Determining Constituents In Eye Patents (Class 600/318)
  • Patent number: 10349831
    Abstract: An optical measuring instrument 1 is equipped with an optical system 20 to be used for measuring a characteristic of the aqueous humor in the anterior chamber 13 of an eyeball 10 of a measurement subject person and a holding unit 50 which holds the optical system 20 etc. The optical system 20 is equipped with a light emitting system 20A and a photodetecting system 20B. An optical path 28 is set so that light emitted from the light emitting system 20A passes through (traverses) the anterior chamber 13 and is detected by the photodetecting system 20B in a state that the eyeball 10 is turned outward.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: July 16, 2019
    Assignee: FUJI XEROX CO., LTD.
    Inventors: Kazuyuki Matsushita, Kazutaka Takeda, Kohei Yukawa, Hideaki Ozawa, Taku Kinoshita, Hideo Nakayama
  • Patent number: 9961307
    Abstract: An eyeglass recorder includes multiple scene cameras for respectively recording frontal scenes along the viewer's horizontal line-of-sight and depending scenes at approximately a 45° angle downwardly from the viewer's horizontal line-of-sight. The viewer's eye movement is concurrently monitored to differentiate between the viewing of the recorded frontal and depending scenes and to detect saccadic eye motion for assessment of the viewer's level of interest in the viewed scenes.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: May 1, 2018
    Inventor: Lee S. Weinblatt
  • Patent number: 9924895
    Abstract: A specialized spectrometer comprises a light source to generate a monochromatic light beam to generate resonance Raman peaks or resonance near infrared absorption peaks from a region of the subject and a reference light source to illuminate the region with a reference light beam. The light energy from the resonance Raman peaks can be measured with a detector coupled to an optical wavelength separator. A portion of the reference beam scattered from the region can be measured with a reference detector. An amount of the constituent can be determined with a processor in response to the resonance Raman peaks measured with the detector and the portion of the reference beam measured with the reference detector. The illumination of the region with reference beam with the monochromatic beam allows accurate determination of the amount of the constituent, and the amount may comprise a concentration, such as an amount per unit volume.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: March 27, 2018
    Assignee: LivSpek Medical Technologies Inc.
    Inventors: Andrew H. Rawicz, Sara Moghaddamjoo, Bruno Jaggi
  • Patent number: 9915829
    Abstract: The present invention discloses methods and apparatus for methods and apparatus for manufacturing an Ophthalmic Lens with passive event coloration mechanisms, which may not require a power source. In some embodiments, the passive event coloration mechanisms may be combined with Rigid Inserts or Media Inserts, wherein the inserts may provide additional functionalities.
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: March 13, 2018
    Assignee: Johnson & Johnson Vision Care, Inc.
    Inventors: Randall B. Pugh, Karson S. Putt, Camille Higham, Sharika Snook
  • Patent number: 9671347
    Abstract: Present disclosure relates to a method of diagnosing malaria infection in a patient by Surface Enhanced Raman Spectroscopy (SERS). The method includes obtaining a sample from said patient, mixing the sample with a suspension of magnetic nanoparticles, wherein said magnetic nanoparticles adsorb hemozoin present in the sample onto their surface, obtaining the SERS spectra of the sample, and correlating the obtained SERS spectra to the presence or amount of hemozoin in the sample, wherein the presence of hemozoin is indicative of malaria infection.
    Type: Grant
    Filed: April 9, 2012
    Date of Patent: June 6, 2017
    Assignee: Nanyang Technological University
    Inventors: Quan Liu, Clement Yuen
  • Patent number: 9658440
    Abstract: An optical probe for measuring light signals includes a first optical fiber guiding incoming light, a lens focusing incoming light towards a sample and collecting altered light from the sample, a second optical fiber guiding altered light, a light logging device measuring intensity fluctuations in the incoming light, wherein the light logging device is positioned after the first optical fiber, whereby the light logging device receives a part of the incoming light from the first fiber. The optical probe is normally applied for measuring light signals in vivo, and finds its primary applications within the field of optical spectroscopic measurements, where the light signals measured by the probe are applied in combination with an apparatus wherein light signals are analyzed against its spectral components for instance in Raman, fluorescence, phosphorescence absorption, diffusion and transmission studies.
    Type: Grant
    Filed: March 12, 2009
    Date of Patent: May 23, 2017
    Assignee: RSP SYSTEMS A/S
    Inventor: Morten Henneberg
  • Patent number: 9610032
    Abstract: A body-mountable device can include a transparent material and a substrate at least partially embedded in the transparent material. The transparent material can have a mounting surface and a surface opposite the mounting surface. A light source can be disposed on the substrate and configured to emit light through the surface opposite the mounting surface. The light source can be controlled by circuitry disposed on the substrate. The circuitry can be configured to receive modulation instructions and modulate the light emitted by the light source based on the modulation instructions.
    Type: Grant
    Filed: August 5, 2014
    Date of Patent: April 4, 2017
    Assignee: Verily Life Sciences LLC
    Inventors: Robert Francis Wiser, Brian Otis, Andrew Nelson
  • Patent number: 9492630
    Abstract: There are disclosed a wearable computing device and a method for a user interface. The wearable computing device includes a drowsiness detection unit configured to detect a user's drowsiness; a controller configured to determine whether a current situation corresponds to a first mode not allowing the user's drowsiness or a second mode allowing the user's drowsiness when the user's drowsiness is detected; and a feedback output unit configured to provide the user with at least one feedback comprising a message of the first mode or the second mode according to the mode determined by the controller, wherein the message of the first mode is to fight off the drowsiness and wherein the message of the second mode is to help the user's sleep.
    Type: Grant
    Filed: January 29, 2014
    Date of Patent: November 15, 2016
    Assignee: LG Electronics Inc.
    Inventors: Eunhyung Cho, Sinae Chun, Jongho Kim, Jihwan Kim
  • Patent number: 9423635
    Abstract: Described herein is an integrated Faraday modulator and Faraday compensator (IFMC) system. Further described are methods of making an IFMC system, methods of customizing an IFMC system for a specific application, and methods of optimizing an IFMC system for a specific application. Further described is a robust 3D Finite Element Model (FEM) for designing and optimizing an IFMC system. Further described are optical instruments comprising an integrated Faraday modulator and Faraday compensator requiring only one optical crystal.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: August 23, 2016
    Assignee: The University of Toledo
    Inventors: Brent D. Cameron, Brandon W. Clarke
  • Patent number: 9125609
    Abstract: A portable terminal device capable of measuring and evaluating mental fatigue, its measuring method, and a server computer is provided. The portable terminal device includes an operation unit; an imaging unit; a display screen or light emitting element; and a recording unit. Environmental data, which represents ambient environmental light, is calculated by capturing at least a reference image, first frequency data measured when the user is healthy is associated with first environmental data at the time of the measurement, and the associated data is stored in the recording unit; and a proportion of decrease of second frequency data measured when the user is not healthy from the first frequency data associated with the first environmental data having the same order of magnitude as that of second environmental data at the time of the measurement is calculated to evaluate the degree of fatigue of the user.
    Type: Grant
    Filed: August 27, 2009
    Date of Patent: September 8, 2015
    Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Nobuyoshi Harada, Sunao Iwaki
  • Patent number: 9055902
    Abstract: An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent that selectively reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. The working electrode can have at least one dimension less than 25 micrometers. The reference electrode can have an area at least five times greater than an area of the working electrode. A portion of the polymeric material can surround the working electrode and the reference electrode such that an electrical current conveyed between the working electrode and the reference electrode is passed through the at least partially surrounding portion of the transparent polymeric material.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: June 16, 2015
    Assignee: Google Inc.
    Inventor: Zenghe Liu
  • Patent number: 9014639
    Abstract: The present invention provides methods of notifying a user of a smartphone event through use of an energizable ophthalmic lens. In some embodiments, the smartphone may be paired with a specified ophthalmic lens, wherein the pairing may limit wireless communication to communication between the two specified devices. The smartphone may transmit smartphone event data, which may activate an indicator in the ophthalmic lens. In some embodiments, the user may respond to the notification of the smartphone event. The response may trigger an internal action within the ophthalmic lens, or the response may be transmitted to the smartphone, triggering an action in the smartphone. The present invention further describes a method of using an ophthalmic lens with a smartphone event indicator, including methods of pairing an ophthalmic lens with the specified smartphone.
    Type: Grant
    Filed: July 11, 2013
    Date of Patent: April 21, 2015
    Assignee: Johnson & Johnson Vision Care, Inc.
    Inventors: Randall Braxton Pugh, Camille A. Higham
  • Publication number: 20150085249
    Abstract: Utilization of a contact device placed on the eye in order to detect physical and chemical parameters of the body as well as the non-invasive delivery of compounds according to these physical and chemical parameters, with signals being transmitted continuously as electromagnetic waves, radio waves, infrared and the like. One of the parameters to be detected includes non-invasive blood analysis utilizing chemical changes and chemical products that are found in the conjunctiva and in the tear film. A transensor mounted in the contact device laying on the cornea or the surface of the eye is capable of evaluating and measuring physical and chemical parameters in the eye including non-invasive blood analysis. The system utilizes eye lid motion and/or closure of the eye lid to activate a microminiature radio frequency sensitive transensor mounted in the contact device. The signal can be communicated by wires or radio telemetered to an externally placed receiver.
    Type: Application
    Filed: November 24, 2014
    Publication date: March 26, 2015
    Applicant: GEELUX HOLDING, LTD.
    Inventor: Marcio Marc ABREU
  • Patent number: 8971978
    Abstract: Apparatus, systems and methods employing a contact lens having a pulse oximetry sensor to detect information indicative of a blood oxygen content and/or pulse rate of a wearer of the contact lens, are provided. In some aspects, a contact lens includes a substrate that forms at least part of a body of the contact lens and a pulse oximetry sensor located on or within the substrate that detects information associated with at least one of blood oxygen content or a pulse rate of a wearer of the contact lens. The pulse oximetry sensor comprises one or more light emitting diodes that illuminate a blood vessel of at least one of a region of an eye or an eyelid and a detector that receives light reflected from the blood vessel and generates the information.
    Type: Grant
    Filed: August 21, 2012
    Date of Patent: March 3, 2015
    Assignee: Google Inc.
    Inventors: Harvey Ho, Babak Amirparviz
  • Publication number: 20150038809
    Abstract: An eye-mountable device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode and a reference electrode that reacts with an analyte to generate a sensor measurement related to a concentration of the analyte in a fluid to which the eye-mountable device is exposed. An example assembly process includes: forming a sacrificial layer on a working substrate; forming a first layer of a bio-compatible material on the sacrificial layer; providing an electronics module on the first layer of the bio-compatible material, forming a second layer of the bio-compatible material to cover the electronics module; and annealing the first and second layers of the bio-compatible material together to form an encapsulated structure having the electronics module fully encapsulated by the bio-compatible material.
    Type: Application
    Filed: October 20, 2014
    Publication date: February 5, 2015
    Inventors: James Etzkorn, Babak Amirparviz
  • Patent number: 8914089
    Abstract: Utilization of a contact device placed on the eye in order to detect physical and chemical parameters of the body as well as the non-invasive delivery of compounds according to these physical and chemical parameters, with signals being transmitted continuously as electromagnetic waves, radio waves, infrared and the like. One of the parameters to be detected includes non-invasive blood analysis utilizing chemical changes and chemical products that are found in the conjunctiva and in the tear film. A transensor mounted in the contact device laying on the cornea or the surface of the eye is capable of evaluating and measuring physical and chemical parameters in the eye including non-invasive blood analysis. The system utilizes eye lid motion and/or closure of the eye lid to activate a microminiature radio frequency sensitive transensor mounted in the contact device. The signal can be communicated by wires or radio telemetered to an externally placed receiver.
    Type: Grant
    Filed: June 13, 2008
    Date of Patent: December 16, 2014
    Assignee: Geelux Holdings, Ltd.
    Inventor: Marcio Marc Abreu
  • Patent number: 8909311
    Abstract: Apparatus, systems and methods employing a contact lens having a pulse oximetry sensor to detect information indicative of a blood oxygen content and/or pulse rate of a wearer of the contact lens, are provided. In some aspects, a contact lens includes a substrate that forms at least part of a body of the contact lens and a pulse oximetry sensor located on or within the substrate that detects information associated with at least one of blood oxygen content or a pulse rate of a wearer of the contact lens. The pulse oximetry sensor comprises one or more light emitting diodes that illuminate a blood vessel of at least one of a region of an eye or an eyelid and a detector that receives light reflected from the blood vessel and generates the information.
    Type: Grant
    Filed: September 17, 2013
    Date of Patent: December 9, 2014
    Assignee: Google Inc.
    Inventors: Harvey Ho, Babak A. Parviz
  • Patent number: 8905930
    Abstract: Methods, systems, and software for controlling infusion pressure, such as during a medical procedure, using systemic blood pressure are described. Systemic blood pressure, such as brachial arm blood pressure or radial artery blood pressure, may be used to estimate central retinal artery blood pressure to estimate critical closing pressure. Further, the disclosure relates to controlling infusion pressure to prevent an increase in intraocular pressure above the estimated critical closing pressure when such is not desired, and, when such is desired, using systemic blood pressure and infusion pressure to control an intentional increase in intraocular pressure above the estimated critical closing pressure to stop intraocular bleeding.
    Type: Grant
    Filed: May 20, 2011
    Date of Patent: December 9, 2014
    Assignee: Alcon Research, Ltd.
    Inventor: Steven T. Charles
  • Publication number: 20140249392
    Abstract: Non-invasive optical measurement of glucose and other dissolved substances in human or animal intraocular fluid. A method takes advantage of the fact that the wave dependence of optical activity is fundamentally different from corneal birefringence. The optical activity of substances dissolved in the intraocular fluid, such as glucose, lactate, ascorbic acid or amino acids, is scaled as a first approximation with the reciprocal value of the wavelength square. In contrast, corneal birefringence is scaled with the reciprocal value of the wavelength and therefore behaves considerably different from the optical activity. For the method according to the invention, a physical model is used, which describes the influence on the polarization of measurement radiation by the components of the eye, particularly by the intraocular fluid and the cornea.
    Type: Application
    Filed: April 2, 2014
    Publication date: September 4, 2014
    Inventor: Peter Westphal
  • Patent number: 8817261
    Abstract: Laser pulses are applied to surface plasmon resonant articles such as gold nanoparticles within a microscopy sample to generate a four-wave mixing signal that is detected as the output of the microscopy process.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: August 26, 2014
    Assignee: University College Cardiff Consultants Ltd.
    Inventors: Paola Borri, Wolfgang Langbein, Francesco Masia
  • Patent number: 8815178
    Abstract: The invention relates to a device and method for non-invasive detection of an analyte in a fluid sample. In one embodiment, the device comprises: a collection chamber containing an absorbent hydrogel material; a fluidic channel connected to the collection chamber; a sensing chamber connected to the fluidic channel, wherein the device is comprised of a compressible housing that allows transfer of fluid collected by the collection chamber to be transferred to be extracted and withdrawn to the sensing chamber upon compression of the device, wherein the sensing chamber contains a material that specifically detects the analyte and wherein the sensing chamber is operably linked to a processor containing a potentiostat that allows detection of the analyte using electrochemical sensing.
    Type: Grant
    Filed: March 25, 2010
    Date of Patent: August 26, 2014
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Daniel Bishop, Jeffrey La Belle
  • Patent number: 8798699
    Abstract: Methods, apparatus, and systems for detecting hemozoin and diagnosing malaria infection are disclosed.
    Type: Grant
    Filed: July 16, 2012
    Date of Patent: August 5, 2014
    Inventors: Roderick A. Hyde, Nathan P. Myhrvold, Clarence T. Tegreene, Lowell L. Wood, Jr.
  • Publication number: 20140194708
    Abstract: Apparatus, systems and methods employing a contact lens having a pulse oximetry sensor to detect information indicative of a blood oxygen content and/or pulse rate of a wearer of the contact lens, are provided. In some aspects, a contact lens includes a substrate that forms at least part of a body of the contact lens and a pulse oximetry sensor located on or within the substrate that detects information associated with at least one of blood oxygen content or a pulse rate of a wearer of the contact lens. The pulse oximetry sensor comprises one or more light emitting diodes that illuminate a blood vessel of at least one of a region of an eye or an eyelid and a detector that receives light reflected from the blood vessel and generates the information.
    Type: Application
    Filed: August 21, 2012
    Publication date: July 10, 2014
    Applicant: GOOGLE INC.
    Inventors: Harvey Ho, Babak Amirparviz
  • Publication number: 20140192311
    Abstract: Apparatus, systems and methods of contact lenses with power sources are provided. In some aspects, a contact lens can include a substrate; and a circuit. The circuit can include: one or more sensors disposed on or within the substrate; circuitry disposed on at least a portion of the substrate; one or more photovoltaic cells disposed on at least a portion of the substrate; and a hybrid power component that supplies at least one of two or more different types of power to the circuitry, wherein at least one of the two or more different types of power is radio frequency/inductive power. In various aspects, other types of power can be solar and/or microelectromechanical system power. Additionally, in various aspects, photovoltaic cells can be arrayed in different configurations and/or over a significant portion of a viewing surface of the contact lens. In some aspects, the photovoltaic cells can be transparent.
    Type: Application
    Filed: July 26, 2012
    Publication date: July 10, 2014
    Applicant: GOOGLE INC.
    Inventors: Nathan Pletcher, Brian Otis
  • Patent number: 8774885
    Abstract: Utilization of a contact device placed on the eye in order to detect physical and chemical parameters of the body as well as the non-invasive delivery of compounds according to these physical and chemical parameters, with signals being transmitted continuously as electromagnetic waves, radio waves, infrared and the like. One of the parameters to be detected includes non-invasive blood analysis utilizing chemical changes and chemical products that are found in the conjunctiva and in the tear film. A transensor mounted in the contact device laying on the cornea or the surface of the eye is capable of evaluating and measuring physical and chemical parameters in the eye including non-invasive blood analysis. The system utilizes eye lid motion and/or closure of the eye lid to activate a microminiature radio frequency sensitive transensor mounted in the contact device. The signal can be communicated by wires or radio telemetered to an externally placed receiver.
    Type: Grant
    Filed: July 8, 2010
    Date of Patent: July 8, 2014
    Assignee: Geelux Holdings, Ltd.
    Inventor: Marcio Marc Abreu
  • Patent number: 8755855
    Abstract: Non-invasive optical measurement of glucose and other dissolved substances in human or animal intraocular fluid. A method takes advantage of the fact that the wave dependence of optical activity is fundamentally different from corneal birefringence. The optical activity of substances dissolved in the intraocular fluid, such as glucose, lactate, ascorbic acid or amino acids, is scaled as a first approximation with the reciprocal value of the wavelength square. In contrast, corneal birefringence is scaled with the reciprocal value of the wavelength and therefore behaves considerably different from the optical activity. For the method according to the invention, a physical model is used, which describes the influence on the polarization of measurement radiation by the components of the eye, particularly by the intraocular fluid and the cornea.
    Type: Grant
    Filed: March 2, 2009
    Date of Patent: June 17, 2014
    Assignee: Carl Zeiss AG
    Inventor: Peter Westphal
  • Publication number: 20140163329
    Abstract: Methods and systems for determining a physiological parameter of a subject through interrogation of an eye of the subject with an optical signal are described. Interrogation is performed unobtrusively. The system includes a gaze attractor for attracting the gaze of the subject to cause an eye of the subject to move into alignment with regard to an interrogation signal source and/or response signal sensor to facilitate detection of a signal from the eye of the subject.
    Type: Application
    Filed: December 11, 2012
    Publication date: June 12, 2014
    Applicant: Elwha LLC
    Inventors: Allen L. Brown, JR., Douglas C. Burger, Eric Horvitz, Roderick A. Hyde, Edward K.Y. Jung, Eric C. Leuthardt, Jordin T. Kare, Chris Demetrios Karkanias, John L. Manferdelli, Craig J. Mundie, Nathan P. Myhrvold, Barney Pell, Clarence T. Tegreene, Willard H. Wattenburg, Charles Whitmer, Lowell L. Wood, JR., Richard N. Zare
  • Patent number: 8740384
    Abstract: A method and apparatus for measuring a molecular composition of protein molecules. A fluid containing at least two varieties of protein molecules is irradiated with first and second laser light beams having different wavelengths. The molecular composition of the at least two varieties of protein molecules contained in the fluid is measured on the basis of an autocorrelation function of a scattered light signal from the at least two varieties of protein molecules irradiated with the first and second laser light beams having different wavelengths.
    Type: Grant
    Filed: September 22, 2010
    Date of Patent: June 3, 2014
    Assignee: Kowa Company Ltd.
    Inventor: Taisuke Hirono
  • Patent number: 8666465
    Abstract: A device for measuring an analyte concentration level in a subject. The device includes: a light source configured for illuminating at least a portion of an anterior region of an eye of the subject with incident light having a substantially broad illumination spectrum at an angle substantially tangential to the surface of the eye; an optical collector configured for detecting reflected light from the at least a portion of the anterior region of the eye; an analyzer configured for analyzing the detected reflected light; and a processor configured to determine the analyte concentration level in the subject based on the analyzed reflected light.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: March 4, 2014
    Assignee: Chromologic LLC
    Inventor: Naresh Menon
  • Publication number: 20140046151
    Abstract: A method and system perform physiological monitoring. The system includes a first light source and a plurality of optical waveguide couplers, each of the plurality of optical waveguide couplers being arranged at a different predetermined spatial location on an ocular insert to be placed on an eye. The system also includes a plurality of optical waveguides. Each optical waveguide carries light from a second light source to a respective one of the plurality of optical waveguide couplers and carries a received signal from the respective one of the plurality of optical waveguide couplers. A processor receives the received signal from each of the plurality of optical waveguides and monitors a parameter based on the received signal.
    Type: Application
    Filed: August 7, 2012
    Publication date: February 13, 2014
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventor: Douglas M. Gill
  • Patent number: 8639306
    Abstract: An eye-property monitoring system and method for performing the steps of (1) illuminating the eye from at least one light source whose wavelength interacts with internal eye properties in an optically active manner, (2) controlling, to make known and stable, the operating-power/light-output level of the source, (3) by such illuminating, producing light-source eye reflections including (a) multiple internal reflections within the outer structure of the eye, and (b) linked with those internal reflections at least one resulting outbound reflection, (4) monitoring the outbound-reflection to detect therein the reflection level associated with the at least one source, and (5) associating such detected reflection level as an indication of certain eye properties, such as aqueous glucose concentration.
    Type: Grant
    Filed: February 4, 2012
    Date of Patent: January 28, 2014
    Assignee: Brien Holden Vision Diagnostics, Inc.
    Inventor: Tom N. Cornsweet
  • Patent number: 8560033
    Abstract: A sensor for intraocular measurements moveable within at least one of an vitreous humor of an eye, an aqueous humor of an eye and an intraocular replacement medium. The sensor includes a magnetic body susceptible to magnetic fields and at least one sensor film.
    Type: Grant
    Filed: May 18, 2009
    Date of Patent: October 15, 2013
    Assignee: ETH Zurich
    Inventors: Olgac Ergeneman, Karl Vollmers, Jake J. Abbott, Bradley Nelson
  • Publication number: 20130225951
    Abstract: A method and system of acquisition and processing of data representing oxygen saturation (OS) value of a tissue of a visual system of a subject, such as the optic nerve head and overlying artery and vein. The data is acquired at pre-determined discrete spectral points, including at least two isosbestic points, as a discrete reflectance spectrum, with the use of a multi-spectral optical imaging system that simultaneously produces a plurality of two-dimensional spectrally-discrete images by segmenting an incoming light front with secondary objectives. The OS value is assessed based on determination of areas bound by an acquired discrete reflectance spectrum and an isosbestic line.
    Type: Application
    Filed: April 26, 2011
    Publication date: August 29, 2013
    Applicant: EYE02 SCAN LLC
    Inventors: Bahram Khoobehi, Hussein Wafapoor, Alexander M. Eaton, Paul Fournier
  • Publication number: 20130217986
    Abstract: An exemplary method of predicting an amyloidosis status involves obtaining a profile of drusen in a periphery of a retina of a subject; and using the profile to predict an amyloidosis status. Another exemplary method of predicting an amyloidosis status involves identifying a subject, the amyloidosis status of which is desired; and obtaining a profile of drusen in a periphery of a retina of the subject. Another exemplary method of predicting an amyloidosis status involves analyzing a profile of drusen in a periphery of a retina of a subject to predict an amyloidosis status of the subject. Another exemplary method of predicting an amyloidosis status involves comparing a profile of drusen in a periphery of a retina of a subject to a control; and predicting an amyloidosis status of the subject.
    Type: Application
    Filed: February 21, 2013
    Publication date: August 22, 2013
    Applicant: UCL BUSINESS PLC
    Inventor: UCL Business plc
  • Publication number: 20130172700
    Abstract: An method for detection of ?-amyloid in aqueous humor, lens, and retina of eye or the deposit of the combination of ??-crystallin and ?-amyloid in lens is provided. A light is emitted to a testing area in the eye. The light frequency is selected according to an absorption spectrum of the test substance, and the frequency is equal or close to a resonant excitation frequency of one of the electronic molecular energy levels of the substance, so as to excite the substance to generate resonance-enhanced Raman effect or pre-resonance Raman effect to form a detection spectrum. The concentration of the substance could be estimated by a peak intensity of the detection spectrum.
    Type: Application
    Filed: March 21, 2012
    Publication date: July 4, 2013
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Yung-Sung Lan, Chir-Weei Chang
  • Publication number: 20130149714
    Abstract: An implantable diagnostic device in accordance with the present disclosure includes a probe assembly that can be implemented in a variety of ways. A few example implementations include: a needle inside which is located a bio-sensor chip (the needle being insertable into a human being); a compact package containing the bio-sensor chip (the compact package configured for placement inside a catheter); or a silicon-based bio-sensor package configured for insertion into a vein.
    Type: Application
    Filed: December 6, 2012
    Publication date: June 13, 2013
    Applicants: SANOFI AVENTIS, CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: CALIFORNIA INSTITUTE OF TECHNOLOGY, Sanofi Aventis
  • Patent number: 8452361
    Abstract: An ocular sensor (110) is proposed for verification of at least one analyte in an eye fluid. The ocular sensor (110) is composed of at least one sensor material which is designed to change at least one optical characteristic in the presence of the at least one analyte. Furthermore, the ocular sensor (110) comprises at least one sensor chip which has at least one integrated optical detector (122) for verification of the optical characteristic. A measurement system (166) is also proposed for verification of at least one analyte in an eye fluid, which measurement system (166) comprises an ocular sensor (110) according to the invention as well as an evaluation unit (168) which is designed to interchange information with the sensor chip (118).
    Type: Grant
    Filed: January 14, 2008
    Date of Patent: May 28, 2013
    Assignee: Eyesense AG
    Inventor: Achim Müller
  • Patent number: 8452362
    Abstract: A device for measuring a hydration status based on an analyte concentration in a subject. The device includes: a light source configured for illuminating at least a portion of an anterior region of an eye of the subject with incident light having a substantially broad illumination spectrum at an angle substantially tangential to the surface of the eye; an optical collector configured for detecting reflected light from the at least a portion of the anterior region of the eye; an analyzer configured for analyzing the detected reflected light; and a processor configured to determine the analyte concentration level in the subject based on the analyzed reflected light, wherein the processor determines a hydration status of the subject based on the analyte concentration level and reference data.
    Type: Grant
    Filed: January 26, 2010
    Date of Patent: May 28, 2013
    Assignee: Chromologic LLC
    Inventor: Naresh Menon
  • Publication number: 20130131472
    Abstract: A device for measuring an analyte concentration level in a subject. The device includes: a light source configured for illuminating at least a portion of an anterior region of an eye of the subject with incident light having a substantially broad illumination spectrum at an angle substantially tangential to the surface of the eye; an optical collector configured for detecting reflected light from the at least a portion of the anterior region of the eye; an analyzer configured for analyzing the detected reflected light; and a processor configured to determine the analyte concentration level in the subject based on the analyzed reflected light.
    Type: Application
    Filed: January 10, 2013
    Publication date: May 23, 2013
    Applicant: CHROMOLOGIC LLC
    Inventor: Chromologic LLC
  • Patent number: 8433117
    Abstract: An embodiment of the invention provides a method that captures a diagnostic image of a retina having at least one lesion, wherein the lesion includes a plurality of spots to be treated. Information is received from a user interface, wherein the information includes a duration, intensity, and/or wavelength of treatment for each of the spots. A real-time image of the retina is captured; and, a composite image is created by linking the diagnostic image to the real-time image. At least one updated real-time image of the retina is obtained using eye tracking and/or image stabilization; and, an annotated image is created by modifying the composite image based on the updated real-time image. A localized laser beam is delivered to each of the spots according to the information, the composite image, and the annotated image.
    Type: Grant
    Filed: November 21, 2009
    Date of Patent: April 30, 2013
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventor: Henry Hacker
  • Patent number: 8403862
    Abstract: A method includes directing toward a portion of a subject's body a first pulse of electromagnetic energy. While the portion is in a functional state due to the first pulse, a second pulse is directed toward the portion. At a second-pulse time, reflected energy due to the second pulse is detected. While the portion is in a functional state due to the first and second pulses, a third pulse is directed toward the portion. At a third-pulse time, energy of the third pulse, reflected from the portion, is detected. In response to detecting the pulses at the second-pulse time and the third-pulse time, a characteristic of the portion is quantified resulting from (a) the functional state due to the first pulse and (b) the functional state due to the first and second pulses. A clinical state of the subject is identified. Other embodiments are described.
    Type: Grant
    Filed: December 22, 2008
    Date of Patent: March 26, 2013
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Amiram Grinvald, Darin Nelson, Harel Primack
  • Patent number: 8385998
    Abstract: The present invention provides contact lens with integrated biosensor for the continuous, non-invasive monitoring of physiological glucose by employing biocompatible nanostructure-laden lens materials. These contact lenses can be worn by diabetics who can colorimetrically see changes in their contact lens color or other fluorescence-based properties, giving an indication of tear and blood glucose levels. This invention for the glucose biosensor based on the new disposal contact lens provides a safe, convenient and non-expensive glucose sensing device. The sensing device disclosed herein provides an efficient and noninvasive solution for monitoring blood glucose.
    Type: Grant
    Filed: October 26, 2009
    Date of Patent: February 26, 2013
    Inventors: Jin Zhang, William Gerald Hodge
  • Patent number: 8385997
    Abstract: Methods, apparatus, and systems for detecting hemozoin and diagnosing malaria infection are disclosed.
    Type: Grant
    Filed: December 11, 2007
    Date of Patent: February 26, 2013
    Inventors: Roderick A. Hyde, Nathan P. Myhrvold, Clarence T. Tegreene, Lowell L. Wood, Jr.
  • Patent number: 8380270
    Abstract: A device for measuring an analyte concentration level in a subject. The device includes: a light source configured for illuminating at least a portion of an anterior region of an eye of the subject with incident light having a substantially broad illumination spectrum at an angle substantially tangential to the surface of the eye; an optical collector configured for detecting reflected light from the at least a portion of the anterior region of the eye; an analyzer configured for analyzing the detected reflected light; and a processor configured to determine the analyte concentration level in the subject based on the analyzed reflected light.
    Type: Grant
    Filed: January 26, 2010
    Date of Patent: February 19, 2013
    Assignee: Chromologic LLC
    Inventor: Naresh Menon
  • Patent number: 8364218
    Abstract: A method determines the concentration of a substance in a subject's blood. The method includes measuring an interaction of at least one light beam with a portion of the subject's body. The method further includes calculating a value of an optically-measured parameter indicative of the interaction of the at least one light beam with the substance in the portion of the subject's body. The method further includes measuring values of one or more temperature-indicative parameters corresponding to a temperature of the portion of the subject's body. The method further includes accessing an empirical correlation of the optically-measured parameter and the one or more temperature-indicative parameters to concentrations of the substance in blood. The method further includes obtaining a concentration of the substance in the subject's blood using the empirical correlation. The concentration corresponds to the value of the optically-measured parameter and the values of the one or more temperature-indicative parameters.
    Type: Grant
    Filed: February 11, 2008
    Date of Patent: January 29, 2013
    Assignee: GlucoVista, Inc.
    Inventor: Jonathan Gerlitz
  • Patent number: 8364219
    Abstract: An apparatus and method for measuring a concentration of a substance in an eye using a retro-reflected measurement light beam having a first wavelength at which the substance has a non-zero first absorption coefficient and a retro-reflected reference light beam having a second wavelength at which the substance has a second absorption coefficient which is substantially equal to zero. The apparatus further includes a detector positionable to receive the retro-reflected measurement light beam and the retro-reflected reference light beam. The detector is responsive to light having the first wavelength by generating a measurement signal and responsive to light having the second wavelength by generating a reference signal. The apparatus further includes an electrical circuit coupled to the detector. The electrical circuit is responsive to the measurement signal and the reference signal to measure the concentration of the substance in the eye.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: January 29, 2013
    Assignee: Gluco Vista, Inc.
    Inventor: Jonathan Gerlitz
  • Patent number: 8355136
    Abstract: Wearable or implantable devices combining microfluidic control of sample and reagent flow and micro-cavity surface plasmon resonance sensors functionalized with surface treatments or coatings capable of specifically binding to target analytes, ligands, or molecules in a bodily fluid are provided. The devices can be used to determine the presence and concentration of target analytes in the bodily fluids and thereby help diagnose, monitor or detect changes in disease conditions.
    Type: Grant
    Filed: June 13, 2011
    Date of Patent: January 15, 2013
    Assignee: Indiana University Research and Technology Corporation
    Inventors: James A. Glazier, Dragos Amarie
  • Patent number: 8346345
    Abstract: In one aspect the present invention provides methods for assessing a physiological state of a mammalian retina in vivo, the methods of this aspect of the invention each include the steps of (a) irradiating a portion of a mammalian retina, in vivo, with light having a wavelength in the range of from 600 nm to 1000 nm at an intensity sufficient to stimulate two-photon-induced fluorescence in the retina; and (b) assessing a physiological state of the retina by analyzing the fluorescence.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: January 1, 2013
    Assignee: University of Washington
    Inventors: Yoshikazu Imanishi, Krzysztof Palczewski, Bryan S. Sires, Eric J. Seibel
  • Publication number: 20120296180
    Abstract: Methods, apparatus, and systems for detecting hemozoin and diagnosing malaria infection are disclosed.
    Type: Application
    Filed: July 16, 2012
    Publication date: November 22, 2012
    Inventors: Roderick A. Hyde, Nathan P. Myhrvold, Clarence T. Tegreene, Lowell L. Wood, JR.
  • Publication number: 20120268714
    Abstract: A noninvasive method and apparatus for determining analyte concentration (e.g., glucose) in a subject that includes measuring light refraction from at least a portion one or more structures. One example of such structure is the subject's iris.
    Type: Application
    Filed: October 7, 2010
    Publication date: October 25, 2012
    Applicant: UNIVERSITY OF TOLEDO
    Inventors: Brent D. Cameron, Anthony Webb