Oxy, Not Bonded Directly To A Ring, In Same Side Chain As Ester Function Patents (Class 560/60)
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Publication number: 20080214587Abstract: The present invention relates, inter alia, to a process for preparing a compound of formula (I): which comprises either (a) reacting a compound of formula (II): with 2-cyanophenyl, or a salt thereof, in the presence of between 0.1 and 2 mol % of 1,4-diazabicyclo[2.2.2]octane, or (b) reacting a compound of the formula (III): with a compound of the formula (IV): in the presence of between 0.1 and 2 mol % of 1,4-diazabicyclo[2.2.2]octane; where W is the methyl (E)-2-(3-methoxy)acrylate group C(CO2CH3)?CHOCH3 or the methyl 2-(3,3-dimethoxy)propanoate group C(CO2CH3)CH(OCH3)2, or a mixture of the two groups. In addition, the present invention relates to a novel precursors of the compound of formula (I) and methods for making them.Type: ApplicationFiled: April 13, 2006Publication date: September 4, 2008Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Alan John Whitton, Ewan Campbell Boyd, Jack Vass
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Publication number: 20080194825Abstract: The present invention refers to a process for the synthesis of (1-{1-(R)-(E)-{3-[2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-3-[2-(1-hydroxy-1-methyl-ethyl)-phenyl]-propylsulfanylmethyl}-cyclopropyl)-acetic acid or its salts, comprising the reaction between 7-Chloro-2-vinyl-quinoline and a compound of formula (I) wherein X is a halogen atom or a group of formula —OSO2R, wherein R is selected from the group consisting of CF3, tolyl, methyl and F; in the presence of a palladium based catalyst. The invention is also directed to intermediates compounds of the process.Type: ApplicationFiled: April 18, 2007Publication date: August 14, 2008Applicant: INKE, S.A.Inventors: Juan Antonio Perez Andres, Juan Huguet Clotet, Pere Dalmases Barjoan
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Publication number: 20080182897Abstract: This invention is directed to the crystalline potassium salt of a lipoxin A4 analog of Formula (I): processes for preparing the crystalline potassium salts, methods for using them to treat disease-states characterized by inflammation, and pharmaceutical compositions comprising such crystalline potassium salts.Type: ApplicationFiled: December 3, 2007Publication date: July 31, 2008Applicant: Bayer Schering Pharma AktiengesellschaftInventors: Tilo Haag, Danja Grossbach, Gabriele Winter, Michael Sander, Wolfgang Beckmann, Klaus Bartel, Christian Dinter
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Publication number: 20080153905Abstract: Esters of 2-phenylalkanenitriles, such as 3-acetoxy-2-(2-chloro-5-(difluoromethoxy)phenyl)propanenitrile and 3-acetoxy-2-(4-chlorophenyl)propanenitrile, and compositions containing such esters, are useful as fungicides at very low concentrations.Type: ApplicationFiled: December 20, 2006Publication date: June 26, 2008Inventor: Donald Wesley Stoutamire
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Patent number: 7371888Abstract: Compounds having a formula: or a pharmaceutically acceptable salt or prodrug thereof, are provided, and are useful for the treatment of metabolic disorders.Type: GrantFiled: February 17, 2005Date of Patent: May 13, 2008Assignee: Metabolex, Inc.Inventors: Zuchun Zhao, Xin Chen, Jianchao Wang, Hongbin Sun, Jack Shih-Chieh Liang
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Patent number: 7368566Abstract: Disclosed is a new process and intermediates for preparing benzazepines of Formula (I): wherein R1 and R2 are as defined herein.Type: GrantFiled: March 29, 2004Date of Patent: May 6, 2008Assignee: SmithKline Beecham CorporationInventors: Jose J. Conde, Lewilynn L. Goldfinger, Michael A. McGuire, Susan C. Shilcrat, Michael D. Wallace, Marvin Sungwhan Yu
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Patent number: 7355063Abstract: The compound represented by the following formula (1): wherein A, B, R1, R2, R3 and Z are as defined in the specification is analogous to shogaol and gingerol useful in the fields of foods, medicines, quasi-drugs, cosmetics, etc., and more highly active in tyrosinase activity inhibition, etc. than shogaol and gingerol.Type: GrantFiled: March 26, 2004Date of Patent: April 8, 2008Assignee: Toagosei Co., Ltd.Inventors: Shuhei Yamaguchi, Hisatoyo Kato
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Patent number: 7351850Abstract: A process by which an ?-oxocarbonyl compound useful as an intermediate for pharmaceuticals/agricultural chemicals can be industrially advantageously and efficiently produced in a high yield. The process, which is for producing an ?-oxocarbonyl compound represented by the general formula (I) wherein R1 and R2 are as defined in the description, comprises oxidizing an ?-hydroxycarbonyl compound represented by the general formula (II) with oxygen or air in the presence of a carboxylic acid and at least one vanadium compound selected from divanadium pentaoxide, divanadium trioxide, divanadium tetraoxide, ammonium metavanadate, sodium metavanadate, potassium metavanadate, triethoxyoxovanadium, tripropoxyoxovanadium, triisopropoxyoxovanadium, vanadium oxobis(acetylacetonate) and vanadium tris(acetylacetonate).Type: GrantFiled: May 18, 2005Date of Patent: April 1, 2008Assignee: Kuraray Co., Ltd.Inventors: Fumihiko Okabe, Hideki Matsuda, Takashi Yamaguchi
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Patent number: 7153969Abstract: Methyl (R)-2-(R1OSO2)-2-(2-chlorophenyl)acetates useful as intermediates in the preparation of methyl (S)-2(2-chlorophenyl)-2-(4,5,6,7-tetrahydrothieno[3,2-c]-5-pyridyl)acetate.Type: GrantFiled: July 14, 2004Date of Patent: December 26, 2006Assignee: Sanofi-AventisInventors: André Bousquet, Andrée Musolino
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Patent number: 7038075Abstract: The present invention relates to a production method of (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid which comprises optical resolution of racemic 3-hydroxy-3-(2-phenylethyl)hexanoic acid with an optically active amine of the formula (VIII) wherein R2 is 3,4-dimethoxyphenyl or 2-chlorophenyl. According to the present invention, (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid useful as a starting material of a pharmaceutical agent can be efficiently produced with a high optical purity and a relatively high total yield.Type: GrantFiled: December 4, 2003Date of Patent: May 2, 2006Assignee: Sumitomo Chemical Company, LimitedInventors: Masahide Tanaka, Kozo Matsui, Tadashi Katsura, Mitsuhiro Iwasaki, Hiroshi Maeda, Nobushige Itaya
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Patent number: 7026438Abstract: The invention relates to liquid sulphur-containing antioxidants and to compositions comprising them. The novel lubricant compositions comprise the reaction product of a selected group of 5-tert-butyl-4-hydroxy-3-methyl(or tert-butyl)phenyl substituted carboxylic acid esters with thiodiethylene glycol and a mono-hydroxy alcohol with a carbon chain length higher than 4 C-atoms. The novel lubricant compositions are highly resistant to oxidative degradation and are capable of reducing the negative effects of deposits, such as black sludge, in motor combustion engines, particularly spark ignition internal combustion engines.Type: GrantFiled: November 26, 2003Date of Patent: April 11, 2006Assignee: Ciba Specialty Chemicals Corp.Inventors: Hugo Camenzind, Paul Dubs, Roger Martin, David Eliezer Chasan, Gunnar Demme, James Robbins
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Patent number: 7002037Abstract: The present invention relates to novel resolution methods, which are useful in the preparation of enantiomerically enriched intermediates which in their turn are useful in the prepartion of compounds with a pharmacological effect on the insulin resistance syndrome (IRS). It is such a process that the present inventions sets out to define, and more particularly for the preparation of the (S)-enantioner of certain 2-ethoxy-3-(4-hydroxyphenyl)propanoic acids and derivatives thereof.Type: GrantFiled: November 29, 2000Date of Patent: February 21, 2006Assignee: AstraZeneca ABInventors: Kjell Andersson, Alan Eric Fischer, Panagiotis Ioannidis, Magnus Larsson, Maria Larsson, Sivaprasad Sivadasan
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Patent number: 6946486Abstract: The invention features quaternary ammonium compounds of formula I, described herein, and their use in treating asthma, chronic obstructive pulmonary disorder, allergic rhinitis, and infectious rhinitis.Type: GrantFiled: October 17, 2003Date of Patent: September 20, 2005Assignee: Pharmacia & Upjohn Co.Inventor: John Gregory Slatter
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Patent number: 6939988Abstract: Novel ?-aryl-?-oxysubstituted alkylcarboxylic acids of the formula (I) and compositions containing them. The compounds have hypolipidemic, antihyperglycemic uses.Type: GrantFiled: November 23, 1999Date of Patent: September 6, 2005Assignee: Dr. Reddy's Laboratories LimitedInventors: Braj Bhushan Lohray, Vidya Bhushan Lohray, Ashok Channaveerappa Bajji, Shivaramayya Kalchar, Rajagopalan Ramanujam, Ranjan Chakrabarti
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Patent number: 6921822Abstract: The present invention relates to a process for preparing stereoisomerically enriched 4-aryl-4-hydroxybutanoic acid derivatives by reducing 4-aryl-4-ketobutanoic acid derivatives in the presence of ruthenium-containing catalysts.Type: GrantFiled: June 9, 2003Date of Patent: July 26, 2005Assignee: Bayer AktiengesellschaftInventors: Hans-Christian Militzer, Boris Bosch, Markus Eckert, Benjamin Meseguer
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Patent number: 6916890Abstract: The present invention discloses reworkable epoxy compositions suitable for encapsulation of and underfill for electronic components including (a) the epoxidized reaction product of a multifunctional 1-alkenyl ether or 1-cycloalkenyl ether and an alkenyl carboxylic acid, the epoxidized reaction product having two or more thermally labile alpha-alkoxy ester linkages; and (b) a curing agent for the epoxy component. The epoxy composition, when cured, provides a composition which is thermally reworkable, the weak ?-alkoxy ester linkages providing for the reworkable aspect of the invention.Type: GrantFiled: July 25, 2002Date of Patent: July 12, 2005Assignee: Henkel CorporationInventors: John G. Woods, Susanne D. Morrill
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Patent number: 6897335Abstract: A process for the preparation of 2-oxocarboxylic acid esters represented by the following general formula (I), comprising by oxidizing a 2-hydroxycarboxylic acid ester represented by the following general formula (II) in the presence of a nitroxyl radical represented by the following general formula (III), a hypochlorite, a metal bromide and water with the pH of the reaction system being kept within the range of 5 to 7: (I) (II) (III) wherein R1 and R2 are each independently an alkyl group, an alkenyl group, an alkynyl group, an aryl group or an aralkyl group, which each may be substituted with substituents; and R3 is a hydrogen atom, an alkoxyl group, an aralkyloxy group, an acyloxy group or a hydroxyl group.Type: GrantFiled: June 19, 2002Date of Patent: May 24, 2005Assignee: Kuraray Co., Ltd.Inventors: Fumihiko Okabe, Masahiro Torihara, Yoshin Tamai
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Patent number: 6894186Abstract: Methyl (R)-2-(R1OSO2)-2-(2-chlorophenyl)acetates useful as intermediates in the preparation of methyl (S)-2(2-chlorophenyl)-2-(4,5,6,7-tetrahydrothieno[3,2-c]-5-pyridyl)acetate.Type: GrantFiled: April 29, 2003Date of Patent: May 17, 2005Assignee: Sanofi-SynthelaboInventors: André Bousquet, Andrée Musolino
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Patent number: 6881868Abstract: Compounds of formula (I), wherein R1 and R2 are, independently of one another, H,C1-C6alkyl, C1-C6halogenalkyl, C1-C6alkoxyl, C1-C6alkoxy-C1-C6alkyl, or C1-C6alkoxy-C1-C6alkyloxy, and R3 is C1-C6alkyl, are obtainable in high yiedls by stereoselective addition of R3-substituted propionic acid esters to R1- and R2-substituted benzaldehydes of formula R—CHO to form corresponding 3-R-3-hydroxy-2-R3-propionic acid esters, conversion of the OH group to a leaving group, subsequent regioselective elimination to form 3-R-2-R3-propenic acid esters, and reduction to corresponding 3-R-2-R3-allyl alcohols and their enantioselective hydrogenation, wherein R is (a).Type: GrantFiled: June 26, 2001Date of Patent: April 19, 2005Assignee: Speedel Pharma AGInventors: Stefan Stutz, Peter Herold, Felix Spindler, Walter Weissensteiner, Thomas Sturm
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Patent number: 6867321Abstract: The present invention provides a method for producing compound (XIV) useful as an intermediate for pharmaceutical agents efficiently and economically on an industrial scale without using ozone oxidation and highly toxic reagent, and an intermediate used for this method. Particularly, the present invention provides a method for producing a compound having an absolute configuration represented by the formula (XV) and an enantiomer thereof without using a technique such as optical resolution and the like, and an intermediate used for this method. (1) Compound (XIII) as a starting material is led to compound (I), and after introducing a protecting group, subjected to reduction and cyclization to give compound (XIV). Particularly, compound (XIII) as a material is led to compound (I) via compound (XX) to produce compound (XIV).Type: GrantFiled: December 23, 2003Date of Patent: March 15, 2005Assignee: Sumitomo Chemical Company, LimitedInventors: Tetsuya Ikemoto, Dongguo Piao
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Patent number: 6852874Abstract: A process for catalyzing asymmetric dihydroxylations of olefins employs an Os(VI) complex as a catalytic intermediate in the formation of chiral vicinal diol products. The process requires a chiral bidentate ligand that favors diol formation in the “second cycle” of asymmetric dihydroxylation.Type: GrantFiled: August 28, 2001Date of Patent: February 8, 2005Assignee: The Scripps Research InstituteInventors: K. Barry Sharpless, Malin Andersson, Robert Epple, Valery Fokin
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Publication number: 20040254392Abstract: A method for producing an optically active 3,5-dihydroxyhexanoic acid derivative by stereoselectively reducing an optically active 3-oxo-5-hydroxyhexanoic acid derivative is provided. The method, which requires neither an ultralow-temperature reactor, an incubator, nor protection of the 5-position hydroxy group, is simple and economical.Type: ApplicationFiled: April 13, 2004Publication date: December 16, 2004Inventors: Masanobu Sugawara, Kenji Inoue
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Publication number: 20040248849Abstract: The present invention relates to novel antidiabetic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel 3-aryl-&agr;-oxy substituted propanoic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs and pharmaceutically acceptable compositions containing them. Formula (I) where R1 represents t-butyldimethyl silyl, trimethyl silyl or alkoxyalkyl group; R2 represents hydrogen or substituted or unsubstituted (C1-C6)alkyl group.Type: ApplicationFiled: July 28, 2004Publication date: December 9, 2004Inventors: Rajender Kumar Potlapally, Venkata Rama Murali Krishna Reddy Velagala, Ramabhadra Sarma Mamillapalli, Om Reddy Gaddam
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Patent number: 6812368Abstract: The invention relates to a novel process of diastereoselective hydrogenation of 1,3-hydroxyketones of formula (I) wherein R, R′ and R″ are as defined in claim 1 which is carried out in a solvent in the presence of a magnesium salt, a heterogeneous platinum catalyst and optionally an oxidant.Type: GrantFiled: July 2, 2003Date of Patent: November 2, 2004Assignee: Solvias AGInventors: Martin Studer, Stephan Burkhardt, Ulrike Nettekoven
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Patent number: 6794532Abstract: Process for enantioselectively hydrogenating prochiral ketones to (S)-alcohols using platinum catalysts in the presence of cinchonines or quinidines as modifiers and in the presence of hydrogen, which is characterized in that the modifiers used are cinchonines unsubstituted in the 3-position, 3-ethylidenyl- or 9-methoxycinchonines or derivatives thereof in which the quinoline ring is replaced by other rings.Type: GrantFiled: April 11, 2003Date of Patent: September 21, 2004Assignee: Solvias AGInventors: Martin Studer, Stephan Burkhardt, Andreas Pfaltz, Christian Exner
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Patent number: 6753441Abstract: The invention concerns a method for preparing p-hydroxymandelic compounds optionally substituted and their derivatives. More particularly, it concerns a method for preparing p-hydroxymandelic acid and methoxy-3 p-hydroxymandelic acid and their derivatives. The invention concerns a method for preparing p-hydroxymandelic compounds optionally substituted and their derivatives, which consists in condensing in water, in the presence of an alkaline agent, an aromatic compound bearing at least a hydroxyl group and whereof the position in para is free, with glyoxylic acid, said method being characterised in that the reaction is carried out in the presence of an efficient amount of a compound bearing at least two carboxylic functions.Type: GrantFiled: March 14, 2001Date of Patent: June 22, 2004Assignee: Rhodia ChimieInventors: Isabelle Jouve, Frederic Fournet, Jean Fragnon
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Publication number: 20040116519Abstract: The invention features quaternary ammonium compounds of formula I, described herein, and their use in treating asthma, chronic obstructive pulmonary disorder, allergic rhinitis, and infectious rhinitis.Type: ApplicationFiled: October 17, 2003Publication date: June 17, 2004Inventor: John Gregory Slatter
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Publication number: 20030233001Abstract: The invention relates to a process for the manufacture of a compound of formula 1Type: ApplicationFiled: May 2, 2003Publication date: December 18, 2003Inventor: Thomas Storz
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Patent number: 6660879Abstract: A novel 3-aryl-2-hydroxypropionic acid derivative, a process and intermediate for its manufacture, pharmaceutical preparations containing it and the use of the compound in clinical conditions associated with insulin resistance.Type: GrantFiled: January 4, 2002Date of Patent: December 9, 2003Assignee: AstraZeneca ABInventor: Kjell Andersson
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Patent number: 6653258Abstract: Fungicidal compounds of the formula (I): and stereoisomers thereof, wherein R1 is optionally substituted aryl or optionally substituted heteroaryl; Y is oxygen, sulphur or NR4; R2, R3 and R4, which may be the same or different, are hydrogen, C1-4 alkyl or C2-4 alkenyl; X is halogen, C1-4 alkyl, C2-4 alkenyl, C1-4 alkoxy, nitro or cyano, and n is 0 or an integer of 1 to 4; provided that when Y is oxygen, n is 0 and R1 is unsubstituted phenyl at least one of R2 and R3 is other than hydrogen or methyl.Type: GrantFiled: March 27, 1995Date of Patent: November 25, 2003Assignee: Syngenta LimitedInventors: John M Clough, Christopher R A Godfrey, Paul J de Fraine, Michael G Hutchings, Vivienne M Anthony
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Patent number: 6646168Abstract: The present invention provides a supported osmate useful as a reusable catalyst in the preparation of vicinal diols. The present invention also relates to a process for the preparation of supported osmates of the formula (S—NR3)2OsO4.nH2O wherein S is a support, R is an alkyl group, n is the number of water molecules and use thereof in the preparation of vicinal diols by asymmetric dihydroxylation (AD) of olefins in presence of cinchona alkaloid compounds.Type: GrantFiled: March 13, 2002Date of Patent: November 11, 2003Assignee: Council of Scientific and Industrial ResearchInventors: Boyapati Manoranjan Choudary, Naidu Sreenivasa Chowdari, Mannepalli Lakshmi Kantam, Kondapuram Vijaya Raghavan
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Patent number: 6605716Abstract: A process for the preparation of hydroxy and amino compounds, in which, in a first step, an aldehyde, ketone or imine is reacted in a Reformatsky reaction with a reactive halogen compound and zinc, in carboxylic esters as solvents, the reactive halogen compound being brought into contact with the zinc at the same time as or after contact with the aldehyde, ketone or imine, and in a second step, the reaction product of the first step is hydrolyzed.Type: GrantFiled: June 26, 2001Date of Patent: August 12, 2003Assignee: Consortium fuer Elektrochemische Industries, GmbHInventors: Klaus Sorger, Hermann Petersen
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Patent number: 6586463Abstract: Compounds having the general structure: which are useful for the treatment of a variety of diseases and conditions, such as bone disorders.Type: GrantFiled: September 4, 2001Date of Patent: July 1, 2003Assignee: The Procter & Gamble CompanyInventors: Mitchell Anthony deLong, David Lindsey Soper, John August Wos, Biswanath De
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Patent number: 6586468Abstract: A &ohgr;-substituted phenyl-prostaglandin of formula (I), a process for the preparation thereof, a mediciament comprising it as active ingredient (all symbols have the same meaning as described in the specification). The compounds of the formula (I) bind strongly in PGE2 receptor (especially subtype EP4) and therefore are useful for the prophylaxis and/or treatment of immune diseases (autoimmune diseases (amyotrophic lateral sclerosis (ALS) etc.), post-transplantation graft rejection, etc.), asthma, abnormal bone formation, neurocyte death, pulmopathy, hepatopathy, etc. They are also related to sleeping disorders and platelet coagulations, and therefore they are also applicable to these diseases.Type: GrantFiled: June 11, 2001Date of Patent: July 1, 2003Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Toru Maruyama, Shuichi Ohuchida
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Patent number: 6583310Abstract: A non-catalytic process for producing esters, the process comprising reacting an ammonium salt of a carboxylic acid with an alcohol and removing ammonia from the reaction mixture. Selectivities for the desired ester product can exceed 95 percent.Type: GrantFiled: February 22, 2002Date of Patent: June 24, 2003Assignee: The United States of America as represented by the United States Department of EnergyInventor: Yuval Halpern
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Patent number: 6576663Abstract: Compositions and methods for the treatment of dry eye and related diseases utilizing 6-keto-PGF1&agr; and its analogs are disclosed.Type: GrantFiled: March 23, 2001Date of Patent: June 10, 2003Assignee: Alcon, Inc.Inventor: Peter G. Klimko
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Patent number: 6566547Abstract: This invention relates to derivatives of acrylic acid useful as fungicides, to processes for preparing them, to fungicidal compositions containing them, and to methods of combating fungi, especially fungal infections in plants, using them.Type: GrantFiled: October 11, 1985Date of Patent: May 20, 2003Assignee: Zeneca LimitedInventors: Michael J Bushell, Kevin Beautement, John M Clough, Vivienne M Anthony, Paul deFraine, Christopher R Godfrey
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Patent number: 6559335Abstract: The present invention relates to an improved process for the preparation of 3-aryl-2-hydroxy propanoic acid derivatives of the formula (1) useful as an intermediate for the preparation of many pharmaceutically active compounds.Type: GrantFiled: April 17, 2001Date of Patent: May 6, 2003Assignee: Dr. Reddy's Laboratories LimitedInventors: Potlapally Rajender Kumar, Siripragada Mahender Rao, Kotra Narasimha Murthy, Sirisilla Raju, Mamillapalli Ramabhadra Sarma, Gaddam Om Reddy
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Patent number: 6555577Abstract: The present invention relates to compounds of the general formula (I) The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).Type: GrantFiled: January 26, 2001Date of Patent: April 29, 2003Assignee: Novo Nordisk A/SInventors: John Patrick Mogensen, Per Sauerberg, Paul Stanley Bury, Lone Jeppesen, Ingrid Pettersson
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Patent number: 6552234Abstract: The present invention discloses a process for the preparation of a novel heterogeneous osmate catalyst of the general formula (S—NR3)2OsO4.nH2O wherein S is a support, R is an alkyl group, n is the number of water molecules by reacting potassium osmate with supported quaternary ammonium species in an aqueous solvent.Type: GrantFiled: October 23, 2001Date of Patent: April 22, 2003Assignee: Council of Scientific and Industrial ResearchInventors: Boyapati M. Choudary, Naidu S. Chowdari, Mannepalli L. Kantam, Kondapuram V. Raghavan
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Patent number: 6531596Abstract: The present invention relates to an improved process for the preparation of novel antidiabetic compounds having formula (1) where R1 represents hydrogen or lower alkyl group and X represents hydrogen or halogen atom.Type: GrantFiled: May 30, 2001Date of Patent: March 11, 2003Assignee: Dr. Reddy's Laboratories Ltd.Inventors: Mahender Rao Siripragada, Prabhakar Chebiyyam, Rajender Kumar Potlapally, Chandra Sekhar Batchu, Ramabhadra Sarma Mamillapalli, Om Reddy Gaddam
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Patent number: 6495217Abstract: The invention relates to chiral compounds of formula I wherein R1, R2, X, Y1 and Y2 have the meanings defined herein, as well as to liquid crystalline mixtures comprising at least one chiral compound of formula I.Type: GrantFiled: October 4, 1999Date of Patent: December 17, 2002Assignee: Merck Patent GmbHInventor: Louise Farrand
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Patent number: 6492550Abstract: Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula where X, Z, X1, R1, R2, Ra and Rb are as defined in the specification.Type: GrantFiled: February 8, 2001Date of Patent: December 10, 2002Assignee: Bristol-Myers Squibb CompanyInventors: Jacques Banville, Serge Plamondon, Yonghua Gai, Neelakantan Balasubramanian
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Patent number: 6492545Abstract: A novel process in which an optically active alcohol compound having a desired absolute configuration and a high optical purity can be obtained by asymmetrically hydrogenating a &bgr;-keto acid compound through a simple operation. An optically active alcohol represented by general formula (III) as defined is obtained by asymmetrically hydrogenating a &bgr;-keto ester compound represented by general formula (I) as defined in the presence of at least one ruthenium complex having as a ligand an optically active tertiary diphosphine compound represented by general formula (II) as defined.Type: GrantFiled: July 23, 2001Date of Patent: December 10, 2002Assignee: Takasago International CorporationInventors: Takao Saito, Tohru Yokozawa, Kazuhiko Matsumura, Noboru Sayo
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Publication number: 20020177726Abstract: The present invention relates to an improved process for the preparation of 3-aryl-2-hydroxy propanoic acid derivatives of the formula (1) 1Type: ApplicationFiled: April 17, 2001Publication date: November 28, 2002Applicant: DR. REDDY'S RESEARCH FOUNDATIONInventors: Potlapally Rajender Kumar, Siripragada Mahender Rao, Kotra Narasimha Murthy, Sirisilla Raju, Mamillapalli Ramabhadra Sarma, Gaddam Om Reddy
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Patent number: 6451859Abstract: Compounds having a structure according to the following formula: are effective in treating disorders such as bone disorders and glaucoma in a subject in need thereof.Type: GrantFiled: August 29, 2001Date of Patent: September 17, 2002Assignee: The Procter & Gamble CompanyInventors: Mitchell Anthony deLong, David Lindsey Soper, John August Wos, Biswanath De
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Patent number: 6444850Abstract: A fungicidal compound of formula (I) having a fluorovinyloxyphenyl moiety and stereoisomers thereof are useful for protecting crops from fungal diseases: wherein: X is CH or N; Y is O or S; Z is O or NH; R1 is hydrogen or CF3; and R2 is hydrogen, a C1-10 alkyl, naphthyl, thiophenyl or a phenyl group optionally carrying one or more substituents selected from the group consisting of C1-6 alkyl, halogen-substituted C1-6 alkyl, C1-6 alkoxy, phenoxy, halogen, and methylenedioxy radicals.Type: GrantFiled: February 8, 2000Date of Patent: September 3, 2002Assignee: Korea Research Institute of Chemical TechnologyInventors: Chwang-Siek Pak, Bum-Tae Kim, No-Kyun Park, Gyung-Ja Choi, Heung-Tae Kim
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Patent number: 6414179Abstract: Inhibitors of the cytosolic phospholipase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula where X, Z, R1, R2, R3, R4, Ra and Rb are as defined in the specification.Type: GrantFiled: March 23, 2001Date of Patent: July 2, 2002Assignee: Bristol-Myers Squibb CompanyInventors: Jacques Banville, Anne Marinier, Yonghua Gai, Serge Plamondon, Stephan Roy, Neelakantan Balasubramanian
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Patent number: 6399770Abstract: A process for preparing a &bgr;-hydroxyester comprising reducing a &bgr;-keto ester in the presence of a salt of ammonium borohydride.Type: GrantFiled: June 6, 2000Date of Patent: June 4, 2002Assignee: Otsuka Kagaku Kabushiki KaishaInventor: Yutaka Kameyama
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Publication number: 20020049350Abstract: A single batch process for preparing (R)-benzyl-4-hydroxy-2-pentynoate by reacting (R)-3-butyn-2-ol with 1,1,1,3,3,3-hexamethyldisilazane to silylate the starting alcohol, followed by deprotonation with an alkyl lithium compound, then a reaction with a haloformate compound, and finally a hydrolysis reaction to arrive at the product ester.Type: ApplicationFiled: June 26, 2001Publication date: April 25, 2002Inventors: Xiaoyong Fu, Chou-Hong Tann, T.K. Thiruvengadam, Jianguo Yin, Timothy L. McAllister, Cesar Colon