Determining Ion Concentration/partial Pressure Patents (Class 600/348)
  • Patent number: 10338025
    Abstract: A meter is adapted for measuring concentrations of a chemical in a flowing solution. The meter has a barrier that shields a sensor from the high turbulence of the solution flow. One or more membranes can be employed to selectively filter out various ions or other chemicals.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: July 2, 2019
    Assignee: SENTIENT TECHNOLOGIES, INC
    Inventor: Frederick Quincy Johnson
  • Patent number: 10107779
    Abstract: Embodiments of sensing devices include one or more integrated circuit (IC) die, a housing, and a fluid barrier material. Each IC die includes an electrode-bearing surface and a contact surface. One of the die includes an SFET with a sensing electrode proximate to the electrode-bearing surface. The same or a different die includes a reference electrode proximate to the electrode-bearing surface. The die(s) also include IC contacts at the contact surface(s), and conductive structures coupled between the SFET, the reference electrode, and the IC contacts. The housing includes a mounting surface, and housing contacts formed at the mounting surface. The IC contacts are coupled to the housing contacts. The fluid barrier material is positioned between the mounting surface and the IC die. The fluid barrier material provides a fluid barrier between the IC and housing contacts and a space that encompasses the sensing electrode and the reference electrode.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: October 23, 2018
    Assignee: NXP USA, INC.
    Inventors: Raymond M. Roop, Jose Fernandez Villasenor, Stephen R. Hooper, Patrice M. Parris
  • Patent number: 10016154
    Abstract: A sensor system is disclosed. The system comprises: a solid substrate having a front side and a back side, a sensing assembly formed on the front side and being configured to provide electrochemical sensing, a plurality of electrical contacts, formed on the back side and being in electrical communication with the sensing assembly via a plurality of interconnects passing through the substrate and extending at least from the front side to the back side, and a mounting member configured for mounting the back side onto a tip of a movable device.
    Type: Grant
    Filed: February 5, 2015
    Date of Patent: July 10, 2018
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Yosi Shacham-Diamand, Heftsi Ragones, Amihay Freeman, David Schreiber
  • Patent number: 9594047
    Abstract: A coated-wire potentiometric sensor comprising an electronically conducting substrate electrode coated with an ionically conductive sensing layer and an outermost surface consisting of or comprising in and/or on a first molecular species which is capable of reversibly adsorbing a second molecular species and a method for measuring the affinity between a first molecular species and a second molecular species comprising the steps of: providing a potentiometric sensor of the coated-wire type having an outermost surface; adapting said outermost surface so that consists of or comprises said first molecular species; placing said sensor in a system for the recording of sensorgrams; recording a sensorgram of the adsorption of a second molecular species on said first molecular species of or comprised in and/or on said adapted outermost surface.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: March 14, 2017
    Assignee: UNIVERSITEIT ANTWERPEN
    Inventors: Karolien De Wael, Lucien Nagels, Guido Van Camp
  • Patent number: 9278171
    Abstract: The invention relates to a device for the citrate anti-coagulated extracorporeal blood purification comprising: an extracorporeal blood purification system comprising an extracorporeal blood circuit (202), which comprises a dialysis unit (205), a blood inflow (203) and a blood discharge (204), a citrate metering device (212) for supplying citrate at a citrate supply point (213) upstream of the dialysis unit (205), a substitution medium metering device (214) for supplying a substitution medium at a substitution medium supply point (215) downstream from the dialysis unit (205), at least one ion concentration measuring means (224) for measuring bivalent cations and a controller (225), wherein the controller (225) is adapted to regulate the metering of the substitution medium as a function of a comparison between a setpoint value range and the ion concentration measured by means of the ion concentration measuring means (224), wherein the ion concentration measuring means (224) is adapted for the continuous gener
    Type: Grant
    Filed: August 28, 2008
    Date of Patent: March 8, 2016
    Assignee: Zentrum fur Biomedizinische Technologie der Donau-Universitat Krems
    Inventors: Martin Brandl, Jens Hartmann, Karin Strobl, Dieter Falkenhagen
  • Patent number: 9192328
    Abstract: Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk.
    Type: Grant
    Filed: September 23, 2009
    Date of Patent: November 24, 2015
    Assignee: DexCom, Inc.
    Inventors: James H. Brauker, Victoria Carr-Brendel, Paul V. Goode, Apurv U. Kamath, James P. Thrower, Ben Xavier
  • Patent number: 9066695
    Abstract: An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte.
    Type: Grant
    Filed: April 12, 2007
    Date of Patent: June 30, 2015
    Assignee: Abbott Diabetes Care Inc.
    Inventors: James Say, Michael F. Tomasco, Adam Heller, Yoram Gal, Behrad Aria, Ephraim Heller, Phillip John Plante, Mark S. Vreeke, Keith A. Friedman, Fredric C. Colman
  • Publication number: 20150141767
    Abstract: Provided are devices and methods capable of interfacing with biological tissues, such as organs like the heart, in real-time and using techniques which provide the ability to monitor and control complex physical, chemical, biochemical and thermal properties of the tissues as a function of time. The described devices and methods utilize micro scale sensors and actuators to spatially monitor and control a variety of physical, chemical and biological tissue parameters, such as temperature, pH, spatial position, force, pressure, electrophysiology and to spatially provide a variety of stimuli, such as heat, light, voltage and current.
    Type: Application
    Filed: October 2, 2014
    Publication date: May 21, 2015
    Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, WASHINGTON UNIVERSITY IN ST. LOUIS
    Inventors: John A. ROGERS, Igor EFIMOV, Sarah GUTBROD, Lizhi XU, Andrew BONIFAS, Richard Chad WEBB, Ahyeon KOH
  • Publication number: 20150126835
    Abstract: Novel membranes comprising various polymers containing heterocyclic nitrogen groups are described. These membranes are usefully employed in electrochemical sensors, such as amperometric biosensors. More particularly, these membranes effectively regulate a flux of analyte to a measurement electrode in an electrochemical sensor, thereby improving the functioning of the electrochemical sensor over a significant range of analyte concentrations. Electrochemical sensors equipped with such membranes are also described.
    Type: Application
    Filed: January 12, 2015
    Publication date: May 7, 2015
    Applicant: Abbott Diabetes Care Inc.
    Inventors: Fei Mao, Hyun Cho
  • Publication number: 20150112175
    Abstract: A body-mountable urea sensing device includes an electrochemical sensor embedded in a polymeric material configured for mounting to a surface of an eye. The electrochemical sensor includes a working electrode, a reference electrode, and a reagent localized near the working electrode that selectively reacts with urea. A potentiometric voltage between the working electrode and the reference electrode is related to a concentration of urea in a fluid to which the electrochemical sensor is exposed; the voltage is measured by the body-mountable device and wirelessly communicated.
    Type: Application
    Filed: October 17, 2013
    Publication date: April 23, 2015
    Applicant: Google Inc.
    Inventors: Huanfen Yao, Zenghe Liu
  • Patent number: 9014775
    Abstract: An apparatus, systems, and methods related to determining an identity and a concentration of an intravenous fluid. The apparatus, the systems, and the methods described herein may provide near real-time monitoring and/or determination of an identity of components of the intravenous fluid. A concentration and the identity of all of the components of the intravenous fluid may be identified simultaneously.
    Type: Grant
    Filed: September 3, 2010
    Date of Patent: April 21, 2015
    Assignee: S.E.A. Medical Systems, Inc.
    Inventors: James W. Bennett, Leonid F. Matsiev
  • Publication number: 20150105640
    Abstract: This document provides methods and materials related to the non-invasive measurement of analytes in blood.
    Type: Application
    Filed: December 19, 2014
    Publication date: April 16, 2015
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Paul A. Friedman, Kevin E. Bennet, Charles J. Bruce, Virend K. Somers
  • Patent number: 9000929
    Abstract: Methods and systems for providing data communication in medical systems are disclosed.
    Type: Grant
    Filed: November 22, 2013
    Date of Patent: April 7, 2015
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Gary Alan Hayter, Martin J. Fennell, Lei He, Mark Kent Sloan
  • Publication number: 20150080692
    Abstract: The invention provides an electrophysiological analysis system, in particular for detecting pathological states. This system comprises: electrodes intended to be placed in different regions of the body that are well away from each other; an adjustable DC voltage source for generating successive DC voltage pulses varying in magnitude from one pulse to another, the duration of the pulses being equal to or greater than about 0.2 seconds; a switching circuit for selectively connecting a pair of active electrodes to the voltage source and for connecting at least one other high-impedance electrode; and a measurement circuit for recording data representative of the current in the active electrodes and potentials on at least certain high-impedance connected electrodes in response to the application of said pulses. The range of voltages covered causes, from one pulse to another, the appearance or disappearance of electrochemical phenomena in the vicinity of the active electrodes.
    Type: Application
    Filed: November 25, 2014
    Publication date: March 19, 2015
    Applicant: Impeto Medical
    Inventors: Philippe Brunswick, Nicolas Bocquet
  • Publication number: 20150057516
    Abstract: Novel methods and systems for monitoring the health of an eye are disclosed. For example, a resonant circuit may be fabricated on a contact lens and this circuit may be coupled to a second circuit having the same resonant current frequency. A change in a property of the eye fluid contacted by the sensor in the contact lens is communicated to an external device and a remedying action is suggested to the wearer.
    Type: Application
    Filed: August 21, 2014
    Publication date: February 26, 2015
    Inventors: Muhammad MUJEEB-U-RAHMAN, Axel SCHERER
  • Publication number: 20140349005
    Abstract: Disclosed herein are biosensor systems and related methods for detecting analytes in aqueous and biologic environments. A biosensor system for detecting binding of an analyte of interest may include a detector configured to detect a change in an electrical property on a surface thereof. The detector may be a FET. The system also may include a passive layer disposed on a top surface of the detector. Further, the system may include a hydrophobic layer disposed on the passive layer. The system also may include a receptor-attachment material configured for binding to an analyte. A receptor may bind to the analyte, and the receptor may be attached to the receptor-attachment material. The binding of the analyte to the receptor can cause the change of the electrical property at the surface. In response to the change for example, a current may change for indicating the binding of the analyte to the receptor.
    Type: Application
    Filed: December 3, 2012
    Publication date: November 27, 2014
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Allen Dale Everett, Howard Katz, Kalpana Besar, Weiguo Huang
  • Patent number: 8818477
    Abstract: Methods and systems are disclosed for determining an anaerobic threshold and/or an oxygen consumption rate in a human or animal subject. The methods include exposing a tissue of the subject to illumination radiation, collecting emitted radiation from the tissue, the emitted radiation including a portion of the illumination radiation reflected or transmitted from the tissue, processing the emitted radiation to form a spectrum of the tissue, and determining, based on the spectrum of the tissue, the anaerobic threshold and/or the oxygen consumption rate of the subject.
    Type: Grant
    Filed: July 14, 2008
    Date of Patent: August 26, 2014
    Assignee: University of Massachusetts
    Inventor: Babs R. Soller
  • Publication number: 20140206961
    Abstract: The invention relates generally to in vivo collection of circulating molecules, tumor cells and other biological markers using a collecting probe. The probe is configured for placement within a living organism for an extended period of time to provide sufficient yield of biological marker for analysis. In some embodiments of the invention, active attraction of biological markers are provided. A partial or complete analytic/detection assembly may also be integrated with the probe.
    Type: Application
    Filed: October 28, 2013
    Publication date: July 24, 2014
    Applicant: John Wayne Cancer Institute
    Inventors: David Hoon, Bret Taback, Samuel Shaolian
  • Publication number: 20140088391
    Abstract: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.
    Type: Application
    Filed: October 21, 2013
    Publication date: March 27, 2014
    Applicant: DEXCOM, INC.
    Inventors: Jacob S. Leach, Peter C. Simpson, Richard C. Yang, Mark Brister
  • Patent number: 8608924
    Abstract: According to an embodiment of the invention, a method of determining hydration of a sensor having a plurality of electrodes is disclosed. In particular embodiments, the method couples a sensor electronics device to the sensor and measures the open circuit potential between at least two of the plurality of electrodes. Then, the open circuit potential measurement is compared to a predetermined value. In some embodiments, the plurality of electrodes includes a working electrode, a reference electrode, and a counter electrode. In still further embodiments, the open circuit potential between the working electrode and the reference electrode is measured. In other embodiments, the open circuit potential between the working electrode and the counter electrode is measured. In still other embodiments, the open circuit potential between the counter electrode and the reference electrode is measured.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: December 17, 2013
    Assignee: Medtronic Minimed, Inc.
    Inventors: Kenneth W. Cooper, David Y. Choy, Rajiv Shah, Gopikrishnan Soundararajan, Ratnakar Vejella
  • Patent number: 8599009
    Abstract: Configuration technologies for cost-effectively monitoring indicia of regimen compliance or noncompliance in response to one or more indications of symptoms or actions or other data on data-bearing media or in wireless transmissions, such as implementing techniques for providing or preventing access or otherwise acting on or communicating incremental or definitive indicia of compliance or noncompliance.
    Type: Grant
    Filed: August 16, 2011
    Date of Patent: December 3, 2013
    Assignee: Elwha LLC
    Inventors: Roderick A. Hyde, Edward K. Y. Jung, Jordin T. Kare, Royce A. Levien, Robert W. Lord, Mark A. Malamud, John D. Rinaldo, Jr., Elizabeth A. Sweeney, Lowell L. Wood, Jr.
  • Patent number: 8562528
    Abstract: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.
    Type: Grant
    Filed: November 7, 2008
    Date of Patent: October 22, 2013
    Assignee: Dexcom, Inc.
    Inventors: Jacob S. Leach, Peter C. Simpson, Richard C. Yang, Mark Brister
  • Publication number: 20130158378
    Abstract: An ion-sensitive sensor includes a dielectric layer comprising Al2O3 having a functionalized surface configured to bond with an analyte. The ion-sensitive sensor is immersed in an electrolytic solution containing a concentration of alkali ions. An electrode is arranged to apply an electric potential to the functionalized surface of the ion-sensitive sensor. In some embodiments the ion-sensitive sensor is an ion-sensitive silicon FET. In some embodiments the ion-sensitive sensor is an ion-sensitive polymer FET. In some embodiments, the electrode comprises a perforated gate metal layer disposed on the gate dielectric layer of an ion-sensitive FET, and the functionalized surface is disposed in openings of the perforated gate metal layer. In some embodiments the dielectric layer comprises a multi-layer dielectric stack including at least one Al2O3 layer. In some embodiments the dielectric layer is deposited by atomic layer deposition (ALD).
    Type: Application
    Filed: September 21, 2012
    Publication date: June 20, 2013
    Applicant: THE OHIO STATE UNIVERSITY
    Inventor: THE OHIO STATE UNIVERSITY
  • Patent number: 8275438
    Abstract: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.
    Type: Grant
    Filed: November 7, 2008
    Date of Patent: September 25, 2012
    Assignee: DexCom, Inc.
    Inventors: Peter C. Simpson, Michael J. Estes, Paul V. Neale, Robert Boock, Jacob S. Leach, Richard C. Yang
  • Patent number: 8249318
    Abstract: A method for identifying implanted reconstructive prosthetic devices comprising obtaining a digital radiographic image of a prosthetic implant that has been implanted in a person or animal for which the manufacturer and/or model is unknown; allowing a user to enter into a computer metadata relating to the implant for use as metadata feature values; cleaning up the unknown implant image; rotating, flipping and/or scaling the unknown implant image; extracting features from the unknown implant image according to one or more feature extraction algorithms; and comparing the metadata and extracted feature values for the unknown implant image to feature values for other implant images according to a comparison algorithm to create an overall likelihood score for each of the other implant images.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: August 21, 2012
    Assignee: OsteoWare, Inc.
    Inventors: Mike Schmitt, Troy S. Bergquist, Brian Smithgall
  • Patent number: 8233956
    Abstract: A medical device includes a connector which contacts a sensor to electrically connect the sensor with a measurement circuit in a medical device, a contact terminal which constitutes the connector, and a slide pin which ejects the sensor out of the medical device. The slide pin performs the operation of pushing up the contact terminal contacting the sensor as well as the operation of pushing the sensor out of the medical device. Since the contact terminal is completely lifted up by the inclined surface of the upper end part of the slide pin before the sensor is discarded, there occurs no reaction due to rebound of the contact terminal which might occur at the moment when the contact terminal of the connector is separated from the sensor, and thereby the sensor can be discarded so as to fall freely.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: July 31, 2012
    Assignee: Panasonic Corporation
    Inventors: Shinji Ohama, Eiichiro Izumi
  • Patent number: 8095198
    Abstract: Methods and systems for detecting a biological response indicative of osteolysis or osteolytic pre-conditions in bone.
    Type: Grant
    Filed: January 31, 2006
    Date of Patent: January 10, 2012
    Assignee: Warsaw Orthopedic. Inc.
    Inventors: Jeffrey H. Nycz, Susan J J. Drapeau, William T. Donofrio
  • Patent number: 8055322
    Abstract: Devices and methods for measuring a target ion concentration uses an electrode pair. The pair includes a working electrode and a reference electrode. The working and reference electrodes are ion-selective electrodes (ISEs). The reference ISE can include a sodium ISE. The ISE pair interacts with body fluids where a target ion concentration changes more than sodium ion concentration over time. Some ISE membranes of a pair vary essentially only in the ionophore. An ISE pair can determine the ratio of a target ion concentration to sodium ion concentration in vivo. Periodic measurement of sodium concentration in drawn blood can be used to calibrate an ISE pair and provide target ion concentration as an output. Or, a potassium/sodium ISE pair beneficially monitors potassium concentration changes over time in heart- or kidney-failure patients. Then, manual or automatic titration of a diuretic material can be implemented to maintain a desired potassium concentration.
    Type: Grant
    Filed: February 21, 2008
    Date of Patent: November 8, 2011
    Assignee: Medtronic, Inc.
    Inventor: Qingshan Ye
  • Patent number: 7970449
    Abstract: Embodiments of the present invention provide for raising a background current setting for a biosensor above the actual (measured) background current present (i.e., overestimating the background current), particularly in the hypoglycemic range, to improve sensor accuracy and decrease the chance of glucose value overestimation by the sensor.
    Type: Grant
    Filed: April 12, 2010
    Date of Patent: June 28, 2011
    Assignee: Isense Corporation
    Inventor: W. Kenneth Ward
  • Patent number: 7826880
    Abstract: A physiological sensing device for the measurement of pCO2 includes a closed chamber bounded, at least partially, by a carbon dioxide permeate e membrane (12). There are two electrodes (10) within the chamber. The chamber contains a substantially electrolyte-free liquid in contact with electrodes (10) and the membrane (12). The liquid contains a non-ionic excipient in order to prevent egress of water due to an osmotic gradient across the membrane (12) in use.
    Type: Grant
    Filed: July 18, 2005
    Date of Patent: November 2, 2010
    Assignee: Alertis Medical AS
    Inventors: Tore Omtveit, Peyman Mirtaheri
  • Patent number: 7813780
    Abstract: Embodiments of the invention provide analyte sensors having optimized permselective membranes and methods for making and using such sensors. Embodiments of the invention also provide analyte sensors such as those having porous matrices coated with an analyte sensing composition and methods for making and using such sensors. Illustrative embodiments include electrochemical glucose sensors having glucose oxidase coatings.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: October 12, 2010
    Assignee: Medtronic MiniMed, Inc.
    Inventors: Rajiv Shah, Gopikrishnan Soundararajan, Rebecca K. Gottlieb, Udo Hoss, Eric A. Grovender, Shaun M. Pendo
  • Patent number: 7809441
    Abstract: In an embodiment, the invention includes an implantable medical device with a pulse generator and a chemical sensor in communication with the pulse generator, the chemical sensor configured to detect an ion concentration in a bodily fluid. In an embodiment, the invention includes a method for providing cardiac arrhythmia therapy to a patient including sensing a physiological concentration of an analyte, communicating data regarding the physiological concentration of the analyte to an implanted pulse generator, and delivering therapy to the patient based in part on the physiological concentration of the ion. In an embodiment, the invention includes a method for monitoring diuretic therapy. In an embodiment, the invention includes a method for controlling delivery of an active agent into a human body. Other aspects and embodiments are provided herein.
    Type: Grant
    Filed: May 17, 2006
    Date of Patent: October 5, 2010
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Michael John Kane, Jeffrey Allen Von Arx, James Gregory Bentsen, Jonathan Kwok
  • Patent number: 7736310
    Abstract: Devices and methods for maintaining a medical device on-body are provided. Embodiments include medical device securement systems having first and second on-body securement elements. Also provided are systems and kits for use maintaining a medical device on-body.
    Type: Grant
    Filed: January 30, 2006
    Date of Patent: June 15, 2010
    Assignee: Abbott Diabetes Care Inc.
    Inventor: Marc B. Taub
  • Patent number: 7729737
    Abstract: Embodiments of the present invention provide for raising a background current setting for a biosensor above the actual (measured) background current present (i.e., overestimating the background current), particularly in the hypoglycemic range, to improve sensor accuracy and decrease the chance of glucose value overestimation by the sensor.
    Type: Grant
    Filed: November 14, 2006
    Date of Patent: June 1, 2010
    Assignee: ISense Corporation
    Inventor: W. Kenneth Ward
  • Patent number: 7630747
    Abstract: An apparatus for use with a patient having a vessel carrying blood to ascertain characteristics of the blood. The apparatus includes a display module and a probe having a distal extremity adapted to be inserted into the vessel of the patient and having a proximal extremity coupled to the display module. The probe includes a sensor in the distal extremity for providing an electrical signal to the display module when the probe is disposed in the blood. The probe can have an antithrombogenic surface treatment for inhibiting the adhesion of blood components to the probe when disposed in the blood.
    Type: Grant
    Filed: September 9, 2003
    Date of Patent: December 8, 2009
    Assignee: Keimar, Inc.
    Inventors: Paul D. Corl, Harry D. Nguyen, Amos Gottlieb, Margaret R. Webber
  • Publication number: 20090281405
    Abstract: An iontophoretic sampling device for non-invasively determining the relative levels of two substances present in a biological system.
    Type: Application
    Filed: May 29, 2009
    Publication date: November 12, 2009
    Inventors: Richard Henry GUY, Maria Begona DELGADO-CHARRO
  • Publication number: 20090030293
    Abstract: A sensing device, apparatus and system, and method for operating the same are provided. The sensing apparatus includes a first module and a second module. The first module includes a controller, a transmitter and an array of sensor elements. The controller is capable of activating one or more sensor elements in the array independently of others in the array, in order to obtain a sensor output from the array at different times by using different sensor elements in said array. The transmitter is configured to transmit sensor data derived from the sensor output from the first module to a receiver of the second module. Each sensor element is a biological sensor for detecting the presence of the same analyte in the environment in which the sensor array is to be deployed.
    Type: Application
    Filed: February 10, 2006
    Publication date: January 29, 2009
    Applicant: The University Court of the University of Glasgow
    Inventors: Jonathan Mark Cooper, David Robert Sime Cumming, Nicholas Wood, Lei Wang
  • Publication number: 20080161665
    Abstract: Devices and methods for measuring a target ion concentration uses an electrode pair. The pair includes a working electrode and a reference electrode. The working and reference electrodes are ion-selective electrodes (ISEs). The reference ISE can include a sodium ISE. The ISE pair interacts with body fluids where a target ion concentration changes more than sodium ion concentration over time. Some ISE membranes of a pair vary essentially only in the ionophore. An ISE pair can determine the ratio of a target ion concentration to sodium ion concentration in vivo. Periodic measurement of sodium concentration in drawn blood can be used to calibrate an ISE pair and provide target ion concentration as an output. Or, a potassium/sodium ISE pair beneficially monitors potassium concentration changes over time in heart- or kidney-failure patients. Then, manual or automatic titration of a diuretic material can be implemented to maintain a desired potassium concentration.
    Type: Application
    Filed: February 21, 2008
    Publication date: July 3, 2008
    Inventor: QINGSHAN YE
  • Patent number: 7389132
    Abstract: The present invention mainly relates to a method and apparatus for measuring the concentration of a solute in a solvent. Disclosed is an apparatus or method for determining the concentration of a solute in a solvent of a solution in a container having a time-varying volume by analyzing two signals received from the solution, comprising: measuring the quantity of the two received signals, converting the two signals into two electro-optical or electrical signals, performing a mathematical transformation on the two electro-optical or electrical signals, and determining the ratio of the transformation components of the two electro-optical or electrical signals. The present invention can be used in various applications of determining the ingredient concentration of a fluid, such as a gas or liquid. Particularly, the present invention finds applications in blood analysis in a human body for measuring, for example, the glucose, triglycerol, cholesterol, or oxyhemoglobin concentrations of the blood.
    Type: Grant
    Filed: January 6, 2004
    Date of Patent: June 17, 2008
    Inventors: Wei-Kung Wang, Gin-Chung Wang
  • Patent number: 7383072
    Abstract: A method of sensing the concentration level of at least one particular electrolyte in the sweat fluid of a subject, includes providing a sweat sensor system having sweat fluid absorbing material, measuring apparatus for sensing the electrical conductivity of sweat fluid absorbed by the absorbing material and producing ionic concentration data for said at least one particular electrolyte, and a user interface connected to the measurement apparatus for interpreting the data to a user. The absorbing material is applied to the skin of the subject to cause sweat fluid thereon to be absorbed by the absorbing material whereby the measurement apparatus produces ionic concentration data for the sweat fluid absorbed and the user interface interprets the data for a user.
    Type: Grant
    Filed: May 9, 2005
    Date of Patent: June 3, 2008
    Assignee: P. J. Edmonson Ltd
    Inventors: Peter J. Edmonson, Douglas W. Stoddard
  • Patent number: 7383071
    Abstract: One embodiment is a microprobe. An example of the microprobe comprises a housing having an aperture. This example of the microprobe also comprises an ISFET attached to the housing. The ISFET may have a gate located proximate the aperture. This example of the microprobe further comprises a reference electrode attached to the housing proximate the aperture. Another embodiment is a microsensor system. Another embodiment is a method for measuring a characteristic of tissue. Yet another condition embodiment is a method for monitoring tissue pH.
    Type: Grant
    Filed: January 20, 2004
    Date of Patent: June 3, 2008
    Assignee: United States of America as represented by the Secretary of the Navy
    Inventors: Stephen D. Russell, Paul R. de la Houssaye, Jamie K. Pugh, William Pugh, Dennis E. Amundson, Howard W. Walker
  • Patent number: 7373195
    Abstract: Devices and methods for measuring a target ion concentration uses an electrode pair. The pair includes a working electrode and a reference electrode. The working and reference electrodes are ion-selective electrodes (ISEs). The reference ISE can include a sodium ISE. The ISE pair interacts with body fluids where a target ion concentration changes more than sodium ion concentration over time. Some ISE membranes of a pair vary essentially only in the ionophore. An ISE pair can determine the ratio of a target ion concentration to sodium ion concentration in vivo. Periodic measurement of sodium concentration in drawn blood can be used to calibrate an ISE pair and provide target ion concentration as an output. Or, a potassium/sodium ISE pair beneficially monitors potassium concentration changes over time in heart- or kidney-failure patients. Then, manual or automatic titration of a diuretic material can be implemented to maintain a desired potassium concentration.
    Type: Grant
    Filed: July 30, 2004
    Date of Patent: May 13, 2008
    Assignee: Medtronic, Inc.
    Inventor: Qingshan Ye
  • Patent number: 7231242
    Abstract: A method for measuring and determining urea level in human blood by reverse iontophoresis comprising the following steps of: placing an anode electrode on skin, placing a container comprising a solution including urease and a cathode electrode on skin, applying electric current to the anode electrode and the cathode electrode so that an electrical circuit is established there between, whereby urea molecules migrate from blood into the container, determining the urea level in the blood by the changes in the pH of the urease solution.
    Type: Grant
    Filed: April 8, 2003
    Date of Patent: June 12, 2007
    Inventors: Tuncer Degim, Sibel Ilbasmis, Zelihagul Degim, Rusen Dundaroz, Metin Denli
  • Publication number: 20040138544
    Abstract: A rapid response, single use analyte sensor, adapted to measure an analyte concentration in body fluid. The sensor includes a lancet and a body fluid trapping structure, adapted to trap body fluid on the skin. An electrochemical analyte measurement system measures the analyte concentration in the body fluid that is trapped on the surface of the skin, by the body fluid trapping structure. In one preferred embodiment, the body fluid trapping structure defines an interior volume of only 30 nanoliters of body fluid.
    Type: Application
    Filed: February 27, 2003
    Publication date: July 15, 2004
    Inventors: W. Kenneth Ward, Richard G. Sass, Mark Neinast, Ellen Anderson, Lawrence B. Jansen
  • Patent number: 6701341
    Abstract: An ultrasound information processing system is disclosed in which ultrasound image data is packetized into ultrasound information packets and routed to one or more of a plurality of processors for performing image processing operations on the ultrasound image data, the ultrasound information packets being routed according to entries in a host-programmable routing table. A common distribution bus is coupled between packetizing circuitry and dedicated input buffers corresponding to each processor for distributing the ultrasound information packets, and a common output bus to is used to transfer processed image data from the processors to an output device. The disclosed ultrasound information processing system architecture allows for a high throughput rate for accommodating real-time image processing operations, while also allowing for ready programmability and upgradability.
    Type: Grant
    Filed: November 24, 1999
    Date of Patent: March 2, 2004
    Assignee: U-Systems, Inc.
    Inventors: Anthony Wu, Shengtz Lin, Ali Moayer, Pin Yu
  • Patent number: 6616614
    Abstract: Apparatus for ascertaining cardiac output of the heart of a patient comprising a control and display module. A venous probe is inserted into a vein in the forearm of the patient and is coupled into the control and display module and provides an electrical signal representing the dissolved oxygen in the venous blood. An arterial probe is inserted into an artery in the forearm of the patient and is coupled into the control and display module and provides an electrical output signal representing the dissolved oxygen in the arterial blood. The control and display module has a visible display that provides a continuous in vivo cardiac output that utilizes an arterial venous oxygen differential equation which includes an adjustment factor for adjusting for venous blood being sampled rather than mixed venous blood in the pulmonary artery of the patient.
    Type: Grant
    Filed: September 18, 2001
    Date of Patent: September 9, 2003
    Assignee: Keimar Corporation
    Inventors: Margaret R. Webber, Jeffrey J. Christian, Harry D. Nguyen, Vladimir J. Drbal
  • Publication number: 20020128589
    Abstract: Epilepsy and other neurological disorders that are affected by the electrical potential difference between intracellular fluid and extra-cellular fluid and therefore the cell membrane potentials, and therefore the thresholds for the communication between brain cells can be controlled by re-circulating extra-cellular brain fluid after the fluid has been treated to alter its ion concentrations. A computer-controlled pump can precisely control the extraction and delivery of brain fluid after the ion concentration of the fluid is appropriately adjusted, e.g. guided by the Goldmann equation. Well-known techniques for modifying ion concentrations can be used to raise or lower ion concentrations as needed.
    Type: Application
    Filed: May 8, 2002
    Publication date: September 12, 2002
    Applicant: Medtronic, Inc.
    Inventors: Johan F.M. Gijsbers, Frans L.H. Gielen
  • Patent number: 6411834
    Abstract: An annul protecting portion 23 having a thickness larger than the thickness of a sensor sensitive portion 1 is provided in such a manner as to surround the sensor sensitive portion 1, the sensor sensitive portion 1 together with the protecting portion 23 is placed between living tissues, so as to ensure that the gate portion 7 is not subjected to an external pressure by coming into contact with the living tissues. Further, outer peripheries of lead wires 4 on the sensor sensitive portion 1 side are covered with a plasticity material 24 woven into a tubular shape by a metal wire such as a stainless steel wire, and is grounded together with the metallic protecting portion, so as not to be subjected to induction noise. Further, the metal wire is bent to hold the sensor sensitive portion 1 at a suitable angle.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: June 25, 2002
    Assignee: Nihon Kohden Corporation
    Inventor: Yuko Nagai
  • Publication number: 20010037099
    Abstract: The present invention concerns a system for determining the concentration of at least one analyte in a body fluid. The system has a first member and at least a second member of which at least one has a recess on its surface and the members are joined together in such a manner that the recess is closed by a surface of the other member to form a channel. The first and/or second member is composed at least partially of a membrane which is located either in the region of the recess or on the part of the other member that is opposite to the recess such that substances can be taken up from the surrounding fluid by means of the membrane. The system additionally has a sensor which can be used to determine the concentration of an analyte in the channel. Furthermore the system has at least one integrated reservoir which is connected to the channel.
    Type: Application
    Filed: February 27, 2001
    Publication date: November 1, 2001
    Inventor: Carlo Effenhauser
  • Publication number: 20010005774
    Abstract: An automatic electrophysiological measuring apparatus to automatically penetrate a glass electrode(s) into the membrane of a Xenopus Oocyte to hold the membrane potential and to automatically measure reactions to the administration of a medicine is to be provided.
    Type: Application
    Filed: December 21, 2000
    Publication date: June 28, 2001
    Inventors: Hirokazu Kato, Jun Otomo, Sayuri Nomura, Tomoko Takeshita, Sakae Saito, Shokichi Matsunami, Noboru Moriya