Chalcogen Attached Indirectly To The Hetero Ring By Nonionic Bonding Patents (Class 549/497)
  • Patent number: 10519172
    Abstract: Disclosed herein are borazine complexes and use of the same in perfluoroalkylation reactions.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: December 31, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Nathaniel Szymczak, Jacob Geri
  • Patent number: 10428038
    Abstract: The present invention provides a single step process for the synthesis of furfuryl ethyl ether comprises refluxing the reaction mixture of furfuryl alcohol, ethanol and catalyst at temperature in the range of 80 to 120° C. for the period in the range of 3 to 7 hrs to afford furfuryl ethyl ether. The catalyst used in present invention is Zr incorporated SBA-15. Further, the conversion of furfuryl alcohol is in the range of 60 to 90%. The selectivity of reaction towards furfuryl ethyl ether is in the range of 85 to 95%.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: October 1, 2019
    Assignee: COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
    Inventors: Chandrashekhar Vasant Rode, Chetana Rupak Patil
  • Patent number: 9334253
    Abstract: A direct trifluoromethylation method preferably using a trifluoromethane as a fluoro-methylating species. In particular, the present method is used for preparing a trifluoromethylated substrate by reacting a fluoromethylatable substrate with a trifiuoromethylating agent in the presence of an alkoxide or metal salt of silazane under conditions sufficient to trifluoromethylate the substrate; wherein the fluoromethylatable substrate includes chlorosilanes, carbonyl compounds such as esters, aryl halides, aldehydes, ketones, chalcones, alkyl formates, alkyl halides, aryl halides, alkyl borates, carbon dioxide or sulfur.
    Type: Grant
    Filed: April 19, 2012
    Date of Patent: May 10, 2016
    Assignee: University of Southern California
    Inventors: G. K. Surya Prakash, Parag V. Jog, Patrice. T. D Batamack, George Olah
  • Patent number: 9303050
    Abstract: Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided.
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: April 5, 2016
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Farid Benayoud, Trevor Lee Calkins, Charles E. Chase, William Christ
  • Patent number: 9023874
    Abstract: The invention relates to alkylsulfide derivatives compounds of formula I as hereunder depicted or the enantiomers or veterinarily acceptable salts thereof which are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to methods for controlling invertebrate pests by using these compounds and to plant propagation material and to agricultural and veterinary compositions comprising said compounds. wherein U, R1, R2, R3U, X, n and p are defined as in the description.
    Type: Grant
    Filed: November 11, 2010
    Date of Patent: May 5, 2015
    Assignee: Merial, Inc.
    Inventors: Sebastian Soergel, Ralph Paulini, Steffen Gross, Carsten Beyer, Matthias Pohlman, Henricus Maria Martinus Bastiaans, Michael Rack, Deborah L. Culbertson, Douglas D. Anspaugh, Sarah Thompson, Vincent Salgado
  • Patent number: 8999197
    Abstract: The invention provides a liquid crystal compound that has an excellent compatibility with other liquid crystal compounds and also has at least one of characteristics such as a high stability to heat, light or the like, a suitable refractive index anisotropy (?n), a low threshold voltage and a suitable dielectric anisotropy (??). A compound represented by formula (1) For example, R1 is alkyl having 1 to 10 carbons, R2 is halogen or alkenyl having 2 to 10 carbons; the ring A1, the ring A2 and the ring A3 are 1,4-cyclohexylene or 1,4-phenylene; Z1, Z2 and Z3 are a single bond or alkylene having 1 to 4 carbons; G is —CH2— or —O—; and m is 1, and n and p is 0 or 1.
    Type: Grant
    Filed: October 24, 2013
    Date of Patent: April 7, 2015
    Assignees: JNC Corporation, JNC Petrochemical Corporation
    Inventors: Tokifumi Masukawa, Yasuyuki Goto, Tomohiro Yano
  • Publication number: 20150057457
    Abstract: The ?,?-unsaturated ketone moiety of a substrate representative of non-food based biomass was hydrogenated to the corresponding saturated alcohol moiety using a composition including (1) a copper salt; (2) a phosphine; (3) a polar aprotic solvent such as acetonitrile, and (4) a compound suitable for providing hydrogen for the hydrogenation, such as a suitable silane material or a suitable siloxane material.
    Type: Application
    Filed: March 13, 2013
    Publication date: February 26, 2015
    Applicant: Los Alamos National Security, LLC
    Inventors: John C. Gordon, Christopher R. Waidmann
  • Publication number: 20150044509
    Abstract: Compounds of the formula (I), (Ia) or (Ib) wherein A1, and A? is for example (II) is 1 or 2; X is C1-C4 alkylene or CO; Y is for example O, O(CO), O(CO)O, R1 is for example hydrogen, d-dsalkyl, C3-C30cycloalkyl, phenyl, naphthyl, anthracyl, phenanthryl, biphenylyl, fluorenyl or C3-C20heteroaryl, all of which optionally are substituted; R2 and R3 for example are C1-C10haloalkylene which is optionally substituted, or R2 and R3 are phenylene, which optionally is substituted; R4 is a group (A) or a group (B); R5 and R6 for example are C1-C20alkyl; or R4 and R5 or R4 and R6 together form a straight-chain C2-C6alkylene, R5 and R6 together form a straight-chain C2-C6alkylene; R7, R8, R9 and R10 ifor example are C1-C20alkyl; M for example is C1-C20alkylene, C2-C20alkenylene, C2-C20alkynylene; R25 and R26 are for example hydrogen, C1-C20alkyl; R27, R28, R29, R30 and R31 are for example hydrogen, C1-C20alkyl, C2-C20alkenyl, C3-C20cycloalkyl, or two radicals R27 and R28, R28 and R29, R29 and R30 and/or R30 and R31 toget
    Type: Application
    Filed: April 17, 2013
    Publication date: February 12, 2015
    Applicant: BASF SE
    Inventors: Kazuhiko Kunimoto, Hisatoshi Kura
  • Patent number: 8884035
    Abstract: Disclosed herein are processes comprising contacting isosorbide with hydrogen in the presence of a first hydrogenation catalyst to form a first product mixture comprising tetrahydrofuran-2,5-dimethanol. The processes can further comprise heating the first product mixture in the presence of hydrogen and a second hydrogenation catalyst to form a second product mixture comprising 1,6-hexanediol. The first and second hydrogenation catalysts can be the same or different.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: November 11, 2014
    Assignee: E I du Pont de Nemours and Company
    Inventors: Wathudura Indika Namal de Silva, Ekaterini Korovessi, Carl Andrew Menning, Joseph E Murphy, Joachim C Ritter, Sourav Kumar Sengupta, Christina S Stauffer
  • Publication number: 20140243562
    Abstract: The present invention provides a process for preparing 1,2-pentanediol by reacting furfuryl alcohol with hydrogen in the presence of a catalyst system. The catalyst system contains platinum oxide or contains ruthenium supported on aluminum oxide or activated carbon. The invention also relates to the respective catalysts and processes for producing the catalyst system.
    Type: Application
    Filed: November 25, 2013
    Publication date: August 28, 2014
    Applicant: Evonik Industries AG
    Inventors: Marianne OMEIS, Manfred NEUMANN, Volker BREHME, Christoph THEIS, Dorit WOLF, Peter CLAUS, Martin LUCAS, Rene ECKERT
  • Publication number: 20140135374
    Abstract: Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.
    Type: Application
    Filed: June 13, 2012
    Publication date: May 15, 2014
    Applicant: BIKAM PHARMACEUTICALS, INC.
    Inventor: David S. Garvey
  • Patent number: 8685274
    Abstract: The invention provides a liquid crystal compound that has an excellent compatibility with other liquid crystal compounds and also has at least one of characteristics such as a high stability to heat, light or the like, a suitable refractive index anisotropy (?n), a low threshold voltage and a suitable dielectric anisotropy (??). A compound represented by formula (1). For example, R1 is alkyl having 1 to 10 carbons, R2 is halogen or alkenyl having 2 to 10 carbons; the ring A1, the ring A2 and the ring A3 are 1,4-cyclohexylene or 1,4-phenylene; Z1, Z2 and Z3 are a single bond or alkylene having 1 to 4 carbons; G is —CH2— or —O—; and m is 1, and n and p is 0 or 1.
    Type: Grant
    Filed: June 10, 2011
    Date of Patent: April 1, 2014
    Assignees: JNC Corporation, JNC Petrochemical Corporation
    Inventors: Tokifumi Masukawa, Yasuyuki Goto, Tomohiro Yano
  • Publication number: 20140066640
    Abstract: A direct trifluoromethylation method preferably using a trifluoromethane as a fluoro-methylating species. In particular, the present method is used for preparing a trifluoromethylated substrate by reacting a fluoromethylatable substrate with a trifiuoromethylating agent in the presence of an alkoxide or metal salt of silazane under conditions sufficient to trifluoromethylate the substrate; wherein the fluoromethylatable substrate includes chlorosilanes, carbonyl compounds such as esters, aryl halides, aldehydes, ketones, chalcones, alkyl formates, alkyl halides, aryl halides, alkyl borates, carbon dioxide or sulfur.
    Type: Application
    Filed: April 19, 2012
    Publication date: March 6, 2014
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: G.K. Surya Prakash, Parag V. Jog, Patrice T.D. Batamack, George A. Olah
  • Publication number: 20140054499
    Abstract: The invention provides a liquid crystal compound that has an excellent compatibility with other liquid crystal compounds and also has at least one of characteristics such as a high stability to heat, light or the like, a suitable refractive index anisotropy (?n), a low threshold voltage and a suitable dielectric anisotropy (??). A compound represented by formula (1). For example, R1 is alkyl having 1 to 10 carbons, R2 is halogen or alkenyl having 2 to 10 carbons; the ring A1, the ring A2 and the ring A3 are 1,4-cyclohexylene or 1,4-phenylene; Z1, Z2 and Z3 are a single bond or alkylene having 1 to 4 carbons; G is —CH2— or —O—; and m is 1, and n and p is 0 or 1.
    Type: Application
    Filed: October 24, 2013
    Publication date: February 27, 2014
    Applicants: JNC PETROCHEMICAL CORPORATION, JNC CORPORATION
    Inventors: Tokifumi MASUKAWA, Yasuyuki GOTO, Tomohiro YANO
  • Patent number: 8648332
    Abstract: Alkoxy-substituted phenyltetraene nonlinear optically active compounds, films and devices that include the compounds, and methods for making and using the compounds, films, and devices.
    Type: Grant
    Filed: May 28, 2009
    Date of Patent: February 11, 2014
    Assignee: University of Washington
    Inventors: Kwan-Yue Jen, Jingdong Luo, Su Huang, Yen-Ju Cheng, Tae-Dong Kim, Zhengwei Shi, Xinghua Zhou, Brent M. Polishak, Yanqing Tian
  • Publication number: 20140031562
    Abstract: A method of performing a chemical reaction includes reacting an allyl donor and a substrate in a reaction mixture, and forming a homoallylic alcohol in the reaction mixture. The substrate may be an aldehyde or a hemiacetal. The reaction mixture includes a ruthenium catalyst, carbon monoxide at a level of at least 1 equivalent relative to the substrate, and water at a level of at least 1 equivalent relative to the substrate, and an amine at a level of from 0 to 0.5 equivalent relative to the substrate. The reaction mixture may also include a halide, and the equivalents of the amine may be similar to those of the halide. The reacting includes maintaining the reaction mixture at a temperature of at least 40° C. The method may be catalytic in metal, environmentally benign, amenable to large-scale applications, and applicable to a wide range of substrates.
    Type: Application
    Filed: August 28, 2009
    Publication date: January 30, 2014
    Applicant: The Board of Trustees of the University of Illinoi
    Inventors: Scott E. Denmark, Selena Milicevic, Son T. Nguyen
  • Publication number: 20140005301
    Abstract: The present invention relates to a heat-curable composition comprising (a) at least one compound which is capable of undergoing cationic polymerization; and (b) at least one sulfonium sulfate selected from compounds of the formulae Ia and Ib where Yn? is a monovalent or divalent anion selected from (1) where n, M, R1 to R10 are as defined in claim 1 and in the description. The present invention also relates to novel sulfonium sulfates of the formulae Ia and Ib, to a process for curing cationically polymerizable material and to the cured material obtained by said process.
    Type: Application
    Filed: February 22, 2012
    Publication date: January 2, 2014
    Applicant: BASF SE
    Inventors: Kazuhiko Kunimoto, Hisatoshi Kura
  • Publication number: 20130317223
    Abstract: A method of performing a chemical reaction includes reacting a compound selected from the group consisting of an organohalide and an organo-pseudohalide, and a protected organoboronic acid represented by formula (I) in a reaction mixture: R1—B-T??(I); where R1 represents an organic group, T represents a conformationally rigid protecting group, and B represents boron having sp3 hybridization. When unprotected, the corresponding organoboronic acid is unstable by the boronic acid neat stability test. The reaction mixture further includes a base having a pKB of at least 1 and a palladium catalyst. The method further includes forming a cross-coupled product in the reaction mixture.
    Type: Application
    Filed: November 6, 2012
    Publication date: November 28, 2013
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Martin D. Burke, David M. Knapp, Eric P. Gillis
  • Publication number: 20130281664
    Abstract: The present invention relates to novel Ruthenium catalysts and related borohydride complexes, and the use of such catalysts, inter alia, for (1) hydrogenation of amides (including polyamides) to alcohols and amines; (2) preparing amides from alcohols with amines (including the preparation of polyamides (e.g., polypeptides) by reacting dialcohols and diamines and/or by polymerization of amino alcohols); (3) hydrogenation of esters to alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones) or polyesters); (4) hydrogenation of organic carbonates (including polycarbonates) to alcohols and hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (5) dehydrogenative coupling of alcohols to esters; (6) hydrogenation of secondary alcohols to ketones; (7) amidation of esters (i.e.
    Type: Application
    Filed: October 11, 2011
    Publication date: October 24, 2013
    Inventors: David Milstein, Ekambaram Balaraman, Chidambaram Gunanathan, Boopathy Gnanaprakasam, Jing Zhang
  • Patent number: 8513162
    Abstract: There is provided a halogen-containing organosulfur compound having a controlling effect on arthropod pests represented by the formula (I): wherein m represents 0, 1 or 2; n represents 0, 1 or 2; A represents an optionally substituted 3- to 8-membered saturated heterocyclic group; Q represents a fluorine atom or a C1-C5 haloalkyl group having at least one fluorine atom; R1, R1a and R3 independently represent an optionally halogenated C1-C4 chain hydrocarbon group, etc.; R2, R2a and R4 independently represent an optionally halogenated C1-C4 chain hydrocarbon group, etc.
    Type: Grant
    Filed: December 24, 2009
    Date of Patent: August 20, 2013
    Assignee: Sumitomo Chemical Company, Limited
    Inventor: Hiromasa Mitsudera
  • Publication number: 20130158276
    Abstract: Provided is a catalyst for asymmetric reduction, which can be produced by a convenient and safe production method, has a strong catalytic activity, and has excellent stereoselectivity. The present invention relates to a ruthenium complex represented by the following formula (1): wherein R1 represents an alkyl group or the like; Y represents a hydrogen atom; X represents a halogen atom or the like; j and k each represent 0 or 1; R2 and R3 each represent an alkyl group or the like; R11 to R19 each represent a hydrogen atom, an alkyl group or the like; Z represents oxygen or sulfur; n1 represents 1 or 2; and n2 represents an integer from 1 to 3, a method for producing the ruthenium complex, a catalyst for asymmetric reduction formed from the ruthenium complex, and methods for selectively producing an optically active alcohol and an optically active amine using the catalyst for asymmetric reduction.
    Type: Application
    Filed: June 17, 2011
    Publication date: June 20, 2013
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Taichiro Touge, Hideki Nara, Tomohiko Hakamada
  • Publication number: 20130130102
    Abstract: An ether compound represented by the following formula and its use: wherein n represents 0 or 1, m represents an integer of 0 to 2, Y represents —O—, —S—, —C(?O)—O—, and —O—C(?O)—, X1 and X2 represent a hydrogen atom or a fluorine atom, and R represents an aliphatic hydrocarbon group having 1 to 20 carbon atoms and substituted with one or more fluorine atoms, with a proviso that, when m is 0, R has 3 to 20 carbon atoms. R may have in the bond thereof intervening oxygen atom, sulfur atom, and carbonyl group.
    Type: Application
    Filed: July 22, 2011
    Publication date: May 23, 2013
    Applicant: ZEON CORPORATION
    Inventors: Kei Sakamoto, Natsuko Nakata, Kumi Okuyama
  • Patent number: 8338626
    Abstract: Method for the manufacture of 5-alkoxymethylfurfural derivatives by reacting a fructose and/or glucose-containing starting material with an alcohol in the presence of a catalytic or sub-stoechiometric amount of heterogeneous acid catalyst. The catalysts may be employed in a continuous flow fixed bed or catalytic distillation reactor. The ethers can be applied as a fuel or fuel additive.
    Type: Grant
    Filed: December 8, 2011
    Date of Patent: December 25, 2012
    Assignee: Furanix Technologies B.V.
    Inventors: Gerardus Johannes Maria Gruter, Frits Dautzenberg
  • Patent number: 8324409
    Abstract: The present disclosure provides methods to make liquid fuels from renewable, carbon neutral precursors. Specifically, methods to prepare 2,5-dimethylfuran from a source of fructose or other carbohydrates using a one-pot synthesis are provided. In some embodiments, the disclosed methods avoid the isolation of intermediates, and employ “green” reagents like formic acid and acetic acid.
    Type: Grant
    Filed: April 22, 2011
    Date of Patent: December 4, 2012
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Thomas B. Rauchfuss, Todsapon Thananatthanachon
  • Patent number: 8277521
    Abstract: Accordingly, the current invention provides a method for the manufacture of a mixture of a furfural and a 5-(alkoxymethyl)furfural derivative by reacting a C5 and C6 sugar-containing starting material with an alcohol in the presence of an acid catalyst, followed by the hydrogenation and/or etherification of the mixture of furfural and 5-(alkoxymethyl)furfural to convert the aldehyde function of both 5-(alkoxymethyl)furfural and furfural into an alkoxymethyl function or methyl function.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: October 2, 2012
    Assignee: Furanix Technologies B.V.
    Inventor: Gerardus Johannes Maria Gruier
  • Patent number: 8231693
    Abstract: The present invention concerns a method for the manufacture of a 5-substituted 2-(alkoxymethyl)furan (or a mixture of such furans) by reacting a starting material comprising at least a 5-substituted furfural with hydrogen in the presence of an alcohol and a catalyst system.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: July 31, 2012
    Assignee: Furanix Technologies B.V.
    Inventor: Gerardus Johannes Maria Gruter
  • Publication number: 20120157373
    Abstract: Antimicrobial compounds, such as silanol or alcohol, include a protecting or leaving group that can protect the compound from degradation during the process of preparing a medical device containing the compound or reduce the volatility of the compound relative to its counterpart without the leaving group. Nearly any hydrolysable leaving group may be employed. The leaving group may be an agent that may serve a therapeutic function in addition to protecting or retaining the antimicrobial agents.
    Type: Application
    Filed: February 29, 2012
    Publication date: June 21, 2012
    Applicant: MEDTRONIC, INC.
    Inventors: Paul Hsien-Fu Wu, Catherine E. Taylor, Linnus Cheruiyot, Jianwei Li, Terese A. Bartlett, Matt Bergan
  • Publication number: 20120142934
    Abstract: A method for synthesis of secondary alcohols is provided for pharmaceutical secondary alcohol by addition of organoboronic acids with aldehydes in presence of the cobalt ion and bidentate ligands as the catalyst. In addition, an enantioselective synthesis method for secondary alcohols is also herein provided in the present invention. The present invention has advantages in using less expensive cobalt ion and commercially available chiral ligands as the catalyst, wide scope of organoboronic acids and aldehydes compatible with this catalytic reaction and achieving excellent yields and/or enantiomeric excess.
    Type: Application
    Filed: March 10, 2011
    Publication date: June 7, 2012
    Inventors: Chien-Hong CHENG, Jaganathan Karthikeyan, Pang-Chi Huang
  • Patent number: 8153667
    Abstract: The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases therewith.
    Type: Grant
    Filed: September 14, 2007
    Date of Patent: April 10, 2012
    Assignee: Cephalon, Inc.
    Inventors: Edward R. Bacon, Sankar Chatterjee, Derek Dunn, Rabindranath Tripathy
  • Publication number: 20110309300
    Abstract: The invention provides a liquid crystal compound that has an excellent compatibility with other liquid crystal compounds and also has at least one of characteristics such as a high stability to heat, light or the like, a suitable refractive index anisotropy (?n), a low threshold voltage and a suitable dielectric anisotropy (??). A compound represented by formula (1). For example, R1 is alkyl having 1 to 10 carbons, R2 is halogen or alkenyl having 2 to 10 carbons; the ring A1, the ring A2 and the ring A3 are 1,4-cyclohexylene or 1,4-phenylene; Z1, Z2 and Z3 are a single bond or alkylene having 1 to 4 carbons; G is —CH2— or —O—; and m is 1, and n and p is 0 or 1.
    Type: Application
    Filed: June 10, 2011
    Publication date: December 22, 2011
    Applicants: CHISSO PETROCHEMICAL CORPORATION, JNC CORPORATION
    Inventors: Tokifumi MASUKAWA, Yasuyuki GOTO, Tomohiro YANO
  • Publication number: 20110201819
    Abstract: Disclosed is a practical method for efficiently producing an alcohol compound by hydrogenating an aldehyde by using a homogeneous copper catalyst which is an easily-available low-cost metal species. Specifically disclosed is a method for producing an alcohol compound, which is characterized in that a hydrogenation reaction of an aldehyde compound is performed in the presence of a homogeneous copper catalyst and a diphosphine compound.
    Type: Application
    Filed: December 11, 2008
    Publication date: August 18, 2011
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventor: Hideo Shimizu
  • Publication number: 20110178102
    Abstract: Compounds are disclosed which inhibit SIR2 base exchange more than deacetylation, thus enhancing SIR2 deacetylation activity. Methods of using the compounds for enhancing SIR2 deacetylation activity and increasing longevity of an organism are also disclosed. Methods for screening for compounds that enhance SIR2 deacetylation activity and increase longevity of an organism are additionally disclosed.
    Type: Application
    Filed: June 30, 2004
    Publication date: July 21, 2011
    Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
    Inventors: Vern L Schramm, Anthony A. Suave
  • Publication number: 20110065929
    Abstract: Provide that a useful catalyst for homogeneous hydrogenation, particularly a catalyst for homogeneous asymmetric hydrogenation for hydrogenation, particularly asymmetric hydrogenation, which is obtainable with comparative ease and is excellent in economically and workability, and a process for producing a hydrogenated compound of an unsaturated compound, particularly an optically active compound using said catalyst with a high yield and optical purity.
    Type: Application
    Filed: November 18, 2010
    Publication date: March 17, 2011
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Hideo SHIMIZU, Daisuke IGARASHI, Wataru KURIYAMA, Yukinori YUSA
  • Publication number: 20100280235
    Abstract: Disclosed is a method for mass-producing 4?-ethynyl d4T (4?-ethynyl-2?,3?-didehydro-3?-deoxythymidine) by a simpler process at low cost. Specifically disclosed is a method for producing 4?-ethynyl d4T, which is characterized by comprising a step for introducing a triple bond-containing group into a furfuryl alcohol derivative or a levoglucosenone, by reacting the furfuryl alcohol derivative or levoglucosenone with a certain compound, and a step for reacting a compound represented by the formula (III), which is obtained by the aforementioned step, with thymine.
    Type: Application
    Filed: December 26, 2008
    Publication date: November 4, 2010
    Applicant: Oncolys Biopharma, Inc
    Inventors: Katsuyuki Nagai, Shinya Kiguchi, Hiroya Koyama, William Ewan Hume, Satoshi Tsujimoto
  • Patent number: 7790900
    Abstract: An optically active nitro compound having two hydrogen atoms on its ?-carbon atom and having ?-asymmetric carbon atom can be produced by making ?,?-unsaturated nitroolefin having a hydrogen atom on its ?-carbon atom react with at least two organosilicon compounds having at least one silicon-hydrogen bond in the molecule in the presence of an asymmetric copper complex, or react with an organosilicon compound having at least one silicon-hydrogen bond in the molecule in the presence of an asymmetric copper complex and water.
    Type: Grant
    Filed: May 17, 2004
    Date of Patent: September 7, 2010
    Assignees: Sumitomo Chemical Company, Limited
    Inventor: Erick M. Carreira
  • Publication number: 20100218416
    Abstract: The current invention provides a method for the manufacture of an ether of 5-hydroxymethylfurfural by reacting a hexose-containing starting material with a branched C3-C20 monoalcohol in the presence of a catalytic or sub-stoichiometric amount of an acid catalyst.
    Type: Application
    Filed: September 5, 2008
    Publication date: September 2, 2010
    Applicant: FURANIX TECHNOLOGIES B.V.
    Inventor: Gerardus Johannes Maria Gruter
  • Publication number: 20100212217
    Abstract: The current invention provides a method for the manufacture of an ether of 5-hydroxymethylfurfural through hydroxy-alkoxy-addition by reacting 5-hydroxymethylfurfural with an olefin in the presence of an acid catalyst
    Type: Application
    Filed: September 5, 2008
    Publication date: August 26, 2010
    Applicant: Furanix Technologies B.V.
    Inventor: Gerardus Johannes Maria Gruter
  • Patent number: 7767623
    Abstract: A fungicidal compound of formula (1): where Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, the ring being substituted by groups R7, R8 and R9; R1 is hydrogen, optionally substituted (C1-4)alkylC(?O), optionally substituted (C1-4)alkylC(?O)O, optionally substituted (C1-4)alkoxy(C1-4)alkyl, optionally substituted allyl, optionally substituted propargyl or optionally substituted allenyl; R2, R3, R4and R5 are each, independently, hydrogen, halogen, optionally substituted (C1-4)alkoxy(C1-4)alkoxy or optionally substituted (C1-4)alkoxy(C1-4)alkyl; R6 is an organic group containing three to thirteen carbon atoms and at least one silicon atom and, optionally, one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, and is optionally substituted by one to four independently selected halogen atoms; R7, R8 and R9are each, independently, hydrogen, halogen, C1-3alkyl, C1-3haloalkyl, C1-3alkoxy(C
    Type: Grant
    Filed: March 21, 2003
    Date of Patent: August 3, 2010
    Assignee: Syngenta Crop Protection, Inc.
    Inventors: Josef Ehrenfreund, Pierre Joseph Marcel Jung, Hans Tobler, Harald Walter
  • Publication number: 20100168440
    Abstract: Provide that a useful catalyst for homogeneous hydrogenation, particularly a catalyst for homogeneous asymmetric hydrogenation for hydrogenation, particularly asymmetric hydrogenation, which is obtainable with comparative ease and is excellent in economically and workability, and a process for producing a hydrogenated compound of an unsaturated compound, particularly an optically active compound using said catalyst with a high yield and optical purity.
    Type: Application
    Filed: February 9, 2010
    Publication date: July 1, 2010
    Applicant: Takasago International Corporation
    Inventors: Hideo SHIMIZU, Daisuke Igarashi, Wataru Kuriyama, Yukinori Yusa
  • Publication number: 20100137262
    Abstract: The disclosure provides compounds, compositions and methods using these compounds and compositions to stimulate the differentiation of cells and inhibit excessive cell proliferation of certain cells, including cancer cells and skin cells, which may be useful in the treatment of diseases characterized by abnormal cell proliferation and/or cell differentiation such as leukemia, myelofibrosis and psoriasis without the well known effect on calcium metabolism, which gives rise to hypercalcemia.
    Type: Application
    Filed: April 18, 2008
    Publication date: June 3, 2010
    Inventors: Gary H. Posner, Kimberly S. Petersen, Lindsey C. Hess, Douglas T. Genna, Scott Borella
  • Publication number: 20100121062
    Abstract: A method of performing a chemical reaction includes reacting a compound selected from the group consisting of an organohalide and an organo-pseudohalide, and a protected organoboronic acid represented by formula (I) in a reaction mixture: R1—B-T ??(I); where R1 represents an organic group, T represents a conformationally rigid protecting group, and B represents boron having sp3 hybridization. When unprotected, the corresponding organoboronic acid is unstable by the boronic acid neat stability test. The reaction mixture further includes a base having a pKB of at least 1 and a palladium catalyst. The method further includes forming a cross-coupled product in the reaction mixture.
    Type: Application
    Filed: September 25, 2009
    Publication date: May 13, 2010
    Applicant: The Board of Trustees of the University of Illinois
    Inventors: Martin D. Burke, David M. Knapp, Eric P. Gillis
  • Publication number: 20100081833
    Abstract: Accordingly, the current invention provides a method for the manufacture of an ether or ester of 5-hydroxymethyl-furfural by reacting a hexose-containing starting material or HMF with an alcohol or an organic acid dissolved into an ionic liquid, using a metal chloride as catalyst.
    Type: Application
    Filed: September 5, 2008
    Publication date: April 1, 2010
    Applicant: FURANIX TECHNOLOGIES B.V.
    Inventors: Gerardus Johannes Maria Gruter, Leo Ernest Manzer, Ano Sofia Vagueiro De Sousa Dias, Frits Dautzenberg, Jindra Purmova
  • Patent number: 7678299
    Abstract: The present invention provides stock solutions for production of nonlinear-optical materials using a wet coating method. In particular, the invention provides a stock solution containing a nonlinear-optically active organic compound, which is a push-pull ?-conjugated compound having a particular chemical structure, having one or more cross-linkable functional groups. In addition, the invention provides a stock solution comprising a nonlinear-optically active organic compound having at least a certain chemical structure and a matrix-forming compound having one or more cross-linkable functional groups. Further, the invention provides a nonlinear-optical material and a nonlinear-optical device, both prepared by using the stock solutions.
    Type: Grant
    Filed: June 15, 2004
    Date of Patent: March 16, 2010
    Assignee: Fuji Xerox Co., Ltd.
    Inventors: Yasuhiro Yamaguchi, Tomozumi Uesaka, Hokuto Takada, Yasunari Nishikata
  • Publication number: 20100063294
    Abstract: Provided is an alcohol production method comprising the step of reducing an ester or a lactone with hydrogen to produce a corresponding alcohol without addition of a base compound by using, as a catalyst, a ruthenium complex represented by the following general formula (1): RuH(X)(L1)(L2)n ??(1) wherein X represents a monovalent anionic ligand, L1 represents a tetradentate ligand having at least one coordinating phosphino group and at least one coordinating amino group or a bidentate aminophosphine ligand having one coordinating phosphino group and one coordinating amino group, and L2 represents a bidentate aminophosphine ligand having one coordinating phosphino group and one coordinating amino group, provided that n is 0 when L1 is the tetradentate ligand, and n is 1 when L1 is the bidentate aminophosphine ligand.
    Type: Application
    Filed: September 3, 2009
    Publication date: March 11, 2010
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Wataru KURIYAMA, Yasunori Ino, Osamu Ogata
  • Patent number: 7638256
    Abstract: Silicon compounds having fluorinated hemiacetal structure are provided. Silicone resins having the same structure have an appropriate acidity to enable formation of a finer pattern by minimizing the pattern collapse by swelling, exhibit improved resistance to the etching used in the pattern transfer to an organic film, and are thus suited for use in resist compositions for the bilayer process.
    Type: Grant
    Filed: July 6, 2006
    Date of Patent: December 29, 2009
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Takeshi Kinsho, Takeru Watanabe, Mutsuo Nakashima, Yoshitaka Hamada
  • Publication number: 20090306414
    Abstract: The present invention provides a microchannel reactor that is used as a new reaction device capable of greatly expanding the utilization range of chemical reactions occurring in microspaces. A solution of a soluble linear polymer containing ligands and a solution of a soluble transition metal molecule are individually introduced into a microreactor, the flows are merged inside a microchannel and a metal polymer membrane of a complex formed is generated at the interface of the flows. The membrane is used as a solid catalyst, and various reactions such as carbon-carbon bond formation reactions, oxidation reactions and the like can be conducted at extremely fast reaction rates.
    Type: Application
    Filed: February 27, 2007
    Publication date: December 10, 2009
    Inventors: Yasuhiro Uozumi, Yoichi Yamada, Naoshi Fukuyama, Tomohiko Beppu, Takehiko Kitamori, Masaharu Ueno
  • Publication number: 20090205535
    Abstract: A method for modifying ethylenic unsaturation in a triglyceride. One or more unsaturated fatty acyl moieties present in the triglyceride are substituted with a a lactone substitution, a dihydrofuran substitution, or a ketone substitution via an electron acceptor mediated reaction. The resulting reaction products are useful, for example, as lubricants, metalworking fluids, mold release agents, hydraulic fluids, or dielectric fluids, or as components of lubricants, metalworking fluids, mold release agents, hydraulic fluids, or dielectric fluids, and modified fatty acids for polymer synthesis.
    Type: Application
    Filed: February 16, 2009
    Publication date: August 20, 2009
    Applicant: BUNGE OILS, INC.
    Inventors: Neil Wallace Higgins, Jerry F. Stults
  • Patent number: 7553970
    Abstract: The invention relates to a process for preparing enantiomer-enriched 3-heteroaryl-3-hydroxypropanoic acid derivatives and 3-heteroaryl-1-aminopropan-3-ols, and to their use.
    Type: Grant
    Filed: September 24, 2003
    Date of Patent: June 30, 2009
    Assignee: Lanxess Deutschland GmbH
    Inventors: Frank Berendes, Markus Eckert, Nils Brinkmann, Claus Dreisbach, Ruth Meissner, Rainhard Koch
  • Patent number: 7553867
    Abstract: The present invention provides a compound represented by the formula (I): [wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, p is 0, 1 or 2, and when p is 2, each R may be the same or different, R1 is a hydrogen atom or an optionally substituted hydrocarbon group, R2 is an optionally substituted aromatic group, Ring A is an optionally substituted monocyclic aromatic ring or optionally substituted bicyclic aromatic fused ring, X1 is an oxygen atom or a sulfur atom, X2 is a bond, an oxygen atom or —S(O)n— (wherein n is 0, 1 or 2), Y is a bond, an oxygen atom, —S(O)m—, —C(?O)—N(R3)— or —N(R3)—C(?O)— (R3 is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, and m is 0, 1 or 2), M1, M2 and M3 may be the same or different and are each independently a bond or an optionally substituted divalent aliphatic hydrocarbon group, and M4 is an optionally substituted divalent aliphatic hydrocarbon group] or a
    Type: Grant
    Filed: September 4, 2003
    Date of Patent: June 30, 2009
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Kazumasa Hamamura, Shigekazu Sasaki, Yuichiro Amano, Junichi Sakamoto, Kohji Fukatsu
  • Patent number: 7507840
    Abstract: Acceptor compounds useful for making hyperpolarizable organic chromophores having a ?-donor conjugated to a ?-acceptor through a ?-bridge.
    Type: Grant
    Filed: March 11, 2005
    Date of Patent: March 24, 2009
    Assignee: University of Washington
    Inventors: Larry R. Dalton, Kwan-Yue Jen, Timothy Londergan, William Brenden Carlson, Gregory Phelan, Diyun Huang, Daniel Casmier, Todd Ewy, Nicholas Buker