Abstract: Systems and methods are disclosed for fabrication of custom clothing with enhanced support for a body part by digitizing a 3D-model of a person, performing anatomy detection and localization of the body part, applying force analysis to design a structure that supports the body part, and fabricating the structure.

Abstract: Systems and methods of image reconstruction are disclosed. A positron emission tomography (PET) dataset is acquired from a PET imaging modality and a magnetic resonance imaging (MRI) dataset is obtained from an MRI modality. The MRI dataset is registered to the PET dataset. An MRI reconstructed image is generated from the MRI dataset and is registered to the PET dataset. An iterative reconstruction process is applied to the PET dataset using the MRI reconstructed image as guidance. The iterative reconstruction process includes one or more similarity coefficients and a spatially variant adaptive hyperparameter is calculated for each iteration of the iterative reconstruction process. A reconstructed image is output from the iterative reconstruction process.

Abstract: A medical information processing apparatus according to an embodiment includes processing circuitry. The processing circuitry calculates noise intensity from first data acquired during a first scan. The processing circuitry calculates a denoising intensity used for a denoising process based on the noise intensity and the difference between an imaging condition for the first scan and an imaging condition for a second scan, the denoising process being applied to second data obtained by the second scan.

Abstract: An X-ray diagnosis apparatus according to an embodiment includes an imaging system and a processing circuitry. The imaging system is configured to perform an imaging process on an examined subject by emitting X-rays onto the examined subject. The processing circuitry is configured to execute the imaging process on the examined subject by controlling the imaging system in an imaging mode selected from between an X-ray fluoroscopy imaging mode for obtaining an X-ray projection fluoroscopic image of the examined subject and a Computed Tomography (CT) imaging mode for obtaining a CT image of the examined subject and is configured to perform a super resolution process corresponding to the imaging mode.

Abstract: The present disclosure is directed to a radiation therapy system. The radiation therapy system may comprise a magnetic resonance imaging (MRI) apparatus. The MRI apparatus may include a plurality of shielding magnetic coils, the plurality of shielding magnetic coils being arranged around an axis. The radiation therapy system may also comprise a radiation therapy apparatus, which includes a linear accelerator configured to accelerate electrons to produce a radiation beam, the linear accelerator being located between two neighboring shielding coils of the plurality of shielding coils, and a length direction of the linear accelerator being parallel with the axis. The radiation therapy apparatus may also include a deflection magnet configured to deflect the electrons emitted from the linear accelerator by a deflection angle in a first portion of a moving trajectory, the first portion of the moving trajectory being on a plane intersecting with a radial plane of the MRI apparatus.

Abstract: A method of analyzing a multidimensional image tensor containing a plurality of images comprises: performing imaging scans of a subject imaging data; generating the multidimensional image tensor from the imaging data; determining a spatial basis tensor containing basis images based on the multidimensional image tensor; determining a temporal basis tensor containing basis functions for a temporal dimension based on the multidimensional image tensor; determining a core tensor that relates the spatial basis tensor to the temporal basis tensor; pre-multiplying the core tensor and the temporal basis tensor to produce a modified temporal basis tensor; storing the spatial basis tensor and the modified temporal basis tensor; and generating an image by multiplying at least (i) at least a portion of the spatial basis tensor and (ii) at least a portion of the modified temporal basis tensor.

Abstract: A gradient coil assembly for a magnetic resonance imaging device is disclosed. The gradient coil assembly comprises a cylindrical carrier with conductors forming three gradient coils associated with three orthogonal physical gradient axes. The cylindrical carrier comprises at least two radial through openings at different angular positions. At least one of the conductors runs through at least one area of the carrier located circumferentially between the through openings.

Abstract: A magnetic stimulation system may include first and second subsystems. The first subsystem may include a first stimulator, a first coil, and a first processor configured to determine stimulation parameter data for a subject. The second subsystem may include a second stimulator, a headpiece including an identifier and a second coil mounted to a headpiece body at a fixed location, an image recording device, and a second processor configured to: receive first image data for one or more first images of the subject and headpiece; receive, from the image recording device, second image data for one or more second images of the subject and headpiece; determine, using the first and second image data, that the stimulation parameter data corresponds to the subject; determine, using the second image data, that the headpiece corresponds to the subject; and determine, using the second image data, that the headpiece is at a pre-determined position.

Abstract: Methods and systems that provide quantitative assessments of in vivo thermal treatments, such as ablations, during image-guided surgeries using a high-resolution pre-operative MRI image segmented with a shape constrained and deformable mesh representations of brain structures and generating 3-D visualizations of thermally treated volumes during the thermal treatment that can provide near real time visual and quantitative feedback to a clinician.

Abstract: Provided herein are methods and systems for making patient-specific therapy recommendations of a combination of any two or more therapies selected from a lipid-lowering therapy, an anti-inflammatory therapy for patients with known or suspected cardiovascular disease, such as atherosclerosis.

Abstract: Disclosed herein are systems and methods for rapidly delivering high doses of radiation, also known as, flash dose radiotherapy or flash radiotherapy. One variation of a system for flash radiotherapy has a plurality of therapeutic radiation sources on a support structure (e.g., a gantry or arm) and configured to toward a patient target region, and a controller in communication with all of the therapeutic radiation sources. The controller is configured to activate the plurality of therapeutic radiation sources simultaneously so that the patient target region rapidly receives a high dose of radiation, e.g. the entire prescribed dose of radiation. In some variations, a flash radiotherapy system has a pulsed, high-power source that may be used to generate an X-ray pulse that delivers a dose having a dose rate from about 7.5 Gy/s to about 70 Gy/s. Flash radiotherapy systems may also include one or more imaging systems mounted on the support structure.

Abstract: Provided is a method for locating a tumor. The method includes: performing image registration on a projection image of the tumor and a first standard image to acquire a first offset; generating a second standard image based on the first offset; performing image registration on the projection image and the second standard image to acquire a second offset; and updating the second standard image based on the second offset and executing the operation of image registration on the projection image and the second standard image again in response to the second offset satisfying a virtual re-sampling condition; or outputting an accumulated offset in response to the second offset not satisfying the virtual re-sampling condition, wherein the accumulated offset is a sum of the first offset and the second offset acquired by executing the operation of image registration.

Abstract: System and method for presentation of tissue sensing data being collected from a tissue being measured are presented and configured for on-line as well as for off-line presentation of the tissue sensing data, the system comprising a device configured and operable to display a graphical user interface, the graphical user interface comprises at least one observation field and is configured to be responsive to the tissue sensing data comprising one or more sensing datum of measured tissue property value, to transform each measured tissue property value into virtual representation in the at least one observation field in the form of a parametric space of two different characteristic parameters of tissue corresponding to the measured tissue property value.

Abstract: System and methods are disclosed to facilitate intra-operative procedures and planning. A method can include storing tracking data in memory, the tracking data being generated by a tracking system to represent a location of an object in a tracking coordinate system of the tracking system. The method can also include storing a patient-specific implicit model in memory, the patient-specific implicit model being generated based on image data acquired for the patient to define geometry of an anatomical structure of the patient. The method can also include registering the tracking data and the patient-specific implicit model in a common three-dimensional coordinate system. The method can also include generating an output visualization representing a location of the object relative to the geometry of the anatomical structure of the patient in the common coordinate system.

Abstract: An endoscopic imaging system for use in a light deficient environment includes an imaging device having a tube, one or more image sensors, and a lens assembly including at least one optical elements that corresponds to the one or more image sensors. The endoscopic system includes a display for a user to visualize a scene and an image signal processing controller. The endoscopic system includes a light engine having an illumination source generating one or more pulses of electromagnetic radiation and a lumen transmitting one or more pulses of electromagnetic radiation to a distal tip of an endoscope.

Abstract: An apparatus for treatment planning and/or treatment setup includes: a simulator configured to obtain a first model representing a first component of a medical system, and virtually move the first model to simulate a movement of the first component of the medical system; an analyzer configured to determine imaging waypoints during a treatment process based on the virtual movement of the first model; and a graphic generator configured to generate a graphic based on the determined imaging waypoints.

Abstract: Systems and methods for accelerated online adaptive radiation therapy (“ART”) are described. The improvements to online ART are generally provided based on the use of textural analysis and machine learning algorithms implemented with a hardware processor and a memory. The described systems and methods enable more efficient and accurate online adaptive replanning (“OLAR”), which can also be implemented in clinically acceptable timeframes. For example, OLAR can be reduced from taking 10-30 minutes down to 5-10 minutes.

Abstract: According to one embodiment, a medical information processing apparatus includes processing circuitry configured to derive an index value with respect to noise included in data associated with magnetic resonance signals collected by each of a plurality of reception coils, adjust a degree to which noise is removed from the data associated with the magnetic resonance signals based on the derived index value, remove noise from the data associated with the magnetic resonance signals based on the adjusted degree, and perform compositing of the data associated with the magnetic resonance signals from which noise has been removed.

Abstract: A catheter has single axis sensors mounted directly along a portion of the catheter whose position/location is of interest. The magnetic based, single axis sensors are on a linear or nonlinear single axis sensor (SAS) assembly. The catheter includes a catheter body and a distal 2D or 3D configuration provided by a support member on which at least one, if not at least three single axis sensors, are mounted serially along a length of the support member. The magnetic-based sensor assembly may include at least one coil member wrapped on the support member, wherein the coil member is connected via a joint region to a respective cable member adapted to transmit a signal providing location information from the coil member to a mapping and localization system. The joint region provides strain relief adaptations to the at least one coil member and the respective cable member from detaching.

Abstract: Magnetic particle actuating systems may include a magnet system configured to generate a magnetic field that includes a field-free region. A corresponding control system can be configured to control the magnet system to create a field-free region at least partially matching a target region. An excitation system can be configured to generate an excitation field to cause actuation of magnetic nanoparticles in an actuation region.

Abstract: The disclosure relates to a system for immobilizing and supporting a subject in a medical procedure. The system may include a treatment apparatus configured to generate a radiation beam, and a device for immobilizing a subject. The device may include an immobilizing component for immobilizing at least one portion of the subject, and a radio frequency (RF) coil configured to receive a magnetic resonance (MR) signal related to the at least one portion of the subject. The immobilizing component may be configured to switch between a first mode and a second mode. The first mode may correspond to a positive pressure or a constant pressure related to the device. The second mode may correspond to a space of vacuum or substantially of vacuum related to the device. The RF coil may be located in the immobilizing component according to a position where the radiation beam is incident on the device.

Abstract: A system and process is provided for dynamically positioning or repositioning a robot in a surgical context based on workspace and task requirements, manipulator requirements, or user preferences to execute a surgical plan. The system and method accurately determines and indicates an optimal position for a robot with respect to a patient's anatomy before or during a surgical procedure. Optimal positions for a robot are intuitively indicated to a user. surgical procedures can illustratively include surgery to the knee joint, hip joint, spine, shoulder joint, elbow joint, ankle joint, jaw, a tumor site, joints of the hand or foot, and other appropriate surgical sites.

Abstract: A system for visualizing catheter irrigation, the system includes a fluid container, a pump, a schlieren imaging assembly and a processor. The fluid container is configured to: (i) contain a first fluid, which is at least partially transparent and has a first temperature, and (ii) receive into the first fluid a catheter having one or more irrigation holes. The pump is configured to inject, through the one or more irrigation holes, a second fluid, which is at least partially transparent and has a second different temperature. The schlieren imaging assembly is configured to acquire schlieren images of turbulence occurring in the first fluid when injecting the second fluid, and the processor is configured to visualize the irrigation using the schlieren images.

Abstract: A radiotherapy apparatus adapted for use with a Magnetic Resonance Imaging (MRI) system, the radiotherapy apparatus comprising a linear accelerator, the linear accelerator including an electron source. In the linear accelerator electrons which are introduced by the source are accelerated to impact on a target and produce a beam of radiotherapeutic radiation. The linear accelerator has an accelerator waveguide within which the electrons are accelerated and an external waveguide enclosure; this enclosure extends substantially continuously over the accelerator waveguide.

Abstract: The purpose of the present invention is to diagnose a neurological disease such as dementia by using virtual reality, and the present invention receives a neurological disease-diagnosing problem from an external device, displays a virtual reality image through a display on the basis of the received neurological disease-diagnosing problem, and performs an examination using the virtual reality image according to user actions detected through various sensors. This process can be performed when linked with an external device such as a PC or a smart phone. Particularly, with respect to the neurological disease-diagnosing problem, the present invention includes: a first screen for introducing at least one object in a virtual reality space and hiding the same; and a second screen having a question on the hidden object. According to the present invention, neurological disease such as dementia can be conveniently examined without inconveniencing or burdening a patient.

Abstract: Determining location and orientation of a hand-held surgical tool is provided. One embodiment captures image data that includes images of a first detectable target on the hand-held surgical tool and a second detectable target on a patient. Location and orientation or the first detectable target in a 3D space is determined based on the image data. Current location and orientation of the hand-held surgical tool in the 3D space determined based on the determined location and orientation of the first detectable target and based on retrieved model data representing the hand-held surgical tool. Location of the second detectable target in the 3D space is determined based on the image data. Then, a location of the patient's tissue in the 3D space relative to the location and orientation of the hand-held surgical tool is determined based on the determined location of the patient's second detectable target.

Abstract: A deep learning (DL) convolution neural network (CNN) reduces noise in positron emission tomography (PET) images, and is trained using a range of noise levels for the low-quality images having high noise in the training dataset to produceuniform high-quality images having low noise, independently of the noise level of the input image. The DL-CNN network can be implemented by slicing a three-dimensional (3D) PET image into 2D slices along transaxial, coronal, and sagittal planes, using three separate 2D CNN networks for each respective plane, and averaging the outputs from these three separate 2D CNN networks. Feature-oriented training can be implemented by segmenting each training image into lesion and background regions, and, in the loss function, applying greater weights to voxels in the lesion region. Other medical images (e.g. MRI and CT) can be used to enhance resolution of the PET images and provide partial volume corrections.

Abstract: The purpose of the present invention is to diagnose a neurological disease such as dementia by using virtual reality, and the present invention receives a neurological disease-diagnosing problem from an external device, displays a virtual reality image through a display on the basis of the received neurological disease-diagnosing problem, and performs an examination using the virtual reality image according to user actions detected through various sensors. This process can be performed when linked with an external device such as a PC or a smart phone. Particularly, with respect to the neurological disease-diagnosing problem, the present invention includes: a first screen for introducing at least one object in a virtual reality space and hiding the same; and a second screen having a question on the hidden object. According to the present invention, neurological disease such as dementia can be conveniently examined without inconveniencing or burdening a patient.

Abstract: A computer-implemented method for provision of a result dataset having position information of a local radio-frequency coil, including: providing input data having at least magnetic resonance data, which is acquired by means of the local radio-frequency coil; determining a result dataset by applying a trained function to the input data, wherein the result dataset comprises position information for determining the position of the local radio-frequency coil; and providing the result dataset.

Abstract: A high-energy radiation treatment system can comprise a laser-driven accelerator system, a patient monitoring system, and a control system. The laser-driven accelerator system, such as a laser-driven plasma accelerator or a laser-driven dielectric microstructure accelerator, can be constructed to irradiate a patient disposed on a patient support. The patient monitoring system can be configured to detect and track a location or movement of a treatment volume within the patient. The control system can be configured to control the laser-driven accelerator system responsively to the location or movement of the treatment volume. The system can also include a beam control system, which generates a magnetic field that can affect the radiation beam and/or secondary electrons produced by the irradiation beam. In some embodiments, the beam control system and the patient monitoring system can comprise a magnetic resonance imaging system.

Abstract: An ultrasound cardiac stimulation system includes: a system for measuring the heart electrical activity; a system for generating a beam of focussed ultrasound signals focussed on a targeted zone, the signals being calibrated to generate electrical stimulation in a zone of the heart, the beam generation being synchronised with a first selected time of the electrocardiogram, the generation of the beam corresponding to a pulse with a duration of less than 80 ms; a system for locating the targeted zone coupled with a system for positioning the system for generating the focussed beam to control the beam of focussed ultrasound signals in the targeted zone, the location system being synchronised with the system for generating the beam of focussed signals; a single monitoring system following in real time a temperature and tissue deformation in the targeted zone, the monitoring system taking measurements in synchronisation with the rhythm of the electrocardiogram.

Abstract: A method of generating a color image using a monochromatic image sensor. The method includes sequentially illuminating a surface in a plurality of colors, one color at a time. The monochromatic image sensor captures a plurality of image frames of the surface based on the plurality of colors. The plurality of image frames are identified, and at least one feature in the target of the plurality of image frames is highlighted. Color intensities of the plurality of image frames are normalized. A color intensity map of the target for each of the plurality of image frames is generated. A correlation score is determined by comparing each color intensity map of the plurality of image frames. The color image is generated based on the correlation score.

Abstract: An information processing apparatus according to an embodiment of the present disclosure includes a processing circuitry. The processing circuitry obtains a first g factor generated by using first magnetic resonance data acquired through a first parallel imaging process performed by using a plurality of reception coils and a second g factor generated by using second magnetic resonance data related to a second parallel imaging process performed by using the plurality of reception coils. The second parallel imaging process is different from the first parallel imaging process. The processing circuitry adjusts the first g factor so as to reduce a difference between the first g factor and the second g factor.

Abstract: An ultrasound probe for percutaneous insertion into an incision and related methods are disclosed herein, e.g., for imaging neural structures at a surgical site of a patient. An exemplary ultrasound probe can be a portable ultrasound probe configured to be passed percutaneously into an incision and can have an imaging region extending distally from a distal tip of the probe. In one embodiment the ultrasound probe can be a navigated portable ultrasound probe. The ultrasound probe can be connected to a computing station and configured to transmit images to the computing station for processing. In another embodiment, an ultrasound probe can be part of a network of sensors, including at least one external sensor, where the network of sensors is configured to transmit images to the computing station for processing. The computing station can process and display images to visualize and/or highlight neurological structures in an imaged region.

Abstract: A system for surgical planning and assessment of spinal pathology or spinal deformity correction in a subject, the system comprises a control unit configured to align one or more vertebral bodies of a biomechanical model to one or more vertebral bodies of the radiograph. The control unit is configured to receive one or more spinal correction inputs. The control unit is configured to, based on the received one or more spinal correction inputs, simulate the biomechanical model in a predetermined posture. The control unit is configured to provide for display one or more characteristics of the simulated biomechanical model.

Abstract: The present invention relates to a radiotherapy apparatus and a method for determining target positions using a radiotherapy apparatus, so as to accurately detect the motion of the tumor position.

Abstract: Provided herein are methods for analyzing in vivo a brain circuit. A method of the present disclosure may include using optogenetics to stimulate a first region of a brain of an individual, in conjunction with functional magnetic resonance imaging (fMRI) of different regions of the brain to determine a dynamic functional connection between individual neurons of the first region and a second region of the brain. The method may further include identifying a third region of the brain, the neurons of which region mediate the dynamic functional connection between the first and second regions.

Abstract: The invention provides a method of medical imaging. The method comprises: receiving, for a current active time window (204A-N) and during a brain activity analysis session (200, 500), fMRI data of a region of interest (309) of a subject (318) in an active state. A transverse relaxation, T2*, map may be generated from the fMRI data using a predefined model of fMRI data variations. The generated T2* map may be compared with a reference T2* map. A blood-oxygen-level dependent (BOLD) response of the region of interest (309) during the current active time window (204 A-N) may be estimated using the results of the comparison.

Abstract: Aspects of the present disclosure relate to systems and methods for medical imaging that incorporate prior knowledge. Some aspects relate to incorporating prior knowledge using a non-local means filter. Some aspects relate to incorporating prior knowledge for improved perfusion imaging, such as those incorporating arterial spin labeling.

Abstract: Provided in accordance with the present disclosure are systems for identifying a position of target tissue relative to surgical tools using a structured light detector. An exemplary system includes antennas configured to interact with a marker placed proximate target tissue inside a patient's body, a structured light pattern source, a structured light detector, a display device, and a computing device configured to receive data from the antennas indicating interacting with the marker, determine a distance between the antennas and the marker, cause the structured light pattern source to project and detect a pattern onto the antennas. The instructions may further cause the computing device to determine, a pose of the antennas, determine, based on the determined distance between the antennas and the marker, and the determined pose of the antennas, a position of the marker relative to the antennas, and display the position of the marker relative to the antennas.

Abstract: Systems and methods relate to multi-modal imaging of tissue combined with highly focused radiation interventions. The system is a portable multimodal imaging unit that integrates imaging and image analysis. The system can be retrofitted to use with any commercial radiation therapy machine. In one aspect, a system integrates various imaging modalities into a single, coordinated structure. The system integrates X-ray and cone beam computed tomography (CBCT), optical imaging (such as bioluminescent imaging (BLI), fluorescence tomography (FT)), and positron emission tomography (PET) imaging in a single, self-contained structure.

Abstract: A camera tracking system is disclosed for computer assisted navigation during surgery. The camera tracking system is configured to identify a reference array tracked by a set of tracking cameras attached to an extended reality (XR) headset, and determine whether the reference array is registered as being paired with characteristics of one of a plurality of surgical tools defined in a surgical tool database. The camera tracking system is further configured to, based on the reference array being determined to not be registered and receiving user input, register the reference array to be paired with characteristics of one of the plurality of surgical tools selected based on the user input. The camera tracking system is further configured to provide a representation of the characteristics to a display device of the XR headset for display to the user.

Abstract: According to various embodiments, there is provided a device including a processor configured to control a robotic system to autonomously position a transducer at a plurality of locations adjacent a subject's skull and to autonomously locate a window on the subject's skull within which an artery can be located, from which artery a signal can be returned to the transducer, the signal having an energy level exceeding a predefined threshold.

Abstract: Provided are a disease region extraction apparatus, a disease region extraction method, and a disease region extraction program that can extract an infarction region even in an image in which it is difficult to prepare a large amount of data indicating a correct infarction region. A disease region extraction apparatus includes: an image acquisition unit that acquires a first image obtained by capturing an image of a subject that has developed a disease; an estimated image derivation unit that estimates a second image, whose type is different from the type of the first image, from the first image to derive an estimated image; and a disease region extraction unit that extracts a disease region from the estimated image.

Abstract: Aspects of the present disclosure describe systems, methods, and structures for patient medication adherence.

Abstract: A method for analyzing biological-tissue image includes following steps. A plurality of biological-tissue images are provided, and each of the biological-tissue images includes a plurality of target object image blocks. An image pre-processing step is performed so as to obtain a plurality of processed biological-tissue images. A fitting step is performed so as to obtain a plurality of object fitting images of the target object image blocks. A sampling step is performed, wherein a target region of each of the processed biological-tissue images is selected, and the target region includes the object fitting images. A calculating and analyzing step is performed so as to obtain an analysis result of a target regional center of the biological-tissue images.

Abstract: An embodiment of the present utility model relates to a balun assembly, including: an outer conductive tube body disposed around an electrical cable, the outer conductive tube body including a first portion and a second portion detachably connected to each other; a conductive connection member electrically connecting the outer conductive tube body to the electrical cable; and an insulative material disposed between the outer conductive tube body and the electrical cable. An embodiment of the present utility model further relates to a magnetic resonance device including the balun assembly.

Abstract: A magnetic stimulation system may include first and second subsystems. The first subsystem may include a first stimulator, a first coil, and a first processor configured to determine stimulation parameter data for a subject. The second subsystem may include a second stimulator, a headpiece including an identifier and a second coil mounted to a headpiece body at a fixed location, an image recording device, and a second processor configured to: receive first image data for one or more first images of the subject and headpiece; receive, from the image recording device, second image data for one or more second images of the subject and headpiece; determine, using the first and second image data, that the stimulation parameter data corresponds to the subject; determine, using the second image data, that the headpiece corresponds to the subject; and determine, using the second image data, that the headpiece is at a pre-determined position.

Abstract: Systems and methods for imaging. An external device may be used to acquire optical image data of a subject. One or more physical parameters of the subject may be determined based on the optical image data. The one or more physical parameters may be translated to one or more properties of the subject. The one or more properties may then be used to generate medical image data of the subject.

Abstract: A local coil for a magnetic resonance tomography scanner has an antenna. The antenna has a conductor loop and a plurality of electronic function groups, which are arranged in a distributed manner spaced apart from one another along the conductor loop and are electrically connected to one another by flexible conductor segments.