Abstract: Disclosed herein are devices, methods and systems for monitoring and detection of adverse events in a subject. In an embodiment, an insulin delivery device includes an insulin injection device in communication with a controller for controlling the insulin injection device. The controller is configured to receive a heart signal from one or more heart sensors, and a blood glucose signal from one or more blood glucose sensors. The controller is further configured to analyze changes in the heart rhythm of the subject based on the heart signal and determine, based on the changes in the heart rhythm and the blood glucose signal, whether the subject is and/or will be experiencing an adverse event. Upon determination that the subject is or will be experiencing an adverse event, the controller determines one or more parameters of delivery of insulin to be delivered to the subject.

Abstract: A bio-electrode composition includes (A) an ionic material and (B) a lithium titanate powder. The component (A) is a polymer compound containing a repeating unit-a having a structure selected from an ammonium salt, a sodium salt, a potassium salt, and a silver salt of any of fluorosulfonic acid, fluorosulfonimide, and N-carbonyl-fluorosulfonamide. Thus, the present invention provides a bio-electrode composition capable of forming a living body contact layer for a bio-electrode that is excellent in electric conductivity and biocompatibility, is light-weight, can be manufactured at low cost, and can control significant reduction in the electric conductivity even when the bio-electrode is wetted with water or dried; a bio-electrode including a living body contact layer formed of the bio-electrode composition; and a method for manufacturing the bio-electrode.

Abstract: Devices, systems and methods are disclosed for treating or preventing an autism spectrum disorder, a pervasive developmental disorder, or a disorder of psychological development. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve. The nerve stimulation may be used as a behavior conditioning tool, by producing euphoria in an autistic individual. Vagus nerve stimulation is also used to modulate circulating serotonin levels in a pregnant woman so as to reduce the risk of having an autistic child; modulate the levels of growth factors within a child; promote balance of neuronal excitation/inhibition; modulate the activity of abnormal resting state neuronal networks; increase respiratory sinus arrhythmia; and avert episodes of motor stereotypies with the aid of forecasting methods.

Abstract: Monitoring muscle data can include one or more fully flexible sensor patches having sensor modules configured to sense muscle data, data processing modules, transmitter modules configured to transmit the muscle data, and a microcontroller configured to control the modules on one patch side and an adhesive layer on the other patch side; a wearable mobile hub having one or more of a receiver, transmitter, and/or transceiver module configured to be operably coupled with the one or more sensor patches so as to receive muscle data therefrom and a muscle data processing unit configured to process the received muscle data, and one or more user feedback interfaces to provide processed muscle data to the one or more user feedback interfaces; and a base station configured for receiving, storing, and analyzing the muscle data for one subject received from the mobile hub in comparison with one or more other subjects.

Abstract: Neuromodulation electrodes and related methods to treat pelvic floor disorders, such as urinary and/or faecal incontinence, using electrical stimulation of the left and/or right branches of the dorsal genital nerves, or pudendal nerve, using a highly flexible electrode unit to obtain stable and comfortable contact with the cutaneous tissue or mucous membrane at or near the glans of the clitoris, in close proximity of the targeted nerve, for stabile neuromodulation applications.

Abstract: Electrode carrier for electrophysiological measurements, including a flexible substrate, a plurality of contact pads attached to a substrate surface, wherein each contact pad includes conductive means for accommodating an electrode for electrophysiological measurement, first connecting means attached to the substrate for communicatively connecting the contact pads to a signal processing device. The first connecting means includes a plurality of conductive tracks on the substrate surface for electrically connecting the plurality of contact pads, wherein each conductive track corresponds to at least one contact pad. The substrate has at least two inextendible sections for accommodating the contact pads, wherein the sections interconnected by an extendible section. Each extendible section comprises at least one warpable member of flexible material. At least one of the warpable members accommodates at least one of the conductive tracks.

Abstract: A physical quantity measurement device that measures a physical quantity of a fluid includes a bypass flow channel through which a fluid flows, a physical quantity detection unit for detecting a physical quantity of the fluid in the bypass flow channel, a detection unit having a detection terminal electrically connected to the physical quantity detection unit, a housing having a flow channel forming portion having an insulating property and forming a bypass flow channel and a terminal accommodating portion having an insulating property and accommodating a detection terminal, and a ground portion connecting the flow channel forming portion to a ground. A volume resistivity of the flow channel forming portion is included in the range of 1.0×1011 (1.0×10 to the 11th power) ?cm to 1.0×1014 (1.0×10 to the 14th power) ?cm.

Abstract: An electrode patch for use with an external medical device, the electrode patch comprising: a first surface configured to be attached to a skin of a patient monitored by the external medical device, and an indicating mechanism disposed on the electrode patch and configured to indicate an end of a predetermined lifespan of the electrode patch.

Abstract: A method of measuring bioelectric signals of a patient having an axis extending from the patient's head to the patient's feet includes attaching a patch to the patient's skin. The patch may include a first electrode and a second electrode spaced apart along a longitudinal axis of the patch. The patch may be attached such that the longitudinal axis of the patch is generally aligned with the axis of the patient. The method may also include attaching a third electrode to the patient's skin, and measuring bioelectric signals of the patient using the first electrode, the second electrode, and the third electrode.

Abstract: An active sheath for a recognition probe of a handheld cancer screening device, in which the conductors and circuits are applied on the surface of the sheath such as in the form of a flexible circuit made of a biocompatible material and a flexible conductor or a conductive ink in the surface of the disposable cover's tip without the need to embed the electrodes or other components inside the plastic cover.

Abstract: A system and method for providing a flexible electrocardiogram (ECG) pad structure have been disclosed. In a first aspect, the system is the flexible ECG pad structure and comprises a copper layer and a paste trace layer coupled to the copper layer via a cover. In a second aspect, the method comprises providing a copper layer and coupling a paste trace layer to the copper layer via a cover.

Abstract: An emergency cardiac and electrocardiogram (ECG) electrode placement device is disclosed herein. The emergency cardiac and electrocardiogram (ECG) electrode placement device incorporates electrical conducting materials and elastic material into a pad that is applied to a chest wall of a patient, which places multiple electrodes in the appropriate anatomic locations on the patient to quickly obtain an ECG in a pre-hospital setting.

Abstract: The present invention is directed to a physiological recording device, or other types of sensors to detect a biopotential, and more particularly, a physiological recording electrode that can be used without skin preparation or the use of electrolytic gels. The invention is further directed to the configurations of structures on the physiological recording electrode's lower surface. The structures having a length, width, and height, which are capable, at least in part, of transmitting an electric potential from the skin which can be measured. The structures may or may not limit the depth of application, and/or anchor the electrode or other device during normal application, and/or allow for uniform application of the electrode or other device over unprepared skin.

Abstract: A silver chloride paste contains: a binder resin; and supported silver chloride that includes (i) a support and (ii) silver chloride supported on the support. The binder resin is, for example, a polyester resin. The support is, for example, silica.

Abstract: Embodiments relate to forming nanoporous contacts on a receiving substrate without using a seed layer on the receiving substrate. The nanoporous contacts can be used to create bonds between electronic components and the receiving substrate. To form the contacts, a photoresist mask is created on the receiving substrate by a photolithographic process. Through a sputtering process, portions of co-alloy on a depositing substrate are transferred to the receiving substrate with the photoresist mask. The photoresist mask is removed from the receiving substrate. The remaining co-alloy portions on the receiving substrate undergo a de-alloying process to form an array of nanoporous contacts.

Abstract: The present invention relates to a physiological monitoring device. Some embodiments of the invention allow for long-term monitoring of physiological signals. Further embodiments may also allow for the monitoring of secondary signals such as motion.

Abstract: The present invention relates to a physiological monitoring device. Some embodiments of the invention allow for long-term monitoring of physiological signals. Further embodiments may also allow for the monitoring of secondary signals such as motion.

Abstract: A bipolar cardiac lead (100) is provided and includes a connector pin (112), a connector insulator (116), and a ring connector (130). The connector pin (112) has a proximal end and a distal end, and the proximal end is configured to engage an electrical stimulation device. The connector insulator (116) is coupled to the distal end of the connector pin (112) and may define a bore (118) configured for receiving a portion of the connector pin (112). The connector insulator (116) provides electrical insulation between the connector pin (112) and the ring connector (130). The ring connector (130) is coupled to the connector insulator (116) with a snap-fit connection and may be disposed around a portion of the connector insulator (116). The bipolar cardiac lead (100) may be an active or a passive lead.

Abstract: An electrocardiograph measures an electrocardiac signal by processing electric signals detected by bioelectrode pads. The bioelectrode pads each includes a plurality of sheets of electrodes disposed by being stacked on each other; conductive gel sheets disposed alternately with the sheets of electrodes and interposed between the electrodes; and a dynamic pressure stabilizing plate. The electrocardiograph includes a first differential circuit for obtaining an electrocardiac source signal by taking the difference between signals each obtained from any one of the electrodes of each of two bioelectrode pads; a second differential circuit for obtaining a body motion noise signal by taking the difference between signals obtained from any two of the electrodes of each of said two bioelectrode pads; and a body motion noise removing circuit for removing the low frequency components of the body motion noise signal of each of said two bioelectrode pads from the electrocardiac source signal.

Abstract: An epoxy sealant confined around a transition seal body system for a down hole electric cable transition from a protected cable to separate conductors of a three-phase electrical service provides a vapor and pressure seal, preventing premature failure from temperature and pressure changes in the wellbore. The use of epoxy to completely surround the transition seal body within the penetrator mandrel permits field installation of continuous electrical conductors from a wellbore through a pressure sealing wellhead to the surface.

Abstract: Medical leads include a lumen body at an end of the lead, and the lumen body includes multiple filar lumens. The lumen body is joined to a lead body, and electrical connectors are longitudinally spaced along the lumen body. Filars within the filar lumens are directed through filar passageways within the lumen body to attach to the electrical connectors on the lumen body. The filar passageways may be aligned with the filar lumens, and slots within the electrical connectors may be aligned with the filar passageways to facilitate assembly. The lumen body may provide additional stiffness to the end of the lead where the lumen body is located to facilitate lead insertion into the medical device. The filar lumens of the lumen body may have a longitudinally straight configuration so that the portions of filars within the filar lumens are held in a longitudinally straight configuration.

Abstract: Devices, systems and methods are disclosed for treating or preventing gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve. The methods provide damaged interstitial cells of Cajal (ICC) with trophic factors via vagal afferent nerve fibers, thereby reversing ICC damage, and as a consequence improving gastric motility. The methods also increase levels of inhibitory neurotransmitters in the brain so as to decrease neural activity within the area postrema, or they deactivate a resting state neural network containing parts of the anterior insula and anterior cingulate cortex, which will thereby reduce abnormal interoception and visceral hypersensitivity.

Abstract: Devices, systems and methods are disclosed for treating or preventing gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders. The methods comprise transmitting impulses of energy non-invasively to selected nerve fibers, particularly those in a vagus nerve. The methods provide damaged interstitial cells of Cajal (ICC) with trophic factors via vagal afferent nerve fibers, thereby reversing ICC damage, and as a consequence improving gastric motility. The methods also increase levels of inhibitory neurotransmitters in the brain so as to decrease neural activity within the area postrema, or they deactivate a resting state neural network containing parts of the anterior insula and anterior cingulate cortex, which will thereby reduce abnormal interoception and visceral hypersensitivity.

Abstract: Energy is transmitted noninvasively to a patient using electrode-based stimulation devices or magnetic stimulation devices that are designed to non-invasively stimulate nerves selectively. The devices produce impulses that are used to treat atrial fibrillation, by stimulating a vagus nerve of a patient. The devices are also used to forecast the imminent onset of atrial fibrillation and then avert it by stimulating a vagus nerve.

Abstract: An patch and sensor assembly for use in an EP mapping system has two portions: a reusable portion and a disposable portion. The reusable portion houses the biosensors used in magnetic based location and mapping systems and the electrical lead necessary to communicate between the biosensor and the mapping system. The reusable portion may also contain a portion of the electrode necessary to receive electrical signals from the body of the patient. The disposable portion of the patch and sensor assembly contains an adhesive covered flexible patch having at least a portion of the electrode used to receive electrical signals form the body of the patient and may contain the electrical lead necessary to communicate such an electrical signal to the mapping system. The disposable portion contains a receptacle adapted to receive and mechanically secure the reusable portion to the disposable portion of the assembly.

Abstract: A coated electromyography needle including an anti-microbial, electrically insulative coating applied to non-tip portion of an electrode of the electromyography needle.

Abstract: Provided is a bio-signal detection electrode including: an electrode section made of a gel including an electrolytic solution; and a support section configured to support the electrode section with respect to an accessory, the electrode section adhering to the support section.

Abstract: A sensor for measuring biosignals is provided. The sensor comprises at least one electrode comprising: a substrate comprising a flexible non-conductive material; a conductive layer configured to transfer electrical signals; a gel layer configured to transfer electrical signals; and a barrier layer configured to protect the conductive layer and transfer electrical signals, wherein the barrier layer deposited on the substrate, the gel layer is deposited on the barrier layer so that the gel layer covers only a part of the barrier layer, and the conductive layer is deposited over an area of the barrier layer which is outside of an area of the barrier layer on which the gel layer is deposited.

Abstract: A pad tray includes a base portion and a recessed region that is formed in the front side of the base portion and is for accommodating an electrode pad, the recessed region having a bottom region and a sidewall region that extends up from the bottom region and is provided so as to surround the electrode pad.

Abstract: A biopotential electrode for transferring electrical signals with a subject that includes an electrical conductor, a membrane selectively permeable to ionic conduction for presenting a dry surface to the subject, and a conductive medium positioned in communication with a portion of the electrical conductor and a portion of the membrane. The electrical potentials are coupled from the subject across the membrane into the conductive medium and then transferred from the subject to the electrical conductor. In other embodiments, the electrical potentials may be transferred from the external conductor to the subject through the conductive medium across the membrane into the subject. Other embodiments include systems and methods for using the biopotential electrodes.

Abstract: An electroencephalographic headset includes: a supporter that includes expanding and contracting wires each having expansion and contraction properties and is to be attached to a head of a user by expansion and contraction of each of the expanding and contracting wires; and a plurality of electrodes that are provided to the supporter in defined placement.

Abstract: Described herein are nerve stimulating electrodes for use in evoked potential electrophysiological recording procedures and associated methods for use thereof. In one embodiment, a stimulating electrode assembly is provided that includes a non-conductive substrate, a first electrode mounted on the non-conductive substrate, and a second electrode mounted on the non-conductive substrate. The first and second electrodes are spaced apart along a longitudinal length of the assembly and extend along a lateral width of the assembly such that the electrode can be positioned at a plurality of laterally offsetting positions relative to a nerve extending longitudinally between the first and second electrodes while remaining in contact with the nerve.

Abstract: A biosensor electrode device and a method for fabricating the same are disclosed. The biosensor electrode device comprises a conductive substrate; at least one conductive spring, at least one probe, and an encapsulation member. Two ends of the conductive spring respectively connect with the conductive substrate and the probe. The probe moves close to or far away from the substrate through the elastic deformation of the conductive spring. The encapsulation member wraps the conductive substrate, the conductive springs and the probes but reveals a portion of each probe. The revealed probes contact skin of a testee for biomedical measurement. The device and method of the present invention can reduce the cost in mass-production. The biosensor electrode device will be a mainstream instrument in biomedical measurement.

Abstract: A self-adhering sensor for non-invasively attaching to a portion of a skin is provided. The sensor comprises a biocompatible substrate, and an array of solid nanoelectrodes coupled to the biocompatible substrate and configured to self-adhere to the skin. Also provided is a sensor for attaching to a portion of a skin, where the sensor comprises an array of solid electrodes configured to self-adhere to the skin, where each of the solid structures comprises a stem and one or more projections extending out from the stem, where both the stem and the projections are solid. The stem comprises a mechanical stopper to control the extent of penetration of the solid electrodes into the skin. The sensor further comprises an electrolyte coating disposed on one or more of the solid structures.

Abstract: The present invention is an article of manufacture and method for using same, comprising at least two self adhesive sensors having a paired offset potential of consistently below about +/?1.0 mV; and a data gathering device connected to the sensors capable of measuring the voltage difference between the sensors. The sensors preferably are AgCl coated Silver.

Abstract: A method is disclosed for fabricating a low-impedance nanoporous metal multiple electrode array for measuring electrophysiology activity. A patterned photoresist is applied to a substrate, in which the patterned photoresist corresponds to a pattern of the nanoporous metal multiple electrode array. A metal alloy including a sacrificial alloying element is deposited in the pattern of the nanoporous metal electrode array. The patterned photoresist is removed to expose the metal alloy as deposited. At least part of the sacrificial alloying element is removed from the metal alloy to create nanoporous metal electrode tips thereby forming the nanoporous metal multiple electrode array. The resultant nanoporous metal multiple electrode array has improved impedance characteristics in comparison to conventional multiple electrode arrays.

Abstract: An electrode set is disclosed that has two separable parts including an assembled base with printed circuit board basement, biasing member and top cover and an electrode. The basement and top cover may be made by metal or conductive material.

Abstract: A biopotential electrode for transferring electrical signals with a subject that includes an electrical conductor, a membrane selectively permeable to ionic conduction for presenting a dry surface to the subject, and a conductive medium positioned in communication with a portion of the electrical conductor and a portion of the membrane. The electrical potentials are coupled from the subject across the membrane into the conductive medium and then transferred from the subject to the electrical conductor. In other embodiments, the electrical potentials may be transferred from the external conductor to the subject through the conductive medium across the membrane into the subject. Other embodiments include systems and methods for using the biopotential electrodes.

Abstract: The present disclosure provides electrodes that possess components capable of indicating to an end-user when the electrode is in need of replacement. The electrode includes a substrate and a conductive composition on at least a portion of a surface of the substrate. In embodiments, the conductive composition includes at least one hydrogel and at least one component that precipitates from the hydrogel after repeated use of the electrode, thereby providing an indication to replace the electrode. In other embodiments, the electrodes include a hydrogel in combination with a pH indicator which changes its color or opacity upon repeated use of the electrode, thereby indicating an appropriate time for changing or replacing the electrode.

Abstract: The present disclosure provides electrodes that possess components capable of indicating to an end-user when the electrode is in need of replacement. In embodiments, the electrodes include a hydrogel in combination with a pH indicator which changes its color or opacity upon repeated use of the electrode, thereby indicating an appropriate time for changing or replacing the electrode.

Abstract: Provided is a bio-signal detection electrode including: an electrode section made of a gel including an electrolytic solution; and a support section configured to support the electrode section with respect to an accessory, the electrode section adhering to the support section.

Abstract: The present disclosure provides electrodes that possess components capable of indicating to an end-user when the electrode is in need of replacement. The electrode includes a substrate and a conductive composition on at least a portion of a surface of the substrate. The conductive composition includes at least one hydrogel and at least one component that precipitates from the hydrogel after repeated use of the electrode, thereby providing an indication to replace the electrode.

Abstract: A self-adhering sensor for non-invasively attaching to a portion of a skin is provided. The sensor comprises a biocompatible substrate, and an array of solid nanoelectrodes coupled to the biocompatible substrate and configured to self-adhere to the skin. Also provided is a sensor for attaching to a portion of a skin, where the sensor comprises an array of solid electrodes configured to self-adhere to the skin, where each of the solid structures comprises a stem and one or more projections extending out from the stem, where both the stem and the projections are solid. The stem comprises a mechanical stopper to control the extent of penetration of the solid electrodes into the skin. The sensor further comprises an electrolyte coating disposed on one or more of the solid structures.

Abstract: An electrode system for the measurement of biopotential signals includes a substrate. A microelectrode is coupled to the substrate. An accelerometer is coupled to the substrate. A biopotential amplifier is electrically coupled to the microelectrode and acceleration measurement circuit is electrically coupled to the accelerometer. A method of measuring a biopotential from a patient includes sensing a biopotential with a microelectrode. The biopotential is amplified with an amplifier in electrical communication with the microelectrode. A movement of the electrode is sensed with an accelerometer integrated with the electrode substrate. The sensed biopotential and the sensed movement are provided to an electronic controller. Portions of the sensed biopotential that correspond to sensed movement are identified as artifact contaminated portions.

Abstract: A bioelectrode comprising a skin-side, electrically conducting adhesive layer (7) and a flexible electrical connecting cable (4) which in an electrically insulating cable sheath (5) includes at least one electrical conductor (6), preferably in the form of a braid comprising a plurality of individual wires or conducting individual fibers, wherein the electrode-side end (4a) of the connecting cable (4) is arranged between two thermoplastic layers (2, 3) which are welded together at least region-wise, wherein both thermoplastic layers (2, 3) are electrically conducting and are electrically connected to the electrical conductor (6) of the connecting cable (4).

Abstract: An electrode including a non-conductive substrate having a top surface and at least one channel extending therethrough, an electrically conductive trace material positioned adjacent a portion of the top surface of the non-conductive substrate and extending through the channel, and adapted for electrically coupling to a power source, and second and third electrically conductive materials that are inert or more corrosion resistant than the trace material. The second material is positioned adjacent to and entirely covering a top surface of the trace material, and the third material is positioned adjacent to and entirely covering a top surface of the second electrically conductive material, and covers a portion of a top surface of the non-conductive substrate surrounding the second electrically conductive material. The electrode further includes a conductive hydrogel positioned adjacent to a portion of a top surface of the third electrically conductive material, but laterally offset from the trace material.

Abstract: A dry electrode for biomedical signal measuring sensor includes a conductive sponge, a conductive fabric, and a thin metal film. The conductive fabric covers the whole conductive sponge, and the thin metal film is disposed on one face of the conductive fabric opposite to the conductive sponge. When using the dry electrode in measuring biomedical signal, it is not necessary to apply a conductive gel on a patient's skin, at where the biomedical signal is to be measured. Without the need of applying the conductive gel, the dry electrode is readily for measuring biomedical signal at any time and can be conveniently used in measuring signal over a long period of time without the problem of an attenuated signal due to gradually becoming dried conductive gel.

Abstract: Provided is a method and apparatuses for measuring a biological signal, in which a biological signal of an examinee is detected via at least one interface that touches skin of the examinee, and a dummy signal is detected via a dummy interface Noise that is generated by a fluctuation in the electrical characteristics of the at least one interface is removed from the biological signal using the biological signal and the dummy signal.

Abstract: The present invention relates to sensory for measuring signals on the surface of the skin and for producing sensory. In the sensory in accordance with the invention, the electrode surfaces required for measuring of a signal and/or conductors required for transmitting of a signal have been fastened to the textile material of an outfit or accessory used on the body. In the method in accordance with the invention, the electrode surfaces required for the sensory and/or conductors are added to the textile material of an outfit or accessory used on the body.

Abstract: The invention relates to a method for monitoring an arrangement for determining a concentration of an analyte in a body fluid. The determination of the concentration of the analyte by means of the arrangement involves a procedure in which the analyte from the body fluid passes through an interface and is transported in a stream of liquid into a flowmeter chamber, in which a measurement is carried out to determine the concentration of the analyte. The evaluation of the measurement takes place in a signal processor. The monitoring of the arrangement comprises the following steps: measurement of measured values of at least two correlated system parameters of the arrangement by means of a sensor system, and comparison of the measured values with limit values stored for each of the system parameters in a storage unit, to obtain a combination of at least two comparison results.