Determining Blood Constituent Patents (Class 600/322)
  • Patent number: 11096592
    Abstract: A sensor module includes a light emitter that emits light beams including near-infrared light beams towards a subject; a light receiver that receives light beams having passed through the subject; and a controller that estimates biological information based on signals output from the light receiver. The light emitter includes a plurality of light emitting elements that emit near-infrared light beams having central wavelengths different from each other. The light emitter produces sets of light emissions by causing the plurality of light emitting elements to sequentially and intermittently emit the near-infrared light beams. In given two consecutive sets of light emissions produced by the light emitter, a second non-light-emission period of time T4 is longer than a first non-light-emission period of time T2. The controller estimates the biological information in a processing period of time T41 that is set in correspondence with the second non-light-emission period of time T4.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: August 24, 2021
    Assignees: ALPS ALPINE CO., LTD., Genial Light CO., LTD.
    Inventors: Yukio Otaki, Toshio Kawano, Naoki Ito, Ryo Shimokita
  • Patent number: 11076805
    Abstract: A wearable diagnostic device worn on a user's body that can provide various types of health-related information to the user is described. The wearable diagnostic device can provide real-time, non-invasive, accurate, and continuous data regarding a user's heart rate, hemoglobin level, body temperature, oxygen level, glucose level, and blood pressure. In some implementations, the wearable diagnostic device may also provide electrocardiogram (EKG) data or detection of Parkinson's symptoms, such as the involuntary movement of a user's hand. A user may configure the wearable diagnostic device to provide information on one, multiple, or all of the health-related information noted above.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: August 3, 2021
    Inventor: Saleem Sayani
  • Patent number: 11058333
    Abstract: A system includes an enclosure having a processor and a memory coupled to the processor. The enclosure includes a display coupled to the processor where the display is visible from an exterior of the enclosure; and a battery within the enclosure coupled to the processor and the display. The enclosure includes a probe tip coupled to an exterior of the enclosure. The probe tip includes first, second, and third sensor openings. A first distance between the first and second sensor openings is different than a second distance between the first and third sensor openings. The enclosure includes code stored in the memory where the code is executable by the processor, and includes code to receive first data associated with the first and second sensor openings, code to receive second data associated with the first and second sensor openings, and code to perform SRS using the first and the second data.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: July 13, 2021
    Assignee: ViOptix, Inc.
    Inventors: Kate LeeAnn Bechtel, Joseph Heanue, Lester John Lloyd, Edward Solomon
  • Patent number: 11051728
    Abstract: An apparatus comprising: a light detector; a light source, laterally offset from the light detector by a first lateral offset; optics configured to receive light emitted by the light source and output the received light, wherein a majority of the light output is directed towards an offset region laterally offset from the light detector by at least a second lateral offset different from the first lateral offset.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: July 6, 2021
    Assignee: NOKIA TECHNOLOGIES OY
    Inventors: Harri Lasarov, Antti Salo, Teemu Ahmaniemi
  • Patent number: 11033209
    Abstract: A system and method to measure blood oxygenation levels and total hemoglobin on individually selected blood vessels, to provide a representation of the subject condition and of tissue perfusion that may be used for diagnosing specific tissue conditions. Reflection spectra from individual blood vessels or a collection of vessels are measured by using wide-field imaging for selecting target vessels and a narrow-field confocal detection system to enable measuring local blood oxygenation and hemoglobin. Optical fibers may be used to illuminate the target vessel and to detect light diffusively reflected therefrom. The reflection spectra may be analyzed in a spectrometer to extract the ratio of the deoxy- to oxyhemoglobin and to determine their absolute concentration for computing total hemoglobin levels. An alternative implementation uses image processing on camera images of a blood vessel, generated at an isosbestic wavelength of the deoxy- and oxyhemoglobin, and optionally also at neighboring wavelengths.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: June 15, 2021
    Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
    Inventor: Dvir Yelin
  • Patent number: 11029189
    Abstract: A liquid surface detecting apparatus including: a retaining section that retains liquid as sample or reagent; a light emitter that emits light toward the liquid retained in the retaining section; an image capturing device that captures an image of the liquid retained in the retaining section; and a detecting device that detects a level of a liquid surface of the liquid retained in the retaining section based on the image of the liquid captured by the image capturing device, wherein the image capturing device is provided at a position such that the light, emitted by the light emitter and reflected by the liquid surface of the liquid, directly enters the image capturing device.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: June 8, 2021
    Assignees: SYSMEX CORPORATION, KAWASAKI JUKOGYO KABUSHIKI KAISHA
    Inventors: Yukio Iwasaki, Satoshi Ouchi, Eiji Mitsui, Junichi Matsuoka, Takehiro Hasegawa
  • Patent number: 10996173
    Abstract: Non-linear methods for quantitative elemental analysis and mineral classification using laser-induced breakdown spectroscopy are disclosed. According to one embodiment, a method, comprises calculating concentrations of elements in a sample using a laser-induced breakdown spectroscopy (LIBS) instrument. The LIBS instrument implements a kernel partial-least-squares regression (KPLSR) analysis. The method further comprises displaying the concentrations of the elements according to the KPLSR analysis.
    Type: Grant
    Filed: August 15, 2018
    Date of Patent: May 4, 2021
    Assignee: SETI INSTITUTE
    Inventor: Pablo Sobron
  • Patent number: 10987055
    Abstract: A substance concentration monitoring method includes inserting a temperature probe noninvasively into a volume of a body in which a concentration of a substance is to be measured. An internal temperature of the volume is measured and an internal temperature signal is produced. An incident first near infrared beam in a first wavelength band is directed from a light source into a portion of the volume, the first wavelength band including a wavelength at which an absorption peak exists in a NIR absorption spectrum of the substance. An incident second NIR beam in a second wavelength band is directed from the light source into the portion of the volume, the substance exhibiting no absorption or negligible absorption in the second wavelength band. Substance concentration is calculated based on values corresponding to the internal temperature signal, a first and second initial power signal, and a first and second material absorption signal.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: April 27, 2021
    Assignee: GlucoVista Inc.
    Inventor: Yonatan Gerlitz
  • Patent number: 10962524
    Abstract: An integrated system for determining a hemostasis and oxygen transport parameter of a blood sample, such as blood, is disclosed. The system includes a measurement system, such as an ultrasonic sensor, configured to determine data characterizing the blood sample. For example, the data could be displacement of the blood sample in response to ultrasonic pulses. An integrated aspect of the system may be a common sensor, sample portion or data for fast and efficient determination of both parameters. The parameters can also be used to correct or improve measured parameters. For example, physiological adjustments may be applied to the hemostatic parameters using a HCT measurement. Also, physical adjustments may be applied, such as through calibration using a speed or attenuation of the sound pulse through or by the blood sample. These parameters may be displayed on a GUI to guide treatment.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: March 30, 2021
    Assignee: HomoSonics LLC
    Inventors: Francesco Viola, William F. Walker
  • Patent number: 10957179
    Abstract: A method and system for communicating estimated blood loss parameters of a patient to a user, the method comprising: receiving data representative of an image, of a fluid receiver; automatically detecting a region within the image associated with a volume of fluid received at the fluid receiver, the volume of fluid including a blood component; calculating an estimated amount of the blood component present in the volume of fluid based upon a color parameter represented in the region, and determining a bias error associated with the estimated amount of the blood component; updating an analysis of an aggregate amount of the blood component and an aggregate bias error associated with blood loss of the patient, based upon the estimated amount of the blood component and the bias error; and providing information from the analysis of the aggregate amount of the blood component and the aggregate bias error, to the user.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: March 23, 2021
    Assignee: Gauss Surgical, Inc.
    Inventors: Siddarth Satish, Andrew T. Hosford, Kevin J. Miller, Milton McColl, Juan Carlos Aragon
  • Patent number: 10918320
    Abstract: A method for predicting a blood glucose level using a near-Infrared (NIR) spectrometer is provided. The method may include obtaining a feature set from an NIR glucose spectra; and predicting glucose values from the feature set based on a binary classification of the NIR glucose spectra and an in-class prediction of glucose using Machine Learning Regression.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: February 16, 2021
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Sujit Jos, Kiran Bynam, So Young Lee, Gorish Aggarwal, Srikanth Mallavarapu Rama
  • Patent number: 10905375
    Abstract: A monitor system configured to selectively attach a light emitter assembly and a light receiver assembly to a finger. The monitor system comprising the light emitter assembly, the light receiver assembly, an upper assembly a lower assembly, and an intermediate support. The monitor system comprises an attached portion and a detached portion. The attached portion is configured to attach to a fingernail of the finger. The detached portion is configured to selectively and releasably attach to the attached portion. The monitor system is configured to emit one or more emitted lights through the finger between the light emitter assembly and the light receiver assembly.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: February 2, 2021
    Inventor: Kenneth Ehrlich
  • Patent number: 10881336
    Abstract: A solution containing a target molecule and a reference molecule is illuminated to obtain Raman signals. An optical metasurface is used as a diffractive optical element to split the Raman signal from the target molecule and the Raman signal from the reference molecule. The target and reference Raman signals can be detected at different locations with different photodetectors, and the target molecule concentration in the solution is determined by comparing the target and reference Raman signals.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: January 5, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Andrei Faraon, Amir Arbabi, Yu Horie
  • Patent number: 10874348
    Abstract: The present disclosure generally relates to wearable devices and methods for measuring a photoplethysmographic signal. The wearable devices and methods may include a force sensor that provides input used for motion-noise filtering to obtain improved PPG signals. Feedback from the force sensor may also be used to indicate whether the amount of pressure exerted by the device should be adjusted, or whether the device should be switched to a locked state.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: December 29, 2020
    Assignee: Apple Inc.
    Inventors: Chin San Han, Vivek Venugopal, Ueyn L. Block, Nicholas Paul Joseph Allec
  • Patent number: 10863937
    Abstract: A method for calibration of a photoplethysmographic device including the steps of providing a fluid circuit (305) for blood or other liquid, a pump mechanism (310) to generate pulsatile flow of blood through the fluid circuit, a sample of excised tissue (315) in the fluid circuit through which the blood flows, and a photoplethysmographic device including an emitter and a photodetector (330) positioned on the tissue (335, 340) so that a portion of the light output by the emitter passes through the tissue and is incident on the photodetector. The method further includes the steps of energizing the pump mechanism (420) to move the blood through the tissue, energizing the emitter (425) to output light, collecting paired data from the photodetector and from one or more reference measurements (430), and processing the paired data to calibrate the photoplethysmographic device (435).
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: December 15, 2020
    Assignee: Kestrel Labs, Inc
    Inventor: Jonas Alexander Pologe
  • Patent number: 10849508
    Abstract: The present invention describes a system and method for continuous monitoring of central (aortic) and peripheral Blood Pressure. The system includes a fully mobile, non-invasive, continuous blood pressure monitoring system that includes one or more Biostrip devices affixed on a user, coupled with an application running on a computing device, which is further connected to a web server in the cloud. The system performs various computations on the Biostrip device, or on the gateway device (Smartphone or Smartwatch), or on the Cloud, and provides the user and authorized third parties with various insights about the blood pressure levels of the user. Further, the system enables the user to receive biofeedback training for controlling hypertension, and schedule online appointments, pay online for such appointments, share data the data securely to obtain insights.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: December 1, 2020
    Assignee: Fourth Frontier Technologies Pvt. Ltd.
    Inventors: Manav Bhushan, Sandeep Sibal
  • Patent number: 10791982
    Abstract: A computer based method and system forms measurements of brain function and predictions of a likelihood for memory impairment via the use of cameras, including a near-infrared (NIR) spectroscopic device and a camera capturing images in the Red-Green-Blue (RGB) spectrum. The device acquires from a subject measurements of ions, molecules, or combinations thereof at more than one moment in time, as well as amplitude and timing of blood pulsations. Based on the measured molecule or ion concentration, flow, and so forth, a processor assesses the probability of a neuron to form an action potential. Formation of an action potential increases the probability that the subject individual will create a memory.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: October 6, 2020
    Inventor: Stephanie Littell
  • Patent number: 10794942
    Abstract: A spectrum processing apparatus includes: a spectrum obtainer configured to obtain an optical spectrum from a light that is scattered or reflected from a subject; and a processor configured to split the optical spectrum into a plurality of bands, determine, based on a predetermined measurement accuracy for measuring a biosignal from the light, one or more key bands from the plurality of bands, and obtain the biosignal from the determined key bands.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: October 6, 2020
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Yun S Park, Sung Mo Ahn
  • Patent number: 10791255
    Abstract: A scanning optical system is provided including a source of optical radiation; an optical scanning beam delivery system for delivering optical radiation to a subject, wherein the optical scanning beam delivery system includes a plurality of optical elements including at least one steerable mirror; at least one actuator coupled to the at least one steerable mirror; a detection system for detecting optical radiation returned from a subject; a communications device including a user interface and configured to process a set of instructions at least partially responsive to inputs from the user interface; a controller comprising memory, a microcontroller and an field programmable gate array (FPGA), the microcontroller and FPGA receiving instructions derived from the communications device; and at least one actuator coupled to the at least one steerable mirror.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: September 29, 2020
    Assignee: Leica Microsystems Inc.
    Inventors: Mehran Ghofrani, Al-Hafeez Z. Dhalla, Christopher Saxer
  • Patent number: 10772542
    Abstract: A method and an apparatus for separating a composite signal into a plurality of signals is described. A signal processor receives a composite signal and separates a composite signal into separate output signals. Feedback from one or more of the output signals is provided to a configuration module that configures the signal processor to improve a quality of the output signals. In one embodiment, calibration data from multiple calibration data sets is used to configure the demodulation of the composite signal into separate output signals.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: September 15, 2020
    Assignee: Masimo Corporation
    Inventors: Walter M. Weber, Ammar Al-Ali, Mohamed K. Diab, Marcelo M. Lamego
  • Patent number: 10768165
    Abstract: An imaging system for measuring water and blood lipid content in a tissue sample includes a light source configured to emit a plurality of sequential wavelengths of light within a predetermined range of wavelengths, a spatial modulation device configured to direct each of the plurality of sequential wavelengths of light onto a tissue sample plane to generate a first plurality of patterns on the issue sample plane at a first spatial frequency and a second plurality of patterns on the tissue sample plane at a second spatial frequency, an imaging device configured to generate first image data reproducible as images the first plurality of patterns and second image data reproducible as images the second plurality of patterns, and a controller configured to determine a first optical property and a second optical property for each location on the sample plane.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: September 8, 2020
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Darren Roblyer, Yanyu Zhao
  • Patent number: 10751433
    Abstract: A method and system for treating a biological fluid within a container by subjecting the container to light is provided. The system includes a fluid treatment chamber for receiving the container of biological fluid; an agitation assembly for oscillating the container of biological fluid within the fluid treatment chamber including a variable speed motor; one or more light sources in proximity to the fluid treatment chamber; at least one sensor for sensing a condition of the biological fluid in the container; and a programmable controller.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: August 25, 2020
    Assignee: Fenwal, Inc.
    Inventors: Brett T. Crawley, Kyungyoon Min
  • Patent number: 10753862
    Abstract: In a method and apparatus, a property of an optically diffuse medium including a first optical absorber having a first concentration and a second optical absorber having a second concentration is determined. A surface area of the medium is imaged at multiple wavelengths around an isosbestic wavelength of the first absorber and the second absorber. A reflectance spectrum of the medium at the surface area at the multiple wavelengths is determined. A derivative of the determined reflectance spectrum around the isosbestic wavelength is determined. From the derivative, a concentration ratio of the first concentration and the second concentration is estimated.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: August 25, 2020
    Assignee: Stichting Het Nederlands Kanker Instituut-Antoni Van Leeuwenhoek Ziekenhuis
    Inventors: Theodoor Jacques Marie Ruers, Esther Kho, Henricus Josephus Cornelus Maria Sterenborg
  • Patent number: 10743802
    Abstract: A biological signal acquirer is attached to a subject and acquires a biological signal of the subject. A transmitter carried by the subject transmits the biological signal. A first communication port and a first camera are installed in a first location and connectable to a network. A second communication port and a second camera are installed in a second location and connectable to the network. A biological information acquiring device is connectable to the network and provided with a switcher. The switcher acquires, when communication establishment between the transmitter and the first communication port is detected, the biological signal through the first communication port as well as a first image taken by the first camera, and acquires, when communication establishment between the transmitter and the second communication port is detected, the biological signal through the second communication port as well as a second image taken by the second camera.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: August 18, 2020
    Assignee: NIHON KOHDEN CORPORATION
    Inventor: Nobuyoshi Watanabe
  • Patent number: 10705139
    Abstract: A semiconductor device inspection system (1) includes a laser beam source (2), for emitting light, an optical sensor (12) for detecting the light reflected by the semiconductor device (10) from the light and outputting a detection signal, a frequency band setting unit (16) for setting a measurement frequency band and a reference frequency band with respect to the detection signal, a spectrum analyzer (15) for generating a measurement signal and a reference signal from the detection signals in the measurement frequency band and the reference frequency band, and a signal acquisition unit (17) for calculating a difference between the measurement signal and the reference signal to acquire an analysis signal. The frequency band setting unit (16) sets the reference frequency band to a frequency domain in which a level of the detection signal is lower than a level obtained by adding 3 decibels to a white noise level serving as a reference.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: July 7, 2020
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventor: Tomonori Nakamura
  • Patent number: 10702173
    Abstract: A system and method for camera-based heart rate tracking. The method includes: determining bit values from a set of bitplanes in a captured image sequence that represent the HC changes; determining a facial blood flow data signal for each of a plurality of predetermined regions of interest (ROIs) of the subject captured by the images based on the HC changes; applying a band-pass filter of a passband approximating the heart rate to each of the blood flow data signals; applying a Hilbert transform to each of the blood flow data signals; adjusting the blood flow data signals from revolving phase-angles into linear phase segments; determining an instantaneous heart rate for each the blood flow data signals; applying a weighting to each of the instantaneous heart rates; and averaging the weighted instantaneous heart rates.
    Type: Grant
    Filed: July 9, 2019
    Date of Patent: July 7, 2020
    Assignee: NuraLogix Corporation
    Inventors: Kang Lee, Evgueni Kabakov, Phil Levy
  • Patent number: 10695005
    Abstract: The present invention discloses a non-invasive blood glucose measurement method, applied to noninvasive blood glucose measuring instruments including measuring hosts and fingertip measuring probes, comprising pre-storing a random forest algorithm and a neural network prediction algorithm in the measuring host; measuring energy metabolism parameters of a fingertip of an individual to be measured and transmitting the parameters to the measuring host by the fingertip measuring probe; calling the random forest algorithm to predict the blood glucose type of the energy metabolism parameters of the fingertip of the individual to be measured and calling the corresponding neural network prediction algorithm to calculate the blood glucose value of the fingertip of the individual to be measured by the measuring host. The present invention also provides a fingertip-measuring probe.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: June 30, 2020
    Assignees: Guilin Medicine Electronic Technology Co., Ltd., Guilin University of Electronic Technology
    Inventors: Zhencheng Chen, Jianming Zhu, Yongbo Liang, Shimin Yin, Guocheng Han, Biao Xu, Yang Zhang
  • Patent number: 10691072
    Abstract: A wearable device can include an electronic device and a band for securing the electronic device to the user. The electronic device can detect an identification of the band, which can serve as an input to initiate actions performed by the electronic device. For example, a type, model, color, size, or other characteristic of a band can be determined and used to select a corresponding action performed by the electronic device. Identification of the band can be performed by components of the electronic device that also serve other purposes. Existing sensors, communication elements, and/or detectors can be used to detect and identity a band provided to the electronic device. The electronic device can respond to the identification of a particular band by performing particular functions, such as changing an aspect of a user interface or altering settings of the electronic device.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: June 23, 2020
    Assignee: Apple Inc.
    Inventor: Timothy M. Johnson
  • Patent number: 10674962
    Abstract: A finger clamping device and an oximeter using the finger clamping device are provided. The finger clamping device includes a shell, an upper clamping member, and a lower clamping member. The shell includes two oppositely facing sidewalls. Each sidewall defines at least one sliding rail. The upper clamping member is arranged in the shell and defines two guiding rods. The two guiding rods are received in and slide along the sliding rail. At least one elastic member joins the lower clamping member and the upper clamping member and is tensioned when a finger is inserted between the upper clamping member and the lower clamping member.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: June 9, 2020
    Assignee: Hangzhou Jiangyu Innovation Medical Technology CO., LTD
    Inventors: Zhan-Sheng Lu, Yu-Chun Sun
  • Patent number: 10660551
    Abstract: A concentration measurement apparatus measures a temporal relative change amount (?cHb, ?O2Hb) of either or both of total hemoglobin concentration and oxygenated hemoglobin concentration in the head that vary due to repetition of chest compression, and includes a light incidence section making measurement light incident on the head, a light detection section detecting the measurement light propagated through the interior of the head and generating a detection signal in accordance with the intensity of the measurement light, and a CPU determining, based on the detection signal, the relative change amount (?cHb, ?O2Hb) and performing a filtering process of removing frequency components less than a predetermined frequency from frequency components contained in the relative change amount (?cHb, ?O2Hb).
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: May 26, 2020
    Assignees: ST. MARIANNA UNIVERSITY SCHOOL OF MEDICINE, HAMAMATSU PHOTONICS K.K.
    Inventors: Yasuaki Koyama, Takeo Ozaki, Susumu Suzuki
  • Patent number: 10649308
    Abstract: A coherent photon analog-to-digital conversion device comprising an optical clock oscillation source, a sampled signal source, a photon sampling gate, a photoelectric detection module, an electrical sampling module, a phase detection module, a loop filter, and signal feedback links. By adjusting the optical clock oscillating source or the sampled signal source, the invention makes the two highly coherent, thereby reducing the clock jitter and greatly improving the sampling precision. It is very important for improving the performance of microwave photon systems that require high time accuracy and high sampling accuracy, such as microwave photon radar and optical communication systems.
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: May 12, 2020
    Assignee: Shanghai Jiao Tong Technology
    Inventors: Weiwen Zou, Guang Yang, Lei Yu, Na Qian, Jianping Chen
  • Patent number: 10635926
    Abstract: An image analyzing apparatus reprojects an input image in a plurality of different directions to divide the input image into a plurality of partial images, extracts a feature amount from each of the partial images, and calculates a degree of importance of the input image by position from the extracted feature amount in accordance with a predetermined regression model.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: April 28, 2020
    Assignee: RICOH COMPANY, LTD.
    Inventor: Takayuki Hara
  • Patent number: 10524735
    Abstract: This relates to methods for measuring irregularities in a signal and corresponding devices. The devices can include a PPG sensor unit configured to detect multiple occurrences of a given event in the measured signal(s) over a sampling interval. In some instances, the device can register the occurrences of the events. In some examples, the device can include one or more motion sensors configured to detect whether the device is in a low-motion state. The device may delay initiating measurements when the device is not in a low-motion state to enhance measurement accuracy. Examples of the disclosure further include resetting the sample procedure based on one or more factors such as the number of non-qualifying measurements. In some examples, the device can be configured to perform both primary and secondary measurements, where the primary measurements can include readings using a set of operating conditions different from the secondary measurements.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: January 7, 2020
    Assignee: Apple Inc.
    Inventors: Stephen J. Waydo, Christopher J. Brouse, Ian R. Shapiro, Joseph C. McBride, Michael O'Reilly, Myra Mary Haggerty
  • Patent number: 10463283
    Abstract: An exemplary system comprises an energy transmitter, an energy receiver, and an analyzer. The energy transmitter may project energy at a first wavelength and a second wavelength into tissue of a user, the first wavelength and the second wavelength being associated with at least one nutrient of a set of nutrients in blood of the user. The energy receiver may generate a composite signal based on a fraction of the energy at the first wavelength and the second wavelength, the fraction of the energy being received through the tissue of the user. The analyzer may separate the composite signal into a first signal corresponding to the first wavelength and a second signal corresponding to the second wavelength, and detect, in the blood of the user, a concentration of the at least one nutrient of the set of nutrients based on the first signal and the second signal.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: November 5, 2019
    Assignee: Spry Health, Inc.
    Inventors: Elad Ferber, Pierre-Jean Cobut
  • Patent number: 10441203
    Abstract: A space-saving structural component for a device, the device configured to non-invasively determine a tissue bioparameter of a mammalian subject, the component comprising a wall surface including a grooved recess and at least one shoulder; and a substantially flat cover, the cover configured to cover the wall surface by moving from an open position far enough away from the wall surface to allow insertion of an appendage of the subject into a chamber defined by the grooved recess and the cover, to a closed position, the cover comprising a flexible material that, in the closed position, elastically deforms away from the wall surface when the appendage is present in the grooved recess and restores to a substantially flat state when the appendage is absent from the grooved recess, wherein in the closed position, when the appendage is absent from the recess, the cover is adjacent the at least one shoulder.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: October 15, 2019
    Assignee: CNOGA MEDICAL LTD.
    Inventor: Yosef Segman
  • Patent number: 10426356
    Abstract: A method and system for communicating estimated blood loss parameters of a patient to a user, the method comprising: receiving data representative of an image, of a fluid receiver; automatically detecting a region within the image associated with a volume of fluid received at the fluid receiver, the volume of fluid including a blood component; calculating an estimated amount of the blood component present in the volume of fluid based upon a color parameter represented in the region, and determining a bias error associated with the estimated amount of the blood component; updating an analysis of an aggregate amount of the blood component and an aggregate bias error associated with blood loss of the patient, based upon the estimated amount of the blood component and the bias error; and providing information from the analysis of the aggregate amount of the blood component and the aggregate bias error, to the user.
    Type: Grant
    Filed: January 3, 2018
    Date of Patent: October 1, 2019
    Assignee: Gauss Surgical, Inc.
    Inventors: Siddarth Satish, Andrew T. Hosford, Kevin J. Miller, Milton McColl, Juan Carlos Aragon
  • Patent number: 10416094
    Abstract: A system for characterizing a dielectric object situated adjacent to an electrically conductive surface comprises a radiation source configured to radiate electromagnetic energy toward the dielectric object, and a receiver configured to receive scattered electromagnetic energy scattered by the dielectric object and the electrically conductive surface. The system may further comprise a control subsystem, coupled to the radiation source and the receiver, that determines an apparent focal point within the object, determines a phase shift associated with the scattered electromagnetic energy with respect to the electromagnetic energy radiated by the radiation source, and determine a thickness and an index of refraction of the object based, on the apparent focal point and the phase shift. The system may determine the apparent focal point by scanning a calculated focus point of the radiated energy through different depths of the object, and searching for a peak in an amplitude of the scattered energy.
    Type: Grant
    Filed: March 17, 2017
    Date of Patent: September 17, 2019
    Assignee: Northeastern University
    Inventors: Carey Rappaport, Jose A. Martinez-Lorenzo, Ann Morgenthaler
  • Patent number: 10352922
    Abstract: A system for measuring hematocrit in a whole blood sample is provided. An absorbent substrate is adapted to receive a whole blood sample. At least one light source is positioned to illuminate the sample on the substrate at first and second wavelengths. The first and second wavelengths are different from each other. A spectral sensor is positioned to measure a first intensity and a second intensity of light diffusely reflected from the sample at the first and second wavelengths, respectively. The diffusely reflected first and second intensities of light are compared to reference values to generate first and second reflectance values. A controller, coupled to the spectral sensor, is configured to determine a first differential reflectance between the first and second reflectances. The hematocrit level of the sample is determined based on a first stored relationship between hematocrit and a differential reflectance corresponding to the first and second wavelengths.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: July 16, 2019
    Assignee: THERMO FINNIGAN LLC
    Inventors: Steven L. Reeber, John Glazier
  • Patent number: 10321115
    Abstract: A three-dimensional (3D) depth sensor may include: a plurality of light sources configured to irradiate light to an object, the light having different center wavelengths; an optical shutter configured to allow reflected light reflected from the object to pass through; and an image sensor configured to filter the reflected light having passed through the optical shutter and detect the filtered light.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: June 11, 2019
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Weiming Li, Mingcai Zhou, Ya Lu, Chun Wang, Myungjae Jeon
  • Patent number: 10299724
    Abstract: A wristwatch includes a case containing electronic components of the wristwatch. An optoelectronic module including at least one light emitting element and at least one light sensing element is disposed within the case or within a fastener for the wristwatch. The optoelectronic module is operable to obtain physiological data of a person wearing the wristwatch by using the light emitting element and the light sensing element.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: May 28, 2019
    Assignee: ams Sensors Singapore Pte. Ltd.
    Inventor: Ohad Meitav
  • Patent number: 10282839
    Abstract: A variation of a method for estimating a quantity of a blood component in a fluid canister includes: within an image of a canister, identifying a reference marker on the canister; selecting an area of the image based on the reference marking; correlating a portion of the selected area with a fluid level within the canister; estimating a volume of fluid within the canister based on the fluid level; extracting a feature from the selected area; correlating the extracted featured with a concentration of a blood component within the canister; and estimating a quantity of the blood component within the canister based on the estimated volume and the concentration of the blood component within the canister.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: May 7, 2019
    Assignee: Gauss Surgical, Inc.
    Inventors: Siddarth Satish, Ali Zandifar, Kevin J. Miller
  • Patent number: 10258265
    Abstract: The present disclosure relates to noninvasive methods, devices, and systems for measuring various blood constituents or analytes, such as glucose. In an embodiment, a light source comprises LEDs and super-luminescent LEDs. The light source emits light at least wavelengths of about 1610 nm, about 1640 nm, and about 1665 nm. In an embodiment, the detector comprises a plurality of photodetectors arranged in a special geometry comprising one of a substantially linear substantially equal spaced geometry, a substantially linear substantially non-equal spaced geometry, and a substantially grid geometry.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: April 16, 2019
    Assignee: MASIMO CORPORATION
    Inventors: Jeroen Poeze, Marcelo Lamego, Sean Merritt, Cristiano Dalvi, Hung Vo, Johannes Bruinsma, Ferdyan Lesmana, Massi Joe E. Kiani, Greg Olsen
  • Patent number: 10247666
    Abstract: A detector has a sensor responsive to a first wavelength, a sensor responsive to a second wavelength, and a sensor for collecting reference readings. A gas sample is analyzed to obtain readings corresponding to the first wavelength, the second wavelength and a reference. A first absorption figure is calculated using the first reading and the reference reading, and a second absorption figure using the second reading and the reference reading. A linearizer function is applied to the first and second absorption figures to calculate first and second concentration figures. The sensor for each wavelength is calibrated for detecting the first gas such that the data collected at each wavelength gives the same reading when only the first gas is present. The ratio of the first concentration figure to the second concentration figure is used to identify whether only the first gas is present.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: April 2, 2019
    Assignee: Gas Measurement Instruments Limited
    Inventors: Crawford Massie, Fraser Mathieson, Andrew Glendinning
  • Patent number: 10241034
    Abstract: A concentration measurement method accurately, quickly, and non-destructively measures the concentration of a predetermined chemical component within an object to a nano-order trace concentration level in real time. A time sharing method irradiates the object light of a first wavelength and light of a second wavelength having different light absorption rates with respect to the object to be measured. Light of both wavelengths that arrives optically through the object is received by a shared light reception sensor, and signals respectively relating to light of the first and second wavelengths are output from the light reception sensor in accordance with the received light. A differential signal of these signals is formed, and the concentration of a chemical component in the object to be measured is derived on the basis of the differential signal.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: March 26, 2019
    Assignee: TOHOKU UNIVERSITY
    Inventors: Shigetoshi Sugawa, Rihito Kuroda
  • Patent number: 10231670
    Abstract: Systems and methods are disclosed for proximity sensing in physiological sensors, and more specifically to using one or more proximity sensors located on or within a physiological sensor to determine the positioning of the physiological sensor on a patient measurement site. Accurate placement of a physiological sensor on the patient measurement site is a key factor in obtaining reliable measurement of physiological parameters of the patient. Proper alignment between a measurement site and a sensor optical assembly provides more accurate physiological measurement data. This alignment can be determined based on data from a proximity sensor or sensors placed on or within the physiological sensor.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: March 19, 2019
    Assignee: MASIMO CORPORATION
    Inventors: Thomas B. Blank, Gregory A. Olsen, Cristiano Dalvi, Hung T. Vo
  • Patent number: 10219746
    Abstract: An embodiment of the present disclosure seeks to select characteristics of incoming intensity data that cause comparisons of selected characteristics to produce defined probe off space having reduced crossover with defined probe on space. Once defined, the present disclosure compares characteristics of incoming intensity data with the now defined probe off space, and in some embodiments, defined probe on space, to determine whether a probe off condition exists. When a processor determines a probe off condition exists, the processor may output or trigger an output signal that audibly and/or visually indicates to a user that the optical sensor should be adjusted for a proper application to a measurement site.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: March 5, 2019
    Assignee: Masimo Corporation
    Inventors: Ryan Timothy McHale, Walter M. Weber
  • Patent number: 10132792
    Abstract: Disclosed herein are portable diagnostic measurement devices for determining at least one analysis parameter of a bodily fluid, in particular for determining an analyte concentration in a bodily fluid as can occur in blood glucose determinations. Also disclosed are analysis systems including the measurement device and at least one disposable test element. The test element can be designed as a carrier strip and can contact a receiving surface of the measurement device at least partially in a flat manner, where the receiving surface is arranged on a narrow side of the housing of the measurement device.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: November 20, 2018
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Heino Eikmeier, Hans-Peter Haar, Joachim Hoenes, Carina Horn, Ewald Rieger
  • Patent number: 10085679
    Abstract: A system and method for detecting vascular contamination by surgical anesthetic using non-invasive IR spectrophotometry. One embodiment is a method for operating an instrument such as an enhanced pulse oximeter to monitor a patient receiving local anesthetic marked with dye that absorbs infrared light. Light is applied to and detected from tissue of the patient. A signal representative of the detected light is processed to derive patient oxygenation information. The detected light is also processed to derive information representative of the presence of the dye-marked anesthetic. The oxygenation information and the information representative of the presence of anesthetic are displayed. The oxygenation monitoring and display and the anesthetic monitoring and display can occur separately or concurrently. Fluorescing dyes and fluorescence detection approaches are used for anesthetic detection in some embodiments.
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: October 2, 2018
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Steven R. Clendenen, Clifton R. Haider, Barry K. Gilbert, Oliver William Spees
  • Patent number: 10048114
    Abstract: In a device for measuring the vibrational amplitude of a capillary tube of a wire bonder, the capillary tube is placed between a light source and a detector system, so that the vibrational amplitude is able to be ascertained from the shading of a beam of light by the capillary tube. The beam of light emitted by the light source is split into a measuring beam of light and a reference beam of light, an edge of the capillary tube at least partially shading the measuring beam of light in the vibrating state, while the reference beam of light is not shaded. The detector system includes a measuring detector assigned to the measuring beam of light as well as at least one reference detector assigned to the reference beam of light, and the vibrational amplitude of the capillary tube is ascertainable from the interconnected output signals of the measuring detector and the reference detector.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: August 14, 2018
    Assignee: DR. JOHANNES HEIDENHAIN GMBH
    Inventors: Walter Huber, Wolfgang Holzapfel
  • Patent number: 10039491
    Abstract: Optical measurement of physiological parameters with wearable devices often includes measuring signals in the presence of significant noise sources. These noise sources include, but are not limited to, noise associated with: variable optical coupling to skin or tissue, variations in tissue optical properties with time due to changes in humidity, temperature, hydration, variations in tissue optical properties between individuals, variable coupling of ambient light sources into detectors, and instrument and detector noise, including electrical noise, radio frequency or magnetic interference, or noise caused by mechanical movement of the detector or its components. The present disclosure includes devices and methods configured to produce representations of the raw data in which noise, broadly defined, is separated from the data of interest. The disclosed devices and methods may include subtracting or calibrating out these noise sources and other spurious fluctuations in wearable devices with optical sensors.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: August 7, 2018
    Assignee: Verily Life Sciences LLC
    Inventors: Jason Donald Thompson, Vikram Singh Bajaj, Victor Marcel Acosta, Tamara Lynn Troy