Abstract: An electrode assembly for sensing an electrochemical signal diffused from a source to a working electrode which is comprised of a plurality of substantially separated working electrode surfaces is disclosed. The electrode of the invention is comprised of 1) a working electrode made up of a plurality of working electrode surfaces or components and 2) a electrically insulating gap defined by adjacent edges of 1) insulating the working electrode surfaces or components from each other. The working electrode components are configured to receive electrochemical signal from two or preferably three dimensions simultaneously. The working electrode components configured over the same surface as a single electrode provide (1) an improved signal to noise ratio as compared to a single electrode by reducing noise, and (2) provide an overall enhanced signal after sensing for a given period of time.

Abstract: A method is provided for continually or continuously measuring the concentration of target chemical analytes present in a biological system, and processing analyte-specific signals to obtain a measurement value that is closely correlated with the concentration of the target chemical analyte in the biological system. One important application of the invention involves a method for signal processing in a system for monitoring blood glucose values.

Abstract: The invention aims to provide a health care instrument adapted to measure oxidation-reduction potential in human being, animal, fish and shellfish, plant, vegetable as well as water, air or earth surrounding those organisms and thereby to determine a level of active oxygen in such subject so that the measured data may be used for health care. The object set forth above is achieved by a health care instrument containing an oxidation-reduction potential measuring function comprising a main body, a power source consisting of a battery with or without a battery charger and an oxidation-reduction potential measuring unit both contained in the main body, a measuring probe attached to one end of the main body, a sensor included in the measure probe so as to be connected to the oxidation-reduction potential measuring unit, and a display unit provided on a part of the main body to display the measured oxidation-reduction potential value.

Abstract: A method is provided for continually or continuously measuring the concentration of target chemical analytes present in a biological system, and processing analyte-specific signals to obtain a measurement value that is closely correlated with the concentration of the target chemical analyte in the biological system. One important application of the invention involves a method for signal processing in a system for monitoring blood glucose values.

Abstract: Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. One important application of the invention involves a method and device for monitoring blood glucose values.

Abstract: An electro-medical apparatus for receiving bio-electrical signals from a human body. At least 17 electrodes are applied to specific areas of the body of the patient. The signals received therein are automatically processed by a personal computer which analyzes the health state of the patient by way of specific software. An expert system can additionally be included which includes control software, analysis software and interpretation software to provide the physician with first indication data about the health of the patient and with possible modes of intervention, so that the physician can arrive at a substantially definitive interpretation of the health state of the patient.

Abstract: A device and method for determining the concentration of an analyte, particularly a chloride ion, in a liquid sample are particularly useful to screen for cystic fibrosis in an individual. In a preferred embodiment, the device takes the form of a patch comprising an absorbent material sandwiched between two liquid-impermeable layers. Chloride ions in the liquid sample complex with a chloride-detecting agent dispersed throughout the absorbent material to form a visible precipitate, preferably silver chloride. A pH indicator is also dispersed throughout the absorbent material, allowing the position of the water front to be monitored thereby permitting calculation of chloride concentration from a partially filled patch.

Abstract: A portion a the machine which the operator regularly engages with his or her hands has incorporated therein a plurality of passageways (14) through which a vacuum is applied to draw vapor which is emitted by the hands of the individual. Vapor from the individual's hands is drawn through a sampling apparatus. The sampling apparatus contains an electrical coil (32, 36, 42, 46) which is coated with a composite metal-nonmetal catalytic substance which causes ethanol to oxidize at the coil. When ethanol-containing vapor passes over the coil, oxidation at the coil causes an electrical charge to build up on the coil. The charge build-up is detected and processed in a discriminating type of electrical circuit which incorporates a wheatstone bridge or a constant-current loop. The resulting signal is further processed then ultimately used to estimate the alcohol content of the individual.

Abstract: A method for continuous tracking of blood alcohol, is comprised of 1) a potential- and diffusion-controlled electrochemical solid polymer electrolyte sensor that continuously and concurrently measures very low concentrations of ethanol vapor at the surface of the skin as well as skin properties such as temperature and ionic conductivity, 2) a sensor control circuit, and 3) a data acquisition-recording device. Sensitive and reproducible measurements of ethanol over a wide population range is obtained by simultaneously maintaining the potential of the sensing electrode constant at a voltage above the rest potential of the platinum/air (O.sub.2) electrode and by use of a thin, permselective diffusion-control membrane over the sensing electrode, and in series with the human stratum corneum membrane. The electrochemical oxidation current is a direct measure of the local ethanol vapor concentration over the skin surface.