Glucose Patents (Class 600/319)
  • Patent number: 10478104
    Abstract: A contact lens includes a glucose sensor which can determine when a detectable concentration of glucose is present in the optical fluids of the user. The glucose sensor can transition between a first state and a second state relative to the concentration of glucose within the optical fluid of the user. The glucose sensor can be bonded or otherwise attached or incorporated into the contact lens. While the contact lens is worn in the user's eye, either the user or another person can view the contact lens to quickly determine if an excessive amount of glucose is present in the user's system.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: November 19, 2019
    Assignee: MENICON CO., LTD.
    Inventor: Mouad Lamrani
  • Patent number: 10429169
    Abstract: A physical parameter estimating method, a physical parameter estimating device, and electronic apparatus are disclosed. The method includes: reading a Newton's rings fringe pattern of a unit to be measured; calculating a magnitude spectrum of an intensity distribution signal of at least one first-direction pixel set in the Newton's rings fringe pattern under each fractional Fourier transform (FRFT) order in a searching range of FRFT orders; determining a matched order of the intensity distribution signal according to the calculated magnitude spectrums; and estimating a physical parameter involved in the interferometric measurement according to at least the matched order. Therefore, physical parameters of the unit to be measured can be estimated with high accuracy even in presence of noise and obstacles in the fringe pattern.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: October 1, 2019
    Assignee: Beijing Institute of Technology
    Inventors: Mingfeng Lu, Jinmin Wu, Feng Zhang, Ran Tao
  • Patent number: 10398301
    Abstract: Cognitive function testing. At least some of example embodiments are methods including performing a cognitive function test on a patient without calibrating pupil position of the patient. The performing may include: causing a visual cue on a computer screen in front of the patient to move in a predetermined pattern; reading frames from an eye camera that captures images of an eye of the patient while the visual cue moves on the computer screen and the patient visually tracks the visual cue; determining pupil position within the frames; correcting offsets between the stimulus data and the pupil position data; translating the pupil position data from a coordinate space of the eye camera to a coordinate space of the stimulus data; and generating a test score being the cumulative distance between the stimulus data and pupil position data for each corresponding point in time.
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: September 3, 2019
    Assignee: EYEGUIDE, INC.
    Inventors: Nathan A. Jahnke, J. Brian Still, Gregory L. Gamel, Benedicto C. Baronia
  • Patent number: 10261069
    Abstract: Methods and apparatus for providing data processing and control for use in a medical communication system are provided.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: April 16, 2019
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Gary Alan Hayter, Kenneth J. Doniger
  • Patent number: 9833175
    Abstract: An apparatus for non-invasive blood glucose monitoring includes a light source for generating at least one ray of light, a beam splitter with a focusing function leads the light into an eyeball and focuses on the eyeball, a set of photo detectors for measuring optical angular information and absorption energy information of the light reflected from the eyeball and transmitted through the first beam splitter to the set of photo detectors, and a processing unit. The processing unit receives and processes the Optical angular information and the absorption energy information to obtain an Optical angular difference and an absorption energy difference between the light emitted from the light source and the light transmitted to the set of photo detectors, and analyzes the Optical angular difference and the absorption energy difference to obtain a glucose information, and since the glucose information has a corresponding relationship with a blood glucose information, the blood glucose information may be read.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: December 5, 2017
    Assignee: Taiwan Biophotonic Corporation
    Inventors: Yu-Tang Li, Chang-Sheng Chu, Chih-Hsun Fan, Shuang-Chao Chung, Ming-Chia Li, Jyh-Chern Chen, Kuo-Tung Tiao
  • Patent number: 9743864
    Abstract: A method for non-invasive blood glucose monitoring includes the following steps. At least one ray of light is emitted from at least one light source. The light emitted from the light source is leaded into an eyeball and focused on the eyeball through a first beam splitter. The reflected light reflected from the eyeball is transmitted through the first beam splitter to a set of photo detectors. Optical angular information and absorption energy information of the reflected light transmitted to the set of photo detectors are measured. Optical angular difference and absorption energy difference resulting from the light emitted from the light source and the reflected light transmitted to the set of photo detectors are obtained. Glucose information is obtained by analyzing the optical angular difference and the absorption energy difference, and since glucose information has a corresponding relationship with blood glucose information, blood glucose information may be read.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: August 29, 2017
    Assignee: Taiwan Biophotonic Corporation
    Inventors: Yu-Tang Li, Chang-Sheng Chu, Chih-Hsun Fan, Shuang-Chao Chung, Ming-Chia Li, Jyh-Chern Chen, Kuo-Tung Tiao
  • Patent number: 9737245
    Abstract: Disclosed is a flexible insert (100) for placement on the human eye, comprising a light source (110) in said insert such that light emitted from the light source is shielded from the human eye upon correct placement of the insert on the human eye, a light-responsive material (120) placed in the light path of the light source, said light-responsive material emitting light upon stimulation by the light from said light source, the intensity of said stimulated emission being sensitive to a chemical interaction of the light-sensitive material with an analyte of interest, a photodetector (130) for detecting the light emitted by the light-responsive material; and a transmitter (140) coupled to the photodetector for transmitting a photodetector reading. The insert may be used in conjunction with a reader for automated monitoring of an analyte of interest such as glucose in the tear fluid of its wearer.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: August 22, 2017
    Assignee: NXP B.V.
    Inventor: Willem Frederik Adrianus Besling
  • Patent number: 9710611
    Abstract: A method of managing insulin includes receiving blood glucose measurements on a computing device from a glucometer. The blood glucose measurements are separated by a time interval. The method includes determining, by the computing device, an insulin dose rate based on the blood glucose measurements and determining a blood glucose drop rate based on the blood glucose measurements and the time interval. The method also includes determining a blood glucose percentage drop based on the blood glucose measurements. The method includes decreasing the time interval between blood glucose measurements by the glucometer when the blood glucose drop rate is greater than a threshold drop rate, and decreasing the time interval between blood glucose measurements by the glucometer when the blood glucose percentage drop is greater than a threshold percentage drop.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: July 18, 2017
    Assignee: Aseko, Inc.
    Inventors: Robert C. Booth, Harry Hebblewhite
  • Patent number: 9681829
    Abstract: An eye-mountable device includes a transparent polymer and a structure embedded in the transparent polymer. The transparent polymer defines a posterior side and an anterior side of the eye-mountable device, and the transparent polymer has a concave surface and a convex surface. The structure includes a substrate, an antenna comprising a conductive loop, and a sensor that is configured to detect an analyte. The substrate includes a loop portion and a tab portion, where the loop portion has an outer circumference defined by an outer diameter and an inner circumference defined by an inner diameter, and where the tab portion extends from the inner circumference of the loop portion towards a center of the loop portion. The conductive loop is disposed on the loop portion of the substrate between the inner circumference and outer circumference, and the sensor is disposed on the tab portion of the substrate.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: June 20, 2017
    Assignee: Verily Life Sciences LLC
    Inventors: Brian Marc Pepin, James Etzkorn, Mandy Philippine, Stephen O'Driscoll
  • Patent number: 9603521
    Abstract: A measuring device for non-invasive determination of at least one physiological parameter includes at least one diagnostic sensor unit to generate measuring signals, and an evaluation unit for processing of measuring signals. The diagnostic sensor unit is integrated into or connectible to the keyboard of a computer or into a mobile device of entertainment or communication technology, with the diagnostic sensor unit including: an optical measuring unit including at least one radiation source for irradiation of the examined body tissue and at least one radiation sensor for detection of the radiation scattered and/or transmitted from the body tissue, and/or an ECG unit for capturing an ECG signal via two or more ECG electrodes, and/or a temperature or heat sensor, and/or a bio-electrical impedance measuring unit.
    Type: Grant
    Filed: November 23, 2007
    Date of Patent: March 28, 2017
    Assignee: Ingo Flore
    Inventors: Ok Kyung Cho, Yoon Ok Kim
  • Patent number: 9452260
    Abstract: Methods and systems for controlling analyte levels are described. An example method may include receiving a sensor measurement relating to an eye-mountable device. The method also may include determining an analyte concentration based on the one or more sensor measurements, and comparing the analyte concentration to a target analyte concentration. Based on the comparing, the method further may include providing instructions to a drug delivery device, where the instructions are configured to control a drug delivery rate by the drug delivery device.
    Type: Grant
    Filed: November 22, 2013
    Date of Patent: September 27, 2016
    Assignee: Verily Life Sciences LLC
    Inventor: Huanfen Yao
  • Patent number: 9445870
    Abstract: Methods and devices for delivering therapeutic or diagnostic energy (e.g., light, ultrasound, ionizing radiation (e.g., x-ray), vibration, heat energy, etc.) into the eye. An energy emitting device is positioned on the eye and used to deliver energy into the eye. The device may be constructed to allow the subject's eyelids to open and close while the device is positioned on the eye. The device is useable for various energy based or energy-mediated therapies, including crosslinking of corneal collagen, light therapy, photodynamic therapy, photo-activation of drugs, etc.
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: September 20, 2016
    Assignees: Montefiore Medical Center, Conversion Energy Enterprises Inc.
    Inventors: Roy S. Chuck, Barbara Ann Soltz, Robert Soltz
  • Patent number: 9421368
    Abstract: A system and method for relieving high blood sugar factor of diabetes includes an electric energy wave generator with a frequency effect level control mode. The frequency effect level control mode includes a control of a single frequency effect period and a control of a multi-frequency modulation effect period and controls and emits a single frequency electric energy wave to a diabetic patient's body in the single frequency effect period according to the frequency effect level control mode and controls and emits a multi-frequency electric energy wave in a multi-frequency modulation effect period, so as to reduce and eliminate a high blood sugar factor of the diabetic patient's body by the electric energy wave.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: August 23, 2016
    Assignee: TAIWAN RESONANTWAVE INC.
    Inventors: Wen-Chieh Chang, Sophia Kao
  • Patent number: 9047512
    Abstract: Apparatus, systems and methods for facilitating iris-scanning contact lenses and/or biometric identification employing iris scanning contact lenses are provided. In one implementation, the contact lens can include: a transparent substrate formed to cover at least a portion of an iris of an eye; and a circuit. The circuit can include: one or more light sensors disposed on or within the transparent substrate and that detects light filtered through the iris and incident on the one or more light sensors; readout circuitry, operably coupled to the one or more light sensors, that outputs information indicative of the light filtered through the iris and incident on the one or more light sensors; and a power component that supplies power to the readout circuitry. In various implementations, the contact lens can be employed in systems and/or methods associated with authentication and identification.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: June 2, 2015
    Assignee: Google Inc.
    Inventors: Brian Otis, Babak Parviz
  • Patent number: 9009958
    Abstract: A mountable device includes a bio-compatible structure embedded in a polymer that defines at least one mounting surface. The bio-compatible structure includes an electronic component having electrical contacts, sensor electrodes, and electrical interconnects between the sensor electrodes and the electrical contacts. The bio-compatible structure is fabricated such that it is fully encapsulated by a bio-compatible material, except for the sensor electrodes. In the fabrication, the electronic component is positioned on a first layer of bio-compatible material and a second layer of bio-compatible material is formed over the first layer of bio-compatible material and the electronic component. The electrical contacts are exposed by removing a portion of the second layer, a conductive pattern is formed to define the sensor electrodes and electrical interconnects, and a third layer of bio-compatible material is formed over the conductive pattern.
    Type: Grant
    Filed: September 23, 2013
    Date of Patent: April 21, 2015
    Assignee: Google Inc.
    Inventor: James Etzkorn
  • Patent number: 8979271
    Abstract: Apparatus, systems and methods employing contact lens sensors are provided. In some aspects, a contact lens includes a substrate and a circuit. The circuit can include: one or more sensors disposed on or within the substrate, that sense a feature associated with a wearer of the contact lens; and a compensation circuit disposed on or within the substrate, coupled to the sensor(s) and that outputs information to adjust an output of the sensor(s). The compensation circuit can include: a temperature component that senses the temperature of the sensor(s); and a communication component that outputs information indicative of the temperature of the sensor(s), and receives information associated with adjusting the output of the sensor(s). In other aspects, a contact lens includes a circuit that senses the body temperature, or ambient temperature outside of the body, of the contact lens wearer. Sensor fusion and/or calibration can be performed based on the information.
    Type: Grant
    Filed: September 25, 2012
    Date of Patent: March 17, 2015
    Assignee: Google Inc.
    Inventors: Nathan Pletcher, Zenghe Liu, Brian Otis
  • Patent number: 8974387
    Abstract: Various embodiments are described and illustrated to calculate an insulin bolus, recommend such bolus, and provide reminder messages for performing an additional glucose test.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: March 10, 2015
    Assignee: LifeScan Scotland Limited
    Inventors: Ian Shadforth, David Price, Gretchen Anderson, Lorraine Comstock, Mary McEvoy, Douglas Graham, Alexander Strachan, Alistair Longmuir, Robert Cavaye, Gillian Teft
  • Publication number: 20150005597
    Abstract: A body-mountable device can include a transparent material and a substrate at least partially embedded in the transparent material. The transparent material can have a mounting surface and a surface opposite the mounting surface. A light source can be disposed on the substrate and configured to emit light through the surface opposite the mounting surface. The light source can be controlled by circuitry disposed on the substrate. The circuitry can be configured to receive modulation instructions and modulate the light emitted by the light source based on the modulation instructions.
    Type: Application
    Filed: August 5, 2014
    Publication date: January 1, 2015
    Inventors: Robert Francis Wiser, Brian Otis, Andrew Nelson
  • Patent number: 8914089
    Abstract: Utilization of a contact device placed on the eye in order to detect physical and chemical parameters of the body as well as the non-invasive delivery of compounds according to these physical and chemical parameters, with signals being transmitted continuously as electromagnetic waves, radio waves, infrared and the like. One of the parameters to be detected includes non-invasive blood analysis utilizing chemical changes and chemical products that are found in the conjunctiva and in the tear film. A transensor mounted in the contact device laying on the cornea or the surface of the eye is capable of evaluating and measuring physical and chemical parameters in the eye including non-invasive blood analysis. The system utilizes eye lid motion and/or closure of the eye lid to activate a microminiature radio frequency sensitive transensor mounted in the contact device. The signal can be communicated by wires or radio telemetered to an externally placed receiver.
    Type: Grant
    Filed: June 13, 2008
    Date of Patent: December 16, 2014
    Assignee: Geelux Holdings, Ltd.
    Inventor: Marcio Marc Abreu
  • Publication number: 20140364709
    Abstract: A noninvasive method and apparatus for determining analyte concentration (e.g., glucose) in a subject that includes measuring light refraction from at least a portion one or more structures. One example of such structure is the subject's iris.
    Type: Application
    Filed: August 27, 2014
    Publication date: December 11, 2014
    Applicant: The University of Toledo
    Inventors: Brent D. Cameron, Anthony J. Webb
  • Patent number: 8881892
    Abstract: The present disclosure provides an apparatus including a first chamber containing an eye-mountable device. The apparatus may also include a second chamber containing an aqueous solution. The apparatus may also include a membrane positioned between the first chamber and the second chamber. The membrane may be configured to rupture based on application of a force to the apparatus. The ruptured membrane may allow the aqueous solution to engage with the eye-mountable device. The apparatus may also include a lid to seal one or more of the first chamber and the second chamber.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: November 11, 2014
    Assignee: Google Inc.
    Inventors: Jeffrey George Linhardt, Daniel Barrows
  • Patent number: 8870766
    Abstract: Systems and methods for non-invasively determining parameters related to blood glucose are disclosed. Embodiments are disclosed wherein a wearable sensor device comprises non-invasive sensors generating various sensed data which is then utilized to determine a glucose-related parameter.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: October 28, 2014
    Assignee: BodyMedia, Inc.
    Inventors: John M. Stivoric, Eric Teller, David Andre, Nisarg Vyas, Jonathan Farringdon, Donna Wolf, Christopher Pacione, Suresh Vishnubhatla, Scott Safier, Raymond Pelletier
  • Publication number: 20140249392
    Abstract: Non-invasive optical measurement of glucose and other dissolved substances in human or animal intraocular fluid. A method takes advantage of the fact that the wave dependence of optical activity is fundamentally different from corneal birefringence. The optical activity of substances dissolved in the intraocular fluid, such as glucose, lactate, ascorbic acid or amino acids, is scaled as a first approximation with the reciprocal value of the wavelength square. In contrast, corneal birefringence is scaled with the reciprocal value of the wavelength and therefore behaves considerably different from the optical activity. For the method according to the invention, a physical model is used, which describes the influence on the polarization of measurement radiation by the components of the eye, particularly by the intraocular fluid and the cornea.
    Type: Application
    Filed: April 2, 2014
    Publication date: September 4, 2014
    Inventor: Peter Westphal
  • Patent number: 8815178
    Abstract: The invention relates to a device and method for non-invasive detection of an analyte in a fluid sample. In one embodiment, the device comprises: a collection chamber containing an absorbent hydrogel material; a fluidic channel connected to the collection chamber; a sensing chamber connected to the fluidic channel, wherein the device is comprised of a compressible housing that allows transfer of fluid collected by the collection chamber to be transferred to be extracted and withdrawn to the sensing chamber upon compression of the device, wherein the sensing chamber contains a material that specifically detects the analyte and wherein the sensing chamber is operably linked to a processor containing a potentiostat that allows detection of the analyte using electrochemical sensing.
    Type: Grant
    Filed: March 25, 2010
    Date of Patent: August 26, 2014
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Daniel Bishop, Jeffrey La Belle
  • Patent number: 8812097
    Abstract: A non-invasive blood glucose concentration sensing system and method includes sensing neurophysiological brain activity of the user during visual pigment regeneration in an eye of the user, and correlating the sensed neurophysiological brain activity to the glucose concentration in the blood of the user.
    Type: Grant
    Filed: February 6, 2012
    Date of Patent: August 19, 2014
    Assignee: Honeywell International Inc.
    Inventors: Hans Roth, Santosh Mathan
  • Publication number: 20140192311
    Abstract: Apparatus, systems and methods of contact lenses with power sources are provided. In some aspects, a contact lens can include a substrate; and a circuit. The circuit can include: one or more sensors disposed on or within the substrate; circuitry disposed on at least a portion of the substrate; one or more photovoltaic cells disposed on at least a portion of the substrate; and a hybrid power component that supplies at least one of two or more different types of power to the circuitry, wherein at least one of the two or more different types of power is radio frequency/inductive power. In various aspects, other types of power can be solar and/or microelectromechanical system power. Additionally, in various aspects, photovoltaic cells can be arrayed in different configurations and/or over a significant portion of a viewing surface of the contact lens. In some aspects, the photovoltaic cells can be transparent.
    Type: Application
    Filed: July 26, 2012
    Publication date: July 10, 2014
    Applicant: GOOGLE INC.
    Inventors: Nathan Pletcher, Brian Otis
  • Patent number: 8774885
    Abstract: Utilization of a contact device placed on the eye in order to detect physical and chemical parameters of the body as well as the non-invasive delivery of compounds according to these physical and chemical parameters, with signals being transmitted continuously as electromagnetic waves, radio waves, infrared and the like. One of the parameters to be detected includes non-invasive blood analysis utilizing chemical changes and chemical products that are found in the conjunctiva and in the tear film. A transensor mounted in the contact device laying on the cornea or the surface of the eye is capable of evaluating and measuring physical and chemical parameters in the eye including non-invasive blood analysis. The system utilizes eye lid motion and/or closure of the eye lid to activate a microminiature radio frequency sensitive transensor mounted in the contact device. The signal can be communicated by wires or radio telemetered to an externally placed receiver.
    Type: Grant
    Filed: July 8, 2010
    Date of Patent: July 8, 2014
    Assignee: Geelux Holdings, Ltd.
    Inventor: Marcio Marc Abreu
  • Publication number: 20140180041
    Abstract: An apparatus for non-invasive glucose monitoring includes a first light source for emitting at least one ray of first light; a first beam splitter with a focusing function; a set of photo detectors for measuring optical rotatory distribution (ORD) information and absorption energy information of the first light reflected from the eyeball and transmitted through the first beam splitter to the set of photo detectors, and the first light emitted from the first light source being transmitted to the set of photo detectors by the first beam splitter and the eyeball to form an optical path; a processing unit receiving and processing the ORD information and the absorption energy information to obtain glucose information; and an eye positioning device including a second beam splitter disposed on the optical path between the first beam splitter and the eyeball and a camera for receiving image information transmitted from the second beam splitter.
    Type: Application
    Filed: December 27, 2013
    Publication date: June 26, 2014
    Applicant: Industrial Technology Research Institute
    Inventors: Yu-Tang Li, Chang-Sheng Chu, Chih-Hsun Fan, Shuang-Chao Chung, Ming-Chia Li, Jyh-Chern Chen, Kuo-Tung Tiao
  • Publication number: 20140171765
    Abstract: An apparatus for non-invasive glucose monitoring includes a light source for emitting at least one ray of light; a first beam splitter, a set of photo detectors for measuring optical rotatory distribution (ORD) information and absorption energy information; a reference component receiving the light from the first beam splitter, and the light reflected by the reference component being transmitted to the set of photo detectors by the first beam splitter, wherein the light emitted from the light source is transmitted to the set of photo detectors by the first beam splitter and the eyeball to form a first optical path, the light emitted from the light source is transmitted to the set of photo detectors by the first beam splitter and the reference component to form a second optical path; and a processing unit receiving and processing the ORD information and the absorption energy information to obtain a glucose information.
    Type: Application
    Filed: December 27, 2013
    Publication date: June 19, 2014
    Applicant: Industrial Technology Research Institute
    Inventors: Yu-Tang Li, Chang-Sheng Chu, Chih-Hsun Fan, Shuang-Chao Chung, Ming-Chia Li, Jyh-Chern Chen, Kuo-Tung Tiao
  • Patent number: 8755855
    Abstract: Non-invasive optical measurement of glucose and other dissolved substances in human or animal intraocular fluid. A method takes advantage of the fact that the wave dependence of optical activity is fundamentally different from corneal birefringence. The optical activity of substances dissolved in the intraocular fluid, such as glucose, lactate, ascorbic acid or amino acids, is scaled as a first approximation with the reciprocal value of the wavelength square. In contrast, corneal birefringence is scaled with the reciprocal value of the wavelength and therefore behaves considerably different from the optical activity. For the method according to the invention, a physical model is used, which describes the influence on the polarization of measurement radiation by the components of the eye, particularly by the intraocular fluid and the cornea.
    Type: Grant
    Filed: March 2, 2009
    Date of Patent: June 17, 2014
    Assignee: Carl Zeiss AG
    Inventor: Peter Westphal
  • Publication number: 20140163329
    Abstract: Methods and systems for determining a physiological parameter of a subject through interrogation of an eye of the subject with an optical signal are described. Interrogation is performed unobtrusively. The system includes a gaze attractor for attracting the gaze of the subject to cause an eye of the subject to move into alignment with regard to an interrogation signal source and/or response signal sensor to facilitate detection of a signal from the eye of the subject.
    Type: Application
    Filed: December 11, 2012
    Publication date: June 12, 2014
    Applicant: Elwha LLC
    Inventors: Allen L. Brown, JR., Douglas C. Burger, Eric Horvitz, Roderick A. Hyde, Edward K.Y. Jung, Eric C. Leuthardt, Jordin T. Kare, Chris Demetrios Karkanias, John L. Manferdelli, Craig J. Mundie, Nathan P. Myhrvold, Barney Pell, Clarence T. Tegreene, Willard H. Wattenburg, Charles Whitmer, Lowell L. Wood, JR., Richard N. Zare
  • Patent number: 8718734
    Abstract: A noninvasive polarimetric apparatus used to measure levels of a substance in a sample in the presence of dynamically changing sample birefringence is provided. A polarization system generates multiple states of polarized light which interact with the sample. An analyzer system receives a signal from the sample and generates a secondary signal. This signal is detected and then processed to measure levels of a substance in a sample that may be have time varying birefringent components.
    Type: Grant
    Filed: November 7, 2008
    Date of Patent: May 6, 2014
    Assignee: The University of Toledo
    Inventor: Brent D. Cameron
  • Publication number: 20140107438
    Abstract: The inventive concept relates to a measuring device. The measuring device irradiates a first beam including a polarization component and a second beam which is a wavelength swept laser having a coherence length previously set and can measure a glucose concentration of an aqueous humor by measuring an optical path length and the rotation amount of a polarization plane respectively from a first output beam and a second output beam being output from an eye.
    Type: Application
    Filed: October 16, 2013
    Publication date: April 17, 2014
    Applicant: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventor: Hyun Woo SONG
  • Patent number: 8690820
    Abstract: A method and device for monitoring or treating patient glucose levels. The device includes a glucose sensor for measuring a glucose level of a patient, a physiological status monitoring system for measuring at least one physical or metabolic variable of the patient, and an automatic controller in communication with the glucose sensor and the physiological status monitoring system. The controller includes a prediction module for automatically predicting a future glucose level using data measured by the glucose sensor and the physiological sensor.
    Type: Grant
    Filed: October 5, 2010
    Date of Patent: April 8, 2014
    Assignee: Illinois Institute of Technology
    Inventors: Ali Cinar, Meriyan Oruklu
  • Patent number: 8679016
    Abstract: A closed loop system or semi-closed loop system for infusing insulin using sensor values applies a redundant sensor system as a fail-safe method against sensor failure. The redundant glucose sensors are used corroborate each other and a failing sensor is detected if the sensors no longer corroborate each other. The use of redundant sensors has the additional benefit of producing better sensor signals compared to the use of a single sensor.
    Type: Grant
    Filed: April 13, 2011
    Date of Patent: March 25, 2014
    Assignee: Medtronic MiniMed, Inc.
    Inventors: John J. Mastrototaro, Richard K. Yoon, Desmond Barry Keenan
  • Patent number: 8641617
    Abstract: A system for in-place visualization of sensed data is provided. The system includes a formable sheet comprising a display and sensors embedded within the sheet underneath the display. The display will display information relating to sensed data on a portion of the display corresponding to locations of the sensors located underneath the display. As a result, the display displays the information above or directly above the sensors that output data.
    Type: Grant
    Filed: August 28, 2009
    Date of Patent: February 4, 2014
    Assignee: Indian Institute of Science
    Inventor: Vijay Natarajan
  • Patent number: 8639306
    Abstract: An eye-property monitoring system and method for performing the steps of (1) illuminating the eye from at least one light source whose wavelength interacts with internal eye properties in an optically active manner, (2) controlling, to make known and stable, the operating-power/light-output level of the source, (3) by such illuminating, producing light-source eye reflections including (a) multiple internal reflections within the outer structure of the eye, and (b) linked with those internal reflections at least one resulting outbound reflection, (4) monitoring the outbound-reflection to detect therein the reflection level associated with the at least one source, and (5) associating such detected reflection level as an indication of certain eye properties, such as aqueous glucose concentration.
    Type: Grant
    Filed: February 4, 2012
    Date of Patent: January 28, 2014
    Assignee: Brien Holden Vision Diagnostics, Inc.
    Inventor: Tom N. Cornsweet
  • Patent number: 8608310
    Abstract: A contact lens having an integrated glucose sensor is provided. The contact lens includes an electrochemical sensor configured to measure the level of glucose in the tear fluid of the eye of the user wearing the contact lens. The electrochemical sensor is powered by radiation off-lens, through an RF antenna or a photovoltaic device mounted on the periphery of the contact lens. The power provided to the contact lens also enables transmission of data from the electrochemical sensor, for example by backscatter communications or optically by an LED mounted to the lens.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: December 17, 2013
    Assignee: University of Washington through its Center for Commercialization
    Inventors: Brian Otis, Yu-Te Liao, Babak Amirparviz, Huanfen Yao
  • Patent number: 8597570
    Abstract: Provided are a measurement device by which the blood-sugar level or the like associated with the living activity of a diabetic patient can be measured easily and precisely and the measured valued associated with the living activity can be clinically applied easily, and an insulin infusion device, a measurement method, a method for controlling an insulin fusion device, and a program. A blood-sugar level measurement device (100) is provided with a blood-sugar level sensor (200) and an acceleration sensor (112) for measuring movement information associated with human body activity, wherein a CPU (110 controls, on the basis of the measured movement information, whether or not the measurement operation of a blood-sugar measurement circuit (113) can be executed.
    Type: Grant
    Filed: October 27, 2009
    Date of Patent: December 3, 2013
    Assignee: Panasonic Corporation
    Inventors: Noriyoshi Terashima, Masataka Nadaoka
  • Patent number: 8554296
    Abstract: An in vivo determination of the presence or concentration of an endogenous or exogenous substance by photoacoustically assaying the substance in the eye and correlating the presence or concentration of the substance in the eye to the presence or concentration of the substance in the blood, without removing a tissue or fluid sample from the body for assay. The eye, unlike other body sites such as the skin, has a relatively constant pressure and temperature, providing an additional utility for the inventive method.
    Type: Grant
    Filed: February 20, 2012
    Date of Patent: October 8, 2013
    Inventor: Gholam A. Peyman
  • Patent number: 8552892
    Abstract: A signal sample trigger apparatus (206) comprises an input (302, 304), a processing resource (300, 500) coupled to the input (302, 304), and an output (306) coupled to the processing resource (300, 500). The processing resource (300, 500) is arranged to generate, when in use, a trigger signal (400, 600) in response to location increment information. The location increment information (402, 404, 602, 604) is received via the input (302, 304), and the trigger signal (400, 600) is provided via the output for triggering execution of a sample of an analogue signal.
    Type: Grant
    Filed: January 25, 2010
    Date of Patent: October 8, 2013
    Assignee: Lein Applied Diagnostics Limited
    Inventor: Robin Taylor
  • Patent number: 8452363
    Abstract: The invention proposes a manual measuring appliance (112) and an analytical measuring system (110) which can be used to measure at least one analyte in an eye fluid of an eye (114). The handheld measuring appliance (112) comprises a measuring system (120) and a positioning system (122). The measuring system (120) can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor (116) in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system (122) is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye (114) and the handheld measuring appliance (112) and also furthermore at least one further positioning co-ordinate.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: May 28, 2013
    Assignee: Eyesense AG
    Inventors: Achim Müller, Peter Herbrechtsmeier, Klaus Haberstroh, Roman Gruler
  • Patent number: 8385998
    Abstract: The present invention provides contact lens with integrated biosensor for the continuous, non-invasive monitoring of physiological glucose by employing biocompatible nanostructure-laden lens materials. These contact lenses can be worn by diabetics who can colorimetrically see changes in their contact lens color or other fluorescence-based properties, giving an indication of tear and blood glucose levels. This invention for the glucose biosensor based on the new disposal contact lens provides a safe, convenient and non-expensive glucose sensing device. The sensing device disclosed herein provides an efficient and noninvasive solution for monitoring blood glucose.
    Type: Grant
    Filed: October 26, 2009
    Date of Patent: February 26, 2013
    Inventors: Jin Zhang, William Gerald Hodge
  • Patent number: 8364219
    Abstract: An apparatus and method for measuring a concentration of a substance in an eye using a retro-reflected measurement light beam having a first wavelength at which the substance has a non-zero first absorption coefficient and a retro-reflected reference light beam having a second wavelength at which the substance has a second absorption coefficient which is substantially equal to zero. The apparatus further includes a detector positionable to receive the retro-reflected measurement light beam and the retro-reflected reference light beam. The detector is responsive to light having the first wavelength by generating a measurement signal and responsive to light having the second wavelength by generating a reference signal. The apparatus further includes an electrical circuit coupled to the detector. The electrical circuit is responsive to the measurement signal and the reference signal to measure the concentration of the substance in the eye.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: January 29, 2013
    Assignee: Gluco Vista, Inc.
    Inventor: Jonathan Gerlitz
  • Patent number: 8323195
    Abstract: A blood glucose measurement system in which a blood glucose level measured with an invasive blood glucose measurement apparatus 101 is used to calibrate a blood glucose level measured with a non-invasive blood glucose measurement apparatus 102, comprising a controller that outputs an invasive actuation signal that starts the detection of a characteristic quantity in the body with the invasive blood glucose measurement apparatus, and a blood sampling component for collecting blood from the body on the basis of the invasive actuation signal, wherein measurement with the invasive blood glucose measurement apparatus is begun when the amount of change in the estimated blood glucose level has reached or exceeded a non-invasive blood glucose threshold.
    Type: Grant
    Filed: December 31, 2008
    Date of Patent: December 4, 2012
    Assignee: Panasonic Corporation
    Inventors: Yasushi Ueda, Mamiko Akizuki, Hiroyoshi Inoshita
  • Publication number: 20120277556
    Abstract: An apparatus for non-invasive blood glucose monitoring includes a light source for generating at least one ray of light, a beam splitter with a focusing function leads the light into an eyeball and focuses on the eyeball, a set of photo detectors for measuring optical rotatory distribution (ORD) information and absorption energy information of the reflected light reflected from the eyeball and transmitted through the first beam splitter to the set of photo detectors, and a processing unit. The processing unit receives and processes the ORD information and the absorption energy information to obtain an ORD difference and an absorption energy difference resulting from the light emitted from the light source and the reflected light transmitted to the set of photo detectors, and analyzes the ORD difference and the absorption energy difference to obtain a glucose information to read the blood glucose information.
    Type: Application
    Filed: April 27, 2012
    Publication date: November 1, 2012
    Applicant: Industrial Technology Research Institute
    Inventors: Yu-Tang Li, Chang-Sheng Chu, Chih-Hsun Fan, Shuang-Chao Chung, Ming-Chia Li, Jyh-Chern Chen, Kuo-Tung Tiao
  • Publication number: 20120277557
    Abstract: A method for non-invasive blood glucose monitoring includes the following steps. At least one ray of light is emitted from at least one light source. The light emitted from the light source is leaded into an eyeball and focused on the eyeball through a first beam splitter. The reflected light reflected from the eyeball is transmitted through the first beam splitter to a set of photo detectors. Optical rotatory distribution (ORD) information and absorption energy information of the reflected light transmitted to the set of photo detectors are measured. ORD difference and absorption energy difference resulting from the light emitted from the light source and the reflected light transmitted to the set of photo detectors are obtained. Glucose information is obtained by analyzing the ORD difference and the absorption energy difference, and since glucose information has a corresponding relationship with blood glucose information, blood glucose information may be read.
    Type: Application
    Filed: April 27, 2012
    Publication date: November 1, 2012
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Yu-Tang Li, Chang-Sheng Chu, Chih-Hsun Fan, Shuang-Chao Chung, Ming-Chia Li, Jyh-Chern Chen, Kuo-Tung Tiao
  • Publication number: 20120268714
    Abstract: A noninvasive method and apparatus for determining analyte concentration (e.g., glucose) in a subject that includes measuring light refraction from at least a portion one or more structures. One example of such structure is the subject's iris.
    Type: Application
    Filed: October 7, 2010
    Publication date: October 25, 2012
    Applicant: UNIVERSITY OF TOLEDO
    Inventors: Brent D. Cameron, Anthony Webb
  • Publication number: 20120259188
    Abstract: Disclosed is a flexible insert (100) for placement on the human eye, comprising a light source (110) in said insert such that light emitted from the light source is shielded from the human eye upon correct placement of the insert on the human eye, a light-responsive material (120) placed in the light path of the light source, said light-responsive material emitting light upon stimulation by the light from said light source, the intensity of said stimulated emission being sensitive to a chemical interaction of the light-sensitive material with an analyte of interest, a photodetector (130) for detecting the light emitted by the light-responsive material; and a transmitter (140) coupled to the photodetector for transmitting a photodetector reading. The insert may be used in conjunction with a reader for automated monitoring of an analyte of interest such as glucose in the tear fluid of its wearer.
    Type: Application
    Filed: March 30, 2012
    Publication date: October 11, 2012
    Applicant: NXP B.V.
    Inventor: Willem Frederik Adrianus Besling
  • Publication number: 20120215079
    Abstract: An eye-property monitoring system and method for performing the steps of (1) illuminating the eye from at least one light source whose wavelength interacts with internal eye properties in an optically active manner, (2) controlling, to make known and stable, the operating-power/light-output level of the source, (3) by such illuminating, producing light-source eye reflections including (a) multiple internal reflections within the outer structure of the eye, and (b) linked with those internal reflections at least one resulting outbound reflection, (4) monitoring the outbound-reflection to detect therein the reflection level associated with the at least one source, and (5) associating such detected reflection level as an indication of certain eye properties, such as aqueous glucose concentration.
    Type: Application
    Filed: February 4, 2012
    Publication date: August 23, 2012
    Applicant: Quantum Catch, LLC
    Inventor: Tom N. Cornsweet