Determining Blood Constituent Patents (Class 600/322)
  • Patent number: 10321115
    Abstract: A three-dimensional (3D) depth sensor may include: a plurality of light sources configured to irradiate light to an object, the light having different center wavelengths; an optical shutter configured to allow reflected light reflected from the object to pass through; and an image sensor configured to filter the reflected light having passed through the optical shutter and detect the filtered light.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: June 11, 2019
    Inventors: Weiming Li, Mingcai Zhou, Ya Lu, Chun Wang, Myungjae Jeon
  • Patent number: 10299724
    Abstract: A wristwatch includes a case containing electronic components of the wristwatch. An optoelectronic module including at least one light emitting element and at least one light sensing element is disposed within the case or within a fastener for the wristwatch. The optoelectronic module is operable to obtain physiological data of a person wearing the wristwatch by using the light emitting element and the light sensing element.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: May 28, 2019
    Assignee: ams Sensors Singapore Pte. Ltd.
    Inventor: Ohad Meitav
  • Patent number: 10282839
    Abstract: A variation of a method for estimating a quantity of a blood component in a fluid canister includes: within an image of a canister, identifying a reference marker on the canister; selecting an area of the image based on the reference marking; correlating a portion of the selected area with a fluid level within the canister; estimating a volume of fluid within the canister based on the fluid level; extracting a feature from the selected area; correlating the extracted featured with a concentration of a blood component within the canister; and estimating a quantity of the blood component within the canister based on the estimated volume and the concentration of the blood component within the canister.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: May 7, 2019
    Assignee: Gauss Surgical, Inc.
    Inventors: Siddarth Satish, Ali Zandifar, Kevin J. Miller
  • Patent number: 10258265
    Abstract: The present disclosure relates to noninvasive methods, devices, and systems for measuring various blood constituents or analytes, such as glucose. In an embodiment, a light source comprises LEDs and super-luminescent LEDs. The light source emits light at least wavelengths of about 1610 nm, about 1640 nm, and about 1665 nm. In an embodiment, the detector comprises a plurality of photodetectors arranged in a special geometry comprising one of a substantially linear substantially equal spaced geometry, a substantially linear substantially non-equal spaced geometry, and a substantially grid geometry.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: April 16, 2019
    Inventors: Jeroen Poeze, Marcelo Lamego, Sean Merritt, Cristiano Dalvi, Hung Vo, Johannes Bruinsma, Ferdyan Lesmana, Massi Joe E. Kiani, Greg Olsen
  • Patent number: 10247666
    Abstract: A detector has a sensor responsive to a first wavelength, a sensor responsive to a second wavelength, and a sensor for collecting reference readings. A gas sample is analyzed to obtain readings corresponding to the first wavelength, the second wavelength and a reference. A first absorption figure is calculated using the first reading and the reference reading, and a second absorption figure using the second reading and the reference reading. A linearizer function is applied to the first and second absorption figures to calculate first and second concentration figures. The sensor for each wavelength is calibrated for detecting the first gas such that the data collected at each wavelength gives the same reading when only the first gas is present. The ratio of the first concentration figure to the second concentration figure is used to identify whether only the first gas is present.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: April 2, 2019
    Assignee: Gas Measurement Instruments Limited
    Inventors: Crawford Massie, Fraser Mathieson, Andrew Glendinning
  • Patent number: 10241034
    Abstract: A concentration measurement method accurately, quickly, and non-destructively measures the concentration of a predetermined chemical component within an object to a nano-order trace concentration level in real time. A time sharing method irradiates the object light of a first wavelength and light of a second wavelength having different light absorption rates with respect to the object to be measured. Light of both wavelengths that arrives optically through the object is received by a shared light reception sensor, and signals respectively relating to light of the first and second wavelengths are output from the light reception sensor in accordance with the received light. A differential signal of these signals is formed, and the concentration of a chemical component in the object to be measured is derived on the basis of the differential signal.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: March 26, 2019
    Inventors: Shigetoshi Sugawa, Rihito Kuroda
  • Patent number: 10231670
    Abstract: Systems and methods are disclosed for proximity sensing in physiological sensors, and more specifically to using one or more proximity sensors located on or within a physiological sensor to determine the positioning of the physiological sensor on a patient measurement site. Accurate placement of a physiological sensor on the patient measurement site is a key factor in obtaining reliable measurement of physiological parameters of the patient. Proper alignment between a measurement site and a sensor optical assembly provides more accurate physiological measurement data. This alignment can be determined based on data from a proximity sensor or sensors placed on or within the physiological sensor.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: March 19, 2019
    Inventors: Thomas B. Blank, Gregory A. Olsen, Cristiano Dalvi, Hung T. Vo
  • Patent number: 10219746
    Abstract: An embodiment of the present disclosure seeks to select characteristics of incoming intensity data that cause comparisons of selected characteristics to produce defined probe off space having reduced crossover with defined probe on space. Once defined, the present disclosure compares characteristics of incoming intensity data with the now defined probe off space, and in some embodiments, defined probe on space, to determine whether a probe off condition exists. When a processor determines a probe off condition exists, the processor may output or trigger an output signal that audibly and/or visually indicates to a user that the optical sensor should be adjusted for a proper application to a measurement site.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: March 5, 2019
    Assignee: Masimo Corporation
    Inventors: Ryan Timothy McHale, Walter M. Weber
  • Patent number: 10132792
    Abstract: Disclosed herein are portable diagnostic measurement devices for determining at least one analysis parameter of a bodily fluid, in particular for determining an analyte concentration in a bodily fluid as can occur in blood glucose determinations. Also disclosed are analysis systems including the measurement device and at least one disposable test element. The test element can be designed as a carrier strip and can contact a receiving surface of the measurement device at least partially in a flat manner, where the receiving surface is arranged on a narrow side of the housing of the measurement device.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: November 20, 2018
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Heino Eikmeier, Hans-Peter Haar, Joachim Hoenes, Carina Horn, Ewald Rieger
  • Patent number: 10085679
    Abstract: A system and method for detecting vascular contamination by surgical anesthetic using non-invasive IR spectrophotometry. One embodiment is a method for operating an instrument such as an enhanced pulse oximeter to monitor a patient receiving local anesthetic marked with dye that absorbs infrared light. Light is applied to and detected from tissue of the patient. A signal representative of the detected light is processed to derive patient oxygenation information. The detected light is also processed to derive information representative of the presence of the dye-marked anesthetic. The oxygenation information and the information representative of the presence of anesthetic are displayed. The oxygenation monitoring and display and the anesthetic monitoring and display can occur separately or concurrently. Fluorescing dyes and fluorescence detection approaches are used for anesthetic detection in some embodiments.
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: October 2, 2018
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Steven R. Clendenen, Clifton R. Haider, Barry K. Gilbert, Oliver William Spees
  • Patent number: 10048114
    Abstract: In a device for measuring the vibrational amplitude of a capillary tube of a wire bonder, the capillary tube is placed between a light source and a detector system, so that the vibrational amplitude is able to be ascertained from the shading of a beam of light by the capillary tube. The beam of light emitted by the light source is split into a measuring beam of light and a reference beam of light, an edge of the capillary tube at least partially shading the measuring beam of light in the vibrating state, while the reference beam of light is not shaded. The detector system includes a measuring detector assigned to the measuring beam of light as well as at least one reference detector assigned to the reference beam of light, and the vibrational amplitude of the capillary tube is ascertainable from the interconnected output signals of the measuring detector and the reference detector.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: August 14, 2018
    Inventors: Walter Huber, Wolfgang Holzapfel
  • Patent number: 10039491
    Abstract: Optical measurement of physiological parameters with wearable devices often includes measuring signals in the presence of significant noise sources. These noise sources include, but are not limited to, noise associated with: variable optical coupling to skin or tissue, variations in tissue optical properties with time due to changes in humidity, temperature, hydration, variations in tissue optical properties between individuals, variable coupling of ambient light sources into detectors, and instrument and detector noise, including electrical noise, radio frequency or magnetic interference, or noise caused by mechanical movement of the detector or its components. The present disclosure includes devices and methods configured to produce representations of the raw data in which noise, broadly defined, is separated from the data of interest. The disclosed devices and methods may include subtracting or calibrating out these noise sources and other spurious fluctuations in wearable devices with optical sensors.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: August 7, 2018
    Assignee: Verily Life Sciences LLC
    Inventors: Jason Donald Thompson, Vikram Singh Bajaj, Victor Marcel Acosta, Tamara Lynn Troy
  • Patent number: 10022089
    Abstract: The invention relates to a device and a method for noninvasive measurement of parameters of a bodily tissue, the measuring device having a sensor unit and a sensor mat for detachable placement of the device on a body surface. The sensor unit (1) has a receptacle (6), the interior of which accommodates a sensor arrangement, wherein the receptacle (6) has a sensor surface (15) in the direction of the body surface. The sensor mat (8) has a cutout (11) for accommodating the sensor unit (1) and a contact surface (14), at least partially surrounding the sensor unit (1), for placement on the body surface (9). A cover (12) is provided for closing the cutout (11) over an upper side of the sensor unit (1) and the sensor mat (8) during a measurement of parameters. The sensor unit (1), the sensor mat (8) and the cover (12) are detachable from one another.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: July 17, 2018
    Assignee: Luciole Medical AG
    Inventors: Christophe Lechot, Jean-Claude Frely, Marcel Aeschlimann, Juerg Hans Froehlich, Dirk Baumann, Markus Hugo Muser, Michael Oberle
  • Patent number: 10004410
    Abstract: The present invention relates generally to a system and methods for measuring physiological parameters. More specifically, the present invention relates to a noncontact technology by which one or more physiological parameters of a subject may be efficiently and quickly detected. Among other advantages, the present invention can be used to assess and monitor vital signs of one or more subjects in a variety of contexts including for medical or security triage purposes, for use in healthcare waiting rooms, as part of human imaging systems, or during surgery.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: June 26, 2018
    Assignees: The Board of Trustees of the University of Illinois, The University of North Carolina at Chapel Hill
    Inventors: Stephen W. Porges, Maria I. Davila, Gregory F. Lewis
  • Patent number: 9996758
    Abstract: A biometric sensor apparatus for capturing patterns of blood vessels on the inner side of a wrist. The sensor apparatus has a strap with a near infrared camera mounted on a part of the strap. The camera is arranged for capturing an image of the blood vessels when it is temporarily held at an increased distance from the wrist than when the apparatus is simply being worn by the user. In some embodiments the camera is held at the required position for capturing the images of the blood vessels when the wrist strap is being opened or closed. In some embodiments the camera may be mounted in a deployant clasp of the wrist strap.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: June 12, 2018
    Assignee: Biowatch SA
    Inventors: Joseph Rice, Matthias Vanoni
  • Patent number: 9976989
    Abstract: A monitoring system includes an acoustic emission monitoring system including acoustic emission sensors, a partial discharge monitoring system including partial discharge sensors and synchronized with the acoustic emission monitoring system, and a computer receiving acoustic emission data from the acoustic emission sensors and electrical data from the partial discharge sensors. The computer is configured to classify a first statistical event as a fatigue cracking event by pattern recognition of the acoustic emission data and determine a first location and a first damage condition resulting from the fatigue cracking event, classify a second statistical event as a partial discharge event by pattern recognition of the acoustic emission data or the electrical data, and fuse the acoustic emission data and the electrical data for the second statistical event and determine a second location and a second damage condition resulting from the partial discharge event. Methods of monitoring are also disclosed.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: May 22, 2018
    Assignee: General Electric Company
    Inventors: Ehsan Dehghan Niri, Curtis Wayne Rose, Andrew Batton Witney
  • Patent number: 9943240
    Abstract: A non-invasive method for determining the tissue perfusion state in a patient, by measuring the variations in the skin CO2 pressure and in the perfusion index of the patient during the conducting of a localized hyperthermia test.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: April 17, 2018
    Assignee: Assistance Publique—Hopitaux de Paris
    Inventors: Fabrice Vallee, Joaquim Mateo, Didier Payen De La Garanderie
  • Patent number: 9936905
    Abstract: A device for detection or measurement of a carbohydrate analyte in fluid comprises: an optical sensor comprising components of an assay for carbohydrate analyte, the readout of which is a detectable or measurable optical signal, and a light guide having a distal portion optically coupled to the assay components and a proximal portion; and a reader for interrogating the optical sensor, the reader comprising an assay interrogating system including a lens; and an interface portion forming part of at least one of the optical sensor and the reader, the interface portion being capable of removably constraining the proximal portion of the light guide and the lens of the assay interrogating system in an optically coupled arrangement. The device may be combined with an insulin-infusion system.
    Type: Grant
    Filed: October 13, 2014
    Date of Patent: April 10, 2018
    Assignee: Medtronic MiniMed, Inc.
    Inventors: Eric Allan Larson, Voltaire Isaac Lebron, Kevin Holz, Jasson Rodriguez, Ameya Kantak, Soren Aasmul
  • Patent number: 9883808
    Abstract: Provided are a photo-acoustic imaging apparatus and a method of displaying a photo-acoustic image by the photo-acoustic imaging apparatus. The method of displaying a photo-acoustic image by a photo-acoustic imaging apparatus includes: obtaining a first reception signal, which converts a first acoustic wave generated as light having a first wavelength is absorbed by a subject, and a second reception signal, which converts a second acoustic wave generated as light having a second wavelength is absorbed by the subject; determining a first correction coefficient for the first reception signal and a second correction coefficient for the second reception signal based on a ratio between a size of the first reception signal and that of the second reception signal; and displaying a photo-acoustic image which is corrected based on the first and second correction coefficients.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: February 6, 2018
    Inventors: Dal-Kwon Koh, Jung-Taek Oh, Jung-Ho Kim, Jong-Kyu Jung
  • Patent number: 9877686
    Abstract: This disclosure describes, among other features, systems and methods for using multiple physiological parameter inputs to determine multiparameter confidence in respiratory rate measurements. For example, a patient monitoring system can programmatically determine multiparameter confidence in respiratory rate measurements obtained from an acoustic sensor based at least partly on inputs obtained from other non-acoustic sensors or monitors. The patient monitoring system can output a multiparameter confidence indication reflective of the programmatically-determined multiparameter confidence. The multiparameter confidence indication can assist a clinician in determining whether or how to treat a patient based on the patient's respiratory rate.
    Type: Grant
    Filed: June 26, 2015
    Date of Patent: January 30, 2018
    Inventors: Ammar Al-Ali, Bilal Muhsin, Michael O'Reilly
  • Patent number: 9870625
    Abstract: A method and system for communicating estimated blood loss parameters of a patient to a user, the method comprising: receiving data representative of an image, of a fluid receiver; automatically detecting a region within the image associated with a volume of fluid received at the fluid receiver, the volume of fluid including a blood component; calculating an estimated amount of the blood component present in the volume of fluid based upon a color parameter represented in the region, and determining a bias error associated with the estimated amount of the blood component; updating an analysis of an aggregate amount of the blood component and an aggregate bias error associated with blood loss of the patient, based upon the estimated amount of the blood component and the bias error; and providing information from the analysis of the aggregate amount of the blood component and the aggregate bias error, to the user.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: January 16, 2018
    Assignee: Gauss Surgical, Inc.
    Inventors: Siddarth Satish, Andrew T. Hosford, Kevin J. Miller, Milton McColl, Juan Carlos Aragon
  • Patent number: 9861305
    Abstract: A method and an apparatus for separating a composite signal into a plurality of signals is described. A signal processor receives a composite signal and separates a composite signal into separate output signals. Feedback from one or more of the output signals is provided to a configuration module that configures the signal processor to improve a quality of the output signals. In one embodiment, calibration data from multiple calibration data sets is used to configure the demodulation of the composite signal into separate output signals.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: January 9, 2018
    Assignee: Masimo Corporation
    Inventors: Walter M. Weber, Ammar Al-Ali, Mohamed K. Diab, Marcelo M. Lamego
  • Patent number: 9833179
    Abstract: A blood component is accurately analyzed by appropriately extracting a blood-vessel transmitted light component. In a blood component analyzing apparatus, a sensor section has a light-emitting section that irradiates light from a predetermined irradiation position situated over a blood vessel and a light-receiving section including a first photodetector that receives light at a first light-receiving position that is different from the irradiation position and is situated over the blood vessel and a second photodetector that receives light at a second light-receiving position that is not situated over the blood vessel. A spectrum synthesizing section synthesizes a first light-reception result at the first light-receiving position and a second light-reception result at the second light-receiving position by performing a predetermined synthesis process based on a positional relationship among the irradiation position, first light-receiving position, and second light-receiving position.
    Type: Grant
    Filed: December 24, 2014
    Date of Patent: December 5, 2017
    Assignee: Seiko Epson Corporation
    Inventor: Akira Ikeda
  • Patent number: 9808188
    Abstract: The present disclosure describes the derivation and measurement of a fractional oxygen saturation measurement.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: November 7, 2017
    Inventors: Philip Perea, Ammar Al-Ali, Massi Joe E. Kiani
  • Patent number: 9808197
    Abstract: According to one embodiment, a wearable electronic apparatus detects movement of a human body wearing the apparatus. The apparatus causes a first number of light emitters to emit light when a magnitude of the detected movement is less than a first value. The first number of light emitters is among a plurality of light emitters which emit light having different wavelengths, in which the light are received by a light receiver to obtain physiological information. The apparatus causes a second number greater than the first number of light emitters among the plurality of light emitters to emit light when the magnitude of the detected movement is greater than or equal to the first value.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: November 7, 2017
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Takaya Matsuno, Takashi Sudo, Yasuhiro Kanishima
  • Patent number: 9788787
    Abstract: The present invention is a Miniature Vein Enhancer that includes a Miniature Projection Head. The Miniature Projection Head may be operated in one of three modes, AFM, DBM, and RTM. The Miniature Projection Head of the present invention projects an image of the veins of a patient, which aids the practitioner in pinpointing a vein for an intravenous drip, blood test, and the like. The Miniature projection head may have a cavity for a power source or it may have a power source located in a body portion of the Miniature Vein Enhancer. The Miniature Vein Enhancer may be attached to one of several improved needle protectors, or the Miniature Vein Enhancer may be attached to a body similar to a flashlight for hand held use. The Miniature Vein Enhancer of the present invention may also be attached to a magnifying glass, a flat panel display, and the like.
    Type: Grant
    Filed: May 6, 2015
    Date of Patent: October 17, 2017
    Assignee: AccuVein, Inc.
    Inventors: Ron Goldman, David Hunt, Mark Mock, Graham Marshall, Stephen P Conlon, Robert Roth
  • Patent number: 9743881
    Abstract: Functional imaging for localization in biological tissue entails measuring a response in the tissue (240) to electromagnetic radiation. A catheter (200) for real-time monitoring of cardiac ablation is employed to distinguish a hemorrhage zone (232) from the sandwiching necrotic and healthy tissue, or to distinguish exogenous photoacoustic contrast agent from bordering native tissue. A pair of wavelengths is selected for differential absorption (244) of the radiation in, correspondingly, the hemorrhage zone or where the contrast agent exists, and relatively similar absorption elsewhere. Near infrared laser or LED light may be used photoacoustically to serially acquire (S310, S320) the two datasets to be compared, each representative of a time waveform. Alternatively, acquisition is for a pair of wavelength bands of microwave-induced thermoacoustic data.
    Type: Grant
    Filed: March 27, 2012
    Date of Patent: August 29, 2017
    Assignee: Koninklijke Philips N.V.
    Inventors: Emil Radulescu, Sheng-Wen Huang, Ramon Erkamp, Ladislav Jankovic, Yan Shi, Khalid Shahzad
  • Patent number: 9734304
    Abstract: Apparatuses and methods are disclosed for identifying with a single, small, intelligent activity monitor a particular type of activity from among a plurality of different activities. The monitor may include a multi-axis accelerometer and microcontroller configured to combine and process accelerometer data so as to generate features representative of an activity. The features may be processed to identify a particular activity (e.g., running, biking, swimming) from among a plurality of different activities that may include activities not performed by a human subject. An intelligent activity monitor may be configured to operate as a versatile sensor, or to operate in combination with a versatile sensor, to further receive and process physiological data and compute a fitness metric for a subject.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: August 15, 2017
    Assignee: LUMIRADX UK LTD
    Inventors: Thomas P. Blackadar, David P. Monahan
  • Patent number: 9668703
    Abstract: A patient monitor for displaying a physiological signal can include a visual element having a middle portion indicative of a transition in the physiological signal between physiological states. The visual element can also include first and second extremity portions, the first extremity portion extending from the middle portion in a first direction and the second extremity portion extending from the middle portion in a second direction. The visual element can also include an actionable value indicator to specify a value about the middle portion and the first and second extremity portions. The patient monitor can also include a processor configured to cause the value indicator to actuate in both the first and second directions according to changes in the physiological signal.
    Type: Grant
    Filed: July 28, 2014
    Date of Patent: June 6, 2017
    Assignee: Masimo Corporation
    Inventor: Ammar Al-Ali
  • Patent number: 9668682
    Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: June 6, 2017
    Assignee: DexCom, Inc.
    Inventors: Mark C. Brister, Jack Pryor, John Nolting, Jacob S. Leach, Luis Pestana, Nelson Quintana, Vance Swanson, Paul V. Goode, Jr., James Patrick Thrower
  • Patent number: 9642538
    Abstract: A health care band operably attaches a biosensor to a patient. The biosensor includes one or more sensors for collecting vitals of a patient and a wireless transmitter that is configured to communicate with an EMR network that stores and maintains an EMR of the patient. The biosensor stores a unique identification associated with the patient's EMR such that vitals measured by the biosensor may be transmitted with the patient's unique identification for storage in the patient's EMR. The sensors in the biosensor may include a thermometer, motion detector/accelerometer, pulse detector and oximeter, etc. In an embodiment, one of the sensors in the biosensor includes a photoplethysmography (PPG) based sensor that may be configured to continuously or periodically measure a patient's vitals, such as heart rate, pulse, blood oxygen levels, blood glucose or insulin levels, or other blood analytics in vitro.
    Type: Grant
    Filed: September 25, 2016
    Date of Patent: May 9, 2017
    Assignee: Sanmina Corporation
    Inventor: Robert Steven Newberry
  • Patent number: 9603561
    Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration.
    Type: Grant
    Filed: April 24, 2014
    Date of Patent: March 28, 2017
    Inventors: Andrea Varsavsky, Xiaolong Li, Mike C. Liu, Yuxiang Zhong, Ning Yang
  • Patent number: 9591975
    Abstract: A noninvasive physiological sensor for measuring one or more physiological parameters of a medical patient can include a bump interposed between a light source and a photodetector. The bump can be placed in contact with body tissue of a patient and thereby reduce a thickness of the body tissue. As a result, an optical pathlength between the light source and the photodetector can be reduced. In addition, the sensor can include a heat sink that can direct heat away from the light source. Moreover, the sensor can include shielding in the optical path between the light source and the photodetector. The shielding can reduce noise received by the photodetector.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: March 14, 2017
    Inventors: Cristiano Dalvi, Marcelo Lamego, Sean Merritt, Hung Vo, Johannes Bruinsma, Jeroen Poeze, Ferdyan Lesmana, Greg Olsen, Massi Joe E. Kiani
  • Patent number: 9594020
    Abstract: Blood separation systems and methods are provided for controlling the interface between separated blood components. The system includes a centrifuge assembly having a light-transmissive portion, a light reflector, and a fluid processing region therebetween. An optical sensor system emits a scanning light beam along a path toward the light-transmissive portion, which transmits at least a portion of the scanning light beam to the fluid processing region and the light reflector. The light reflector reflects at least a portion of the scanning light beam toward the optical sensor system along a path substantially coaxial to the path of the scanning light beam from the optical sensor system toward the light-transmissive portion of the centrifuge assembly. The scanning light beam may be a white light beam or narrow spectrum beam. The reflected beam may be directed through the optical sensor system via optical fibers.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: March 14, 2017
    Assignee: Fenwal, Inc.
    Inventors: Peter David Koudelka, Ryan Eliot Eckman, Eric Karl Lindmark, Lubomir Koudelka, James Joseph Ulmes, Steven R. Katz, William H. Cork
  • Patent number: 9572534
    Abstract: Devices, systems, methods and kits for releasably mounting a medical device on the body or skin of a user are provided.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: February 21, 2017
    Inventor: Gary Ashley Stafford
  • Patent number: 9566027
    Abstract: A medical device is presented for reduced-pain blood sampling and testing. The device comprises a housing defining a finger site for supporting a user's finger or a portion thereof within said finger site during the device operation; piercing, sampling and testing assemblies sequentially actuatable to successively initiate piercing, sampling and testing operational modes of the device; a carriage at least partially accommodated within said housing and being adapted for movement with respect to said finger site between its first position corresponding to the piercing mode of the device and a second position corresponding to the sampling and testing modes of the device, the device being thereby capable of operating in the piercing, sampling and testing modes while at a static position of the user's finger.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: February 14, 2017
    Assignee: RAPIDX LTD.
    Inventor: Nili Tamir
  • Patent number: 9562851
    Abstract: The present invention relates to a method for controlling a spectrometer for analyzing a product, the spectrometer including a light source including several light-emitting diodes having respective emission spectra covering in combination an analysis wavelength band, the method including steps of: supplying at least one of the light-emitting diodes with a supply current to switch it on, measuring a light intensity emitted by the light source by measuring a current at a terminal of at least another of the light-emitting diodes maintained off, determining, according to each light intensity measurement, a setpoint value of the supply current of each diode that is on, and regulating the supply current of each diode that is on so that it corresponds to the setpoint value.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: February 7, 2017
    Assignee: SP3H
    Inventors: Sylvain Oberti, Johan Fournel
  • Patent number: 9562850
    Abstract: A method for controlling a spectrometer for analyzing a product includes steps of: acquiring a measurement representative of the operation of a light source, determining, depending on the measurement, a value of supply current of the light source, and/or a value of integration time of light-sensitive cells of a sensor, disposed on a route of a light beam emitted by the light source and having interacted with a product to be analyzed, and if the integration time and/or supply current value is between threshold values, supplying the light source with a supply current corresponding to the determined supply current value, adjusting the integration time of a light-sensitive cell to the determined integration time value, and acquiring light intensity measurements supplied by the sensor, enabling a spectrum to be formed.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: February 7, 2017
    Assignee: SP3H
    Inventors: Sylvain Oberti, Johan Fournel
  • Patent number: 9538943
    Abstract: The invention is an improved blood glucose monitor and method of use thereof, comprising the combination of a noninvasive blood glucose detector with a blood sample reader for invasively obtained samples and a monitor for tracking blood glucose concentrations over time. The invention enables real time calibration of noninvasive blood glucose detection for continuous monitoring.
    Type: Grant
    Filed: October 31, 2011
    Date of Patent: January 10, 2017
    Inventors: William Howard Cross, Frank Russell Denton, III
  • Patent number: 9538946
    Abstract: A system is provided for monitoring glucose in a host, including a continuous glucose sensor that produces a data stream indicative of a host's glucose concentration and an integrated receiver that receives the data stream from the continuous glucose sensor and calibrates the data stream using a single point glucose monitor that is integral with the integrated receiver. The integrated receiver obtains a glucose value from the single point glucose monitor, calibrates the sensor data stream received from the continuous glucose sensor, and displays one or both of the single point glucose measurement values and the calibrated continuous glucose sensor values on the user interface.
    Type: Grant
    Filed: March 25, 2010
    Date of Patent: January 10, 2017
    Assignee: DexCom, Inc.
    Inventors: Andrew Rasdal, James H. Brauker, Paul V. Neale, Peter C. Simpson
  • Patent number: 9504391
    Abstract: A system and method to determine pulse transit time using a handheld device. The method includes generating an electrocardiogram (EKG) for a user of the handheld device. Two portions of the user's body are in contact with two contact points of the handheld device. The method also includes de-noising the EKG to identify a start time when a blood pulse leaves a heart of the user. The method further includes de-noising a plurality of video images of the user to identify a pressure wave indicating an arterial site and a time when the pressure wave appears. Additionally, the method includes determining the PTT based on the de-noised EKG and the de-noised video images.
    Type: Grant
    Filed: March 4, 2013
    Date of Patent: November 29, 2016
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: Daniel Morris, T. Scott Saponas, Desney S. Tan, Morgan Dixon, Siddharth Khullar, Harshvardhan Vathsangam
  • Patent number: 9489816
    Abstract: Portable patient monitoring systems are provided that include profiles that can be selectively overwritten with profiles stored in or otherwise accessible by docking stations that can mate with the portable patient monitoring systems. Related apparatus, systems, techniques and articles are also described.
    Type: Grant
    Filed: July 31, 2012
    Date of Patent: November 8, 2016
    Assignee: Drägerwerk AG & Co. KGaA
    Inventors: Richard Faucette, Jason Braley
  • Patent number: 9480422
    Abstract: A pulse oximetry sensor comprises emitters configured to transmit light having a plurality of wavelengths into a fleshy medium. A detector is responsive to the emitted light after absorption by constituents of pulsatile blood flowing within the medium so as to generate intensity signals. A sensor head has a light absorbing surface adapted to be disposed proximate the medium. The emitters and the detector are disposed proximate the sensor head. A detector window is defined by the sensor head and configured so as to limit the field-of-view of the detector.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: November 1, 2016
    Inventor: Ammar Al-Ali
  • Patent number: 9480407
    Abstract: A device and method for removal of ambient noise signal from a photoplethysmographic measurement is provided. The method comprises obtaining a first signal waveform based on detecting light based on a first light illumination; obtaining a second signal waveform based on detecting light based on a second light illumination; tuning the first light and second light illumination such that the maximum amplitudes of the first and second signal waveforms are maximized and within a predetermined saturation range, such that ambient light interference for the first and second signal waveforms is reduced; obtaining a third signal waveform based on detecting ambient light; obtaining respective maximum and minimum values of the first and the second signal waveforms; and deriving signal values of the first and second signal waveforms with the removal of ambient noise by subtracting AC and DC average values of the third signal waveform from the first and second signals.
    Type: Grant
    Filed: January 5, 2012
    Date of Patent: November 1, 2016
    Inventors: Senthil Kumar, Md. Irwan bin Md. Kassim, Kittipong Kasamsook, Mohamad Sulhede Bin Samsudin, Visit Thaveeprungsriporn
  • Patent number: 9445756
    Abstract: An integrated lancing test strip includes a test strip and a lancet packet coupled to the test strip. The lancet packet includes a sterility sheet enclosing a lancet to maintain the sterility of the lancet and prevent cross-contamination between the test strip and the lancet. The sterility sheet allows the lancet to be sterilized separately from the test strip. The sterility sheet gives the integrated strip a low profile, which is attractive for packaging multiple integrated strips in cassettes, drums, magazines or the like. In one form, the integrated strip is loaded in a meter that includes an adjustment mechanism that adjusts the position of the test strip relative to the skin being sampled. This allows the user to adjust the position of the test strip so as to not apply excessive pressure against skin, which could hamper bleeding from the incision in the skin.
    Type: Grant
    Filed: September 22, 2010
    Date of Patent: September 20, 2016
    Assignee: Roche Diabetes Care, Inc.
    Inventor: Steven N. Roe
  • Patent number: 9445759
    Abstract: A blood glucose calibration system has a noninvasive sensor that attaches to a person's tissue site so as to generate multi-stream physiological data responsive to that person's blood constituents. Composite parameters, each in the form of a mathematical combination of invasive blood panel parameters, are derived from a general population and are responsive to the multi-stream physiological data. A population-based, blood glucose estimate for that person is derived from a weighted and scaled combination of these composite parameters. An individualized blood glucose estimate is then derived from the population-based blood glucose estimate and intermittent invasive test strip measurements of that particular individual.
    Type: Grant
    Filed: December 24, 2012
    Date of Patent: September 20, 2016
    Inventors: Marcelo M. Lamego, Massi Joe E. Kiani, Jesse Chen, Mathew Paul, Hoi Wong
  • Patent number: 9439588
    Abstract: An implantable fluorescent concentrator is configured to be inserted in vivo as a subcutaneous light source for optical absorption spectroscopy of surface-near tissue layers. As a result, certain and reliable results of the optical absorption spectroscopy are achievable. Furthermore, various analytes with different absorption properties are certainly and reliably quantifiable.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: September 13, 2016
    Assignee: Robert Bosch GmbH
    Inventor: Ingo Ramsteiner
  • Patent number: 9398870
    Abstract: A system includes an enclosure having a processor and a memory coupled to the processor. The enclosure includes a display coupled to the processor where the display is visible from an exterior of the enclosure; and a battery within the enclosure coupled to the processor and the display. The enclosure includes a probe tip coupled to an exterior of the enclosure. The probe tip includes first, second, and third sensor openings. A first distance between the first and second sensor openings is different than a second distance between the first and third sensor openings. The enclosure includes code stored in the memory where the code is executable by the processor, and includes code to receive first data associated with the first and second sensor openings, code to receive second data associated with the first and second sensor openings, and code to perform SRS using the first and the second data.
    Type: Grant
    Filed: August 12, 2013
    Date of Patent: July 26, 2016
    Assignee: ViOptix, Inc.
    Inventors: Kate LeeAnn Bechtel, Joseph Heanue, Lester John Lloyd, Edward Solomon
  • Patent number: 9380942
    Abstract: A metabolite concentration is measured in vivo using Raman spectroscopy in such a way as to receive at a detector (229) light scattered from the metabolite in interstitial fluid in skin in a measurement location (217) at a depth (218) of from 200-300 ?m below the skin surface providing improved retention of correct calibration and transferability of calibration between individual subjects.
    Type: Grant
    Filed: July 5, 2012
    Date of Patent: July 5, 2016
    Assignee: RSP SYSTEMS A/S
    Inventors: Morten Henneberg, Stefan Ovesen Banke, Anders Weber
  • Patent number: 9345434
    Abstract: A physiological signal measurement apparatus is capable of automatically adjusting a measure position and suitable for installed on a support element to measure a physiological signal of a user. The physiological signal measurement apparatus includes a movable element, a physiological signal sensing element, a pressure sensing unit and a microcontroller unit. The movable element has a first pressure. The user exerts a second pressure on the physiological signal sensing element, and exerts a third pressure on the support element. The pressure sensing unit senses the first pressure, the second pressure and the third pressure to generate a first pressure signal, a second pressure signal and a third pressure signal. The microcontroller unit receives the physiological signals and the pressure signals, and controls the movable element by the pressure signals and the physiological signals, in order to increase the quality of signal measurement.
    Type: Grant
    Filed: June 23, 2014
    Date of Patent: May 24, 2016
    Assignee: National Taiwan University of Science and Technology
    Inventors: Yuan-Hsiang Lin, Chong-Rong Wu