Carboxylic Halides (i.e., Compounds Having The -c(=o)-halo Group) Patents (Class 562/840)
  • Patent number: 5130454
    Abstract: Polytetrahydrofuran derivatives of the general formula ##STR1## where n is from 2 to 70, X is the bridge member --NH-- or --O-- and R.sup.1 and R.sup.4 are each hydrogen or various radicals.
    Type: Grant
    Filed: December 19, 1990
    Date of Patent: July 14, 1992
    Assignee: BASF Aktiengesellschaft
    Inventors: Eckhard Hickmann, Ulrich Koehler, Hardo Siegel
  • Patent number: 5126482
    Abstract: Novel fluorine-containing compounds and processes for producing the same are disclosed, the compounds being represented by the general formula (I): ##STR1## wherein R.sup.1 represents an alkyl group or an alkylvinyl group; R.sup.2 represents a fluoroalkyl group; and Y represents a carboxyl group, a chloroformyl group, an alkoxyalkoxycarbonyl group or a hydroxymethyl group.
    Type: Grant
    Filed: January 3, 1991
    Date of Patent: June 30, 1992
    Assignee: Nippon Mining Co., Ltd.
    Inventors: Takeshi Nakai, Osamu Takahashi
  • Patent number: 5126462
    Abstract: Aromatic tetracarboxylic acids or derivatives thereof of the general formula I ##STR1## in which R denotes a divalent radical of the formula II ##STR2## Ar denotes tri- or tetravalent aromatic radicals or mixtures thereof, X, if Ar is trivalent, denotes an amide radical, and if Ar is tetravalent denotes an imide radical, and Y and Z either together denote the anhydride radical --CO--O--CO-- or by themselves and independently of one another denote the radicals --COOH, --COCL or --COOR.sub.1, and a process for their preparation.
    Type: Grant
    Filed: June 12, 1990
    Date of Patent: June 30, 1992
    Assignee: Chemie Linz Gesellschaft m.b.H.
    Inventors: Gerd Greber, Heinrich Gruber, Marcel Sychra
  • Patent number: 5117038
    Abstract: Herbicidal substituted phenoxyphenylpropionic acid derivatives of the formula ##STR1## in which Q represents S, SO or SO.sub.2,m represents the numbers 0 or 1,R.sup.1 represents hydrogen, halogen, cyano or trifluoromethyl,R.sup.2 represents hydrogen or halogen,R.sup.3 represents halogen, cyano, trifluoromethyl, trifluoromethoxy or trifluoromethylsulphonyl,R.sup.4 represents hydrogen or halogen,R.sup.5 represents hydrogen or halogen,R.sup.6 represents hydrogen, cyano, carboxyl, alkyl optionally substituted by halogen or alkoxycarbonyl,R.sup.7 represents halogen, hydroxyl, amino, alkylamino, alkenylamino, alkynylamino, arylamino, aralkylamino, alkoxycarbonyl-alkylamino, cyanoamino, dialkylamino, dialkenylamino, alkylsulphonylamino, arylsulphonylamino, hydroxyamino, alkoxyamino, hydrazino, alkylsulphonylhydrazino, arylsulphonylhydrazino, alkylthio, arylthio, aralkylthio, alkoxycarbonylalkylthio or the grouping O--R.sup.8.
    Type: Grant
    Filed: February 16, 1990
    Date of Patent: May 26, 1992
    Assignee: Bayer Aktiengesellschaft
    Inventors: Michael Haug, Albrecht Marhold, Hans-Joachim Santel, Klaus Lurssen, Robert R. Schmidt
  • Patent number: 5110983
    Abstract: Compounds of the formula I ##STR1## can be prepared by various process steps from 2-(4-methylphenyl)-2-hexafluoroisopropanol.Hexafluoroisopropyl-containing monomers are important starting compounds in the preparation of linear polycarboxamides and polycarboximides.
    Type: Grant
    Filed: March 22, 1990
    Date of Patent: May 5, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Jurgen Lau, Gunter Siegemund, Freimund Rohrscheid
  • Patent number: 5101065
    Abstract: A process for the preparation of 2-(hydrogen, halogen or lower alkyl)-3-(hydroxy, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, --OCH.sub.2 CH.sub.2 OCH.sub.3, --OCH.sub.2 CH.sub.2 OC.sub.2 H.sub.5, --OCH.sub.2 CH.sub.2 SCH.sub.3 or --OCH.sub.2 CH.sub.2 SC.sub.2 H.sub.5)-4-(alkythio or alkylsulfonyl)-acetophenones.
    Type: Grant
    Filed: February 4, 1991
    Date of Patent: March 31, 1992
    Assignee: Imperial Chemical Industries plc
    Inventor: Richard W. Brown
  • Patent number: 5098613
    Abstract: This invention provides benzene derivatives, pharmaceutical formulations of those derivatives, and a method of using the derivatives for the treatment of inflammation in mammals.
    Type: Grant
    Filed: July 11, 1990
    Date of Patent: March 24, 1992
    Assignee: Eli Lilly and Company
    Inventors: Nancy G. Bollinger, Theodore Goodson, Jr., David K. Herron
  • Patent number: 5097068
    Abstract: Novel trisubstituted benzoic acid intermediates which are useful in the preparation of certain herbicidal 2-(2,3,4-trisubstituted benzoyl)-1,3-cyclohexandediones. The intermediate benzoic acids of this invention have the following structural formula ##STR1## wherein R.sup.6 is chlorine, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio or hydroxy; n is the integer 0 or 2; and R.sup.7 is C.sub.1 -C.sub.4 alkyl.
    Type: Grant
    Filed: December 7, 1989
    Date of Patent: March 17, 1992
    Assignee: ICI Americas, Inc.
    Inventor: David L. Lee
  • Patent number: 5093522
    Abstract: The present invention relates to new carboxylic acid halides containing trifluoromethyl groups, of the formula (I) ##STR1## in which the symbols used have the meanings given in the description, a process for their preparation by reaction of perhalogenoalkanes with carbon monoxide and an olefin and their use for the preparation of textile auxiliaries.
    Type: Grant
    Filed: September 12, 1990
    Date of Patent: March 3, 1992
    Assignee: Bayer Aktiengesellschaft
    Inventors: Dietmar Bielefeldt, Heinz Ziemann
  • Patent number: 5089485
    Abstract: New furanone compounds have anti-inflammatory, immunosuppressive and anti-proliferative activity and are useful in treating psoriasis and modifying calcium homeostasis. A compound of the invention is 4-(1-thioacetoxytridecyl-5-hydroxy-2(5H)-furanone.
    Type: Grant
    Filed: October 25, 1989
    Date of Patent: February 18, 1992
    Assignee: Allergan, Inc.
    Inventor: Gary C. M. Lee
  • Patent number: 5079384
    Abstract: Herbicidal (6-(hetero(aryloxy-naphthalen-2-yl-oxy)-alkanecarboxylic acid derivatives of the formula ##STR1## in which R.sup.1 stands for hydrogen, halogen, cyano or trifluoromethyl,R.sup.2 stands for hydrogen or halogen,R.sup.3 stands for halogen, trifluoromethyl, trifluomethoxy, trifluoromethylthio or trifluoromethylsulphonyl,R.sup.4 stands for hydrogen or halogen,X stands for nitrogen or the grouping C--R.sup.5 ,in whichR.sup.5 stands for hydrogen or halogen,A stands for optionally branched alkanediyl andZ stands for cyano or the grouping --CO--Y.
    Type: Grant
    Filed: October 27, 1988
    Date of Patent: January 7, 1992
    Assignee: Bayer Aktiengesellschaft
    Inventors: Michael Haug, Roland Andree, Hans-Joachim Santel, Robert R. Schmidt, Harry Strang
  • Patent number: 5075497
    Abstract: Novel trisubstituted benzoic acid intermediates which are useful in the preparation of certain herbicidal 2-(2,3,4-trisubstituted benzoyl)-1,3-cyclohexanediones are described.
    Type: Grant
    Filed: December 10, 1990
    Date of Patent: December 24, 1991
    Assignee: ICI Americas, Inc.
    Inventors: William J. Michaely, Jeff K. Curtis
  • Patent number: 5072038
    Abstract: 2,3,4,5-trihalogenobenzene derivatives of the formula ##STR1## in which R is --COOH, --COCl, --COF, --CN, --CONH.sub.2, --CH.sub.2 OH, --CH.sub.2 Cl, --CHCl.sub.2, --CCl.sub.3 or --CHO,R.sup.1 is H, Cl or F, andR.sup.2 is Cl or F,it only being possible for R.sup.1 or R.sup.2 to be F, and processes for their preparation starting from benzonitriles reacted with potassium fluoride. The novel compounds are intermediates for antibacterials such as quinolone carboxylic acids.
    Type: Grant
    Filed: January 2, 1990
    Date of Patent: December 10, 1991
    Assignee: Bayer Aktiengesellschaft
    Inventors: Erich Klauke, Uwe Petersen, Klaus Grohe
  • Patent number: 5068423
    Abstract: Novel trisubstituted benzoic acid intermediates which are useful in the preparation of certain herbicidal 2-(2,3,4-trisubstituted benzoyl)-1,3-cyclohexanediones are described.
    Type: Grant
    Filed: December 10, 1990
    Date of Patent: November 26, 1991
    Assignee: ICI Americas Inc.
    Inventors: William J. Michaely, Jeff K. Curtis
  • Patent number: 5068394
    Abstract: Herbicidal (hetero)aryloxynaphthalene derivatives of the formula ##STR1## in which X is N or --C--R.sup.5,R.sup.1, R.sup.2, R.sup.4 and R.sup.5 are hydrogen or halogen or R.sup.1 may be cyano or trifluoromethyl,R.sup.3 is halogen, trifluoromethyl, trifluoromethoxy, trifluoromethylthio or trifluoromethylsulphonyl,Y is optionally halogen-substituted alkanediyl or alkenediyl, andZ is CN or --CC--Z', whereZ' is halogen, hydroxyl, amine, alkoxy, or the like.Intermediates of the formula ##STR2## are also new.
    Type: Grant
    Filed: October 19, 1989
    Date of Patent: November 26, 1991
    Assignee: Bayer Aktiengesellschaft
    Inventors: Roland Andree, Michael Haug, Hans-Joachim Santel, Robert R. Schmidt, Harry Strang
  • Patent number: 5043450
    Abstract: Quinolonecarboxylic acid derivatives of the following formula, ##STR1## wherein R indicates a hydrogen atom or lower alkyl group, R.sup.1 indicates a lower alkyl group, R.sup.2 indicates a hydrogen atom, amino group or nitro group, X indicates a halogen atom, and Z indicates a halogen atom, piperazino group, N-methylpiperazino group, 3-methylpiperazino group, 3-hydroxypyrrolidino group, or pyrrolidino group of the following formula, ##STR2## (here, n is 0 or 1, R.sup.3 indicates a hydrogen atom or lower alkyl group, R.sup.4 indicates a hydrogen atom, lower alkyl group or substituted lower alkyl group and R.sup.5 indicates a hydrogen atom, lower alkyl group, acyl group or alkoxycarbonyl group), the hydrates and pharmaceutically acceptable salts thereof are useful as antibacterial agents.
    Type: Grant
    Filed: October 22, 1990
    Date of Patent: August 27, 1991
    Assignee: Kyorin Pharmaceutical Co., Ltd.
    Inventors: Kuniyoshi Masuzawa, Seigo Suzue, Keiji Hirai, Takayoshi Ishizaki
  • Patent number: 5041641
    Abstract: Pentafluorophenyl derivatives are expressed by the formula (I): ##STR1## where X represents an alkyl group having from 1 to 4 carbon atoms or a halogen atom; Y represents any group of --CH.sub.2 OH, --COOH, --COCl, --CON.sup.1 R.sup.2, or --OSO.sub.2 R.sup.3 ; R.sup.1, R.sup.2 and R.sup.3 represent an alkyl group which may have a substituted group, an aryl group which may have a substituted group, or a hydrogen atom except for R.sup.3. However, when X to a halogen atom, Y is the aforementioned groups other than --OSO.sub.2 R.sup.3. A racemate and/or an optical active form of the pentafluorophenyl derivatives can be used suitably as derivatizing agents for electron capture detection and optical resolution for analysis and as intermediates for medicines, agricultural chemicals, functional polymers, etc. The pentafluorophenyl derivatives are produced from pentafluorostyrene oxide.
    Type: Grant
    Filed: April 11, 1989
    Date of Patent: August 20, 1991
    Assignee: Nippon Mining Company Limited
    Inventors: Osamu Takahashi, Keizo Furuhashi, Junko Umezawa
  • Patent number: 5041649
    Abstract: Carbonyl halides I ##STR1## where R.sup.1 is H, alkyl, cycloalkyl, haloalkyl or halocycloalkyl,R.sup.2 and R.sup.3 are each alkyl, cycloalkyl, haloalkyl or halocycloalkyl and may furthermore be bonded to one another to form a 5-membered to 7-membered ring andis halogen,are prepared by reacting an alkyl halide II ##STR2## with carbon monoxide under superatmospheric pressure in the presence of a catalytic amount ofa) aluminum bromide and in the presence or absence of a solvent orb) aluminum chloride or bromide and in the presence of a halohydrocarbon and a carbonyl halide of the formula IIIR.sup.4 --CH.sub.2 --CO--Hal (III)where R.sup.4 is hydrogen or C.sub.1 -C.sub.4 -alkyl and Hal is halogen.
    Type: Grant
    Filed: June 29, 1987
    Date of Patent: August 20, 1991
    Assignee: BASF Aktiengesellschaft
    Inventor: Kaspar Bott
  • Patent number: 5026896
    Abstract: Novel trisubstituted benzoic acid intermediates which are useful in the preparation of certain herbicidal 2-(2,3,4-trisubstituted benzoyl)-1,3-cyclohexanediones are described.
    Type: Grant
    Filed: May 8, 1990
    Date of Patent: June 25, 1991
    Assignee: ICI Americas Inc.
    Inventor: William J. Michaely
  • Patent number: 5013854
    Abstract: An improved process for preparing trialkylsilyl ester and acid halide derivatives of carboxylic acids is provided along with novel trialkylsilyl ester intermediates of 2-(2-furyl)-2-methoximinoacetic acid.
    Type: Grant
    Filed: February 2, 1989
    Date of Patent: May 7, 1991
    Assignee: Eli Lilly and Company
    Inventor: Charles A. Bunnell
  • Patent number: 5002960
    Abstract: Compounds of the formulas: ##STR1## wherein Het is an oxazole or oxazine moiety; X is O, S or SO, n is an integer from 3 to 9, Y is an aliphatic bridge; and the various R groups represent hydrogen or various substituents as described herein, are useful as antiviral agents, especially against picornaviruses. N-(Chloroalkyl)amide intermediates for the compounds of Formula I are also active as antiviral agents. Related compounds outside the scope of the above formulas are also disclosed. Also disclosed are novel intermediates, N-halo-alkyl-4-(isoxazol-5-yl)alkoxybenzamides, also useful as antiviral agents.
    Type: Grant
    Filed: June 12, 1989
    Date of Patent: March 26, 1991
    Assignee: Sterling Drug, Inc.
    Inventor: Guy D. Diana
  • Patent number: 5001256
    Abstract: Novel trisubstituted benzoic acid intermediates which are useful in the preparation of certain herbicidal 2-(2,3,4-trisubstituted benzoyl)-1,3-cyclohexanediones are described.
    Type: Grant
    Filed: July 31, 1989
    Date of Patent: March 19, 1991
    Assignee: ICI Americas Inc.
    Inventors: William J. Michaely, Jeff K. Curtis
  • Patent number: 4996355
    Abstract: The present invention comprises compounds of the formulas: ##STR1## wherein X is Cl or Br. These compounds are useful as intermediaries for the production of 2,4,5-trifluorobenzoic acid and 2,4,5-trifluorobenzoyl fluoride.
    Type: Grant
    Filed: April 14, 1989
    Date of Patent: February 26, 1991
    Assignee: Mallinckrodt, Inc.
    Inventor: Narayanasamy Gurusamy
  • Patent number: 4994574
    Abstract: Preparation of 3-isothiazolones by a single-kettle synthesis from a 3,3'-dithiodipropionic acid, a 3-thiopropionic acid, or their related acid halide by reacting sequentially with a thionyl halide (if the (di)acid halide has not previously been formed), followed by reaction with a halogenating agent, then a primary amine and base, and then with a halogenating agent.
    Type: Grant
    Filed: November 27, 1987
    Date of Patent: February 19, 1991
    Inventor: George M. Lein, Jr.
  • Patent number: 4952708
    Abstract: An improved method for making biaryl compounds is disclosed, in which an aromatic acid halide having at least one strong electron-withdrawing group attached to or within the aromatic ring is reacted with at least one polysilane in the presence of an effective amount of a transition metal catalyst.
    Type: Grant
    Filed: April 3, 1989
    Date of Patent: August 28, 1990
    Assignee: General Electric Company
    Inventors: Jonathan D. Rich, Terry E. Krafft, Philip J. McDermott, Tony C. Chang
  • Patent number: 4938898
    Abstract: The present invention relates to improved processes for selectively chlorinating acyl compounds at the alpha or 2-position. The process of the present invention comprises a method of producing alpha-chloro acyl chlorides comprising contacting an acyl chloride with a chlorine source at a temperature of about 75.degree. C. to about 125.degree. C. in the presence of (i) an effective amount of an auxiliary acidic agent and (ii) an effective amount of a food grade antioxidant and optionally (iii) an effective amount of oxygen or air.
    Type: Grant
    Filed: June 29, 1984
    Date of Patent: July 3, 1990
    Assignee: The Procter & Gamble Company
    Inventor: James E. Thompson
  • Patent number: 4920120
    Abstract: Novel naphthyridine-, and quinolinecarboxylic acids as antibacterial agents are described as well as methods for their manufacture, formulation, and use in treating bacterial infections including the description of certain novel intermediates used in the manufacture of the antibacterial agents.
    Type: Grant
    Filed: December 9, 1988
    Date of Patent: April 24, 1990
    Assignee: Warner-Lambert Company
    Inventors: John M. Domagala, Susan E. Hagen, John S. Kiely
  • Patent number: 4888139
    Abstract: Process for preparing CHF.sub.2 OCHFCF.sub.3 through the use of novel intermediate compounds CHCl.sub.2 OCH.sub.2 COCl and CHCl.sub.2 OCHClCOCl.
    Type: Grant
    Filed: January 25, 1989
    Date of Patent: December 19, 1989
    Assignee: BOC, Inc.
    Inventors: Donald F. Halpern, Mark L. Robin
  • Patent number: 4855511
    Abstract: Process for preparing CHF.sub.2 OCHFCF.sub.3 through the use of novel intermediate compounds CHCl.sub.2 OCH.sub.2 COCl and CHCl.sub.2 OCHClCOCl.
    Type: Grant
    Filed: July 18, 1988
    Date of Patent: August 8, 1989
    Assignee: BOC, Inc.
    Inventors: Donald F. Halpern, Mark L. Robin
  • Patent number: 4849540
    Abstract: Explosive compounds of the formulas ##STR1## where R is --CH.sub.2 C(NO.sub.2).sub.2 CH.sub.3, --CH.sub.2 C(NO.sub.2)b.3 --CH.sub.2 CF(NO.sub.2).sub.2, or --CH.sub.2 CF.sub.2 (NO.sub.2) and R' is --CH.sub.2 CF(NO.sub.2).sub.2 or --CH.sub.2 CF.sub.2 (NO.sub.2); ##STR2## where R is --CH.sub.2 C(NO.sub.2).sub.3 or --CH.sub.2 CF(NO.sub.2).sub.
    Type: Grant
    Filed: June 24, 1988
    Date of Patent: July 18, 1989
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Michael E. Sitzman, William H. Gilligan
  • Patent number: 4845302
    Abstract: 5H-Dibenzo[a,d]cyclohepten-5-ones (I) ##STR1## (A and B being radicals for completing aromatic ring systems) are prepared by converting (Z)-2-(2-arylethenyl)arylcarboxylic acids (II) ##STR2## or E/Z-isomer mixtures thereof with a halogenating agent for carboxylic acids at from (-30.degree.) to +120.degree. C. to the corresponding carbonyl halides (III) ##STR3## where X is halogen, and cyclizing said carbonyl halides at from 0.degree. to 100.degree. C. in the presence of a Lewis acid.
    Type: Grant
    Filed: December 18, 1987
    Date of Patent: July 4, 1989
    Assignee: BASF Aktiengsellschaft
    Inventors: Marco Thyes, Gerd Steiner