Combined With Therapeutic Or Diverse Diagnostic Device Patents (Class 600/411)
  • Patent number: 11064965
    Abstract: A respiratory motion signal generation method operates on emission data (22) of an imaging subject in an imaging field of view (FOV) acquired by a positron emission tomography (PET) or single photon emission computed tomography (SPECT) imaging device (10). An array of regions (32) is defined in the imaging FOV without reference to anatomy of the imaging subject. For each region of the array of regions defined in the imaging FOV, an activity position versus time curve (54) is computed from the emission data acquired by the PET or SPECT imaging device. Frequency-selective filtering of the activity position versus time curves is performed to generate filtered activity position versus time curves. At least one motion signal (66) is generated by combining the filtered activity position versus time curves of at least a selected sub-set of the regions.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: July 20, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Andre Frank Salomon, Bin Zhang, Andreas Goedicke, Patrick Olivier
  • Patent number: 11039757
    Abstract: In various embodiments, the present invention teaches methods and related systems for imaging the coronary arteries in high spatiotemporal resolution for the assessment of coronary stenosis. In some embodiments, the method teaches the use of a 3D radial k-space trajectory, continuous acquisition, retrospective cardiac and respiratory self-gating, and non-rigid cardiac and respiratory motion correction to reconstruct any arbitrary cardiac phase with minimal motion artifacts and high image quality.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: June 22, 2021
    Assignee: Cedars-Sinai Medical Center
    Inventors: Debiao Li, Jianing Pang
  • Patent number: 11042982
    Abstract: An ultra-dense electrode-based brain imaging system with high spatial and temporal resolution. A Sparsity and Smoothness enhanced Method Of Optimized electrical TomograpHy (s-SMOOTH) based reconstruction technique to improve the spatial resolution and localization accuracy of reconstructed brain images is described. Also described is a graph Fractional-Order Total Variation (gFOTV) based reconstruction technique to improve the spatial resolution and localization accuracy of reconstructed brain images.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: June 22, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Wentai Liu, Ying Li, Jing Qin, Chi-Wei Chang, Yi-Kai Lo
  • Patent number: 11034580
    Abstract: The present invention provides stem cells loaded with bi-functional magnetic nanoparticles (nanoparticle-loaded stem cells (NLSC)) that both: a) heat in an alternating magnetic field (AMF); and b) provide MRI contrast enhancement for MR-guided hyperthermia. The nanoparticles in the NLSC are non-toxic, and do not alter stem cell proliferation and differentiation, the nanoparticles do however, become heated in an alternating magnetic field, enabling therapeutic applications for cancer treatment. Due to the fact that circulating stem cells home to tumors and metastasis, and participate in neovascularization of growing tumors, the NLSC of the present invention allows tracking of the tissue distribution of infused stem cells and selective heating of targeted tissues with AMF. NLSC can deliver hyperthermia to hypoxic areas in tumors for sensitization of those areas to subsequent treatment, thus delivering therapy to the most treatment-resistant tumor regions.
    Type: Grant
    Filed: December 25, 2019
    Date of Patent: June 15, 2021
    Inventor: Lyubov Ostrovska
  • Patent number: 11033195
    Abstract: A method and system for extracting cardiac cycle parameters from a respiration signal is disclosed. The technique comprises an array of piezoelectric sensors planted on the chest. The chest membrane exhibits the characteristics of bulky attenuator with certain time delay. Contractions and expansions of the heart and lungs muscles model a mechanical load and produce a relative induced strain on the piezoelectric sheet which in turn causes the piezoelectric material to generate a corresponding conformal voltage signal that is mapped with the heart actions. The resultant voltage signal is therefore used to extract and model the corresponding heart parameters utilizing piezoelectric as well as signal processing theories. a direct relationship is established between the output voltage produced by the piezoelectric transducer under hold breathing and the respiration signal collected by the same transducer with respiration.
    Type: Grant
    Filed: February 6, 2018
    Date of Patent: June 15, 2021
    Assignee: United Arab Emirates University
    Inventors: Mahmoud F. Y. Al Ahmad, Areen Abdallah Romi Allataifeh
  • Patent number: 11026750
    Abstract: An apparatus and method for surgical tracking comprises an imaging device that generates an image of a tissue volume; an electromagnetic (EM) sensor that creates a reference frame for EM tracking in three dimensions; at least one EM sensor adapted to be attached to the tissue to track local deformation and movement of the tissue volume; a processor that registers the image with the EM-tracked tissue volume and surgical tool in real time, and produces an output; and a feedback device that provides feedback about the location of the surgical tool relative to the tissue volume, based on the processor output. Embodiments are particularly useful in soft tissue, such as breast, where deformation before and during a procedure such as tumor resection complicate tracking of the tissue volume and a surgical tool.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: June 8, 2021
    Assignees: Queen's University at Kingston, Kingston Health Sciences Centre
    Inventors: Gabor Fichtinger, Tamas Ungi, John F. Rudan, Andras Lasso, C. Jay Engel, Gabrielle Gauvin, Caitlin Yeo
  • Patent number: 11016159
    Abstract: A method for high spatial and temporal resolution dynamic contrast enhanced magnetic resonance imaging using a random subsampled Cartesian k-space using a Poisson-disk random pattern acquisition strategy and a compressed sensing reconstruction algorithm incorporating magnitude image subtraction is presented. One reconstruction uses a split-Bregman minimization of the sum of the L1 norm of the pixel-wise magnitude difference between two successive temporal frames, a fidelity term and a total variation (TV) sparsity term.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: May 25, 2021
    Assignee: The Regents of the University of California
    Inventors: Peng Hu, Stanislas Rapacchi
  • Patent number: 11000336
    Abstract: The invention relates to an apparatus and a system for visualizing an image object relating to an instrument (3), particularly a medical instrument, in an extracorporeal image. The image object may comprise a representation of the instrument (3) or an intracorporeal image (40) acquired using the instrument (3). The system comprises an extracorporeal image acquisition device (1) for acquiring extracorporeal images with respect to an extracorporeal image frame and a tracking arrangement (2) for tracking the instrument (3) independent of the extracorporeal images with respect to a tracking frame. Further, the invention relates to a method carried out in the system.
    Type: Grant
    Filed: September 18, 2017
    Date of Patent: May 11, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Godefridus Antonius Harks, Niels Nijhof
  • Patent number: 11002816
    Abstract: The present disclosure relates to a coil assembly of an MRI device. The MRI device may be configured to perform an MR scan on a subject. The coil assembly may include one or more coil units, a substrate, and a sensor mounted within or on the substrate. The one or more coil units may be configured to receive an MR signal from the subject during the MR scan. The substrate may be configured to position the one or more coil units during the MR scan. The one or more coil units may be mounted within or on the substrate. The sensor may be configured to detect a motion signal relating to a physiological motion of the subject before or during the MR scan.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: May 11, 2021
    Assignee: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.
    Inventor: Ling Ji
  • Patent number: 10986995
    Abstract: The various embodiments described herein include methods, devices, and systems for providing ultrasound treatment to a patient. In one aspect, a method for adjusting a magnetic resonance guided focused ultrasound (MRgFUS) treatment plan with a magnetic resonance imaging (MRI) system and an ultrasound system includes: (1) identifying a location in a subject that is to receive treatment; (2) applying pulses of focused ultrasound to the identified location with the ultrasound system in order to modulate a level of naturally occurring hormones; (3) concurrently with applying the pulses of focused ultrasound, acquiring with the MRI system functional image data from the subject; (4) obtaining a series of functional images of the subject using the functional image data, the functional images indicative of the modified neuronal activity; and (5) adjusting one or more parameters of the MRgFUS treatment plan using the reconstructed series of functional images.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: April 27, 2021
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE BRIGHAM AND WOMEN'S HOSPITAL
    Inventors: Seung-Schik Yoo, Alexander Bystritsky, Nathan McDannold, Ferenc A. Jolesz
  • Patent number: 10987016
    Abstract: A system, method, and apparatus for a visualization system for deep brain stimulation. The visualization system comprises a camera system, a display system, and an information analyzer. The information analyzer is configured to display a group of electrodes for the deep brain stimulation on a head of a patient on the display system such that a visualization of the group of electrodes is displayed overlaid on the head of the patient in real time in a position corresponding to an actual position of the group of electrodes in a brain in the head of the patient. An operation of the group of electrodes sending an electrical signal into the head of the patient is displayed in the visualization, enabling visualizing a physical reaction of the patient to the deep brain stimulation in conjunction with the visualization of the operation of the group of electrodes.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: April 27, 2021
    Assignee: The Boeing Company
    Inventors: Brian Dale Laughlin, Dane Brian Laughlin, Madison Lauryn Laughlin
  • Patent number: 10970528
    Abstract: A method for human motion analysis, an apparatus for human motion analysis, a device, and a storage medium. The method includes: acquiring image information captured by a number of photographing devices, where at least one of the number of photographing devices is disposed above a shelf; performing human tracking according to the image information captured by the plurality of photographing devices, and determining position information in space of at least one human body and identification information of the at least one human body; acquiring, according to the position information in space of a target human body of the at least one human body, a target image captured by the photographing device above a shelf corresponding to the position information; and recognizing an action of the target human body according to the target image and detection data of a non-visual sensor corresponding to the position information.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: April 6, 2021
    Inventors: Jian Wang, Xubin Li, Le Kang, Zeyu Liu, Zhizhen Chi, Chengyue Zhang, Xiao Liu, Hao Sun, Shilei Wen, Yingze Bao, Mingyu Chen, Errui Ding
  • Patent number: 10966636
    Abstract: Improved cross-calibration between magnetic resonance imaging (MRI) coordinates and optical tracking coordinates is provided. Initial calibration is performed with a calibration tool that includes wireless active markers that can be tracked using the MRI scanner, and an optical marker that can be tracked using the optical tracking system. Data from one or more poses of this tool are used to provide an initial cross-calibration. In use, this initial calibration is corrected to account for differences between actual camera position and the reference location. Here the reference location is the camera location at which the initial calibration was performed.
    Type: Grant
    Filed: December 2, 2014
    Date of Patent: April 6, 2021
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Julian Maclaren, Murat Aksoy, Melvyn B. Ooi, Roland Bammer
  • Patent number: 10959656
    Abstract: Disclosed herein is a technique for observing the insular cortex activity by using electroencephalograms. A method for sampling cerebral insular cortex activity includes: recording electroencephalograms (EEGs) provided by a plurality of EEG electrodes; creating a three-dimensional model in the form of a mesh in which a subject's brain is decomposed into a plurality of sites according to the subject's brain structure and positioning the plurality of EEG electrodes by reference to an image representing the subject's brain and head structure; creating a forward model by modeling a correlation between the activities of the respective brain sites of the three-dimensional model and an electroencephalogram distribution of the positioned EEG electrodes; and associating, by reference to information about a region of interest measured by functional magnetic resonance imaging (fMRI) and the forward model, data about the electroencephalograms recorded with the cerebral activity of the region of interest.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: March 30, 2021
    Assignee: HIROSHIMA UNIVERSITY
    Inventors: Noriaki Kanayama, Kai Makita, Takashi Sasaoka, Masahiro Machizawa, Tomoya Matsumoto, Shigeto Yamawaki
  • Patent number: 10959857
    Abstract: A registration system including a bone pin guide and a bone pin clamp. The bone pin guide may include a guide body, a first guide including a first guide through-hole having a first longitudinal axis, and a second guide including a second guide through-hole having a second longitudinal axis. The bone pin guide may guide first and second bone pins into a bone via the first and second guides. The bone pin clamp may include a clamp body, first, second, and third clamp through-holes extending through the clamp body, a plurality of registration indents defined on the clamp body, and a clamping mechanism including at least one adjustable fastener. The bone pin clamp may receive the first and second bone pins in the first and third clamp through-holes and guide a third bone pin into the bone via the second clamp through-hole.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: March 30, 2021
    Assignee: MAKO Surgical Corp.
    Inventors: Zhu Wu, Sunil Gupta, Ta-Cheng Chang, Zenan Zhang, Kevin Bechtold, Matthew Thompson, Eric Branch, Varun Chandra, Ahmet Bagci
  • Patent number: 10957010
    Abstract: The subject matter discussed herein relates to the automatic, real-time registration of pre-operative magnetic resonance imaging (MRI) data to intra-operative ultrasound (US) data (e.g., reconstructed images or unreconstructed data), such as to facilitate surgical guidance or other interventional procedures. In one such example, brain structures (or other suitable anatomic features or structures) are automatically segmented in pre-operative and intra-operative ultrasound data. Thereafter, anatomic structure (e.g., brain structure) guided registration is applied between pre-operative and intra-operative ultrasound data to account for non-linear deformation of the imaged anatomic structure. MR images that are pre-registered to pre-operative ultrasound images are then given the same nonlinear spatial transformation to align the MR images with intra-operative ultrasound images to provide surgical guidance.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: March 23, 2021
    Assignee: General Electric Company
    Inventors: Soumya Ghose, Jhimli Mitra, David Martin Mills, Lowell Scott Smith, Desmond Teck Beng Yeo, Thomas Kwok-Fah Foo
  • Patent number: 10955509
    Abstract: A magnetic resonance imaging (MRI) system (100, 600) that generates information indicative of a fluid flow in accordance with a pseudo-continuous arterial spin labeling (pCASL) method. The MRI system may include at least one controller (104, 610) configured to generate a pseudo-continuous arterial spin labeling (pCASL) pulse sequence (200) including at least a first gradient (GR) pulse sequence (207) having a sinusoidal waveform including a plurality of cycles, and a second radio frequency (RF) pulse sequence (205) including a half-wave rectified sinusoidal waveform having a plurality of cycles and which is synchronous with the first GR pulse sequence; label at least part of the fluid flow in a labeling region during a labeling mode using the pCASL pulse sequence; acquire label and control image information of the fluid flow at an imaging region proximal to downstream of the labeling region; and/or generate image information in accordance with a difference of the acquired label and control image information.
    Type: Grant
    Filed: December 31, 2013
    Date of Patent: March 23, 2021
    Assignee: Koninklijke Philips N.V.
    Inventors: Michael Gunter Helle, Tim Nielsen
  • Patent number: 10926107
    Abstract: The present disclosure relates to a system and a method. The system may include a first device including a treatment head configured to emit a radiation beam. The system may include a second device comprising a body. The body may include one or more openings at a bottom of the recess that allow passage of the radiation beam substantially free of the interference by the body.
    Type: Grant
    Filed: February 17, 2020
    Date of Patent: February 23, 2021
    Assignee: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.
    Inventors: Cheng Ni, Jianfeng Liu, Xingen Yu
  • Patent number: 10925539
    Abstract: Patient headphones (50) for use in a medical scanning modality, comprising a frame member (52), two ear cups (54) that, in an operational state of the patient headphones (50), are arranged to be in contact with one of the patient's ears, and a sensor system (60), the sensor system (60) including optical emitters (64) that are configured for directing electromagnetic radiation to a portion of the patient's skin, and optical sensors (68) that are configured for receiving the electromagnetic radiation being returned from the portion of the patient's skin, and for providing an output signal that corresponds to the received electromagnetic radiation, wherein the output signal is indicative of at least one physiological parameter of the patient and serves as a basis for determining the at least one physiological parameter of the patient; —a patient headphones system (48) for use in a medical scanning modality (10), comprising an embodiment of such patient headphones (50) and a data acquisition and analysis unit (76
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: February 23, 2021
    Assignee: Koninklijke Philips N.V.
    Inventors: Christoph Leussler, Daniel Wirtz, Sascha Krueger
  • Patent number: 10921412
    Abstract: The invention provides for a medical instrument (100) comprising a processor (134) and a memory (138) containing machine executable instructions (140). Execution of the machine executable instructions causes the processor to: receive (200) a first magnetic resonance image data set (146) descriptive of a first region of interest (122) of a subject (118) and receive (202) at least one second magnetic resonance image data set (152, 152?) descriptive of a second region of interest (124) of the subject. The first region of interest at least partially comprises the second region of interest. Execution of the machine executable instructions further cause the processor to receive (204) an analysis region (126) within both the first region of interest and within the second region of interest.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: February 16, 2021
    Assignee: Koninklijke Philips N.V.
    Inventors: Fabian Wenzel, Martin Bergtholdt, Frank Olaf Thiele
  • Patent number: 10914578
    Abstract: An apparatus for determining a position and orientation of first and second rigid bodies in relation to each other. The apparatus includes a light source mounted to the first rigid body, an image sensor mounted to either the first or second rigid body and positioned in a field of light, a shadow mask mounted to either the first or second rigid body and arranged in the field of light, and a computation unit configured to calculate at least one angle by evaluating a shadow image which passes the shadow mask and is detected by the image sensor. The apparatus may include a mechanical constraint mounted to the first and second rigid bodies that defines a fixed distance between the first and second rigid bodies, is stationary in relation to one of the first or second rigid body, and is variably inclinable in relation to the other.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: February 9, 2021
    Assignee: UNIVERSITÄT BASEL
    Inventors: Philippe C. Cattin, Lorenzo Iafolla, Lilian Witthauer
  • Patent number: 10864130
    Abstract: Embodiments of the invention thus define a system and methods for moving a patient into a medical treatment/imaging apparatus. By appropriate use of relatively narrow guides, a bed can be held securely both prior to movement onto the apparatus and while on the apparatus. By use of relatively wide guides, the bed is allowed a degree of lateral play to ensure a smooth transition on to the apparatus.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: December 15, 2020
    Assignee: ELEKTA LIMITED
    Inventors: Michael Lewald, Thomas Pfitzmaier
  • Patent number: 10863960
    Abstract: According to one embodiment, apparatus includes imaging unit, generator, position specifier, direction specifier and angle setter. Imaging unit images object into which a device is inserted, from first and second direction. Generator generates first image data and second image data each corresponding to first and second direction. Position specifier specifies position of the device based on first and second image data. Direction specifier specifies moving direction of the device based on positions of the device specified by position specifier. Angle setter sets first angle corresponding to first direction and second angle corresponding to second direction in accordance with moving direction of the device.
    Type: Grant
    Filed: November 24, 2014
    Date of Patent: December 15, 2020
    Assignee: Canon Medical Systems Corporation
    Inventor: Satoru Ohishi
  • Patent number: 10856941
    Abstract: A method of performing a percutaneous multi-probe treatment includes: acquiring a scan image of an object to be treated with multi-probe percutaneous insertions; determining a first point in a region of interest (ROI) in the scan image; determining a second point at a surface of the object in the scan image; generating a reference trajectory by connecting the first point and the second point; arranging, around the first point, a number of third points corresponding to tips of probes to be inserted into the object; generating planned insertion trajectories for the probes based on the number of probes to be inserted and the reference trajectory; and causing a monitor to display superposed on the scan image, at least one of the planned insertion trajectories. The planned insertion trajectories extend in a geometric relationship to the reference trajectory and pass through the third points and through one or more second points.
    Type: Grant
    Filed: May 21, 2020
    Date of Patent: December 8, 2020
    Assignee: Canon U.S.A., Inc.
    Inventors: Devashree S. Desai, Takahisa Kato, Lydia G. Olson
  • Patent number: 10842401
    Abstract: A computer-implemented method for non-invasively identifying ablation locations in atrial tissue, can include: receiving three-dimensional imaging data representing atrial tissue of a left atrial flutter (LAFL) subject; generating a subject-specific model of the at least one of the atrial tissue from the three-dimensional imaging data; estimating tissue fiber orientations in the atrial tissue; assigning the estimated tissue fiber orientations to the subject-specific model of the atrial tissue; conducting simulations of LAFL using the subject-specific model to identify regions of slow conduction of a propagating wave within an atrial tissue region of the atrial tissue; a critical isthmus of a rotational wavefront within the atrial tissue region; or a region based on a minimum cut in a flow network; and identifying at least one ablation location in the atrial tissue region based on the identified regions of slow conduction, the critical isthmus, or the minimum cut.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: November 24, 2020
    Assignee: The Johns Hopkins University
    Inventors: Natalia A. Trayanova, Sohail Zahid, Patrick Boyle
  • Patent number: 10835623
    Abstract: Provided herein are examples of metal chelating ligands that have high affinity for manganese. The resultant metal complexes can be used as MRI contrast agents, and can be functionalized with moieties that bind to or cause relaxivity change in the presence of biochemical targets.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: November 17, 2020
    Assignee: The General Hospital Corporation
    Inventors: Eric M. Gale, Peter Caravan
  • Patent number: 10835153
    Abstract: Certain aspects relate to systems and techniques for medical instrument navigation and targeting. In one aspect, a system includes a medical instrument having an elongate body and at least one sensor, a display, a processor, and a memory storing a model of a mapped portion of a luminal network and a position of a target with respect to the model. The processor may be configured to: determine, based on data from the at least one sensor, a position and orientation of a distal end of the medical instrument with respect to the model, and cause, on at least a portion of the display, a rendering of the model, the position of the target, and the position and orientation of the distal end of the medical instrument. The rendering may be based on a viewpoint directed at the target and different from a viewpoint of the medical instrument.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: November 17, 2020
    Assignee: Auris Health, Inc.
    Inventors: Hedyeh Rafii-Tari, Prasanth Jeevan, Douglas T. Boyd, Melissa A. Teran, Alexander James Sheehy, Nicolas E. Robert, Miroslav Drahos, Jeffery D. Howard, Andrew Esbenshade Zeldis, René Ango Mambembe
  • Patent number: 10828010
    Abstract: This invention provides a technique to dynamically set an imaging parameter appropriate for observing a region of interest on an object to generate a high-quality echogram while maintaining the operability to change the position and orientation of a probe. A region-of-interest acquisition unit acquires region information that defines the region of interest. A position and orientation acquisition unit acquires position and orientation information representing the position and orientation of a probe. A parameter deciding unit obtains an imaging parameter based on the positional relationship between an imaging range decided based on the position and orientation information and the region of interest defined by the region information, and outputs the obtained imaging parameter to an imaging unit.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: November 10, 2020
    Assignee: CANON KABUSHIKI KAISHA
    Inventors: Koichiro Wanda, Takaaki Endo, Kiyohide Satoh
  • Patent number: 10806368
    Abstract: Described herein is a system and method of controlling real-time image-guided adaptive radiation treatment of at least a portion of a region of a patient. The computer-implemented method comprises obtaining a plurality of real-time image data corresponding to 2-dimensional (2D) magnetic resonance imaging (MRI) images including at least a portion of the region, performing 2D motion field estimation on the plurality of image data, approximating a 3-dimensional (3D) motion field estimation, including applying a conversion model to the 2D motion field estimation, determining at least one real-time change of at least a portion of the region based on the approximated 3D motion field estimation, and controlling the treatment of at least a portion of the region using the determined at least one change.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: October 20, 2020
    Assignee: Elekta, Inc.
    Inventor: Francois Paul George Rene Hebert
  • Patent number: 10792010
    Abstract: A tracking, and point-of-view-based imaging, device is configured for deriving a position of and a direction from, a location at a distal tip of an elongated instrument, for performing coordinate system transformation in accordance with the position and direction, and for forming, from the location and based on a result of the transformation, a local view that moves with the tip. The device can keep, with the movement, a field of view of the local view fixed but the local view otherwise in synchrony with the position and the direction. From real-time ultrasound imaging, the local view and a more overall view that includes the tip but which does not move with said tip can be displayed. The distal tip can be that of a catheter and can be outfitted with a micromanipulator for surgery aided interactively by the combination of dynamic local and overall imaging.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: October 6, 2020
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventor: Peter Waksman
  • Patent number: 10786326
    Abstract: A surgical image pickup system utilizes an adjustable lens set and a complex lens set to change the direction of the incident light emitted from the light source and the position of the surgical site on which the incident light projects. The eyepiece and the sensor have the same field of view and the same optical axis such that first image generated by the sensor and a second image generated by the eyepiece are the same. The sensor transmits the first image to the external display for display by wireless communication. By means of the foregoing configuration, the second image which doctor utilizes the eyepiece to see and the first image which the external display displays are the same, thereby facilitating the operation of surgery.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: September 29, 2020
    Assignee: National Applied Research Laboratories
    Inventors: Rui-Cian Weng, Yih-Sharng Chen, Te-I Chang, Chi-Hung Huang, Yen-Pei Lu, Yen-Song Chen, Kuan-Yin Yu
  • Patent number: 10780224
    Abstract: Methods, systems, and apparatuses for integrating medical device data are disclosed. In an example embodiment, an integration engine receives infusion therapy progress data from an infusion pump and renal failure therapy progress data from a renal failure therapy machine. The integration engine determines a plurality of different types of infusion parameters, determines a plurality of different types of renal failure therapy parameters, and causes a combination user interface to display the plurality of infusion parameters, the plurality of renal failure therapy parameters, and mathematical operations for selection by an operator. The integration engine enables the operator to create derivative data by receiving a selection of an infusion parameter, a renal failure therapy parameter, and a mathematical operation. The integration engine then causes the combination user interface to display the derivative data in conjunction with the infusion therapy progress data and the renal failure therapy progress data.
    Type: Grant
    Filed: November 11, 2019
    Date of Patent: September 22, 2020
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventor: Jonathan Alan Handler
  • Patent number: 10772532
    Abstract: A method of registering a luminal network to a 3D model of the luminal network with real-time feedback is disclosed, including generating the 3D model of the luminal network based on images of the luminal network, generating an electromagnetic field about the luminal network, inserting a location sensor into the electromagnetic field, tracking the location of the sensor within the luminal network, comparing the tracked locations of the sensor with sensors located outside of the luminal network and the portions of the 3D model representative of open space, and presenting on a user interface an indication of which portions of the luminal network have been sufficiently traversed by the sensor to register that portion of the luminal network to the 3D model.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: September 15, 2020
    Assignee: COVIDIEN LP
    Inventors: Andrew E. Brown, Elad D. Lachmanovich, Eyal Klein, Oren P. Weingarten, Alexander Y. Nepomniashchy
  • Patent number: 10761161
    Abstract: A magnetic resonance (MR) apparatus has an MR scanner that includes a basic field magnet, which defines a patient receiving zone and that has at least one superconducting coil that generates a basic magnetic field in the MR scanner. The MR scanner has a power supply controlled by at least one control computer of the MR apparatus for the purpose of providing electrical power to the superconducting coil. The power supply is arranged on, and may be fixedly mounted to, the basic field magnet or integrated into the basic field magnet.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: September 1, 2020
    Assignee: Siemens Healthcare GmbH
    Inventor: Stephan Biber
  • Patent number: 10751128
    Abstract: Systems, devices, and methods obtain an image volume; obtain a description of a surface that includes a shape of the surface, a size of the surface, and a location of the surface in the image volume, sample the image volume on the surface, thereby producing sampled surface-image data; and generate a visualization of the sampled surface-image data.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: August 25, 2020
    Assignee: Canon U.S.A., Inc.
    Inventors: Zhimin Lu, Katsuki Ishii
  • Patent number: 10751133
    Abstract: A markerless robot tracking system (10) employing a surgical RCM robot (20) including a primary revolute joint (22) rotatable about a primary rotational axis and a secondary revolute joint (22) rotatable about a secondary rotational axis. A plurality of unique landmark sets are integrated into the robot (20) with each unique landmark set including landmark(s) (30) in a fixed orientation relative to the primary rotational axis and further including additional landmark(s) (30) in a fixed orientation relative to the secondary rotational axis. The system (10) further an optical camera (41, 51) for visualizing a subset of the plurality of unique landmark sets within a camera coordinate system (43, 53), and a robot tracking controller (70) for estimating a robot pose of the surgical RCM robot (20) within the camera coordinate system (43, 53) derived from the visualization by the optical camera (41, 51) of the subset of landmark(s) within the camera coordinate system (43, 53).
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: August 25, 2020
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Grzegorz Andrzej Toporek, Aleksandra Popovic
  • Patent number: 10743938
    Abstract: Disclosed is an image registration and an augmented reality system and an augmented reality method thereof which is suitable for solving the problem of spatial localization of the temporomandibular joint (TMJ) in arthroscopic surgery. The system comprises a three-dimensional scanning model building device, a stereoscopic image photographing device, a projection device and an arithmetic unit. The three-dimensional scanning model was constructed by preoperative or intraoperative imaging of the patient, and the surface three-dimensional model constructed by the stereoscopic image photographing device was spatially aligned to remove the surface (skin layer) of the three-dimensional image to display the TMJ image. Through the calibration of the stereoscopic image photographing device and the projection device, accurate, three-dimensional TMJ image location information is projected onto the patient's body to achieve the purpose.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: August 18, 2020
    Assignee: Medicaltek Co., Ltd.
    Inventors: Yen-Yu Wang, Kai-Che Liu, Kumar Atul, Li-Hsun Chen
  • Patent number: 10743941
    Abstract: Methods and systems for performing trackerless image guided soft tissue surgery. For a patient in need of brain surgery, pre-operative preparation for a patient is performed by generating a three-dimensional textured point cloud (TPC) for the patient's scalp surface, and registering the first three-dimensional TPC to a magnetic resonance (MR) model of the brain. During the surgery, an intra-operative cortical surface registration to the MR model is performed for the MR-to-cortical surface alignment. Then shift measurement and compensation to the MR model is performed by: performing absolute deformation measurement of the brain based on the MR model with the cortical surface registration, and obtaining shift correction to the MR model using the absolute deformation measurements. The shift correction may be used for adjusting an image guidance system (IGS) in the brain surgery.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: August 18, 2020
    Assignee: VANDERBILT UNIVERSITY
    Inventor: Michael I. Miga
  • Patent number: 10736595
    Abstract: An image control system has a table, a head frame, an imaging system, a rotation system, and a control system. The head frame includes at least one pin which immobilizes a select patient anatomy with respect to the table while the imaging system collects image data through a CT scan process. The CT scan process produces an image of the patient anatomy, with the image including an artifact associated with the at least one pin. The artifact masks an area of interest in the image. The control system determines an angle of rotation which will move the artifact out of the area of interest and rotates at least one of the table, the head frame, and the imaging system by the angle of rotation. A subsequent image produced by the CT scan process includes an image of the patient anatomy with the artifact moved out of the area of interest.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: August 11, 2020
    Assignee: Siemens Healthcare GmbH
    Inventor: Julie DiNitto
  • Patent number: 10722124
    Abstract: The invention describes a method for extracting several physiological parameters such as cardiac cycle parameters with one single measurement over a time period and for monitoring mechanical and electrical cardiac activity. The invention finds its use in providing continuous monitoring of heart mechanical and electrical activities over time. Such signal may be transmitted to clinics of family doctors to keep track of the subject's health.
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: July 28, 2020
    Assignee: United Arab Emirates University
    Inventors: Mahmoud F. Y. Al Ahmad, Nabil Bastaki, Bisni Fahad Mon
  • Patent number: 10716471
    Abstract: To make it possible to improve user convenience, provided is a control device including: a control unit configured to control a position and an attitude of a microscope unit by driving an arm unit that supports the microscope unit on the basis of a captured image of an operating site photographed by the microscope unit during an operation so that a position and attitude condition set before the operation is satisfied. The position and attitude condition is a condition that prescribes a position and an attitude of the microscope unit with respect to the operating site to obtain a desired captured image corresponding to the position and attitude condition.
    Type: Grant
    Filed: December 18, 2017
    Date of Patent: July 21, 2020
    Assignee: SONY CORPORATION
    Inventors: Tomoyuki Ootsuki, Atsushi Miyamoto
  • Patent number: 10702238
    Abstract: The disclosure relates to a system and method for calibrating a medical system. The method may include one or more of the following operations. Projection data of a phantom comprising a plurality of markers may be acquired from an imaging device, at a plurality of angles of a source of the imaging device. A plurality of projection matrices of a first coordinate system relating to the phantom and a transformation matrix between the first coordinate system and a second coordinate system relating to the imaging device may be determined based on the projection data of the phantom and coordinates of the plurality of markers in the first coordinate system. A plurality of projection matrices of the second coordinate system may be determined based on the plurality of projection matrices of the first coordinate system and the transformation matrix.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: July 7, 2020
    Assignee: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.
    Inventors: Hongcheng Yang, Supratik Bose
  • Patent number: 10699434
    Abstract: A method is disclosed for determining result data based upon medical measurement data of an examination object. Within the method, a high-dimensional first parameter space is formed, in which measurement values of the various measurements are represented with the aid of value tuples. The measurement values of the various measurements are assigned to a value tuple based on their spatial arrangement in the examination object and/or on their temporal arrangement relative to one another. In the first parameter space, the value tuples are analyzed, using at least one mapping function to at least one further parameter space including a lower dimension than the first parameter space, in order to obtain result data. Furthermore, the result data is output, preferably visualized. In addition, a corresponding device for determining result data is described.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: June 30, 2020
    Assignee: SIEMENS HEALTHCARE GMBH
    Inventors: Robert Grimm, Bernd Schweizer
  • Patent number: 10695122
    Abstract: This disclosure relates to forming a lesion in a patient's neurological tissue without requiring general anesthesia. The lesion can be either temporary or permanent. In either case, the lesion can be created by a steerable probe that includes a steerable guide, a laser device, and at least one electrode. The steerable guide steers the probe to a target location in the subject's neurological tissue. When the probe reaches the target location, the laser can create the lesion. The at least one electrode can detect a progressive vanishing of neural activity from the portion of the neurological tissue due to the lesion.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: June 30, 2020
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Jorge Gonzalez-Martinez, Imad Najm, John T. Gale, Karl West
  • Patent number: 10694974
    Abstract: Example embodiments of system and method for magnetic resonance imaging (MRI) techniques for planning, real-time monitoring, control, and post-treatment assessment of high intensity focused ultrasound (HIFU) mechanical fractionation of biological material are disclosed. An adapted form of HIFU, referred to as “boiling histotripsy” (BH), can be used to cause mechanical fractionation of biological material. In contrast to conventional HIFU, which cause pure thermal ablation, BH can generate therapeutic destruction of biological tissue with a degree of control and precision that allows the process to be accurately measured and monitored in real-time as well as the outcome of the treatment can be evaluated using a variety of MRI techniques. Real-time monitoring also allow for real-time control of BH.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: June 30, 2020
    Assignees: UNIVERSITY OF WASHINGTON, KONINKLIJKE PHILIPS N.V.
    Inventors: Ari Partanen, Vera Khokhlova, Navid Farr, Donghoon Lee, Wayne Kreider, Tatiana Khokhlova, Adam Maxwell, Yak-Nam Wang, George Schade, Michael Bailey
  • Patent number: 10687784
    Abstract: A system for insertion of a surgical tool along a trajectory to a target region in a patient's tissues, under the guidance of ultrasound imaging. The system includes a hand-held robot to whose base the probe of an ultrasound system is rigidly connected. The activated platform of the hand held robot carries a surgical tool guide. The alignment of the tool guide defines the trajectory which the tool takes within the subject's body. The position of the target region seen on the ultrasound display, can be recorded, and the robot coordinate frame of reference registered thereto. The system aligns the pose of the robot such that the surgical tool is aimed directly at the target region, independently of motion of the ultrasound probe and its associated robot. An inertial measurement unit can be incorporated to provide back-up positional information if the image of the lesion is lost.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: June 23, 2020
    Assignee: MAZOR ROBOTICS LTD.
    Inventor: Moshe Shoham
  • Patent number: 10682526
    Abstract: The present disclosure discloses a device for controlling rotation of a radiotherapy equipment, for controlling rotation of at least one rotational load of the radiotherapy equipment about a rotation axis. The device and the radiotherapy equipment form a full-closed-loop structure.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: June 16, 2020
    Assignee: OUR NEW MEDICAL TECHNOLOGIES
    Inventor: Xiaojun Yue
  • Patent number: 10668300
    Abstract: Radiation treatment planning and administration can include a Monte Carlo computer simulation tool to simulate photo-generated electrons in tissue. In the simulation, electrons that have left tissue voxels and entered air voxels can be evaluated to identify electrons that are circling along a spiraling trajectory in the air voxels. After at least one full spiraling circumference or other specified distance has been traversed using a detailed electron transport model, a simpler linear ballistic motion model can be instituted. This speeds simulation while accurately accounting for spiraling electrons that re-enter tissue voxels.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: June 2, 2020
    Assignee: Elekta, Inc.
    Inventors: Sami Hissoiny, Michel Moreau
  • Patent number: 10649056
    Abstract: Embodiments can provide a computer-implemented method for free breathing three dimensional diffusion imaging, the method comprising initiating, via a k-space component processor, diffusion/T2 preparation, comprising generating diffusion contrast; and adjusting one or more of amplitude, duration, and polarity to set a first order moment; applying, via an image data processor, a stack of stars k-space ordering, comprising acquiring a radial/spiral view for all members of a plurality of partitions in a partition-encoding direction; increasing an azimuthal angle until a complete set of radial/spiral views are sampled; and applying diffusion gradients along each of three axis simultaneously; and calculating, via the image data processor, an apparent diffusion coefficient map.
    Type: Grant
    Filed: September 8, 2017
    Date of Patent: May 12, 2020
    Assignees: Siemens Healthcare GmbH, Cedars-Sinai Medical Center
    Inventors: Xiaoming Bi, Christopher T. Nguyen, Zhaoyang Fan, Yutaka Natsuaki, Debiao Li, Gerhard Laub
  • Patent number: 10639447
    Abstract: A system for monitoring anesthetic agents fill level in a vaporizer reservoir includes a camera configured to capture an image containing a sight glass on the vapor reservoir, just like, a processor, and an agent level module. The agent level module is executable to locate a sight glass portion within the image, an agent level edge within the sight glass portion, and minimum and maximum reference points within the image. A fill percentage is calculated based on a position of the agent level edge relative to the minimum and maximum reference points, and the remaining agent information is calculated based on the fill percentage and the known volume of the vaporizer reservoir.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: May 5, 2020
    Assignee: General Electric Company
    Inventors: James Hanrahan, Antti Tanner