Abstract: A neural interface arrangement has multiple probes for subdural implantation into or onto a human brain. Each probe has at least one sensing electrode, a coil for receiving power via inductive coupling, signal processing circuitry coupled to the electrode(s), and a transmitter for wirelessly transmitting data signals arising from the electrode(s). An array of coils is implanted above the dura beneath the skull, for inductively coupling with the coil of each probe, and for transmitting power to the probes. A primary coil is connected to the coil array, for inductively coupling with an external transmitter device, and for receiving power from the external transmitter device. In use, the primary coil is operable to receive power from the external transmitter device by inductive coupling and to cause the coil array to transmit power to the probes by inductive coupling, and the probes wirelessly transmit data signals arising from the electrodes.

Abstract: A medical device includes a printed circuit board-battery assembly, a tape encapsulation assembly wrapped around the PCB-battery assembly, and a second removable tab positioned on a surface of the tape encapsulation assembly. The second removable tab provides an adhesive layer on a surface of the medical device when the second removable tab is removed from the medical device. The PCB includes the electronic circuitry that performs the functionalities of the medical device, including an optical sensor that comprises at least one light source to emit light towards a measurement site of a user and at least one photodetector to receive light returned from the measurement site. The medical device can connect to a host computing device that performs various operations, including, but not limited to, authenticating the medical device, causing measurement values such as blood oxygen saturation (SpO2), pulse rate (PR), and a perfusion index (PI) to be provided.

Abstract: The invention relates to an optical stimulation device for stimulating nerve cells, wherein the stimulation device has at least one implant component, which is designed for implanting in a natural inner cavity of the body of a living being, through which cavity a bodily fluid flows, having the following features: a) the implant component has at least one supporting structure, which can be expanded in a radial direction for fastening in the natural inner cavity, b) a plurality of light sources is fastened to the supporting structure, which light sources are designed to emit light in the radial direction with respect to the supporting structure, c) a plurality or electrodes is fastened to the supporting structure, which electrodes are designed to capture electrical body signals, d) the supporting structure has a plurality of openings and/or channels, through which the bodily fluid can flow after implantation in the body.

Abstract: An example method for performing pulse oximetry can commence with receiving at least three light signals of three different wavelengths reflected from a human tissue. The human tissue includes a pulsatile tissue and a non-pulsatile tissue. Based on the three light signals, values of at least three functions are determined. The three functions are invariant to an oxygen saturation in the pulsatile tissue and depend on location of a sensor operable to detect the three light signals and pressure of the sensor on the human tissue. Based on the values of the three functions, non-pulsatile components are analyzed for intensities of a red light signal and infrared light signal reflected from the human tissue. The non-pulsated components are removed from the intensities to allow correct estimates of a ratio of the absorption coefficients, with the ratio being used to determine the oxygen saturation in the pulsatile tissue.

Abstract: The invention relates to a photoplethysmography (PPG) apparatus (100), comprising at least one light source (110) configured to generate a beam of source light (114) having a source beam angle (118) and at least one controllable beam angle adapter (120) configured to receive a beam-angle control signal (170) indicative of a modified beam angle (124) to be set, the beam angle adapter (120) being further configured to provide the beam of source light (114) with a modified beam angle (124) to an external object (130). The PPG apparatus (100) comprises at least one PPG sensor(140)configured to provide a sensor signal (145) indicative of source light (150) scattered by the external object (130), and a PPG evaluation and control unit (160) configured to receive the sensor signal (145), to provide the beam-angle control signal (170) and to provide at its output (180) an AC signal component of the sensor signal (145).

Abstract: A neural probe structure includes a probe which is inserted into a living body, and a magnetic field inductor which is formed in the probe, wherein when a power source is supplied, the magnetic field inductor generates a magnetic field and applies magnetic stimulation to a target site of the living body into which the probe is inserted. A method for manufacturing the neural probe structure includes forming a first pattern on a first substrate and filling the first pattern with a conductor, stacking a second substrate on the first substrate, and forming a second pattern connected to the first pattern on the second substrate and filling the second pattern with a conductor, wherein the first substrate and the second substrate form the probe, and the conductor of the first pattern and the conductor of the second pattern form the magnetic field inductor.

Abstract: Systems and methods for restoring cognitive function are disclosed. In some implementations, a method includes, at a computing device, separately stimulating one or more of lateral and medial entorhinal afferents and other structures connecting to a hippocampus of an animal subject in accordance with a plurality of predefined stimulation patterns, thereby attempting to restore object-specific memories and location-specific memories; collecting a plurality of one or more of macro- and micro-recordings of the stimulation of hippocampalentorhinal cortical (HEC) system; and refining the computational model for restoring individual memories in accordance with a portion of the plurality of one or more of macro- and micro-recordings.

Abstract: In a biological information processing apparatus, a variation index value calculation section calculates a variation index value on the basis of a plurality of measured values obtained by measuring biological information of a subject. A display data generation section generates display data which is used to display a measurement result and undergoes identification display corresponding to the variation index value.

Abstract: A medical device such as an oximeter includes a marking feature. In an implementation, a marking mechanism of the device marks tissue based on a location of where a measurement was taken by the device. In an implementation, the marking mechanism of the device marks tissue based on an oxygen saturation measurement obtained by the device.

Abstract: A device includes a first sensor coupler that is configured to receive a first input signal from a first sensor. The first input signal corresponds to a first physiological parameter and is based on optical excitation of a tissue. The device includes a processor coupled to the first sensor coupler. The processor is configured to generate an output signal based on the first input signal. The first physiological parameter is encoded in the output signal. The output signal differs from the first input signal. The device includes an output coupler configured to communicate the output signal to a remote device.

Abstract: A patient monitor has multiple sensors adapted to attach to tissue sites of a living subject. The sensors generate sensor signals that are responsive to at least two wavelengths of optical radiation after attenuation by pulsatile blood within the tissue sites.

Abstract: Systems and methods are disclosed herein for measuring the electromechanical delay of the heart of a patient. An electrocardiogram (EKG) signal may be used to detect heart electrical activity. Photoplethysmograph (PPG) signals may be used to detect heart mechanical activity. The electromechanical delay may be calculated based at least in part on the timing of an EKG signal and at least two PPG signals.

Abstract: Methods and systems are provided that allow for the simultaneous calculation of pulse and regional blood oxygen saturation. An oximeter system that includes a sensor with a plurality of emitters and detectors may be used to calculate a pulse and/or regional blood oxygen saturation. A plurality of light signals may be emitted from light emitters. A first light signal may be received at a first light detector and a second light signal may be received at a second light detector. A pulse and/or regional blood oxygen saturation value may be calculated based on the received first and/or second light signals. The pulse and regional blood oxygen saturation values may be calculated substantially simultaneously. The calculated pulse and regional blood oxygen saturation values as well as other blood oxygen saturation values may be displayed simultaneously in a preconfigured portion of a display.

Abstract: Methods, sensors, and systems for determining a concentration of glucose in a medium of a living animal are disclosed. Determining the glucose concentration may involve emitting excitation light from a light source to indicator molecules, generating a raw signal indicative of the amount of light received by a photodetector, purifying and normalizing the raw signal, and converting the normalized signal to a glucose concentration. The purification may involve removing noise (e.g., offset and/or distortion) from the raw signal. The purification and normalization may involve tracking the cumulative emission time that the light source has emitted the excitation light and tracking the implant time that has elapsed since the optical sensor was implanted. The purification and normalization may involve measuring the temperature of the sensor. The purification, normalization, and conversion may involve using parameters determined during manufacturing, in vitro testing, and/or in vivo testing.

Abstract: A sensor adapter cable provides medical personnel with the convenience of utilizing otherwise incompatible optical sensors with multiple blood parameter plug-ins to a physiological monitor, where the plug-ins each have keyed connectors that mechanically lock-out incompatible sensors in addition readers that poll sensor identification components in each sensor so as to electrically lock-out incompatible sensors.

Abstract: A reflection-detector sensor position indicator comprises emitters that transmit light having a plurality of wavelengths. A detector outputs a sensor signal. At least one reflection detector outputs at least one sensor position signal. An attachment assembly attaches the emitters, the detector and the reflection detector onto a tissue site. A sensor-on condition indicates that the attachment assembly has positioned the emitters generally centered over a fingernail, the detector on a fingertip opposite the fingernail and the reflection detector over the fingernail. The sensor signal, in the sensor-on condition, is at least substantially responsive to the emitter transmitted light after attenuation by pulsatile blood flow perfused within a fingernail bed underneath the fingernail. The sensor position signal, in the sensor-on condition, is at least substantially responsive to the emitter transmitted light after reflection off of the fingernail.

Abstract: The present disclosure relates generally to patient monitoring systems and, more particularly, to a resistance emulator for patient monitors. In an embodiment, a resistance emulator includes a first plug configured to couple with a medical monitor. The medical monitor is configured to receive a calibration resistance value of a medical device sensor from a coded resistor. The resistance emulator further includes a second plug configured to couple with a medical device sensor. The medical device sensor is configured without the coded resistor. The resistance emulator also includes emulation circuitry configured to provide an emulated signal representative of the calibration resistance value to the medical monitor.

Abstract: Embodiments disclosed herein may include an adapter which is capable of converting signals from an oximeter sensor such that the signals are readable by an oximeter monitor. In an embodiment, the adapter is capable of converting signals relating to calibration information from the oximeter sensor. The calibration information may relate to wavelengths of light emitting diodes within the oximeter sensor. In a specific embodiment, the adapter will convert wavelength calibration information in a first form relating to data values stored in a digital memory chip to a second form relating to a resistance value of an expected resistor within the oximeter sensor.

Abstract: In accordance with one aspect of the present technique, a method is disclosed. The method includes receiving continuous photoplethysmographic (PPG) data of a subject from a sensor and calculating a continuous blood characteristic (BC) based on the continuous PPG data. The method also includes calculating a first quality metric of the continuous PPG data based on a sequence of the continuous BC. The method further determines whether the first quality metric satisfies a stability criterion and sending a first notification to the sensor in response to determining that the first quality metric satisfies the stability criterion. The first notification instructs the sensor to collect compressed PPG data of the subject.

Abstract: According to the present invention, a method and apparatus for non-invasively determining the blood oxygen saturation level within a subject's tissue is provided. The method includes the steps of: a) providing a spectrophotometric sensor operable to transmit light into the subject's tissue, and to sense the light; b) detecting light after passage through the subject's tissue using the sensor, and producing initial signal data from the light sensed; c) calibrating the sensor to that particular subject using the initial signal data, thereby accounting for the specific physical characteristics of the particular subject's tissue being sensed; and d) using the calibrated sensor to determine the blood oxygen parameter value within the subject's tissue.

Abstract: Aspects of the present disclosure include a sensor configured to store in memory indications of sensor use information and formulas or indications of formulas for determining the useful life of a sensor from the indications of sensor use information. A monitor connected to the sensor monitors sensor use and stores indications of the use on sensor memory. The monitor and/or sensor compute the useful life of the sensor from the indications of use and the formulas. When the useful life of the sensor is reached, an indication is given to replace the sensor.

Abstract: There is provided a system and method for canceling shunted light. The method includes transmitting electromagnetic radiation at tissue of interest and generating a signal representative of detected electromagnetic radiation. A portion of the generated signal representing shunted light is canceled from the generated signal and the remaining portion of the generated signal is used to compute physiological parameters.

Abstract: A physiological parameter system has one or more parameter inputs responsive to one or more physiological sensors. The physiological parameter system may also have quality indicators relating to confidence in the parameter inputs. A processor is adapted to combine the parameter inputs, quality indicators and predetermined limits for the parameters inputs and quality indicators so as to generate alarm outputs or control outputs or both.

Abstract: Various methods and systems for obtaining calibration coefficients for pulse oximeter sensors are provided. A method includes passing current through a light emitting element in an oximeter sensor and measuring, utilizing a first voltage sensing lead, a first voltage present at an electrical input of the light emitting element. The method also includes measuring, utilizing a second voltage sensing lead, a second voltage present at an electrical output of the light emitting element and determining a forward voltage of the light emitting element based on the first and second voltages. Utilizing the determined forward voltage, a wavelength of light emitted from the light emitting element is calculated. Utilizing the calculated wavelength of the emitted light, at least one calibration coefficient for the oximeter sensor is determined.

Abstract: A process and apparatus for determining the arterial and venous oxygenation of blood in vivo with improved precision. The optical properties of tissue are measured by determination of differential and total attenuations of light at a set of wavelengths. By choosing distinct wavelengths and using the measured attenuations, the influence of variables such as light scattering, absorption and other optical tissue properties is canceled out or minimized.

Abstract: A system (100) includes a sensor (12A/B/C), a processor (32), and an output module (38). The sensor can have at least one light emitter (16A) and at least one light detector (18A/B). The processor can be coupled to the sensor and have instructions configured to determine a calibration value using light attenuation corresponding to a light path through a tissue associated with a light emitter and a light detector of the sensor. The processor can be configured to calculate oxygen saturation in the tissue using a signal provided by the sensor. The output module can be coupled to the processor and configured to render a compensated oxygen saturation. The compensated oxygen saturation can be determined using the calibration value and the calculated oxygen saturation.

Abstract: A sensor has codes useful for a monitor which can be authenticated as accurate. The sensor produces a signal corresponding to a measured physiological characteristic and provides codes which can be assured of being accurate and authentic when used by a monitor. A memory associated with the sensor stores both data relating to the sensor and a digital signature. The digital signature authenticates the quality of the code by ensuring it was generated by an entity having predetermined quality controls, and ensure the code is accurate.

Abstract: A method and apparatus for non-invasively determining the blood oxygenation within a subject's tissue is provided that utilizes a near infrared spectrophotometric (NIRS) sensor capable of transmitting a light signal into the tissue of a subject and sensing the light signal once it has passed through the tissue via transmittance or reflectance.

Abstract: A method and an apparatus for separating a composite signal into a plurality of signals is described. A signal processor receives a composite signal and separates a composite signal in to separate output signals. Pre-demodulation signal values are used to adjust the demodulation scheme.

Abstract: A method for using a medical device comprising an optical sensor to measure calibrated oxygen saturation in a body tissue uses a standard spectral response of blood established for multiple of oxygen saturations and a standard spectral response of a reference material. The standard responses are established using a spectrometer. The spectral power output of the optical sensor is measured using a spectrometer. The optical sensor output signal response to the reference material is obtained. A processor computes a device-specific calibration curve for the medical device using the measured spectral power output and the standard spectral response of blood and computes an optical gain using the standard spectral response of the reference material and the measured spectral power output of the optical sensor. The device-specific calibration curve and optical gain of the optical sensor are stored in a memory of the medical device.

Abstract: Generally described, one or more embodiments of the present disclosure are directed to pulse oximeter test instruments for testing pulse oximeters. The pulse oximeter test instruments are configured to linearize a relationship between an input signal and an output signal of a light emitting diode (LED). In some embodiments, the linearized relationship may be obtained by minimizing an amount of ambient light detected by a photosensor in a feedback loop. The photosensor may be located in a housing that limits the amount of ambient light that may be detected.

Abstract: To make the peak value of the driving current of light source smaller than the conventional one and to make the peak value of the light receiving level of light-sensitive elements smaller than the conventional one in order to save power consumption of the device and to improve the precision of measurement, codes of which the bits of the Hadamard codes are shifted by the same bit for each code series having the same bit cycle, or codes of which the bits of a PN code are shifted are used as different codes.

Abstract: A calibration device according to embodiments of the disclosure is capable of being used with a non-invasive sensor. Certain embodiments of the calibration device simulate a human pulse by varying the volume of blood being measured by the optical sensor. Further, embodiments of the calibration device allow the generation of calibration curves or data for measured parameters over larger ranges of measured values compared to patient-based calibration.

Abstract: According to the present invention, a method and apparatus for non-invasively determining the blood oxygen saturation level within a subject's tissue is provided. The method comprises the steps of: a) providing a spectrophotometric sensor operable to transmit light into the subject's tissue, and to sense the light; b) detecting light after passage through the subject's tissue using the sensor, and producing initial signal data from the light sensed; c) calibrating the sensor to that particular subject using the initial signal data, thereby accounting for the specific physical characteristics of the particular subject's tissue being sensed; and d) using the calibrated sensor to determine the blood oxygen parameter value within the subject's tissue.

Abstract: Calibration phantom and method for measuring and correcting geometric distortions in an image of a body part of a patient Calibration phantom (5) for a medical imaging system, comprising a plurality of separate detection elements (20) arranged in a determined pattern, each detection element (20) containing a product that is visible by the medical imaging system.

Abstract: A method for calibrating detectors of a self-contained, tissue oximetry device includes emitting light from a light source into a tissue phantom, detecting in a plurality of detectors the light emitted from the light source, subsequent to reflection from the tissue phantom, and generating a set of detector responses by the plurality of detectors based on detecting the light emitted from the light source. The method further includes determining a set of differences between the set of detector responses and a reflectance curve for the tissue phantom, and generating a set of calibration functions based on the set of differences. Each calibration function in the set of calibration functions is associated with a unique, light source-detector pair. The method further includes storing the set of calibration function in a memory of the self-contained, tissue oximetry device.

Abstract: Systems, methods for manufacturing, and devices for producing an output current that simulates a current generated by an optical patient sensor are provided. An optical patient sensor includes a sensor light source having a first characteristic profile and a sensor photodetector having a second characteristic profile. The current source includes a light source having a characteristic profile similar to the first characteristic profile and indicative of interchangeability between the light source and the sensor light source, and a first photodetector configured to produce an output current in response to receiving light from the light source, the first photodetector having a characteristic profile similar to the second characteristic profile and indicative of interchangeability between the sensor photodetector and the first photodetector.

Abstract: Embodiments disclosed herein may include an adapter which is capable of converting signals from an oximeter sensor such that the signals are readable by an oximeter monitor. In an embodiment, the adapter is capable of converting signals relating to calibration information from the oximeter sensor. The calibration information may relate to wavelengths of light emitting diodes within the oximeter sensor. In a specific embodiment, the adapter will convert wavelength calibration information in a first form relating to data values stored in a digital memory chip to a second form relating to a resistance value of an expected resistor within the oximeter sensor.

Abstract: A secondary-emitter sensor position indicator has primary emitters that transmit light having primary wavelengths and at least one secondary emitter that transmits light having at least one secondary wavelength. A detector outputs a sensor signal in response to received light. An attachment assembly, in a sensor-on condition, positions the emitters and detector relative to a tissue site so that the sensor signal is substantially responsive to the primary wavelength light after attenuation by pulsatile blood flow within the tissue site and is negligibly responsive to the secondary wavelength light. The attachment assembly, in a sensor out-of-position condition, positions the secondary emitter relative to the tissue site so that the sensor signal is at least partially responsive to the secondary wavelength.

Abstract: A calibration device according to embodiments of the disclosure is capable of being used with a non-invasive sensor. Certain embodiments of the calibration device simulate a human pulse by varying the volume of blood being measured by the optical sensor. Further, embodiments of the calibration device allow the generation of calibration curves or data for measured parameters over larger ranges of measured values compared to patient-based calibration.

Abstract: Provided is a method of calibrating a pulse oximeter, in which the effects caused by tissue of a subject can be taken into account. A detector output signal is measured when living tissue of the subject is present between emitters and the detector in a sensor. Nominal calibration and nominal calibration characteristics are read from a memory, whereupon values for the same nominal characteristics for the sensor on living tissue of the subject are established using the detector output signal. Then, changes in the nominal calibration characteristics induced by the living tissue are calculated and a subject-specific calibration is formed by correcting the nominal calibration with the changes. Finally, the hemoglobin fractions are solved using the corrected nominal calibration.

Abstract: The present invention relates to a device for measuring blood and physiological characteristics by passing light through human tissue that is configured for deployment on a human finger. The device includes a lower finger-trough configured in the main housing of the device; a hingedly attached closeable lid that has an upper finger-trough configured for deployment of at least one finger stabilizing element, the lid being latchable in a closed position; a finger stabilizing element made of a material having flexibly soft malleable characteristics so as to sealingly engage the top of the finger; a light source that is deployed in the sloped end wall of the lower finger-trough adjacent to the lower portion of the finger tip; and an end cap the is deployable on the open end of the device when the lid is in the closed position, which enables calibration of the device with a minimum of light wave “noise” from ambient light.

Abstract: A first concentration of a chromophore corresponding to a measurement volume of an optical sensor is determined. A second concentration of the chromophore is obtained in the vicinity of the measurement volume corresponding to a change in at least one of a total concentration of the chromophore and a relative concentration of a first form of the chromophore to the total concentration of the chromophore in the measurement volume. Light remittance measurements including a first light wavelength and a second light wavelength are obtained corresponding to the first chromophore concentration and the second chromophore concentration. A coefficient for computing an index of a change in the chromophore concentration is computed using the difference between the first and second chromophore concentrations and the first and second light remittance measurements.

Abstract: A medical device for monitoring of oxygen saturation includes an optical sensor adapted for positioning adjacent to a tissue volume. The optical sensor has a light emitting portion capable of emitting light at a plurality of wavelengths and a light detecting portion capable of generating an electrical output signal corresponding to light incident on the detecting portion. A control module coupled to the optical sensor controls the light emitted by the light emitting portion. A monitoring module receives the output signal from the light detecting portion and computes a volume-independent measure of oxygen saturation in the volume of tissue using the output signal.

Abstract: A medical device for monitoring a patient condition includes a sensor capable of being advanced transvascularly to be positioned along a volume of tissue, the sensor including a first combination of a light source and a light detector to emit light into a volume of tissue and to detect light scattered by the volume of tissue and to generate a first output signal corresponding to an intensity of the detected light. A control module is coupled to the light source to control the light source to emit light at least four spaced-apart light wavelengths, and a monitoring module is coupled to the light detector to receive the output signal and compute a measure of tissue oxygenation using the light detector output signal.

Abstract: The present disclosure relates to systems and methods for analyzing and normalizing signals, such as PPG signals, for use in patent monitoring. The PPG signal may be detected using a continuous non-invasive blood pressure monitoring system and the normalized signals may be used to determine whether a recalibration of the system should be performed.

Abstract: A system for determining the concentration of an analyte in at least one body fluid in body tissue comprises an infrared light source, a body tissue interface, a detector, and a central processing unit. The body tissue interface is adapted to contact body tissue and to deliver light from the infrared light source to the contacted body tissue. The detector is adapted to receive spectral information corresponding to infrared light transmitted through the portion of body tissue being analyzed and to convert the received spectral information into an electrical signal indicative of the received spectral information. The central processing unit is adapted to compare the electrical signal to an algorithm built upon correlation with the analyte in body fluid, the algorithm adapted to convert the received spectral information into the concentration of the analyte in at least one body fluid.

Abstract: A method for using a medical device comprising an optical sensor to measure calibrated oxygen saturation in a body tissue uses a standard spectral response of blood established for multiple of oxygen saturations and a standard spectral response of a reference material. The standard responses are established using a spectrometer. The spectral power output of the optical sensor is measured using a spectrometer. The optical sensor output signal response to the reference material is obtained. A processor computes a device-specific calibration curve for the medical device using the measured spectral power output and the standard spectral response of blood and computes an optical gain using the standard spectral response of the reference material and the measured spectral power output of the optical sensor. The device-specific calibration curve and optical gain of the optical sensor are stored in a memory of the medical device.

Abstract: A calibration device according to embodiments of the disclosure is capable of being used with a non-invasive sensor. Certain embodiments of the calibration device simulate a human pulse by varying the volume of blood being measured by the optical sensor. Further, embodiments of the calibration device allow the generation of calibration curves or data for measured parameters over larger ranges of measured values compared to patient-based calibration.

Abstract: A method for determining a physiological parameter in the presence of correlated artifact, including obtaining two digital waveforms, x and y, the waveforms being representative of the absorption of two wavelengths of electromagnetic energy received from a blood-perfused tissue, and where each of the waveforms has a component corresponding to a plethysmographic waveform and a component corresponding to the correlated artifact; calculating several weighted difference waveforms of the form x?R*y, where R is a multiplier, by varying R over a range; evaluating the several weighted difference waveforms using a shape characteristic of the weighted difference waveform; identifying a weighted difference waveform most closely representative of and one most different from the plethysmographic waveform; determining a pleth-based physiological parameter using the waveform most closely representative of the plethysmographic waveform; determining at least one artifact-based physiological parameter using the waveform most d