Carbamic Acids Or Salts Thereof Patents (Class 562/555)
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Patent number: 11667527Abstract: A method for producing a solution of ammonium carbamate is provided. The method comprises reacting ammonium hydroxide with sodium bicarbonate. The method avoids the complications of using carbon dioxide and can be carried out using standard equipment. The resulting solution of ammonium carbamate can be used to form a biocide by mixing with a hypochlorite oxidant.Type: GrantFiled: June 24, 2020Date of Patent: June 6, 2023Assignee: A.Y. LABORATORIES LTD.Inventor: Ayala Barak
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Patent number: 9890114Abstract: There is provided a urea synthesis method having excellent reliability and productivity with the amount of oxygen used as a corrosion-resistant agent minimized without using special duplex stainless steel. In a urea synthesis apparatus having a synthesis tower, a stripper, and a condenser, general-purpose austenitic-ferritic duplex stainless steel with Cr content: 21 to 26 wt %, Ni content: 4.5 to 7.5 wt %, Mo content: 2.5 to 3.5 wt %, N content: 0.08 to 0.30 wt %, C content: 0.03 wt % or less, Si content: 1.0 wt % or less, Mn content: 2.0 wt % or less, P content: 0.04 wt % or less, and S content: 0.03 wt % is used as a urea synthesis apparatus material in at least some of parts where the urea synthesis apparatus comes into contact with a fluid having corrosiveness, and oxygen feed concentration with respect to carbon dioxide is 100 to 2,000 ppm.Type: GrantFiled: November 24, 2015Date of Patent: February 13, 2018Assignee: TOYO ENGINEERING CORPORATIONInventors: Masashi Takahashi, Eiki Nagashima
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Publication number: 20150094490Abstract: The present invention relates to the synthesis of a novel compound, in which liquid hydrazine and the derivatives thereof react with excess carbon dioxide to enable the carbon dioxide to chemically bond to the hydrazine and the derivatives thereof. To this end, high-pressure carbon dioxide is used to synthesize hydrazine and the derivatives thereof to which the carbon dioxide is bonded in a pure form with no water and no by-product. Furthermore, the present invention provides a method for utilizing the above-described compounds by reacting the compounds with carbonyl compounds.Type: ApplicationFiled: September 12, 2014Publication date: April 2, 2015Inventors: Nam Hwi Hur, Byeong No Lee
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Publication number: 20140120013Abstract: One aspect of the present invention relates to salts that are room-temperature ionic liquids (RTILs), methods of making them, and methods of using them in connection with temporary or permanent gas sequestration. Another aspect of the present invention relates to a class of solvents which can be transformed into RTILs by exposure to a gas, and methods of using them in connection with temporary or permanent gas sequestration.Type: ApplicationFiled: November 5, 2013Publication date: May 1, 2014Applicant: Georgetown UniversityInventors: Tao Yu, Richard G. Weiss, Taisuke Yamada, Mathew George
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Patent number: 8329853Abstract: The invention relates to an improved process for the preparation of poly-?-glutamic acids which comprises the polymerization of tertiary ?-esters of ?-glutamic acid N-carboxy anhydride with appropriate solvents and initiators, followed by acid hydrolysis of the resulting poly-?-glutamic acid-?-ester. The process is particularly advantageous in that it allows one to carefully control the molecular weight of the resulting poly-?-glutamic acid. The invention also relates to poly-?-glutamic acids capped at the amino terminus with carboxylic acids or amino acids and to a process for the preparation thereof.Type: GrantFiled: December 10, 2010Date of Patent: December 11, 2012Assignee: Cell Therapeutics, Inc.Inventors: Marc McKennon, Giovanni Da Re, Luca Feliciotti, Marco Artico, Gianluca Pardi, Mario Grugni
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Publication number: 20110275108Abstract: An objective of the present invention is to provide a glycan releasing method which can be applied to construction of a system for automation of glycan analysis, and particularly a glycan releasing method capable of analyzing an O-linked glycan. The objective could be achieved as a result of finding that the pH is lowered by using an ammonium salt or ammonium ion in the absence of concentrated aqueous ammonia, not using concentrated aqueous ammonia, thus drastically avoiding an undesired side reaction such as a peeling reaction or the like.Type: ApplicationFiled: August 11, 2009Publication date: November 10, 2011Applicant: National University Corporation Hokkaido UniversitInventors: Shin-Ichiro Nishimura, Yoshiaki Miura
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Publication number: 20110195945Abstract: Compositions and methods of treating or preventing disease or injury to a human patient or biological material undergoing ischemic or hypoxic conditions.Type: ApplicationFiled: February 11, 2011Publication date: August 11, 2011Applicant: Ikaria, Inc.Inventors: Fuqiang Ruan, Edward A. Wintner, Thomas L. Deckwerth
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Patent number: 7893298Abstract: The invention relates to a method for concentrating an aqueous ammonium carbamate stream, which has been formed in a process for the preparation of urea, has a pressure between 0.20 MPa and 0.9 MPa, a temperature between 35° C. and 95° C., and contains at least 25 wt. % H2O, comprising: a pressure increase step, in which the aqueous ammonium carbamate stream is increased in pressure to a pressure between 1.0 MPa and 7 MPa; a condensation step, in which the aqueous ammonium carbamate stream is contacted with a gas stream, which has been formed in a process for the preparation of melamine and which consists essentially of NH3, CO2 and optionally H2O and has a lower H2O content than the aqueous ammonium carbamate stream, the gas stream being absorbed in the aqueous ammonium carbamate stream in such a way that a concentrated ammonium carbamate stream is formed that contains between 15 and 35 wt. % H2O; a discharge step, in which the concentrated ammonium carbamate stream is separated and discharged.Type: GrantFiled: May 15, 2006Date of Patent: February 22, 2011Assignee: Stamicarbon B.V.Inventors: Johannes Henricus J. H. Mennen, Tjay Tjien T. T. Tjioe
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Publication number: 20100105686Abstract: The present invention relates to new sulfonamide derivatives of formula (I) wherein R1-R8 and Z are as defined in the claims, and optical antipodes or racemates and/or salts and/or hydrates and/or solvates thereof, which are selective antagonists of bradykinin B1, to processes for producing these same compounds, pharmacological compositions containing them and to their use in therapy or prevention of painful and inflammatory conditions.Type: ApplicationFiled: October 27, 2007Publication date: April 29, 2010Inventors: Gyula Beke, Eva Bozo, Sandor Farkas, Katalin Hornok, Gyorgy Keseru, Eva Schmidt, Eva Szentirmay, Istvan Vago, Monika Vastag
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Patent number: 7645757Abstract: The present invention is directed to compounds and compositions for the treatment of neurological diseases that cause neurogenic and neuropathic pain, inflammatory diseases, renal ishaemia, cardiovascular disease and other pathologies caused by the presence of endogenous cannabinoids and or other substrates resulting from the metabolic activities of fatty acid amido hydrolase (FAAH). These compounds are represented by the formula alkylene group; a salt thereof, or a hydrate or a solvate of said compound or said salt; where the variables are as defined in the attached specification.Type: GrantFiled: August 14, 2006Date of Patent: January 12, 2010Assignee: sanofi-aventisInventors: Ahmed Abouabdellah, Regine Bartsch-Li, Christian Hoornaert, Antoine Ravet
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Publication number: 20090281352Abstract: Ethylenedamine derivatives having a halogenated carbamate group and an acyl group can be produced by performing the catalytic hydrogenation of an aminonitrile having a halogen-substituted carbamate group in the presence of an acid and then performing the acylation of the resulting product. The aminonitrile (i.e., a starting material) can be prepared in a high yield by performing the halogenated carbamatation of an amino acid amide in the presence of water and then reacting the resulting product with a deoxidizing agent such as a vilsmeier reagent.Type: ApplicationFiled: March 27, 2007Publication date: November 12, 2009Applicant: Mitsui Chemicals, Inc.Inventors: Hideki Umetani, Toshiyuki Kohno
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Patent number: 7615280Abstract: A method and product to detect a starting edge of a roll of material are described. The roll of material includes a composition, an apparatus, or a combination thereof, which provides the detectable edge.Type: GrantFiled: June 14, 2004Date of Patent: November 10, 2009Inventors: Arash Behravesh, Esfandiar Behravesh
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Publication number: 20090069597Abstract: The invention relates to a method for concentrating an aqueous ammonium carbamate stream, which has been formed in a process for the preparation of urea, has a pressure between 0.20 MPa and 0.9 MPa, a temperature between 35° C. and 95° C., and contains at least 25 wt. % H2O, comprising: a pressure increase step, in which the aqueous ammonium carbamate stream is increased in pressure to a pressure between 1.0 MPa and 7 MPa; a condensation step, in which the aqueous ammonium carbamate stream is contacted with a gas stream, which has been formed in a process for the preparation of melamine and which consists essentially of NH3, CO2 and optionally H2O and has a lower H2O content than the aqueous ammonium carbamate stream, the gas stream being absorbed in the aqueous ammonium carbamate stream in such a way that a concentrated ammonium carbamate stream is formed that contains between 15 and 35 wt. % H2O; a discharge step, in which the concentrated ammonium carbamate stream is separated and discharged.Type: ApplicationFiled: May 15, 2006Publication date: March 12, 2009Inventors: Johannes Henricus J.H. Mennen, Tjay Tjien T.T Tjioe
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Publication number: 20080274116Abstract: The present invention is related to a compound according to formula (I), wherein R1 and R2 are each and independently selected from the group comprising alkyl; n is any integer between 1 and 4; R3 is an acyl selected from the group comprising lysyl, ornithyl, 2,4-diaminobutyryl, histidyl and an acyl moiety according to formula (II), wherein m is any integer from 1 to 3 and YÉ is a pharmaceutically acceptable anion.Type: ApplicationFiled: May 6, 2005Publication date: November 6, 2008Applicant: SILENCE THERAPEUTICS AGInventors: Oliver Keil, Jorg Kaufmann
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Publication number: 20080248175Abstract: The invention relates to gamma-glutamyl and beta-asparagyl peptide compounds of formula (I) that provide a kokumi flavour to consumables and flavour compositions, and to consumables and flavour compositions comprising such compounds. Enzymatic methods to prepare the compounds are provided.Type: ApplicationFiled: October 11, 2006Publication date: October 9, 2008Applicant: GIVAUDAN SAInventors: Thomas Frank Hofmann, Andreas Dunkel
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Publication number: 20080166777Abstract: The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate by enzymes that contribute to its synthesis. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.Type: ApplicationFiled: July 16, 2007Publication date: July 10, 2008Applicant: BASF AktiengesellschaftInventors: R. Rogers Yocum, Thomas A. Patterson, Janice G. Pero, Theron Hermann
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Patent number: 7238834Abstract: The present invention relates to substantially pure piperidine derivative compounds of the formulae: wherein R1 is hydrogen or hydroxy; R2 is hydrogen; or R1 and R2 taken together form a second bond between the carbon atoms bearing R1 and R2; R3 is —COOH or —COOR4; R4 has 1 to 6 carbon atoms; A, B, and D are the substituents of their respective rings each of which may be different or the same and are hydrogen, halogens, alkyl, hydroxy, alkoxy, or other substituents. A process of preparing such piperidine derivative compounds in substantially pure form is also disclosed.Type: GrantFiled: October 14, 2005Date of Patent: July 3, 2007Assignee: AMR Technology, Inc.Inventor: Thomas E. D'Ambra
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Patent number: 7060851Abstract: Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtaining such key chiral amine intermediates enantiomerically, diastereomerically and chemically pure. The method is suitable for large scale (multikilogram) productions. This invention also encompasses organic acid and inorganic acid salts of the amine intermediates.Type: GrantFiled: October 12, 2004Date of Patent: June 13, 2006Assignee: G.D. Searle & Co.Inventors: John S Ng, Claire A Przybyla, Shu-Hong Zhang
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Patent number: 7019003Abstract: Novel PDF inhibitors and novel methods for their use are provided.Type: GrantFiled: March 1, 2002Date of Patent: March 28, 2006Assignee: Smithkline Beecham CorporationInventors: Jia-Ning Xiang, Siegfried B. Christensen, IV, Jinhwa Lee, Daniel J. Mercer
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Patent number: 6914157Abstract: The invention relates to a method for obtaining an ammonium carbamate solution from a gas mixture that contains more than 40 wt. % NH3, less than 50 wt. % CO2 and less than 40 wt. % H2O and has a pressure between 0.1 MPa and 4 MPa, comprising a compression step, in which the pressure of the gas mixture is increased to a pressure between 0.5 MPa and 25 MPa, and an absorption step.Type: GrantFiled: July 3, 2002Date of Patent: July 5, 2005Assignee: DSM IP Assets B.V.Inventor: Guillaume Mario Hubert Jozef Lardinois
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Patent number: 6903232Abstract: This invention relates to a novel process to obtain highly pure 4-(cyclopropylcarbonyl)-?,?-dimethylphenylacetic acid of Formula I through crystallization from a mixture of para and meta regioisomers of Formula I and II in cyclohexane, whereby the amount of undesired meta isomer, 3-(cyclopropylcarbonyl)-?,?-dimethylphenylacetic acid of Formula II is decreased to below 0.5%. The compound of Formula I is a key intermediate for the preparation of high purity terfenadine carboxylate, which is a known antihistaminic.Type: GrantFiled: July 2, 2003Date of Patent: June 7, 2005Assignee: Aurobindo Pharma Ltd.Inventors: Ramesh Dandala, Umashankar Das, Divvela Venkata Naga Srinivasa Rao, Meenakshisunderam Sivakumaran
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Patent number: 6806384Abstract: The present invention provides a production method of an optically active &bgr;-amino-&agr;-hydroxycarboxylic acid, which includes the following steps (a)-(c): (a) treating an optically active N-carbamate protected &bgr;-amino epoxide with an acid to give an optically active 5-hydroxymethyl-2-oxazolidinone; (b) oxidizing the resulting compound in the presence of 2,2,6,6-tetramethyl-1-piperidinyloxy and hypochlorite to give an optically active 4-benzyl-2-oxo-5-oxazolidinecarboxylic acid; and (c) treating the 4-benzyl-2-oxo-5-oxazolidinecarboxylic acid with a base, and a production method of an optically active N-carbamate protected &bgr;-amino-&agr;-hydroxycarboxylic acid which includes protection of the amino group with a carbamate type protecting group. The industrial production method of the present invention can produce these compounds efficiently.Type: GrantFiled: April 10, 2002Date of Patent: October 19, 2004Assignee: Ajinomoto Co., Inc.Inventors: Yasuyuki Otake, Tomoyuki Onishi, Sachiko Oka, Daisuke Takahashi
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Patent number: 6803378Abstract: Novel diketoacid compounds of Formula I are provided which are useful as HIV integrase inhibitors and for the treatment of AIDS or ARC.Type: GrantFiled: September 25, 2002Date of Patent: October 12, 2004Assignee: Bristol-Myers Squibb CompanyInventors: Michael A. Walker, Timothy D. Johnson, Nicholas A. Meanwell, Jacque Banville
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Publication number: 20040127624Abstract: The present invention relates to a bicarboxyl monomer of formula (I), 1Type: ApplicationFiled: December 17, 2003Publication date: July 1, 2004Applicant: National Taiwan Normal UniversityInventors: Lung-Pin Chen, Kung-Chung Hsu
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Patent number: 6703498Abstract: Water-soluble metal ion affinity compounds and methods for using the same are provided. The subject compounds include an aspartate based metal chelating ligand bonded to a water-soluble polymeric substrate, where the ligand is complexed with a metal ion. In certain embodiments, the subject compounds further include a member of a signal producing system, e.g., a directly or an indirectly detectable label moiety. Also provided are water-insoluble supports having the subject compounds present on, e.g., immobilized on, at least one surface thereof. The subject compounds find use in a variety of different applications, including analyte detection and analyte purification applications.Type: GrantFiled: June 20, 2002Date of Patent: March 9, 2004Assignee: Clontech Laboratories, Inc.Inventor: Grigoriy S. Tchaga
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Patent number: 6686494Abstract: A method for preparing S-alkyl and S-aryl thiocarbamates comprising reacting a precursor thiol reagent with trichloroacetyl chloride to produce an S-alkyl and S-aryl trichloroacetyl thioester intermediate, which is reacted with an amine to yield the corresponding thiocarbamate product. Also disclosed is the method for preparing S-alkyl and S-aryl thiocarbamates comprising reacting an amine with trichloroacetyl chloride to produce a trichloroacetamide intermediate, which is then reacted with the precursor thiol to yield the corresponding thiocarbamate product.Type: GrantFiled: March 6, 2003Date of Patent: February 3, 2004Assignee: The United States of America as represented by the Secretary of the NavyInventors: James W. Wynne, Arthur W. Snow
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Patent number: 6399809Abstract: Process for the preparation of amino acid derivatives of the general formula I where R1-R4 are as defined herein, from the corresponding malonic acid monoester amides of the general formula II by Hofmann degradation using a hypohalite in an aqueously basic medium, which comprises carrying out the reaction in the presence of an alcohol or amine and using the hypohalite in amounts of from 1.0 to 1.5 equivalents and the base in amounts of from 0.8 to 4.0 equivalents per mole of starting material II.Type: GrantFiled: April 21, 2000Date of Patent: June 4, 2002Assignee: Degussa AGInventors: Wolfgang Kleemiss, Marcel Feld
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Patent number: 6207868Abstract: This invention is to develop novel transition metal catalysts for the practical synthesis of important chiral molecules. The invention emphasizes asymmetric catalysis based on chiral bidentate phosphine ligands with cyclic ring structures which could be used to restrict conformational flexibility of the ligands and thus the efficiency of chiral transfer can be enhanced through the ligand rigidity.Type: GrantFiled: November 12, 1998Date of Patent: March 27, 2001Assignee: The Penn State Research FoundationInventor: Xumu Zhang
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Patent number: 6063955Abstract: A method for producing an optically active erythro-3-amino-2-hydroxybutyric ester as an important intermediate of pharmaceutical agents, specifically HIV protease inhibitor, in high purity and in high yield. The method includes producing an optically active erythro-3-amino-2-hydroxybutyric ester by oxidizing the hydroxyl group at the 2-position of an optically active 3-amino-2-hydroxybutyric ester, optically active at the 3-position, as represented by formula (I): ##STR1## (wherein R.sup.1 represents a phenyl group or a cyclohexyl group; R.sup.2 represents a protective group and R.sup.3 represents an unsubstituted or substituted alkyl residue; the steric configuration of *1 represents S configuration or R configuration), and then reducing erythro-selectively the resulting product by using aluminum alkoxide.Type: GrantFiled: February 3, 1999Date of Patent: May 16, 2000Assignee: Nippon Kayaku Kabushiki KaishaInventors: Hisao Satoh, Kenichi Yamamoto
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Patent number: 6034271Abstract: Amphiphilic amphoteric compounds of formula (I) ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and n are as defined in the disclosure.Type: GrantFiled: August 31, 1998Date of Patent: March 7, 2000Assignee: Huels AktiengesellschaftInventor: Klaus Kwetkat
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Patent number: 6007865Abstract: The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins, and which additionally reverse pre-formed crosslinks in the advanced glycosylation endproducts by cleaving alpha-dicarbonyl-based protein crosslinks present in the advanced glycosylation endproducts. Certain agents useful are thiazolium salts. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated. A novel immunoassay for detection of the reversal of the nonenzymatic crosslinking is also disclosed.Type: GrantFiled: November 19, 1997Date of Patent: December 28, 1999Assignees: Alteon Inc., The Picower Institute for Medical ResearchInventors: Anthony Cerami, Peter C. Ulrich, Dilip R. Wagle, San-Bao Hwang, Sara Vasan, John J. Egan
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Patent number: 5990170Abstract: The following description concerns a therapeutic method for the treatment of diseases connected with the modulation of the cannabinoid peripheral receptor, comprising administering amidic derivatives of mono and bicarboxylic acids with aminoalcohols or arninoethers selectively active on said receptor.Type: GrantFiled: September 30, 1997Date of Patent: November 23, 1999Assignee: Lifegroup S.p.A.Inventors: Francesco Della Valle, Alberta Leon, Gabriele Marcolongo, Silvana Lorenzi
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Patent number: 5981797Abstract: Diamine carbamates are prepared by spraying liquid diamine into carbon dioxide gas, in the optional presence of a propellant.Type: GrantFiled: August 4, 1998Date of Patent: November 9, 1999Assignee: E. I. du Pont de Nemours and CompanyInventor: John Harry Orth
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Patent number: 5932595Abstract: The present invention relates to compounds of Formula I: ##STR1## that are matrix metalloprotease inhibitors, pharmaceutical compositions containing them, methods for their use and methods of preparing these compounds.Type: GrantFiled: December 18, 1996Date of Patent: August 3, 1999Assignees: Syntex (U.S.A.) Inc., Agouron Pharmaceuticals, Inc.Inventors: Steven Lee Bender, Chris Allen Broka, Jeffrey Allen Campbell, Arlindo Lucas Castelhano, Lawrence Emerson Fisher, Robert Than Hendricks, Keshab Sarma
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Patent number: 5932616Abstract: The present invention provides the compound having the structure: ##STR1## wherein each of R.sub.1 and R.sub.2 are independently the same as or different from each other; when R.sub.1 and R.sub.2 are the same, each is a substituted or unsubstituted arylamino, cycloalkylamino, pyridineamino, piperidino, 9-purine-6-amine, or thiozoleamino group; when R.sub.1 and R.sub.2 are different, R.sub.1 =R.sub.3 --N--R.sub.4, wherein each of R.sub.3 and R.sub.4 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted, branched or unbranched alkyl, alkenyl, cycloalkyl, aryl, alkyloxy, aryloxy, arylalkyloxy, or pyridine group, or R.sub.3 and R.sub.4 bond together to form a piperidine group and R.sub.2 is a hydroxylamino, hydroxyl, amino, alkylamino, dialkylamino or alkyloxy group; and n is an integer from about 4 to about 8.Type: GrantFiled: April 4, 1994Date of Patent: August 3, 1999Assignees: Sloan-Kettering Institute for Cancer Research, The Trustees of Columbia Univerisity in the City of New YorkInventors: Ronald Breslow, Paul A. Marks, Richard A. Rifkind, Branko Jursic
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Patent number: 5905127Abstract: Mesogens are provided based on substituted unsaturated carboxylic acids such as acrylic and methacrylic acid. Substitution of a variety of hydrophobic tails onto the carboxylic acid or acid derivative via the vinyl carbon proximal to the carbonyl of the carboxylic acid results in mesogens that are capable of forming thermotropic and single-phase lyotropic mesophases over a broad range of compositions. The mesophases can be polymerized to lock in the ordered phases.Type: GrantFiled: April 8, 1997Date of Patent: May 18, 1999Assignee: The University of Southern MississippiInventors: Robert Y Lochhead, Lon J Mathias
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Patent number: 5840972Abstract: A process is disclosed for the preparation of N.sup.G -monoalkyl-L-arginine and related compounds and salts thereof, for example N.sup.G -monomethyl-L-arginine by reacting N-alkylaminoiminomethane sulphonic acid of formula (II) with an amino acid of formula (III).Type: GrantFiled: February 22, 1995Date of Patent: November 24, 1998Assignee: Glaxo Wellcome Inc.Inventors: Rajnikant Patel, Amrik Singh Mahal, Donald Lloyd Winston Burford
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Patent number: 5773465Abstract: Tartronic acid acetalic ethers and esters of the general formula: ##STR1## are provided and are useful in treatment of bone dysmetabolism. As examples, Ra and Rb may be hydrogen, B is a C.sub.2 -C.sub.12 acyl group, R is phenyl and n is 0-12.Type: GrantFiled: March 12, 1997Date of Patent: June 30, 1998Assignee: Dompe Farmaceutici S.p.A.Inventors: Carmelo A. Gandolfi, Lorella Cotini, Marco Mantovanini, Gianfranco Caselli, Gaetano Clavenna, Claudio Omini
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Patent number: 5614503Abstract: A nucleic acid transporter to deliver a nucleic acids into cells, comprising a cationic compound having a cationic head group for binding the nucleic acid and a lipid tail for association with the membrane. A cationic compound usually is a polyamine or a short basic peptide. The lipid tail is usually selected from the group consisting of plant steroid, animal steroid, isoprenoid compound, aliphatic lipid, pore forming protein, pore forming peptides and fusogenic peptides. The cationic head and the lipid tail are linked through a carbamate linkage. When polyamine is used, it is preferably either spermidine or spermine and the nucleic acid can be any of a variety, including triplex forming oligonucleotides, antisense oligonucleotide, aptamers, ribozymes, plasmids and DNA for gene therapy. Also described is a method for treating individuals using the transporter linked to a therapeutic nucleic acid.Type: GrantFiled: June 6, 1995Date of Patent: March 25, 1997Assignee: Aronex Pharmaceuticals, Inc.Inventors: Nilabh Chaudhary, Krishna Jayaraman, Veeraiah Bodepudi, Michael E. Hogan
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Patent number: 5581011Abstract: The present invention relates to substantially pure piperidine derivative compounds of the formulae: ##STR1## wherein R.sub.1 is hydrogen or hydroxy;R.sub.2 is hydrogen;or R.sub.2 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ;R.sub.3 is --COOH or --COOR.sub.4 ;R.sub.4 has 1 to 6 carbon atoms;A, B, and D are the substituents of their respective rings each of which may be different or the same and are hydrogen, halogens, alkyl, hydroxy, alkoxy, or other substituents.A process of preparing such piperidine derivative compounds in substantially pure form is also disclosed.Type: GrantFiled: May 31, 1995Date of Patent: December 3, 1996Assignee: Albany Molecular Research, Inc.Inventor: Thomas E. D'Ambra
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Patent number: 5571940Abstract: In this method, one attaches one or more chelatant molecules to a mono- or polyamino intermediate compound I which is temporarily immobilized on a solid phase by a splittable bond. Thereafter, said bond is split to release the desired conjugate moiety, whereby a reactive site is generated at the splitting site. The conjugate can be coupled to a protein homing factor using said reactive site; the latter being single per chelatant molecule, undesirable cross-linking during conjugation is substantially avoided.Type: GrantFiled: February 3, 1995Date of Patent: November 5, 1996Assignee: Bracco International B.V.Inventor: Paul Palacios
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Patent number: 5442088Abstract: Process for the preparation of phosphorus-containing L-amino acids, their derivatives and intermediates for this processL-amino acids of the formula I and salts thereof, ##STR1## in which R.sup.1 to R.sup.5 are defined as in claim 1 and n is 0 or 1, are obtained according to the invention bya) reacting an optically active S-homoserine lactone of the formula II, ##STR2## with hydrogen chloride in the presence of an alcohol of the formula R.sup.5 --OH to give novel compounds of the formula III, ##STR3## in which R.sup.3, R.sup.4 and R.sup.5 are defined as in formula I, except that R.sup.5 =H, andb) reacting the resulting compound of formula III with a compound of formula IV,R.sup.1 (O).sub.n -R(OR.sup.2).sub.2 (IV)and if desired, hydrolyzing the product to give a compound of formula I, in which R.sup.5 =H.Type: GrantFiled: July 7, 1994Date of Patent: August 15, 1995Assignee: Hoechst AktiengesellschaftInventor: Michael Hoffmann
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Patent number: 5414017Abstract: Compounds of the formula ##STR1## wherein m is zero or 1; n is zero, 1 or 2; p is zero or 1 to 6 provided that m and p are not both zero; R.sub.3 is hydrogen, acyl, or benzyl; and R.sub.1 is hydrogen, alkyl, phenyl, substituted phenyl, phenyl-alkylene, heterocyclic-alkylene, etc. These compounds are useful as cardiovascular agents.Type: GrantFiled: March 26, 1993Date of Patent: May 9, 1995Assignee: E. R. Squibb & Sons, Inc.Inventors: Norma G. Delaney, George C. Rovnyak, Melanie J. Loots
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Patent number: 5298655Abstract: The present invention is directed to farnesyl pyrophosphate analogs which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention, and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.Type: GrantFiled: September 27, 1991Date of Patent: March 29, 1994Assignee: Merck & Co., Inc.Inventors: Neville J. Anthony, Ta-Jyh Lee, Robert L. Smith, Gerald E. Stokker
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Patent number: 5275752Abstract: The corrosive effect of salt on reinforced concrete in roadways, overpasses, bridges and buildings is inhibited by the application of a composition which consists essentially of ammonium carbamate, or which consists essentially of ammonium carbamate combined with salt or calcium chloride, as a deicer.Type: GrantFiled: May 18, 1992Date of Patent: January 4, 1994Inventor: Charles N. Hansen
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Patent number: 5254611Abstract: Urethane oligomers having the formula:H.sub.2 C:CHCOORO[[COHNR'NHCO[O[CH.sub.2 ].sub.t CCH.sub.3 X].sub.m O].sub.n [CONHR'NHCOYR"Y].sub.p ].sub.q CONHR'NHCOOROCOCH:CH.sub.2(I)as well as process therefor are described. These oligomers are photocurable and useful as coatings and ink.Type: GrantFiled: June 30, 1992Date of Patent: October 19, 1993Assignee: Henkel CorporationInventor: Michael D. McDermott
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Patent number: 5247121Abstract: The alkyl esters of N-carboalkyloxy-11-aminoundecanoic acids have the following general formula: ##STR1## wherein R is linear or branched C.sub.7-30 alkyl, linear or branched C.sub.4-22 alkenyl or a radical of formula: ##STR2## wherein n is 0 to 5 R" is linear or branched C.sub.7-30 alkyl, andR' is linear C.sub.10-18 alkyl.These esters, and esters wherein R is additionally hydrogen or C.sub.1-6, have an application as thickening agents in organic media particularly in the cosmetic field.Type: GrantFiled: February 4, 1992Date of Patent: September 21, 1993Assignee: L'OrealInventors: Henri Sebag, Didier Semeria
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Patent number: 5219644Abstract: This invention relates to an article comprising:(A) at least one polymer fabric treated with (B) at least one wetting agent which comprises at least one compound of the formulae ##STR1## wherein each R.sub.1 is independently a hydrocarbyl group having from about 8 to about 150 carbon atoms; each R.sub.2 is independently hydrogen, an alkyl group or polyoxyalkylene group; each R.sub.3 is independently an alkylene group; R.sub.4 is an alkyl group or polyoxyalkylene group; n is 1 to about 150; and M is a hydrogen, an ammonium cation or a metal cation.The treated polymer fabrics of the present invention have improved wicking/wetting characteristics. Further, the fabrics maintain these characteristics upon repeated exposure to fluids.Type: GrantFiled: March 15, 1990Date of Patent: June 15, 1993Inventors: Kasturi Lal, Richard M. Lange
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Patent number: 5209966Abstract: This invention relates to an article comprising:(A) a polymer fabric treated with (B) a wetting agent which comprises at least one compound of the formula ##STR1##wherein R.sub.1 is a hydrocarbyl group having about 8 to about 150 carbon atoms; R.sub.2 is a hydrocarbylene group, or a hydroxy substituted or hydroxyalkyl substituted hydrocarbylene; each R.sub.3 is independently hydrogen, an alkyl group, a hydroxyalkyl group, a hydrocarbylcarbonyl or a polyoxyalkylene group; each R.sub.4 is independently a hydrocarbylene group; each n is independently 1 to 150; m is zero or one; m' is zero or one; M is a hydrogen, an ammonium cation or a metal cation, andwhen m' is zero, X is --H, --Ar, --OH, --OR.sub.5, ##STR2## when m' is one, X is --H, --R.sub.5, ##STR3##wherein each R.sub.5, R.sub.6 and R.sub.8 is independently a hydrocarbyl group having up to 100 carbon atoms; R.sub.7 is hydrogen or an alkyl group having from 1 to about 8 carbon atoms and Ar is a phenyl group.Type: GrantFiled: March 15, 1990Date of Patent: May 11, 1993Assignee: The Lubrizol CorporationInventors: Richard M. Lange, Arturs Grava
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Patent number: 5200551Abstract: The present invention relates to an improved method for the preparation of an intermediate for bambuterol, i.e. for the preparation of 2'-bromo-3,5-di[N,N-dimethylcarbamoyloxy]acetophenone (1), by reacting 3,5-dihydroxyacetophenone with N,N-dimethylcarbamoylchloride in ethyl acetate, isopropylacetate, butylacetate, ethylmethylketone or isobutylmethylketone as a solvent with small amount of pyridine as a catalyst and using crystallized potassium carbonate as a base, quenching with water, removing the solvent and dissolving of the resulting 3,5-di[N,N-dimethylcarbamoyloxy]acetophenone in ethyl acetate, to which dissolved hydrogen bromide is added and then bromine, whereupon the resulting intermediate (1) is collected in the form of crystals.Type: GrantFiled: July 31, 1991Date of Patent: April 6, 1993Assignee: Aktiebolaget AstraInventor: Peter Jaksch