Cyclopentanohydrophenanthrene Ring System Containing Patents (Class 552/502)
With preservative or stabilizer (Class 552/503)
Heavy metal or aluminum containing (Class 552/504)
Boron, silicon, selenium or tellurium containing (Class 552/505)
Phosphorus attached directly or indirectly to the cyclopentanohydrophenanthrene ring system by nonionic bonding (Class 552/506)
Spiro (Class 552/508)
Plural cyclopentanohydrophenanthrene ring systems (Class 552/509)
The cyclopentanohydrophenanthrene ring system is part of a polycyclo ring system having at least five cyclos (Class 552/510)
Nitrogen bonded directly to the cyclopentanohydrophenanthrene ring system (Class 552/515)
Sulfur bonded directly to the cyclopentanohydrophenanthrene ring system (Class 552/523)
Carbon double bonded directly to the cyclopentanohydrophenantrene ring system (Class 552/526)
Halogen bonded directly at the 12-position of the cyclopentanohydrophenanthrene ring system (Class 552/535)
Halogen bonded directly at the 16-position of the cyclopentanohydrophenanthrene ring system (Class 552/536)
Halomethyl bonded directly to the cyclopentanohydrophenanthrene ring system (e.g., 16-trifluoromethyl progesterones, etc.) (Class 552/539)
Carbon bonded directly at the 17 beta-position of the cyclopentanohydrophenanthrene ring system is a member of an acyclic chain of six or more uninterrupted carbons (e.g., sterols, etc.) (Class 552/540)
Carbon bonded directly at the 17 beta-position of the cyclopentanohydrophenanthrene ring system is a member of an acyclic chain of five uninterrupted carbons (e.g., choladienes, cholanic acids, etc.) stocks, yeast, molds, etc.) (Class 552/548)
Carbon bonded directly at the 17 beta-position of the cyclopentanohydrophenanthrene ring system is a member of an acyclic chain of three or four uninterruped carbons, (e.g., diketobisnorcholenic acids, etc.) (Class 552/553)
Carbon bonded directly at the 17-beta-position of the cyclopentanohydrophenanthrene ring system is a member of an acyclic chain of two uninterrupted carbons (e.g., pregnanes, etc.) (Class 552/557)
Acyclic carbon bonded directly at the 17 beta-position of the cyclopentanohydrophenanthrene ring system (e.g., etiocholanic acids, 17 cyanoetiocholanes, 17-aldehydrostanes, etc.) (Class 552/610)
Three or more oxygens bonded directly to the cyclopentanohydrophenanthrene ring system (Class 552/612)
Two oxygens bonded directly to the cyclopentanohydrophenanthrene ring system (Class 552/623)
Oxygen bonded directly at the 16- or 17-position of the cyclopentanohydrophenanthrene ring system (Class 552/650)
  • Fluorine derivatives of vitamin D.sub.3 and process for producing the same
    Patent number: 5030626
    Abstract: There are disclosed herein novel derivatives of 26,26,26,27,27,27-hexafluorovitamin D.sub.3 providing excellent pharmacological effects, and a process for the preparation thereof. These novel compounds are represented by the general formula ##STR1## wherein R.sub.1 and R.sub.2 each denotes a hydrogen atom or a protecting group for the hydroxyl group; R.sub.3 and R.sub.4 each denotes a hydrogen atom, a hydroxyl group or a protected hydroxyl group and R.sub.4 ' and R.sub.5 ' each denotes a hydrogen atom, or alternatively R.sub.3 and R.sub.3 ' together or R.sub.4 and R.sub.4 ' together denote an oxo group; provided that R.sub.3, R.sub.3 ', R.sub.4 and R.sub.4 ' cannot denote hydrogen atoms simultaneously. The process for the preparation comprises subjecting a previtamin D.sub.3 derivative represented by the formula ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.3 ', R.sub.4 and R.sub.4 ' are as defined above, to thermal isomerization to give a vitamin D.sub.
    Type: Grant
    Filed: April 24, 1990
    Date of Patent: July 9, 1991
    Assignees: Sumitomo Pharmaceuticals Company, Limited, Taisho Pharmaceutical Co., Ltd.
    Inventors: Noritaka Hamma, Yoshikazu Saito, Toshio Nishizawa, Takashi Katsumata, Itsuro Sugata
  • Aromatic steroid 5-.alpha.-reductase inhibitors
    Patent number: 4954446
    Abstract: Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutial compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-.alpha.-reductase including using these compounds to reduce prostate size. Also invented are intermediates used in preparing these compounds.
    Type: Grant
    Filed: July 14, 1989
    Date of Patent: September 4, 1990
    Assignee: SmithKline Beecham Corporation
    Inventors: Dennis A. Holt, Mark A. Levy, Brian W. Metcalf
  • Novel 17-aryl-steroids
    Patent number: 4943566
    Abstract: A compound selected from the group consisting of compounds of the formula ##STR1## wherein R.sub.1 is an organo of 1 to 18 carbon atoms optionally containing at least one heteroatom connected to the C ring by a carbon atom, R.sub.2 is methyl or ethyl, the A and B rings being selected from the group consisting of ##STR2## Re is selected from the group consisting of hydrogen, optionally substituted alkyl of 1 to 6 carbon atoms and acyl and the D ring is selected from the group consisting of ##STR3## one of R.sub.3 and R.sub.4 is selected from the group consisting of hydroxy, protected hydroxy, acyl and alkoxy and the other is an optionally substituted aryl, R.sub.5 is an optionally substituted aryl and their non-toxic, pharmaceutically acceptable salts with acids and bases with the proviso that when the A and B rings are ##STR4## R.sub.1 is ##STR5## R.sub.2 is methyl, R.sub.3 is --OH, R.sub.4 is phenyl having anti proliferative properties.
    Type: Grant
    Filed: July 28, 1988
    Date of Patent: July 24, 1990
    Assignee: Roussel Uclafi
    Inventors: Lucien Nedelec, Francois Nique, Daniel Philibert, Martine Moguilewsky, Marie-Madeleine Bouton