Combined With Therapeutic Or Diverse Diagnostic Device Patents (Class 600/411)
  • Patent number: 11399900
    Abstract: A method may be provided to operate a medical system. First data may be provided for a first 3-dimensional (3D) image scan of an anatomical volume, with the first data identifying a blood vessel node in a first coordinate system for the first 3D image scan. Second data may be provided for a second 3D image scan of the anatomical volume, with the second data identifying the blood vessel node in a second coordinate system for the second 3D image scan. The first and second coordinate systems for the first and second 3D image scans of the anatomical volume may be co-registered using the blood vessel node identified in the first data and in the second data as a fiducial.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: August 2, 2022
    Assignee: Globus Medical, Inc.
    Inventors: Neil R. Crawford, Norbert Johnson
  • Patent number: 11378632
    Abstract: Disclosed embodiments provide an apparatus and method for imaging breast tissue of a subject, wherein a subject is positioned on a structure so that at least a portion of the subject's body is supported by the structure, magnetic resonance imaging is performed on the portion of the subject's body using an MRI system including a plurality of MRI coils positioned in proximity to the structure, wherein, while the portion of the subject's body is positioned upon the structure, breast tissue of the subject's body is compressed in the proximity of plurality of MRI coils.
    Type: Grant
    Filed: February 13, 2017
    Date of Patent: July 5, 2022
    Inventors: Irving N. Weinberg, Aleksandar Nelson Nacev
  • Patent number: 11375914
    Abstract: A method for producing an image representative of the vasculature of a subject using a MRI system includes the acquisition of a signal indicative of a subject' cardiac phase. During each heartbeat of the subject, image slices of a volume covering a region of interest (ROI) within the subject are acquired by applying a volume-selective venous suppression pulse to suppress (a) venous signal for an upper slice in the ROI; (b) venous signal for slices that are upstream for venous flow in the ROI; and (c) background signal from the upstream slices. Next, a slice-selective background suppression pulse is applied to suppress background signal of the upper slice. Following a quiescent time interval, a spectrally selective fat suppression pulse is applied to the entire volume to attenuate signal from background fat signal. Then, a simultaneous multi-slice acquisition of the upper slice and the upstream slices is performed.
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: July 5, 2022
    Assignees: Siemens Healthcare GmbH, NorthShore University Healthsystem
    Inventors: Shivraman Giri, Robert R. Edelman, Ioannis Koktzoglou, Himanshu Bhat
  • Patent number: 11350847
    Abstract: In one embodiment, a body part visualization system includes a medical instrument configured to be inserted into a body part of a living subject, a display, and processing circuitry configured to compute location coordinates of the medical instrument in the body part, and render to the display a first three-dimensional (3D) representation of the body part, the first 3D representation showing an external surface of the body part with a moving window, which moves over the external surface in the first 3D representation responsively to the computed location coordinates of the medical instrument so as to provide, via the window, an internal view of the first 3D representation of the body part, the internal view including a second 3D representation of at least a part of the medical instrument at the computed location coordinates.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: June 7, 2022
    Assignee: Biosense Webster (Israel) Ltd.
    Inventors: Meir Bar-Tal, Aharon Turgeman, Benjamin Cohen
  • Patent number: 11355230
    Abstract: A system and method of tractography labelling in the presence of a brain lesion. According to the disclosure, a composition of free water correction (FWC) tractography and non-FWC tractography sets into a single tractography set with a ‘degree of free water’ value assigned to each tract and/or fragment of tract geometry. A slider graphical user interface is introduced to dynamically adjust the free water threshold value that controls what tracts and/or fragments of tract geometry get shown. For example, only tracts or fragments of tract geometry with a degree of free water below the threshold are shown while the rest are hidden.
    Type: Grant
    Filed: October 15, 2021
    Date of Patent: June 7, 2022
    Assignee: SYNAPTIVE MEDICAL INC.
    Inventors: Wesley Bryan Hodges, Alicia McNeely, Sebastian Koga, Tim Hayes, Hayk Adamyan
  • Patent number: 11348230
    Abstract: Systems and methods for generating and tracking shapes of a target may be provided. The method may include obtaining at least one first resolution image corresponding to at least one of a sequence of time frames of a medical scan. The method may include determining, according to a predictive model, one or more shape parameters regarding a shape of a target from the at least one first resolution image. The method may include determining, based on the one or more shape parameters and a shape model, at least one shape of the target from the at least one first resolution image. The method may further include generating a second resolution visual representation of the target by rendering the determined shape of the target.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: May 31, 2022
    Assignee: SHANGHAI UNITED IMAGING INTELLIGENCE CO., LTD.
    Inventors: Shanhui Sun, Zhang Chen, Terrence Chen
  • Patent number: 11334976
    Abstract: Accessed from memory are i) a first brain image, ii) a second brain image, iii) a difference map, and iv) a connectivity element. A GUI may include: concurrently displaying each of these elements. User input to the GUI is received. A location of the user input is determined. The operations also include responsive to determining that the location of the user input is within the display of the first brain image, modifications are made to the display of the i) second brain image, ii) the difference map, and iii) the connectivity element to highlight elements of the display that correspond to an element of the first brain image that corresponds to the location of the user input.
    Type: Grant
    Filed: November 16, 2021
    Date of Patent: May 17, 2022
    Assignee: Omniscient Neurotechnology Pty Limited
    Inventors: Michael Edward Sughrue, Stephane Philippe Doyen, Peter James Nicholas, Xinling Jiang
  • Patent number: 11331073
    Abstract: A device for vibration controlled transient elastography, in particular to quantify liver fibrosis, includes an ultrasound probe for elastography comprising a probe casing, at least one ultrasound transducer having a symmetry axis, a vibrator, and a force sensor, wherein the vibrator is arranged to induce a movement of the probe casing along the symmetry axis of the ultrasound transducer, the ultrasound transducer being bound to the probe casing with no motion of the ultrasound transducer relative to the probe casing, and wherein the device includes a signal generator configured to issue a contact ready signal when the force applied by the probe on the to-be-measured viscoelastic medium is greater than a minimum contact force threshold. The signal generator may further be configured to issue a measurement ready signal when the force is greater than a minimum measurement force threshold.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: May 17, 2022
    Assignee: ECHOSENS
    Inventor: Laurent Sandrin
  • Patent number: 11324969
    Abstract: A method for focusing an X-ray method is provided and the method includes: emitting an electron beam by an electron beam generator; shooting the electron beam onto a target to generate an X-ray beam; and causing the X-ray beam to pass through each collimating channel of a same collimating channel group of a collimator to focus on a focus of the collimating channel group. The collimator includes at least one collimating channel group. Each collimating channel group includes at least two collimating channels. The same collimating channel group has one focus or a plurality of focuses.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: May 10, 2022
    Assignees: OUR UNITED CORPORATION, SHENZHEN OUR NEW MEDICAL TECHNOLOGIES DEVELOPMENT
    Inventors: Haifeng Liu, Xiaoqi Lin, Peng Zan
  • Patent number: 11311739
    Abstract: A therapeutic method of reducing or eliminating viral infections in vivo includes subjecting a virally infected patient to one of a variety of strong magnetic fields. A static magnetic field has a magnetic field intensity of at least about 5 nanoTesla sufficient to be effective to disrupt viral metabolism. An alternating magnetic field has a magnetic field intensity of at least 0.1 nanoTesla sufficient to be effective to disrupt viral metabolism. A method of disrupting viral metabolism includes subjecting an infected patient or a mixture of live host cells and virus to the alternating magnetic field. A virus disruption apparatus includes a magnetic field generator of static or alternating magnetic fields. The magnetic field generator is selected from a Magnetic Resonance Imaging device, at least one permanent magnet, at least one superconducting magnet, at least one solenoid, and any combination thereof.
    Type: Grant
    Filed: July 28, 2021
    Date of Patent: April 26, 2022
    Inventor: Harvey Wayne Ko
  • Patent number: 11311747
    Abstract: The present disclosure is related to systems and methods for isocenter calibration. The method includes providing a phantom including a first member and a second member with a fixed position relationship. The method includes acquiring, using a first device, at least one first image of the first member of the phantom. The method includes determining, based on the at least one first image, a first position relationship between a first isocenter of the first device and the first member. The method includes acquiring, using a second device, at least one second image of the second member of the phantom. The method includes determining, based on the at least one second image and the fixed position relationship, a second position relationship between a second isocenter of the second device and the first member. The method includes determining, based on the first position relationship and the second position relationship, a third position relationship between the first isocenter and the second isocenter.
    Type: Grant
    Filed: July 16, 2020
    Date of Patent: April 26, 2022
    Assignee: UIH AMERICA, INC.
    Inventor: Jonathan Maltz
  • Patent number: 11304645
    Abstract: Methods, apparatus, and systems for medical procedures are disclosed herein and include receiving a first set of biometric data for a first portion of a body part and determining a first range of values in the first set of biometric data, determining first visual characteristics based on the first range of values and rendering a global view of the first portion of the body part rendered with the first visual characteristics. A second range of values in a second set of biometric data for a second portion of the body part may be determined and the second portion of the body part may be a subset of the first portion of the body part. Second visual characteristics may be determined based on the second range of values and a local view including the second portion of the body part rendered with the second visual characteristics may be rendered.
    Type: Grant
    Filed: October 15, 2019
    Date of Patent: April 19, 2022
    Assignee: BIOSENSE WEBSTER (ISRAEL) LTD.
    Inventors: Andres Claudio Altmann, Vadim Gliner, Israel Zilberman, Yair Palti, Remi Bettan
  • Patent number: 11304683
    Abstract: The subject matter discussed herein relates to multi-modal image alignment to facilitate biopsy procedures and post-biopsy procedures. In one such example, prostate structures (or other suitable anatomic features or structures) are automatically segmented in pre-biopsy MR and pre-biopsy ultrasound images. Thereafter, pre-biopsy MR and pre-biopsy ultrasound contours are aligned. To account for non-linear deformation of the imaged anatomic structure, a patient-specific transformation model is trained via deep learning based at least in part on the pre-biopsy ultrasound images. The pre-biopsy ultrasound images that are overlaid with the pre-biopsy MR contours and based off the deformable transformation model are then aligned with the biopsy ultrasound images. Such real-time alignment using multi-modality imaging techniques provides guidance during the biopsy and post-biopsy system.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: April 19, 2022
    Assignee: General Electric Company
    Inventors: Jhimli Mitra, Thomas Kwok-Fah Foo, Desmond Teck Beng Yeo, David Martin Mills, Soumya Ghose, Michael John MacDonald
  • Patent number: 11291860
    Abstract: A magnetic resonance apparatus which may include: a body portion having a cavity with a first and second ends and at least one opening situated at one of the first and second ends. The cavity may define a longitudinal axis (LA) extending between the first and second ends. At least one main magnet may generate a main magnetic field having a substantially homogenous magnetic field within the cavity. A center shim (CS) which may be formed from a ring having opposed edges and which may extend along a length of the longitudinal axis of the cavity. One or more discrete shims (DSs) may be situated between the CS and at least one of the first and second ends.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: April 5, 2022
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Jeffrey Edward Leach, Philip Alexander Jonas, Johannes Adrianus Overweg, Viktor Mokhnatyuk
  • Patent number: 11291509
    Abstract: Devices and methods are provide for facilitating registration and calibration of surface imaging systems. Tracking marker support structures are described that include one or more fiducial reference markers, where the tracking marker support structures are configured to be removably and securely attached to a skeletal region of a patient. Methods are provided in which a tracking marker support structure is attached to a skeletal region in a pre-selected orientation, thereby establishing an intraoperative reference direction associated with the intraoperative position of the patient, which is employed for guiding the initial registration between intraoperatively acquired surface data and volumetric image data. In other example embodiments, the tracking marker support structure may be employed for assessing the validity of a calibration transformation between a tracking system and a surface imaging system.
    Type: Grant
    Filed: October 15, 2019
    Date of Patent: April 5, 2022
    Assignee: 7D SURGICAL ULC
    Inventors: Peter Siegler, Michael Leung, Adrian Mariampillai, Beau Anthony Standish, Victor X. D. Yang
  • Patent number: 11289179
    Abstract: Provided is a system providing a solution for improving prescription drug compliance monitoring and compliance. Prescription drug compliance monitoring may be achieved by using patient's electronic device to initiate secure digital imaging. Medications may be dispensed in containers with pre-printed encoded unique identifiers and markings. The patient may use the digital camera in their smart phone to take a picture of the dispensed blister pack which may be processed and analyzed. Analysis may include assessment of the number of pills taken from and remaining in the uniquely identified blister pack. Package identification and consumption information may then be linked with other prescription information to determine if the observed rate of use is compliant with the legal prescription and to document that the imaged medication package is the same as the dispensed medication package. Data may also be linked with pharmacologic and clinical data to categorize risk and urgency of misuse.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: March 29, 2022
    Assignee: Compliance Strategies, LLC
    Inventors: Steven Brown, Steven Dickerson
  • Patent number: 11288803
    Abstract: Devices, systems, methods for validating ablation results in a patient's brain are provided. In some embodiments, the method for validating ablation result in a patient's brain includes obtaining magnetic resonance (MR) data of the patient's brain, by use of a magnetic resonance imaging (MRI) device; obtaining first imaging data of the patient's brain, by use of the MRI device; extracting, by use of computing device in communication with the MRI device, first fiber tracts passing through an anatomy in the patient's brain based on the first imaging data; obtaining, by use of the MRI device, second imaging data of the patient's brain after ablation of the anatomy in the patient's brain has started; extracting second fiber tracts passing through the anatomy in the patient's brain based on the second imaging data; and outputting a graphical representation of a comparison between the first fiber tracts and the second fiber tracts.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: March 29, 2022
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Lyubomir Georgiev Zagorchev, Joel Haaf
  • Patent number: 11260126
    Abstract: The present invention provides acoustically activated liposome compositions for use as drug delivery vehicles, and to methods for drug release and drug delivery for therapeutic applications.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: March 1, 2022
    Assignee: University of Otago
    Inventors: John Noble James Reynolds, Eng Wui Tan, Brian Ian Hyland, Guy Nicholas Louis Jameson, Maung Mo Aung Myint, Sean Marshall Mackay, Jeffery Russell Wickens
  • Patent number: 11253673
    Abstract: The system receives a raw signal carrying information related to slow wave activity; buffers a portion of the raw signal; determines a timing of slow wave events in the buffered portion of the raw signal; filters the raw signal; determines a timing of slow wave events in the filtered raw signal; compares the timing of the slow wave events in the buffered portion of the raw signal to the timing of the slow wave events in the filtered raw signal; determines a first correction factor associated with reducing slow wave activity in the subject and a second correction factor associated with enhancing slow wave activity in the subject; and adjusts a timing of the stimulation provided to the subject during the sleep session based on the first and/or second correction factors.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: February 22, 2022
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Gary Nelson Garcia Molina, Anandi Mahadevan, Surya Subrahmanya Sreeram Vissapragada Venkata Satya
  • Patent number: 11253731
    Abstract: A device (1) for therapeutic treatment of a target (2) comprising at least one ultrasound transducer (3) for generating and transmitting ultrasound pulses to the target and at least one detector (4) to detect ultrasound waves (6) backscattered from structures. The device (1) comprises a signal processing unit (8) to select an output of the at least one detector (4) caused by backscattered waves (6). The selected output has a frequency around an even harmonics of the emitted frequency (f) of the ultrasound pulses. The device (1) comprises a processor (7) to provide an output of the selected signal indicative of a parameter of the backscattered waves (6) in the frequency band around the even harmonics. The processor calculates if the parameter of the backscattered waves (6) in the frequency band is above a preset threshold (13), and provides an alert signal (9) when the parameter exceeds the threshold (13).
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: February 22, 2022
    Assignee: Theraclion SA
    Inventor: Bjoern Gerold
  • Patent number: 11249127
    Abstract: An electronic device may include a shaft insertable into a target area, and an electronic component configured to generate a signal. The electronic component may be on or within the shaft. The electronic device may also include at least one antenna on or within the shaft. The electronic device may also include a receiver operatively coupled to the antenna. The receiver may monitor an electrical characteristic of the antenna to identify an effect of an electromagnetic field on the electrical characteristic of the antenna. The electronic device may also include a processor communicatively coupled to the receiver. At least one of the receiver and the processor may predict an effect of the electromagnetic field on the signal generated by the electronic component, based at least in part on the effect of the electromagnetic field on the electrical characteristic of the antenna.
    Type: Grant
    Filed: April 7, 2020
    Date of Patent: February 15, 2022
    Assignee: Boston Scientific Scimed, Inc.
    Inventor: Russell P. Dresher
  • Patent number: 11241188
    Abstract: A system and methods for monitoring and controlling a mental state of a subject are provided. In some aspects, a method includes receiving physiological and behavioral data acquired using the plurality of sensors while the subject is performing a task, and applying, using the data, a state-space framework to determine a plurality of decoder parameters correlating brain activity and behavior with a mental state of the subject. The method also includes identifying the mental state of the subject using the decoder parameters, and generating a report indicating the mental state of the subject. In some aspects, the method further includes generating, based on the identified mental state, a brain stimulation to treat a brain condition of the subject.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: February 8, 2022
    Assignees: The General Hospital Corporation, Trustees of Boston University
    Inventors: Alik Widge, Emad Eskandar, Darin Dougherty, Uri Tzvi Eden, Xinyi Deng, Ali Yousefi, Angelique Paulk
  • Patent number: 11241590
    Abstract: Methods and systems are disclosed for radiating a moving object. The method may comprise acquiring a plurality of indicators of the phase of a physiological cycle of a patient and a plurality of images of the patient that include a target. Each image may be taken at a different phase of the physiological cycle and may be registered to the phase at which the image was taken. The method may also include identifying the target in each of the plurality of images, calculating a dose of radiation required to treat the target, calculating the number, orientation, and dwell time of one or more radiation beams required to deliver the calculated required dose of radiation to the target, and calculating a position of each of the one or more radiation beams required to achieve the calculated orientation. Each position may be a function of the phase of the physiological cycle to which each of the plurality of images is registered.
    Type: Grant
    Filed: September 30, 2020
    Date of Patent: February 8, 2022
    Assignee: VARIAN MEDICAL SYSTEMS, INC.
    Inventors: Thilaka Sumanaweera, Patrick Maguire, Edward Gardner
  • Patent number: 11229376
    Abstract: A medical instrument for magnetic resonance imaging guided radiotherapy includes a magnetic resonance imaging system for acquiring magnetic resonance data from an imaging zone, a radiation source for emitting X-ray or gamma ray radiation directed at a target zone within the imaging zone, wherein the radiation from the radiation source directed to the target zone passes through a radiation window of the magnetic resonance imaging system. The magnetic resonance imaging system includes at least one radiation transparent electrical transmission line, which is configured for transmitting an electrical signal and which extends through the radiation window, wherein the electrical transmission line is provided by a microstrip comprising a conductor line extending parallel to the ground layer, wherein the conductor line and the ground layer are separated from each other by a dielectric substrate.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: January 25, 2022
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Jehki Juhani Pusa, Annemaria Halkola, Teemu Niemi
  • Patent number: 11219406
    Abstract: Devices for testing distal colonic and anorectal function. In at least one embodiment of a device of the present disclosure, the device comprises a flexible central support, a first bag or balloon surrounding at least part of the flexible central support; and a first plurality of sensors positioned upon or embedded within a surface of the first bag or balloon, each of the first plurality of sensors positioned a known distance from each other; wherein the first plurality of sensors are configured to obtain pressure measurements on the surface of the first bag or balloon when the device is operated within a mammalian gastrointestinal tract.
    Type: Grant
    Filed: July 31, 2017
    Date of Patent: January 11, 2022
    Assignee: GI Bionics LLC
    Inventors: Hans Gregersen, Ghassan S. Kassab
  • Patent number: 11213255
    Abstract: An information processing device, an information processing method, and a recording medium storing an information processing program. The information processing device and the information processing method include obtaining measurement data, accepting a specification of time in the measurement data as a specified time, reducing noise from the measurement data using each one of a plurality of methods, evaluating a result of noise reduction at the specified time, the noise reduction being performed using each one of the plurality of methods, and selecting one of the plurality of methods based on the evaluated result of noise reduction. The recording medium storing the information processing program for causing a computer to execute the information processing method.
    Type: Grant
    Filed: June 28, 2018
    Date of Patent: January 4, 2022
    Assignee: RICOH COMPANY, LTD.
    Inventor: Satoshi Hikida
  • Patent number: 11213273
    Abstract: A method for ultrasound image acquisition for tracking an object of interest in ultrasound image information includes receiving X-ray image information and ultrasound image information, determining, before the tracking, a spatial relationship between the X-ray image information and the ultrasound image information, detecting an object of interest in the X-ray image information and steering two-dimensional ultrasound image acquisition such that the object of interest is within an ultrasound image plane.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: January 4, 2022
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Pascal Yves François Cathier, Olivier Pierre Nempont, Raoul Florent
  • Patent number: 11205851
    Abstract: A radio frequency identification (RFID) tag includes a power harvesting circuit that operates generate power for the RFID tag from a continuous wave of a radio frequency (RF) signal. The RFID tag further includes a tuning circuit that is tuned based on a capacitance setting, where the capacitance setting is indicative of a power level of the power. The RFID tag further includes a processing module operably coupled to the tuning circuit, where the processing module operates to generate the capacitance setting to obtain a desired power level for the power.
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: December 21, 2021
    Assignee: RFMicron, Inc.
    Inventors: Shahriar Rokhsaz, Brian David Young, Marwan Hassoun
  • Patent number: 11179579
    Abstract: An image-guided radiation therapy apparatus comprises: a high-energy ray source configured for radiation therapy of an object; and a KV ray source, a first and second PET detectors, and a CT detector for KV CT and PET imaging for guiding the radiation therapy. The KV ray source is placed on, or at an inner or outer side of the first PET detector; the second PET detector and the CT detector are configured to receive the KV ray to perform KV CT imaging; the PET detectors are further configured to receive gamma ray emitted by the object to perform PET imaging.
    Type: Grant
    Filed: December 29, 2018
    Date of Patent: November 23, 2021
    Assignee: Tsinghua University
    Inventors: Hewei Gao, Zhiqiang Chen, Li Zhang, Yuxiang Xing
  • Patent number: 11182907
    Abstract: Systems and methods for managing motions of an anatomical region of interest of a patient during image-guided radiotherapy are disclosed. An exemplary system may include an image acquisition device, a radiotherapy device, and a processor device. The processor device may be configured to control the image acquisition device to acquire at least one 2D image. Each 2D image may include a cross-sectional image of the anatomical region of interest. The processor device may also be configured to perform automatic contouring in each 2D image to extract a set of contour elements segmenting the cross-sectional image of the anatomical region of interest in that 2D image. The processor device may be further configured to match the set of contour elements to a 3D surface image of the anatomical region of interest to determine a motion of the anatomical region of interest and to control radiation delivery based on the determined motion.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: November 23, 2021
    Assignee: Elekta LTD.
    Inventor: Martin Emile Lachaine
  • Patent number: 11177882
    Abstract: The invention relates to an optical receiver for digital signals in the visible range, with a photodetector consisting of a two-dimensional array of avalanche photodiodes (APD), connected in parallel and with an output representing the sum of the individual responses of each APD. The photodetector requires a low on incidence power and therefore allows to detect specific optical signals in a very well-defined range of powers and frequencies, in real high intensity back light conditions without the requirement of optical filters, which allows a great advance in the utility and applicability of communication with visible light with digital modulation techniques.
    Type: Grant
    Filed: January 4, 2019
    Date of Patent: November 16, 2021
    Assignee: UNIVERSIDAD ANTONIO NARIÑO
    Inventors: Luis Fernando Castaneda Melo, Javier Fernando Castano Forero, Rafael Maria Gutierrez Salamanca
  • Patent number: 11160454
    Abstract: Described here are systems and methods for visualizing thermal ablation lesions by imaging specific chemical compounds that are created during thermal ablation procedures, such as cardiac ablation procedures. When a cardiac ablation procedure is performed, a central area of coagulative necrosis is created at the treatment site. This necrotic region is surrounded by layers of tissues with ultra-structural and electrophysiological changes. Two particular changes include the denaturation of proteins and the formation of ferric iron containing chemical compounds, such as methemoglobin and metmyoglobin. The formation of and distribution of such chemical compounds can be imaged with the appropriate systems and methods. Accordingly, these chemical compounds can be utilized as biomarkers that indicate the presence and physical characteristics of thermal ablation lesions. Imaging can be performed using magnetic resonance imaging, optical imaging, or photoacoustic imaging, as examples.
    Type: Grant
    Filed: April 8, 2014
    Date of Patent: November 2, 2021
    Assignee: Sunnybrook Research Institute
    Inventors: Venkat R. Swaminathan, Haydar Celik, Graham A. Wright
  • Patent number: 11162999
    Abstract: A coil arrangement for generating a configurable 3D magnetic field vector inside a cavity, comprises a solenoid forming the cavity and having a first axis, a first pair of coils having a second common axis, and a second pair of coils having a third common axis, the three axes intersecting in a point where a chip to be tested is to be located. A test arrangement further comprises a container for holding a liquid and having at least one opening for providing access to the at least one cavity. A test system further comprises an electrical unit with a plurality of current sources, and a mechanical positioning mechanism for placing and holding the chip to be tested.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: November 2, 2021
    Assignee: MELEXIS TECHNOLOGIES SA
    Inventors: Olivier Dubrulle, Marie Dlevaque, Pierre Letousey
  • Patent number: 11141229
    Abstract: An end effector of a robotic surgery system that includes a fixed plate for attaching an end of a robotic arm, a shaft extending from the fixed plate, a sliding plate moveable relative to the fixed plate along an axial direction of the shaft, a hub assembly mounted to the sliding plate and operatively engaged with the shaft. The hub assembly includes an idler hub, and an inner bearing moveable relative to the idler hub and operatively engaged with the shaft, whereby rotation of the inner bearing moves the sliding plate along the axial direction of the shaft. The end effector further includes a pulley that includes a driven wheel connected to the inner bearing operatively engaged with a motor, whereby rotation of the driven wheel drives rotation of the inner bearing.
    Type: Grant
    Filed: September 16, 2019
    Date of Patent: October 12, 2021
    Assignee: Rubicon Spine LLC
    Inventors: Thomas Sweeney, II, John D. Kuczynski
  • Patent number: 11135325
    Abstract: Various embodiments disclosed relate to methods and compositions for antimicrobial treatment. In various embodiments, the present invention provides a method of antimicrobial treatment. The method includes at least one of exposing at least one microbe to a magnetic field, and contacting the at least one microbe with at least one nanoparticle including iron.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: October 5, 2021
    Inventors: Marek A. Osinski, Hugh D. C. Smyth, Leisha Marie Armijo, Hennaka Mudiyanselage Herath Nihal Bandara
  • Patent number: 11129574
    Abstract: Cardiac catheterization is conducted with a probe having a plurality of sensors. The heart is displayed as a first graphic image. Signals from the sensors are processed according to a predefined algorithm to generate respective outputs, A region on the first graphic image that is less than all of the first graphic image is selected according to locations of the sensors, and values derived from outputs of the sensors are displayed on the selected region as a second graphic image. Thereafter, the second graphic image is removed and replaced by an updated version.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: September 28, 2021
    Assignee: Biosense Webster (Israel) Ltd.
    Inventors: Assaf Cohen, Lilia Suzdalnitsky, Eduard Filipov, Ido Ilan
  • Patent number: 11122991
    Abstract: Methods, devices and systems for location of the disposition of a medical probe in a subject are disclosed. An array of electromagnetic drive coil sets, each set having two or three dimensionally oriented drive coils, a sensor coil being electromagnetically communicative with the array of electromagnetic drive coil sets, a discrete core wire providing response to electrical stimuli of the subject, and a system controller communicative with and adapted to energize one or more of the electromagnetic coils in the array of electromagnetic drive coil sets are disclosed. The energizing of the one or more of the electromagnetic coils including one or more of energizing the coils singly, or in pairs of x-y and y-z or x-z coils while measuring the response of the sensor coil, whereby the system uses the measurements of the responses of the sensor coil to calculate the location of the sensor coil relative to said drive coil sets.
    Type: Grant
    Filed: October 15, 2018
    Date of Patent: September 21, 2021
    Assignee: TELEFLEX LIFE SCIENCES LIMITED
    Inventors: Peter E. Nelson, Robert D. Zellers, Charles W. Henry
  • Patent number: 11126394
    Abstract: A content management method uses a portable multifunction device 202 to detect human-inaudible acoustic signals 210, when that signal is heard from the surrounding environment by a device microphone 113 or is output by the device's audio circuitry 100. The device 202 extracts a code from the inaudible signal and supplies the code via wired or wireless communication 232, along with additional optional data regarding the device and/or its user, to a content management system 200. Upon receipt of the code, indicating the received inaudible signal 210 from the portable multifunction device 202, the content management system 200 may provide particular content or a pointer to that content to the portable multifunction device 202, the content being selected based on the particular inaudible signal received. Additional threshold triggers 502 may be delivered to require additional actions to unlock the content.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: September 21, 2021
    Assignee: LISNR, Inc.
    Inventors: Rodney B. Williams, Christoper M. Ostoich, Christopher D. Ridenour
  • Patent number: 11116404
    Abstract: Disclosed is a patch guide method including acquiring a 3-dimensional scan model including the head of an object by using a depth camera, by a computer, acquiring a 3-dimensional brain MRI model of the object, matching the scan model and the brain MRI model to acquire a matched model, acquiring an image captured by photographing the head of the object by using the depth camera, and matching one location of the captured image and one location on the matched model.
    Type: Grant
    Filed: August 28, 2017
    Date of Patent: September 14, 2021
    Assignee: NEUROPHET Inc.
    Inventors: Dong Hyeon Kim, Jun Kil Been
  • Patent number: 11120907
    Abstract: A system and method of coordinated motion includes a device with one or more movable elements and one or more processors. The device is configured to discover a second device, determine a desired type of coordinated motion based on the discovery of the second device, request a movement token of a first type from a token service, the first type being selected based on the desired type of coordinated motion, receive the movement token from the token service, receive configuration data, kinematic data, or planned motion data for the second device, plan a first motion for a movable element of the movable elements based on the first type of the movement token and the configuration data, the kinematic data, or the planned motion data for the second device, and execute the first motion while the device holds the movement token. The device and the second device are different heterogeneous devices.
    Type: Grant
    Filed: March 18, 2019
    Date of Patent: September 14, 2021
    Assignee: INTUITIVE SURGICAL OPERATIONS, INC.
    Inventors: Mahdi Azizian, Johnathan M. Sorger, Simon P. Dimaio
  • Patent number: 11083912
    Abstract: Systems and methods for the delivery of linear accelerator radiotherapy in conjunction with magnetic resonance imaging in which components of a linear accelerator may be placed in shielding containers around a gantry, may be connected with RF waveguides, and may employ various systems and methods for magnetic and radio frequency shielding.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: August 10, 2021
    Assignee: VIEWRAY TECHNOLOGIES, INC.
    Inventors: James F. Dempsey, Shmaryu M. Shvartsman
  • Patent number: 11083562
    Abstract: A method of generating a patient-specific prosthesis includes receiving anatomic imaging data representative of a portion of a patient's anatomy. A first digital representation of the anatomic imaging data is defined. The first digital representation of the anatomic imaging data is modified. A second digital representation of the portion of the patient's anatomy is defined based on the modifying of the first digital representation of the anatomic imaging data. A patient-specific prosthesis is generated based at least in part on the second digital representation of the anatomic imaging data.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: August 10, 2021
    Assignee: Aortica Corporation
    Inventors: Thomas C. Douthitt, Richard Van Bibber, Arun Palligaranai Tirumalai, Prashanth Dumpuri
  • Patent number: 11083435
    Abstract: An ultrasound imaging system includes a transducer array configured to transmit an ultrasound pressure field and receive an echo pressure field for a contrast-enhanced scan, and generate an electrical signal indicative of the received echo pressure field. The system further includes a signal processor configured to process the electrical signal and generate at least contrast enhanced ultrasound (CEUS) data indicative of nonlinear signal in the electrical signal. The system further includes a microbubble processor configured to process the CEUS data and generate microbubble data based on a predetermined contrast-agent microbubble size, shape and adjacency for microbubbles of interest. The system further includes a display configured to display a microbubble image indicative of the microbubble data.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: August 10, 2021
    Assignee: BK MEDICAL APS
    Inventors: Ramin Moshavegh, Fredrik Gran
  • Patent number: 11064965
    Abstract: A respiratory motion signal generation method operates on emission data (22) of an imaging subject in an imaging field of view (FOV) acquired by a positron emission tomography (PET) or single photon emission computed tomography (SPECT) imaging device (10). An array of regions (32) is defined in the imaging FOV without reference to anatomy of the imaging subject. For each region of the array of regions defined in the imaging FOV, an activity position versus time curve (54) is computed from the emission data acquired by the PET or SPECT imaging device. Frequency-selective filtering of the activity position versus time curves is performed to generate filtered activity position versus time curves. At least one motion signal (66) is generated by combining the filtered activity position versus time curves of at least a selected sub-set of the regions.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: July 20, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Andre Frank Salomon, Bin Zhang, Andreas Goedicke, Patrick Olivier
  • Patent number: 11042982
    Abstract: An ultra-dense electrode-based brain imaging system with high spatial and temporal resolution. A Sparsity and Smoothness enhanced Method Of Optimized electrical TomograpHy (s-SMOOTH) based reconstruction technique to improve the spatial resolution and localization accuracy of reconstructed brain images is described. Also described is a graph Fractional-Order Total Variation (gFOTV) based reconstruction technique to improve the spatial resolution and localization accuracy of reconstructed brain images.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: June 22, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Wentai Liu, Ying Li, Jing Qin, Chi-Wei Chang, Yi-Kai Lo
  • Patent number: 11039757
    Abstract: In various embodiments, the present invention teaches methods and related systems for imaging the coronary arteries in high spatiotemporal resolution for the assessment of coronary stenosis. In some embodiments, the method teaches the use of a 3D radial k-space trajectory, continuous acquisition, retrospective cardiac and respiratory self-gating, and non-rigid cardiac and respiratory motion correction to reconstruct any arbitrary cardiac phase with minimal motion artifacts and high image quality.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: June 22, 2021
    Assignee: Cedars-Sinai Medical Center
    Inventors: Debiao Li, Jianing Pang
  • Patent number: 11034580
    Abstract: The present invention provides stem cells loaded with bi-functional magnetic nanoparticles (nanoparticle-loaded stem cells (NLSC)) that both: a) heat in an alternating magnetic field (AMF); and b) provide MRI contrast enhancement for MR-guided hyperthermia. The nanoparticles in the NLSC are non-toxic, and do not alter stem cell proliferation and differentiation, the nanoparticles do however, become heated in an alternating magnetic field, enabling therapeutic applications for cancer treatment. Due to the fact that circulating stem cells home to tumors and metastasis, and participate in neovascularization of growing tumors, the NLSC of the present invention allows tracking of the tissue distribution of infused stem cells and selective heating of targeted tissues with AMF. NLSC can deliver hyperthermia to hypoxic areas in tumors for sensitization of those areas to subsequent treatment, thus delivering therapy to the most treatment-resistant tumor regions.
    Type: Grant
    Filed: December 25, 2019
    Date of Patent: June 15, 2021
    Inventor: Lyubov Ostrovska
  • Patent number: 11033195
    Abstract: A method and system for extracting cardiac cycle parameters from a respiration signal is disclosed. The technique comprises an array of piezoelectric sensors planted on the chest. The chest membrane exhibits the characteristics of bulky attenuator with certain time delay. Contractions and expansions of the heart and lungs muscles model a mechanical load and produce a relative induced strain on the piezoelectric sheet which in turn causes the piezoelectric material to generate a corresponding conformal voltage signal that is mapped with the heart actions. The resultant voltage signal is therefore used to extract and model the corresponding heart parameters utilizing piezoelectric as well as signal processing theories. a direct relationship is established between the output voltage produced by the piezoelectric transducer under hold breathing and the respiration signal collected by the same transducer with respiration.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: June 15, 2021
    Assignee: United Arab Emirates University
    Inventors: Mahmoud F. Y. Al Ahmad, Areen Abdallah Romi Allataifeh
  • Patent number: 11026750
    Abstract: An apparatus and method for surgical tracking comprises an imaging device that generates an image of a tissue volume; an electromagnetic (EM) sensor that creates a reference frame for EM tracking in three dimensions; at least one EM sensor adapted to be attached to the tissue to track local deformation and movement of the tissue volume; a processor that registers the image with the EM-tracked tissue volume and surgical tool in real time, and produces an output; and a feedback device that provides feedback about the location of the surgical tool relative to the tissue volume, based on the processor output. Embodiments are particularly useful in soft tissue, such as breast, where deformation before and during a procedure such as tumor resection complicate tracking of the tissue volume and a surgical tool.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: June 8, 2021
    Assignees: Queen's University at Kingston, Kingston Health Sciences Centre
    Inventors: Gabor Fichtinger, Tamas Ungi, John F. Rudan, Andras Lasso, C. Jay Engel, Gabrielle Gauvin, Caitlin Yeo
  • Patent number: 11016159
    Abstract: A method for high spatial and temporal resolution dynamic contrast enhanced magnetic resonance imaging using a random subsampled Cartesian k-space using a Poisson-disk random pattern acquisition strategy and a compressed sensing reconstruction algorithm incorporating magnitude image subtraction is presented. One reconstruction uses a split-Bregman minimization of the sum of the L1 norm of the pixel-wise magnitude difference between two successive temporal frames, a fidelity term and a total variation (TV) sparsity term.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: May 25, 2021
    Assignee: The Regents of the University of California
    Inventors: Peng Hu, Stanislas Rapacchi