Hemoglobin Patents (Class 600/320)
  • Patent number: 10013638
    Abstract: A method and system for classifying tissue suspected of being abnormal as being malignant or benign. The method includes generating a set of selection features, performing statistical applications to generate additional selection features, generating a feature vector for the abnormal tissue, feeding the feature vector into a neural network, and obtaining a result from the neural network as to whether the abnormal tissue is malignant or benign. The method and system may be used for determining the presence of breast cancer.
    Type: Grant
    Filed: August 13, 2009
    Date of Patent: July 3, 2018
    Inventors: Ping Zhang, Kuldeep Kumar
  • Patent number: 9852269
    Abstract: A diagnosis support system which performs computer processing of data obtained from an object to be examined and presents the obtained diagnostic information is disclosed. The diagnosis support apparatus includes a diagnosis support processing unit which processes data obtained from the object to extract diagnosis support information, a storage unit which stores the examination history of the object, and a changing unit which changes a processing method in the diagnosis support processing unit in accordance with the examination history of the object stored in the storage unit. In at least one embodiment, diagnosis processing is executed to obtain medical diagnostic information by performing computer processing of data obtained from the object, and the processing method for diagnosis support processing is changed in accordance with the examination history of the object.
    Type: Grant
    Filed: September 9, 2008
    Date of Patent: December 26, 2017
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Yukio Sakagawa, Hiroshi Imamura, Akihiro Katayama, Hiroyuki Shinbata
  • Patent number: 9098743
    Abstract: A fundus image processing apparatus that processes a fundus image of an examinee's eye, the fundus image processing apparatus includes: a processor; and a memory storing computer readable instructions, when executed by the processor, causing the fundus image processing apparatus to: identify the optic disc included in the fundus image; identify a blood vessel included in the fundus image; calculate an upper diameter ratio which is a diameter ratio of those of the identified blood vessels that are positioned in a region above a height of the optic disc; calculate a lower diameter ratio which is a diameter ratio of those of the identified blood vessels that are positioned in a region under the height of the optic disc; and calculate an arteriovenous diameter ratio in the fundus of the examinee's eye based on the upper diameter ratio and the lower diameter ratio.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: August 4, 2015
    Assignees: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, NIDEK CO., LTD.
    Inventors: Susumu Ishida, Kousuke Noda, Michiyuki Saito, Masahiko Kobayashi, Yasuhiro Hoshikawa
  • Publication number: 20140340636
    Abstract: Based on the identification by colorimetry of a colour image of the fundus of the eye of an individual, obtained by specialised cameras (fundus camera or retinograph). The method and the device of the present invention enable establishing a direct relation between the chromatic properties of the various tissues of the optic nerve (10) and the amount of haemoglobin (Hb) in the optic nerve head (10), allowing identification and clearly distinguishing the irrigated regions of the optic nerve (10) from the non-irrigated regions or those with atrophy, constituting a tool of great interest in monitoring and diagnosis of glaucomatous disease and other optic diseases affecting vascularisation. This method also allows taking into account the effect of loss of transparency of the lens in patients with cataracts, as this effect is compensated without affecting the final results of the determination of the amount of haemoglobin (Hb).
    Type: Application
    Filed: November 21, 2012
    Publication date: November 20, 2014
    Inventor: Manuel Gonzalez De La Rosa
  • Patent number: 8396525
    Abstract: A real-time simultaneous measurement apparatus includes: a hemoglobin information-receiving portion that sequentially receives hemoglobin information, which is information relating to the amount of hemoglobin in a head portion of a test subject, from a NIRS brain-measuring apparatus that receives a synchronization signal output by a synchronization signal output apparatus and acquires the hemoglobin information when the synchronization signal has been received; a brain wave information-receiving portion that sequentially receives the brain wave information of the test subject, from an EEG brain wave-measuring apparatus that receives a synchronization signal output by the synchronization signal output apparatus and acquires the brain wave information when the synchronization signal has been received; a synchronization processing portion that performs processing that synchronizes the hemoglobin information and the brain wave information; and an output portion that outputs the synchronized hemoglobin information
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: March 12, 2013
    Assignees: Shimadzu Corporation, Honda Motor Co., Ltd., Advanced Telecommunications Research Institute Research Institute International
    Inventors: Akihiro Ishikawa, Tatsuya Okabe, Masaaki Sato
  • Patent number: 8320981
    Abstract: An implantable system includes light sources to transmit toward vascularized tissue, in a time multiplexed manner, light having a first wavelength of approximately 660 nm, light having a second wavelength of approximately 810 nm, light having a third wavelength of approximately 910 nm, and light having a fourth wavelength of approximately 980 nm. The system includes one or more light detector to detect light of the first, second, third and fourth wavelengths scattered by vascularized tissue. Additionally, one or more processor is configured to determine levels of blood oxygen saturation based on the detected scattered light of the first and third wavelengths, determine levels of tissue oxygen saturation based on the detected scattered light of the first and third wavelengths, determine levels of hemoglobin concentration based on the detected scattered light of the second wavelength, and determine levels of tissue hydration based on the detected scattered light of the second and fourth wavelengths.
    Type: Grant
    Filed: June 29, 2007
    Date of Patent: November 27, 2012
    Assignee: Pacesetter, Inc.
    Inventors: Carl Mayer, Craig Seyl, Joseph Lee Hollmann, Eric Weiss, Lyle Frank Weaver, Timothy A. Fayram
  • Patent number: 7502639
    Abstract: Retinal metabolism is analyzed with a retinal function camera over at least a portion of a cardiac cycle by first illuminating a portion of a retina of an eye 10 with light of a first wavelength and producing a first image. The portion of the retina is subsequently illuminated with light of a second wavelength, the first and second wavelengths being selected such that absorptivity of light of the first wavelength by oxygenated blood is greater than absorptivity of light of the second wavelength and the absorptivity of light of the first wavelength by deoxygenated blood is less than absorptivity of light of the second wavelength, to produce a second image. The first and second images are processed to map relative oxygenation of the portion of the retina as an indication of retinal metabolic function of the portion of the retina.
    Type: Grant
    Filed: June 13, 2005
    Date of Patent: March 10, 2009
    Inventor: Patrick Kerr
  • Publication number: 20080306364
    Abstract: A new model based on ray tracing is developed to estimate power spectral properties in laser Doppler velocimetry of retinal vessels and to predict the effects of laser beam size and eccentricity as well as absorption of laser light by oxygenated and reduced hemoglobin. There is described the model and show that it correctly converges to the traditional rectangular shape of the Doppler shift power spectrum, given the same assumptions, and that reduced beam size and eccentric alignment cause marked alterations in this shape. The changes in the detected total power of the Doppler-shifted light due to light scattering and absorption by blood can also be quantified with this model and may be used to determine the oxygen saturation in retinal arteries and veins. The potential of this approach is that it uses direct measurements of Doppler signals originating only from moving red blood cells. The invention opens new avenues for retinal vessel oximetry.
    Type: Application
    Filed: December 20, 2007
    Publication date: December 11, 2008
    Inventor: Benno L. Petrig
  • Patent number: 7222961
    Abstract: A system and method for detecting a functional signal in retinal images. An optical imaging device comprises a stimulation light source, an interrogating light source, and a detector. The retina is stimulated by the stimulation light source. The retina is then illuminated by an interrogation light, and the reflected intensity from the retina is measured at an interrogating spectral band that indicates the state of hemoglobin saturation before and after visual stimulation. The optical changes that result from retinal neuronal activity are captured by the detector. The signal representing the state of hemoglobin saturation before and after visual stimulation is isolated. In an embodiment of the present invention, this signal is isolated using principle components analysis (PCA).
    Type: Grant
    Filed: July 28, 2003
    Date of Patent: May 29, 2007
    Assignee: Kestrel Corporation
    Inventors: Peter Soliz, Eduardo S. Barriga
  • Patent number: 6939310
    Abstract: Methods and devices are provided for determining a suitable site for sampling physiological fluid. In the subject methods, a potentially suitable physiological sampling site is selected, the fluid flow of the site is characterized and the site is then determined to be suitable based on the whether the site has high or low flow. Suitability may also be determined based on the type of sample obtainable from the site, where the order of the above-described steps may be altered. The subject devices include at least one site flow characterization element for determining the flow characteristics of a potential physiological sampling site and/or at least one sample type characterization element for determining whether the vasculature is arterial, venous or neither, i.e., an interstitial fluid sampling site. The subject methods and devices are particularly suited for use in the detection of physiological sampling sites in the fingers, arms, legs, earlobes, heels, feet, nose and toes.
    Type: Grant
    Filed: October 10, 2001
    Date of Patent: September 6, 2005
    Assignee: LifeScan, Inc.
    Inventors: David Matzinger, Khalid R. Quraishi
  • Patent number: 6831733
    Abstract: The invention concerns a method for quantitative hemoglobin determination in undiluted, unhemolyzed whole blood comprising the steps of: providing a disposable, capillary, which has an optical path length of less than 1 mm; filling said cuvette with a sample of unaltered whole blood; performing a first absorption measurement at a wavelength in the range 490-520 nm directly on the sample in the cuvette, and further conducting a second absorption measurement, and processing results of the first and second absorption measurements to determine the concentration of hemoglobin in the sample, wherein the step of processing comprises compensating for scattering in the sample, said compensating being dependent on the result of the second absorption measurement. A system for implementing the method is also disclosed.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: December 14, 2004
    Assignee: Hemocue AB
    Inventors: Joakim Pettersson, Johnny Svensson
  • Publication number: 20040133085
    Abstract: There is provided a method and a system for determining the concentration of chromophores and reconstructing images in turbid media, such as animal tissues, using a continuous wave optical approach. In particular the approach is based on measurements of attenuation signals and the calculation of concentrations of chromophores using a predetermined scatter law. The system comprises a continuous wave photon migration model calculator coupled to an optical source and detector for estimating concentrations of chromophores and scatter parameters used in image reconstruction.
    Type: Application
    Filed: January 7, 2003
    Publication date: July 8, 2004
    Applicant: ART Advanced Research Technologies Inc.
    Inventor: David J. Hall
  • Patent number: 6701169
    Abstract: A method of determining the autoregulatory status of a subject by obtaining a measurement of a selected parameter of the retinal blood vessels in a non-stimulated subject, administering to the subject a preselected stimulus, obtaining a measurement of the selected parameter of the retinal blood vessels of the subject in response to the administration of the selected stimulus, and determining the ratio of the measurement for the selected parameter in the non-stimulated retinal blood vessels to the measurement of the selected parameter for the retinal blood vessels following the administration of its selected stimulus whereby the ratio provides an indicator of the autoregulatory function or status of the subject.
    Type: Grant
    Filed: November 6, 2001
    Date of Patent: March 2, 2004
    Assignee: The UAB Research Foundation
    Inventor: Kurt R. Denninghoff
  • Patent number: 6611320
    Abstract: The present invention relates to a method for detecting blood characteristics including hemoglobin in a fluid medium using both transmission and reflection of a light beam which forms a quotient.
    Type: Grant
    Filed: September 7, 2000
    Date of Patent: August 26, 2003
    Assignee: OptoQ AB
    Inventors: Lars-Göran Lindberg, Gunnar Enlund, Magnus Vegfors
  • Publication number: 20020173705
    Abstract: A vacuum system for applying vacuum to the body cavity of a patient where a flow switch is provided that is located upstream of a vacuum regulator that can be adjusted to establish the level of vacuum desired to be applied to the patient. The flow switch provides an easy device for the caregiver to activate to fully and positively occlude the vacuum line to the patient. In one embodiment, the flow switch is constructed integral with a regulator having an rotatable actuator having a knob that is rotated to adjust the level of vacuum to the patient such the a caregiver can simply push the actuator knob inwardly to occlude the flow in the patient line and thereafter rotate the actuator knob to establish the desired level of vacuum to the patient.
    Type: Application
    Filed: May 17, 2001
    Publication date: November 21, 2002
    Inventors: Thomas C. Jones, David A. Gloyd
  • Publication number: 20020165439
    Abstract: A device and a method to provide a more reliable and accurate measurement of hematocrit (Hct) by noninvasive means. The changes in the intensities of light of multiple wavelengths transmitted through or reflected light from the tissue location are recorded immediately before and after occluding the flow of venous blood from the tissue location with an occlusion device positioned near the tissue location. As the venous return stops and the incoming arterial blood expands the blood vessels, the light intensities measured within a particular band of near-infrared wavelengths decrease in proportion to the volume of hemoglobin in the tissue location; those intensities measured within a separate band of wavelengths in which water absorbs respond to the difference between the water fractions within the blood and the displaced tissue volume. A mathematical algorithm applied to the time-varying intensities yields a quantitative estimate of the absolute concentration of hemoglobin in the blood.
    Type: Application
    Filed: March 16, 2001
    Publication date: November 7, 2002
    Inventor: Joseph M. Schmitt
  • Patent number: 6124597
    Abstract: The Laser Induced Fluorescence Attenuation Spectroscopy (LIFAS) method and apparatus preferably include a source adapted to emit radiation that is directed at a sample volume in a sample to produce return light from the sample, such return light including modulated return light resulting from modulation by the sample, a first sensor, displaced by a first distance from the sample volume for monitoring the return light and generating a first signal indicative of the intensity of return light, a second sensor, displaced by a second distance from the sample volume, for monitoring the return light and generating a second signal indicative of the intensity of return light, and a processor associated with the first sensor and the second sensor and adapted to process the first and second signals so as to determine the modulation of the sample.
    Type: Grant
    Filed: July 7, 1997
    Date of Patent: September 26, 2000
    Assignee: Cedars-Sinai Medical Center
    Inventors: Ramez E. N. Shehada, Vasilis Z. Marmarelis, Warren S. Grundfest
  • Patent number: 5898487
    Abstract: An apparatus for determining the concentrations of n hemoglobin derivatives in a sample of undiluted, unhemolyzed whole blood provided in a cuvette, employs a device producing a primary light beam formed of at least n substantially monochromatic, narrow-band components of different wavelengths. Further provided is a detection device for measuring of the radiation passing through the cuvette. At least two measuring geometries are provided for spectral detection of a collimated central beam and at least one scatter beam, and detection of the central beam departing from a first measuring location in the cuvette takes place in a first measuring position on the axis of the primary beam, and detection of the scatter beam takes place in a second measuring position if it departs from the first measuring location in the cuvette, or in the first measuring position if it departs from a second measuring location in the cuvette, whereby the axes of the central beam and the scatter beam(s) enclose angles .alpha..sub.
    Type: Grant
    Filed: March 24, 1997
    Date of Patent: April 27, 1999
    Assignee: AVL Medical Instruments AG
    Inventor: Roger Hage
  • Patent number: RE39672
    Abstract: The Laser Induced Fluorescence Attenuation Spectroscopy (LIFAS) method and apparatus preferably include a source adapted to emit radiation that is directed at a sample volume in a sample to produce return light from the sample, such return light including modulated return light resulting from modulation by the sample, a first sensor, displaced by a first distance from the sample volume for monitoring the return light and generating a first signal indicative of the intensity of return light, a second sensor, displaced by a second distance from the sample volume, for monitoring the return light and generating a second signal indicative of the intensity of return light, and a processor associated with the first sensor and the second sensor and adapted to process the first and second signals so as to determine the modulation of the sample.
    Type: Grant
    Filed: January 23, 2002
    Date of Patent: June 5, 2007
    Assignee: Cedars-Sinai Medical Center
    Inventors: Ramez E. N. Shehada, Vasilis Z. Marmarelis, Warren S. Grundfest