Alpha N, Beta S - Acids Or Salts Thereof Patents (Class 562/557)
  • Patent number: 4176235
    Abstract: New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: December 4, 1978
    Date of Patent: November 27, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Frank L. Weisenborn
  • Patent number: 4169899
    Abstract: Penicillamine compounds of the formula: ##STR1## and of the formula: ##STR2## wherein R.sup.1, R.sup.2, R.sup.3, A and B are as defined hereinafter, and pharmaceutically acceptable acid addition salts thereof are disclosed. II are the products of hydrolysis or alcoholysis of I, and I are in turn the products of dehydration of II or alcohol removal form II. I and II are useful for the treatment of rheumatoid arthritis.
    Type: Grant
    Filed: January 6, 1978
    Date of Patent: October 2, 1979
    Assignee: Yoshitomi Pharmaceutical Industries, Ltd.
    Inventors: Masami Shiroki, Yutaka Maruyama, Kazuhiro Goto
  • Patent number: 4156786
    Abstract: New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: June 26, 1978
    Date of Patent: May 29, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Michael E. Condon
  • Patent number: 4154960
    Abstract: New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: June 29, 1978
    Date of Patent: May 15, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Michael E. Condon
  • Patent number: 4150240
    Abstract: D-Penicillamine and salts thereof may be prepared by reacting certain aryl amines with 4-thiazolidinecarboxylic acid compounds obtained by splitting the .beta.-lactam ring of penicillin derivatives such as benzylpenicillin or phenoxymethylpenicillin.
    Type: Grant
    Filed: July 8, 1977
    Date of Patent: April 17, 1979
    Assignee: Taisho Pharmaceutical Co., Ltd.
    Inventors: Kaoru Sota, Toshihisa Ogawa, Jiro Sawada
  • Patent number: 4140864
    Abstract: New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: March 24, 1978
    Date of Patent: February 20, 1979
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel A. Ondetti, Frank L. Weisenborn
  • Patent number: 4137420
    Abstract: This invention relates to the compounds: N-(mercaptoacy)-cysteine represented by the following formula wherein Z is selected from the group consisting of CH.sub.3 --CH<, (CH.sub.3).sub.2 C<, (CH.sub.2).sub.2 < and CH.sub.
    Type: Grant
    Filed: February 23, 1978
    Date of Patent: January 30, 1979
    Assignee: Santen Pharmaceutical Co., Ltd.
    Inventors: Tadashi Fujita, Masayuki Oya, Hideo Takashina, Tadashi Iso
  • Patent number: 4130713
    Abstract: A novel procedure for the preparation of biotin employing cysteine as the starting material is disclosed. This synthesis involves the formation of the thiophane ring by a 1,3-dipolar addition. By virtue of this process pure d-biotin can be obtained, thus obviating the need for chemical resolution. Novel intermediates are also disclosed.
    Type: Grant
    Filed: August 5, 1977
    Date of Patent: December 19, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Enrico G. Baggiolini, Hsi L. Lee, Milan R. Uskokovic
  • Patent number: 4129593
    Abstract: Very pure S-carboxymethyl-L-cysteine is prepared by reacting L-cystine in liquid ammonia with metallic sodium to form the disodium salt of L-cysteine, evaporating the ammonia, reacting the disodium salt of L-cysteine with an aqueous solution of chloroacetic acid and precipitating the S-carboxymethyl-L-cysteine formed by acidifying the reaction mixture. There is employed 0.1 to 10 weight percent of a reducing agent based on the chloroacetic acid.
    Type: Grant
    Filed: September 14, 1977
    Date of Patent: December 12, 1978
    Assignee: Deutsche Gold- und Silber-Scheideanstalt vormals Roessler
    Inventors: Alfred Maierhofer, Hans Wagner
  • Patent number: 4116962
    Abstract: New substituted acyl derivatives of amino acids which have the general formula ##STR1## are useful as angiotensin converting enzyme inhibitors.
    Type: Grant
    Filed: December 3, 1976
    Date of Patent: September 26, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Miguel Angel Ondetti, Frank Lee Weisenborn
  • Patent number: 4111933
    Abstract: In the process for preparing an organic compound of the formulaA' -- Xin whichX is an amino group, a hydroxyl group or a carboxyl group, andA' is the remainder of the molecule, from an organic compound of the formulaA -- Xin whichA is the remainder of the molecule which can undergo reaction to form A', by converting A -- X into a compound of the formulaA -- Z -- COORin whichZ is --NH--, --O-- or a direct C--C bond, andR is a radical of the formula ##STR1## IN WHICH Y is a direct C--C single bond, the --CH.dbd.CH-- group or an arylene group,R.sup.1 to R.sup.4 each independently is hydrogen, halogen or an alkyl, aryl, aralkyl, alkoxycarbonyl, alkylaminocarbonyl, arylaminocarbonyl or cycloalkylaminocarbonyl radical, orR.sup.1 + r.sup.2 and R.sup.3 + R.sup.4 each independently completes a 5- or 6-membered carbocyclic ring, orR.sup.1 and R.sup.
    Type: Grant
    Filed: April 28, 1977
    Date of Patent: September 5, 1978
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heiner Eckert, Ivar Ugi, Hans-Joachim Kabbe