Phosphorus Containing Patents (Class 568/8)
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Patent number: 7312251Abstract: Stable rare earth tris (organophosphate) solutions comprise a rare earth tris (organophosphate) and a hydrocarbon solvent. From about 2% to about 10% rare earth element, preferably from about 3% to about 8%, is present in the solutions. The rare earth tris (organophosphate) solutions are stable from precipitation of the rare earth tris (organophosphate) for at least about fifteen (15) days, preferably for at least about twenty (20) days and most preferably at least about thirty (30) days. A process for preparing these solutions is described herein. A stabilizing additive, acid, glycol or mixtures thereof, is utilized to inhibit precipitation. The molar ratios of free acid, glycol and/or water to the rare earth element are controlled to inhibit precipitation.Type: GrantFiled: April 7, 2004Date of Patent: December 25, 2007Assignee: Rhodia Rare Earths, Inc.Inventors: Kenan Yunlu, Min He
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Patent number: 7297807Abstract: The invention relates to intermediate compounds of the formula wherein R1 is H or a protecting group, R2 and R3 each independently represent H, methyl, or a leaving group, provided that at least one, but not both, of R2 and R3 is a leaving group. The intermediate compounds are useful for the synthesis of discodermolide, its derivatives, and related compounds.Type: GrantFiled: May 31, 2006Date of Patent: November 20, 2007Assignee: The Research Foundation of State University of New YorkInventors: Kathlyn Parker, Huanyan Cao
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Publication number: 20070213563Abstract: The invention relates to mixtures composed of monocarboxy-functionalized dialkylphosphinic salts and of further components, which comprise A) from 98 to 100% by weight of monocarboxy-functionalized dialkylphosphinic salts of the formula (I) in which X and Y are different, where X is Ca, Al, or Zn, and Y is methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, phenyl, 2-hydroxyethyl, 2,3-dihydroxypropyl, 2-hydroxypropyl, 3-hydroxypropyl, 4-hydroxybutyl, 3-hydroxybutyl, 2-hydroxybutyl, and/or 6-hydroxyhexyl, allyl and/or glycerol; or X and Y are different and are Mg, Sb, Sn, Ge, Ti, Fe, Zr, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K, H, and/or a protonated nitrogen base; or X and Y are identical or different and each is then Ca, Al, or Zn; R1, R2, R3, R4, R5, R6, and R7 are identical or different and, independently of one another, are H, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, and/or phenyl, and B) from 0 to 2% by weight of halogens, where the entirety of the components aType: ApplicationFiled: March 6, 2007Publication date: September 13, 2007Inventors: Wiebke Maas, Werner Krause, Harald Bauer
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Patent number: 7256314Abstract: This invention provides a method for generating secondary phosphines from secondary phosphine oxides in the presence of a reducing agent, such as diisobutylaluminum hydride (DIBAL-H), triisobutyldialuminoxane, triisobutylaluminum, tetraisobutyldialuminoxane, or another reducing agent comprising: (i) an R1R2AlH moiety, wherein R1 and R2 are each an alkyl species or oxygen, and wherein at least one of R1 or R2 comprises at least 2 carbon atoms, or (ii) an R1R2R3Al moiety, wherein R1, R2, and R3 are not hydrogen, and wherein at least one of R1, R2, and R3 is an alkyl species comprising a ?-hydrogen, not including triethylaluminum. Preferred reducing agents for the present invention include: diisobutylaluminum hydride, triisobutyldialiuminoxane, triisobutylaluminum, tetraisobutyldialuminoxane, and combinations thereof.Type: GrantFiled: January 12, 2005Date of Patent: August 14, 2007Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Carl Alan Busacca, Jon C. Lorenz
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Patent number: 7238841Abstract: Novel phosphine and phosphine oxide ligands are prepared using polymeric supports. These compounds can be easily cleaved from the support, and along with the corresponding supported compounds, used as ligands in the preparation of novel, metal-complexed catalysts.Type: GrantFiled: May 30, 2003Date of Patent: July 3, 2007Assignee: E. I. du Pont de Nemours and CompanyInventors: Paul J. Fagan, George Yanwu Li
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Patent number: 7230136Abstract: The invention relates to a process for synthesizing tertiary phosphines by reacting halophosphines with organomagnesium compounds in the presence of copper compounds and optionally of salts.Type: GrantFiled: April 17, 2003Date of Patent: June 12, 2007Assignee: LANXESS Deutschland GmbHInventors: Florian Rampf, Hans-Christian Militzer
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Patent number: 7227041Abstract: The present invention is generally directed to electroluminescent Ir(III) compounds with phosphinoalkoxides and phenylpyridines or phenylpyrimidines, and devices that are made with the Ir(III) compounds.Type: GrantFiled: April 13, 2005Date of Patent: June 5, 2007Assignee: E. I. du Pont de Nemours and CompanyInventors: Vladimir Grushin, Viacheslav A. Petrov
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Patent number: 7214830Abstract: A description is given of processes for the preparation of mono- and bisacylphosphines and of mono- and bisacylphosphine oxides and mono- and bisacylphosphine sulfides, which comprises first reacting organic P-monohalogenophosphines or P,P-dihalogenophosphines, or mixtures thereof, with an alkali metal or magnesium in combination with lithium, where appropriate in the presence of a catalyst, and then carrying out the reaction with acid halides and, in the case of the process for the preparation of oxides, carrying out an oxidation step and, in the case of the preparation of sulfides, reacting the phosphines so obtained with sulfur. It is characteristic, inter alia, that the processes are carried out without isolation of the intermediates.Type: GrantFiled: February 6, 2006Date of Patent: May 8, 2007Assignee: Ciba Specialty Chemicals CorporationInventors: David George Leppard, Eugen Eichenberger, René Kaeser, Gebhard Hug, Urs Schwendimann
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Patent number: 7211603Abstract: The invention provides novel tetradentate enediyne ligands that are themselves thermally stable, yet react at about room temperature or slightly higher upon addition of metal ions or under photothermal conditions. In another aspect of the invention, a method of treating a disorder in a mammal comprising administering a therapeutically effective amount of a compound or composition is provided. In addition, the free ligand can be delivered to the mammal prior to complexation to metals, such that the ligand is exposed to a metal in the body and forms a metal complex in vivo. Furthermore, a metal complex of the invention can be administered to the mammal such that the complex exchanges the first metal center with another endogenous metal in order to form a second metal complex in vivo. The second metal complex is capable of forming a benzenoid diradical under physiological conditions and/or under photothermal conditions.Type: GrantFiled: September 29, 2005Date of Patent: May 1, 2007Assignee: Indiana University Research and Technology CorporationInventors: Jeffrey M. Zaleski, Diwan Singh Rawat
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Patent number: 7208626Abstract: The invention relates to a method for producing perfluoroalkyl phosphines, comprising at least one step in which at least one fluoro(perfluoroalkyl)phosphorane is reacted with at least one hydride ion donator, and the use of tris(perfluoroalkyl)phos-phines as perfluoroalkylating reactants.Type: GrantFiled: March 17, 2003Date of Patent: April 24, 2007Assignee: Merck Patent GesellschaftInventors: Urs Welz-Biermann, Nikolai Ignatyev, Michael Weiden, Michael Schmidt, Udo Heider, Alexej Miller, Helge Willner, Peter Sartori
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Patent number: 7196227Abstract: Disclosed is a process for the recovery of phosphorus and/or iodine containing catalyst components, present as an organophosphorus compound such as trihydrocarbylphosphine compounds and tetrahydrocarbylphosphonium compounds, from a solution of at least one such organophosphorus compound in an organic solvent by the steps comprising (1) converting the organophosphorus compound to an iodide complex of a organophosphonium compound which is insoluble in the organic solvent; and (2) separating the insoluble iodide complex of the organophosphonium compound from the solution. The process also results in the recovery of iodine values present in the solution.Type: GrantFiled: December 18, 2003Date of Patent: March 27, 2007Assignee: Eastman Chemical CompanyInventors: Jeffrey Scott Kanel, Stanley John Okrasinski
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Patent number: 7169953Abstract: Chiral ligands and metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The metal complexes according to the present invention are useful as catalysts in asymmetric reactions, such as, hydrogenation, hydride transfer, allylic alkylation, hydrosilylation, hydroboration, hydrovinylation, hydroformylation, olefin metathesis, hydrocarboxylation, isomerization, cyclopropanation, Diels-Alder reaction, Heck reaction, isomerization, Aldol reaction, Michael addition; epoxidation, kinetic resolution and [m+n] cycloaddition. Processes for the preparation of the ligands are also described.Type: GrantFiled: May 28, 2004Date of Patent: January 30, 2007Assignee: The Penn State Research FoundationInventors: Xumu Zhang, Wenjun Tang
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Patent number: 7129367Abstract: Palladum-phosphine complexes obtained by reacting a 5 compound of formula (1) below with a palladium compound: F(I) (wherein R1 is a hydrogen atom, an alkyl group, a cycloalkyl group or a phenyl group which may be substituted; R2 and R3 are each, the same or different, an alkyl group, a cycloalkyl group or a phenyl group which may be substituted; R4 and R5 are each, the same or different, a hydrogen atom, an alkyl group, a cycloalkyl group or a phenyl group which may be substituted; R6, R7, R8 and R9 are each, the same or different, an alkyl group, a cycloalkyl group, a phenyl group which may be substituted, an alkoxyl group, a dialkylamino group, a halogen atom, a phenyl group, a benzyl group, a naphthyl group or a halogenated alkyl group; R6 and R7, R8 and R9 may be combined to form, each, a fused ring, a trimethylene group, a tetramethylene group or a 20 methylenedioxy group; p, q, r and s are each an integer of 0 to 5; and p+q, and r+s are each in the range of 0 to 5.Type: GrantFiled: February 12, 2004Date of Patent: October 31, 2006Assignee: Takasago International CorporationInventors: Ken Suzuki, Yoji Hori
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Patent number: 7122703Abstract: The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between the two reactive partners resulting in a final product comprising a phosphine moiety, or which can be engineered to comprise a cleavable linker so that a substituent of the phosphine is transferred to the azide, releasing an oxidized phosphine byproduct and producing a native amide bond in the final product. The selectivity of the reaction and its compatibility with aqueous environments provides for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).Type: GrantFiled: March 6, 2003Date of Patent: October 17, 2006Assignee: The Regents of the University of CaliforniaInventors: Eliana Saxon, Carolyn Bertozzi
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Patent number: 7112696Abstract: The present invention relates to a process for preparing phosphorus compounds and intermediates.Type: GrantFiled: May 5, 2004Date of Patent: September 26, 2006Assignee: Bayer Chemicals AGInventors: Hansjörg Grützmacher, Elisabetta Piras
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Patent number: 7105702Abstract: Chiral ligands and metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The metal complexes according to the present invention are useful as catalysts in asymmetric reactions, such as, hydrogenation, hydride transfer, allylic alkylation, hydrosilylation, hydroboration, hydrovinylation, hydroformylation, olefin metathesis, hydrocarboxylation, isomerization, cyclopropanation, Diels-Alder reaction, Heck reaction, isomerization, Aldol reaction, Michael addition; epoxidation, kinetic resolution and [m+n] cycloaddition. Processes for the preparation of the ligands are also described.Type: GrantFiled: November 8, 2002Date of Patent: September 12, 2006Assignee: The Penn State Research FoundationInventors: Xumu Zhang, Wenjun Tang
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Patent number: 7105703Abstract: A novel chemical compound has a general formula (LX)nY wherein X is selected from a group consisting of a group 13 element other than boron, Y is selected from a group consisting of a halide, a chlorate, a sulfate and a nitrate and L is a chelating ligand containing two nitrogen and two oxygen donor groups where n=1 or 2.Type: GrantFiled: June 23, 2005Date of Patent: September 12, 2006Assignee: University of Kentucky Research FoundationInventor: David A. Atwood
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Patent number: 7105714Abstract: The present invention provides a method of preparing a phosphonium salt of the formula [R1R2R3P—CR4R5R6]X, comprising ball-milling a phosphine of the formula R1R2R3P with a compound of the formula XCR4R5R6; a method of preparing a phosphorus ylide of the formula R1R2R3P?CR4R5, comprising ball-milling a phosphonium salt of the formula [R1R2R3P—HCR4R5]X in the presence of a base; and a method of preparing an olefin of the formula R4R5C?CR7H or R4R5C?CR7R8, comprising ball-milling a phosphorus ylide of the formula R1R2R3P?CR4R5 with a compound of the formula R7C(O)H or R7C(O)R8. The inventive method produces phosphonium salts and phosphorus ylides by mechanical processing solid reagents under solvent-free conditions.Type: GrantFiled: December 22, 2003Date of Patent: September 12, 2006Assignee: Iowa State University Research Foundation, Inc.Inventors: Vitalij K Pecharsky, Viktor P Balema, Jerzy W Wiench, Marek Pruski
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Patent number: 7094557Abstract: A pharmaceutically acceptable salt of 2-methyl-3-butenyl-l-pyrophosphoric acid; an agent for treating lymphocytes which comprises at least one of 2-methyl-3-butenyl-l-pyrophosphoric acid, a pharmaceutically acceptable salt thereof, and a hydrate thereof; V?2V?2 type T cells treated by the same; and a medicine containing the same specifically stimulate and proliferate the human V?2V?2 type T cells, and also induce and enhance an antitumor activity thereof.Type: GrantFiled: February 25, 2003Date of Patent: August 22, 2006Assignee: Chugai Seiyaku Kabushiki KaishaInventors: Yoshimasa Tanaka, Takehiko Uchiyama
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Patent number: 7074737Abstract: A process for the alkylation of triphenylphosphate by reaction of triphenylphosphate with an olefin in the presence of an effective amount of a solid acid catalyst selected from the group consisting of at least one zeolite, heteropolyacid or salt thereof, metal triflate, non-aryl group-containing metal sulfonic acid, metal halide Lewis acid, or compatible mixture of any such catalyst.Type: GrantFiled: December 23, 2003Date of Patent: July 11, 2006Assignee: Supresta U.S. LLCInventors: Alan J. Abramson, Anantha Desikan, Shuguang Zhang, Zongchao Zhang, James Liang
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Patent number: 7067701Abstract: This invention relates to processes for making phosphorus compounds R2P—X—PR2, R2P-M, R2P-L and R3P, and the novel cation R2P+(L)-X—P+(L)R2, where R represents an optionally substituted hydrocarbyl group, X represents a bridging group, L represents a leaving group and M represents an alkali metal atom. The invention relates further to a process for making a compound R2P-L from a compound R—H via a new process for making the compound R—Li followed by its reaction with a compound Hal2P-L. The compound R2P—X—PR2 is a ligand suitable for making catalysts for copolymerizing carbon monoxide and a olefinically unsaturated compound.Type: GrantFiled: January 15, 2004Date of Patent: June 27, 2006Assignee: SRI InternationalInventors: Roelof Van Ginkel, Alexander Van Der Made, Jan De With, Ursula Eilenberg-Robben, legal representative, Wolf Eilenberg, deceased
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Patent number: 7025904Abstract: Flexible and semi-rigid vinyl chloride resin compositions comprising a combination of a latent mercaptan and a zinc salt of oxidized polyethylene (a zinc ionomer) as a heat stabilizer are substantially free from the offensive odor typically associated with mercaptans and are protected during processing by the degradation products of the latent mercaptan and the zinc ionomer. The oxidized polyethylene is split out from the ionomer to act as an adhesion promoter for aqueous inks and paints, and the residual zinc carboxylate functions as a co-stabilizer with the latent mercaptan in the composition. The latent mercaptan is exemplified by a 2-S-(tetrahydropyranyl)thioalkanol, a carboxylic acid ester thereof, a 2-S-(tetrahydropyranyl)-thiocarboxylic acid, an ester thereof, and the furanyl homologs of each.Type: GrantFiled: September 4, 2003Date of Patent: April 11, 2006Assignee: Rohm and Haas CompanyInventors: Tod C. Duvall, Jeffery L. Carpenter
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Patent number: 6987132Abstract: The invention provides novel tetradentate enediyne ligands that are themselves thermally stable, yet react at about room temperature or slightly higher upon addition of metal ions or under photothermal conditions. In another aspect of the invention, a method of treating a disorder in a mammal comprising administering a therapeutically effective amount of a compound or composition is provided. In addition, the free ligand can be delivered to the mammal prior to complexation to metals, such that the ligand is exposed to a metal in the body and forms a metal complex in vivo. Furthermore, a metal complex of the invention can be administered to the mammal such that the complex exchanges the first metal center with another endogenous metal in order to form a second metal complex in vivo. The second metal complex is capable of forming a benzenoid diradical under physiological conditions and/or under photothermal conditions.Type: GrantFiled: October 10, 2002Date of Patent: January 17, 2006Assignee: Advanced Research and Technology Institute, Inc.Inventors: Jeffrey M. Zaleski, Diwan Singh Rawat
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Patent number: 6969733Abstract: Compounds of the formula I (I), in which Ar is a group or unsubstituted or substituted cyclopentyl, cyclohexyl, naphthyl, biphenylyl or an O-, S- or N-containing 5- or 6-membered heterocyclic ring; R1 and R2 are C1-C20alkyl, OR11, CF3 or halogen; R3, R4 and R5 are hydrogen, C1-C20alkyl, OR11 or halogen; R6 is unsubstituted or substituted C1-C24alkyl, C2-C24alkyl, which is interrupted by O, S or NR14 and is unsubstituted or substituted; C2-C24alkenyl, uninterrupted or interrupted by O, S or NR14 and unsubstituted or substituted; unsubstituted or substituted C7-C24arylalkyl; C4-C24cycloalkyl, uninterrupted or interrupted by O, S and/or NR14; or C8-C24arylcycloalkyl; R11 is C1-C20alkyl, C3-C8cycloalkyl, phenyl, benzyl or C2-C20alkyl, interrupted by O or S and unsubstituted or substituted; R12 and R13 are hydrogen, C1-C20alkyl, C3-C8cycloalkyl, phenyl, benzyl or C2-C20alkyl, interrupted by O atoms and unsubstituted or substituted; or R12 and R13 together are C3-C5alkylene, uninterrupted or interrupted byType: GrantFiled: October 25, 2002Date of Patent: November 29, 2005Assignee: Ciba Specialty Chemicals CorporationInventors: Jean-Pierre Wolf, Gebhard Hug
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Patent number: 6956127Abstract: Disclosed are methods of preparing monoalkyl Group VA metal dihalide compounds in high yield and high purity by the reaction of a Group VA metal trihalide with an organo lithium reagent or a compound of the formula RnM1X3?n, where R is an alkyl, M1 is a Group IIIA metal, X is a halogen and n is an integer fro 1 to 3. Such monoalkyl Group VA metal dihalide compounds are substantially free of oxygenated impurities, ethereal solvents and metallic impurities. Monoalkyl Group VA metal dihydride compounds can be easily produced in high yield and high purity by reducing such monoalkyl Group VA metal dihalide compounds.Type: GrantFiled: January 17, 2003Date of Patent: October 18, 2005Assignee: Shipley Company, L.L.C.Inventors: Deodatta Vinayak Shenai-Khatkhate, Michael Brendan Power, Artashes Amamchyan, Ronald L. DiCarlo, Jr.
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Patent number: 6946578Abstract: An improved phenoxyphosphazene compound is produced by treating a phenoxyphosphazene compound with (a) at least one adsorbent selected from activated carbon, silica gel, activated alumina, activated clay, synthetic zeolite and macromolecular adsorbents, (b) at least one reagent selected from metal hydrides, hydrazine, hypochlorites, thiosulfates, dialkyl sulfuric acids, ortho esters, diazoalkanes, lactones, alkanesultones, epoxy compounds and hydrogen peroxide, or (c) both the adsorbent and reagent, thereby reducing the acid value of said phosphazene compound to lower than 0.025 mgKOH/g.Type: GrantFiled: December 23, 2003Date of Patent: September 20, 2005Assignee: Otsuka Chemical Co., Ltd.Inventors: Shinji Nakano, Yuji Tada, Tadao Yabuhara, Takashi Kameshima, Yoichi Nishioka, Hiroyuki Takase
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Patent number: 6939983Abstract: A method of preparing Group VA organometal compounds in high yield and high purity by the reaction of a Grignard reagent with a Group VA metal halide in certain ethereal solvents is provided. A method of preparing Group VA organometal hydrides is also provided.Type: GrantFiled: May 7, 2004Date of Patent: September 6, 2005Assignee: Rohm and Haas Electronic Materials, LLCInventors: Deodatta Vinayak Shenai-Khatkhate, Artashes Amamchyan, Michael Brendan Power, Ronald L. DiCarol, Jr., James Edward Felton
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Patent number: 6927212Abstract: Aminophosphinic acid derivatives were synthesized as potential inhibitors of renal dipeptidase, an enzyme overexpressed in benign and malignant colon tumors. Several compounds showed potent enzyme-inhibitory activity. These compounds can be used therapeutically and diagnostically for treatment and detection of tumors.Type: GrantFiled: July 28, 2003Date of Patent: August 9, 2005Assignee: The Johns Hopkins UniversityInventors: Saeed R. Khan, Bert Vogelstein, Kenneth W. Kinzler, Hallur Gurulingappa, Phillip Buckhaults
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Patent number: 6914161Abstract: Multidentate phosphate compounds of formula (1) are prepared by reacting a 9-phosphabicyclononane, in the presence of an acid catalyst, with a 9-phospha-bicyclononane alkenylmonophosphine of formula (2), some of which, e.g., P-{2-(2-butenyl)}-9-phospha-bicyclononane, are novel compounds. The multidentate phosphine compounds of formula (1) and those of formula (3), are useful as ligands for transition metal catalysts in various types of reactions, such as, hydrogenation reactions.Type: GrantFiled: May 1, 2002Date of Patent: July 5, 2005Assignee: DSM IP Assets B.V.Inventors: Felix Hugo Beijer, Edwin Gerard Ljpeij
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Patent number: 6867330Abstract: Halogenated phosphines are produced by reacting a secondary phosphine with a quaternary phosphonium halide, in a solvent/carrier for the reactants.Type: GrantFiled: February 27, 2002Date of Patent: March 15, 2005Assignee: Rhodia Consumer Specialties LimitedInventors: Gordon Findlay Docherty, Floryan De Campo
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Patent number: 6855849Abstract: Non-C2-symmetric bisphospholane ligands and methods for their preparation are described. Use of metal/non-C2-symmetric bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.Type: GrantFiled: September 18, 2002Date of Patent: February 15, 2005Assignee: Warner-Lambert CompanyInventors: Garrett Stewart Hoge, II, Om Prakash Goel
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Ortho substituted chiral phosphines and phosphinites and their use in asymmetric catalytic reactions
Patent number: 6855657Abstract: 3,3?-Substituted chiral biaryl phosphine and phosphinite ligands and metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The metal complexes are useful as catalysts in asymmetric reactions, such as, hydrogenation, hydride transfer, allylic alkylation, hydrosilylation, hydroboration, hydrovinylation, hydroformylation, olefin metathesis, hydrocarboxylation, isomerization, cyclopropanation, Diels-Alder reaction, Heck reaction, isomerization, Aldol reaction, Michael addition, epoxidation, kinetic resolution and [m+n] cycloaddition. The metal complexes are particularly effective in Ru-catalyzed asymmetric hydrogenation of beta-ketoesters to beta-hydroxyesters and Ru-catalyzed asymmetric hydrogenation of enamides to beta amino acids.Type: GrantFiled: September 11, 2003Date of Patent: February 15, 2005Assignee: The Penn State Research FoundationInventor: Xumu Zhang -
Patent number: 6852843Abstract: The present invention relates to novel complexes of (transition) metals containing ligands having phosphorus centers supporting a carbene atom or heteroalkane radical bonded to the (transition) metal.Type: GrantFiled: February 3, 2003Date of Patent: February 8, 2005Assignee: The Governors of the University of AlbertaInventors: Ronald G. Cavell, Ruppa P. Kamalesh Babu, Aparna Kasani
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Patent number: 6849669Abstract: The invention relates to macromolecular hydrophilic photocrosslinkers having polymeric backbones of substituted ethylene groups carrying photoactive groups. The photocrosslinkers are capable of producing, when being exposed to light of determined wavelengths above 305 nm, radicals which are retained on the macromolecular photocrosslinkers and reacting so as to accomplish a crosslinked network structure. The invention further relates to the preparation of photocrosslinkers, their use in different aqueous systems and their utility in production of medical devices including ophthalmic lenses.Type: GrantFiled: March 16, 2000Date of Patent: February 1, 2005Assignee: Pharmacia Groningen BVInventors: Kenneth A. Hodd, Keith Alfred Dillingham, Jacqueline deGroot, Hendrik Haitjema
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Patent number: 6815558Abstract: The invention relates to a process for the preparation of (metal) salts of alkylphosphonous acids, which comprises reacting elemental yellow phosphorus with alkyl halides in the presence of carbonates, bicarbonates, amides, alkoxides, amine bases and/or solid hydroxides as bases. The invention also relates to the use of the (metal) salts of alkylphosphonous acids prepared by this process.Type: GrantFiled: May 25, 2000Date of Patent: November 9, 2004Assignee: Clariant GmbHInventor: Norbert Weferling
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Patent number: 6812224Abstract: Use of phosphorous organic compounds of general formula (I) wherein B represents either an ether group of the formula (II) or a keto group of the formula (III) or is a 5 or 6 membered cyclic compound, and their use for preparing pharmaceutical compositions for the therapeutic and prophylactic treatment of infections in humans and animals due to viruses, bacteria, fungi, and parasites as well as their use as a fungicide, bactericide and herbicide in plants.Type: GrantFiled: September 11, 2002Date of Patent: November 2, 2004Assignee: Jomaa Pharmaka GmbHInventor: Hassan Jomaa
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Patent number: 6806378Abstract: The present invention provides a catalyst system and a process for the preparation of a nonracemic chiral alcohol by hydrogenation of a ketone using the catalyst system, wherein the catalyst system comprises ruthenium, a nonracemic chiral diphosphine ligand, an amino-thioether ligand, and a base.Type: GrantFiled: May 21, 2002Date of Patent: October 19, 2004Assignee: DSM N.V.Inventors: Charles E. Tucker, Qiongzhong Jiang
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Patent number: 6806383Abstract: The invention relates to a process for the preparation of (metal) salts of alkylphosphonous acids, which comprises reacting elemental yellow phosphorus with halogen-free alkylating agents in the presence of at least one base. The invention also relates to the use of the (metal) salts of alkylphosphonous acids prepared by this process.Type: GrantFiled: May 25, 2000Date of Patent: October 19, 2004Assignee: Clariant GmbHInventors: Norbert Weferling, Martin Sicken
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Patent number: 6794525Abstract: An (R) or (S) chiral diphosphine of formula (I): wherein R and R1, which can be identical or different, represent an optionally saturated C1-10 alkyl group, an optionally saturated C3-9 cycloalkyl group, a C5-10 aryl group, the groups being optionally substituted by a halogen, a hydroxy, a C1-5 alkoxy, an amino, a sulfino, a sulonfyl, with R4 representing an alkyl, an alkoxy or an alkylcarbonyl, the alkyl, cycloalkyl, aryl groups optionally including one or more heteroatoms, or R and R1 together represent an optionally saturated C2-6 substituted alkyl group, an optionally saturated C3-9 cycloalkyl group, a C5-10 aryl group, the cycloalkyl or aryl groups being optionally substituted by a C1-5 alkyl, a halogen, a hydroxy, a C1-5 alkoxy, an amino, a sulfino, a sulonfyl, with R4 representing an alkyl, an alkoxy or an alkylcarbonyl, the alkyl, cycloalkyl, aryl groups optionally including one or more heteroatoms, R2 and R3, which can be identical or different, represent an optionally saturated C3-Type: GrantFiled: January 31, 2003Date of Patent: September 21, 2004Assignee: PPG-SIPSYInventors: Michel Bulliard, Blandine Laboue, Sonia Roussiasse
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Patent number: 6770779Abstract: The present invention relates to a process for the preparation of alkylphosphonous acid esters which comprises a) reacting elemental yellow phosphorus with alkylating agents in the presence of a base to give a mixture which comprises, as principal constituents, the (metal) salts of alkylphosphonous, phosphorous and hypophosphorous acids, b) esterifying the principal constituents of the mixture from a) to give an ester mixture, c) isolating the ester of the alkylphosphonous acid from the ester mixture. The invention likewise relates to the use of the alkylphosphonous acid esters prepared by this process as precursors for further syntheses, inter alia for the preparation of crop protection agents.Type: GrantFiled: May 24, 2000Date of Patent: August 3, 2004Assignee: Clariant GmbHInventors: Norbert Weferling, Martin Sicken, Hans-Peter Schmitz, Günter Kolbe
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Patent number: 6767927Abstract: Stable rare earth tris (organophosphate) solutions comprise a rare earth tris (organophosphate) and a hydrocarbon solvent. From about 2% to about 10% rare earth element, preferably from about 3% to about 8%, is present in the solutions. The rare earth tris (organophosphate) solutions are stable from precipitation of the rare earth tris (organophosphate) for at least about fifteen (15) days, preferably for at least about twenty (20) days and most preferably at least about thirty (30) days. A process for preparing these solutions is described herein. A stabilizing additive, acid, glycol or mixtures thereof, is utilized to inhibit precipitation. The molar ratios of free acid, glycol and/or water to the rare earth element are controlled to inhibit precipitation.Type: GrantFiled: April 25, 2000Date of Patent: July 27, 2004Assignee: Rhodia Rare Earths Inc.Inventors: Kenan Yunlu, Min He
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Publication number: 20040122229Abstract: The present inventions relate to novel ionic liquids comprising a Lewis acid anion such as AlyR3y+1 wherein y is greater than 0 and R is independently selected from the group consisting of an alkyl group and halogen group. The cation of the ionic liquids can be selected from ammonium, sulfonium, and phosphonium cations wherein said cation generally has less than 14 total carbon atoms. The anion may contain an organic bridge to bond neighboring aluminum atoms that would otherwise be susceptible to leaching aluminum trichloride. The ionic liquids are useful in many applications and particularly as catalysts.Type: ApplicationFiled: August 15, 2003Publication date: June 24, 2004Inventor: Roger Moulton
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Electrochemically stable onium salts and electrolytes containing such for electrochemical capacitors
Patent number: 6743947Abstract: Based on the discovery that the melting point and solubility of onium salts are affected by the asymmetry of the substitution on cation, and that the branched substituents effectively shield onium cations from electrochemical reduction, new onium salts are synthesized and high performance electrolytes based on these salts for electrochemical capacitor are provided. The composition of the new electrolyte comprises an onium salt or mixture of such onium salts dissolved in aprotic, non-aqueous solvents or mixture of such solvents. The electrolyte is able to perform at high rate of charge/discharge, at low ambient temperatures, and within wide operating voltage, due to the high solubility, low melting temperature, and the improved reduction stability of the new onium cations, respectively.Type: GrantFiled: May 10, 1999Date of Patent: June 1, 2004Assignee: The United States of America as represented by the Secretary of the ArmyInventors: Kang Xu, Shengping Ding, T. Richard Jow -
Patent number: 6730812Abstract: The present invention provides a method of preparing a phosphonium salt of the formula [R1R2R3P—CR4R5R6]X, comprising ball-milling a phosphine of the formula R1R2R3P with a compound of the formula XCR4R5R6; a method of preparing a phosphorus ylide of the formula R1R2R3P═CR4R5, comprising ball-milling a phosphonium salt of the formula [R1R2R3P—HCR4R5]X in the presence of a base; and a method of preparing an olefin of the formula R4R5C═CR7H or R4R5C═CR7R8, comprising ball-milling a phosphorus ylide of the formula R1R2R3P═CR4R5 with a compound of the formula R7C(O)H or R7C(O)R8. The inventive method produces phosphonium salts and phosphorus ylides by mechanical processing solid reagents under solvent-free conditions.Type: GrantFiled: February 5, 2003Date of Patent: May 4, 2004Assignee: Iowa State University Research Foundation, Inc.Inventors: Vitalij K. Pecharsky, Viktor P. Balema, Jerzy W. Wiench, Marek Pruski
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Publication number: 20040077754Abstract: Acrylic ester phosphonic acids of general formula (I), stereoisomers thereof and mixtures of these, 1Type: ApplicationFiled: June 25, 2003Publication date: April 22, 2004Inventors: Norbert Moszner, Ulrich Salz, Frank Zeuner, Jorg Zimmermann, Volker Rheinberger, Jorg Angermann, Urs Karl Fischer
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Patent number: 6716825Abstract: The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorder, e.g., osteoporosis and other disorders of bone metabolisum, cancer, viral infections, and the like.Type: GrantFiled: November 6, 2002Date of Patent: April 6, 2004Assignee: The Regents of the University of CaliforniaInventors: Karl Y. Hostetler, James R. Beadle, Ganesh D. Kini
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Patent number: 6713642Abstract: The invention relates to a method for producing compounds of general formula (A) by reacting an alkali metal hydride with a compound (B) during which the reaction is carried out in the presence of a catalyst that contains boron, whereby: M represents Li, Na, K, Rb or Cs; E represents B or Al, and; X1, X2, X3, independent of one another, represent a secondary or tertiary alkyl group, which is comprised of 2 to 10 atoms, or represent a phenyl group which itself can be alkyl-substituted or they represent an alkoxy group, and the catalyst, which contains boron, or the conversion product thereof with MH is capable of acting as a hydride transfer agent.Type: GrantFiled: February 25, 2003Date of Patent: March 30, 2004Assignee: Chemetall GmbHInventors: Ulrich Wietelmann, Dieter Hauk, Andre Majdalani, Uwe Lischka
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Patent number: 6689915Abstract: Non-C2-symmetric bisphospholane ligands and methods for their preparation are described. Use of metal/non-C2-symmetric bisphospholane complexes to catalyze asymmetric transformation reactions to provide high enantiomeric excesses of formed compounds is also described.Type: GrantFiled: February 27, 2002Date of Patent: February 10, 2004Assignee: Warner-Lambert Company LLCInventors: Garrett Stewart Hoge, II, Om Prakash Goel
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Publication number: 20040024255Abstract: The present invention discloses an active-hydrogen-containing curing agent having a phosphorus group, and a flame retardant cured epoxy resin which can be prepared via an addition reaction between the active hydrogen and the epoxide group of an epoxy resin. The cured flame retardant epoxy resin is environmentally friendly and is suitable for printed circuit board and semiconductor encapsulation applications.Type: ApplicationFiled: July 14, 2003Publication date: February 5, 2004Applicant: National Science CouncilInventors: Chun-Shan Wang, Jeng-Yueh Shieh
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Patent number: 6677462Abstract: This invention relates to preparation of enantio-enriched compounds, and more particularly to enantio-enriched kavalactone compounds and derivatives thereof. The methods provide compounds that are useful as reagents, or building blocks, in the construction of other enantio-enriched compounds.Type: GrantFiled: August 6, 2001Date of Patent: January 13, 2004Assignee: Kava Pharmaceuticals, Inc.Inventors: Shoujun Chen, Lijun Sun, Joel McCleary