Carbamic Acid Patents (Class 560/157)
  • Patent number: 9848599
    Abstract: The present invention relates to biocidal agents designed to protect industrial products against microbial, bacterial, fungal and algal infections. In particular, the present invention relates to co-crystals containing 3-iodopropynyl butylcarbamate (IPBC) and to compositions containing said co-crystals which possess improved physical, chemical and workability properties compared with the use of IPBC.
    Type: Grant
    Filed: April 9, 2013
    Date of Patent: December 26, 2017
    Assignee: POLITECNICO DI MILANO
    Inventors: Giuseppe Resnati, Pierangelo Metrangolo, Giancarlo Terraneo, Michele Baldrighi
  • Patent number: 9284260
    Abstract: A method for producing a racemate of a compound represented by Formula (1), including bringing a transition metal catalyst into contact with an optically active form of the compound represented by Formula (1): [in Formula (1), a ring X1 represents an aromatic ring; R1 represents a C1-6 alkyl group, a C3-8 cycloalkyl group, or a C1-6 halo-alkyl group; R2 is a group different from R1 and represents a C1-6 alkyl group, a C3-8 cycloalkyl group, or a C1-6 halo-alkyl group, or R2 and the ring X1 are bonded to each other to form a ring; a hydrogen atom(s) of the ring X1 is optionally replaced with a C1-6 alkyl group, a C1-6 halo-alkyl group, a cyano group, a nitro group, a C1-6 alkoxy group, or a halogen atom; and * represents an asymmetric carbon atom].
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: March 15, 2016
    Assignee: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Tomoaki Takahashi, Taro Hirose
  • Patent number: 9284293
    Abstract: A method of producing a carbonate product including mixing a DMC and methanol mixture with an alcohol, reacting the DMC with the alcohol to form carbonate product, and removing a substantial portion of unreacted DMC and methanol. In one embodiment, the method may be repeated to reach a desired alcohol conversion by adding more DMC and methanol mixture.
    Type: Grant
    Filed: August 19, 2011
    Date of Patent: March 15, 2016
    Assignee: HUNTSMAN PETROCHEMICAL LLC
    Inventors: Haibo Zhao, Mark Posey
  • Publication number: 20150148524
    Abstract: A method for the synthesis of an amino acid analogue or a salt, solvate, derivative, isomer or tautomer thereof comprising the steps of: (i) subjecting an amino acid containing a metathesisable group to metathesis with a compound containing a complementary metathesisable group of formula (I) or (II): (Formulae (I), (II)) wherein R1 and R2 are independently selected from H and substituted or unsubstituted C1 to C4 alkyl; each R3 is either absent or independently selected from a heteroatom, a substituted or unsubstituted C1 to C20 alkyl, and a substituted or unsubstituted C1 to C20 alkyl group interrupted by one or more heteroatoms; and each X is independently selected from H and an effector molecule; in the presence of a reagent to catalyse the metathesis to form a dicarba bridge between the amino acid containing a metathesisable group and the compound containing a complementary metathesisable group; and (ii) reducing the dicarba bridge to form a saturated dicarba bridge, wherein the reagent used to catalyse s
    Type: Application
    Filed: July 8, 2013
    Publication date: May 28, 2015
    Inventors: Zhen Wang, Andrea Robinson, Nicolas Daniel Spiccia, William Roy Jackson
  • Patent number: 9029590
    Abstract: The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids comprising at least one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.
    Type: Grant
    Filed: October 17, 2011
    Date of Patent: May 12, 2015
    Assignee: SIRNA Therapeutics, Inc.
    Inventors: Steven L. Colletti, Matthew G. Stanton
  • Patent number: 8999323
    Abstract: The present invention relates to a polymerization-curable composition for the preparation of biodegradable, biocompatible, cross-linked polymers on the basis of polyvinyl alcohol comprising: 5 to 100% by weight of (a) vinyl ester monomer(s) of one of the general formulas (I) to (III): wherein X is oxygen, sulfur, nitrogen, or phosphorus; n is 1 to 1000, at least 20% of the n being ?2; the R1 are selected from hydrogen; straight, branched or cyclic, saturated or unsaturated, n-valent hydrocarbon groups having 1 to 30 carbon atoms, which optionally have heteroatoms and are optionally substituted with one or more substituents selected from —OH, —COON, —CN, —CHO, and ?O, and n-valent radicals of biodegradable, biocompatible oligomers and polymers; m is an integer from 1 to 5; the R2 are selected from hydrogen, —OH, ?O, and the options listed for R1; and the R3 are selected from hydrogen, —OH, and the options listed for R1; 0 to 50% by weight of ethylenically unsaturated co-monomers; 0 to 10% by weight of (a)
    Type: Grant
    Filed: November 21, 2008
    Date of Patent: April 7, 2015
    Assignee: Technische Universität Wien
    Inventors: Robert Liska, Jürgen Stampfl, Franz Varga, Heinrich Gruber, Stefan Baudis, Christian Heller, Monika Schuster, Helga Bergmeister, Günter Weigel, Claudia Dworak
  • Patent number: 8957241
    Abstract: A method for producing a carbonyl compound of the present invention comprises a step (X) of reacting a specific compound having a urea bond with a carbonic acid derivative having a carbonyl group (—C(?O)—) under heating at a temperature equal to or higher than the thermal dissociation temperature of the urea bond to obtain the carbonyl compound.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: February 17, 2015
    Assignee: Asahi Kasei Chemicals Corporation
    Inventors: Masaaki Shinohata, Nobuhisa Miyake
  • Patent number: 8957176
    Abstract: The invention provides innovative blocked polyisocyanates whose crosslinking is initiated thermally and photochemically. The polyisocyanates comprise at least one thermally reversibly blocked NCO group whose blocking agent contains at least one group which on exposure to actinic radiation reacts, with polymerization, with ethylenically unsaturated compounds. A process for preparing the polyisocyanates, and their use in binders, is also provided.
    Type: Grant
    Filed: September 2, 2005
    Date of Patent: February 17, 2015
    Assignee: ALLNEX IP S.à.r.L.
    Inventors: Thomas Fäcke, Jan Weikard, Wolfgang Fischer
  • Patent number: 8937197
    Abstract: The invention provides a method for producing organic carbonates via the reaction of alcohols and carbon monoxide with oxygen adsorbed on a metallic gold or gold alloy catalyst.
    Type: Grant
    Filed: July 16, 2012
    Date of Patent: January 20, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: Cynthia M. Friend, Robert J. Madix, Bingjun Xu
  • Patent number: 8927602
    Abstract: The invention is directed to a method of treating fibromyalgia syndrome in a subject, comprising administering a therapeutically effective amount of a carbamoyl compound, or pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 1, 2010
    Date of Patent: January 6, 2015
    Assignee: SK Biopharmaceuticals Co., Ltd.
    Inventors: Sung James Lee, Susan Marie Melnick
  • Publication number: 20140377706
    Abstract: An aqueous solution containing 0.1-20 wt % of a substituted choline or thiocholine hydroxide is a useful developer for photosensitive resist materials. A resist pattern is formed by applying a chemically amplified positive resist composition onto a substrate to form a resist film, exposing the resist film to high-energy radiation, and developing the exposed resist film in an ammonium hydroxide-containing aqueous solution.
    Type: Application
    Filed: May 27, 2014
    Publication date: December 25, 2014
    Applicant: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Jun Hatakeyama, Masaki Ohashi
  • Patent number: 8895609
    Abstract: The invention is directed to a method of treating attention-deficit/hyperactivity disorder (ADHD) in a subject, comprising administering a therapeutically effective amount of a carbamoyl compound, or pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: November 3, 2010
    Date of Patent: November 25, 2014
    Assignee: SK Biopharmaceuticals Co., Ltd.
    Inventors: Sung James Lee, Susan Marie Melnick
  • Publication number: 20140296364
    Abstract: The invention relates to a dental material which comprises a polymerizable bisphosphonic acid of Formula I: The invention also relates to the use of a polymerizable bisphosphonic acid of Formula I for the preparation of a dental material and in particular for the preparation of an adhesive, cement or composite.
    Type: Application
    Filed: December 6, 2012
    Publication date: October 2, 2014
    Inventors: Norbert Moszner, Yohann Catel, Jörg Angermann, Thorsten Bock, Volker Rheinberger
  • Publication number: 20140288190
    Abstract: Hydrogels that degrade under appropriate conditions of pH and temperature by virtue of crosslinking compounds that cleave through an elimination reaction are described. The hydrogels may be used for delivery of various agents, such as pharmaceuticals. This invention provides hydrogels that degrade to smaller, soluble components in a non-enzymatic process upon exposure to physiological conditions and to methods to prepare them. The hydrogels are prepared from crosslinking agents that undergo elimination reactions under physiological conditions, thus cleaving the crosslinking agent from the backbone of the hydrogel. The invention also relates to the crosslinking agents themselves and intermediates in forming the hydro gels of the invention. The biodegradable hydro gels prepared according to the methods of the invention may be of use in diverse fields, including biomedical engineering, absorbent materials, and as carriers for drug delivery.
    Type: Application
    Filed: September 7, 2012
    Publication date: September 25, 2014
    Applicant: ProLynx LLC
    Inventors: Gary W. Ashley, Daniel V. Santi, Jeffrey C. Henise
  • Patent number: 8828098
    Abstract: Non-fluorinated blocked polyurethanes are described as extenders and, particularly as textile auxiliaries, for use with fluorochemical polymers in treating substrates, for example fibrous substrates, such as textile fabrics or yarns. The polyurethane is prepared by reacting a polyisocyanate, a blocking agent, and a non-fluorinated isocyanate reactive compound having an average alkyl chain length of 24 to 50 carbon atoms.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: September 9, 2014
    Assignee: 3M Innovative Properties Company
    Inventors: Stewart H. Corn, Chetan P. Jariwala
  • Patent number: 8816036
    Abstract: Catalysts, which are free of tin, are described which are useful in the reaction between an isocyanate and an alcohol, which is a key step for preparing polyurethane polymers. The catalyst is a metal complex or salt of formula (1): [Zn(L1)l1(L2)l2(Y)x]??(1) in which: l1?1 and l2=0 or 1; with l1+l2=2, x=1 or 2, the symbol L1 represents a ligand which is a ?-dicarbonylato anion or the enolate anion of a ?-dicarbonyl compound or an acetylacetato anion derived from a ?-ketoester, when l1=2, the symbols L1 are identical or different, the symbol L2 represents an anionic ligand which is different from L1, and the symbol Y represents a neutral ligand; where the metal complex or salt C of formula (1) is not zinc diacetylacetonate.
    Type: Grant
    Filed: October 12, 2009
    Date of Patent: August 26, 2014
    Assignee: Bluestar Silicones France SAS
    Inventors: Christian Maliverney, Laurent Saint-Jalmes
  • Publication number: 20140221679
    Abstract: The invention provides a method for producing organic carbonates via the reaction of alcohols and carbon monoxide with oxygen adsorbed on a metallic gold or gold alloy catalyst.
    Type: Application
    Filed: July 16, 2012
    Publication date: August 7, 2014
    Applicant: President and Fellows of Harvard College
    Inventors: Cynthia M. Friend, Robert J. Madix, Bingjun Xu
  • Patent number: 8796345
    Abstract: A method to form a urethane material, the method comprises blending and reacting at least one isocyanate, at least one isocyanate reactive compound and a metallized polyhedral oligomeric silsesquioxane to provide said urethane material, the metallized polyhedral oligomeric silsesquioxane is a dimeric structure with general formula wherein M represents a metal providing a 6-coordinated metal center, x and y being 1, R1O and R2O represent an alkoxide bridging the 6-coordinated metal centers, R3OH and R4OH represent an alcohol ligand and each of R5, to R18 is selected from the group consisting of alkyl-, polyether- and polyester ligands.
    Type: Grant
    Filed: December 8, 2010
    Date of Patent: August 5, 2014
    Assignee: Huntsman International LLC
    Inventors: Rene Alexander Klein, Christina Marinus, Chris Ian Lindsay, Hendrikus Abbenhuis, Jos Wilting, Gijsbert Gerritsen
  • Patent number: 8791223
    Abstract: Methods of catalyzing chemical reactions are provided. A tri-substituted phosphine having at least one substituent that is an alkyl group is added as a catalyst to reaction mixtures. Reaction mixtures contain uretdiones, anhydrides, or isocyanate functional materials including isocyanurates, in various combinations with hydroxyl, thiol, and/or amine functional materials. Curable compositions comprising these catalysts and reaction mixtures are also provided.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: July 29, 2014
    Assignee: PPG Industries Ohio, Inc.
    Inventors: Michael Zalich, Mark P. Bowman, Jonathan T. Martz, Stephen John Thomas, Gregory J. McCollum
  • Publication number: 20140154183
    Abstract: What is described are the compounds and the synthesis of [F-18]-labelled L-glutamic acid, [F-18]-labelled L-glutamate, their derivatives of the formula (I) and their use.
    Type: Application
    Filed: February 5, 2014
    Publication date: June 5, 2014
    Inventors: Matthias FRIEBE, Heribert SCHMITT-WILLICH, Matthias BERNDT, Ludger DINKELBORG, Norman KOGLIN, Keith GRAHAM
  • Patent number: 8664420
    Abstract: A process for producing zinc toluenesulfonate comprising reacting a zinc compound comprising Zn(OH)2 with toluenesulfonic acid and/or a salt thereof in the presence of an alcohol having 1 to 20 carbon atoms in total at a temperature higher than 60° C.
    Type: Grant
    Filed: January 7, 2011
    Date of Patent: March 4, 2014
    Assignee: Mitsui Chemicals, Inc.
    Inventors: Kazuhiro Kosumi, Takeshi Fukuda, Masaaki Sasaki
  • Patent number: 8637696
    Abstract: The invention provides novel compounds and methods to carry out organocatalytic Michael additions of aldehydes to nitroethylene catalyzed by a proline derivative to provide ?-substituted-?-nitroaldehydes. The reaction can be rendered enantioselective when a chiral pyrrolidine catalyst is used, allowing for Michael adducts in nearly optically pure form (e.g., 96-99% e.e.). The Michael adducts can bear a single substituent or dual substituents adjacent to the carbonyl. The Michael adducts can be efficiently converted to protected ?2-amino acids, which are essential for systematic conformational studies of ?-peptide foldamers.
    Type: Grant
    Filed: September 17, 2012
    Date of Patent: January 28, 2014
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Samuel Helmer Gellman, Yonggui Chi, Li Guo
  • Patent number: 8623913
    Abstract: The invention is directed to a method of treating restless legs syndrome in a subject, comprising administering a therapeutically effective amount of a carbamate compound, or pharmaceutically acceptable salt or amide thereof.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: January 7, 2014
    Assignee: SK Biopharmaceuticals Co., Ltd.
    Inventors: Susan Marie Melnick, Duncan Paul Taylor
  • Publication number: 20140004243
    Abstract: The present invention provides a compound having a salty taste enhance activity, and a salty taste enhancer containing the compound, and the like. The present invention relates to a salty taste enhancer for a food or drink, which contains a compound represented by the following formula: wherein each symbol is as defined in the specification, or an edible salt thereof.
    Type: Application
    Filed: September 6, 2013
    Publication date: January 2, 2014
    Applicant: AJINOMOTO CO., INC.
    Inventors: Yuki TAHARA, Yusuke Amino, Takami Maekawa, Yuzuru Eto, Takashi Miyaki, Wakana Saikawa, Yuko Kai, Yutaka Ishiwatari
  • Publication number: 20130338210
    Abstract: A method for delivering a nucleic acid to a cell can include exposing sample cells to a composition which includes charged lipids.
    Type: Application
    Filed: December 7, 2010
    Publication date: December 19, 2013
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Muthiah Manoharan, Khallanthottathil G. Rajeev, Muthusamy Jayaraman, David Butler, Mamta Kapoor, Rajesh Kumar Kainthan
  • Publication number: 20130324539
    Abstract: Improved methods of treating multiple sclerosis and/or psoriasis using prodrugs of methyl hydrogen fumarate are disclosed. The methods comprise administering certain prodrugs of methyl hydrogen fumarate. The methods are able to achieve high blood plasma concentrations of the active metabolite, methyl hydrogen fumarate, without causing significant gastrointestinal irritation. New prodrugs of methyl hydrogen fumarate are also disclosed.
    Type: Application
    Filed: May 30, 2013
    Publication date: December 5, 2013
    Inventors: Peter A. Virsik, David J. Wustrow, Thamil Annamalai
  • Patent number: 8598297
    Abstract: Prepolymers are prepared by a reaction of a polyisocyanate and a hydroxylmethyl containing polyester polyol derived from a fatty acid. The prepolymers can be prepared having isocyanate, hydroxyl, or a variety of other reactive functional groups. The prepolymers are useful in making polyurethanes and other polymers, or a crosslinking agents.
    Type: Grant
    Filed: October 24, 2005
    Date of Patent: December 3, 2013
    Assignee: Dow Global Technologies LLC
    Inventors: Erdem Bedri, Debkumar Bhattacharjee, John N. Argyropoulos
  • Publication number: 20130313669
    Abstract: A coating film forming composition includes an amino acid generator including a protecting group that is eliminated to generate an amino acid. A coating film forming composition includes a component (A): the amino acid generator; a component (B): a hydrolyzable silane, a hydrolysis product thereof, a hydrolysis-condensation product thereof, or a mixture thereof; and a component (C): a solvent.
    Type: Application
    Filed: July 15, 2013
    Publication date: November 28, 2013
    Applicant: Nissan Chemical Industries, Ltd.
    Inventors: Taku KATO, Junpei KOBAYASHI, Satoko TAKANO, Naoki SAKUMOTO
  • Patent number: 8580887
    Abstract: The present invention relates to new, urethane-group-containing polyisocyanates based on aliphatic and/or cycloaliphatic diisocyanates, and to their use.
    Type: Grant
    Filed: July 28, 2011
    Date of Patent: November 12, 2013
    Assignee: BASF SE
    Inventors: Oihana Elizalde, Frederic Lucas, Angelika Maria Steinbrecher, Lydie Tuchbreiter
  • Publication number: 20130230501
    Abstract: A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof, wherein A represents a C3 to C12 cycloalkyl group which may be substituted by one to three selected from a fluoro group, a hydroxy group, a C1 to C6 alkyl group, etc; R1, R2, and R3 each independently represent a hydrogen atom, a fluoro group, or a C1 to C6 alkyl group; R4 represents a hydrogen atom or a prodrug group; and Y represents —CH2—CHR5—CH2—NHR6 (wherein R5 represents a hydrogen atom, a C1 to C6 alkyl group, or a C1 to C6 alkoxy group, and R6 represents a hydrogen atom or a prodrug group), or the like exhibits excellent TAFIa inhibitory activity and is useful as a therapeutic drug for myocardial infarction, angina pectoris, acute coronary syndrome, cerebral infarction, deep vein thrombosis, pulmonary embolism, and the like.
    Type: Application
    Filed: July 16, 2012
    Publication date: September 5, 2013
    Applicant: Daiichi Sankyo Company, Limited
    Inventors: Tsutomu Nagata, Masahiro Inoue, Yuka Ashida, Kengo Noguchi, Makoto Ono
  • Publication number: 20130178645
    Abstract: A method for producing a carbonyl compound of the present invention comprises a step (X) of reacting a specific compound having a urea bond with a carbonic acid derivative having a carbonyl group (—C(?O)—) under heating at a temperature equal to or higher than the thermal dissociation temperature of the urea bond to obtain the carbonyl compound.
    Type: Application
    Filed: February 21, 2012
    Publication date: July 11, 2013
    Applicant: ASAHI KASEI CHEMICALS CORPORATION
    Inventors: Masaaki Shinohata, Nobuhisa Miyake
  • Publication number: 20130149243
    Abstract: This invention relates to methods, which provide access to F-18 labeled glutamic acid derivatives.
    Type: Application
    Filed: November 6, 2010
    Publication date: June 13, 2013
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Mathias Berndt, Heribert Schmitt-Willich, Matthias Friebe, Keith Graham, Thomas Brumby, Christina Hultsch, Hans-Jürgen Wester, Franziska Wagner
  • Publication number: 20130144057
    Abstract: (Meth)acrylic acid ester, which contains one or more partial structures each represented by the following formula 1 in a molecule thereof, wherein the partial structure is a urethane structure which does not have a hydrogen atom directly bonded to a nitrogen atom of the following formula 1: where the nitrogen atom is not bonded to a hydrogen atom.
    Type: Application
    Filed: November 28, 2012
    Publication date: June 6, 2013
    Inventor: Mitsunobu MORITA
  • Publication number: 20130129646
    Abstract: The present invention relates to the cosmetic, dermatological or pharmaceutical (therapeutic) use of compounds of formula (I) or a cosmetically acceptable salt of a compound of formula (I) or a mixture containing two or more of these compounds or the salts thereof wherein R1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R1 and R2 are covalently bonded to one another, preferably so that a 3 to 8 membered ring is formed, for the lightening of skin and/or hair. The invention further relates to compositions and cosmetic, dermatological or pharmaceutical preparations (compositions) comprising one or more compounds of formula (I) suitable for lightening human skin and/or hair and corresponding methods.
    Type: Application
    Filed: May 25, 2010
    Publication date: May 23, 2013
    Inventors: Gabriele Vielhaber, Heiko Oertling, Karin Schaper, Claudia Gömann, Rahim Brodhage
  • Publication number: 20130102780
    Abstract: The present disclosure provides processes for the N-dealkylation of tertiary amines and the use of transition metal catalysts to prepare tertiary N-allyl amine derivatives and secondary amine derivatives thereof. The tertiary amines can be alkaloids and, more particularly, the tertiary amines can be opioids. In specific embodiments, the present disclosure provides methods for use in processes for the synthesis of naloxone and naltrexone from oripavine.
    Type: Application
    Filed: December 11, 2012
    Publication date: April 25, 2013
    Applicant: Rhodes Technologies
    Inventor: Rhodes Technologies
  • Publication number: 20130102806
    Abstract: A rare earth metal extractant containing, as the extractant component, dialkyldiglycol amide acid which is excellent in breaking down light rare earth elements is reacted in diglycolic acid (X mol) and an esterification agent (Y mol) at a reaction temperature of 70° C. or more and for a reaction time of one hour or more such that the mol ratio of Y/X is 2.5 or more, and is subjected to vacuum concentration. Subsequently, a reaction intermediate product is obtained by removing unreacted products and reaction residue, and an aprotic polar solvent is added as the reaction solvent. Then, the reaction intermediate product is reacted with dialkyl amine (Z mol) such that the mol ratio of Z/X is 0.9 or more and the aprotic polar solvent is removed. As a consequence, a rare earth metal extractant is efficiently synthesized at a low cost and at a high yield without having to use expensive diglycolic acid anhydride and harmful dichloromethane.
    Type: Application
    Filed: July 1, 2011
    Publication date: April 25, 2013
    Applicants: JAPAN ATOMIC ENERGY AGENCY, SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Kazuaki Sakaki, Hiroto Sugahara, Tetsuya Kume, Masaki Ohashi, Hirochika Naganawa, Kojiro Shimojo
  • Publication number: 20130079546
    Abstract: A method for producing carbamate including a urea production step; a carbamate-forming step: an ammonia separation step of absorbing the gas with water in the presence of carbonate to produce a gas absorption water, and separating ammonia; an aqueous alcohol solution separation step of separating an aqueous alcohol solution from the gas absorption water; an ammonia/carbon dioxide separation step of separating carbon dioxide gas from the aqueous ammonia solution in the gas absorption water from which the aqueous alcohol solution is separated; an aqueous ammonia solution reusing step of mixing the aqueous ammonia solution and carbonate with the water to be used for production of the gas absorption water.
    Type: Application
    Filed: May 19, 2011
    Publication date: March 28, 2013
    Applicant: MITSUI CHEMICALS, INC
    Inventors: Koji Takamatsu, Satoshi Kato, Takeshi Fukuda, Tetsuya Nakano, Masaaki Sasaki
  • Publication number: 20130041156
    Abstract: This invention relates to novel compounds that are azapeptides, and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel azapeptide compounds that are derivatives of the HIV protease inhibitor atazanavir sulfate. This invention also provides pyrogen-free compositions comprising one or more compounds of the invention and a carrier, and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are treated by administering HIV protease inhibitors. The invention also relates to the use of one or more of the disclosed compounds as reagents in analytical studies involving atazanavir.
    Type: Application
    Filed: August 27, 2012
    Publication date: February 14, 2013
    Inventors: Scott L. Harbeson, Roger D. Tung
  • Publication number: 20130030210
    Abstract: The invention provides novel compounds and methods to carry out organocatalytic Michael additions of aldehydes to nitroethylene catalyzed by a proline derivative to provide ?-substituted-?-nitroaldehydes. The reaction can be rendered enantioselective when a chiral pyrrolidine catalyst is used, allowing for Michael adducts in nearly optically pure form (e.g., 96-99% e.e.). The Michael adducts can bear a single substituent or dual substituents adjacent to the carbonyl. The Michael adducts can be efficiently converted to protected ?2-amino acids, which are essential for systematic conformational studies of ?-peptide foldamers.
    Type: Application
    Filed: September 17, 2012
    Publication date: January 31, 2013
    Applicant: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Samuel Helmer GELLMAN, Yonggui CHI, Li GUO
  • Publication number: 20130022587
    Abstract: A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof, wherein A represents a C3 to C12 cycloalkyl group which may be substituted by one to three selected from a fluoro group, a hydroxy group, a C1 to C6 alkyl group, etc; R1, R2, and R3 each independently represent a hydrogen atom, a fluoro group, or a C1 to C6 alkyl group; R4 represents a hydrogen atom or a prodrug group; and Y represents —CH2—CHR5—CH2—NHR6 (wherein R5 represents a hydrogen atom, a C1 to C6 alkyl group, or a C1 to C6 alkoxy group, and R6 represents a hydrogen atom or a prodrug group), or the like exhibits excellent TAFIa inhibitory activity and is useful as a therapeutic drug for myocardial infarction, angina pectoris, acute coronary syndrome, cerebral infarction, deep vein thrombosis, pulmonary embolism, and the like.
    Type: Application
    Filed: July 16, 2012
    Publication date: January 24, 2013
    Applicant: Daiichi Sankyo Company, Limited
    Inventors: Tsutomu Nagata, Masahiro Inoue, Yuka Ashida, Kengo Noguchi, Makoto Ono
  • Patent number: 8350097
    Abstract: A (?)-stereoisomer of formula (I): (formula I), wherein X is H or F; or a pharmaceutically acceptable salt or pro drug thereof, is useful as an anesthetic.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: January 8, 2013
    Assignee: Signature Therapeutics, Inc.
    Inventor: Thomas E. Jenkins
  • Publication number: 20120330030
    Abstract: Provided is an enantioselective, palladium-catalyzed method for the preparation of ?-amino-?,?-unsaturated carboxylic acid derivatives having the formulas II, III, VII and VIII:
    Type: Application
    Filed: September 6, 2012
    Publication date: December 27, 2012
    Inventors: Murat Acemoglu, Andreas Pfaltz, Claude Shaerer
  • Publication number: 20120329888
    Abstract: Method of producing a nanoparticle suspension with the steps (i) preparation of an emulsion of a disperse polar phase, where the aqueous phase comprises one or more precursor substances forming the nanoparticles, in a continuous organic phase in the presence of an emulsifier stabilizing the emulsion, (ii) conversion of the one or more precursor substances to nanoparticles in the disperse aqueous phase, (iii) breaking of the emulsion and phase separation, where the nanoparticle suspension is obtained as one phase, (iv) separation off of the nanoparticle suspension, (v) optionally isolation of the nanoparticles from the nanoparticle suspension, wherein the emulsifier is selected from compounds of the general formula (I) in which X is O, NH, Y is C(O), NH, R is a saturated or a mono- or polyunsaturated, linear or branched hydrocarbon radical having 6 to 30 carbon atoms and R1 is hydrogen or C1-C4-alkyl, and R2 is a saturated or a mono- or polyunsaturated, linear or branched hydrocarbon radical having 1 to 30 car
    Type: Application
    Filed: March 7, 2011
    Publication date: December 27, 2012
    Applicant: BASF SE
    Inventors: Robert Engel, Wolfgang Gerlinger, Stefan Braese, Thierry Muller, Christina Belenki, Heike P. Schuchmann, Marion Gedrat
  • Patent number: 8338634
    Abstract: The present invention pertains to a catalyst for the synthesis of organic alkyl carbamates, the method for preparing the same and the use thereof. The catalyst comprises a catalytically active component and a catalyst support, and the catalytically active component being carried by the catalyst support, wherein the catalytically active component comprises a transition metal oxide, and the general formula of the transition metal oxide is EOx, wherein E is selected from transition metal element and x is in the range of 0.5-4.
    Type: Grant
    Filed: February 13, 2009
    Date of Patent: December 25, 2012
    Assignee: Bayer MaterialScience AG
    Inventors: Youquan Deng, Yubo Ma, Liguo Wang, Xiaoguang Guo, Shiguo Zhang, Yude He, Stefan Wershofen, Stephan Klein, Zhiping Zhou
  • Publication number: 20120316358
    Abstract: Provided is a method for producing a compound expressed by the following formula (3): [where R1 represents a hydrogen atom or C1-4 alkyl group, and R2 represents C1-4 alkyl group, C1-4 alkoxy group, aryl group, aryloxy group or benzyloxy group], the method comprising a reaction of dehydro-condensing a compound expressed by the following formula (1) and a compound expressed by the following formula (2): while being converted to a desired geometric isomer in the presence or absence of an acid catalyst, under a condition that an organic solvent to be used for the reaction is a mixed solvent of acetic acid and a solvent selected from the group consisting of toluene, xylene and chlorobenzene.
    Type: Application
    Filed: June 14, 2011
    Publication date: December 13, 2012
    Applicant: MEIJI SEIKA PHARMA CO., LTD.
    Inventors: Takashi Ando, Nobuto Minowa, Masaaki Mitomi
  • Publication number: 20120311923
    Abstract: The present invention relates to a gasohol fuel composition that prevents corrosion of the metallurgies involved in fuel storage tanks, vehicle fuel tanks, fuel distribution systems, and transportation systems. The novel gasohol fuel composition comprises of a major portion of an alcohol blended gasoline fuel and a minor portion of a corrosion inhibitor formulation, wherein the corrosion inhibitor formulation comprises of (i) a reaction product of (a) a monosaturated fatty acid; and (b) an azomethine compound derived from a condensation reaction between a carbonyl compound and an amine compound; (ii) a fatty acid oil or ester selected from a group comprising of castor oil, palm oil, soyabean oil, and methyl soya ester; (iii) a dispersing agent, the dispersing agent being a sulfonate compound; and (iv) a viscosity reducing agent selected from a group comprising of ethanol, isopropanol, and propargyl alcohol.
    Type: Application
    Filed: September 3, 2010
    Publication date: December 13, 2012
    Inventors: Jaya Rawat, Venkat Chalapathi Rao Peddy, Venkateswarlu Choudary Nettem, Mohammad Amir Siddiqui
  • Publication number: 20120302782
    Abstract: There is provided a process for preparing a carbamate compound, which is easy and commercially advantageous in that a carbamate compound can be produced with high yield from an amine compound and a carbonate compound. A process for preparing a carbamate compound which comprises the step of reacting an amine compound which has at least one amino group per molecule wherein the amine compound is selected from the group consisting of an aliphatic amine which may be substituted by an alicyclic group or an aromatic group or which may be interrupted by an alicyclic group or an aromatic group, and an alicyclic amine which may be substituted by an aliphatic group, with a carbonate compound in the presence of at least one organic solvent selected from the group consisting of a saturated cyclic hydrocarbon, an unsaturated cyclic hydrocarbon, and a non-cyclic ether by using a hydrolase.
    Type: Application
    Filed: January 6, 2011
    Publication date: November 29, 2012
    Inventors: Yasuhito Yamamoto, Yasutaka Yoshida, Mayumi Araki
  • Publication number: 20120296021
    Abstract: An N-allyl carbamate compound which is suitable as an additive is proposed, the chemical main body thereof allowing modifications of the overall structure of the compound in order to ensure sufficiently high compatibility with as many binder systems as possible, wherein the UV-crosslinkable double bond is designed to be as sterically undemanding as possible, linked via flexible bonds, and highly reactive. In the N-allyl carbamate compound of general formula (A) according to the invention, the radical R1 is selected from straight-chain, branched, or cyclic substituted aliphatic hydrocarbon radicals and heterocyclic radicals, wherein the radical R1 includes at least one ethylenically unsaturated bond, wherein R2, R3, and R4 are selected from hydrogen and hydrocarbon radicals, wherein R5 represents hydrogen or an allyl group, and wherein c is an integer of 1 or greater.
    Type: Application
    Filed: May 30, 2012
    Publication date: November 22, 2012
    Applicant: Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V
    Inventors: Heinz Greisiger, Marc Entenmann, Thadeus Schauer
  • Publication number: 20120259134
    Abstract: A process for producing zinc toluenesulfonate comprising reacting a zinc compound comprising Zn(OH)2 with toluenesulfonic acid and/or a salt thereof in the presence of an alcohol having 1 to 20 carbon atoms in total at a temperature higher than 60° C.
    Type: Application
    Filed: January 7, 2011
    Publication date: October 11, 2012
    Inventors: Kazuhiro Kosumi, Takeshi Fukuda, Masaaki Sasaki
  • Publication number: 20120252892
    Abstract: The invention is directed to a method of treating fibromyalgia syndrome in a subject, comprising administering a therapeutically effective amount of a carbamoyl compound, or pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: November 1, 2010
    Publication date: October 4, 2012
    Inventors: Sung James Lee, Susan Marie Melnick