Electroanalysis Patents (Class 600/345)
  • Patent number: 12082928
    Abstract: An inventive medical system has a housing with a first guiding surface. A preassembled module is received in the housing. The module includes electronics electrically connected to an analytical sensor, an insertion component configured for inserting the analytical sensor into body tissue of a user and a sterility cap at least partially surrounding the insertion component. The module has a second guiding surface. A protective cap is removably connected to the housing and covers the preassembled module. The protective cap is removable from the housing by pulling the protective cap from the housing. The first guiding surface guides the protective cap during the pulling of the protective cap from the housing and the second guiding surface guides the sterility cap during pulling the sterility cap from the insertion component. The length of the first guiding surface exceeds the length of the second guiding surface.
    Type: Grant
    Filed: August 4, 2023
    Date of Patent: September 10, 2024
    Assignee: Roche Diabetes Care, Inc.
    Inventor: Ahmet Konya
  • Patent number: 12082788
    Abstract: An instrument and method for collecting and harvesting gingival crevicular fluid samples in a noninvasive manner is provided. Once optimally positioned, an absorbing brush of the instrument is inserted into the gingival sulcus of a patient and held in place while the bristles of the absorbing brush absorb the gingival crevicular fluid. Once removed from the collection sight, the absorbing brush bristles can provide a visual indication of the presence of biomarkers and proteins associated with periodontitis.
    Type: Grant
    Filed: August 3, 2023
    Date of Patent: September 10, 2024
    Assignee: KING FAISAL UNIVERSITY
    Inventors: Zohaib Khurshid, Syed Akhtar Bokhari, Muhammad Sohail Zafar, Syed Faraz Moin, Shariq Najeeb
  • Patent number: 12064244
    Abstract: An inventive medical system has a housing with a first guiding surface. A preassembled module is received in the housing. The module includes electronics electrically connected to an analytical sensor, an insertion component configured for inserting the analytical sensor into body tissue of a user and a sterility cap at least partially surrounding the insertion component. The module has a second guiding surface. A protective cap is removably connected to the housing and covers the preassembled module. The protective cap is removable from the housing by pulling the protective cap from the housing. The first guiding surface guides the protective cap during the pulling of the protective cap from the housing and the second guiding surface guides the sterility cap during pulling the sterility cap from the insertion component. The length of the first guiding surface exceeds the length of the second guiding surface.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: August 20, 2024
    Assignee: Roche Diabetes Care, Inc.
    Inventor: Ahmet Konya
  • Patent number: 12064245
    Abstract: An inventive medical system has a housing with a first guiding surface. A preassembled module is received in the housing. The module includes electronics electrically connected to an analytical sensor, an insertion component configured for inserting the analytical sensor into body tissue of a user and a sterility cap at least partially surrounding the insertion component. The module has a second guiding surface. A protective cap is removably connected to the housing and covers the preassembled module. The protective cap is removable from the housing by pulling the protective cap from the housing. The first guiding surface guides the protective cap during the pulling of the protective cap from the housing and the second guiding surface guides the sterility cap during pulling the sterility cap from the insertion component. The length of the first guiding surface exceeds the length of the second guiding surface.
    Type: Grant
    Filed: August 4, 2023
    Date of Patent: August 20, 2024
    Assignee: Roche Diabetes Care, Inc.
    Inventor: Ahmet Konya
  • Patent number: 12059535
    Abstract: A method for calibrating a medical device is provided. The method implemented by a calibration engine executed by one or more processors. The method includes capturing one or more voltage measurements by one or more components of a catheter, estimating calibration data based on the one or more voltage measurements, and outputting the calibration data to the catheter.
    Type: Grant
    Filed: January 28, 2021
    Date of Patent: August 13, 2024
    Assignee: BIOSENSE WEBSTER (ISRAEL) LTD.
    Inventors: Daniel Osadchy, Meir Bar-Tal, Avram Dan Montag
  • Patent number: 12057244
    Abstract: One aspect relates to a process for preparing a processed filament, including provision of a filament, including a segment. At least in the segment, the filament includes a core, including a first metal, a first layer which is superimposed on the core, and includes a polymer, and a second layer which is superimposed on the first layer, and includes a second metal. The segment of the filament is processed by interaction of the segment with at least one beam of electromagnetic radiation of a first kind. The electromagnetic radiation of the first kind has a spectrum with a peak wavelength in the range from 430 to 780 nm. Further, one aspect relates to a processed filament, obtainable by the process; a filament; an electrical device, including at least a part of the processed filament.
    Type: Grant
    Filed: July 15, 2020
    Date of Patent: August 6, 2024
    Assignees: Heraeus Medical Components LLC, Heraeus Deutschland GmbH & Co. KG
    Inventors: Jörg-Martin Gebert, Paul Schuster, Lisa Meyer
  • Patent number: 12052067
    Abstract: Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are disclosed. In an embodiment, a method for transmitting data between a first communication device associated with an analyte sensor and a second communication device configured to provide user access to sensor-related information comprises: activating a transceiver of a first communication device associated with an analyte sensor at a first time; and establishing a two-way communication channel with the second communication device; wherein the activating comprises waking the transceiver from a low power sleep mode using a forced wakeup from the second communication device.
    Type: Grant
    Filed: August 23, 2023
    Date of Patent: July 30, 2024
    Inventors: Thomas Miller, Mark Dervaes, Phong Lieu, Peter C. Simpson, Shawn Larvenz, Jacob S. Leach, Sebastian Bohm
  • Patent number: 11992650
    Abstract: A system is disclosed. The system includes a reservoir for receiving an infusion medium from an infusion medium container, the reservoir includes a collapsible housing having an interior volume for holding the infusion medium, the collapsible housing being collapsible from an expanded state to reduce the interior volume and being expandable from a collapsed state to increase the interior volume, a first port including a septum, and a second port fluidly connected to a pumping assembly.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: May 28, 2024
    Assignee: DEKA Products Limited Partnership
    Inventors: Dean Kamen, Larry B. Gray, Eric Yeaton
  • Patent number: 11977311
    Abstract: A viewing angle adjusting member and an electronic device including the same are provided. The viewing angle adjusting member includes a first transparent film including a first transparent electrode layer, a second transparent film including a second transparent electrode layer, and a blocking material provided between the first transparent film and the second transparent film and containing nanoparticles configured to block light. The viewing angle adjusting member may be configured to adjust a position of the nanoparticles according to an electrical signal applied to at least one of the first transparent electrode layer and the second transparent electrode layer.
    Type: Grant
    Filed: December 10, 2021
    Date of Patent: May 7, 2024
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Taesoon Park, Junyoung Kim, Kwansik Min, Sanghee Park
  • Patent number: 11959872
    Abstract: The present invention provides a method for accurately measuring a blood component despite uneven distribution of blood introduced into a capillary. The measurement method according to the present invention is characterized in that a plurality of electrode systems for measuring the hematocrit are provided in a capillary of a biosensor to measure the hematocrit at different positions in the capillary. By measuring the hematocrit at the plurality of positions in the capillary as described above, the hematocrit can be measured mom accurately despite uneven distribution of blood introduced into the capillary.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: April 16, 2024
    Assignee: PHC Holdings Corporation
    Inventors: Masaki Fujiwara, Yoshifumi Takahara, Takaaki Fujii, Setsuko Yano, Fuminori Kutsuna
  • Patent number: 11957488
    Abstract: A medical device includes a sensor to observe a characteristic of an anatomy, and a sensor base coupled to the sensor. The medical device includes a coupling system to couple the sensor base to the anatomy. The coupling system includes a first adhesive member and a second adhesive member. The first adhesive member is coupled to the sensor base and the second adhesive member is to couple to the anatomy. The first adhesive member includes at least one cut-out to direct moisture to an ambient environment surrounding the medical device.
    Type: Grant
    Filed: February 7, 2020
    Date of Patent: April 16, 2024
    Assignee: Medtronic Minimed, Inc.
    Inventors: Jasson Rodriguez, Ellis Garai, Ravi R. Deverkadra, Sara M. Voisin, Jacob E. Pananen
  • Patent number: 11925772
    Abstract: A powered catheter and/or powered catheter system is described. The catheter includes a catheter hub with one set of contact components that are configured to connect to a mating cable with a corresponding second set of contact components. The mating cable can be part of another device, such as a controller or power source.
    Type: Grant
    Filed: June 15, 2021
    Date of Patent: March 12, 2024
    Assignee: MicroVention, Inc.
    Inventors: Parker Milhous, Heath Bowman, Kaushik Joshi
  • Patent number: 11872039
    Abstract: Method and system for providing continuous calibration of analyte sensors includes calibrating a first sensor, receiving data associated with detected analyte levels from the first sensor, and calibrating a second sensor based on a predetermined scaling factor and data associated with detected analyte levels from the first sensor, is disclosed.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: January 16, 2024
    Assignee: ABBOTT DIABETES CARE INC.
    Inventor: Benjamin Jay Feldman
  • Patent number: 11874285
    Abstract: A method of calibrating a device for measuring the concentration of creatinine using one or more calibration solutions, the method comprising: receiving concentrations at an initial time of creatine, Cr, and/or creatinine, Crn, of the one or more calibration solutions; receiving outputs of the measuring device at the end time; calculating the concentration of Cr and/or Crn in the calibration solutions at an end time using a temperature model, wherein the temperature model indicates an estimation of the temperature of the calibration solutions from the initial time to the end time, and wherein the temperature model includes a variable parameter; and determining a relationship between the outputs of the measuring device and the calculated concentrations of Cr and/or Crn.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: January 16, 2024
    Assignee: Radiometer Medical ApS
    Inventors: Thomas Kjaer, Thomas Pedersen Nyggard
  • Patent number: 11850045
    Abstract: An analyte sensor system is provided. The system includes a base configured to attach to a skin of a host. The base includes an analyte sensor configured to generate a sensor signal indicative of an analyte concentration level of the host, a battery, and a first plurality of contacts. The system includes a sensor electronics module configured to releasably couple to the base. The sensor electronics module includes a second plurality of contacts, each configured to make electrical contact with a respective one of the first plurality of contacts, and a wireless transceiver configured to transmit a wireless signal based at least in part on the sensor signal. The system includes a first sealing member configured to provide a seal around the first and second plurality of contacts within a first cavity. Related analyte sensor systems, analyte sensor base assemblies and methods are also provided.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: December 26, 2023
    Assignee: DexCom, Inc.
    Inventors: Neel Narayan Shah, Neal Davis Johnston, Matthew Bettman, Eric Gobrecht, Ryan Marc Braunstein
  • Patent number: 11806124
    Abstract: A signal measuring apparatus and method is provided. The signal measuring apparatus inputs a reduced voltage signal to an input end of an amplifier by resetting a voltage signal, which is acquired by applying a known current signal to a target object, using a common mode voltage at least once during one period of a current signal. The signal measuring apparatus acquires a digital signal corresponding to an object impedance change by converting an output of the amplifier.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: November 7, 2023
    Assignee: Samsung Electronics Co., Ltd.
    Inventor: JongPal Kim
  • Patent number: 11690537
    Abstract: An analyte sensor system is provided. The system includes a base configured to attach to a skin of a host. The base includes an analyte sensor configured to generate a sensor signal indicative of an analyte concentration level of the host, a battery, and a first plurality of contacts. The system includes a sensor electronics module configured to releasably couple to the base. The sensor electronics module includes a second plurality of contacts, each configured to make electrical contact with a respective one of the first plurality of contacts, and a wireless transceiver configured to transmit a wireless signal based at least in part on the sensor signal. The system includes a first sealing member configured to provide a seal around the first and second plurality of contacts within a first cavity. Related analyte sensor systems, analyte sensor base assemblies and methods are also provided.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: July 4, 2023
    Assignee: DexCom, Inc.
    Inventors: Neel Narayan Shah, John Michael Gray, Jason Halac, Carl Erich Hoffmeier, Neal Davis Johnston, Nicholas Kalfas
  • Patent number: 11674949
    Abstract: Method and system for self-assessment of drinking behavior. According to one embodiment, the method includes examining a transdermal alcohol response curve obtained from a drinking event, querying a user on their feelings of intoxication after or during the event, and using the combination of the objective measurement and subjective feelings of intoxication to provide an alert or status during subsequent drinking events. In so doing, the method mitigates at least some of the drawbacks associated with conventional alcohol monitoring devices by correlating an individual's reported feelings of intoxication with an objective transdermal measurement of alcohol.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: June 13, 2023
    Assignee: IA SMART START LLC
    Inventor: Michael Moeller
  • Patent number: 11677254
    Abstract: A battery-operated electronic device, such as, e.g., a continuous glucose monitoring (CGM) transmitter, has a switch disconnect circuit that reduces battery discharge while the device is stored and/or in “shelf mode.” The device has two externally-accessible activation pads each configured to contact a same electrical conductor positioned in packaging for the device that causes the switch disconnect circuit to disconnect the battery from device electronics while the device is in the packaging. Upon removal of the device from the packaging, the two activation pads no longer contact the electrical conductor, causing the switch disconnect circuit to automatically connect the battery to the device electronics. Methods of reducing battery discharge in a battery-operated electronic device and other aspects are also described.
    Type: Grant
    Filed: September 17, 2020
    Date of Patent: June 13, 2023
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventor: Igor Y. Gofman
  • Patent number: 11668709
    Abstract: The present disclosure relates to a system for monitoring post-translational modification of protein using a biosensor with a gap, which performs with high reliability a diagnosis of a disease associated with a target protein for which impedance is measured, by measuring an impedance of a sample introduced into a sensor and calculating a change rate of the measured impedance, and to a method of manufacturing the biosensor used for the system.
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: June 6, 2023
    Assignee: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Soo Hyun Lee, Ji Yoon Kang, Hyewhon Rhim, Yi Jae Lee, Hyewon Seo, Yun Kyung Kim
  • Patent number: 11653840
    Abstract: A method for monitoring autoregulation includes, using a processor, using a processor to execute one or more routines on a memory. The one or more routines include receiving one or more physiological signals from a patient, determining a correlation-based measure indicative of the patient's autoregulation based on the one or more physiological signals, and generating an autoregulation profile of the patient based on autoregulation index values of the correlation-based measure. The autoregulation profile includes the autoregulation index values sorted into bins corresponding to different blood pressure ranges. The one or more routines also include designating a blood pressure range encompassing one or more of the bins as a blood pressure safe zone indicative of intact regulation and providing a signal to a display to display the autoregulation profile and a first indicator of the blood pressure safe zone.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: May 23, 2023
    Assignee: COVIDIEN LP
    Inventors: Paul Stanley Addison, James N. Watson, Dean Montgomery
  • Patent number: 11642048
    Abstract: An analyte sensor system is provided. The system includes a base configured to attach to a skin of a host. The base includes an analyte sensor configured to generate a sensor signal indicative of an analyte concentration level of the host, a battery, and a first plurality of contacts. The system includes a sensor electronics module configured to releasably couple to the base. The sensor electronics module includes a second plurality of contacts, each configured to make electrical contact with a respective one of the first plurality of contacts, and a wireless transceiver configured to transmit a wireless signal based at least in part on the sensor signal. The system includes a first sealing member configured to provide a seal around the first and second plurality of contacts within a first cavity. Related analyte sensor systems, analyte sensor base assemblies and methods are also provided.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: May 9, 2023
    Assignee: DexCom, Inc.
    Inventors: Neel Narayan Shah, John Michael Gray, Jason Halac, Carl Erich Hoffmeier, Neal Davis Johnston, Nicholas Kalfas
  • Patent number: 11638540
    Abstract: Various analyte sensor systems for controlling activation of analyte sensor electronics circuitry are provided. Related methods for controlling analyte sensor electronics circuitry are also provided. Various analyte sensor systems for monitoring an analyte in a host are also provided. Various circuits for controlling activation of an analyte sensor system are also provided. Analyte sensor systems utilizing a state machine having a plurality of states for collecting a plurality of digital counts and waking a controller responsive to a wake up signal are also provided. Related methods for such analyte sensor systems are also provided. Systems for controlling activation of analyte sensor electronics circuitry utilizing a magnetic sensor are further provided. One or more display device configured to display one or more analyte concentration values are also provided.
    Type: Grant
    Filed: May 1, 2019
    Date of Patent: May 2, 2023
    Assignee: Dexcom, Inc.
    Inventors: Jason Halac, Sebastian Bohm, Vincent Peter Crabtree, David DeRenzy, Mark S. Dervaes, Nicholas Kalfas, Zebediah L. McDaniel, Michael Levozier Moore, Todd Andrew Newhouse, Michael A. Ploof, Stephen Alan Reichert, Peter C. Simpson, Alexander Leroy Teeter, Rodolfo Garcia, Jaroslaw Piotrowiak, Thomas George O'Connell, Arlene G. Doria
  • Patent number: 11589791
    Abstract: A measuring apparatus is configured to be connected to an electrode to measure biopotential. The measuring apparatus has an input box to which the electrode is connected. The input box has a tubular elastic member configured to hold a cap to be mounted on the electrode, and an insertion portion configured such that the elastic member is insertable into the insertion portion. The elastic member has an entrance having a first inner diameter and a contracted portion having a second inner diameter smaller than the first inner diameter.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: February 28, 2023
    Assignee: NIHON KOHDEN CORPORATION
    Inventors: Shogo Shirasaka, Norihide Shimizu, Takanori Sato
  • Patent number: 11589788
    Abstract: The present invention relates to a method to predict the risk of obtaining a stress related mood disorder or syndrome by a person, comprising a. Measuring at least three parameters comprising at least one sympathetic, one parasympathetic and one hormonal parameter during a stress response, said result of the measurement depicted as RS, RP and RH respectively; b. Estimate the value of one of these parameters by calculating it from the other two parameters; c. Predict the risk on basis of the deviation between calculated and measured value of the parameter that has been estimated in step b).
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: February 28, 2023
    Assignee: NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO
    Inventor: Victor Louis Kallen
  • Patent number: 11585734
    Abstract: An analytical toilet comprising a bowl for receiving excreta from a user; a base supporting the bowl; a supply of flush water; and a plurality of receptacles, each providing mechanical attachment, a power supply, and a data connection to an analytical device, which analytical device is adapted to provide data useful to the user is disclosed.
    Type: Grant
    Filed: March 6, 2020
    Date of Patent: February 21, 2023
    Assignee: Medic, Inc.
    Inventors: David R. Hall, David Crismon, Joshua Larsen, Jared Reynolds, Kevin Jeffrey Campbell
  • Patent number: 11559260
    Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for processing sensor data, including calculating a rate of change of sensor data and/or determining an acceptability of sensor or reference data.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: January 24, 2023
    Assignee: Dexcom, Inc.
    Inventors: Apurv Ullas Kamath, Ying Li
  • Patent number: 11517229
    Abstract: A biosensing device includes a sensor module and an electric signal transducer. The sensor module includes a biosensor adapted for measuring a biosignal of a host, and a fixed seat including a conducting member that is electrically connected to the biosensor. The electric signal transducer is for receiving and sending the biosignal measured by the biosensor, is coupled to the sensor module, and includes an electric signal unit electrically connected to the conducting member, and a battery connected to the electric signal unit. The electric signal unit has two electrical contacts that cooperatively define a switch. The battery provides power supply to the biosensor when the electric signal transducer is coupled to the sensor module.
    Type: Grant
    Filed: May 27, 2020
    Date of Patent: December 6, 2022
    Assignee: BIONIME CORPORATION
    Inventors: Chun-Mu Huang, Chieh-Hsing Chen
  • Patent number: 11478194
    Abstract: Described herein are variations of an analyte monitoring system, including an analyte monitoring device. For example, an analyte monitoring device may include an implantable microneedle array for use in measuring one or more analytes (e.g., glucose), such as in a continuous manner. The microneedle array may include, for example, at least one microneedle including a tapered distal portion having an insulated distal apex, and an electrode on a surface of the tapered distal portion located proximal to the insulated distal apex. At least some of the microneedles may be electrically isolated such that one or more electrodes is individually addressable.
    Type: Grant
    Filed: July 29, 2021
    Date of Patent: October 25, 2022
    Assignee: Biolinq Incorporated
    Inventors: Joshua Ray Windmiller, Jared Rylan Tangney, Buddhadev Paul Chaudhuri, Richard Chien Yang
  • Patent number: 11471275
    Abstract: Sensor-integrated prosthetic valves that can comprise a variety of features, including a plurality of valve leaflets, a frame assembly configured to support the plurality of valve leaflets and define a plurality of commissure supports terminating at an outflow end of the prosthetic valve, a sensor device associated with the frame assembly and configured to generate a sensor signal, for example, a sensor signal indicating deflection of one or more of the plurality of commissure supports, and a transmitter assembly configured to receive the sensor signal from the sensor device and wirelessly transmit a transmission signal that is based at least in part on the sensor signal.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: October 18, 2022
    Assignee: Edwards Lifesciences Corporation
    Inventors: Salvador Marquez, Da-Yu Chang, Cindy Woo, Hao-Chung Yang, Lynn T. Dang, Javier A. Sanguinetti, Alexander H. Siemons, Yaron Keidar, Virginia Qi Lin, Brian S. Conklin, Donald E. Bobo, Jr.
  • Patent number: 11462320
    Abstract: Disclosed are systems and methods for providing automated or semi-automated technical support for patients using medical devices, such as continuous glucose monitoring systems. Disclosed embodiments of automated tech support system include collection and storage of copies of streams of medical device data on multiple servers, analysis and comparison of data streams, remote tech support initiation and usage of the automated tech support system for providing improved products and services by storing and analyzing historical tech support data.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: October 4, 2022
    Assignee: Dexcom, Inc.
    Inventors: Andrew Attila Pal, Leif N. Bowman, Eric Cohen, Basab Dattaray, Edward Day, Apurv Ullas Kamath, Aarthi Mahalingam, Dana Denea Minor, Scott A. Moss, Neil Puri, Eli Reihman, Conrad Woods, Laurie L. Berg, Jorge Valdes
  • Patent number: 11452466
    Abstract: Applicators for applying an on-skin assembly to skin of a host and methods of their use and/or manufacture are provided. An applicator includes an insertion assembly configured to insert at least a portion of the on-skin assembly into the skin of the host, a housing configured to house the insertion assembly, the housing comprising an aperture through which the on-skin assembly can pass, an actuation member configured to, upon activation, cause the insertion assembly to insert at least the portion of the on-skin assembly into the skin of the host, and a sealing element configured to provide a sterile barrier and a vapor barrier between an internal environment of the housing and an external environment of the housing.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: September 27, 2022
    Assignee: DexCom, Inc.
    Inventors: Joseph J. Baker, Philip Thomas Pupa, Timothy Joseph Goldsmith, Jonathan Bodnar, Jason Halac, John Michael Gray, Neal Davis Johnston, Justen Deering England, Peter C. Simpson, Paul V. Neale, Jennifer Blackwell, Maria Noel Brown Wells, Kenneth Pirondini, Andrew Michael Reinhardt, Mark Douglas Kempkey, Young Woo Lee, Warren Terry, Patrick John Castagna, David A. Keller, Randall Scott Koplin, Andrew Joncich, Nirav Bhatt
  • Patent number: 11452467
    Abstract: An analyte monitoring system includes an analyte sensor, a transceiver, and a display device. The analyte sensor may include an analyte indicator that exhibits one or more detectable properties based on an amount or concentration of an analyte in proximity to the analyte indicator. The transceiver may receive first sensor data directly from the analyte sensor and may calculate first analyte information using at least the received first sensor data. The display device may receive second sensor data directly from the analyte sensor and calculates second analyte information using at least the received second sensor data. The transceiver may convey the first analyte information, and the display device may receive the first analyte information conveyed by the transceiver and display the first and second analyte information.
    Type: Grant
    Filed: December 10, 2019
    Date of Patent: September 27, 2022
    Assignee: Senseonics, Incorporated
    Inventors: James Masciotti, Abhi Chavan
  • Patent number: 11439326
    Abstract: An analyte sensor including an antiglycolytic agent or a precursor thereof and a chelating agent that stabilizes the antiglycolytic agent positioned proximate to the working electrode of the sensor. Also provided are systems and methods of using the electrochemical analyte sensors in analyte monitoring.
    Type: Grant
    Filed: January 21, 2019
    Date of Patent: September 13, 2022
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Tianmei Ouyang, Zenghe Liu, Hyun Cho, Benjamin J. Feldman
  • Patent number: 11399753
    Abstract: An electrochemical sensor is disclosed. The sensor has a substrate having a proximal part and an elongated distal part. Electrodes are formed on the distal part. The working electrode forms a conductive trace and multiple electrode pads are arranged along and connected by conductive trace. The electrode pads include a corrosive conductive layer covered by a non-corrosive conductive layer. The corrosive conductive layer is a metal less noble or as noble as Ag, and the non-corrosive conductive is a metal more noble than Ag. An insulating layer on the substrate has openings in the areas of the electrode pads. A protective measure for the corrosive conductive layer can be provided, such as having the insulating layer at least partially overlap the electrode pad edges, or providing at least one of the electrode pads with an elongated shape along the smaller dimension of the distal part.
    Type: Grant
    Filed: April 21, 2020
    Date of Patent: August 2, 2022
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Sabine Achmann, Stephan-Michael Frey, Sebastian Pankalla
  • Patent number: 11395917
    Abstract: Neurostimulation is performed using electrical AC and/or DC stimulation pulses. Brain and/or spinal cord stimulation of a patient is achieved using an implanted neurostimulation device. Neurostimulation is performed using AC and/or DC stimulation pulses combined with a safe operation in DC mode by discharging build-up loads at the interfaces of the electrodes through short circuiting such stimulation electrodes with a counter electrode, for example a common ground electrode.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: July 26, 2022
    Assignee: PRECISIS GmbH
    Inventors: Angela Liedler, Gregor Remmert, Dumitru-Ovidiu-Silviu Coman
  • Patent number: 11382540
    Abstract: Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: July 12, 2022
    Assignee: DexCom, Inc.
    Inventors: Jason Halac, John Charles Barry, Becky L. Clark, Chris W. Dring, John Michael Gray, Kris Elliot Higley, Jeff Jackson, David A. Keller, Ted Tang Lee, Jason Mitchell, Kenneth Pirondini, David Rego, Ryan Everett Schoonmaker, Peter C. Simpson, Craig Thomas Gadd, Kyle Thomas Stewart, John Stanley Hayes
  • Patent number: 11373347
    Abstract: An integrated system for the monitoring and treating diabetes is provided, including an integrated receiver/hand-held medicament injection pen, including electronics, for use with a continuous glucose sensor. In some embodiments, the receiver is configured to receive continuous glucose sensor data, to calculate a medicament therapy (e.g., via the integrated system electronics) and to automatically set a bolus dose of the integrated hand-held medicament injection pen, whereby the user can manually inject the bolus dose of medicament into the host. In some embodiments, the integrated receiver and hand-held medicament injection pen are integrally formed, while in other embodiments they are detachably connected and communicated via mutually engaging electrical contacts and/or via wireless communication.
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: June 28, 2022
    Assignee: DexCom, Inc.
    Inventors: Apurv Ullas Kamath, Richard C. Yang, Jacob S. Leach, Nelson Quintana
  • Patent number: 11350857
    Abstract: Various analyte sensor systems for controlling activation of analyte sensor electronics circuitry are provided. Related methods for controlling analyte sensor electronics circuitry are also provided. Various analyte sensor systems for monitoring an analyte in a host are also provided. Various circuits for controlling activation of an analyte sensor system are also provided. Analyte sensor systems utilizing a state machine having a plurality of states for collecting a plurality of digital counts and waking a controller responsive to a wake up signal are also provided. Related methods for such analyte sensor systems are also provided. Systems for controlling activation of analyte sensor electronics circuitry utilizing a magnetic sensor are further provided. One or more display device configured to display one or more analyte concentration values are also provided.
    Type: Grant
    Filed: May 1, 2019
    Date of Patent: June 7, 2022
    Assignee: Dexcom, Inc.
    Inventors: Jason Halac, Sebastian Bohm, Vincent Peter Crabtree, David DeRenzy, Mark S. Dervaes, Nicholas Kalfas, Zebediah L. McDaniel, Michael Levozier Moore, Todd Andrew Newhouse, Michael A. Ploof, Stephen Alan Reichert, Peter C. Simpson, Alexander Leroy Teeter, Rodolfo Garcia, Jaroslaw Piotrowiak, Thomas George O'Connell, Arlene G. Doria
  • Patent number: 11351537
    Abstract: A method for forming a biological microdevice includes applying a biocompatible coarse scale additive process with an additive device and a biocompatible material to form an object. The coarse scale is a dimension not less than about 100 ?m. The method also includes applying a biocompatible fine scale subtractive process with a subtractive device to the object. The fine scale is a dimension not greater than about 1000 ?m. The method also includes moving the object between the additive device and the subtractive device. A system is also provided for performing the above method and includes the additive device, the subtractive device, a means for transporting the object between the additive device and subtractive device and a processor with a memory including instructions to perform one or more of the above method steps.
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: June 7, 2022
    Assignee: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Swaminathan Rajaraman, Avra Kundu, Tariq Ausaf
  • Patent number: 11331019
    Abstract: Nanoparticle-fibrous membrane composites are provided as tunable interfacial scaffolds for flexible chemical sensors and biosensors by assembling gold nanoparticles (Au NPs) in a fibrous membrane. The gold nanoparticles are functionalized with organic, polymeric and/or biological molecules. The fibrous membranes may include different filter papers, with one example featuring a multilayered fibrous membrane consisting of a cellulose nanofiber (CN) top layer, an electrospun polyacrylonitrile (PAN) nanofibrous midlayer (or alternate material), and a nonwoven polyethylene terephthalate (PET) fibrous support layer, with the nanoparticles provided on the fibrous membranes through interparticle molecular/polymeric linkages and nanoparticle-nanofibrous interactions. Molecular linkers may be employed to tune hydrogen bonding and electrostatic and/or hydrophobic/hydrophilic interactions to provide sensor specificity to gases or liquids. The sensors act as chemiresistor-type sensors.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: May 17, 2022
    Assignee: The Research Foundation for The State University of New York
    Inventors: Chuan-Jian Zhong, Mark D. Poliks, Benjamin S. Hsiao, Ning Kang, Shan Yan, Jing Li, Shiyao Shan, Jin Luo
  • Patent number: 11304664
    Abstract: A system and method provides a glucose report for determining glycemic risk based on an ambulatory glucose profile of glucose data over a time period, a glucose control assessment based on median and variability of glucose, and indicators of high glucose variability. Time of day periods are shown at which glucose levels can be seen. A median glucose goal and a low glucose line provide coupled with glucose variability provide a view into effects that raising or lowering the median goal would have. Likelihood of low glucose, median glucose compared to goal, and variability of glucose below median provide probabilities based on glucose data. Patterns can be seen and provide guidance for treatment.
    Type: Grant
    Filed: December 15, 2020
    Date of Patent: April 19, 2022
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Erwin S. Budiman, Gary A. Hayter, Kenneth J. Doniger, Timothy C. Dunn, Nathan C. Crouther, Glenn Berman, Howard A. Wolpert
  • Patent number: 11300561
    Abstract: Methods for data processing and control for a medical communication system are provided, including determining a sensitivity value for each sensor of a batch of in vivo analyte sensors; determining a sensitivity variation for each sensor of the batch; determining a mean sensitivity based on the sensitivity value determined for each sensor of the batch when it is determined that the determined sensitivity variation does not exceed a tolerance threshold level; associating a sensor code with each sensor of the batch of in vivo analyte sensors when the mean sensitivity is within a predetermined sensitivity range, wherein the sensor code associated with each sensor is based on a characteristic of the associated sensor; and storing the sensor code associated with at least one sensor of the batch configured to generate signals corresponding to monitored analyte level in a memory of a data processing device associated with the sensor.
    Type: Grant
    Filed: September 13, 2021
    Date of Patent: April 12, 2022
    Assignee: ABBOTT DIABETES CARE, INC.
    Inventors: Gary Alan Hayter, Geoffrey V. McGarraugh, Andrew H. Naegeli, John Charles Mazza, Benjamin Jay Feldman
  • Patent number: 11298537
    Abstract: A periocular assembly that is configured to be positioned in the fornix of an eye of the user includes a ring; a plurality of electrodes spaced along the ring; a microcontroller operably coupled to the plurality of electrodes; and a sensor assembly coupled to the ring and operably coupled to the microcontroller. A method of stimulating a lacrimal gland of the user includes monitoring eye condition(s) using the sensor assembly; determining, based on the monitored eye condition(s) and using the microcontroller, if the monitored eye conditions(s) exceed a predetermined threshold; and activating, using the microcontroller and in response to the monitored eye condition(s) exceeding the predetermined threshold, the plurality of electrodes to stimulate the lacrimal gland of the user.
    Type: Grant
    Filed: March 25, 2020
    Date of Patent: April 12, 2022
    Assignee: TWENTY TWENTY THERAPEUTICS LLC
    Inventor: Christian Gutierrez
  • Patent number: 11295855
    Abstract: Disclosed are systems and methods for providing automated or semi-automated technical support for patients using medical devices, such as continuous glucose monitoring systems. Disclosed embodiments of automated tech support system include collection and storage of copies of streams of medical device data on multiple servers, analysis and comparison of data streams, remote tech support initiation and usage of the automated tech support system for providing improved products and services by storing and analyzing historical tech support data.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: April 5, 2022
    Assignee: Dexcom, Inc.
    Inventors: Andrew Attila Pal, Leif N. Bowman, Eric Cohen, Basab Dattaray, Edward Day, Apurv Ullas Kamath, Aarthi Mahalingam, Dana Minor, Scott A. Moss, Neil Puri, Eli Reihman, Conrad Woods, Laurie L. Berg, Jorge Valdes
  • Patent number: 11287648
    Abstract: A near-eye optic includes a substrate having a clear aperture for propagating light. An inconspicuous electrical circuit is supported by the substrate in the clear aperture of the substrate. The inconspicuous electrical circuit includes a plurality of inconspicuous conductive traces disposed in an inconspicuous pattern and electrically coupled to a plurality of inconspicuous electrical components. The inconspicuous pattern may include e.g. an asymmetric pattern, an aperiodic pattern, a pseudo-random pattern, a meandering pattern, a periodic pattern modulated with pseudo-random perturbations, or a non-rectangular pattern modulated with pseudo-random perturbations.
    Type: Grant
    Filed: January 8, 2021
    Date of Patent: March 29, 2022
    Assignee: Facebook Technologies, LLC
    Inventors: Karol Constantine Hatzilias, Robin Sharma, Christopher Yuan Ting Liao, Andrew Ouderkirk
  • Patent number: 11272866
    Abstract: A system and method for monitoring body chemistry of a user, the system comprising: a housing supporting: a microsensor comprising a first and second working electrode, a reference electrode, and a counter electrode, and configured to access interstitial fluid of the user, and an electronics subsystem comprising a signal conditioning module that receives a signal stream, from the microsensor, wherein the electronics subsystem is configured to detect an impedance signal derived from two of the first working electrode, the second working electrode, the reference electrode, and the counter electrode; and a processing subsystem comprising: a first module configured to generate an analysis indicative of an analyte parameter of the user and derived from the signal stream and the impedance signal, and a second module configured to transmit information derived from the analysis to the user, thereby facilitating monitoring of body chemistry of the user.
    Type: Grant
    Filed: March 10, 2021
    Date of Patent: March 15, 2022
    Assignee: One Drop Biosensor Technologies, LLC
    Inventors: Ashwin Pushpala, Matthew Chapman, Alan Szmodis, Abhijit Ghosh
  • Patent number: 11272885
    Abstract: A microsensor and method of manufacture for a microsensor, comprising an array of filaments, wherein each filament of the array of filaments comprises a substrate and a conductive layer coupled to the substrate and configured to facilitate analyte detection. Each filament of the array of filaments can further comprise an insulating layer configured to isolate regions defined by the conductive layer for analyte detection, a sensing layer coupled to the conductive layer, configured to enable transduction, and a selective coating coupled to the sensing layer, configured to facilitate detection of specific target analytes/ions. The microsensor facilitates detection of at least one analyte present in a body fluid of a user interfacing with the microsensor.
    Type: Grant
    Filed: July 29, 2020
    Date of Patent: March 15, 2022
    Assignee: One Drop Biosensor Technologies, LLC
    Inventors: Ashwin Pushpala, Matthew Chapman, Alan Szmodis
  • Patent number: 11266350
    Abstract: An adhesive patch for attaching at least one EM probe to a subject's body, the adhesive patch comprising a planar member having at least one layer of radiation absorbing material and having at least one opening formed within the radiation absorbing material to allow the propagation of EM radiation via the opening from one side of the planar member to the other. The adhesive patch further comprises at least one layer of an adhesive attached over at least part of a bottom surface of the planar member, which adhesive layer may be applied so as to form a pattern on the bottom surface, the pattern comprising at least one adhesive-covered portion and at least one adhesive-free portion.
    Type: Grant
    Filed: May 2, 2013
    Date of Patent: March 8, 2022
    Assignee: Sensible Medical Innovations Ltd.
    Inventors: Amir Saroka, Shlomi Bergida
  • Patent number: 11246531
    Abstract: An exercise feedback system determines muscle fatigue measurements using physiological data generated by a sensor-equipped athletic garment. The muscle fatigue measurement is determined by analyzing the frequency spread of the physiological data. The exercise feedback system may customize exercise programs, determine risks of injury, or generate biofeedback for presentation on graphical user interfaces using the muscle fatigue measurements. The exercise feedback system accesses pre-determined muscle fatigue measurement models that define criteria for the aforementioned features. For instance, if an athlete is becoming fatigued and exercising with improper form based on a muscle fatigue measurement, the exercise feedback system modifies the athlete's exercise program to help target and improve the athlete's weaknesses as well as to prevent injury.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: February 15, 2022
    Assignee: Mad Apparel, Inc.
    Inventors: Lev Korzinov, Ankit Gordhandas, Christopher John Wiebe