Abstract: The present invention includes a method for carbamoylating an alcohol with sodium cyanate in the presence of methanesulfonic acid. The reaction can be conducted under anhydrous conditions. This method is suitable for carbamoylating a molecule including both an alcohol moiety and a basic moiety and/or a molecule including both an alcohol moiety and a sulfenyl moiety, such as the sulfenyl alcohol precursor of the antiviral agent Capravirine.
Abstract: The present invention relates to polyisocyanate mixtures prepared from aliphatic and/or cycloaliphatic diisocyanates and having
a) an average isocyanate functionality of at least 2.0,
b) a content of isocyanate groups (calculated as NCO; molecular weight=42) of 4.0 to 28.0 wt. % and
c) a content of alkoxy groups having up to 36 carbon atoms of 2.0 to 37.5 wt. %,
wherein the alkoxy groups are constituents of allophanate groups or optionally urethane groups, provided that >50 mol % of the alkoxy groups are a constituent of allophanate groups that are connected to at least two polyisocyanate molecules which are each prepared from at least two diisocyanates. The present invention also relates to a process for preparing these polyisocyanate mixtures and to coating compositions, which are highly diluted or dilutable with non-polar solvents and contain these polyisocyanate mixtures and lacquer binders or binder components optionally containing isocyanate-reactive groups.
Abstract: Methods of synthesizing pharmacologically useful oxazolidinones are disclosed, and, in particular, a method of manufacturing a 5-(tert-butylcarbamoyl)-aminomethyl-oxazolidinone by condensing a carbamate with a tert-butylcarbamoyl protected derivative of glycidylamine or 3-amino-1-halopropanol.
Abstract: There are disclosed bisoxime ether derivatives of the formula I
in which the variables have the following meanings:
R1 is halogen, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy or C1-C4-haloalkoxy;
n is 1 to 5, it being possible for the radicals R1 to be different if n is other than 1;
R2 is C1-C4-alkyl, C3-C6-alkenyl or C3-C6-alkynyl, it being possible for these groups to be partially or fully halogenated;
Q is C(═CHOCH3)—COOCH3, C(═CHCH3)—COOCH3, C(═NOCH3)—COOCH3 or C(═NOCH3)13 CONHCH3;
and salts thereof, processes and intermediates for the preparation of these compounds, and their use for controlling animal pests and harmful fungi.
Type:
Grant
Filed:
November 2, 2000
Date of Patent:
July 2, 2002
Assignee:
BASF Aktiengesellschaft
Inventors:
Herbert Bayer, Roland Götz, Michael Keil, Hubert Sauter, Oliver Cullmann, Markus Gewehr, Wassilios Grammenos, Andreas Gypser, Bernd Müller, Arne Ptock, Eberhard Ammermann, Thomas Grote, Gisela Lorenz, Siegfried Strathmann, Volker Harries
Abstract: Organic diurethanes and/or polyurethanes are prepared by reacting organic diamines and/or polyamines (a) with urea and/or alkyl cabamates (b) and alcohols (c) in the presence of soluble zirconium compounds, preferably zirconium alkoxides, zirconium acetate or zirconium acetylacetonate, as catalyst (d). They can be used for preparing diisocyanates and/or polyisocyanates by thermal dissociation.
Type:
Grant
Filed:
May 7, 1998
Date of Patent:
June 25, 2002
Assignee:
BASF Aktiengesellschaft
Inventors:
Gerhard Laqua, Ulrich Schoner, Andreas Otterbach, Hans Volkmar Schwarz
Abstract: Process for preparing optically active &bgr;-amino alcohols represented by a general formula (2): Ra—C*H(OH)—C*H(Rb)—Rc wherein Ra and Rc are each independently hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, Rb is one member selected from among groups represented by the following general formulae; (3) R1CO(R2)N—, and (4) R1CO(R1′CO)N—, and C* is an asymmetric carbon atom, characterized by reacting a racemic &agr;-aminocarbonyl compound represented by the general formula (1): Ra—CO—CH(Rb)—Rc, with hydrogen in the presence of an optically active transition metal compound represented by a general formula (7): MaXY(Px)m(Nx)n wherein Ma represents a metal atom belonging to VIII-group of the periodic law, X and Y represent each independently hydrogen, halogeno, Px represents a phosphine ligand, Nx represents an amine ligand, at least one of Px and Nx is optically active, and m and n each independently represent 0 or an integer of 1 th
Abstract: Process for the preparation of amino acid derivatives of the general formula I
where R1-R4 are as defined herein,
from the corresponding malonic acid monoester amides of the general formula II
by Hofmann degradation using a hypohalite in an aqueously basic medium, which comprises carrying out the reaction in the presence of an alcohol or amine and using the hypohalite in amounts of from 1.0 to 1.5 equivalents and the base in amounts of from 0.8 to 4.0 equivalents per mole of starting material II.
Abstract: The present invention provides a compound that includes an active therapeutic agent attached to a blocking moiety that is sensitive to the catalytic action of molecules having retro-aldol and retro-Michael catalytic activity, methods for making such compounds and methods of converting such compounds to active therapeutic agents using molecules having aldolase activity.
Type:
Application
Filed:
June 18, 2001
Publication date:
May 16, 2002
Applicant:
The Scripps Research Institute
Inventors:
Carlos F. Barbas, Doron Shabat, Christoph Rader, Benjamin List, Richard A. Lerner
Abstract: The storage of alkylaminoalkyl (meth)acrylate is made in a container made of stainless steel whose wall surface has not more than 1.6 &mgr;m for the Ra defined in JIS B 0601. And the compound is stored in a container having a water concentration of not more than 0.1 vol. % and a molecular oxygen concentration exceeding 0 to 10 vol. % in the gas phase part of the container.
When the compound is handled under these conditions, it is enabled to retain the (meth)acrylic acid concentration therein below 0.1 wt. %, prevented from producing a polymer or a precipitate, and precluded from coloration.
Abstract: A method of preparing hydroxyalkylcarbamates from six-membered cyclic carbonates. The method involves reacting a six-membered cyclic carbonate with anhydrous ammonia or aqueous ammonium hydroxide. The present invention also provides for hydroxyalkylcarbamates prepared from six-membered cyclic carbonates, and for coating compositions comprising hydroxyalkylcarbamates prepared according to the present invention.
Type:
Application
Filed:
May 23, 2001
Publication date:
April 4, 2002
Inventors:
John H. Clements, Howard P. Klein, Edward T. Marquis, James R. Machac
Abstract: A process for producing &agr;-aminohalomethyl ketones or N-protected &agr;-aminohalomethyl ketones from specified 3-oxazolidin-5-one derivatives via 5-halomethyl-5-hydroxy-3-oxazolidine derivatives. By this process, &agr;-aminohalomethyl ketones and compounds relating to them can be obtained efficiently and economically in industrial scale.
Abstract: The &bgr;-hydroxy carbamate, ethylenically unsaturated monomer of the invention can be polymerized as a homopolymer or copolymerized with other monomers. The polymerization can be carried out in an aqueous medium. The &bgr;-hydroxy carbamate monomer is polymerized to form water-soluble homopolymers or, if polymerized as a mixture with one or more comonomers, copolymers that are soluble, emulsifiable, or dispersible in water. The &bgr;-hydroxy carbamate monomer can be used as a replacement monomer for acrylamide.
Abstract: The invention concerns an isocyanate composition at least partially masked, characterized in that it is masked by at least two agents, one of which at least has a non-carbon carboxylic function. The invention is applicable to organic synthesis.
Abstract: A polymeric furanone magenta colorant is disclosed that contains a furanone magenta chromophore having a furanone adduct, the adduct containing at least one alkoxylated phenyl radical, the chromophore further being derived from at least one aromatic aldehyde having a para-nitrogen and containing electron donating groups selected from the group consisting of alkyls, cycloalkyls, and oligomers or polymers derived from alkyleneoxy or aryleneoxy moieties. The colorant can be utilized in resins, waxes and inks.
Abstract: A urea-urethane compound having one or more urea groups and one or more urethane groups in the molecular structure, the number of said urea groups (A) and the number of said urethane groups (B) satisfying the following numerical formula:
Abstract: An adhesive paste, free of water, based on a reaction product of a polyisocyanate component and a co-reactant selected from the group consisting of a polyol, a monofunctional fatty derivative component and mixtures thereof, wherein the reaction product contains moisture reactive isocyanate groups.
Abstract: Carbamate solutions are obtainable by reacting at least one alkanolamine with carbon dioxide in, as solvent, at least one organic compound having a molecular weight of from 60 to 600 and containing at least one hydroxyl group, wherein the carbamate contains at least 0.
Type:
Grant
Filed:
November 12, 1999
Date of Patent:
November 13, 2001
Assignee:
BASF Aktiengesellschaft
Inventors:
Peter Woo, Anke Schulze, Edmund Stadler, Dieter Tintelnot, Udo Hadick, Ralf Hinrichs, Horst Hürkamp, Klaus Sobolewski
Abstract: Unique masked isocyanates well suited for formulation into a variety of coating compositions, for example paint powders, are prepared by condensing an isocyanate with a ring-hydroxylated aromatic compound bearing at least one substituent which comprises a carbonyl or nitrile functional group and the apparent melting point of which being at least 30° C.
Abstract: A method of preparing hydroxyalkylcarbamates from six-membered cyclic carbonates. The method involves reacting a six-membered cyclic carbonate with anhydrous ammonia or aqueous ammonium hydroxide. The present invention also provides for hydroxyalkylcarbamates prepared from six-membered cyclic carbonates, and for coating compositions comprising hydroxyalkylcarbamates prepared according to the present invention.
Type:
Grant
Filed:
September 25, 2000
Date of Patent:
July 17, 2001
Assignee:
Huntsman Petrochemical Corporation
Inventors:
John H. Clements, Howard P. Klein, Edward T. Marquis, James R. Machac, Jr.
Abstract: Amine-terminated urethane oligomer compositions are described that include very high oligomer concentrations. The compositions are melts of the amine-terminated oligomers. The compositions can include one or more property modifiers. The compositions are useful in the formation of crosslinked copolymers, especially with epoxy resins. The resulting copolymers are useful in the formation of coatings.
Type:
Application
Filed:
February 26, 2001
Publication date:
July 12, 2001
Inventors:
Joseph S. Keute, Anne-Marie Thunnissen, Robert J. Tweedy
Abstract: A crosslinking agent comprising one or more carbamate groups or groups convertible to carbamate and two or more polyfunctional amino moieties having the formula
wherein L is selected from the group consisting of alkyl or aryl, cycloalkyl and alkylaryl having a carbon chain length between 1 and 6 carbon atoms and N is a polyfunctional amino moiety. L may also have additional bridging groups such as esters, ethers, ureas, or urethanes groups. Also included is a method of making the crosslinker, a coating composition containing the crosslinker and a method for coating a substrate with the composition.
Type:
Grant
Filed:
December 23, 1996
Date of Patent:
July 10, 2001
Assignee:
BASF Corporation
Inventors:
John W. Rehfuss, Walter H. Ohrbom, Donald L. St. Aubin
Abstract: Organic diurethanes and/or polyurethanes are prepared by reacting organic diamines and/or polyamines (a) with urea and/or alkyl cabamates (b) and alcohols (c) in the presence of soluble zirconium compounds, preferably zirconium alkoxides, zirconium acetate or zirconium acetylacetonate, as catalyst (d). They can be used for preparing diisocyanates and/or polyisocyanates by thermal dissociation.
Type:
Application
Filed:
May 7, 1998
Publication date:
June 28, 2001
Inventors:
GERHARD LAQUA, ULRICH SCHONER, ANDREAS OTTERBACH, HANS VOLKMAR SCHWARZ
Abstract: Derivatives of mutiline of formula (1A) and pharmaceutically acceptable salts and derivatives thereof, in which R1 is ethyl or vinyl, Y is a carbamoyloxy group, in which the N-atom is unsubstituted, or mono- or di-substituted, are useful in the treatment of bacterial infections.
Type:
Grant
Filed:
December 21, 1999
Date of Patent:
May 29, 2001
Assignee:
Smithkline Beecham p.l.c.
Inventors:
Jeremy David Hinks, Andrew Kenneth Takle, Eric Hunt
Abstract: Alternative equilibrium modifiers for use with aldoxime extractants, such as hydroxyl aryl aldoxime extractants, employed in the process for extraction of metal values, particularly copper values, in the extraction from aqueous solutions, in which the extractant and modifiers are employed in an organic solvent phase, the solvent being a water insoluble, water immiscible hydrocarbon solvent, such as a kerosene.
Type:
Grant
Filed:
April 20, 1998
Date of Patent:
May 15, 2001
Assignee:
Henkel Corporation
Inventors:
Michael J. Virnig, Phillip L. Mattison, Leroy O. Krbechek, J. Murdoch Mackenzie
Abstract: Six-membered cyclic carbonates (2-oxo-1,3-ioxanes) in which keto or carbohydrocarbyloxy groups are bound to the 5 position of the ring are disclosed. They react surprising quickly with primary or secondary cyclic amines, and the novel product hydroxyurethanes are usefull as reactive diluents.
Type:
Grant
Filed:
December 13, 1999
Date of Patent:
May 8, 2001
Assignee:
E. I. du Pont de Nemours and Company
Inventors:
Neville E. Drysdale, Mike Fryd, Sapé Quashie
Abstract: The invention concerns a compound of formula (I)
in which m is to 0 or 1 Iso is the (poly)isocyanate radical (after elimination of an isocyanate function); R10 is selected among: a negative charge; a hydrocarbon-based radical (i.e. a residue containing hydrogen and carbon atoms) having a carbon as it binding point [i.e. the atom carrying the open bond ]; R11 is selected among: a negative charge. The invention is applicable to organic synthesis.
Type:
Grant
Filed:
November 12, 1999
Date of Patent:
April 17, 2001
Assignee:
Rhodia Chimie
Inventors:
Jean-Marie Bernard, Thierry Jeannette, Minow Nabavi
Abstract: Azlactone (3), or the opposite enantiomer thereof, undergoes biotransformation, using suitable enzymatic activity, in the presence of a compound YH to form a N-acyl-amino acid (2), wherein R1, R2 and R3 are each not hydrogen and are independently selected from groups containing up to 20 carbon atoms, optionally with any combination of R1, R2 and R3 being joined together to form at least one ring, X is selected from groups containing up to 20 carbon atoms, and Y is selected from the group consisting of —OH, -Oalkyl and -Nalkyl. Amino acid (1), or the opposite enantiomer thereof, can be prepared in high enantiomeric excess from N-acyl amino acid (2), by converting Y to OH.
Type:
Grant
Filed:
August 10, 1998
Date of Patent:
January 30, 2001
Assignee:
Chirotech Technology, Inc.
Inventors:
Nicholas Turner, James Winterman, Raymond McCague
Abstract: Novel monomers of the general formula ##STR1## where b is 0 or 1, a is 1, 2, 3 or 4, R.sup.2 is a monovalent alkyl radical and R is an organic radical. The novel monomers may be employed to produce novel copolymers useful as hydrogel, soft non-hydrogel and/or rigid gas permeable contact lens materials.
Abstract: The present invention relates to compounds containing modified hydrazide groups and corresponding to formula I ##STR1## wherein R represents the residue obtained by removing the isocyanate groups from a monomeric polyisocyanate, a polyisocyanate adduct or an NCO prepolymer,X represents OR' or NHR' andR' represents a group which is inert to isocyanate groups under the conditions used to form the compound of formula I andn has a value of 2 to 6.The present invention also relates to one-component, thermoset coating compositions containing the compounds of formula I and a cross-linking component that is reactive with these compounds. Finally, the present invention relates coatings, sealants and adhesives prepared from these thermoset compositions.
Abstract: Describes a method of producing N-1-alkenyl carbonylamino compounds represented by the following general formula I, ##STR1## wherein R.sub.1 is the residue of an active hydrogen functional material, n is a number from 1 to a number equal to the number of active hydrogen groups of said active hydrogen functional material, X is selected from O, S and N(R.sub.5), R.sub.5 being hydrogen, hydrocarbyl, or R.sub.5 and R.sub.1 may together form a cyclic ring, R.sub.2, R.sub.3 and R.sub.4 are each independently selected from hydrogen, C.sub.1 -C.sub.4 alkyl and C.sub.2 -C.sub.4 alkenyl.
Abstract: Disclosed is a method for the preparation of carbamate compounds substantially free of by-products; the carbamate compounds being prepared by reacting an isocyanate with a hydroxylated compound in the presence of certain catalysts that increase the rate of carbamylation while decreasing the rate of by-product formation.
Abstract: Cationic lipids of general formula (I), wherein m is an integer from 2 to 6 inclusive; n is an integer from 1 to 9 inclusive, preferably 1-5, where, when n is 2-9, a single R grouping other than hydrogen is present in the general formula, and m has variable or identical values within the groupings (a) or --(CH.sub.2).sub.m ; R is a hydrogen atom or a radical of general formula (II), wherein X or X.sup.1, which are the same or different, are an oxygen atom, a methylene grouping --(CH.sub.2).sub.q -- where q is 0, 1, 2 or 3, or an amino grouping --NH-- or NR.sup.1 --, where R is a C.sub.1-4 alkyl grouping; Y and Y.sup.1, which are the same or different, are a hydrogen atom or an optionally substituted C.sub.1-4 alkyl radical, and p is 0-5; and R.sub.6 is a cholesterol derivative or an alkylamino grouping --NR.sub.1 R.sub.2, where R.sub.1 and R.sub.2 are, independently of each other, a straight or branched, saturated or unsaturated C.sub.12-22 aliphatic radical.
Type:
Grant
Filed:
June 4, 1997
Date of Patent:
August 22, 2000
Assignee:
Rhone-Poulenc Rorer S.A.
Inventors:
Gerardo Byk, Daniel Scherman, Catherine Dubertret
Abstract: The present invention provides amine/amide catalysts for use in catalyzing the formation of polyurethane. The amine/amide catalysts, which have low fugitivity due to their reactivity with isocyanates, and good catalytic activity, have the structure ##STR1## wherein Q is C.sub.z H.sub.2z+1, or (CH.sub.2).sub.n N(R.sup.3).sub.k T, T is a monovalent C.sub.1 -C.sub.4 alkyl, amino-C.sub.1 -C.sub.4 -alkyl, mono-C.sub.1 -C.sub.4 -alkylamino-C.sub.1 -C.sub.4 -alkyl, or di-C.sub.1 -C.sub.4 -alkylamino-C.sub.1 -C.sub.4 -alkyl group, or T is a divalent alkyl, amine substituted alkyl, alkylaminoalkyl, or alkoxyalkyl group which forms with the nitrogen atom shown in structure (I) to which T is attached a cyclic structure which incorporates up to 6 carbon atoms in the ring as well as the nitrogen atom shown in structure (I), which cyclic structure may be substituted with C.sub.1 to C.sub.4 alkyl;k=0 or 1, being 1 if T is a monovalent group and 0 if T is a divalent group; R.sup.2 .dbd.H or C.sub.z H.sub.2z+1 ; R.sup.3 .dbd.
Abstract: This invention relates to non-ionic emulsifiers based on fatty acid esters of polyalkoxylated polyhydric alcohols as fundamental constituents. At least two fundamental constituents are linked to each other by the reaction of hydroxyl groups with a polyisocyanate, with the formation of urethane bonds.
Type:
Grant
Filed:
April 10, 1998
Date of Patent:
May 16, 2000
Assignee:
Herberts Gesellschaft mit beschrankter Haftung
Inventors:
Wolfgang Diener, Volker Duecoffre, Carmen Flosbach, Gerhard Hey, Walter Schubert
Abstract: The present invention is directed to a polymeric vehicle, the formulated coating composition and a coating binder made from the polymeric vehicle and a method for making the polymeric vehicle where the polymeric vehicle includes a phenol blocked isocyanate having reactive aliphatic hydroxyl groups. The phenol blocked isocyanate may be made from a phenolic ester alcohol having at least one aliphatic hydroxyl group and one phenolic hydroxyl group.
Type:
Grant
Filed:
August 26, 1996
Date of Patent:
April 18, 2000
Assignee:
Exxon Chemical Patents, Inc.
Inventors:
Albert I. Yezrielev, Frank N. Jones, Ramachandran P. Subrayan, Vijay Swarup
Abstract: This invention provides novel cationic lipids, particularly guanidino lipids, and methods for their preparation. Also provided are polyanionic-lipid complexes comprising the lipids of the invention, their preparation and use to deliver biologically active substances, particularly nucleic acids to cells.
Type:
Grant
Filed:
October 20, 1997
Date of Patent:
March 7, 2000
Assignee:
Syntex (U.S.A.) Inc.
Inventors:
Paula N. Belloni, Donald R. Hirschfeld, John O. Link, John J. Nestor, Jr., Gary A. Peltz
Abstract: Stabilizer precursors and preformed stabilizers having induced unsaturation, and prepared from low intrinsic unsaturation-containing polyoxyalkylene polyether polyols may be used to form polymer polyols of higher solids content, lower viscosity, and superior filterability and particle size than polymer polyols prepared from stabilizers derived from polyols having higher intrinsic unsaturation, even when the latter are coupled to form high molecular weight stabilizers.
Type:
Grant
Filed:
December 16, 1997
Date of Patent:
January 11, 2000
Assignee:
ARCO Chemical Technology L.P.
Inventors:
Ulrich B. Holeschovsky, Donald W. Simroth
Abstract: The reactions of cyclic carbonates, especially 1,3-dioxolan-2-ones, with amines, especially primary amines, are catalyzed by the presence of a base whose conjugate acid has a pKa of about 11 or more. The products are hydroxy urethanes, and the process can be used to form crosslinked polymers which contain urethane groups. Such crosslinked polymers are useful in coatings.
Abstract: The present invention is directed to a polymeric vehicle, the formulated coating composition and a coating binder made from the polymeric vehicle and a method for making the polymeric vehicle where the polymeric vehicle includes a phenolic urethane reactive diluent. The phenolic urethane reactive diluent may be made from a phenolic ester alcohol having at least one aliphatic hydroxyl group.
Type:
Grant
Filed:
March 21, 1996
Date of Patent:
October 26, 1999
Assignee:
Exxon Chemical Patents, Inc.
Inventors:
Frank N. Jones, Vijay Swarup, Ramachandran P. Subrayan, Suru Zhang
Abstract: A method of preparing carbamates by reacting amine with alcohol and mixed gas of CO/O.sub.2 in the presence of one or more catalyst selected from the group consisting of monovalent copper halide having the structural formula of Cu?NCMe.sub.4 !X, K?CuX.sub.2 !, ?CuX(S)! (wherein X=Cl, Br, or I; S=solvent) or monovalent copper compound having carbonyl group having the structural formula of ?Cu(CO)X.sub.a L.sub.b !.sub.m Y.sub.n (wherein, X=CF.sub.3 CO.sub.2, Cl, HB(pz).sub.3 (wherein, pz=pyrazoyl,C.sub.3 H.sub.3 N.sub.2), LBF.sub.2, {LBF.sub.2 =difluoro-3,3'-(trimethylenedinitrilo)bis(2-butanone oximato)borate}; L=en, diene; Y=BPh.sub.4, AsF.sub.6 ; a,b=0,1; m=1-4; n=0,1).
Type:
Grant
Filed:
April 29, 1998
Date of Patent:
October 5, 1999
Assignee:
Korea Institute of Science and Technology
Inventors:
Hoon Sik Kim, Sang Deuk Lee, Hyun-joo Lee, In-Seok Seo, Yong Jin Kim
Abstract: The invention relates to non-crystallising, amine-blocked polyisocyanates, to the preparation thereof and to their in one-component polyurethane stoving compositions, in particular for coil-coating applications.
Type:
Grant
Filed:
September 2, 1998
Date of Patent:
October 5, 1999
Assignee:
Bayer Aktiengesellschaft
Inventors:
Eberhard Konig, Karl-Ludwig Noble, Christian Fussel
Abstract: A hydrolytically unstable, biocompatible polymer capable of carrying and releasing a pharmaceutical compound when introduced into physiological media. In a preferred embodiment, the polymer contains ester linkages that are susceptible to hydrolytic degradation. A monomeric unit of the polymer can also be used as a hydrolytically unstable linking agent for quickening the degradation of polymers, particularly cross-linked polymers.
Abstract: Disclosed is an acid-funtionalized polyurethane adduct and a process for the preparation of such adduct. The adduct having a linear or preferably branched structure comprises a plurality of internal urethane linkages and one or more terminal carboxylic acid groups per molecule. Such acid-funtionalized polyurethane adducts find value in the manufacture of crosslinked aqueous rubber latexes such as might be used in paint compositions.
Type:
Grant
Filed:
February 19, 1997
Date of Patent:
August 10, 1999
Assignee:
The Dow Chemical Company
Inventors:
Michael J. Elwell, Hanno R. van der Wal, Camiel F. Bartelink, Henri J. Grunbauer
Abstract: The present invention provides the compound having the structure: ##STR1## wherein each of R.sub.1 and R.sub.2 are independently the same as or different from each other; when R.sub.1 and R.sub.2 are the same, each is a substituted or unsubstituted arylamino, cycloalkylamino, pyridineamino, piperidino, 9-purine-6-amine, or thiozoleamino group; when R.sub.1 and R.sub.2 are different, R.sub.1 =R.sub.3 --N--R.sub.4, wherein each of R.sub.3 and R.sub.4 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted, branched or unbranched alkyl, alkenyl, cycloalkyl, aryl, alkyloxy, aryloxy, arylalkyloxy, or pyridine group, or R.sub.3 and R.sub.4 bond together to form a piperidine group and R.sub.2 is a hydroxylamino, hydroxyl, amino, alkylamino, dialkylamino or alkyloxy group; and n is an integer from about 4 to about 8.
Type:
Grant
Filed:
April 4, 1994
Date of Patent:
August 3, 1999
Assignees:
Sloan-Kettering Institute for Cancer Research, The Trustees of Columbia Univerisity in the City of New York
Inventors:
Ronald Breslow, Paul A. Marks, Richard A. Rifkind, Branko Jursic
Abstract: The present invention relates to a process for preparing an isocyanate group-containing allophanate corresponding to formula (I) ##STR1## wherein R represents the residue obtained by removing the isocyanate groups from a (cyclo)aliphatic or araliphatic diisocyanate,Y represents the represents an m-valent residue obtained by removing the hydroxyl groups from a (poly)hydroxyl compound having m OH groups andn and m are the same or different and have a value of 1 to 5, by reacting an isocyanate group-containing oxadiazinetrione with a primary alcohol in the presence of a basic catalyst having a pKa value of >6.
Type:
Grant
Filed:
August 8, 1997
Date of Patent:
June 29, 1999
Assignee:
Bayer Aktiengesellschaft
Inventors:
Klaus Konig, Helmut Reiff, Christian Wamprecht, Harro Traubel
Abstract: An aliphatic diisocyanate compound is prepared in a high yield by reacting dimethyl carbonate with an aliphatic diamine in the presence of an alkali catalyst to produce a corresponding urethane compound; and, within 48 hours after the completion of the preparation of the urethane compound, thermally decomposing the urethane compound under a reduced pressure of 1 to 700 Torr in a high-boiling-point solvent.
Abstract: The present invention relates to a process for the solvent-free production of polyisocyanate addition products, which are suitable as dispersing agents for incorporating solids into aqueous coating compositions, wherein the polyisocyanate addition products have a maximum content of 1% by weight of isocyanate groups and a content of 30 to 95% by weight of ethylene oxide units (molecular weight=44) present in the polyether chains of monofunctional alcohols B), and are prepared by reactingA) a polyisocyanate component having an average NCO functionality of 1.7 to 2.5 and an NCO content of 10 to 65% by weight with one or more of the following components:B) monohydric polyether alcohols having a number average molecular weight of 150 to 5000 and an ethylene oxide content of 40 to 99.
Type:
Grant
Filed:
August 20, 1997
Date of Patent:
June 8, 1999
Assignee:
Bayer Aktiengesellschaft
Inventors:
Christian Wamprecht, Oswald Wilmes, Stephan Kirchmeyer, Jan Mazanek
Abstract: Oxadiazines of formula I, wherein R1 is F, Cl or fluoroalkoxy and R2 is alkyl, are prepared by reacting hydrazine derivatives of formula II with a dialkoxymethane in the presence of a protic acid catalyst in an inert solvent under conditions which allow for the prompt removal of the alcohol by-product by distillation.
The reaction can be combined with the preparation of the hydrazines derivatives II from the corresponding ketones and hydrazines NH2-NHR3 in the presence of the same protic acid catalyst and an inert solvent. Oxadiazines I are useful as intermediates in the preparation of arthropodicidal agents.