Using Fluorescent Emission Determination Patents (Class 600/321)
  • Patent number: 10207108
    Abstract: Described here are systems, devices, and methods for implanting a nasal stimulator into nasal tissue and electrically stimulating nasal tissue. In some variations, a nasal microstimulator implantation system may comprise an implantation tool and an implantable microstimulator. An implantation tool may comprise a shaft and features to releasably attach a microstimulator. A microstimulator may comprise a passive stimulation circuit and one or more electrodes. In other variations, a nasal implantation system may additionally comprise one or more additional devices, such as a controller, an electrical probe, and/or a dissection tool.
    Type: Grant
    Filed: October 22, 2015
    Date of Patent: February 19, 2019
    Assignee: Oculeve, Inc.
    Inventors: Manfred Franke, James Donald Loudin, Janusz Kuzma, Paul Taehyun Yun, Douglas Michael Ackermann
  • Patent number: 9934589
    Abstract: The present invention provides a system and method for determining bilirubin levels in an individual based on skin coloration using a smartphone or other personal device and an attached ancillary apparatus. The device, such as a smartphone or tablet, is capable of storing and running software. The device is also coupled to both a camera and light source to obtain data regarding the skin's coloration. Software is installed on the device to control the light source and calculate bilirubin levels in the individual based on the input received from the camera. The ancillary apparatus is a mechanism surrounding the light source and camera that is placed on the skin of the individual when the system is in use. The ancillary apparatus thus creates a light tight seal between the skin, light source and camera, enabling the system to receive the most accurate data from the camera.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: April 3, 2018
    Assignee: Bilibaby, LLC
    Inventors: Matthew James Clemente, George Stavis, Noureddine Melikechi, Robert Stavis
  • Patent number: 9532712
    Abstract: An ophthalmoscope having a laser device for laser irradiation of an eye, in particular for performing a photocoagulation on fundus of the eye of the eye, includes an illuminator for illuminating the eye as well as a camera for acquiring an image of the eye. The illuminator is adapted to generate visible and infrared lights. The ophthalmoscope further includes a control unit adapted to trigger the illuminator for generating a light pulse of visible light and to read out from the camera a control image of the eye acquired by the camera during the light pulse. The ophthalmoscope is configurable to acquire an image of an eye and perform a laser treatment of an eye.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: January 3, 2017
    Assignee: OD-OS GmbH
    Inventors: Ben Liesfeld, Winfried Teiwes, Ulrike Weber, Kay-Uwe Amthor, Stephan Kirsch
  • Patent number: 9066682
    Abstract: Provided is a fundus imaging apparatus including a wavefront adjuster and a detector. The wavefront adjuster is configured to adjust a wavefront of a femtosecond pulsed laser beam incident on an ocular fundus to be examined. The detector is configured to detect fluorescence generated in a multi-photon excitation process by the femtosecond pulsed laser beam incident on the ocular fundus to be examined. The wavefront adjuster is further configured to adjust the wavefront so that an intensity of the fluorescence to be detected by the detector becomes a maximum value.
    Type: Grant
    Filed: February 16, 2012
    Date of Patent: June 30, 2015
    Assignee: Sony Corporation
    Inventors: Takuya Kishimoto, Sakuya Tamada
  • Publication number: 20150065824
    Abstract: Ophthalmic devices with media inserts that have fluorescence based analysis elements upon or within them may be utilized to analyze and monitor fluid for certain components. Methods and devices for active ophthalmic devices based on fluorescence based analysis elements may also be formed. More specifically, the fluorescence based analysis elements may be useful for analyzing an analyte such as glucose in a fluid sample.
    Type: Application
    Filed: August 28, 2013
    Publication date: March 5, 2015
    Applicant: Johnson & Johnson Vision Care, Inc.
    Inventors: Randall Braxton Pugh, Frederick A. Flitsch
  • Publication number: 20140357969
    Abstract: In a laser scanning method for measuring in vivo substances, wavelength of the anti-Stokes line is made greater than wavelength absorption band of the specific substance, the wavelength of the probe light is shifted from the wavelength of the anti-Stokes line by a shift amount of Raman scattering of the specific substance, and the wavelength of the Stokes light is shifted from the wavelength of the probe light by the shift amount of the Raman scattering of the specific substance. According to this, density (concentration and distribution) of lutein in an eye fundus is measured quantitatively and non-invasively from a signal strength level of the anti-Stokes line.
    Type: Application
    Filed: December 17, 2012
    Publication date: December 4, 2014
    Inventors: Satoshi Wada, Kazuo Tsubota, Atsushi Shinjo
  • Patent number: 8515514
    Abstract: Provided is a method of calibrating a pulse oximeter, in which the effects caused by tissue of a subject can be taken into account. A detector output signal is measured when living tissue of the subject is present between emitters and the detector in a sensor. Nominal calibration and nominal calibration characteristics are read from a memory, whereupon values for the same nominal characteristics for the sensor on living tissue of the subject are established using the detector output signal. Then, changes in the nominal calibration characteristics induced by the living tissue are calculated and a subject-specific calibration is formed by correcting the nominal calibration with the changes. Finally, the hemoglobin fractions are solved using the corrected nominal calibration.
    Type: Grant
    Filed: September 18, 2008
    Date of Patent: August 20, 2013
    Assignee: Datex-Ohmeda, Inc.
    Inventor: Matti Huiku
  • Publication number: 20130197326
    Abstract: Disclosed herein are compositions comprising an oblong optode sensing agent. The oblong optode sensing agent comprises a core and a semipermeable membrane, wherein the core comprises one or more sensors configured to bind to an analyte. In addition, methods of making and detecting the oblong optode sensing agents are disclosed.
    Type: Application
    Filed: September 10, 2012
    Publication date: August 1, 2013
    Applicant: NORTHEASTERN UNIVERSITY
    Inventors: John Matthew DUBACH, Heather A. CLARK, Karen K. GLEASON, Gozde OZAYDIN-INCE
  • Patent number: 8494605
    Abstract: A noninvasive blood component measuring device configured so as to resolve the variance of measuring results depend on the fixing position to the living body. Concretely, a non-invasive blood component measuring device comprising a light source section for illuminating a living body which includes a blood vessel, an imaging section for imaging the living body illuminated by the light source, and a controller is disclosed. The controller includes a memory under control of a processor.
    Type: Grant
    Filed: February 11, 2009
    Date of Patent: July 23, 2013
    Assignee: Sysmex Corporation
    Inventors: Yasuhito Ohnishi, Toshiyuki Ozawa
  • Publication number: 20130135580
    Abstract: In accordance with an embodiment of the invention, there is provided a device and method for detecting an amyloid protein in an eye of a mammal. A method comprises illuminating the eye with a light source having at least one of a wavelength property, a polarization property or a combination thereof, each appropriate to produce fluorescence in at least an amyloid-binding compound when the amyloid-binding compound is bound to the amyloid protein, the amyloid-binding compound having been introduced to the eye and specifically binding to the amyloid protein indicative of the amyloidogenic disorder; and determining a time decay rate of fluorescence for at least the fluorescence produced by the amyloid-binding compound bound to the amyloid protein, the determining permitting distinguishing of the presence of the amyloid-binding compound bound to the amyloid protein in the eye based on at least the time decay rate.
    Type: Application
    Filed: August 12, 2011
    Publication date: May 30, 2013
    Inventors: Paul D. Hartung, Vincent Valvo, Charles Kerbage, Gerald D. Cagle, Dennis J. Nilan
  • Patent number: 8406837
    Abstract: A functionalized tip is incorporated into catheters for the cytometric delivery of cells into the brain and other body parts. For use in the brain, the tip forms part of a neurosurgical probe having a proximal end and a distal end. In addition to the functionalized tip, the probe has at least one cell slurry delivery lumen and a plurality of optical fibers configured along the probe, terminating in the tip to provide the photo-optical capability needed to monitor the viability and physiological behavior of the grafted cells as well as certain characteristics of the cellular environment. Details are also presented of the use of a neurocatheter having a cytometric tip of the type disclosed in the invention, as employed within the context of a feedback and control system for regulating the number of cells delivered to the brain of a patient.
    Type: Grant
    Filed: November 1, 2007
    Date of Patent: March 26, 2013
    Assignees: UT-Battelle, LLC, University of Virginia Patent Foundation
    Inventors: George T. Gillies, Helen Fillmore, William C. Broaddus, Boyd M. Evans, III, Stephen W. Allison
  • Publication number: 20120203086
    Abstract: Apparatus and methods for spectroscopic analysis of biological tissues to classify an individual as diabetic or non-diabetic, or to determine the probability, progression or level of a disease or medical condition in an individual.
    Type: Application
    Filed: November 7, 2011
    Publication date: August 9, 2012
    Applicant: FREEDOM MEDITECH, INC.
    Inventors: Dale A. RORABAUGH, Neil M. DAVIS, Vincent F. BRANCACCIO, Paul WILLIAMS
  • Patent number: 8131333
    Abstract: This invention is generally related to a biocompatible sensor for detecting/measuring sugar, especially glucose, in an ocular fluid in a non-invasive or minimally invasive manner and a method for using the biocompatible sensor. A biocompatible sensor of the invention comprises, consists essentially, or consists of an ophthalmic device comprising a molecular sensing moiety which interacts or, reacts with sugar to provide an optical signal which is indicative of sugar level in an ocular fluid.
    Type: Grant
    Filed: August 6, 2004
    Date of Patent: March 6, 2012
    Assignee: EyeSense AG
    Inventors: L. Lawrence Chapoy, Angelika Maria Domschke, Dawn Smith
  • Publication number: 20110040161
    Abstract: Utilization of a contact device placed on the eye in order to detect physical and chemical parameters of the body as well as the non-invasive delivery of compounds according to these physical and chemical parameters, with signals being transmitted continuously as electromagnetic waves, radio waves, infrared and the like. One of the parameters to be detected includes non-invasive blood analysis utilizing chemical changes and chemical products that are found in the conjunctiva and in the tear film. A transensor mounted in the contact device laying on the cornea or the surface of the eye is capable of evaluating and measuring physical and chemical parameters in the eye including non-invasive blood analysis. The system utilizes eye lid motion and/or closure of the eye lid to activate a microminiature radio frequency sensitive transensor mounted in the contact device. The signal can be communicated by wires or radio telemetered to an externally placed receiver.
    Type: Application
    Filed: July 8, 2010
    Publication date: February 17, 2011
    Inventor: Marcio Marc Abreu
  • Publication number: 20110028807
    Abstract: Utilization of a contact device placed on the eye in order to detect physical and chemical parameters of the body as well as the non-invasive delivery of compounds according to these physical and chemical parameters, with signals being transmitted continuously as electromagnetic waves, radio waves, infrared and the like. One of the parameters to be detected includes non-invasive blood analysis utilizing chemical changes and chemical products that are found in the conjunctiva and in the tear film. A transensor mounted in the contact device laying on the cornea or the surface of the eye is capable of evaluating and measuring physical and chemical parameters in the eye including non-invasive blood analysis. The system utilizes eye lid motion and/or closure of the eye lid to activate a microminiature radio frequency sensitive transensor mounted in the contact device. The signal can be communicated by wires or radio telemetered to an externally placed receiver.
    Type: Application
    Filed: July 8, 2010
    Publication date: February 3, 2011
    Inventor: Marcio Marc Abreu
  • Patent number: 7877135
    Abstract: An image data processor comprising an image signal receiver, a histogram generator, a gain calculator, an amplifier, and a signal feeder, is provided. The image signal receiver receives an autofluorescence image signal. The autofluorescence image signal is generated by an imaging device when the imaging device captures an autofluorescence image. The histogram generator generates a histogram of luminance in the autofluorescence image based on the autofluorescence image signal. The gain calculator calculates a gain based on the histogram and a predetermined luminance value. The amplifier amplifies the autofluorescence image signal by the gain. And then the amplifier generates an amplified autofluorescence image signal. The signal feeder outputs the amplified autofluorescence image signal to a monitor. The monitor displays an amplified autofluorescence image.
    Type: Grant
    Filed: February 13, 2006
    Date of Patent: January 25, 2011
    Assignee: Hoya Corporation
    Inventors: Kohei Iketani, Mitsufumi Fukuyama
  • Patent number: 7787940
    Abstract: An image data processor comprising an image signal receiver, a histogram generator, a gain calculator, an amplifier, and a signal feeder, is provided. The image signal receiver receives an autofluorescence image signal. The autofluorescence image signal is generated by an imaging device when the imaging device captures an autofluorescence image. The histogram generator generates a histogram of luminance in the autofluorescence image based on the autofluorescence image signal. The gain calculator calculates a gain based on the histogram and a predetermined luminance value. The amplifier amplifies the autofluorescence image signal by the gain. And then the amplifier generates an amplified autofluorescence image signal. The signal feeder outputs the amplified autofluorescence image signal to a monitor. The monitor displays an amplified autofluorescence image.
    Type: Grant
    Filed: February 13, 2006
    Date of Patent: August 31, 2010
    Assignee: Hoya Corporation
    Inventors: Kohei Iketani, Mitsufumi Fukuyama
  • Patent number: 7653424
    Abstract: An apparatus for measuring ocular and/or blood glucose levels comprises (a) an irradiating means (10) for irradiating light onto the eye (1) of a user from outside the cornea of the eye to excite an ocular glucose sensor in contact with an ocular fluid, said sensor being able to emit a total fluorescence having first and a second wavelength bands; (b) an optical path splitting means (11) for splitting said total fluorescence into a first fluorescence and a second fluorescence, said first fluorescence and said second fluorescence traveling along first and second optical paths; (c) a first detecting means (14) located in the first optical path; (d) a second detecting means (17) located in the second optical path; (e) a calculating means for calculating the intensity ratio of the first fluorescence to the second fluorescence and for determining an ocular glucose concentration in the ocular fluid; and (f) an arithmetic means for converting the ocular glucose concentration into a blood glucose concentration.
    Type: Grant
    Filed: March 16, 2006
    Date of Patent: January 26, 2010
    Assignee: Eyesense AG
    Inventor: Wayne Front March
  • Patent number: 7406345
    Abstract: The present invention relates to a hand-held fluorescence photometer and method for measuring an analyte level, preferably a blood glucose level, from an ocular fluid. The photometer is based on a dual beams measuring system and it is capable of defining the correct positioning for the measurement. Only when the apparatus is correctly positioned the actual analyte measurement automatically takes place.
    Type: Grant
    Filed: February 13, 2004
    Date of Patent: July 29, 2008
    Assignee: Eyesense AG
    Inventors: Achim Müller, Roland Schmieder, Klaus Haberstroh
  • Publication number: 20080160079
    Abstract: A capsule medication administration system includes: a first capsule for internal body marking; a second capsule for medication; a marking device which makes a marking within a living body; a drug retention section which retains a drug; a release device which releases the drug; a detection device which detects the marking; a decision device which decides whether or not a marking which has been detected by the detection device is a specified marking; and a release control device which operates the release devices if it has been decided by the decision device that it is the specified marking; wherein the first capsule comprises the marking device. The second capsule comprises the drug retention section and the release device.
    Type: Application
    Filed: February 1, 2008
    Publication date: July 3, 2008
    Applicant: OLYMPUS CORPORATION
    Inventors: Hironobu Takizawa, Akio Uchiyama, Hidetake Segawa, Masahiro Takata, Hideki Koyanagi
  • Patent number: 7229175
    Abstract: An ophthalmic image sensing apparatus includes an examination optical system for examining an eye to be examined, an image sensing optical system for sensing an image of the eye to be examined, an examination image pickup element for picking up the image of the eye to be examined through the examination optical system, an image-sensing image pickup element for picking up the image of the eye to be examined through the image sensing optical system, an examination condition setting device for determining image sensing states of the examination optical system and the examination image pickup element, and a driving device for determining image sensing states of the image sensing optical system and the image-sensing image pickup element based on the examination conditions determined by the examination condition setting device.
    Type: Grant
    Filed: January 20, 2006
    Date of Patent: June 12, 2007
    Assignee: Canon Kabushiki Kaisha
    Inventor: Hiroshi Itoh
  • Patent number: 6980842
    Abstract: An ophthalmic lens comprising a receptor moiety can be used to determine the amount of an analyte in an ocular fluid. The receptor moiety can bind either a specific analyte or a detectably labeled competitor moiety. The amount of detectably labeled competitor moiety which is displaced from the receptor moiety by the analyte is measured and provides a means of determining analyte concentration in an ocular fluid, such as tears, aqueous humor, or interstitial fluid. The concentration of the analyte in the ocular fluid, in turn, indicates the concentration of the analyte in a fluid or tissue sample of the body, such as blood or intracellular fluid.
    Type: Grant
    Filed: October 11, 2002
    Date of Patent: December 27, 2005
    Assignee: Novartis
    Inventors: Wayne Front March, Mary Flowers Mowery-McKee
  • Patent number: 6850786
    Abstract: An ophthalmic lens comprising a receptor moiety can be used to determine the amount of an analyte in an ocular fluid. The receptor moiety can bind either a specific analyte or a detectably labeled competitor moiety. The amount of detectably labeled competitor moiety which is displaced from the receptor moiety by the analyte is measured and provides a means of determining analyte concentration in an ocular fluid, such as tears, aqueous humor, or interstitial fluid. The concentration of the analyte in the ocular fluid, in turn, inidicates the concentration of the analyte in a fluid or tissue sample of the body, such as blood or intracellular fluid.
    Type: Grant
    Filed: September 3, 2003
    Date of Patent: February 1, 2005
    Assignee: Novartis AG
    Inventor: Wayne Front March
  • Patent number: 6687534
    Abstract: A fluorescent-light image display apparatus for displaying on a monitor a fluorescent-light image emitted from a target area irradiated by a excitation light. A photo-detector inputs the output value of the excitation light into an irregularity controller, which determines whether or not the output of the excitation light is smaller than a set value. If the output of the excitation light is determined to be larger than the set value, an irregularity detection signal is output to the main controller. The main controller stops the flow of drive-current to and the emission of excitation light from the GaN semiconductor laser, and displays a message on the monitor that an irregularity has occurred in the output of the excitation light when the output of the excitation light is larger than a predetermined value, the emission of the excitation light is stopped and the patient is not irradiated by excitation light having an energy density above a predetermined value.
    Type: Grant
    Filed: August 1, 2001
    Date of Patent: February 3, 2004
    Assignee: Fuji Photo Film Co., Ltd.
    Inventor: Kazuhiro Tsujita
  • Patent number: 6681127
    Abstract: An ophthalmic lens comprising a receptor moiety can be used to determine the amount of an analyte in an ocular fluid. The receptor moiety can bind either a specific analyte or a detectably labeled competitor moiety. The amount of detectably labeled competitor moiety which is displaced from the receptor moiety by the analyte is measured and provides a means of determining analyte concentration in an ocular fluid, such as tears, aqueous humor, or interstitial fluid. The concentration of the analyte in the ocular fluid, in turn, indicates the concentration of the analyte in a fluid or tissue sample of the body, such as blood or intracellular fluid.
    Type: Grant
    Filed: February 15, 2001
    Date of Patent: January 20, 2004
    Assignee: Novartis AG
    Inventor: Wayne Front March
  • Publication number: 20030216626
    Abstract: A CCD imaging element obtains a narrow band image and a wide band image from fluorescence emitted from a subject upon the irradiation by an excitation light. A reflectance image is obtained of light reflected from the subject upon the irradiation by a near-infrared light. A fluorescence value computing means obtains a normalized fluorescence computed value by dividing the value of each pixel of the narrow band image by that of the corresponding pixel of the wide band image, and obtains a computed fluorescence yield rate by dividing each pixel value of the wide band image by the corresponding pixel value of the reflectance image. A judging portion judges the tissue state of the subject based on the two-dimensional distribution point of the two aforementioned computed values and prerecorded computed value distribution data of normalized fluorescence computed values and computed fluorescence yield rates for tissues having known tissue states.
    Type: Application
    Filed: March 28, 2003
    Publication date: November 20, 2003
    Applicant: FUJI PHOTO FILM CO., LTD.
    Inventors: Kazuhiro Tsujita, Eiji Ogawa
  • Publication number: 20030158471
    Abstract: An apparatus for evaluating a function of an autonomic nerve of a living subject, including a heart-rate measuring device which iteratively measures a heart rate of the subject, a cuff-pressure changing device which changes a pressure in a first cuff adapted to be wound around an inferior limb of the subject, and a pressure in a second cuff adapted to be wound around a superior limb of the subject, so as to press the inferior and superior limbs, and a dispersion-degree determining device for determining a first degree of dispersion of the heart-rate values iteratively measured by the heart-rate measuring device after the cuff-pressure changing device starts pressing the inferior and superior limbs.
    Type: Application
    Filed: October 15, 2002
    Publication date: August 21, 2003
    Applicant: COLIN CORPORATION
    Inventors: Kiyoyuki Narimatsu, Toshihiko Ogura, Akira Tampo
  • Patent number: 6554775
    Abstract: Absolute volumetric blood flow of the ocular fundus is quantified using video frames of fluorescent particles circulating in the retina and choroid. An optical apparatus is used to identify movements of particles in a passage of interest, and methods are provided for associating the individual particle movements with a blood flow rates so that absolute flow rates can be quantified.
    Type: Grant
    Filed: November 21, 2000
    Date of Patent: April 29, 2003
    Inventors: Gholam Peyman, Bahram Khoobehi
  • Publication number: 20020151774
    Abstract: A non-invasive spectral measurement of a native, diagnostic or treatment component in blood or tissue, illuminates the back of the eye and collects return light that has passed through and been reflected from choroidal or retinal tissue. Spectral analysis detects a retinal tissue state, or detects the level of a blood or serum constituent, which may be a native constituent or a dye, marker or pharmacological agent. Time-resolved or spectral decay monitoring may be used to assess organ functioning, e.g., by administering a serum-carried indicator of uptake, clearance or binding rate for specific organs. Circulating cells or material diagnostic of different conditions may also be detected by spectral analysis, either directly, or by tagging with a suitable label.
    Type: Application
    Filed: February 28, 2002
    Publication date: October 17, 2002
    Applicant: UMASS/WORCESTER
    Inventors: Babs R. Soller, Bilal Saleh, Edward Chaum, Markus E. Testorf, Michael Fiddy
  • Patent number: 6438398
    Abstract: A method of evaluating clearance of fluorescein dye instilled into tear film having a greater sensitivity and specificity for diagnosing a tear film disorder as the cause of a patient's ocular irritation and ocular surface disease than can be achieved using the traditional methods. The inventive method can be performed using a diagnostic kit for evaluating tear fluorescence clearance in which the concentration of tear fluorescein is visually quantified via a color standard.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: August 20, 2002
    Assignee: The University of Miami
    Inventors: Stephen C. Pflugfelder, Scheffer C. G. Tseng, Adolfo Afonso, Angelo Macri
  • Publication number: 20010034500
    Abstract: An ophthalmic lens comprising a receptor moiety can be used to determine the amount of an analyte in an ocular fluid. The receptor moiety can bind either a specific analyte or a detectably labeled competitor moiety. The amount of detectably labeled competitor moiety which is displaced from the receptor moiety by the analyte is measured and provides a means of determining analyte concentration in an ocular fluid, such as tears, aqueous humor, or interstitial fluid. The concentration of the analyte in the ocular fluid, in turn, indicates the concentration of the analyte in a fluid or tissue sample of the body, such as blood or intracellular fluid.
    Type: Application
    Filed: February 15, 2001
    Publication date: October 25, 2001
    Inventor: Wayne Front March
  • Patent number: 6178340
    Abstract: A novel three-dimensional infrared imager for study of the vascular network so as to cause blood vessels to be visualized for accurate subcutaneous puncture during insertion of a hypodermic needle. The invention uses the properties of near infrared light as it is absorbed and reflected by the human body, allowing the user to visualize the tissues a few millimeters in depth from the skin's surface. The use of infrared light permits the manipulation of the acquired information to a grade of sensed visualization, which is impossible to reach with visible light. The invention imitates the human three-dimensional perception by use of a stereoscopic infrared viewer, and is designed to be user friendly, allowing the health care professional to work in his usual manner. A double image is superimposed on the viewer and the user wears blue-red eyeglasses to create the three-dimensional image from the double image on the viewer.
    Type: Grant
    Filed: August 24, 1998
    Date of Patent: January 23, 2001
    Inventor: Eduardo Svetliza
  • Patent number: 6124597
    Abstract: The Laser Induced Fluorescence Attenuation Spectroscopy (LIFAS) method and apparatus preferably include a source adapted to emit radiation that is directed at a sample volume in a sample to produce return light from the sample, such return light including modulated return light resulting from modulation by the sample, a first sensor, displaced by a first distance from the sample volume for monitoring the return light and generating a first signal indicative of the intensity of return light, a second sensor, displaced by a second distance from the sample volume, for monitoring the return light and generating a second signal indicative of the intensity of return light, and a processor associated with the first sensor and the second sensor and adapted to process the first and second signals so as to determine the modulation of the sample.
    Type: Grant
    Filed: July 7, 1997
    Date of Patent: September 26, 2000
    Assignee: Cedars-Sinai Medical Center
    Inventors: Ramez E. N. Shehada, Vasilis Z. Marmarelis, Warren S. Grundfest
  • Patent number: RE39672
    Abstract: The Laser Induced Fluorescence Attenuation Spectroscopy (LIFAS) method and apparatus preferably include a source adapted to emit radiation that is directed at a sample volume in a sample to produce return light from the sample, such return light including modulated return light resulting from modulation by the sample, a first sensor, displaced by a first distance from the sample volume for monitoring the return light and generating a first signal indicative of the intensity of return light, a second sensor, displaced by a second distance from the sample volume, for monitoring the return light and generating a second signal indicative of the intensity of return light, and a processor associated with the first sensor and the second sensor and adapted to process the first and second signals so as to determine the modulation of the sample.
    Type: Grant
    Filed: January 23, 2002
    Date of Patent: June 5, 2007
    Assignee: Cedars-Sinai Medical Center
    Inventors: Ramez E. N. Shehada, Vasilis Z. Marmarelis, Warren S. Grundfest