Polycarbamic Patents (Class 560/158)
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Patent number: 8431672Abstract: The present invention relates to a method for manufacturing an isocyanate group-terminated prepolymer, comprising the following steps (a) to (d): (a) a step of ring-opening polymerizing an alkyleneoxide-containing cyclic compound by using an initiator in the presence of a composite metal cyanide complex catalyst, thereby obtaining a polyol composition containing the catalyst; (b) a step of, without removal of the composite metal cyanide complex catalyst from the polyol composition obtained in the step (a), adding water and performing a heat treatment in a closed system; (c) a step of subjecting the hydrous polyol composition after the step (b) to a dehydration treatment; and (d) a step of adding a polyisocyanate compound to the polyol composition after the step (c) and subjecting to a reaction with the polyol in the polyol composition.Type: GrantFiled: March 30, 2012Date of Patent: April 30, 2013Assignee: Asahi Glass Company, LimitedInventors: Chitoshi Suzuki, Takeaki Arai, Yukio Matsumoto
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Publication number: 20130072709Abstract: The present invention provides, among other things, segmented, degradable polymeric reagents suitable for reaction with biologically active agents to form conjugates, the polymeric reagents comprising one or more polymer chains divided or separated by one or more degradable linkages into polymer segments having a molecular weight suitable for renal clearance. The polymeric reagents can have a substantially linear structure, a branched structure, or a multiarm structure. Each structure includes one or more linkages capable of degradation in vivo.Type: ApplicationFiled: November 12, 2012Publication date: March 21, 2013Applicant: Nektar TherapeuticsInventor: Nektar Therapeutics
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Publication number: 20130053506Abstract: Provided is a fluorine compound represented by the following general formula (1) which has excellent compatibility with a resin and the like, and can be produced into a coating film having excellent stain-proof properties. Also provided is an active energy ray-curable resin composition using the compound. (In the general formula (1), X1 represents a poly(perfluoroalkylene ether) chain; and R1 to R4 independently represent a hydrogen atom, an alkyl group, following general formula (2) or (3), provided that at least one of R1 and R2 is following general formula (2) or (3) and at least one of R3 and R4 is following general formula (2) or (3).) (In the general formula (2), X2 represents a linear or branched hydrocarbon group; X3 represents an oxygen atom or a sulfur atom; X4 represents a linear or branched alkylene group; R5 represents a hydrogen atom or a methyl group; and p represents an integer of 1 to 5.) (In the general formula (3), X2, X3, R5 and p are as described above.Type: ApplicationFiled: August 3, 2009Publication date: February 28, 2013Applicant: DIC CorporationInventors: Tsuneyuki Ohtaguro, Jun Noguchi, Yohzon Yamashina
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Patent number: 8378139Abstract: A process for oligomerizing isocyanates includes a step of continuous conversion of an isocyanate monomer into polyisocyanate containing carbamate and/or allophanate groups, in the presence of a catalyst, wherein the conversion step is carried out in a reactor having a specific heat exchange coefficient of greater than or equal to approximately 200 kW/m3/° C.Type: GrantFiled: April 2, 2009Date of Patent: February 19, 2013Assignees: Centre National de la Recherche Scientifique (C.N.R.S.), Institut National Polytechnique de Toulouse, Perstorp FranceInventors: Hocine Kabir, Johannes Schwarz, Christophe Gourdon, Sébastien Elgue
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Patent number: 8373004Abstract: The present invention relates to a novel process for preparing colorless, isocyanurate group-comprising polyisocyanates of (cyclo)aliphatic diisocyanates.Type: GrantFiled: March 27, 2008Date of Patent: February 12, 2013Assignee: BASF SEInventors: Harald Schaefer, Carl Jokisch, Horst Binder, Matthias Kroner, Alexander Bayer
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Patent number: 8362300Abstract: The present invention provides addition compounds, which suitable as dispersants and as dispersion stabilizers, and to the salts of the said compounds. The invention further provides processes for preparing these addition compounds, to their use as dispersants and dispersion stabilizers for organic and inorganic pigments and also fillers in organic and aqueous systems, and to pulverous or fibrous solids coated with such dispersants and intended for incorporation into liquid systems.Type: GrantFiled: May 6, 2005Date of Patent: January 29, 2013Assignee: BYK-Chemie GmbHInventors: Wolfgang Pritschins, Udo Krappe, Karlheinz Haubennestel, Andrea Esser
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Patent number: 8334357Abstract: Disclosed is a thickener based on an aqueous preparation of a nonionic, water-dispersible or water-soluble polyurethane, obtained by reacting: (a) hydrophilic polyols containing at least two OH groups and at least two functional groups selected from ether and ester, of molecular weight at least 300; (b) hydrophobic compounds containing at least one zerewitinoff-active hydrogen atom, of molecular weight about 100 to about 500, with at least one linear or branched, saturated or unsaturated alkyl chain having at least five consecutive carbon atoms not linked to a hetero atom; and (c) at least difunctional isocyanates, where the components are reacted in equivalent ratios OHa):ZHb):NCOc) of 1:(1+x):2(1+y), with the provisos that x is 0.05-1.2, y is (0.2-1.05)x, and more than one equivalent of NCOc) is present versus the sum of OHa) and ZHb).Type: GrantFiled: June 22, 2005Date of Patent: December 18, 2012Assignee: Cognis IP Management GmbHInventors: Ludwig Schieferstein, Oliver Pietsch
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Publication number: 20120295228Abstract: Dental compositions and disulfide monomers are described. The disulfide monomer comprise a disulfide backbone group wherein each of the sulfur atoms are bonded to an ethylenically unsaturated group via a divalent linking group and the linking group comprises at least one heteroatom; and at least one other monomer ethylenically unsaturated monomer.Type: ApplicationFiled: May 18, 2011Publication date: November 22, 2012Inventors: Ahmed S. Abuelyaman, Joel D. Oxman, Yizhong Wang, Christopher N. Bowman, Hee Young Park, Christopher J. Kloxin
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Patent number: 8299201Abstract: A one-component polyurethane composition includes at least one polyurethane prepolymer having terminal isocyanate groups which is prepared from at least one polyisocyanate and at least one polyol, and to at least one catalyst system which is obtainable from at least one bismuth compound and at least one aromatic nitrogen compound. The polyurethane composition may be used as an adhesive, sealant, coating or lining. Finally, catalysts for polyurethane compositions are disclosed which represent coordination compounds between bismuth and at least one aromatic nitrogen compound.Type: GrantFiled: October 1, 2003Date of Patent: October 30, 2012Assignee: Sika Technology AGInventors: Urs Burckhardt, Andreas Diener
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Patent number: 8293786Abstract: Described herein are cannabidiol prodrugs, methods of making cannabidiol prodrugs, formulations comprising cannabidiol prodrugs and methods of using cannabidiols. One embodiment described herein relates to the transdermal or topical administration of a cannabidiol prodrug for treating and preventing diseases and/or disorders.Type: GrantFiled: July 30, 2008Date of Patent: October 23, 2012Assignee: Alltranz Inc.Inventors: Audra Lynn Stinchcomb, Miroslaw Jerzy Golinski, Dana Carmel Hammell, Jeffrey Lynn Howard, Stan Lee Banks
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Publication number: 20120264963Abstract: Disclosed is a compound having a photocurable urethane(meth)acrylate group, its manufacturing method, and a photocurable composition including the compound. The compound is represented by Chemical Formulae 1 to 6. Each of Chemical Formulae 1 to 6 includes a urethane(meth)acrylate group represented by Chemical Formula 1-1 or 1-2.Type: ApplicationFiled: June 8, 2012Publication date: October 18, 2012Applicant: SAMSUNG ELECTRONICS CO., LTD.Inventors: Yi Yeol LYU, Chul Ho JEONG, Sun Jin SONG
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Publication number: 20120253061Abstract: A 3D image display apparatus has an image display panel portion that is driven based on image signals, and a phase difference plate that is disposed on an observation side of the image display panel portion and has at least a patterned optically anisotropic layer, in which the image display panel portion and the phase difference plate are adhered to each other through an adhesive composition having a glass transition temperature of room temperature or lower, and at least one of surfaces adhered through the adhesive composition is a film including a cellulose derivative.Type: ApplicationFiled: March 30, 2012Publication date: October 4, 2012Applicant: FUJIFILM CorporationInventor: Keita TAKAHASHI
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Patent number: 8273847Abstract: A medical adhesive comprises a hydrophilic urethane prepolymer (UP) obtained by reacting a fluorine-containing nonaromatic polyisocyanate component (A) and a polyol component (B) having a hydrophilic polyol (B1), and a phenolic radical scavenger (PRS). The content of (PRS) is preferably 0.01 to 3% by weight based on the weight of (UP). The content of oxyethylene groups in (B) is preferably 30 to 100% by weight based on the weight of the oxyalkylene groups in (B). Preferably, (B) is a mixture of a random copolymer obtained by addition of ethylene oxide and propylene oxide to diols and polypropylene glycol. The content of isocyanate groups in the medical adhesive is 1 to 10% by weight based on the weight of (UP). The medical adhesive is suitable for bonding body tissues, such as lung, artery and heart in particular.Type: GrantFiled: March 23, 2005Date of Patent: September 25, 2012Assignee: Sanyo Chemical Industries, LtdInventors: Tetsuji Yoshimura, Tetsuya Yamada, Takehisa Matsuda
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Publication number: 20120228567Abstract: A process of producing a urethane (meth)acrylate monomer having a low acid value and a low content of a hardly soluble high-molecular weight impurity which is crosslinked high-dimensionally, comprising the steps of: (1) contacting a first solution containing a urethane (meth)acrylate monomer having an acid value of more than 0.2 mgKOH/g and an organic solvent to a water-containing adsorbent capable of adsorbing an acid component to obtain a second solution containing a urethane (meth)acrylate monomer having an acid value of not more than 0.2 mgKOH/g, the organic solvent and more than 5,000 ppm (mass) of water based on the urethane (meth)acrylate monomer; (2) contacting the second solution to a dehydrating agent to obtain a third solution containing not more than 5,000 ppm (mass) of water based on the urethane (meth)acrylate monomer; and (3) removing the organic solvent from the third solution.Type: ApplicationFiled: November 16, 2010Publication date: September 13, 2012Inventors: Shinobu Izumi, Mitsuyoshi Sando, Junji Takenaka, Junji Momoda
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Patent number: 8232364Abstract: The present invention relates to improved gel masses prepared from a reaction mixture of NCO prepolymers and selected compounds containing groups reactive towards isocyanate groups. This invention is also directed to a process for the production of these gel masses and to the production of pressure-distributing elements comprising these gel masses.Type: GrantFiled: September 7, 2006Date of Patent: July 31, 2012Assignee: TechnoGel GmbHInventors: Andreas Hoffman, Heinz-Dieter Ebert, Matteo Mason
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Patent number: 8217133Abstract: In one aspect, the invention relates to storage-stable and flowable polyurethane compositions comprising (a) one or more isocyanate-terminated polyurethane prepolymers derived from one or more hydrocarbon ring-containing diisocyanates and/or triisocyanates and one or more polyols; (b) one or more metal salt complexes of methylenedianiline; and (c) one or more organic acid halide compounds having one or more acid halide groups, wherein the one or more organic acid halide compounds are in an amount wherein the acid halide groups are present in a minimum concentration of about 100 parts per million by weight of the polyurethane prepolymer. In other aspects, the invention relates to methods for storing the curable polyurethane compositions, as well as methods for producing polyurethane elastomers.Type: GrantFiled: February 5, 2007Date of Patent: July 10, 2012Assignee: Chemtura CorporationInventors: Phaniraj T. Nagaraj, R. Scott Archibald, Thomas R. Doyle, Ronald O. Rosenberg
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Publication number: 20120157706Abstract: The invention provides methods and compositions for preparing lisdexamfetamine and salts thereof. More particularly, the invention provides, for example, methods of preparing lisdexamfetamine from D-amphetamine.Type: ApplicationFiled: December 20, 2010Publication date: June 21, 2012Inventors: Michael J. Bauer, Gary Richard Callen, Judi Christine Humphrey, Todd Jeffrey Johnson, Matthew Wendell Schiesher
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Publication number: 20120123111Abstract: The present invention relates to physically-chemically and pharmacokinetically enhanced N?-hydroxy-L-arginine (NOHA) derivatives and a method for producing the NOHA derivatives having enhanced physical-chemical and pharmacokinetic properties according to the invention.Type: ApplicationFiled: January 4, 2010Publication date: May 17, 2012Applicant: Christian-Albrechts-Universitaet Zu KielInventors: Bernd Clement, Dennis Schade, Jürke Kotthaus
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Patent number: 8178703Abstract: Methods to convert biobased oils, oil derivatives, and modified oils to highly functionalized esters, ester polyols, amides, and amide polyols. The products can be used to make polyurethane and polyester films and foams.Type: GrantFiled: June 8, 2011Date of Patent: May 15, 2012Assignee: Battelle Memorial InstituteInventors: Herman Paul Benecke, Daniel B. Garbark, Bhima Rao Vijayendran
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Publication number: 20120116115Abstract: A bromine/nitro moiety linked into the backbone of an ester or other compound over a wide range of occurrence rates provides antimicrobial, bio-resistant and fungal resistant properties for metal working fluids (MWF)s and other coatings. The moiety can be have the bromo and nitro groups linked to the same or different carbon atoms. The present invention also relates to urethanes, urea, amides, imides, carbonates, ethers, siloxanes, and many other types of linkages essential to MWF bases.Type: ApplicationFiled: January 17, 2012Publication date: May 10, 2012Inventor: Thomas Daly
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Publication number: 20120116114Abstract: The invention relates to a process for producing polyester polyols with secondary hydroxyl end groups, including the step of the reaction of a polyester including carboxyl end groups with an epoxide of the general formula (1): wherein R1 stands for an alkyl residue or an aryl residue and the reaction is carried out in the presence of a catalyst that includes at least one nitrogen atom per molecule. The process is distinguished in that the polyester including carboxyl end groups exhibits an acid value from ?25 mg KOH/g to ?400 mg KOH/g and a hydroxyl value from ?5 mg KOH/g and in that the polyester including carboxyl end groups is produced by ?1.03 mol to ?1.90 mol carboxyl groups or carboxyl-group equivalents of an acid component being employed per mol hydroxyl groups of an alcohol. The polyester polyols obtained, including secondary hydroxyl end groups, can be used for the purpose of producing polyurethane polymers.Type: ApplicationFiled: May 4, 2010Publication date: May 10, 2012Applicant: Bayer MaterialScience AGInventors: Hartmut Nefzger, Erika Bauer, Jörg Hofmann, Klaus Lorenz, Bert Klesczewski
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Publication number: 20120095177Abstract: The present invention relates to polymeric compositions useful in the manufacture of biocompatible medical devices. More particularly, the present invention relates to certain cationic monomers capable of polymerization to form polymeric compositions having desirable physical characteristics useful in the manufacture of ophthalmic devices. The polymer compositions comprise polymerized fluorinated polyether monomer end-capped with ethylenically unsaturated cationic hydrophilic groups.Type: ApplicationFiled: December 21, 2011Publication date: April 19, 2012Inventors: Derek Schorzman, Jay Kunzier
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Publication number: 20120082959Abstract: Novel polymerizable compounds comprising a polyalicyclic structure element and certain functional groups, mixtures comprising one or a plurality of these compounds and corresponding curable blends and products as well as their respective use as dental material or for the preparation of a dental material are described. A method for preparing these compounds or mixtures and a method for preparing a product, preferably a product suitable for dentistry, are also described.Type: ApplicationFiled: September 29, 2011Publication date: April 5, 2012Applicant: VOCO GmbHInventors: Tobias Blömker, Manfred Stepputtis, Manfred Thomas Plaumann, Reinhard Maletz, Nils Fontein
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Patent number: 8148488Abstract: Disclosed is a polyisocyanate composition which is excellent in both curability and drying characteristic. The polyisocyanate composition contains at least one compound selected from aliphatic diisocyanates, at least one compound selected from alicyclic diisocyanates and at least one compound selected from polyols, while satisfying all of the following conditions; i) the diisocyanate monomer concentration is not more than 3 mass %, ii) the polyol component concentration is 1-50 mass %; and iii) the glass transition temperature is from ?50° C. to 0° C.Type: GrantFiled: March 1, 2005Date of Patent: April 3, 2012Assignee: Asahi Kasei Chemicals CorporationInventors: Yoshiyuki Asahina, Masakazu Yamauchi, Hironori Katagawa
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Publication number: 20120058966Abstract: The invention relates to prodrugs of hydroxyl-substituted adamantane compounds, pharmaceutical compositions thereof, and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferative disease, inflammatory disease, or angiogenic disease.Type: ApplicationFiled: March 12, 2010Publication date: March 8, 2012Applicant: APOGEE BIOTECHNOLOGY CORPORATIONInventors: Charles D. Smith, Yan Zhuang, Lynn W. Maines
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Publication number: 20120046484Abstract: Disclosed are new compounds having utility in applications, including as reactants and intermediates in for the formation of polymers and polymeric materials especially useful as hydrogels for ophthalmic lenses.Type: ApplicationFiled: March 4, 2010Publication date: February 23, 2012Applicant: Cognis IP Management GmbHInventors: Ramesh Iyer, Peter McKenna, Mark Smallridge, Melissa Matthews, Anbu Natesh, Jody Baker
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Patent number: 8110704Abstract: Stable NCO prepolymers are produced from polyisocyanates having a melting point greater than 70° C., preferably, naphthalene diisocyanate, having advantageous physical properties. An important feature of the process of the present invention is the rapid cooling of the prepolymer. The process of the present invention may be carried out on a continuous or batch basis. The prepolymers of the present invention are particularly suitable for the production of cast polyurethane elastomers.Type: GrantFiled: November 2, 2006Date of Patent: February 7, 2012Assignees: Bayer MaterialScience LLC, Bayer MaterialScince AGInventors: James Michael Barnes, Hartmut Nefzger, Erika Bauer, Stefan Penninger, Thomas Schultz, Heinrich Lutz, Horst Di Mews, Charles S. Gracik
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Patent number: 8106141Abstract: Reaction products prepared from reactants including: (a) at least one compound of structural Formula (I): wherein R1 is selected from aryl and heteroaryl; X is selected from a direct bond, —O—, —S—, —NH—, alkylene, cycloalkylene, heterocyclylene, arylene, alkarylene, and heteroarylene; Y is a substituted alkylene group having at least two contiguous carbon atoms and which can be interrupted by one or more —O—, —S—, or —NH— moieties as defined herein, wherein the alkylene group of Y has substituents independently selected from —OH, —NH2, —SH, cycloalkyl, heterocyclyl, aryl, and heteroaryl, or two hydrogen atoms on the same carbon atom of Y are replaced by carbonyl, and wherein at least two substituents of Y are each independently selected from —OH, —NH2, and —SH, as defined herein; and (b) at least one isocyanate functional material.Type: GrantFiled: May 7, 2008Date of Patent: January 31, 2012Assignee: Henkel CorporationInventors: Anthony F. Jacobine, Andrew Messana, David M. Glaser, Steven Thomas Nakos
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Publication number: 20120022273Abstract: The present invention relates to a new process for the preparation of (poly)aminoalkylaminoacetamide derivatives of epipodophyllotoxin and salts thereof, characterised in that it comprises a step of peptide coupling of 4-amino-4?-demethylepipodophyllotoxin with an amine-containing reactant having protecting groups.Type: ApplicationFiled: September 23, 2008Publication date: January 26, 2012Applicant: PIERRE FABRE MEDICAMENTInventors: Yves Guminski, Martial Grousseaud, Thierry Imbert
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Publication number: 20120016050Abstract: Urethane acrylate oligomers, suitable for use in coatings and like formulations, prepared by capping polyols having hydroxyl functionality (fOH) equal to or greater than 4, using 2-isocyanatoethyl acrylate or 2-isocyanatoethyl methacrylate, thereby avoiding the gelation that normally occurs in attempting to prepare urethane acrylates with high/OH polyols by reaction with diisocyanates. Reaction of low molecular weight polyols, containing two or three hydroxyl groups, with mono isocyanate(meth)acrylate monomers produces useful, low viscosity urethane (meth)acrylate oligomers. Specifically, capping of a mole of 2,2-dihydroxymethyl butanoic acid by two moles of 2-isocyanatoethyl acrylate molecules leads to the formation of radiation curable water-soluble liquid monomers that are transparent and soluble in water. Oligomers obtained by capping with 2-isocyanatoethyl acrylate demonstrate enhanced adhesion to glass and stainless steel.Type: ApplicationFiled: December 24, 2009Publication date: January 19, 2012Inventors: Joseph A. Leon, Ahmet Nebioglu, James H. Aerykssen, Richard David Zopf, Igor V. Khudyakov
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Publication number: 20120010427Abstract: A method for producing urethane compounds includes allowing a primary amine, a urea and/or an N-unsubstituted carbamate, and an alcohol to react in the presence of a compound containing a noncoordinating anion and a metal atom as a catalyst.Type: ApplicationFiled: March 17, 2010Publication date: January 12, 2012Inventors: Tetsuya Hamada, Mitsuaki Chida, Souta Itou, Yoshiki Shimokawatoko, Koichi Murayama, Hiroshi Takeuchi
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Publication number: 20120000603Abstract: The invention relates to the use of special isocyanate-terminated polyurethane prepolymers in adhesive formulations. Said adhesive formulations can be used in applications wherein a direct or indirect contact of the adhesive layer takes place with substrates that are sensitive thereto.Type: ApplicationFiled: February 2, 2010Publication date: January 5, 2012Applicant: Bayer Materialscience AGInventors: Christos Karafilidis, Matthias Wintermantel, Heinz-Werner Lucas
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Patent number: 8063144Abstract: The present invention relates to polyacrylate-modified polyisocyanates which are i) prepared from aromatic, araliphatic, cycloaliphatic and/or aliphatic polyisocyanates having an NCO content of 5% to 25% by weight, an NCO functionality ?2 and a viscosity measured as solvent free resin of 150 to 200,000 mPa·s at 23° C., and ii) contain at least one structural unit of the formula (I) R is hydrogen or a methyl group, R1 is an optionally heteroatom-containing hydrocarbon radical and R2 is a hydrocarbon radical having at least one isocyanate group and optionally urethane, allophanate, biuret, uretdione, isocyanurate and/or iminooxadiazinedione groups and n is a number ?1; and to processes for preparing these polyisocyanates and to binder compositions containing these polyisocyanates, which may be hydrophilically modified and a compound having NCO-reactive groups.Type: GrantFiled: November 25, 2009Date of Patent: November 22, 2011Assignee: Bayer MaterialScience AGInventors: Christian Wamprecht, Martin Melchiors, Jörg Schmitz
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Publication number: 20110207086Abstract: Dental compositions and biphenyl di(meth)acrylate monomers are described. The dental compositions comprise at least one biphenyl di(meth)acrylate monomer comprising two aromatic rings connected with a C—C bond wherein the rings each comprise a substituent comprising a urethane moiety and a (meth)acrylate end group.Type: ApplicationFiled: October 19, 2009Publication date: August 25, 2011Inventors: Jie Yang, Naimul Karim, David B. Olson, Todd D. Jones, Dwight W. Jacobs
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Publication number: 20110207893Abstract: The invention relates to surface modifying macromolecules (SMMs) having high degradation temperatures and their use in the manufacture of articles made from base polymers which require high temperature processing. The surface modifier is admixed with the base polymer to impart alcohol and water repellency properties.Type: ApplicationFiled: August 28, 2009Publication date: August 25, 2011Applicant: INTERFACE BIOLOGIS INC.Inventors: Sanjoy Mullick, Weilun Chang, Alexandra Piotrowicz, Jeannette Ho, Richard Witmeyer
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Patent number: 7994354Abstract: Methods to convert biobased oils, oil derivatives, and modified oils to highly functionalized esters, ester polyols, amides, and amide polyols. The products can be used to make polyurethane and polyester films and foams.Type: GrantFiled: April 26, 2006Date of Patent: August 9, 2011Assignee: Battelle Memorial InstituteInventors: Herman Paul Benecke, Daniel B. Garbark, Bhima Rao Vijayendran
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Publication number: 20110144376Abstract: An object of the present invention is to provide dermatological agents such as whitening agents and hair growth accelerators that contain a compound having high water solubility and a specific structure capable of releasing 2,3-dimethoxy-5-methyl-1,4-dihydroxybenzene (reduced form). A dermatological agent according to the present invention contains a 2,3-dimethoxy-5-methyl-1,4-dihydroxybenzenecarboxylic acid ester derivative represented by the following general Formula (I) or a salt thereof: wherein in the Formula (I), R1, R2 and R3 are specific groups.Type: ApplicationFiled: August 20, 2008Publication date: June 16, 2011Applicant: SHOWA DENKO K.K.Inventors: Jiro Takata, Nami Akaho, Kazuhisa Matsunaga, Yoshiharu Karube, Manabu Nakashima
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Publication number: 20110144170Abstract: The present invention provides compounds capable of binding to an Fc receptor and modulating Fc receptor activity comprising a core lipophilic group in the form of an Aryl zing substituted with a group rich in p-electrons. The invention further provides for a method of treating an autoimmune disease involving Fc receptor activity using such compounds. A method for obtaining a compound which modulates Fc receptor activity is also provided, the method comprising: (a) providing or designing compounds having structural characteristics to fit in the groove of the Fc?RIIa structure; and (b) screening the compounds for modulating activity on the Fc receptor.Type: ApplicationFiled: February 18, 2011Publication date: June 16, 2011Inventors: Mark Phillip Hogarth, Geoffrey Allan Pietersz, Gerard Peter Moloney
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Publication number: 20110118501Abstract: Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.Type: ApplicationFiled: January 13, 2011Publication date: May 19, 2011Applicant: Ambrx, Inc.Inventors: Zhenwei Miao, Junjie Liu, Thea Norman, Russell Driver
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Publication number: 20110091728Abstract: A synthesis and purification of felbamate, an anticonvulsant, are provided. The product of the synthesis and purification is with high untapped and tapped bulk densities, which increase ease of handling and suitability for use in pharmaceutical formulations. The felbamate may be incorporated into pharmaceutical compositions that can be administered orally for treatment of epilepsy.Type: ApplicationFiled: December 28, 2010Publication date: April 21, 2011Inventors: Christopher Newton Jobdevairakkam, Hero Velladurai
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Publication number: 20110087040Abstract: A bromine/nitro moiety linked into the backbone of an ester or other compound over a wide range of occurrence rates provides antimicrobial, bio-resistant and fungal resistant properties for metal working fluids (MWF)s and other coatings. The moiety can be have the bromo and nitro groups linked to the same or different carbon atoms. The present invention also relates to urethanes, urea, amides, imides, carbonates, ethers, siloxanes, and many other types of linkages essential to MWF bases.Type: ApplicationFiled: December 10, 2010Publication date: April 14, 2011Inventor: Thomas Daly
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Patent number: 7923574Abstract: The invention relates to novel prepolymers which are accessible from the formamides of oligomeric di- or polyamines (formamide-terminated oligomers) and di- or polyisocyanates.Type: GrantFiled: February 23, 2009Date of Patent: April 12, 2011Assignee: Bayer MaterialScience AGInventors: Marc Leimenstoll, Burkhard Köhler, Christos Karafilidis, Matthias Wintermantel
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Publication number: 20110073977Abstract: There is provided an amino acid generator comprising a protecting group for an amino group that is eliminated to generate an amino acid, and a coating film forming composition using the amino acid generator and a polysiloxane composition containing the amino acid generator. A coating film forming composition comprising: a component (A): an amino acid generator comprising a protecting group that is eliminated to generate an amino acid, which is a compound of Formula (1): D-A (1) where D is a protecting group for an amino group, and A is an organic group remaining after subtracting hydrogen atoms from an amino group of an amino acid; a component (B): a hydrolyzable silane, a hydrolysis product thereof, a hydrolysis-condensation product thereof, or a mixture thereof; and a component (C): a solvent.Type: ApplicationFiled: May 19, 2009Publication date: March 31, 2011Applicant: NISSAN CHEMICAL INDUSTRIES, LTD.Inventors: Taku Kato, Junpei Kobayashi, Satoko Takano, Naoki Sakumoto
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Publication number: 20110076491Abstract: There is disclosed a curable PSA made by a solventless single stage polymerisation of the following materials: from about 10% to about 80% by weight of at least one polyol which has molecular weight at least 1000 daltons; from about 0.5% to about 20% at least one poly-isocyanate(s) from about 0.1% to about 10%, by weight of at least one hydroxyl (meth)acrylate(s); from about 10% to about 80% by weight of one or more tackifier resins.Type: ApplicationFiled: December 6, 2010Publication date: March 31, 2011Inventors: Victor Lu, Jeffrey Wang
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Patent number: 7897718Abstract: The present invention relates to an acrylated semi-crystalline hyperbranched polyurethane oligomer and a preparation method thereof, which is characterized in that on the basis of the synthesis of hyperbranched polyurethane oligomer, it adopts a two-step process to make modifications to form a methacrylic and/or acrylic double bond and a long carbon chain with a carbon atom number higher than 10 or a benzene ring or a naphthalene ring at the terminals. The obtained oligomer has a lower melting point and a higher glass transition temperature and can be cured by means of radiation, and the curing rate is high enough to effectively improve production efficiency and save energy to form a cured film having a higher hardness and excellent thermal stability. The raw materials used in the method of the invention are easily obtained, and the method is suitable for large-scale production in industry.Type: GrantFiled: May 18, 2006Date of Patent: March 1, 2011Assignee: Eternal Chemical Co., Ltd.Inventors: Chi-Kang Chang, Chin-Yuan Chen, Wen-Fang Shi, Hong-Bo Liang
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Patent number: 7893184Abstract: Dendritic or hyperbranched polyurethanes are prepared by 1) reacting diols or polyols having at least one tertiary nitrogen atom and at least two hydroxyl groups of differing reactivity toward isocyanate groups with diisocyanates or polyisocyanates to form an addition product, with the diols or polyols and diisocyanates or polyisocyanates being selected so that the addition product has, on average, one isocyanate group and more than one hydroxyl group or one hydroxyl group and more than one isocyanate group, 2) converting the addition product from step 1) into a polyaddition product by intermolecular reaction of the hydroxyl groups with the isocyanate groups, and with a reaction with a compound containing at least two hydroxyl groups, mercapto groups, amino groups or isocyanate groups also being able to be carried out first, 3) if desired reacting the polyaddition product from step 2) with a compound containing at least two hydroxyl groups, mercapto groups, amino groups or isocyanate groups.Type: GrantFiled: May 14, 2004Date of Patent: February 22, 2011Assignee: BASF AktiengesellschaftInventors: Bernd Bruchmann, Jean-Francois Stumbe
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Publication number: 20110040043Abstract: Disclosed is a diurethane compound R2(SO2)m(CH2)nOCONH—R1—NHCOO(CH2)n(SO2)mR2 produced by a method allowing a diamine compound H2NR1NH2 to react with a chloroformate compound ClCOO(CH2)n(SO2)mR2 or a method allowing a diisocyanate compound OCNR1NCO to react with a hydroxyl-containing compound R2(SO2)m(CH2)nOH. The diurethane compound is compounded with multivalent amine crosslinkable group-containing acrylic rubber together with a basic vulcanization accelerator to form an acrylic rubber composition. The acrylic rubber composition including the diurethane compound as a vulcanizing agent decreases a delay in the vulcanization rate due to prevention of scorching and also allows a vulcanized article to satisfy the compression set characteristics.Type: ApplicationFiled: January 30, 2009Publication date: February 17, 2011Applicant: Unimatec Co., Ltd.Inventors: Daisuke Ito, Haruyoshi Tatsu, Keisuke Kokin, Hideyuki Ono, Yasuhiro Onoue
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Patent number: 7884227Abstract: A synthesis and purification of felbamate, an anticonvulsant, are provided. The product of the synthesis and purification is with high untapped and tapped bulk densities, which increase ease of handling and suitability for use in pharmaceutical formulations. The felbamate may be incorporated into pharmaceutical compositions that can be administered orally for treatment of epilepsy.Type: GrantFiled: October 27, 2008Date of Patent: February 8, 2011Assignee: Navinta LLCInventors: Christopher Newton Jobdevairakkam, Hero Velladurai
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Publication number: 20110028701Abstract: Provided is an industrially safe and useful azodicarboxylic acid bis(2-alkoxyethyl) ester compound that is useful for the Mitsunobu reaction in which it is used in combination with a phosphorus compound to carry out a dehydration condensation reaction, and also useful as an oxidizing agent, and a starting material for various synthetic processes. Also provided are a production intermediate of the above-described compound, and methods for producing these compounds. An azodicarboxylic acid bis(2-alkoxyethyl) ester compound represented by formula (1); wherein A represents an alkyl group having 1 to 10 carbon atoms.Type: ApplicationFiled: September 27, 2010Publication date: February 3, 2011Inventors: Kazutake HAGIYA, Takashi SUGIMURA
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Publication number: 20110021761Abstract: Segmented water soluble polymers, containing a higher molecular weight segment linked to a lower molecular weight segment, are described. In one embodiment, the polymer segments are poly(ethylene glycol) segments. The segmented polymers are functionalized and are useful for conjugation to various moieties such as pharmacologically active substances. Also described are conjugates of such polymers and methods of their preparation.Type: ApplicationFiled: October 5, 2010Publication date: January 27, 2011Applicant: Nektar TherapeuticsInventors: Antoni Kozlowski, Xiaoming Shen, Michael D. Bentley, Zhihao Fang, Tony L. Sander