Sweat Analysis Patents (Class 600/346)
  • Patent number: 9775565
    Abstract: A new system monitors ethanol alcohol levels of a vehicle operator by collecting sweat from the operator's hands, and detecting the presence, if any, of ethanol in the sweat. The system can then be used, if ethanol is present, to take action, such as immobile vehicle disablement, in the event of intoxication caused by an impermissibly high levels of ethanol of the operator. The system includes devices, referred to as pods in the description, which are sweat-collecting devices that are attached to the steering wheel of the vehicle. If the measurable ethanol in collected moisture from the operator's hands exceeds a preset threshold, the system could be configured to warn the operator to park the vehicle thereafter to disable operation of the vehicle, but if the operator does not so discontinue operation of the vehicle hazard warning lights and audible warnings within and without the vehicle will be activated alerting near vehicles of a dangerous vehicle being operated in close proximity.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: October 3, 2017
    Inventors: Tammy Berg-Neuman, James L Gowan
  • Patent number: 9636061
    Abstract: Systems and methods of analyzing biological fluid biomarkers, calculating biomarker data, transmitting data to a transceiver device, and storing the data and/or analytics in a database and/or on at least one remote computer server.
    Type: Grant
    Filed: February 3, 2016
    Date of Patent: May 2, 2017
    Assignee: CoreSyte, Inc.
    Inventors: Sten Adam Nyberg, Dalton Pont
  • Patent number: 9579024
    Abstract: Systems and methods of analyzing biological fluid biomarkers, calculating biomarker data, transmitting data to a transceiver device, and storing the data and/or analytics in a database and/or on at least one remote computer server.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: February 28, 2017
    Assignee: CoreSyte, Inc.
    Inventors: Sten Adam Nyberg, Dalton Pont
  • Patent number: 9000928
    Abstract: A system and method for effectively communicating information using at least one mode of communication is described, in which information recipients proximate to a communications device within a pre-determined space and during a pre-determined time period are identified, from whom physiological state information is obtained that, when coupled with other characteristics information, is used to select from a plurality of information elements at least one information element to better target the information elements. The information element is then provided to the communications device so that it may be provided to the information recipients in the pre-determined space in a manner that is sensed by the information recipients.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: April 7, 2015
    Inventor: Brian William Higgins
  • Publication number: 20150057516
    Abstract: Novel methods and systems for monitoring the health of an eye are disclosed. For example, a resonant circuit may be fabricated on a contact lens and this circuit may be coupled to a second circuit having the same resonant current frequency. A change in a property of the eye fluid contacted by the sensor in the contact lens is communicated to an external device and a remedying action is suggested to the wearer.
    Type: Application
    Filed: August 21, 2014
    Publication date: February 26, 2015
    Inventors: Muhammad MUJEEB-U-RAHMAN, Axel SCHERER
  • Publication number: 20150057515
    Abstract: Biological chemicals, potentially found in blood are measured by collecting sweat and determining the concentration or meaning of the selected chemical in sweat. The sweat can be collected using a time based, interval collector and analyzed using an external device. It can also be collected on a one time basis, using a flexible, chemical capacitor, or on a continuous basis using a chemical, field effect transducer.
    Type: Application
    Filed: April 3, 2013
    Publication date: February 26, 2015
    Applicant: University of Cincinnati
    Inventors: Joshua A Hagen, Jason C. Heikenfeld, Ian Papautsky, Linlin Hou, Rajesh Naik, Nancy Kelly-Loughnane, Morley Stone, John Busbee, Xiao Wang
  • Patent number: 8934954
    Abstract: A method for assessing sudomotor function of a patient for evaluating diabetic and autonomous neuropathy is disclosed. The method is performed in a system comprising electrodes intended to be placed on different regions of the patient body, and an adjustable DC source. The method includes applying on the electrodes DC voltage pulses of varying voltage values in order to stress sweat glands, the voltage pulses lasting given durations allowing the stabilization of electrochemical phenomena in the body, near the electrodes; collecting data representative of the current between the electrodes, and of the potential generated on the electrodes for the different DC voltages; from the data, computing results representative of the electrochemical skin conductance of the patient; reconciling the latter data with reference data obtained in the same conditions on patients identified as suffering or not from sudomotor, and identifying the patient as suffering or not from sudomotor dysfunction.
    Type: Grant
    Filed: August 23, 2011
    Date of Patent: January 13, 2015
    Assignee: Impeto Medical
    Inventors: Philippe Brunswick, Kamel Khalfallah, Jean Henry Calvet
  • Publication number: 20140257064
    Abstract: Embodiments of the invention include adhesive electrode sets and related methods. In an embodiment, the invention includes an adhesive electrode set. The adhesive electrode set can include a first pad, a first electrode, a first electrical contact, a first conductive lead, a second pad, a second electrode, a second electrical contact, a second conductive lead, a flexible strip, and an adhesive material. The flexible strip can include a fold. The flexible strip can be configured to allow the distance between the first pad and the second pad to increase through flexion of the flexible strip. In an embodiment, the invention includes an analyte receiving test patch. The analyte receiving test patch can include a skin contact layer, a wick, an absorbent layer, a barrier film layer, and an adhesive frame. Other embodiments are also included herein.
    Type: Application
    Filed: March 11, 2014
    Publication date: September 11, 2014
    Applicant: Birchwood Laboratories, Inc.
    Inventors: Cydney A. Einck, Nathan R. Erickson, Dennis Hepp, Gary A. Messer
  • Patent number: 8712495
    Abstract: A measurement device includes an electronic component device, a perspiration acceleration device, and a perspiration collection device. The perspiration acceleration device or the perspiration collection device is removably coupled to the electronic component device. The electronic component device is attached to a measurement site with a belt. A perspiration accelerating performance is made with respect to the measurement site with the perspiration acceleration device coupled to the electronic component device, and thereafter, the perspiration acceleration device is replaced with the perspiration collection device with the electronic component device attached to the measurement site, and the perspiration collection and measurement computation performance are made.
    Type: Grant
    Filed: May 7, 2010
    Date of Patent: April 29, 2014
    Assignee: Omron Healthcare Co., Ltd.
    Inventor: Muneo Tokita
  • Publication number: 20140012114
    Abstract: This application describes methods and apparatus for monitoring of fluid content that are suitable for in-situ, real time and/or continuous monitoring, especially of bodily fluids and in particular the content of sweat. The application also describes fabrication of such an apparatus. The apparatus comprises a multilayer structure comprising at least two electrode layers for detection of fluid content separated by at least one insulating layer. The multilayer structure defines at least one flow channel which provides a flow path for continuous flow of fluid in use, and the electrode layers form part of the sidewall of the flow channel(s). The flow channel(s) may run in a direction substantially perpendicular to the layers. The electrode layers may employ electrochemical detection and may comprise a reference electrode and an ion-sensitive electrode. The apparatus may be fabricated using various printing or deposition techniques.
    Type: Application
    Filed: July 5, 2013
    Publication date: January 9, 2014
    Inventors: Marcel Zevenbergen, Lindsay Brown, Maria Peter, Mercedes Crego Calama
  • Patent number: 8593287
    Abstract: Methods and systems for providing data communication in medical systems are disclosed.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: November 26, 2013
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Gary Hayter, Martin J. Fennell, Lei He, Mark K Sloan
  • Patent number: 8565850
    Abstract: The invention relates to sweat activity measurement, e.g. for determining a physiological state of a subject, embodied by a method as well as a kit with an immittance measuring circuit and electrodes with contact electrolyte. Sweat activity is considered a transport phenomenon and can be defined as a flux, e.g. gram water per skin area per second. Prior art methods determining water absorbed per gram dry stratum corneum measures skin moisture and do not truly reflect sweat activity. A periodic signal with frequency of 60 Hz or lower is applied to reduce contribution from complex admittance of the skin, and skin conductance is measured as a degree of sweat activity. The contact electrolyte allows filling of sweat ducts with sweat from sweat glands, this may be characterized in that it does not substantially fill the sweat ducts when being positioned on the skin and/or in that it has a re-absorption time constant from the sweat ducts into the Epidermis of less than 15 min.
    Type: Grant
    Filed: July 1, 2008
    Date of Patent: October 22, 2013
    Assignee: Universitetet i Oslo
    Inventors: Ørjan Grøttem Martinsen, Sverre Jøran Grimnes, Erik Fosse
  • Patent number: 8543182
    Abstract: Provided herein is a stabilized oxygen transport matrix that includes a reversible oxygen binding protein, such as hemoglobin, immobilized throughout the stabilized oxygen transport matrix. The stabilized oxygen transport matrix is used to transport oxygen and can be used as an oxygen transport region and a reaction region of an analyte sensor, such as an implantable glucose sensor. The reversible binding protein can also function as an oxygen probe within the analyte sensor.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: September 24, 2013
    Assignee: Metronom Health, Inc.
    Inventors: Elliot Botvinick, Troy M. Bremer
  • Publication number: 20130197319
    Abstract: The present invention includes a flexible sensor suitable for contact with skin comprising: a nanocomposite; and a top layer; where the sensor provides in-situ detection in sweat or other aqueous body fluids at the skin surface of at least one physiological parameter selected from the group consisting of a physiological salt component, temperature, moisture, humidity, or combinations thereof. The present invention further includes a method of fabricating a flexible sensor suitable for contact with skin comprising: electrospinning at least one polyamide-producing monomer to form a non-conductive polyamide substrate; attaching at least one plurality of conductive nanoscale attachments, wherein the nanoscale attachments are selected from nanotubes, nanoparticles, or combinations thereof, to form an intermediate layer; and functionalizing the intermediate layer to form a top layer.
    Type: Application
    Filed: January 28, 2013
    Publication date: August 1, 2013
    Applicant: THE UNIVERSITY OF AKRON
    Inventor: THE UNIVERSITY OF AKRON
  • Patent number: 8498685
    Abstract: A capacitive touch screen device forms a capacitance between a body part of a user and a sensor layer. The sensor layer of the device includes capacitive sensors that allow a current to flow to the body part from the device when contact is made. The body part contacts the device through a bodily fluid. The current drawn is measured and a value for the bodily fluid is determined. This value is compared against known values to diagnose a possible medical condition or to infer characteristics of the bodily fluid.
    Type: Grant
    Filed: January 14, 2011
    Date of Patent: July 30, 2013
    Assignee: Bionys, LLC.
    Inventor: Trishul Kapoor
  • Patent number: 8487772
    Abstract: A system and method for effectively communicating information using at least one mode of communication is described, in which information recipients proximate to a communications device within a pre-determined space and during a pre-determined time period are identified, from whom physiological state information is obtained that, when coupled with other characteristics information, is used to select from a plurality of information elements at least one information element to better target the information elements. The information element is then provided to the communications device so that it may be provided to the information recipients in the pre-determined space in a manner that is sensed by the information recipients.
    Type: Grant
    Filed: December 12, 2009
    Date of Patent: July 16, 2013
    Inventor: Brian William Higgins
  • Patent number: 8483792
    Abstract: Embodiments herein provide an analyte sensor subassembly that provides an integrated structure enabling suitably secure electrical contact between an analyte sensor and the electronic components of an analyte sensor assembly. An analyte sensor subassembly assists the process of inserting the sensor into skin. An analyte sensor subassembly may operate in concert with one or more sensor insertion tools to provide insertion of an analyte sensor into the skin of a subject/patient. Associated devices, such as channel guides and sensor insertion tools, are also provided, as are methods of operation and sensor insertion.
    Type: Grant
    Filed: March 17, 2009
    Date of Patent: July 9, 2013
    Assignee: iSense Corporation
    Inventors: Dennis Slomski, Robert Bruce, Jon Fortuna, David B. Kreitlow
  • Patent number: 8461985
    Abstract: Methods and systems for providing data communication in medical systems are disclosed.
    Type: Grant
    Filed: May 8, 2008
    Date of Patent: June 11, 2013
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Martin J. Fennell, Lei He, Mark K. Sloan
  • Publication number: 20130144131
    Abstract: Techniques and systems are disclosed for implementing textile-based screen-printed amperometric or potentiometric sensors. The chemical sensor can include carbon based electrodes to detect at least one of NADH, hydrogen peroxide, potassium ferrocyanide, TNT or DNT, in liquid or vapor phase. In one application, underwater presence of chemicals such as heavy metals and explosives is detected using the textile-based sensors.
    Type: Application
    Filed: May 18, 2011
    Publication date: June 6, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Joseph Wang, Joshua Ray Windmiller
  • Patent number: 8391946
    Abstract: In a measurement computation device arranged in a measurement device, an elapse of a predetermined time is detected after acceleration of perspiration, and a concentration of a first component in the perspiration obtained thereafter is converted to concentration of the first component in blood.
    Type: Grant
    Filed: May 7, 2010
    Date of Patent: March 5, 2013
    Assignee: Omron Healthcare Co., Ltd.
    Inventors: Junichi Sugenoya, Yuzo Nakase, Satoshi Nakajima, Muneo Tokita
  • Patent number: 8388534
    Abstract: An apparatus for providing skin care information, the apparatus including: an electrode unit supplying a voltage to a user's skin and detecting a current signal in the user's skin; a measurement control unit measuring the user's skin moisture content and sweat gland activity by using the detected current signal; a data calculation unit deriving skin moisture content information by using the skin moisture content and the sweat gland activity, and generating skin care information corresponding to the skin moisture content information; and an information provider providing the user with the generated skin care information is provided.
    Type: Grant
    Filed: September 24, 2007
    Date of Patent: March 5, 2013
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Woo Young Jang, Kun Soo Shin, Hong Sig Kim
  • Patent number: 8364228
    Abstract: A system and method for transdermal sampling wherein at least one pair of sample electrodes is adapted to provide voltage pulses capable of creating capillary openings in a subject's stratum corneum. Methods for using a transdermal sampling system by creating capillary openings in a subject's stratum corneum via the application of a series of voltage pulses to the stratum corneum and contacting at least a portion of at least one of the sample electrodes with interstitial fluid from the capillary openings are also presented.
    Type: Grant
    Filed: December 9, 2005
    Date of Patent: January 29, 2013
    Assignee: Flexible Medical Systems, LLC
    Inventors: John Frederick Currie, Makarand Paranjape
  • Publication number: 20120184833
    Abstract: A capacitive touch screen device forms a capacitance between a body part of a user and a sensor layer. The sensor layer of the device includes capacitive sensors that allow a current to flow to the body part from the device when contact is made. The body part contacts the device through a bodily fluid. The current drawn is measured and a value for the bodily fluid is determined. This value is compared against known values to diagnose a possible medical condition or to infer characteristics of the bodily fluid.
    Type: Application
    Filed: January 14, 2011
    Publication date: July 19, 2012
    Inventor: Trishul Kapoor
  • Patent number: 8043227
    Abstract: A non-invasive system and method for measuring skin hydration of a subject includes a thermistor used in transient mode to obtain a measurement of the thermal conductivity of the skin of the subject and a processor for determining a skin hydration value from the thermal conductivity measurement. The system for measuring skin hydration further includes a non-invasive system for detecting blood analyte concentration, such as glucose, with a spectroscopic device having e.g., an infrared source which generates infrared beam and detector for detecting transmitted radiation through portion (e.g., finger) of a subject. The system may also include skin hydrator which moisturizes the skin and is connected in a control loop to the system for measuring skin hydration. The system for detecting blood analyte concentration may include a photoacoustic device or a metabolic heat conformation device.
    Type: Grant
    Filed: December 26, 2006
    Date of Patent: October 25, 2011
    Assignee: Konklijke Philips Electronics N.V.
    Inventors: Antonius Theodorus Marinus Van Gogh, Maarten Marinus Johannes Wilhelm Van Herpen
  • Patent number: 7935064
    Abstract: Muscle cramps can be reduced or avoided by monitoring the concentration of salt in perspiration to indicate the degree of salt depletion. Based on the degree of salt depletion, a sufficient amount of rehydration beverage is consumed to normalize the salt level.
    Type: Grant
    Filed: July 31, 2008
    Date of Patent: May 3, 2011
    Assignee: Stokely-Van Camp, Inc.
    Inventors: Robert Murray, John R. Stofan, IV, Jeffrey J. Zachwieja, Craig A. Horswill, Myron C. Rapkin, Wayne W. Weber
  • Patent number: 7874995
    Abstract: Muscle cramps can be reduced or avoided by monitoring the concentration of salt in perspiration to indicate the degree of salt depletion. Based on the degree of salt depletion, a sufficient amount of rehydration beverage is consumed to normalize the salt level.
    Type: Grant
    Filed: November 1, 2006
    Date of Patent: January 25, 2011
    Assignee: Stokely-Van Camp, Inc.
    Inventors: Robert Murray, John R. Stofan, IV, Jeffrey J. Zachwieja, Craig A. Horswill, Myron C. Rapkin, Wayne W. Weber
  • Publication number: 20100179403
    Abstract: The invention relates to sweat activity measurement, e.g. for determining a physiological state of a subject, embodied by a method as well as a kit with an immittance measuring circuit and electrodes with contact electrolyte. Sweat activity is considered a transport phenomenon and can be defined as a flux, e.g. gram water per skin area per second. Prior art methods determining water absorbed per gram dry stratum corneum measures skin moisture and do not truly reflect sweat activity. A periodic signal with frequency of 60 Hz or lower is applied to reduce contribution from complex admittance of the skin, and skin conductance is measured as a degree of sweat activity. The contact electrolyte allows filling of sweat ducts with sweat from sweat glands, this may be characterized in that it does not substantially fill the sweat ducts when being positioned on the skin and/or in that it has a re-absorption time constant from the sweat ducts into the Epidermis of less than 15 min.
    Type: Application
    Filed: July 1, 2008
    Publication date: July 15, 2010
    Applicant: BIOGAUGE - NORDIC BIOIMPEDANCE RESEARCH AS
    Inventors: Orjan Grottem Martinsen, Sverre Joran Grimnes, Erik Fosse
  • Publication number: 20100130843
    Abstract: Wireless equipment for confirmatory diagnosis of cystic fibrosis through sweat testing, includes a module of analyzer/transmitter, with a box, built-in microprocessor for sweat induction analysis through chloride measurement device, radio antenna with a transmitter, battery, switch, and sensor card wiring connector with a single-use. The card has two iontophoresis electrodes, and ion-selective electrodes, built-in connector to the module, and a module terminal/receiver. The box (4) has a desktop keyboard, a LCD, microprocessor, USB connections for peripherals, radio antenna with receiver to get data “live” from the analyzer module/transmitter. The device is powered by batteries or wall electrical socket.
    Type: Application
    Filed: November 24, 2008
    Publication date: May 27, 2010
    Applicant: TECNICAS CIENTIFICAS PARA LABORATORIO, S.A
    Inventors: Alejandro Caceres Galvez, Rosa Passarell Serred
  • Patent number: 7725149
    Abstract: Described are devices, methods, and kits for non-invasively measuring glucose. In general, the devices comprise skin patches for placement on a skin surface and measurement devices for measuring glucose collected in the patches. The patches may include an adhesive material, a collection layer, an interface layer, and a sweat-permeable membrane. The sweat-permeable membrane is configured to act as a barrier to epidermal contaminants and glucose brought to the skin surface via diffusion. In this way, non-correlatable skin surface glucose will not be measured. The patches may further include components to induce a local sweat response. The measurement device typically includes a display, a processor, and a measurement mechanism. The methods typically include the steps of wiping the skin surface with a wipe containing at least one solvent for removing glucose, placing a patch on a skin surface, and measuring glucose collected in the patch. Kits comprising the patch and measurement device are also described.
    Type: Grant
    Filed: June 22, 2005
    Date of Patent: May 25, 2010
    Inventors: Thomas A. Peyser, Russell O. Potts, Herbert L. Berman, James W. Moyer, Mikhail A. Kouchnir
  • Publication number: 20100063372
    Abstract: Devices, methods, and kits for collecting sweat that has come to the surface of the skin are provided. The sweat may be collected for measuring sweat glucose levels. Because sweat glucose levels correlate to blood glucose levels, the provided devices, methods, and kits may be used by diabetic patients to non-invasively monitor blood glucose levels. Sweat collection devices may be attachable to the surface of the skin and may collect about one microliter or less of sweat. Because only a small, fixed volume of sweat may be collected, the sweat glucose level may be measured in a matter of minutes. Further, as a fixed volume of sweat is tested, inaccuracies due to estimates of the sweat volume being tested are less likely to cause an inaccurate glucose measurement.
    Type: Application
    Filed: September 8, 2009
    Publication date: March 11, 2010
    Inventors: Russell O. POTTS, James W. Moyer, Hiroshi Yanazawa, Irina Finkelshtein, Shuying Ye
  • Publication number: 20090270704
    Abstract: Described here are patches, systems, and methods for measuring glucose. In general, the patches comprise a microfluidic collection layer and a detector, and the systems comprise a patch and a measurement device. Some methods for measuring glucose comprise cleaning the skin surface, collecting sweat from the skin surface using a microfluidic collection device, and measuring the collected glucose. Other methods comprise cleaning the skin surface, collecting sweat in a patch comprising a microfludic collection layer, and measuring glucose collected in the patch. Still other methods comprise cleaning the skin surface, collecting a first sweat sample from the skin surface in a patch comprising a microfludic collection layer and a detector layer, transferring the first sweat sample from the collection layer to the detector layer, measuring glucose in the first sweat sample, and repeating the collection, transferring, and measuring steps at least once.
    Type: Application
    Filed: May 4, 2009
    Publication date: October 29, 2009
    Inventors: Thomas A. PEYSER, Russell O. Potts, Herbert L. Berman, James W. Moyer, Mikhail A. Kouchnir, Robert N. Blair
  • Patent number: 7438691
    Abstract: A method and device to predict ovulation in a female human by measuring changes in the concentration of a number of ions in eccrine sweat is disclosed. The concentration, or changes in concentration, of one or more ions are determined throughout the day and analyzed against predetermined patterns in order to predict ovulation one to five days in advance. This permits the user to more accurately determine commencement of the fertile phase, which for female humans is generally considered to be about four days prior to ovulation to one day after ovulation. The concentration of the ions measured include sodium (Na+), potassium (K+), ammonium (NH4+), calcium (Ca2+), chloride (Cl?) and nitrate (NO3?). To further increase the accuracy of the reading, a large number of readings can be obtained throughout a day and statistically analyzed to determine the change over time. In addition, the concentration of two or more ions can be obtained to increase accuracy.
    Type: Grant
    Filed: July 29, 2002
    Date of Patent: October 21, 2008
    Assignee: HealthWatchSystems, Inc.
    Inventor: Douglas M. Marett
  • Patent number: 7383072
    Abstract: A method of sensing the concentration level of at least one particular electrolyte in the sweat fluid of a subject, includes providing a sweat sensor system having sweat fluid absorbing material, measuring apparatus for sensing the electrical conductivity of sweat fluid absorbed by the absorbing material and producing ionic concentration data for said at least one particular electrolyte, and a user interface connected to the measurement apparatus for interpreting the data to a user. The absorbing material is applied to the skin of the subject to cause sweat fluid thereon to be absorbed by the absorbing material whereby the measurement apparatus produces ionic concentration data for the sweat fluid absorbed and the user interface interprets the data for a user.
    Type: Grant
    Filed: May 9, 2005
    Date of Patent: June 3, 2008
    Assignee: P. J. Edmonson Ltd
    Inventors: Peter J. Edmonson, Douglas W. Stoddard
  • Publication number: 20080091091
    Abstract: An apparatus for providing skin care information, the apparatus including: an electrode unit supplying a voltage to a user's skin and detecting a current signal in the user's skin; a measurement control unit measuring the user's skin moisture content and sweat gland activity by using the detected current signal; a data calculation unit deriving skin moisture content information by using the skin moisture content and the sweat gland activity, and generating skin care information corresponding to the skin moisture content information; and an information provider providing the user with the generated skin care information is provided.
    Type: Application
    Filed: September 24, 2007
    Publication date: April 17, 2008
    Inventors: Woo Young JANG, Kun Soo SHIN, Hong Sig KIM
  • Publication number: 20030199743
    Abstract: Marker compounds indicative of variations in physiological conditions, genetic defects or disease states have been found to be present in apocrine sweat and, in many conditions, these markers are present in apocrine sweat in elevated levels when compared to blood. These markers are collected and/or detected in apocrine sweat and used as an indicator that a disease state or particular physiological condition exists. A skin patch, wipe or other collection means is used to collect apocrine sweat. The apocrine sweat is then used to indicate the existence of a disease state or changing physiological condition by the presence of specific marker compounds.
    Type: Application
    Filed: June 16, 2003
    Publication date: October 23, 2003
    Inventor: Stuart M. Berlin
  • Patent number: 6623427
    Abstract: A personal entertainment system calibrated and controlled by the biological or physiological condition of a user is disclosed. The entertainment system includes a media player; a sensor operative to detect biological parameters and generating a control signal in response to the detected parameters, the sensor being operably coupled to the media player; and a processing element which associates the control signal to at least one type of media preference, and causes the media player to provide media stimuli based on the control signal. Thus the media stimuli provided by the entertainment system is specific to the individual preferences and detected condition of the user.
    Type: Grant
    Filed: September 25, 2001
    Date of Patent: September 23, 2003
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventor: Lonnie D Mandigo
  • Patent number: 6589171
    Abstract: Apparatus for temporarily attaching a sensor of a physiological parameter to an extremity of a person. The apparatus includes a fabric structure configured to be positioned on an extremity of a person, the fabric structure advantageously formed of loops of yarn-like material which exhibit porosity and controlled elasticity; and sensor(s) of physiological parameters mounted on the fabric structure such that when the structure is positioned on the extremity of a person, the sensors sense physiological parameters of the person.
    Type: Grant
    Filed: June 27, 2001
    Date of Patent: July 8, 2003
    Assignee: Eastman Kodak Company
    Inventor: Richard S. Keirsbilck
  • Patent number: 6501002
    Abstract: Disclosed is a disposable surface wipe having a sensor which detects bodily waste contamination on a surface and which provides a signal indicating the presence of such contamination, desirably by detecting a component of the waste normally present in waste excreted by healthy individuals and not a component infrequently present in the waste due to special circumstances related to the health or other transient condition of the excreter. The signal provided by the sensor can be visible to a user of the article, and the article can include a substrate which incorporates the sensor. In a preferred embodiment, the article is a cleaning article which can efficaciously clean bodily waste contamination from a surface.
    Type: Grant
    Filed: January 26, 2000
    Date of Patent: December 31, 2002
    Assignee: The Proctor & Gamble Company
    Inventors: Donald C. Roe, Anupama R. Mirle
  • Patent number: 6479015
    Abstract: An apparatus for monitoring a level of a chemical species in a body fluid includes a fluid collection layer adapted for receiving the body fluid. The fluid collection layer is dry prior to being brought into contact with the body fluid. A catalyst is provided in, on, or near the fluid collection layer so as to be in contact with the body fluid in the fluid collection layer. The catalyst facilitates a reaction of the chemical species in the body fluid. An indicator, responsive to the reaction of the chemical species, is also provided in, on, or near the fluid collection layer. A characteristic of the indicator changes in response to the reaction of the chemical species, thereby indicating the level of the chemical species in the body fluid. This apparatus can be used, for example, to monitor the level of lactate in perspiration during activities, such as exercise or other athletic exertions.
    Type: Grant
    Filed: March 3, 1998
    Date of Patent: November 12, 2002
    Assignee: Pepex Biomedical, LLC
    Inventors: Nathan R. Long, Eric A. Peper, James L. Say, Mark S. Vreeke
  • Patent number: 6443892
    Abstract: The invention is useful for providing sweat collecting devices for the detection of chemicals or biochemicals in the perspiration of a living subject while reducing drug contamination from without (external sources), and for detecting tampering of the sweat collection device. The invention also provides a method for using the sweat collecting device which reduces and identifies prior chemical or biochemical contamination on the skin of the tested subject.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: September 3, 2002
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventor: David A. Kidwell
  • Publication number: 20020091312
    Abstract: Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. One important application of the invention involves a method and device for monitoring blood glucose values.
    Type: Application
    Filed: December 20, 2001
    Publication date: July 11, 2002
    Applicant: Cygnus, Inc.
    Inventors: Bret Berner, Chia-Ming Chiang, Michael D. Garrison, Janan Jona, Russell O. Potts, Janet A. Tamada, Michael J. Tierney
  • Patent number: 6356775
    Abstract: A biological data observation system makes it possible to accurately observing the anesthetic depth of a patient. The system measures a signal based on the pulse wave of the patient, and measures the sweat rate. During a surgery, these data and/or their composite data is monitored. The system displays transition of the sweat rate. Therefore, if during the surgery the patient's condition changes, an operating doctor (operator) will immediately notice a change in the sweat rate displayed by the system, so that the doctor or the like can promptly take an appropriate measure for the change in the patient's condition. By observing the transition of the patient's blood pressure displayed by the system, the doctor can also understand how the patient's condition changes as a result of the doctor's measure.
    Type: Grant
    Filed: April 17, 2000
    Date of Patent: March 12, 2002
    Assignees: Kyoho Machine Works. Ltd., Kabushiki Gaisya K-and S
    Inventors: Shinji Kondo, Hirohide Urano
  • Patent number: 6284126
    Abstract: An electrode assembly for sensing an electrochemical signal diffused from a source to a working electrode which is comprised of a plurality of substantially separated working electrode surfaces is disclosed. The electrode of the invention is comprised of 1) a working electrode made up of a plurality of working electrode surfaces or components and 2) a electrically insulating gap defined by adjacent edges of 1) insulating the working electrode surfaces or components from each other. The working electrode components are configured to receive electrochemical signal from two or preferably three dimensions simultaneously. The working electrode components configured over the same surface as a single electrode provide (1) an improved signal to noise ratio as compared to a single electrode by reducing noise, and (2) provide an overall enhanced signal after sensing for a given period of time.
    Type: Grant
    Filed: August 28, 2000
    Date of Patent: September 4, 2001
    Assignee: Cygnus, Inc.
    Inventors: Ronald T. Kurnik, Janet Tamada, Michael Tierney
  • Publication number: 20010016682
    Abstract: A method is provided for continually or continuously measuring the concentration of target chemical analytes present in a biological system, and processing analyte-specific signals to obtain a measurement value that is closely correlated with the concentration of the target chemical analyte in the biological system. One important application of the invention involves a method for signal processing in a system for monitoring blood glucose values.
    Type: Application
    Filed: February 27, 2001
    Publication date: August 23, 2001
    Applicant: Cygnus, Inc.
    Inventors: Bret Berner, Timothy C. Dunn, Kathleen C. Farinas, Michael D. Garrison, Ronald T. Kurnik, Matthew J. Lesho, Russell O. Potts, Janet A. Tamada, Michael J. Tierney
  • Patent number: 6269261
    Abstract: The invention aims to provide a health care instrument adapted to measure oxidation-reduction potential in human being, animal, fish and shellfish, plant, vegetable as well as water, air or earth surrounding those organisms and thereby to determine a level of active oxygen in such subject so that the measured data may be used for health care. The object set forth above is achieved by a health care instrument containing an oxidation-reduction potential measuring function comprising a main body, a power source consisting of a battery with or without a battery charger and an oxidation-reduction potential measuring unit both contained in the main body, a measuring probe attached to one end of the main body, a sensor included in the measure probe so as to be connected to the oxidation-reduction potential measuring unit, and a display unit provided on a part of the main body to display the measured oxidation-reduction potential value.
    Type: Grant
    Filed: October 24, 1997
    Date of Patent: July 31, 2001
    Assignee: Yugen Kaisha Endo Process
    Inventor: Yoshitaka Ootomo
  • Patent number: 6233471
    Abstract: A method is provided for continually or continuously measuring the concentration of target chemical analytes present in a biological system, and processing analyte-specific signals to obtain a measurement value that is closely correlated with the concentration of the target chemical analyte in the biological system. One important application of the invention involves a method for signal processing in a system for monitoring blood glucose values.
    Type: Grant
    Filed: May 11, 1999
    Date of Patent: May 15, 2001
    Assignee: Cygnus, Inc.
    Inventors: Bret Berner, Timothy C. Dunn, Kathleen C. Farinas, Michael D. Garrison, Ronald T. Kurnik, Matthew J. Lesho, Russell O. Potts, Janet A. Tamada, Michael J. Tierney
  • Patent number: 6144869
    Abstract: Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. One important application of the invention involves a method and device for monitoring blood glucose values.
    Type: Grant
    Filed: May 11, 1999
    Date of Patent: November 7, 2000
    Assignee: Cygnus, Inc.
    Inventors: Bret Berner, Chia-Ming Chiang, Michael D. Garrison, Janan Jona, Russell O. Potts, Janet A. Tamada, Michael J. Tierney
  • Patent number: 6129665
    Abstract: An electro-medical apparatus for receiving bio-electrical signals from a human body. At least 17 electrodes are applied to specific areas of the body of the patient. The signals received therein are automatically processed by a personal computer which analyzes the health state of the patient by way of specific software. An expert system can additionally be included which includes control software, analysis software and interpretation software to provide the physician with first indication data about the health of the patient and with possible modes of intervention, so that the physician can arrive at a substantially definitive interpretation of the health state of the patient.
    Type: Grant
    Filed: November 27, 1998
    Date of Patent: October 10, 2000
    Assignee: Biotekna S.r.l
    Inventor: Simone Zanin
  • Patent number: RE38681
    Abstract: An electrode assembly for sensing an electrochemical signal diffused from a source to a working electrode which is comprised of a plurality of substantially separated working electrode surfaces is disclosed. The electrode of the invention is comprised of 1) a working electrode made up of a plurality of working electrode surfaces or components and 2) a electrically insulating gap defined by adjacent edges of 1) insulating the working electrode surfaces or components from each other. The working electrode components are configured to receive electrochemical signal from two or preferably three dimensions simultaneously. The working electrode components configured over the same surface as a single electrode provide (1) an improved signal to noise ratio as compared to a single electrode by reducing noise, and (2) provide an overall enhanced signal after sensing for a given period of time.
    Type: Grant
    Filed: December 2, 2002
    Date of Patent: January 4, 2005
    Assignee: Cygnus, Inc.
    Inventors: Ronald T. Kurnik, Janet Tamada, Michael J. Tierney
  • Patent number: RE40470
    Abstract: Body function measuring apparatus which provides: (1) an indication of the body function being measured, and (2) a loose probe condition by determining that the difference between the rate of change of a first body function signal, developed by a first sensor in the probe, and the rate of change of a second body function signal, developed by a second sensor in the probe, exceeds a predetermined threshold.
    Type: Grant
    Filed: March 30, 2000
    Date of Patent: August 26, 2008
    Assignee: Draeger Medical Systems, Inc.
    Inventors: Joseph F. Fitzpatrick, Anthony C. Romano, John H. Richards, Ronald S. Kolarovic