Abstract: A device for mounting an electrochemical sensor unit to a skin surface of a human being comprises a mounting member having a circumferential wall, an adhesive tape at a lower end of the circumferential wall for adhering the mounting member to the skin surface, and a sealing member. The sealing member provides a liquid tight seal between a lumen or measuring chamber defined between the skin surface, the mounting device and the sensor unit, the measuring chamber being normally filled with a contact liquid. Alternatively, the sealing member is provided on the sensor unit. The provision of the sealing member renders the system less vulnerable to force impacts and reduces the risk of flawed measurements due to atmospheric air in the measuring chamber. The electrochemical sensor unit may e.g. be suitable for transcutaneous measurement of partial carbon dioxide pressure (pCO2) or partial oxygen pressure (pO2).

Abstract: A sensor adapter is described for the noninvasive positioning of a sensor, especially of an electrochemical sensor, in a medium. The sensor adapter comprises an accommodating channel, in which the sensor can be positioned and the one end region of which is closed off by a semipermeable membrane. Moreover, the sensor adapter comprises a hollow cylindrical sealing structure, which is disposed within the accommodating channel coaxially with the longitudinal axis of the latter and with which the sensor can be disposed gas tight adjacent to the semipermeable membrane.

Abstract: In aspects of the present disclosure, a no coding blood glucose monitoring unit including a calibration unit is integrated with one or more components of an analyte monitoring system to provide compatibility with in vitro test strip that do not require a calibration code is provided. Also disclosed are methods, systems, devices and kits for providing the same.

Abstract: Disclosed herein is an analyte sensing device capable of continuously monitoring metabolic levels of a plurality of analytes. The device comprises an external unit, which, for example, could be worn around the wrist like a wristwatch or could be incorporated into a cell phone or PDA device, and an implantable sensor platform that is suitable, for example, for implantation under the skin. The external device and the internal device are in wireless communication. In one embodiment, the external device and the internal device are operationally linked by a feedback system. In one embodiment, the internal device is encapsulated in a biocompatible coating capable of controlling the local tissue environment in order to prevent/minimize inflammation and fibrosis, promote neo-angiogenesis and wound healing and this facilitate device functionality.

Abstract: In aspects of the present disclosure, a no coding blood glucose monitoring unit including a calibration unit is integrated with one or more components of an analyte monitoring system to provide compatibility with in vitro test strip that do not require a calibration code is provided. Also disclosed are methods, systems, devices and kits for providing the same.

Abstract: A medical device is provided comprising a transcutaneous device unit and a process unit. The transcutaneous device unit may comprise a transcutaneous device for transporting a fluid through a skin portion of a subject, and a mounting surface adapted for application to the skin of the subject. The process unit may comprise a reservoir adapted to contain a fluid drug, the reservoir comprising an outlet means allowing the transcutaneous device to be arranged in fluid communication with an interior of the reservoir, and an expelling assembly for expelling a fluid drug out of the reservoir and through the skin of the subject via the transcutaneous device. The transcutaneous device unit and the process unit further comprise coupling means allowing the reservoir unit to be secured to the transcutaneous device unit in the situation of use. By this arrangement a two-unit system is provided which can be used in a convenient and cost-effective manner.

Abstract: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.

Abstract: A system for measuring an analyte of interest, particularly carbon dioxide, dissolved in a fluid media of a patient including a nanoelectronic sensor and a measurement instrument in communication with the sensor and configured to receive at least a signal from the sensor indicative of a response of the sensor to at least the analyte of interest.

Abstract: A probe for use in a patient having a vessel carrying blood to ascertain characteristics of the blood having a cannula adapted to be inserted into the vessel of the patient. The cannula has a length so that when the distal extremity is in the vessel of the patient the proximal extremity is accessible outside of the patient. A gas sensor assembly is carried within the distal extremity of the cannula for determining gas characteristics of the blood in the vessel. A pressure sensor is carried within the distal extremity of the cannula for determining the pressure of the blood in the vessel.

Abstract: In a process for measuring partial transcutaneous CO2 pressure on an earlobe by means of a sensor having a measuring device for measuring the partial transcutaneous CO2 pressure and a heating system for heating a sensor contact surface for contact with the earlobe, the sensor contact surface is heated. During a first phase, the sensor contact surface is kept at an elevated temperature of at least 41.5° C. in order to prevent the measured value of partial transcutaneous CO2 pressure from exceeding, due to the measurement process itself, the partial transcutaneous CO2 pressure achieved after stabilization. The temperature of the sensor contact surface is then reduced to between 37° C. and 41° C. This facilitates considerably faster evaluation of the measured values.

Abstract: An apparatus for measuring skin permeable gas, which can be used to obtain clinical information by noninvasive and bloodless operations and are useful for in-home medical care and health management. The device for collecting skin permeable gas includes a finger-stall including a coupler, and one or more connections that are connectable with the coupler and include a stopcock.

Abstract: A method for measuring and determining urea level in human blood by reverse iontophoresis comprising the following steps of: placing an anode electrode on skin, placing a container comprising a solution including urease and a cathode electrode on skin, applying electric current to the anode electrode and the cathode electrode so that an electrical circuit is established there between, whereby urea molecules migrate from blood into the container, determining the urea level in the blood by the changes in the pH of the urease solution.

Abstract: A tissue interface device (10) suitable for positioning on or about one or more artificial openings in a biological membrane of an organism and for coupling to a monitor and control unit and a vacuum source. The tissue interface device (10) comprises a housing (100), a sensor channel (130), and a sensor (150). The housing (100) defines an orifice (120), the orifice (120) having an open inlet port (122) on the bottom end (102) of the housing (100) and a distal end (124) that is in fluid communication with the sensor channel (130). The orifice (120) is in fluid communication with fluid that flows from the artificial opening formed in the biological membranes. The sensor channel (130) is for coupling to, and fluid communication therewith, the vacuum source. The sensor (150) is positioned in the sensor channel (130) in a flow path of the fluid for sensing a characteristic of the fluid as it flows out from the artificial opening. The sensor generates a sensor signal representative thereof.

Abstract: An iontophoretic power supply comprising hardware and software. The hardware includes means for interfacing with an iontophoretic output device; microprocessor means and a computer readable medium. The software is recorded on the computer readable medium and executable by the microprocessor means. The software is capable of performing the steps of facilitating the providing of at least one operating parameter by a user and applying the provided operating parameters to an interfaced iontophoretic device.

Abstract: A sensor for the measurement of physiological parameters in the blood, including at least one measuring apparatus and a digital sensor signal processor which is arranged in the sensor, and which is connected in a signal conducting manner to the measuring apparatus. The sensor may output a digital output signal, which may be transmitted to a signal evaluation device using a connection cable.

Abstract: A non-invasive device for the quantitative determination of the level of dants and/or antioxidants in the skin of a subject includes a reference electrode and a working electrode which are connected to an electrical voltage measuring device; and a test solution container which is open at a bottom side thereof and which is placed on the skin of the subject and is sealingly but releasably affixed to the skin, is filled with a test solution, and which permits contact between the test solution and the skin. The test solution container further includes a top opening through which the electrodes are immersed in the test solution.

Abstract: An improved insertion set is provided for transcutaneous placement of a sensor such as a glucose sensor at a selected site within the body of a patient. The insertion set comprises a mounting base defining an upwardly open channel for receiving and supporting a flexible thin film sensor, in combination with a cap assembled with said mounting base to capture and retain a proximal end of the sensor within said channel. The sensor further includes a distal segment with sensor electrodes thereon which protrudes from the mounting base for transcutaneous placement, wherein the sensor distal segment is slidably carried by a slotted insertion needle fitted through the assembled base and cap. Placement of the insertion set against the patient's skin causes the insertion needle to pierce the skin to carry the sensor electrodes to the desired subcutaneous site, after which the insertion needle can be slidably withdrawn from the insertion set.

Abstract: A method for continuous tracking of blood alcohol, is comprised of 1) a potential- and diffusion-controlled electrochemical solid polymer electrolyte sensor that continuously and concurrently measures very low concentrations of ethanol vapor at the surface of the skin as well as skin properties such as temperature and ionic conductivity, 2) a sensor control circuit, and 3) a data acquisition-recording device. Sensitive and reproducible measurements of ethanol over a wide population range is obtained by simultaneously maintaining the potential of the sensing electrode constant at a voltage above the rest potential of the platinum/air (O.sub.2) electrode and by use of a thin, permselective diffusion-control membrane over the sensing electrode, and in series with the human stratum corneum membrane. The electrochemical oxidation current is a direct measure of the local ethanol vapor concentration over the skin surface.