Abstract: Embodiments of the present invention include a system having at least one sensor configured to monitor a muscle oxygen saturation (SmO2) level of a patient who is undergoing cardiac arrest and to generate a signal representing SmO2 level; a user interface device; a processor communicably coupled to the user interface device, the processor configured to cause the user interface device to present an array of two or more possible nodes of a clinical decision support tree, wherein at least one of the nodes indicates cardiopulmonary resuscitation (CPR) treatment of the patient with no ventilation, and wherein at least another of the nodes indicates CPR treatment of the patient with active ventilation; determine which of the two or more possible nodes should be emphasized based on the SmO2 level; and update the array of the two or more possible nodes based on the determination.

Abstract: A monitoring system for cardiac operations with cardiopulmonary bypass comprising: a processor operatively connected to a heart-lung machine; a pump flow detecting device connected to a pump of the heart-lung machine to continuously measure the pump flow value and send it to the processor; a hematocrit reading device inserted inside the arterial or venous line of the heart-lung machine to continuously measure the blood hematocrit value and to send it to the processor; a data input device to allow the operator to manually input data regarding the arterial oxygen saturation and the arterial oxygen tension; computing means integrated in the processor to compute the oxygen delivery value on the basis of the measured pump flow, the measured hematocrit value, the preset value of arterial oxygen saturation, and the preset value of arterial oxygen tension; and a display connected to the processor to display in real-time the computed oxygen delivery value.

Abstract: Methods and systems are provided for using time-frequency warping to analyze a physiological signal. One embodiment includes applying a warping operator to the physiological signal based on the energy density of the signal. The warped physiological signal may be analyzed to determine whether non-physiological signal components are present. Further, the same warping operator may be applied to signal quality indicators, and the warped physiological signal may be analyzed based on the warped signal quality indicators. Non-physiological signal components, or types of non-physiological noise sources, may be identified based on a comparison of the physiological signal with the signal quality indicators. Non-physiological signal components may also be identified based on a neural network of known noise functions. In some embodiments, the non-physiological signal components may be removed to increase accuracy in estimating physiological parameters.

Abstract: A physiological monitor device includes a central processing unit (CPU) that is configured to control operation of the device, a display screen, and one or more computer readable data storage media storing software instructions that, when executed by the CPU, cause the device to: create or modify a patient profile, select a patient test, store one or more test parameters selected or entered for the patient test, store one or more thresholds selected or entered for at least one of the test parameters, store one or more instructions for the patient, start the test, display test results while the test is in progress, determine whether any of the test parameters exceed limits set by the one or more thresholds, take one or more actions when it is determined that one or more of the test parameters exceed the limits set by the one or more thresholds, provide a summary and analysis of the test results, and send the test results to a computing device.

Abstract: Sensor designs or shapes to facilitate the placement of sensors on a patient are provided. For example, a first sensor may include a sensor body having a keyed interface region that is configured to align with a complementary keyed interface region of second sensor. Such sensors may also include various features to further facilitate the positioning of the sensors on the patient tissue and the positioning of the sensors with respect to one another. For example, the first sensor may include indicia relating to the second sensor having the complementary keyed interface region.

Abstract: The present invention provides devices and methods for calculating and monitoring oxygenation parameters during treatment with delivery of nitric oxide. The devices and methods of the present invention can calculate the oxygenation index based on measurements of mean airway pressure, saturation of oxygen and fraction of inspired oxygen derived from components of the present invention. Also described is a nitric oxide delivery device that incorporates a proximal pressure transducer.

Abstract: A health care medical device includes one or more medical sensor devices, an assembly that houses the one or more medical sensor devices and a mobile electronic computing device with a display. The mobile electronic computing device is secured to the assembly. Medical data from the one or more medical sensor devices is transmitted to the mobile electronic computing device.

Abstract: Present embodiments are directed to a system and method capable of detecting and graphically indicating physiologic patterns in patient data. For example, present embodiments may include a monitoring system that includes a monitor capable of receiving input relating to patient physiological parameters and storing historical data related to the parameters. Additionally, the monitoring system may include a screen capable of displaying the historical data corresponding to the patient physiological parameters. Further, the monitoring system may include a pattern detection feature capable of analyzing the historical data to detect a physiologic pattern in a segment of the historical data and capable of initiating a graphical indication of the segment on the screen when the physiologic pattern is present in the segment.

Abstract: A system and method for monitoring and notification of injury wherein an individual wears a monitoring device, the monitoring device tracks biometric data such as blood oxygen levels, heart rate, and acceleration of the individual and sends the data to a base station, the base station analyzes the data to see if bodily changes such as decreased blood oxygen levels or significant changes in heart rate or acceleration has occurred, and the base station determines whether to sound an alarm to indicate death or severe bodily injury.

Abstract: Patient mobile computing system (1) and method for predicting exacerbations in a patient illness related status, the method includes collecting patient sensor data using sensors (8), and executing a local prediction model. The local prediction model includes a Bayesian network (6) to obtain a probability of an exacerbation of a patient status. The Bayesian network (6) receives patient input data, patient sensor data, and providing probability data, and the local prediction model provides guidance data based on the probability data. The local prediction model (6) is implemented both in a portable device (1), such as a smart phone, and in a centralized patient data processing system (20).

Abstract: A monitoring system includes a wearable eyeglass, band, belt, patch or bandage appliance; and a processor coupled to the wearable eyeglass, band, belt, patch or bandage appliance to analyze vital data or wellness data.

Abstract: Described herein are technologies related to a wireless electronic vital sign monitoring of a person. More particularly, detecting vital signs and processing of the detected vital signs using a bio monitoring patch.

Abstract: Apparatus is provided, including a sensor, adapted to generate a sensor signal indicative of biorhythmic activity of a user of the apparatus, the sensor signal having a first characteristic, indicative of a voluntary action of the user, and a second characteristic, indicative of a benefit-related variable of the user. The apparatus also includes a control unit, adapted to receive the sensor signal, and, responsive to the second characteristics generate an output signal which directs the user to modify a parameter of the voluntary action indicated by the first characteristic.

Abstract: The disclosed embodiments relate to a system and method for assuring validity of monitoring parameters in combination with a therapeutic device. An exemplary embodiment of the present technique comprises perturbing a treatment administered to a patient, measuring at least one parameter of the patient reflecting the underlying physiological state and associated with the treatment, and comparing the perturbations of the treatment to measurements of the at least one parameter to determine if the perturbations to the treatment are reflected by the parameter.

Abstract: Embodiments of the present invention relate to a system and method for in vivo measurement of blood parameters by processing analog electrical signals from a plurality of photodetectors. In some embodiments, it is possible to determine one or more blood parameters according to (i) a first electrical signal from a first detector and (ii) a second electrical signal from a second photodetector. A difference analog electrical signal is generated, indicative of a difference between the light response signal at the first location and light response signal at the second location, is generated. One or more blood parameters may be detected according to the difference analog electrical signal.

Abstract: A sensor chip is a sensor device for measuring a property of a substance by adsorbing the substance on a surface of the sensor chip. The sensor chip includes a diaphragm having a first surface, a second surface, and at least one through hole penetrating from the first surface to the second surface. At least a part of the first surface, the second surface, and an inner wall surface of the through hole is covered with a noncrystalline solid layer including SiOX as a main component, in which substance X is an element having higher electronegativity than that of silicon.

Abstract: Embodiments of the invention are directed to an optical sensor for detecting glucose. The sensor comprises a chemical indicator system disposed within a gap between the distal end of an optical fiber and an atraumatic tip portion, wherein the optical fiber and atraumatic tip portion are coupled by a coupling member, such as a rod or hypotube or cage that traverses the gap. The sensor further comprises a means for generating and detecting an optical reference signal unrelated to the glucose, such that ratiometric correction of glucose measurements for artifacts in the optical system is enabled.

Abstract: The present invention provides a biomedical monitoring system combining a mobile device. Signals can be transmitted between the sensing device and the mobile device via the audio interface by modulating and demodulating the audio signals or encoding and decoding the digital signals. Thereby, it can be applied extensively to mobile devices having audio jacks and thus bringing more convenience. In addition, because the mobile devices inherently have the functions of operational processes, transmission, storage, interface operations, result displaying, network connection, image extraction, and power supply, the required components in sensing devices can be simplified substantially and hence reducing the volume and the manufacturing cost.

Abstract: The invention relates to a method and device for measuring blood gas parameters, preferably pH, pCO2, and pO2, in a blood sample, where the blood sample of a patient is fed into at least one measuring cell of an analyzer. In order to obtain accurate values for the blood gas parameters even in cases where the temperature of the patient deviates from normal temperature, the temperature of the patient or blood sample is measured upon sample withdrawal, and the measured temperature is transmitted to the analyzer or is recorded by the analyzer, and the temperature of the measuring cell of the analyzer is adjusted to the measured temperature by cooling or heating.

Abstract: Methods and systems are disclosed for analyzing multiple scale bands in the scalogram of a physiological signal in order to obtain information about a physiological process. An analysis may be performed to identify multiple scale bands that are likely to contain the information sought. Each scale band may be assessed to determine a band quality, and multiple bands may be combined based on the band quality. Information about a physiological process may determined based on the combined band. In an embodiment, analyzing multiple scale bands in a scalogram arising from a wavelet transformation of a photoplethysmograph signal may yield clinically relevant information about, among other things, the blood oxygen saturation of a patient.

Abstract: Disclosed herein is a method for processing a physiological signal to measure physiological characteristics of a living organism. The method includes: (a) dividing P1?(t), which is obtained by differentiating one signal function P1(t) between two signal functions having different wavelength bands and representing the physiological characteristics of the living organism, by P2?(t) obtained by differentiating the other signal function P2(t); and (b) obtaining a constant b of the following function n1(t) and a cycle of the following function s1(t) through Math Formula 1: (P1?(t)/P2?(t))|t=t1,t2,t3, . . . =k, (where P1(t)=s1(t)+n1(t), P2(t)=s2(t)+n2(t), as1(t)=s2(t), bn1(t)=n2(t), a, b and k are constants, t is time, and n1(t) and n2(t) are signal functions due to noise when measuring the physiological signal).

Abstract: A device adapted for insertion into one or more of an esophagus, a stomach, an intestine and a colon for detecting a blood-oxygen level associated with at least one mucous membrane region in said one or more of the esophagus, the stomach, the intestine and the colon is disclosed. The device includes a flexible and elongated main body, and a blood oxygen level detecting unit. The blood oxygen level detecting unit includes one or more blood oxygen level detecting modules disposed on the main body and capable of generating one or more signals associated with the blood oxygen level(s) of one or more mucous membrane regions nearby the blood oxygen level detecting module(s).

Abstract: A data collection module receives signals generated using at least one of an electromyography (EMG) sensor connected to a user, an electroencephalography (EEG) sensor connected to the user, an electrocardiogram (ECG) sensor connected to the user, and an oxygen saturation (SPO2) sensor connected to the user. A mobile computing device is implemented independently of the data collection module and communicates with the data collection module. The mobile computing device includes a processor and a tangible computer readable medium including a sleep study application embodied as code for: selectively prompting the data collection module to store data samples generated based on the signals; receiving the data samples from the data collection module; and transmitting sleep study data including the data samples to a first data server. The mobile computing device further includes a communications module that wirelessly downloads the sleep study application from a second data server.

Abstract: A mobile computing device for performing a sleep study includes a processor, a tangible computer readable medium, and a communications module. The tangible computer readable medium includes a sleep study application embodied as code for: selectively prompting a data collection module to store data samples generated based on signals generated using at least one of an electromyography (EMG) sensor connected to a user, an electroencephalography (EEG) sensor connected to the user, an electrocardiogram (ECG) sensor connected to the user, and an oxygen saturation (SPO2) sensor connected to the user; receiving the data samples from the data collection module; and transmitting sleep study data including the data samples to a first data server. The communications module wirelessly downloads the sleep study application from a second data server.

Abstract: Electrode structures for transvascular nerve stimulation combine electrodes with an electrically-insulating backing layer. The backing layer increases the electrical impedance of electrical paths through blood in a lumen of a blood vessel and consequently increases the flow of electrical current through surrounding tissues. The electrode structures may be applied to stimulate nerves such as the phrenic, vagus, trigeminal, obturator or other nerves.

Abstract: A system for in-place visualization of sensed data is provided. The system includes a formable sheet comprising a display and sensors embedded within the sheet underneath the display. The display will display information relating to sensed data on a portion of the display corresponding to locations of the sensors located underneath the display. As a result, the display displays the information above or directly above the sensors that output data.

Abstract: Various embodiments of an tracheal tube having a sensor coupled to a selectively permeable membrane are provided. In some embodiments, the membrane may be permeable to one or more blood gases and/or blood analytes. Certain embodiments of the endotracheal tube may be capable of deploying the sensor during intubation to sense one or more indicators of blood flow characteristics, such as a level of blood gases and/or blood analytes, in the respiratory tract. Embodiments of the present invention may include positioning of the sensor in a variety of suitable positions with respect to the permeable membrane, such as mounting the sensor to the underside of an inflatable permeable membrane.

Abstract: A blood parameter measuring device and a method for measuring a blood parameter are provided. The blood parameter measuring device includes an emitted source, a receiver module, and an actuator. The emitted source is disposed at a side of a tissue to be analyzed and provides at least two different wavelengths of radiation. The receiver module is disposed at another side of the tissue to be analyzed to receive the attenuated radiation produced by the emitted source. The actuator is connected to at least one of the emitted source and the receiver module. The actuator generates a driving force to make the emitted source and the receiver module contacts the tissue to be analyzed, thereby imposing a normal stress on a surface of the tissue to be analyzed to change a wave path between the emitted source and the receiver module.

Abstract: The present invention is directed to an integrated system and a method for utilizing the system to detect and remove blood-borne factors of interest, such as pathogens and/or toxins and/or cytokines, from blood or serum (blood) by contacting the blood with a solid, essentially nonporous substrate which has been surface treated with molecules or chemical groups (the adsorbent media or media) having a binding affinity for the pathogens and/or toxins to be removed (the adsorbents). The invention can be used to remove virulence factors, e.g. toxins, that are released from various pathogens. In one aspect, the invention is for the treatment of sepsis and infection, such as infections associated with battle field trauma.

Abstract: Present embodiments are directed to a system and method capable of detecting and graphically indicating physiologic patterns in patient data. For example, present embodiments may include a monitoring system that includes a monitor capable of receiving input relating to patient physiological parameters and storing historical data related to the parameters. Additionally, the monitoring system may include a screen capable of displaying the historical data corresponding to the patient physiological parameters. Further, the monitoring system may include a pattern detection feature capable of analyzing the historical data to detect a physiologic pattern in a segment of the historical data and capable of initiating a graphical indication of the segment on the screen when the physiologic pattern is present in the segment.

Abstract: Method and apparatus for inserting at least a portion of a sensor into a patient is provided.

Abstract: The diagnostic device disclosed in this application is a device for diagnosing liver condition. The diagnostic device comprises a nitric oxide sensor and an information output unit. The nitric oxide sensor can be brought into contact with hepatocytes making up the liver and detects the concentration of nitric oxide produced by the hepatocytes. The information output unit, based on the nitric oxide concentration detected by the nitric oxide sensor, outputs information for diagnosing the condition of the liver. The information output unit can, for example, output a graph showing the change over time in the nitric oxide concentration detected by the nitric oxide sensor.

Abstract: A physiology monitoring system and a physiology monitoring method are disclosed. The physiology monitoring system includes a physiological information sensor, a data analysis device and an application service system. The physiological information sensor is suitable for sensing physiological information of a user. The data analysis device is suitable for receiving data of the physiological information from the physiological information sensor, calculating a plurality of data features of the data, determining whether each data feature has an alert condition event, calculating occurrence probabilities of a plurality of critical condition events or a plurality of physiology condition events by using the corresponding alert condition event or events, and determining a critical condition or a physiology condition of the user according to the occurrence probabilities. The application service system can provide the user with a service according to the critical condition or a physiology condition of the user.

Abstract: The present invention relates to a mobile terminal with a health care function and a method of controlling the mobile terminal. An embodiment of the present invention relates to a mobile terminal with a health care function. The mobile terminal includes a sensing unit that senses a living body signal from a user and information on user's surroundings when performing the health care function, a controller that generates a numerically-valued living body information using the living body signal, sets a reference range of numerical values using the information on the user's surroundings and generates alerting information depending on whether or not a numerical value of the living body information falls into the reference range of numerical values, and a display unit that displays the alerting information under the control of the controller.

Abstract: A detection device for detecting a blood count parameter in a blood vessel, comprising a transmitter having a number of transmit antennas for transmitting at least one transmit signal, a receiver having a number of receive antennas for receiving at least one receive signal, a processor to select a detection configuration comprising one of the transmit antennas and one of the receive antennas and select a second detection configuration comprising one of the transmit antennas and one of the receive antennas, and a loss detector that is designed, when the first detection configuration is selected to transmit a transmit signal, to detect a first loss value on the basis of the transmit signal and a receive signal, and, when the second detection configuration is selected to transmit a transmit signal, detect a second loss value on the basis of the transmit signal and a receive signal. The processor is designed to select the detection configuration having the lower loss value to detect the blood count parameter.

Abstract: The present disclosure relates generally to patient monitoring systems and, more particularly, to signal analysis for patient monitoring systems. In one embodiment, a method of analyzing a detector signal of a physiological patient sensor includes obtaining the detector signal from the physiological patient sensor, and determining a ratio of the signal between two or more channels. A distribution of the angles between the points of the ratio over time may be used to determine a true ratio or a ratio of ratios for use in the determination of a physiological parameter.

Abstract: Various embodiments of an tracheal tube having a sensor coupled to a selectively permeable membrane are provided. In some embodiments, the membrane may be permeable to one or more blood gases and/or blood analytes. Certain embodiments of the endotracheal tube may be capable of deploying the sensor during intubation to sense one or more indicators of blood flow characteristics, such as a level of blood gases and/or blood analytes, in the respiratory tract. Embodiments of the present invention may include positioning of the sensor in a variety of suitable positions with respect to the permeable membrane, such as mounting the sensor to the underside of an inflatable permeable membrane.

Abstract: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system.

Abstract: In one embodiment, measuring mitochondrial capacity includes performing arterial occlusions on a patient, measuring oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin within the patient's body during the occlusions, calculating a blood volume correction factor that accounts for a change in blood volume that occurs during the arterial occlusions, and applying the correction factor to the measured oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin measurements to obtain correct oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin measurements.

Abstract: The presently disclosed subject matter relates to sensors for measuring an amount of a gaseous species in a sample. The sensors comprise a gas permeable polysiloxane network membrane, comprising both alkyl and fluorinated alkyl groups. In some embodiments, the polysiloxane network can be formed from the co-condensation of a mixture of an alkylalkoxysilane and a fluorosilane. The presently disclosed subject matter also relates to methods of making the sensors, methods of selectively measuring an amount of a gaseous species, such as nitric oxide, in a sample, and to compositions comprising the polysiloxane networks.

Abstract: An apparatus and method for easily and accurately measuring a biological signal by using a wristwatch-type measurement module. After a band of the wristwatch-type measurement module is tightened to wear on a user's wrist, the band is further tightened to make the wristwatch-type measurement module closely contact the user's wrist. An operation mode of the wristwatch-type measurement module closely contacting the user's wrist is switched from a normal mode to a measurement mode, and a user's biological signal is measured from the user's wrist through the wristwatch-type measurement module in the measurement mode. The user's biological signal is then displayed through the wristwatch-type measurement module.

Abstract: A system including a plurality of wireless sensors for monitoring one or more parameters of a subject is provided. The wireless sensors can be attachable to or implantable in the subject and form a network. The sensors can include a sensing component configured to detect a signal corresponding to at least one condition of the subject. The sensors further can include a communication component configured to wirelessly transmit the detected signal to at least another of the plurality of wireless sensors, and wirelessly receive a signal transmitted from at least one of the remaining sensors in the network.

Abstract: A transdermal test sensor assembly adapted to determine an analyte concentration of a fluid sample is disclosed. The assembly comprises a sensor support including at least one reservoir adapted to hold a liquid. The assembly further comprises a test sensor being coupled to the sensor support. The test sensor forms at least one aperture therein. At least a portion of the at least one aperture is adjacent to the at least one reservoir. The assembly further comprises a hydrogel composition positioned on the test sensor. The hydrogel composition is linked to the at least one reservoir via the at least one aperture.

Abstract: Medical sensing devices and systems that transmit digital data from a first device via an ultrasonic digital modem to a receiver such as a smartphone. Methods of transmitting digital biological data by ultrasound are also described.

Abstract: A tissue-implantable sensor for measurement of solutes in fluids and gases, such as oxygen and glucose, is provided. The sensor includes: i) a detector array including at least one detector; ii) a telemetry transmission portal; iii) an electrical power source; and iv) circuitry electrically connected to the detector array including signal processing means for determining an analyte level, such as glucose level, in a body fluid contacting the detectors. The sensor components are disposed in a hermetically sealed housing having a size and shape suitable for comfortable, safe, and unobtrusive subcutaneous implantation allowing for in vivo detection and long term monitoring of tissue glucose concentrations by wireless telemetry.

Abstract: An ischemia detecting system has an implantable medical device connectable to an LV cardiac catheter with sensors for generating sensor signals representative of the concentration of a constituent in coronary venous blood at different sites in the coronary venous system. The sensor signals are co-processed by the system to detect an ischemic region of the subject's heart based on a relation between the sensor signals. The detection of the particular ischemic cardiac region is possible by conducting the concentration monitoring on either sides of a branching vein in the coronary venous system and co-processing the sensor signals.

Abstract: A method and apparatus for determining the presence or absence of a pulmonary embolism (PE) in a patient. The breathing gas CO2 partial pressure (PCO2) during the expiration of breathing gases by the patient, the end tidal (EtCO2), CO2 partial pressure, and the CO2 partial pressure (PaCO2) of the blood are measured. The volume (V) of breathing gases expired during the expiration of breathing gases by the patient is also measured and a relationship between changes in breathing gas CO2 partial pressure (PCO2) and changes in breathing gas volume (V) in an alveolar expiration phase of patient expiration is determined. The difference between the blood CO2 partial pressure (PaCO2) and the end expiration CO2 partial pressure is divided by the relationship between PCO2 and V produce a quantity which is compared to a threshold value. If the quantity is below the threshold value, the absence of a pulmonary embolism is indicated.

Abstract: A method and system establishing cryptographic communications between a remote device and a medical device, with the medical device having less processing power than the remote device are disclosed. The method may comprise establishing unencrypted communication between the remote device and the medical device, generating an asymmetric key pair by the remote device comprising a public key and a private key, generating a key request message and sending of the key request message together with the public key to the medical device, generating a pre-master key and encryption of the pre-master key with the received public key by the medical device, generating a key response message and sending of the key response message together with the encrypted pre-master key from the medical device to the remote device, decrypting the encrypted pre-master key with the private key by the remote device, and deriving a master key as a symmetric key from the pre-master key.

Abstract: Embodiments of the invention are directed to an optical sensor for detecting blood glucose. The sensor comprises a chemical indicator system disposed within a gap between the distal end of an optical fiber and an atraumatic tip portion, wherein the optical fiber and atraumatic tip portion are coupled by a coupling member, such as a rod or hypotube or cage that traverses the gap. The sensor further comprises a means for generating and detecting an optical reference signal unrelated to the blood glucose, such that ratiometric correction of blood glucose measurements for artifacts in the optical system is enabled.

Abstract: In some embodiments, a cardiac monitoring system includes multiple sensors configured for implantation in a cardiovascular system of a user. Each sensor includes a sensing unit configured to be disposed in sensory communication with the location for measuring a biological parameter in the at least one heart chamber. The sensing unit is also configured to generate a sensory signal associated with the biological parameter. Each sensor also includes a wireless transceiver configured to receive the sensory signal from the sensing unit. The wireless transceiver is further configured to wirelessly transmit the sensory signal to an external processing device disposed outside a body of the user. The external processing device monitors, based on the sensory signal received from at least two sensors from the plurality of sensors, cardiac health associated with at least one of an implanted device or a surgery.