Determining Blood Constituent Patents (Class 600/322)
  • Patent number: 11445906
    Abstract: A system includes a monitor configured to be coupled to multiple sensors over time to monitor one or more physiological characteristics of one or more patients, and including an information collection system configured to store in a database unique sensor identifying information and information related to plural uses of the same sensor.
    Type: Grant
    Filed: July 27, 2020
    Date of Patent: September 20, 2022
    Assignee: COVIDIEN LP
    Inventors: Daniel Lisogurski, Rakesh Sethi
  • Patent number: 11426196
    Abstract: An illuminated needle device for performing a heart valve repair includes an outer member and an inner member. The outer member includes a body that has a proximal end and a distal end. The body of the outer member defines a lumen therethrough and the distal end of the body includes a needle. The inner member is slidably disposed within the lumen of the outer member. The inner member includes a distal end that has a radiation emitting element. The illuminated needle device is characterized by the outer and inner members together forming a flexible, elongate shaft, and the inner member being configured to emit radiation from the radiation emitting element from a location proximate to the distal end of the outer member.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: August 30, 2022
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: James P. Rohl, Craig M. Wilson, Benn Horrisberger, Carl W. Bauer, Lance A. Freeseman
  • Patent number: 11419511
    Abstract: The invention provides a physiological parameter sensing system (50) and method in which physiological information indicative of at least one physiological parameter is derived. The approach of the invention is based on constructing multiple pulse signals from different weighted combinations of at least two detection signals, derived from detected electromagnetic radiation directed onto or through a subjects skin region. The weightings are based on different of a set of various blood volume pulse vectors. A quality indication value is derived for each generated pulse signal, where this is based on a derived relationship between an obtained heart rate signal for the patient and the pulse signal. The blood volume pulse vector resulting in the pulse signal having the highest quality indicator value and/or from the derived pulse signal itself is used to derive the physiological parameter information.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: August 23, 2022
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Laurentia Johanna Huijbregts, Gerard De Haan, Mark Josephus Henricus Van Gastel
  • Patent number: 11412988
    Abstract: A monitoring device configured to be attached to a subject includes a photoplethysmography (PPG) sensor configured to detect/measure physiological information from the subject, and a processor configured to process the physiological information to detect subject stress, and to determine an origin of the subject stress. The processor can determine the origin of the subject stress by increasing a sampling rate of the PPG sensor to collect higher acuity physiological information. The processor also can determine the origin of the subject stress by processing data from the PPG sensor to determine whether the subject is likely to have atrial fibrillation. In response to determining that the subject is likely to have atrial fibrillation, the processor can increase a frequency of pulsing of an optical emitter of the PPG sensor and/or increase a sampling rate of the PPG sensor to collect higher acuity data for diagnosing that atrial fibrillation is truly occurring.
    Type: Grant
    Filed: July 19, 2019
    Date of Patent: August 16, 2022
    Assignee: Valencell, Inc.
    Inventors: Steven Francis LeBoeuf, Jesse Berkley Tucker, Michael Edward Aumer, Steven Matthew Just, Mark Andrew Felice
  • Patent number: 11399749
    Abstract: Provided is an optical sensor, including a light source configured to emit light; a photodetector array comprising a plurality of photodetectors positioned at different distances from the light source, each photodetector being configured to detect an optical signal returning from an object irradiated by the light emitted by the light source, and to measure a light intensity of the detected optical signal; and a processor configured to determine a correlation coefficient between variables based on the measured light intensity, and to determine a quality of the optical signal based on the determined correlation coefficient, an optical characteristic of the object being determined by selectively using the optical signal of which the quality is an acceptable level or higher.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: August 2, 2022
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Joon Hyung Lee, Kak Namkoong, Jung Yong Nam, Yeol Ho Lee, Ki Young Chang, Won Jong Jung
  • Patent number: 11399746
    Abstract: A personalized bio-information correcting apparatus includes a communication interface configured to acquire original bio-information value data of a user, and a processor configured to obtain a personalized bio-information guideline, based on a personalized physiological model, identify whether at least one value among the acquired original bio-information value data is an outlier, based on the obtained personalized bio-information guideline, and based on the at least one value among the acquired original bio-information value data being identified to be the outlier, obtain final bio-information value data by correcting the at least one value among the acquired original bio-information value data.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: August 2, 2022
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Ka Ram Choi, So Young Lee
  • Patent number: 11363973
    Abstract: A personal hand-held monitor (PHHM) comprising a signal acquisition device for acquiring signals which can be used to derive a measurement of a parameter related to the health of the user, wherein the signal acquisition device comprises a blood photosensor having one or more photo-emitters for transmitting light to a body part of a user, one or more photo-detectors for detecting light transmitted through or scattered by the body part and two or more optical cells, at least one of which contains an analyte to be detected or which mimics the absorption spectrum of the analyte to be detected, through which the light that has been or will be transmitted through or scattered by the body part passes before it reaches the or each photo-detector, wherein the processor of the PHHM is adapted to process the signals received from the or each photo-detector to calculate the difference in intensity of light which has passed through the or each analyte cell and light which has passed through the or each non-analyte cell an
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: June 21, 2022
    Assignee: LEMAN MICRO DEVICES SA
    Inventors: Christopher Elliott, Mark-Eric Jones
  • Patent number: 11350821
    Abstract: An ambulatory medical device and a method of communication between medical devices are disclosed. In one embodiment, the medical device includes a module for communication with at least a second medical device wherein the module for communication is adapted to be activated by a value of a physiological parameter of an animal. In one embodiment, the method of the present invention involves a first medical device and at least a second medical device wherein the communication between said medical devices is activated by a value of a physiological parameter of an animal.
    Type: Grant
    Filed: August 1, 2007
    Date of Patent: June 7, 2022
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Matthias Essenpreis, Ulrich Haueter, Nicole Bernini, Sybille Fankhauser, Sebastiaan La Bastide, Gunnar Meyer Olden, Michael Schoemaker, Kelly Heaton, Joel Jeckelmann
  • Patent number: 11351555
    Abstract: A holder (40) for holding a stack (10) of coverslips (11) or specimen slides (11) has a bottom (20) having at least one side wall (21a, 21b, 22a, 22b) connected thereto, wherein an inner side of the bottom (20) is embodied for placement of the stack (10) of coverslips (11) or specimen slides (11) and carrying that stack (10), and an outer side of the bottom (20) and/or an outer side of the at least one side wall is configured to receive an identification label, such as an RFID (30), and the holder includes such the identification label, such as an RFID (30).
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: June 7, 2022
    Assignee: Leica Biosystems Nussloch GmbH
    Inventor: Tobias Trump
  • Patent number: 11344203
    Abstract: A system is provided for scanning organs in a human body, preferably a human's cardiovascular system more preferably the heart and other arteries. The system includes an extracorporeal opto-acoustic scanning device for scanning from outside of the body and optionally in correlation to inside optic imaging Both comprise a laser or other opto acoustic light and a transducer. The laser being arranged to emit laser pulses towards and/or into the organ system and the transducer being arranged to detect acoustic waves received back from the organ system for imaging the scanned tissue.
    Type: Grant
    Filed: September 15, 2018
    Date of Patent: May 31, 2022
    Assignee: PRC CARDIO OPTIC LTD.
    Inventor: Arie Huber
  • Patent number: 11337655
    Abstract: A monitoring device configured to be attached to a subject includes a photoplethysmography (PPG) sensor configured to measure physiological information from the subject, and at least one processor configured to process signals from the PPG sensor to determine heart rate and RR-interval (RRi) for the subject, and to determine a heart rate pattern for the subject over a period of time. The at least one processor is configured to change a sampling frequency of the PPG sensor for determining RRi in response to the determined heart rate pattern. The at least one processor is configured to reduce the sampling frequency of the PPG sensor in response to determining a pattern of heart rate below a threshold.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: May 24, 2022
    Assignee: Valencell, Inc.
    Inventors: Steven Francis LeBoeuf, Jesse Berkley Tucker, Michael Edward Aumer, Steven Matthew Just, Mark Andrew Felice
  • Patent number: 11324445
    Abstract: A headset includes a housing defining an audio cavity, a speaker located within the audio cavity, and first and second sensor modules within the housing in spaced-apart, angled relationship to each other. The housing includes an aperture through which sound from the speaker can pass, and the first and second sensor modules are on opposing sides of a direction from the speaker to the aperture. The first sensor module is configured to direct electromagnetic radiation at a first target region of an ear of a person wearing the headset and to detect a first energy response signal therefrom that is associated with one or more physiological metrics of the subject, and the second sensor module is configured to direct electromagnetic radiation at a second target region of the ear and to detect a second energy response signal therefrom that is associated with the one or more physiological metrics.
    Type: Grant
    Filed: October 24, 2018
    Date of Patent: May 10, 2022
    Assignee: Valencell, Inc.
    Inventors: Steven Francis LeBoeuf, Jesse Berkley Tucker, Michael Edward Aumer, Eric Douglas Romesburg, Joseph Norman Morris
  • Patent number: 11272849
    Abstract: An apparatus adapted to be worn at or near at least one ear of a subject includes a battery, a reflective pulse oximeter, a motion sensor, an analog-to-digital convertor configured to convert analog signals from the reflective pulse oximeter and the motion sensor into digitized information, a speaker, a digital memory device configured to store at least one algorithm for signal processing, a transceiver, and a signal processor. The signal processor is configured to process data from the reflective pulse oximeter to monitor cardiopulmonary functioning of the subject, process data from the motion sensor to monitor head and body motion, execute the at least one algorithm for assessing a health state of a subject, poll the reflective pulse oximeter and the motion sensor at certain time intervals to extend life of the battery, and process digital audio information into analog sounds to be presented to the subject via the speaker.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: March 15, 2022
    Assignee: Valencell, Inc.
    Inventors: Steven Francis LeBoeuf, Jesse Berkley Tucker, Michael Edward Aumer
  • Patent number: 11246517
    Abstract: A spectrophotometric apparatus for determining optical parameters in a scattering medium based on the measurement of attenuation of light propagating through said medium by diffusion. To eliminate the detrimental effect of light being guided in an intermediate optical layer between a surface of the medium and a contact surface of the apparatus, either a multitude of optical barriers may be formed in the contact surface or the angular range over which light is emitted or received by the apparatus may be limited by appropriate means. With both of these alternative approaches, light propagation in the intermediate layer can be suppressed, leading to increased measurement accuracy. This is particularly beneficial for building an oximeter with improved precision. Further aspects include features for improving the applicability of the apparatus on curved surfaces such as the strongly curved skulls of neonates.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: February 15, 2022
    Assignee: Universit├Ąt Z├╝rich
    Inventors: Stefan Kleiser, Martin Wolf, Daniel Ostojic, Nassimsadat Nasseri
  • Patent number: 11224381
    Abstract: An embodiment of the present disclosure seeks to select characteristics of incoming intensity data that cause comparisons of selected characteristics to produce defined probe off space having reduced crossover with defined probe on space. Once defined, the present disclosure compares characteristics of incoming intensity data with the now defined probe off space, and in some embodiments, defined probe on space, to determine whether a probe off condition exists. When a processor determines a probe off condition exists, the processor may output or trigger an output signal that audibly and/or visually indicates to a user that the optical sensor should be adjusted for a proper application to a measurement site.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: January 18, 2022
    Assignee: Masimo Corporation
    Inventors: Ryan Timothy McHale, Walter M. Weber
  • Patent number: 11221324
    Abstract: Disclosed herein are portable diagnostic measurement devices for determining at least one analysis parameter of a bodily fluid, in particular for determining an analyte concentration in a bodily fluid as can occur in blood glucose determinations. Also disclosed are analysis systems including the measurement device and at least one disposable test element. The test element can be designed as a carrier strip and can contact a receiving surface of the measurement device at least partially in a flat manner, where the receiving surface is arranged on a narrow side of the housing of the measurement device.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: January 11, 2022
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Heino Eikmeier, Hans-Peter Haar, Joachim Hoenes, Carina Horn, Ewald Rieger
  • Patent number: 11213819
    Abstract: A point-of-care medical testing system integrated with a patient monitor is disclosed. The system may include a microfluidic cartridge configured to receive a blood sample and generate a sensory signal dependent on a concentration of a biomarker in the blood sample. A cartridge reading assembly receives the microfluidic cartridge. The cartridge reading assembly includes a processing unit and a memory coupled with the processing unit. The memory stores executable instructions to cause the processing unit to receive the sensory signal, correlate the received sensory signal with the concentration of the biomarker in the blood sample, and produce an output representative of the concentration of the biomarker in the blood sample. The cartridge reading assembly is coupled to the patient monitor and configured to send the output to the patient monitor.
    Type: Grant
    Filed: January 30, 2018
    Date of Patent: January 4, 2022
    Inventors: Reza Kalantarinejad, Abdolreza Yaghoobzadeh Tari, Mahmoud Reza Merati, Ahmadreza Afraz, Soroor Yousefi Nassab Nobari, Vahid Jabi, Faranak Baniahmad, Mahsa Rastikerdar, Ali Akbar Pasha Zanoosi, Parisa Meyghani, Mohammad Amin Aghazadeh, Sepehr Ramezani
  • Patent number: 11202607
    Abstract: A technique for realizing energy saving. According to a biological information acquisition device, light emitting power per unit area of one light emitting element emitting light when first biological information is acquired is weaker than light emitting power per unit area of one light emitting element emitting light when second biological information is acquired.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: December 21, 2021
    Assignee: SEIKO EPSON CORPORATION
    Inventors: Yuiga Hamade, Yasunori Koide, Takashi Toya
  • Patent number: 11154203
    Abstract: Described herein are embodiments of systems and methods that utilize temperature measurements taken with head-mounted sensors as well as images of a user's face to detect fever and/or intoxication. One embodiment of a system to detect fever includes a first head-mounted temperature sensor that measures skin temperature (Tskin) at a first region on a user's head, a second head-mounted temperature sensor that measures a temperature of the environment (Tenv), and a computer. The computer receives images of a second region on the user's face, captured by a camera sensitive to wavelengths below 1050 nanometer, and calculates, based on the images, values indicative of hemoglobin concentrations at three or more regions on the user's face. The computer can then detect whether the user has a fever based on Tskin, Tenv and the values.
    Type: Grant
    Filed: September 1, 2020
    Date of Patent: October 26, 2021
    Assignee: Facense Ltd.
    Inventors: Ari M Frank, Arie Tzvieli, Ori Tzvieli, Gil Thieberger
  • Patent number: 11134894
    Abstract: The present invention relates to a device for measuring a physiological parameter of a human limb such as peripheral capillary oxygen saturation. The device comprises a body comprising a first body part and a second body part, which are movable relative to each other to define an opening with an adjustable size for receiving the limb therein, and a physiological sensor for interacting with the limb received in the opening, the sensor being attached to the body, wherein the first and second body parts are slidable or twistable relative to each other while at least partially engaging or intersecting each other, or wherein the first and second body parts are configured to form a clip having an L-shaped end section for at least partially enclosing the limb received in the opening, in order to adjust the size of the opening.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: October 5, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Wouter Herman Peeters, Sandra Liliana Ramirez Herrera, Ernest Roderick Laman, Ceren Bagatar, Pavankumar Murll Dadlani Mahtani, Suzanne Danielle Van Der Zaan-Landwehr Johan, Eckhardt Henricus Matheus Schraven
  • Patent number: 11129557
    Abstract: Embodiments herein relate to chemical sensors for detecting a physiological analyte. In an embodiment, an implantable medical device including a chemical sensor for detecting an ion concentration in a bodily fluid is provided. The chemical sensor can include a sensing element having an outer barrier layer forming a top, a bottom, and opposed sides, where the top of the outer barrier layer can be created from a polymeric matrix permeable to sodium ions, potassium ions, and hydronium ions. An active agent can be disposed within the top of the outer barrier layer, the active agent having anti-inflammatory effects. The chemical sensor can include an optical excitation assembly configured to illuminate the sensing element. The chemical sensor can also include an optical detection assembly configured to receive light from the sensing element. Other embodiments are also included herein.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: September 28, 2021
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Yingbo Li, Michael John Kane, Jeffrey E. Stahmann, Keith R. Maile
  • Patent number: 11096592
    Abstract: A sensor module includes a light emitter that emits light beams including near-infrared light beams towards a subject; a light receiver that receives light beams having passed through the subject; and a controller that estimates biological information based on signals output from the light receiver. The light emitter includes a plurality of light emitting elements that emit near-infrared light beams having central wavelengths different from each other. The light emitter produces sets of light emissions by causing the plurality of light emitting elements to sequentially and intermittently emit the near-infrared light beams. In given two consecutive sets of light emissions produced by the light emitter, a second non-light-emission period of time T4 is longer than a first non-light-emission period of time T2. The controller estimates the biological information in a processing period of time T41 that is set in correspondence with the second non-light-emission period of time T4.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: August 24, 2021
    Assignees: ALPS ALPINE CO., LTD., Genial Light CO., LTD.
    Inventors: Yukio Otaki, Toshio Kawano, Naoki Ito, Ryo Shimokita
  • Patent number: 11076805
    Abstract: A wearable diagnostic device worn on a user's body that can provide various types of health-related information to the user is described. The wearable diagnostic device can provide real-time, non-invasive, accurate, and continuous data regarding a user's heart rate, hemoglobin level, body temperature, oxygen level, glucose level, and blood pressure. In some implementations, the wearable diagnostic device may also provide electrocardiogram (EKG) data or detection of Parkinson's symptoms, such as the involuntary movement of a user's hand. A user may configure the wearable diagnostic device to provide information on one, multiple, or all of the health-related information noted above.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: August 3, 2021
    Inventor: Saleem Sayani
  • Patent number: 11058333
    Abstract: A system includes an enclosure having a processor and a memory coupled to the processor. The enclosure includes a display coupled to the processor where the display is visible from an exterior of the enclosure; and a battery within the enclosure coupled to the processor and the display. The enclosure includes a probe tip coupled to an exterior of the enclosure. The probe tip includes first, second, and third sensor openings. A first distance between the first and second sensor openings is different than a second distance between the first and third sensor openings. The enclosure includes code stored in the memory where the code is executable by the processor, and includes code to receive first data associated with the first and second sensor openings, code to receive second data associated with the first and second sensor openings, and code to perform SRS using the first and the second data.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: July 13, 2021
    Assignee: ViOptix, Inc.
    Inventors: Kate LeeAnn Bechtel, Joseph Heanue, Lester John Lloyd, Edward Solomon
  • Patent number: 11051728
    Abstract: An apparatus comprising: a light detector; a light source, laterally offset from the light detector by a first lateral offset; optics configured to receive light emitted by the light source and output the received light, wherein a majority of the light output is directed towards an offset region laterally offset from the light detector by at least a second lateral offset different from the first lateral offset.
    Type: Grant
    Filed: June 2, 2016
    Date of Patent: July 6, 2021
    Assignee: NOKIA TECHNOLOGIES OY
    Inventors: Harri Lasarov, Antti Salo, Teemu Ahmaniemi
  • Patent number: 11033209
    Abstract: A system and method to measure blood oxygenation levels and total hemoglobin on individually selected blood vessels, to provide a representation of the subject condition and of tissue perfusion that may be used for diagnosing specific tissue conditions. Reflection spectra from individual blood vessels or a collection of vessels are measured by using wide-field imaging for selecting target vessels and a narrow-field confocal detection system to enable measuring local blood oxygenation and hemoglobin. Optical fibers may be used to illuminate the target vessel and to detect light diffusively reflected therefrom. The reflection spectra may be analyzed in a spectrometer to extract the ratio of the deoxy- to oxyhemoglobin and to determine their absolute concentration for computing total hemoglobin levels. An alternative implementation uses image processing on camera images of a blood vessel, generated at an isosbestic wavelength of the deoxy- and oxyhemoglobin, and optionally also at neighboring wavelengths.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: June 15, 2021
    Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED
    Inventor: Dvir Yelin
  • Patent number: 11029189
    Abstract: A liquid surface detecting apparatus including: a retaining section that retains liquid as sample or reagent; a light emitter that emits light toward the liquid retained in the retaining section; an image capturing device that captures an image of the liquid retained in the retaining section; and a detecting device that detects a level of a liquid surface of the liquid retained in the retaining section based on the image of the liquid captured by the image capturing device, wherein the image capturing device is provided at a position such that the light, emitted by the light emitter and reflected by the liquid surface of the liquid, directly enters the image capturing device.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: June 8, 2021
    Assignees: SYSMEX CORPORATION, KAWASAKI JUKOGYO KABUSHIKI KAISHA
    Inventors: Yukio Iwasaki, Satoshi Ouchi, Eiji Mitsui, Junichi Matsuoka, Takehiro Hasegawa
  • Patent number: 10996173
    Abstract: Non-linear methods for quantitative elemental analysis and mineral classification using laser-induced breakdown spectroscopy are disclosed. According to one embodiment, a method, comprises calculating concentrations of elements in a sample using a laser-induced breakdown spectroscopy (LIBS) instrument. The LIBS instrument implements a kernel partial-least-squares regression (KPLSR) analysis. The method further comprises displaying the concentrations of the elements according to the KPLSR analysis.
    Type: Grant
    Filed: August 15, 2018
    Date of Patent: May 4, 2021
    Assignee: SETI INSTITUTE
    Inventor: Pablo Sobron
  • Patent number: 10987055
    Abstract: A substance concentration monitoring method includes inserting a temperature probe noninvasively into a volume of a body in which a concentration of a substance is to be measured. An internal temperature of the volume is measured and an internal temperature signal is produced. An incident first near infrared beam in a first wavelength band is directed from a light source into a portion of the volume, the first wavelength band including a wavelength at which an absorption peak exists in a NIR absorption spectrum of the substance. An incident second NIR beam in a second wavelength band is directed from the light source into the portion of the volume, the substance exhibiting no absorption or negligible absorption in the second wavelength band. Substance concentration is calculated based on values corresponding to the internal temperature signal, a first and second initial power signal, and a first and second material absorption signal.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: April 27, 2021
    Assignee: GlucoVista Inc.
    Inventor: Yonatan Gerlitz
  • Patent number: 10962524
    Abstract: An integrated system for determining a hemostasis and oxygen transport parameter of a blood sample, such as blood, is disclosed. The system includes a measurement system, such as an ultrasonic sensor, configured to determine data characterizing the blood sample. For example, the data could be displacement of the blood sample in response to ultrasonic pulses. An integrated aspect of the system may be a common sensor, sample portion or data for fast and efficient determination of both parameters. The parameters can also be used to correct or improve measured parameters. For example, physiological adjustments may be applied to the hemostatic parameters using a HCT measurement. Also, physical adjustments may be applied, such as through calibration using a speed or attenuation of the sound pulse through or by the blood sample. These parameters may be displayed on a GUI to guide treatment.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: March 30, 2021
    Assignee: HomoSonics LLC
    Inventors: Francesco Viola, William F. Walker
  • Patent number: 10957179
    Abstract: A method and system for communicating estimated blood loss parameters of a patient to a user, the method comprising: receiving data representative of an image, of a fluid receiver; automatically detecting a region within the image associated with a volume of fluid received at the fluid receiver, the volume of fluid including a blood component; calculating an estimated amount of the blood component present in the volume of fluid based upon a color parameter represented in the region, and determining a bias error associated with the estimated amount of the blood component; updating an analysis of an aggregate amount of the blood component and an aggregate bias error associated with blood loss of the patient, based upon the estimated amount of the blood component and the bias error; and providing information from the analysis of the aggregate amount of the blood component and the aggregate bias error, to the user.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: March 23, 2021
    Assignee: Gauss Surgical, Inc.
    Inventors: Siddarth Satish, Andrew T. Hosford, Kevin J. Miller, Milton McColl, Juan Carlos Aragon
  • Patent number: 10918320
    Abstract: A method for predicting a blood glucose level using a near-Infrared (NIR) spectrometer is provided. The method may include obtaining a feature set from an NIR glucose spectra; and predicting glucose values from the feature set based on a binary classification of the NIR glucose spectra and an in-class prediction of glucose using Machine Learning Regression.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: February 16, 2021
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Sujit Jos, Kiran Bynam, So Young Lee, Gorish Aggarwal, Srikanth Mallavarapu Rama
  • Patent number: 10905375
    Abstract: A monitor system configured to selectively attach a light emitter assembly and a light receiver assembly to a finger. The monitor system comprising the light emitter assembly, the light receiver assembly, an upper assembly a lower assembly, and an intermediate support. The monitor system comprises an attached portion and a detached portion. The attached portion is configured to attach to a fingernail of the finger. The detached portion is configured to selectively and releasably attach to the attached portion. The monitor system is configured to emit one or more emitted lights through the finger between the light emitter assembly and the light receiver assembly.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: February 2, 2021
    Inventor: Kenneth Ehrlich
  • Patent number: 10881336
    Abstract: A solution containing a target molecule and a reference molecule is illuminated to obtain Raman signals. An optical metasurface is used as a diffractive optical element to split the Raman signal from the target molecule and the Raman signal from the reference molecule. The target and reference Raman signals can be detected at different locations with different photodetectors, and the target molecule concentration in the solution is determined by comparing the target and reference Raman signals.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: January 5, 2021
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Andrei Faraon, Amir Arbabi, Yu Horie
  • Patent number: 10874348
    Abstract: The present disclosure generally relates to wearable devices and methods for measuring a photoplethysmographic signal. The wearable devices and methods may include a force sensor that provides input used for motion-noise filtering to obtain improved PPG signals. Feedback from the force sensor may also be used to indicate whether the amount of pressure exerted by the device should be adjusted, or whether the device should be switched to a locked state.
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: December 29, 2020
    Assignee: Apple Inc.
    Inventors: Chin San Han, Vivek Venugopal, Ueyn L. Block, Nicholas Paul Joseph Allec
  • Patent number: 10863937
    Abstract: A method for calibration of a photoplethysmographic device including the steps of providing a fluid circuit (305) for blood or other liquid, a pump mechanism (310) to generate pulsatile flow of blood through the fluid circuit, a sample of excised tissue (315) in the fluid circuit through which the blood flows, and a photoplethysmographic device including an emitter and a photodetector (330) positioned on the tissue (335, 340) so that a portion of the light output by the emitter passes through the tissue and is incident on the photodetector. The method further includes the steps of energizing the pump mechanism (420) to move the blood through the tissue, energizing the emitter (425) to output light, collecting paired data from the photodetector and from one or more reference measurements (430), and processing the paired data to calibrate the photoplethysmographic device (435).
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: December 15, 2020
    Assignee: Kestrel Labs, Inc
    Inventor: Jonas Alexander Pologe
  • Patent number: 10849508
    Abstract: The present invention describes a system and method for continuous monitoring of central (aortic) and peripheral Blood Pressure. The system includes a fully mobile, non-invasive, continuous blood pressure monitoring system that includes one or more Biostrip devices affixed on a user, coupled with an application running on a computing device, which is further connected to a web server in the cloud. The system performs various computations on the Biostrip device, or on the gateway device (Smartphone or Smartwatch), or on the Cloud, and provides the user and authorized third parties with various insights about the blood pressure levels of the user. Further, the system enables the user to receive biofeedback training for controlling hypertension, and schedule online appointments, pay online for such appointments, share data the data securely to obtain insights.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: December 1, 2020
    Assignee: Fourth Frontier Technologies Pvt. Ltd.
    Inventors: Manav Bhushan, Sandeep Sibal
  • Patent number: 10791982
    Abstract: A computer based method and system forms measurements of brain function and predictions of a likelihood for memory impairment via the use of cameras, including a near-infrared (NIR) spectroscopic device and a camera capturing images in the Red-Green-Blue (RGB) spectrum. The device acquires from a subject measurements of ions, molecules, or combinations thereof at more than one moment in time, as well as amplitude and timing of blood pulsations. Based on the measured molecule or ion concentration, flow, and so forth, a processor assesses the probability of a neuron to form an action potential. Formation of an action potential increases the probability that the subject individual will create a memory.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: October 6, 2020
    Inventor: Stephanie Littell
  • Patent number: 10794942
    Abstract: A spectrum processing apparatus includes: a spectrum obtainer configured to obtain an optical spectrum from a light that is scattered or reflected from a subject; and a processor configured to split the optical spectrum into a plurality of bands, determine, based on a predetermined measurement accuracy for measuring a biosignal from the light, one or more key bands from the plurality of bands, and obtain the biosignal from the determined key bands.
    Type: Grant
    Filed: February 8, 2018
    Date of Patent: October 6, 2020
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Yun S Park, Sung Mo Ahn
  • Patent number: 10791255
    Abstract: A scanning optical system is provided including a source of optical radiation; an optical scanning beam delivery system for delivering optical radiation to a subject, wherein the optical scanning beam delivery system includes a plurality of optical elements including at least one steerable mirror; at least one actuator coupled to the at least one steerable mirror; a detection system for detecting optical radiation returned from a subject; a communications device including a user interface and configured to process a set of instructions at least partially responsive to inputs from the user interface; a controller comprising memory, a microcontroller and an field programmable gate array (FPGA), the microcontroller and FPGA receiving instructions derived from the communications device; and at least one actuator coupled to the at least one steerable mirror.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: September 29, 2020
    Assignee: Leica Microsystems Inc.
    Inventors: Mehran Ghofrani, Al-Hafeez Z. Dhalla, Christopher Saxer
  • Patent number: 10772542
    Abstract: A method and an apparatus for separating a composite signal into a plurality of signals is described. A signal processor receives a composite signal and separates a composite signal into separate output signals. Feedback from one or more of the output signals is provided to a configuration module that configures the signal processor to improve a quality of the output signals. In one embodiment, calibration data from multiple calibration data sets is used to configure the demodulation of the composite signal into separate output signals.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: September 15, 2020
    Assignee: Masimo Corporation
    Inventors: Walter M. Weber, Ammar Al-Ali, Mohamed K. Diab, Marcelo M. Lamego
  • Patent number: 10768165
    Abstract: An imaging system for measuring water and blood lipid content in a tissue sample includes a light source configured to emit a plurality of sequential wavelengths of light within a predetermined range of wavelengths, a spatial modulation device configured to direct each of the plurality of sequential wavelengths of light onto a tissue sample plane to generate a first plurality of patterns on the issue sample plane at a first spatial frequency and a second plurality of patterns on the tissue sample plane at a second spatial frequency, an imaging device configured to generate first image data reproducible as images the first plurality of patterns and second image data reproducible as images the second plurality of patterns, and a controller configured to determine a first optical property and a second optical property for each location on the sample plane.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: September 8, 2020
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Darren Roblyer, Yanyu Zhao
  • Patent number: 10751433
    Abstract: A method and system for treating a biological fluid within a container by subjecting the container to light is provided. The system includes a fluid treatment chamber for receiving the container of biological fluid; an agitation assembly for oscillating the container of biological fluid within the fluid treatment chamber including a variable speed motor; one or more light sources in proximity to the fluid treatment chamber; at least one sensor for sensing a condition of the biological fluid in the container; and a programmable controller.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: August 25, 2020
    Assignee: Fenwal, Inc.
    Inventors: Brett T. Crawley, Kyungyoon Min
  • Patent number: 10753862
    Abstract: In a method and apparatus, a property of an optically diffuse medium including a first optical absorber having a first concentration and a second optical absorber having a second concentration is determined. A surface area of the medium is imaged at multiple wavelengths around an isosbestic wavelength of the first absorber and the second absorber. A reflectance spectrum of the medium at the surface area at the multiple wavelengths is determined. A derivative of the determined reflectance spectrum around the isosbestic wavelength is determined. From the derivative, a concentration ratio of the first concentration and the second concentration is estimated.
    Type: Grant
    Filed: February 14, 2017
    Date of Patent: August 25, 2020
    Assignee: Stichting Het Nederlands Kanker Instituut-Antoni Van Leeuwenhoek Ziekenhuis
    Inventors: Theodoor Jacques Marie Ruers, Esther Kho, Henricus Josephus Cornelus Maria Sterenborg
  • Patent number: 10743802
    Abstract: A biological signal acquirer is attached to a subject and acquires a biological signal of the subject. A transmitter carried by the subject transmits the biological signal. A first communication port and a first camera are installed in a first location and connectable to a network. A second communication port and a second camera are installed in a second location and connectable to the network. A biological information acquiring device is connectable to the network and provided with a switcher. The switcher acquires, when communication establishment between the transmitter and the first communication port is detected, the biological signal through the first communication port as well as a first image taken by the first camera, and acquires, when communication establishment between the transmitter and the second communication port is detected, the biological signal through the second communication port as well as a second image taken by the second camera.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: August 18, 2020
    Assignee: NIHON KOHDEN CORPORATION
    Inventor: Nobuyoshi Watanabe
  • Patent number: 10705139
    Abstract: A semiconductor device inspection system (1) includes a laser beam source (2), for emitting light, an optical sensor (12) for detecting the light reflected by the semiconductor device (10) from the light and outputting a detection signal, a frequency band setting unit (16) for setting a measurement frequency band and a reference frequency band with respect to the detection signal, a spectrum analyzer (15) for generating a measurement signal and a reference signal from the detection signals in the measurement frequency band and the reference frequency band, and a signal acquisition unit (17) for calculating a difference between the measurement signal and the reference signal to acquire an analysis signal. The frequency band setting unit (16) sets the reference frequency band to a frequency domain in which a level of the detection signal is lower than a level obtained by adding 3 decibels to a white noise level serving as a reference.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: July 7, 2020
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventor: Tomonori Nakamura
  • Patent number: 10702173
    Abstract: A system and method for camera-based heart rate tracking. The method includes: determining bit values from a set of bitplanes in a captured image sequence that represent the HC changes; determining a facial blood flow data signal for each of a plurality of predetermined regions of interest (ROIs) of the subject captured by the images based on the HC changes; applying a band-pass filter of a passband approximating the heart rate to each of the blood flow data signals; applying a Hilbert transform to each of the blood flow data signals; adjusting the blood flow data signals from revolving phase-angles into linear phase segments; determining an instantaneous heart rate for each the blood flow data signals; applying a weighting to each of the instantaneous heart rates; and averaging the weighted instantaneous heart rates.
    Type: Grant
    Filed: July 9, 2019
    Date of Patent: July 7, 2020
    Assignee: NuraLogix Corporation
    Inventors: Kang Lee, Evgueni Kabakov, Phil Levy
  • Patent number: 10695005
    Abstract: The present invention discloses a non-invasive blood glucose measurement method, applied to noninvasive blood glucose measuring instruments including measuring hosts and fingertip measuring probes, comprising pre-storing a random forest algorithm and a neural network prediction algorithm in the measuring host; measuring energy metabolism parameters of a fingertip of an individual to be measured and transmitting the parameters to the measuring host by the fingertip measuring probe; calling the random forest algorithm to predict the blood glucose type of the energy metabolism parameters of the fingertip of the individual to be measured and calling the corresponding neural network prediction algorithm to calculate the blood glucose value of the fingertip of the individual to be measured by the measuring host. The present invention also provides a fingertip-measuring probe.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: June 30, 2020
    Assignees: Guilin Medicine Electronic Technology Co., Ltd., Guilin University of Electronic Technology
    Inventors: Zhencheng Chen, Jianming Zhu, Yongbo Liang, Shimin Yin, Guocheng Han, Biao Xu, Yang Zhang
  • Patent number: 10691072
    Abstract: A wearable device can include an electronic device and a band for securing the electronic device to the user. The electronic device can detect an identification of the band, which can serve as an input to initiate actions performed by the electronic device. For example, a type, model, color, size, or other characteristic of a band can be determined and used to select a corresponding action performed by the electronic device. Identification of the band can be performed by components of the electronic device that also serve other purposes. Existing sensors, communication elements, and/or detectors can be used to detect and identity a band provided to the electronic device. The electronic device can respond to the identification of a particular band by performing particular functions, such as changing an aspect of a user interface or altering settings of the electronic device.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: June 23, 2020
    Assignee: Apple Inc.
    Inventor: Timothy M. Johnson
  • Patent number: 10674962
    Abstract: A finger clamping device and an oximeter using the finger clamping device are provided. The finger clamping device includes a shell, an upper clamping member, and a lower clamping member. The shell includes two oppositely facing sidewalls. Each sidewall defines at least one sliding rail. The upper clamping member is arranged in the shell and defines two guiding rods. The two guiding rods are received in and slide along the sliding rail. At least one elastic member joins the lower clamping member and the upper clamping member and is tensioned when a finger is inserted between the upper clamping member and the lower clamping member.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: June 9, 2020
    Assignee: Hangzhou Jiangyu Innovation Medical Technology CO., LTD
    Inventors: Zhan-Sheng Lu, Yu-Chun Sun