Abstract: A process for preparing polyisocyanate prepolymers containing allophanate structural units that includes reacting a) one or more polyisocyanates with b) one or more polyetherpolyols containing less than or equal to 0.02 milliequivalent of unsaturated end groups per gram of polyol and having a polydispersity of from 1.0 to 1.5 and/or an OH functionality of greater than or equal to 1.9 ?to provide an NCO-functional polyurethane prepolymer containing urethane groups that are partly or fully allophanatized by further reaction with c) polyisocyanates, which may be different from those from a), and d) catalysts and optionally adding e) acidic additives before, during and/or after the allophanatization. The polyisocyanate prepolymers can be used to produce coatings, adhesive bonds and/or seals. The coatings include one or more of the polyisocyanate prepolymers, and at least one diol or polyol and/or at least one linear and/or cyclic, aliphatic, araliphatic and/or aromatic diamine or polyamine.

Abstract: A blocked polyisocyanate adduct including 5 to 95% by weight of at least one isocyanate component having at least one NCO group, the isocyanate component selected from the group consisting of aliphatic, cycloaliphatic and aromatic isocyanates, wherein the isocyanate has an average molecular weight of up to 1000 g/mol and an average NCO functionality of 2–4; 5 to 70% by weight of at least one hydrophilicizing component containing at least one group which is reactive toward the at least one NCO group; at least one blocking agent for blocking from 95 to 100% of the NCO groups which do not react with the hydrophilicizing component; and up to 15% by weight of at least one neutralizing agent.

Abstract: Disclosed are colorant precursor compounds of the formula wherein R is an alkyl group, an aryl group, an arylalkyl group, or an alkylaryl group, and wherein R can be joined to the phenyl moiety to form a ring, each R?, independently of the others, is a halogen atom, an alkyl group, an alkoxy group, a nitrile group, a nitro group, an amide group, or a sulfonamide group, z is an integer of 0, 1, 2, 3, or 4, n is an integer representing the number of carbon atoms in each repeat alkylene oxide unit, and x is an integer representing the number of repeat alkylene oxide units, wherein said colorant precursor has no more than one —OH, —SH, or primary or secondary amino group per molecule.

Abstract: Provided is a compound having one or more structures of the formula: wherein X is a primary carbamate group, Y is a hydroxy or halide group, n is an integer of 2 or more, n? is an integer of 1 or more, and R0, R1, R2, R3, R4 and R5 may be H or a group selected from alkyl groups, aliphatic groups, cycloaliphatic groups, aromatic groups and mixtures thereof, with the provisos that at least one R1 or R2 group is selected from the group consisting of aliphatic groups, cycloaliphatic groups, and aromatic groups, and in substantially all structures primary carbamate group X is attached to a carbon atom having a lower degree of substitution than a carbon atom to which functional group Y is attached. The invention provides a method of making the claimed compound.

Abstract: Compounds of formula (I) in which M, B1, B2, B3, B4, B5, B6, A1, A2, A3, A4, A5, A6, K1 and K2 have the meanings as indicated in the description, are novel effective tryptase inhibitors.

Abstract: Valency platform molecules comprising high molecular weight polyethylene oxide groups are provided, as well as conjugates thereof with biologically active molecules, and methods for their preparation. The high molecular weight polyethylene oxide group has, for example, a molecular weight of greater than 22,000 Daltons, for example at least 40,000 Daltons. In one embodiment, a composition comprising the valency platform molecules is provided, wherein the molecules have a polydispersity less than about 1.2. Conjugates of the valency platform molecule and a biologically active molecule, such as a saccharide, poly(saccharide), amino acid, poly(amino acid), nucleic acid or lipid also are provided. Also provided are pharmaceutically acceptable compositions comprising the conjugates disclosed herein and a pharmaceutically acceptable carrier, as well as methods of making and using the conjugates and compositions.

Abstract: Polyaspartate derivatives, especially hydrophobically modified and/or hydrophilically modified polyaspartate derivatives, most especially polyaspartate derivatives that are both hydrophilically and hydrophobically modified, for use in detergent compositions, specifically laundry detergent compositions for providing cleaning, dispersancy, especially soil dispersion, builder properties and/or improved whitening of fabrics contacted by such detergent compositions; and methods for making such polyaspartate derivatives, and methods and articles employing such detergent compositions, are provided.

Abstract: A prepolymer is prepared by reacting a mixture containing (a) at least one multifunctional compound, (b) at least one diisocyanate, and (c) at least one diol. The diol has a weight average molecular weight of at most 6000. The prepolymer, when reacted with an excess of water, forms a hydrogel polymer. The mixture of the prepolymer and water may be reaction molded, and used to form a contact lens.

Abstract: Derivatives of bis-(1,3-dihydroxy-prop-2-yl)amine are disclosed, together with the use of such derivatives and of bis(1,3-dihydroxy-prop-2-yl)amine itself in the preparation of polymers, in particular dendrimers. Some of the derivatives may be useful as non-ionic surfactants.

Abstract: Pleuromutilin compounds of the formula: are of use in anti-bacterial therapy.

Abstract: Catalysts contain, as structural units, at least one tertiary amino group and at least one group which, after its decomposition, is capable of complexing or protonating the tertiary amino group.

Abstract: Using at least one compound selected from the group consisting of a zirconyl compound and a zirconium alcoholate as an allophanation catalyst, an allophanate group-containing polyisocyanate composition is produced from a starting material of at least one isocyanate compound selected from the group consisting of an aliphatic diisocyanate, an alicyclic diisocyanate and an isocyanate pre-polymer obtained therefrom, and another starting material of a hydroxyl group-containing compound.

Abstract: One aspect of the present invention relates to base-labile, carbamate-containing crosslinkers. A second aspect of the present invention relates to degradable crosslinked polymers and hydrogels comprising a base-labile, carbamate-containing crosslinker. The present invention also relates to methods of preparing base-labile, carbamate-containing crosslinkers. Another aspect of the present invention relates to methods of preparing cross-linked polymers and hydrogels comprising a base-labile, carbamate-containing crosslinker.

Abstract: Amine-terminated urethane oligomer compositions are described that include very high oligomer concentrations. The compositions are melts of the amine-terminated oligomers. The compositions can include one or more property modifiers. The compositions are useful in the formation of crosslinked copolymers, especially with epoxy resins. The resulting copolymers are useful in the formation of coatings.

Abstract: Polyurethanes or polyurethane-ureas prepared from: (a) polytrimethylene ether glycol having a number average molecular weight in the range of about 1,000 to about 4,000 and unsaturated end groups in the range of about 0.003 to about 0.015 meq/g; (b) diisocyanate; and (c) diol or diamine chain extender; and their manufacture, intermediates and use.

Abstract: The present invention relates to solvent-free, NCO prepolymers having a residual IPDI monomer content of less than 2.0 wt. %, an NCO content of 2.0 to 5.0 wt. % and a viscosity of 5000 to 20,000 mPa·s, wherein the NCO prepolymers are the reaction products of i) 3-isocyanatomethyl-3,5,5-trimethylcyclohexyl isocyanate and ii) one or more polyethers prepared by the DMC catalyst process and having an OH-functionality of 1.80 to 2.00 at an NCO/OH equivalent ratio of 1.5:1 to 2.2:1. The present invention also relates to a process for preparing these solvent-free, NCO prepolymers and to polyurethane coating, sealant, adhesive and/or embedding compositions containing the solvent-free, NCO prepolymers as a binder and/or binder component.

Abstract: Fluorochemical urethane compositions comprising one or more compounds or oligomers having at least on fluorine-containing repeatable unit and at least one fluorine-containing terminal group are described. The compositions are useful as coatings or incorporated as melt additives. The fluorochemical compositions impart oil and water repellency to the substrate. In other aspects, this invention relates to processes for imparting oil and water repellency characteristics to substrates and articles.

Abstract: The present invention relates to a composition and use of polymeric urethane ester quats as an active ingredient for skin and hair contacting personal care compositions and products related thereto. These compositions are generally produced by the reaction of a trialkanolamine with a hydroxy fatty acid to produce a trialkanolamine fatty acid ester, which is then polymerized with a diisocyanate and in preferred embodiments, further reacted with a quaternizing agent, to produce preferred quaternized compositions according to the present invention.

Abstract: Heterobifunctional polymeric prodrug platforms for delivering biologically active compounds, including proteins, monoclonal antibodies and the like are disclosed.

Abstract: The invention is directed to a novel biomedical polyurethane based on diisocyanatae linked polyester polymer and diol components, said diol component having a uniform block-length.

Abstract: Disclosed is a polyether polyurethane comprising (A) at least one polyisocyanate having two or more isocyanate groups, which is selected from the group consisting of an aromatic polyisocyanate and an aliphatic polyisocyanate; (B) a polyoxytetramethylene glycol (PTMG) having a number average molecular weight of from 500 to 4,000, a molecular weight distribution (Mw/Mn) of 1.75 or less, and a content of high molecular weight PTMG molecules of 10% by weight or less; and (C) at least one chain extender selected from the group consisting of a C2-C10 polyol having two or more hydroxyl groups and a C2-C10 polyamine having two or more amino groups. Also disclosed is a urethane prepolymer which comprises the above-mentioned components (A) and (B) and which has terminal isocyanate groups.

Abstract: The present invention relates to a film forming composition, a method of forming the composition, and application of the composition to coating formulations which provide a cured coating having acid rain resistance. A film-forming polyurethane polyol composition comprises a reaction product of an n-functional isocyanate (wherein n is a number ranging from about 2 to about 5) with at least one diol or triol or mixtures thereof and a compound containing isocyanate-reactive functional groups, preferably a monofunctional alcohol or thiol. The low viscosity polyurethane polyol of the present invention is typically crosslinked/cured using a melamine to produce a cured coating which is highly acid etch resistant as well as having other desirable physical-mechanical properties. The coating compositions have improved flow characteristics compared to compositions containing polyurethane polyols prepared without the monofunctional alcohols or thiols.

Abstract: Lubricating agent containing fluorinated urethanes Lubricants comprising fluorinated urethanes, prepared by reacting

Abstract: A self-emulsifiable polyisocyanate with high functionality, having the average number of functional groups in 4.3 or more and a viscosity of 8,000 mPa·s (at 25° C.) or less, which is obtained by subjecting a modified polyisocyanate containing allophanate bonds and a poly(oxyalkylene)glycol monoalkyl ether (e) having oxyethylene bonds in a total amount of 30 mole % or more in its molecule to a urethanization reaction, said modified polyisocyanate being obtained by reacting a polyol (a) having the average number of functional groups in an amount of 2 or more with an organic polyisocyanate (b) in the presence of an allophanate-forming catalyst (c) comprising a zirconium carboxylate; and a process for producing the same.

Abstract: Provided is a compound having one or more structures of the formula: 1

Abstract: A method for preparing a polyol useful in the formation of an isocyanate casting resin or coating composition is presented involving the reaction of an essentially C18 fatty acid mixture with a monofunctional alcohol to form a fatty acid ester mixture, forming a epoxidized fatty acid ester mixture from the fatty acid ester mixture, and reacting the epoxidized mixture with an aliphatic alcohol to form a polyol. The polyol can be further reacted with an isocyanate to form a casting resin or coating composition. The fatty acid mixture contains at least 80 percent oleic acid. Polyols prepared by this method provide good color quality and improved color stability during storage when used in the production of isocyanate casting resins and coating compositions.

Abstract: Phase change ink carrier compositions comprising an admixture of (1) at least one urethane resin; and/or (2) at least one mixed urethane/urea resin; and/or (3) at least one mono-amide; and/or (4) at least one polyethylene wax are provided. In addition, a phase change colored ink of such carrier compositions comprising a phase change ink compatible colorant are also provided. Embodiments of the present invention also include methods for producing a layer of the above phase change colored ink on the surface of a substrate by either direct or indirect printing. Such methods also encompassing using a polyethylene wax as an overcoat layer above such a phase change ink layer on a printed substrate.

Abstract: The present invention is directed to new compositions of matter comprising the reaction products of a carboxylic acid and a urea having the formula: where R1, R2, R3 and R4 are the same or different and are selected from the group consisting of hydrogen, substituted and unsubstituted alkyl, allyl, vinyl and alkoxyl groups having from 1-6 carbon atoms, substituted and unsubstituted phenyl groups and the halides. Preferably, the reaction product of the present invention is N,N′-diformylurea or N,N′-diacetylurea. These reaction products, e.g., diformylurea, have been found to produce significantly improved growth in a variety of agricultural products when applied to the seed, to the surrounding soil or to the foliage of the emerging plant. Because of the similarity in the carbon, nitrogen, oxygen structure of these reaction products with many biological compounds, it is believed that the reaction products of the present invention may find use in a variety of biological applications.

Abstract: The invention relates to polycarbamates of the formula I in which R and R′ are identical or different and are alkyl groups having 1-4 carbon atoms and n is a number from, on average, 2 to 5.

Abstract: The end-blocked isocyanate prepolymer having an oxadiazine ring according to the present invention is characterized in that at least one of isocyanate groups of a NCO-terminated isocyanate prepolymer, which has NCO groups at the ends and comprises units derived from an oxadiazinetrione compound (A) represented by the following formula (1) and units derived from an active hydrogen compound (B) represented by the following formula (2), is blocked with a unit derived from an end-blocking agent (C) having at least one active hydrogen in one molecule, and that the end-blocked isocyanate prepolymer has a softening point of not lower than 50° C.

Abstract: A method of forming polymers in the presence of nucleic acid using template polymerization. Also, a method of having the polymerization occur in heterophase systems. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes containing nucleic acid and polymer, and for forming an interpolyelectrolyte complex.

Abstract: The invention provides gamma hydroxy primary carbamate functional compounds, film-forming compositions comprising such compounds and methods of making the same.

Abstract: The invention relates to a compound comprising a reaction product of (A) an isocyanate functional compound of which at least 40 wt. %, relative to the total amount of (A), has a molecular weight of at least about 500, and (B) a nitrogen-containing compound capable of reacting with said isocyanate functional compound (A). The reaction product has a molecular weight of less then about 20,000 and comprises an effective amount of groups that are able to form reversible intermolecular physical interactions such that a resulting compound shows polymeric mechanical properties at a temperature below a transition temperature. The nitrogen-containing compound is, for instance, melamine, urea, acetoguanamine, benzoguanamine, cyanamide, dicyanamide, thiourea, isocytosine, pyrimidone or aminopyridine. The supramolecular compound comprising a suitable amount of the reaction products exhibits a relatively high elongation at break.

Abstract: A method of preparing a 2-alkyl amino acid involves the aziridination of an alkylacrylate and the opening of the aziridine ring by addition of a side chain. This method can result in the preparation of enantiomeric excess of a 2-alkyl amino acid. The invention also discloses a method of preparing a class of iron chelating agents related to desferrithiocin, all of which contain a thiazoline ring. In this method, an aryl nitrile or imidate is condensed with cysteine, a 2-alkyl cysteine, or a cysteine ester.

Abstract: Acrylate, or methacrylate, or allylic, functionalized polyfluorooxetanes are disclosed for use in radiation curable coating compositions. These acrylate, or methacrylate, or allylic, functionalized polymers provide improvements in wetting and surface properties that have previously been provided by migratory chemicals such as waxes and oils. The partially or fully fluorinated side groups of the fluorooxetanes are believed to be disproportionately present at the interfaces between the coating and the substrate and between the coating and the atmosphere.

Abstract: The invention relates to a process for synthesizing tertiary phosphines by reacting halophosphines with organomagnesium compounds in the presence of copper compounds and optionally of salts.

Abstract: Hydroxy functional urethane compounds comprising the reaction product of a hydroxy functional urethane intermediate with a compound having at least 2 isocyanate groups, wherein the intermediate is represented by the formula: wherein R1 and R2=hydrogen, alkyl, cycloalkyl or a residue R6—O— or R6—CO—O— with R6; R6=an alkyl, cycloalkyl or benzylic group having up to 18 carbon atoms; R4 and R5=hydrogen or alkyl group containing eventually a hydroxyl group; and R3=alkyl, cycloalkyl or benzylic group eventually containing an ether linkage and/or a hydroxyl group, or HO—CH(R1)—CH(R2)—; and is prepared by reaction of a cyclic 5-ring carbonate with a beta-hydroxy functional, secondary amine. The hydroxy functional urethanes are useful in paints and coatings, particularly for automotive applications.

Abstract: Novel addition products of hydroxyl-protecting groups (such as isocyanates) with oxyalkylene-substituted intermediates, such as poly(oxyalkylenated) aniline compounds, for the eventual production of substituted, and substantially pure, colorants, particularly diazo and triphenylmethane derivatives, through the reaction of such intermediates with certain reactants are provided. These new colorants exhibit improved wax and/or oil solubility and high purity, particularly due to the inability of certain impurities to deleteriously react with the protected hydroxyl groups of either the intermediate or the colorant during and/or after formation thereof. A method for producing such novel colorants through utilization of these novel substantially pure colorant intermediates is also provided.

Abstract: Water-in-Oil emulsions are demulsified using adducts of a) polyalkylene glycols (PAGS) having a molecular weight greater than 6,500 and up to 60,000, ethylene oxide (EO), and diisocyanates (DIs) or b) polyalkylene glycols (PAGs) having a molecular weight greater than 6,500 and up to 60,000 and diisocyanates (DIs). The preferred PAG is polypropylene glycol and the preferred DIs are meta or para tetramethylxylene diisocyanate and toluene diisocyanate.

Abstract: Oligomeric and high molecular mass products of reaction of alkyl and aryl allophanates with nucleophilic compounds, and also low molecular mass, oligomeric and high molecular mass compounds containing lateral and/or terminal allophanate groups, and also the use of the reaction products and/or of the compounds in coating compositions, adhesives and sealing compounds or for producing films.

Abstract: The present invention relates to polyurethane polyol compositions comprising the reaction product of a polyisocyanate, a polyol, and a Guerbet alcohol having at least 12 carbon atoms or a Guerbet alcohol mixture having an average of at least 12 carbon atoms. Preferred polyols are &agr;,&bgr; diols and &agr;,&ggr; diols. The polyurethane polyol compositions exhibit very low viscosity and are particularly useful in very low VOC coating compositions. The resulting cured coating provides surprisingly improved properties.

Abstract: The invention relates to polycarbamates of the formula I 1

Abstract: Resins and waxes made by reacting selected nucleophiles, including alcohols and/or amines, with an isocyanate are disclosed. The order of addition of the isocyanate and the different nucleophiles can tailor the distribution of di-urethane, mixed urethane/urea, and/or di-urea molecules in the final resin product. The isocyanate-derived resin and wax materials are useful as ingredients as phase change ink carrier compositions used to make phase change ink jet inks.

Abstract: The present invention is directed to monomeric and polymeric compositions based upon polymeric urethane surfactants which are derived from linear, branched, or aromatic compounds of synthetic or natural origin, preferably from tertiary amines and diisocyanate compounds. The urethane polymers of the present invention may be in the form of betaines, quaternium salts, tertiary amine salts or N-oxides. The compounds of the present invention may be incorporated into personal care formulations such as cosmetics, dental care products and toiletries to improve at least one and preferably two or more characteristics of such formulations.

Abstract: A process is described which imparts exceptional antisoiling, anti-staining and repellent properties to carpets. The process makes use of a water-based exhaustion process wherein the water-based treating solution contains (1) glassy fluorochemical material, glassy hydrocarbon material, or combinations thereof; (2) a stainblocking material; (3) a polyvalent metal salt, acid, or combinations thereof; and (4) water. Subsequent to exhaustion, the wet treated carpet is heated, usually in a steaming step, rinsed, and dried in a dry heat oven.

Abstract: A method for preparing organic products from aqueous solutions, such as waste or byproduct liquid streams and waste or byproduct gas or vapor streams, uses phase transfer catalysis to transfer a chemical species in low concentration from the aqueous solution to the organic phase or the aqueous-organic interface. The system has little or no organic solvent, and the organic phase contains an electrophile which participates in the reaction. In one embodiment, the aqueous solution is contacted with the electrophile and a phase transfer catalyst and, optionally, a pH adjusting agent in the event that the chemical species in the aqueous solution is not sufficiently ionized to react with the electrophile, and optionally an organic solvent. A method for continuously converting a chemical species involves this contacting step, separating the phases, then dividing the organic phase into the product, the phase transfer catalyst, and the optional organic solvent.

Abstract: The invention concerns the use of a polyamine derivative or a polyamine for inhibiting the active site of glycosidase enzymes intervening in the transformation of polysaccharides into sugars, in particular into glucose, in a living organism.

Abstract: The invention is directed to polyurethane foam shoe soles containing an additive comprising a mixture of polyethylene wax and PTFE (polytetrafluoroethylene), and to polyol components containing the additive. The additive is produced to include the mixture at a density from greater than 0.97 to about 1.1 times the density of the polyol component.

Abstract: The present invention provides improved ingress of therapeutic and other moieties into cellular targets. In accordance with preferred embodiments, complexes are provided which carry primary moieties, chiefly therapeutic moieties, to such target cells. Such complexes preferably feature cell surface receptor ligands to provide specificity. Such ligands are preferably bound to primary moieties through polyfunctional manifold compounds.

Abstract: A method for producing carbamates that enables carbamates to be produced at low costs, with high selectivity and high yield, and in a simple manner, and a method for producing isocyanates that enables isocyanates industrially used to be produced by using the carbamates obtained by the carbamates producing method. Nonaromatic amine selected from the group consisting of aliphatic amine, alicyclic amine, and aralkyl amine is allowed to react with alkylaryl carbonate to thereby produce carbamates. Also, the carbamates thus obtained are thermally decomposed to thereby produce isocyanates. When carbamates are produced in this method, alkyl carbamates can be obtained with high selectivity and at high yield by using simple equipment. Also, when isocyanates are produced in this method, polyisocyanates used industrially as the raw material of polyurethane can be produced in a simple manner and with efficiency.