Abstract: OCT imaging systems are provided for imaging a spherical-type eye including a source having an associated source arm path and a reference arm having an associated reference arm path coupled to the source path. The reference arm path has an associated reference arm path length. A sample is also provided having an associated sample arm path coupled to the source arm and reference arm paths. A lens having a focal power optimized for a diameter of the spherical-type eye is provided along with a reference arm path length adjustment module coupled to the reference arm. The reference arm path length adjustment module is configured to automatically adjust the reference arm path length such that the reference arm path length is based on an eye diameter of the subject.

Abstract: OCT imaging systems are provided for imaging a spherical-type eye including a source having an associated source arm path and a reference arm having an associated reference arm path coupled to the source path. The reference arm path has an associated reference arm path length. A sample is also provided having an associated sample arm path coupled to the source arm and reference arm paths. A lens having a focal power optimized for a diameter of the spherical-type eye is provided along with a reference arm path length adjustment module coupled to the reference arm. The reference arm path length adjustment module is configured to automatically adjust the reference arm path length such that the reference arm path length is based on an eye diameter of the subject.

Abstract: OCT imaging systems are provided for imaging a spherical-type eye including a source having an associated source arm path and a reference arm having an associated reference arm path coupled to the source path. The reference arm path has an associated reference arm path length. A sample is also provided having an associated sample arm path coupled to the source arm and reference arm paths. A lens having a focal power optimized for a diameter of the spherical-type eye is provided along with a reference arm path length adjustment module coupled to the reference arm. The reference arm path length adjustment module is configured to automatically adjust the reference arm path length such that the reference arm path length is based on an eye diameter of the subject.

Abstract: Measuring oxygen concentration and monitoring changes in oxygen concentration within an enclosed space by applying a transmembrane photoluminescent oxygen probe to the external surface of the membrane forming the enclosed space, wherein the transmembrane photoluminescent oxygen probe has an oxygen impermeable support layer carrying a spot of an oxygen-sensitive photoluminescent dye and a layer of a pressure-sensitive adhesive on a first major surface of the support layer.

Abstract: A system for cleaning up and preparing an image for segmentation is disclosed. An image transmitting device is configured to transmit a first image to an image receiving device. The image receiving device is configured to: receive the first image; apply a Dual Tree Complex Wavelet transform to the first image to form a plurality of sub-images; generate a high pass image based on the plurality of sub-images; generate a rotational invariant resultant image based on the high pass image; generate a low pass image based on the plurality of sub-images; and combine the rotational invariant resultant image and the low pass image to form a pseudo-fluorescent image.

Abstract: Vessel perfusion and myocardial blush are determined by analyzing fluorescence signals obtained in a static region-of-interest (ROI) in a collection of fluorescence images of myocardial tissue. The blush value is determined from the total intensity of the intensity values of image elements located within the smallest contiguous range of image intensity values containing a predefined fraction of a total measured image intensity of all image elements within the ROI. Vessel (arterial) peak intensity is determined from image elements located within the ROI that have the smallest contiguous range of highest measured image intensity values and contain a predefined fraction of a total measured image intensity of all image elements within the ROI. Cardiac function can be established by comparing the time differential between the time of peak intensity in a blood vessel and that in a region of neighboring myocardial tissue both pre and post procedure.

Abstract: Apparatus for detecting intracranial temperature and blood oxygenation includes a transducer having a working surface for placement against a patient's cranium. The transducer forms a microwave antenna having walls defining an aperture having a pair of opposite broader boundaries and a pair of opposite narrower boundaries at the working surface. The antenna is tuned to a frequency which produces a first output signal indicative of heat emanating from the cranium. An oxygen saturation sensor sharing that aperture includes a radiation emitter located at one of narrower boundaries which directs electromagnetic radiation across the aperture to a radiation detector at the other of the narrower boundaries and which produces a corresponding second output signal. A control unit includes a display and a processor for processing the signals to calculate an intracranial temperature and an oxygen saturation value for display by the control unit.

Abstract: A method of determining the functional activity of the MRP2 and/or MRP3 efflux pathway of a human or animal subject was disclosed. The method comprises (i) determining the level of a bile acid derivative in the blood of said human or animal subject at a predetermined time interval after introducing an amount of the bile acid derivative into the subject, and (ii) using the determination obtained in step (i) to indicate the functional activity of the MRP2 and/or MRP3 efflux pathway of the subject.

Abstract: This invention provides devices, compositions and methods for determining the concentration of one or more metabolites or analytes in a biological sample, including cells, tissues, organs, organisms, and biological fluids. In particular, this invention provides materials, apparatuses, and methods for several non-invasive techniques for the determination of in vivo blood glucose concentration levels based upon the in vivo measurement of one or more biologically active molecules found in skin.

Abstract: Vessel perfusion and myocardial blush are determined by analyzing fluorescence signals obtained in a static region-of-interest (ROI) in a collection of fluorescence images of myocardial tissue. The blush value is determined from the total intensity of the intensity values of image elements located within the smallest contiguous range of image intensity values containing a predefined fraction of a total measured image intensity of all image elements within the ROI. Vessel (arterial) peak intensity is determined from image elements located within the ROI that have the smallest contiguous range of highest measured image intensity values and contain a predefined fraction of a total measured image intensity of all image elements within the ROI. Cardiac function can be established by comparing the time differential between the time of peak intensity in a blood vessel and that in a region of neighboring myocardial tissue both pre and post procedure.

Abstract: In one aspect a method of determining the functional activity of the MRP2 and/or MRP3 efflux pathway of a human or animal subject, comprises: (i) determining the level of a bile acid derivative in the blood of said human or animal subject at a predetermined time interval after introducing an amount of the bile acid derivative into the subject; and (ii) using the determination obtained in step (i) to indicate the functional activity of the MRP2 and/or MRP3 efflux pathway of the subject.

Abstract: The present invention relates, in general, to a system for analyzing tissue perfusion using the concentration of indocyanine green and a method of measuring the perfusion rate using the system and, more particularly, to a system for measuring tissue perfusion by injecting indocyanine green into a living body, detecting variation in the concentration of indocyanine green with the passage of time, and analyzing the detected variation, and a method of measuring the perfusion rate using the system. The present invention provides a method of measuring perfusion in a living body, which enables accurate measurement for respective regions in a wide range from a perfusion rate decreased to less than 10% of normal perfusion to a perfusion rate increased to greater than normal perfusion using the above-described mechanism of ICG in a living body, which cannot be conducted using the conventional technology.

Abstract: An image data processor comprising an image signal receiver, a histogram generator, a gain calculator, an amplifier, and a signal feeder, is provided. The image signal receiver receives an autofluorescence image signal. The autofluorescence image signal is generated by an imaging device when the imaging device captures an autofluorescence image. The histogram generator generates a histogram of luminance in the autofluorescence image based on the autofluorescence image signal. The gain calculator calculates a gain based on the histogram and a predetermined luminance value. The amplifier amplifies the autofluorescence image signal by the gain. And then the amplifier generates an amplified autofluorescence image signal. The signal feeder outputs the amplified autofluorescence image signal to a monitor. The monitor displays an amplified autofluorescence image.

Abstract: An image data processor comprising an image signal receiver, a histogram generator, a gain calculator, an amplifier, and a signal feeder, is provided. The image signal receiver receives an autofluorescence image signal. The autofluorescence image signal is generated by an imaging device when the imaging device captures an autofluorescence image. The histogram generator generates a histogram of luminance in the autofluorescence image based on the autofluorescence image signal. The gain calculator calculates a gain based on the histogram and a predetermined luminance value. The amplifier amplifies the autofluorescence image signal by the gain. And then the amplifier generates an amplified autofluorescence image signal. The signal feeder outputs the amplified autofluorescence image signal to a monitor. The monitor displays an amplified autofluorescence image.

Abstract: An optical examination technique employs an optical system for in vivo non-invasive examination of breast tissue of a subject. The optical system includes an optical module, a controller and a processor. The optical module includes an array of optical input ports and optical detection ports located in a selected geometrical pattern to provide a multiplicity of photon migration paths inside the biological tissue. Each optical input port is constructed to introduce into the examined tissue visible or infrared light emitted from a light source. Each optical detection port is constructed to provide light from the tissue to a light detector. The controller is constructed and arranged to activate one or several light sources and light detectors so that the light detector detects light that has migrated over at least one of the photon migration paths.

Abstract: An optical examination technique employs an optical system for in vivo non-invasive transcranial examination of brain tissue of a subject. The optical system includes an optical module arranged for placement on the exterior of the head, a controller and a processor. The optical module includes an array of optical input ports and optical detection ports located in a selected geometrical pattern to provide a multiplicity of photon migration paths inside the biological tissue. Each optical input port is constructed to introduce into the examined tissue visible or infrared light emitted from a light source. Each optical detection port is constructed to provide light from the tissue to a light detector. The controller is constructed and arranged to activate one or several light sources and light detectors so that the light detector detects light that has migrated over at least one of the photon migration paths.

Abstract: Methods and devices for Laser Induced Fluorescence Attenuation Laser Induced Fluorescence Attenuation Spectroscopy (LIFAS) Spectrocopy, including, in particular, methods and devices for the detection of ischemia and hypoxia in biological tissue.

Abstract: Body function measuring apparatus which provides: (1) an indication of the body function being measured, and (2) a loose probe condition by determining that the difference between the rate of change of a first body function signal, developed by a first sensor in the probe, and the rate of change of a second body function signal, developed by a second sensor in the probe, exceeds a predetermined threshold.