1-C5 haloalkyl group having at least one fluorine atom; R1, R1a and R3 independently represent an optionally halogenated C1-C4 chain hydrocarbon group, etc.; R2, R2a and R4 independently represent an optionally halogenated C1-C4 chain hydrocarbon group, etc.Type: GrantFiled: December 24, 2009Date of Patent: August 20, 2013Assignee: Sumitomo Chemical Company, LimitedInventor: Hiromasa Mitsudera
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Publication number: 20130158276Abstract: Provided is a catalyst for asymmetric reduction, which can be produced by a convenient and safe production method, has a strong catalytic activity, and has excellent stereoselectivity. The present invention relates to a ruthenium complex represented by the following formula (1): wherein R1 represents an alkyl group or the like; Y represents a hydrogen atom; X represents a halogen atom or the like; j and k each represent 0 or 1; R2 and R3 each represent an alkyl group or the like; R11 to R19 each represent a hydrogen atom, an alkyl group or the like; Z represents oxygen or sulfur; n1 represents 1 or 2; and n2 represents an integer from 1 to 3, a method for producing the ruthenium complex, a catalyst for asymmetric reduction formed from the ruthenium complex, and methods for selectively producing an optically active alcohol and an optically active amine using the catalyst for asymmetric reduction.Type: ApplicationFiled: June 17, 2011Publication date: June 20, 2013Applicant: TAKASAGO INTERNATIONAL CORPORATIONInventors: Taichiro Touge, Hideki Nara, Tomohiko Hakamada
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Publication number: 20130130102Abstract: An ether compound represented by the following formula and its use: wherein n represents 0 or 1, m represents an integer of 0 to 2, Y represents —O—, —S—, —C(?O)—O—, and —O—C(?O)—, X1 and X2 represent a hydrogen atom or a fluorine atom, and R represents an aliphatic hydrocarbon group having 1 to 20 carbon atoms and substituted with one or more fluorine atoms, with a proviso that, when m is 0, R has 3 to 20 carbon atoms. R may have in the bond thereof intervening oxygen atom, sulfur atom, and carbonyl group.Type: ApplicationFiled: July 22, 2011Publication date: May 23, 2013Applicant: ZEON CORPORATIONInventors: Kei Sakamoto, Natsuko Nakata, Kumi Okuyama
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Patent number: 8338626Abstract: Method for the manufacture of 5-alkoxymethylfurfural derivatives by reacting a fructose and/or glucose-containing starting material with an alcohol in the presence of a catalytic or sub-stoechiometric amount of heterogeneous acid catalyst. The catalysts may be employed in a continuous flow fixed bed or catalytic distillation reactor. The ethers can be applied as a fuel or fuel additive.Type: GrantFiled: December 8, 2011Date of Patent: December 25, 2012Assignee: Furanix Technologies B.V.Inventors: Gerardus Johannes Maria Gruter, Frits Dautzenberg
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Patent number: 8324409Abstract: The present disclosure provides methods to make liquid fuels from renewable, carbon neutral precursors. Specifically, methods to prepare 2,5-dimethylfuran from a source of fructose or other carbohydrates using a one-pot synthesis are provided. In some embodiments, the disclosed methods avoid the isolation of intermediates, and employ “green” reagents like formic acid and acetic acid.Type: GrantFiled: April 22, 2011Date of Patent: December 4, 2012Assignee: The Board of Trustees of the University of IllinoisInventors: Thomas B. Rauchfuss, Todsapon Thananatthanachon
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Patent number: 8277521Abstract: Accordingly, the current invention provides a method for the manufacture of a mixture of a furfural and a 5-(alkoxymethyl)furfural derivative by reacting a C5 and C6 sugar-containing starting material with an alcohol in the presence of an acid catalyst, followed by the hydrogenation and/or etherification of the mixture of furfural and 5-(alkoxymethyl)furfural to convert the aldehyde function of both 5-(alkoxymethyl)furfural and furfural into an alkoxymethyl function or methyl function.Type: GrantFiled: September 5, 2008Date of Patent: October 2, 2012Assignee: Furanix Technologies B.V.Inventor: Gerardus Johannes Maria Gruier
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Patent number: 8231693Abstract: The present invention concerns a method for the manufacture of a 5-substituted 2-(alkoxymethyl)furan (or a mixture of such furans) by reacting a starting material comprising at least a 5-substituted furfural with hydrogen in the presence of an alcohol and a catalyst system.Type: GrantFiled: September 5, 2008Date of Patent: July 31, 2012Assignee: Furanix Technologies B.V.Inventor: Gerardus Johannes Maria Gruter
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Publication number: 20120157373Abstract: Antimicrobial compounds, such as silanol or alcohol, include a protecting or leaving group that can protect the compound from degradation during the process of preparing a medical device containing the compound or reduce the volatility of the compound relative to its counterpart without the leaving group. Nearly any hydrolysable leaving group may be employed. The leaving group may be an agent that may serve a therapeutic function in addition to protecting or retaining the antimicrobial agents.Type: ApplicationFiled: February 29, 2012Publication date: June 21, 2012Applicant: MEDTRONIC, INC.Inventors: Paul Hsien-Fu Wu, Catherine E. Taylor, Linnus Cheruiyot, Jianwei Li, Terese A. Bartlett, Matt Bergan
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Publication number: 20120142934Abstract: A method for synthesis of secondary alcohols is provided for pharmaceutical secondary alcohol by addition of organoboronic acids with aldehydes in presence of the cobalt ion and bidentate ligands as the catalyst. In addition, an enantioselective synthesis method for secondary alcohols is also herein provided in the present invention. The present invention has advantages in using less expensive cobalt ion and commercially available chiral ligands as the catalyst, wide scope of organoboronic acids and aldehydes compatible with this catalytic reaction and achieving excellent yields and/or enantiomeric excess.Type: ApplicationFiled: March 10, 2011Publication date: June 7, 2012Inventors: Chien-Hong CHENG, Jaganathan Karthikeyan, Pang-Chi Huang
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Patent number: 8153667Abstract: The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith.Type: GrantFiled: September 14, 2007Date of Patent: April 10, 2012Assignee: Cephalon, Inc.Inventors: Edward R. Bacon, Sankar Chatterjee, Derek Dunn, Rabindranath Tripathy
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Publication number: 20110309300Abstract: The invention provides a liquid crystal compound that has an excellent compatibility with other liquid crystal compounds and also has at least one of characteristics such as a high stability to heat, light or the like, a suitable refractive index anisotropy (?n), a low threshold voltage and a suitable dielectric anisotropy (??). A compound represented by formula (1). For example, R1 is alkyl having 1 to 10 carbons, R2 is halogen or alkenyl having 2 to 10 carbons; the ring A1, the ring A2 and the ring A3 are 1,4-cyclohexylene or 1,4-phenylene; Z1, Z2 and Z3 are a single bond or alkylene having 1 to 4 carbons; G is —CH2— or —O—; and m is 1, and n and p is 0 or 1.Type: ApplicationFiled: June 10, 2011Publication date: December 22, 2011Applicants: CHISSO PETROCHEMICAL CORPORATION, JNC CORPORATIONInventors: Tokifumi MASUKAWA, Yasuyuki GOTO, Tomohiro YANO
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Publication number: 20110201819Abstract: Disclosed is a practical method for efficiently producing an alcohol compound by hydrogenating an aldehyde by using a homogeneous copper catalyst which is an easily-available low-cost metal species. Specifically disclosed is a method for producing an alcohol compound, which is characterized in that a hydrogenation reaction of an aldehyde compound is performed in the presence of a homogeneous copper catalyst and a diphosphine compound.Type: ApplicationFiled: December 11, 2008Publication date: August 18, 2011Applicant: TAKASAGO INTERNATIONAL CORPORATIONInventor: Hideo Shimizu
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Publication number: 20110178102Abstract: Compounds are disclosed which inhibit SIR2 base exchange more than deacetylation, thus enhancing SIR2 deacetylation activity. Methods of using the compounds for enhancing SIR2 deacetylation activity and increasing longevity of an organism are also disclosed. Methods for screening for compounds that enhance SIR2 deacetylation activity and increase longevity of an organism are additionally disclosed.Type: ApplicationFiled: June 30, 2004Publication date: July 21, 2011Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITYInventors: Vern L Schramm, Anthony A. Suave
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Publication number: 20110065929Abstract: Provide that a useful catalyst for homogeneous hydrogenation, particularly a catalyst for homogeneous asymmetric hydrogenation for hydrogenation, particularly asymmetric hydrogenation, which is obtainable with comparative ease and is excellent in economically and workability, and a process for producing a hydrogenated compound of an unsaturated compound, particularly an optically active compound using said catalyst with a high yield and optical purity.Type: ApplicationFiled: November 18, 2010Publication date: March 17, 2011Applicant: TAKASAGO INTERNATIONAL CORPORATIONInventors: Hideo SHIMIZU, Daisuke IGARASHI, Wataru KURIYAMA, Yukinori YUSA
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Publication number: 20100280235Abstract: Disclosed is a method for mass-producing 4?-ethynyl d4T (4?-ethynyl-2?,3?-didehydro-3?-deoxythymidine) by a simpler process at low cost. Specifically disclosed is a method for producing 4?-ethynyl d4T, which is characterized by comprising a step for introducing a triple bond-containing group into a furfuryl alcohol derivative or a levoglucosenone, by reacting the furfuryl alcohol derivative or levoglucosenone with a certain compound, and a step for reacting a compound represented by the formula (III), which is obtained by the aforementioned step, with thymine.Type: ApplicationFiled: December 26, 2008Publication date: November 4, 2010Applicant: Oncolys Biopharma, IncInventors: Katsuyuki Nagai, Shinya Kiguchi, Hiroya Koyama, William Ewan Hume, Satoshi Tsujimoto
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Patent number: 7790900Abstract: An optically active nitro compound having two hydrogen atoms on its ?-carbon atom and having ?-asymmetric carbon atom can be produced by making ?,?-unsaturated nitroolefin having a hydrogen atom on its ?-carbon atom react with at least two organosilicon compounds having at least one silicon-hydrogen bond in the molecule in the presence of an asymmetric copper complex, or react with an organosilicon compound having at least one silicon-hydrogen bond in the molecule in the presence of an asymmetric copper complex and water.Type: GrantFiled: May 17, 2004Date of Patent: September 7, 2010Assignees: Sumitomo Chemical Company, LimitedInventor: Erick M. Carreira
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Publication number: 20100218416Abstract: The current invention provides a method for the manufacture of an ether of 5-hydroxymethylfurfural by reacting a hexose-containing starting material with a branched C3-C20 monoalcohol in the presence of a catalytic or sub-stoichiometric amount of an acid catalyst.Type: ApplicationFiled: September 5, 2008Publication date: September 2, 2010Applicant: FURANIX TECHNOLOGIES B.V.Inventor: Gerardus Johannes Maria Gruter
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Publication number: 20100212217Abstract: The current invention provides a method for the manufacture of an ether of 5-hydroxymethylfurfural through hydroxy-alkoxy-addition by reacting 5-hydroxymethylfurfural with an olefin in the presence of an acid catalystType: ApplicationFiled: September 5, 2008Publication date: August 26, 2010Applicant: Furanix Technologies B.V.Inventor: Gerardus Johannes Maria Gruter
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Patent number: 7767623Abstract: A fungicidal compound of formula (1): where Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, the ring being substituted by groups R7, R8 and R9; R1 is hydrogen, optionally substituted (C1-4)alkylC(?O), optionally substituted (C1-4)alkylC(?O)O, optionally substituted (C1-4)alkoxy(C1-4)alkyl, optionally substituted allyl, optionally substituted propargyl or optionally substituted allenyl; R2, R3, R4and R5 are each, independently, hydrogen, halogen, optionally substituted (C1-4)alkoxy(C1-4)alkoxy or optionally substituted (C1-4)alkoxy(C1-4)alkyl; R6 is an organic group containing three to thirteen carbon atoms and at least one silicon atom and, optionally, one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, and is optionally substituted by one to four independently selected halogen atoms; R7, R8 and R9are each, independently, hydrogen, halogen, C1-3alkyl, C1-3haloalkyl, C1-3alkoxy(CType: GrantFiled: March 21, 2003Date of Patent: August 3, 2010Assignee: Syngenta Crop Protection, Inc.Inventors: Josef Ehrenfreund, Pierre Joseph Marcel Jung, Hans Tobler, Harald Walter
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Publication number: 20100168440Abstract: Provide that a useful catalyst for homogeneous hydrogenation, particularly a catalyst for homogeneous asymmetric hydrogenation for hydrogenation, particularly asymmetric hydrogenation, which is obtainable with comparative ease and is excellent in economically and workability, and a process for producing a hydrogenated compound of an unsaturated compound, particularly an optically active compound using said catalyst with a high yield and optical purity.Type: ApplicationFiled: February 9, 2010Publication date: July 1, 2010Applicant: Takasago International CorporationInventors: Hideo SHIMIZU, Daisuke Igarashi, Wataru Kuriyama, Yukinori Yusa
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Publication number: 20100137262Abstract: The disclosure provides compounds, compositions and methods using these compounds and compositions to stimulate the differentiation of cells and inhibit excessive cell proliferation of certain cells, including cancer cells and skin cells, which may be useful in the treatment of diseases characterized by abnormal cell proliferation and/or cell differentiation such as leukemia, myelofibrosis and psoriasis without the well known effect on calcium metabolism, which gives rise to hypercalcemia.Type: ApplicationFiled: April 18, 2008Publication date: June 3, 2010Inventors: Gary H. Posner, Kimberly S. Petersen, Lindsey C. Hess, Douglas T. Genna, Scott Borella
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Publication number: 20100121062Abstract: A method of performing a chemical reaction includes reacting a compound selected from the group consisting of an organohalide and an organo-pseudohalide, and a protected organoboronic acid represented by formula (I) in a reaction mixture: R1—B-T ??(I); where R1 represents an organic group, T represents a conformationally rigid protecting group, and B represents boron having sp3 hybridization. When unprotected, the corresponding organoboronic acid is unstable by the boronic acid neat stability test. The reaction mixture further includes a base having a pKB of at least 1 and a palladium catalyst. The method further includes forming a cross-coupled product in the reaction mixture.Type: ApplicationFiled: September 25, 2009Publication date: May 13, 2010Applicant: The Board of Trustees of the University of IllinoisInventors: Martin D. Burke, David M. Knapp, Eric P. Gillis
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Publication number: 20100081833Abstract: Accordingly, the current invention provides a method for the manufacture of an ether or ester of 5-hydroxymethyl-furfural by reacting a hexose-containing starting material or HMF with an alcohol or an organic acid dissolved into an ionic liquid, using a metal chloride as catalyst.Type: ApplicationFiled: September 5, 2008Publication date: April 1, 2010Applicant: FURANIX TECHNOLOGIES B.V.Inventors: Gerardus Johannes Maria Gruter, Leo Ernest Manzer, Ano Sofia Vagueiro De Sousa Dias, Frits Dautzenberg, Jindra Purmova
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Patent number: 7678299Abstract: The present invention provides stock solutions for production of nonlinear-optical materials using a wet coating method. In particular, the invention provides a stock solution containing a nonlinear-optically active organic compound, which is a push-pull ?-conjugated compound having a particular chemical structure, having one or more cross-linkable functional groups. In addition, the invention provides a stock solution comprising a nonlinear-optically active organic compound having at least a certain chemical structure and a matrix-forming compound having one or more cross-linkable functional groups. Further, the invention provides a nonlinear-optical material and a nonlinear-optical device, both prepared by using the stock solutions.Type: GrantFiled: June 15, 2004Date of Patent: March 16, 2010Assignee: Fuji Xerox Co., Ltd.Inventors: Yasuhiro Yamaguchi, Tomozumi Uesaka, Hokuto Takada, Yasunari Nishikata
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Publication number: 20100063294Abstract: Provided is an alcohol production method comprising the step of reducing an ester or a lactone with hydrogen to produce a corresponding alcohol without addition of a base compound by using, as a catalyst, a ruthenium complex represented by the following general formula (1): RuH(X)(L1)(L2)n ??(1) wherein X represents a monovalent anionic ligand, L1 represents a tetradentate ligand having at least one coordinating phosphino group and at least one coordinating amino group or a bidentate aminophosphine ligand having one coordinating phosphino group and one coordinating amino group, and L2 represents a bidentate aminophosphine ligand having one coordinating phosphino group and one coordinating amino group, provided that n is 0 when L1 is the tetradentate ligand, and n is 1 when L1 is the bidentate aminophosphine ligand.Type: ApplicationFiled: September 3, 2009Publication date: March 11, 2010Applicant: TAKASAGO INTERNATIONAL CORPORATIONInventors: Wataru KURIYAMA, Yasunori Ino, Osamu Ogata
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Patent number: 7638256Abstract: Silicon compounds having fluorinated hemiacetal structure are provided. Silicone resins having the same structure have an appropriate acidity to enable formation of a finer pattern by minimizing the pattern collapse by swelling, exhibit improved resistance to the etching used in the pattern transfer to an organic film, and are thus suited for use in resist compositions for the bilayer process.Type: GrantFiled: July 6, 2006Date of Patent: December 29, 2009Assignee: Shin-Etsu Chemical Co., Ltd.Inventors: Takeshi Kinsho, Takeru Watanabe, Mutsuo Nakashima, Yoshitaka Hamada
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Publication number: 20090306414Abstract: The present invention provides a microchannel reactor that is used as a new reaction device capable of greatly expanding the utilization range of chemical reactions occurring in microspaces. A solution of a soluble linear polymer containing ligands and a solution of a soluble transition metal molecule are individually introduced into a microreactor, the flows are merged inside a microchannel and a metal polymer membrane of a complex formed is generated at the interface of the flows. The membrane is used as a solid catalyst, and various reactions such as carbon-carbon bond formation reactions, oxidation reactions and the like can be conducted at extremely fast reaction rates.Type: ApplicationFiled: February 27, 2007Publication date: December 10, 2009Inventors: Yasuhiro Uozumi, Yoichi Yamada, Naoshi Fukuyama, Tomohiko Beppu, Takehiko Kitamori, Masaharu Ueno
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Publication number: 20090205535Abstract: A method for modifying ethylenic unsaturation in a triglyceride. One or more unsaturated fatty acyl moieties present in the triglyceride are substituted with a a lactone substitution, a dihydrofuran substitution, or a ketone substitution via an electron acceptor mediated reaction. The resulting reaction products are useful, for example, as lubricants, metalworking fluids, mold release agents, hydraulic fluids, or dielectric fluids, or as components of lubricants, metalworking fluids, mold release agents, hydraulic fluids, or dielectric fluids, and modified fatty acids for polymer synthesis.Type: ApplicationFiled: February 16, 2009Publication date: August 20, 2009Applicant: BUNGE OILS, INC.Inventors: Neil Wallace Higgins, Jerry F. Stults