Abstract: Embodiments disclose a real-time surgery method and apparatus for displaying a stereoscopic augmented view of a patient from a static or dynamic viewpoint of the surgeon, which employs real-time three-dimensional surface reconstruction for preoperative and intraoperative image registration. Stereoscopic cameras provide real-time images of the scene including the patient. A stereoscopic video display is used by the surgeon, who sees a graphical representation of the preoperative or intraoperative images blended with the video images in a stereoscopic manner through a see through display.

Abstract: A device for alternating examination of a measurement object (170) by means of MPI and MRI with two magnetic field-generating elements is presented. The device is characterized by a main magnet coil system with two coaxial partial coil systems (100a1, 100a2; 100b2, 100b1) arranged mirror-symmetrically relative to a central plane running perpendicularly to the z-axis through the first volume under investigation (162). The volumes under investigation are superimposed. A polarity reversal device (190) reverses the polarity of the current through a partial coil system and the main magnet coil system generates a homogeneous magnetic field of at least sixth order in the first volume under investigation when the partial coil systems have identical polarity, and a spatially strongly varying magnetic field profile in the second volume under investigation when the polarities are opposite. Repositioning of the measurement object is thereby simplified or can even be eliminated.

Abstract: A catheter treatment apparatus comprises an elongate tubular member and an expandable support. The expandable support comprises a radioactive substance to treat cancerous tissue and is configured to expand from a narrow profile for insertion to a wide profile to engage and treat tissue remaining after resection. The expandable support can be sized to fit within a volume of removed tissue to place the radioactive substance in proximity to the capsule and remaining tissue, to spare the capsule and proximate nerves and vessels to treat tissue in proximity to the capsule. The elongate tubular member may comprise a channel such as a lumen to pass a bodily fluid such as urine when the expandable support engages the tissue to treat the patient for a plurality of days. The treatment apparatus can be used to resect and diagnose tissue concurrently. Based on the diagnosis, targeted segmental treatment may be given.

Abstract: A therapeutic apparatus comprising: a magnetic resonance imaging system adapted for acquiring a set of magnetic resonance imaging data in an imaging zone, wherein the magnetic resonance imaging system comprises a means for generating a magnetic field, a guiding means adapted for guiding a beam of charged particles to a target zone within a subject such that the beam encloses an angle with the magnetic field lines of the magnetic field within the imaging zone, the angle being between 0 degrees and 30 degrees, wherein the imaging zone comprises the target zone, a zone determination means for determining the location of the target zone within the subject using the set of magnetic resonance imaging data.

Abstract: A medical navigation system is provided for registering a patient for a medical procedure with the medical navigation system using fiducial markers. The fiducial markers are placed on the patient prior to a 3D scan and the fiducial markers each have a target for use with a tracking system. The medical navigation system comprises a 3D scanner, a tracking system, a display, and a controller electrically coupled to the 3D scanner, the tracking system, and the display. The controller has a processor coupled to a memory.

Abstract: Devices and methods provide for measuring applied pressure on an article, such as a patella construct during a surgical procedure. Embodiments include a clamp having an upper frame arm, a lower frame arm and a clamp assembly, and further include a clamp with a knob assembly and a pressure monitor assembly. Differently sized bushing adapters can be interchangeably employed with a clamp stem to adapt to the relative sizes of objects being clamped.

Abstract: Disclosed is a low fly height in-plane magnetic image sensor chip. This sensor chip comprises a silicon (Si) substrate with a pit on the surface, a magnetoresistive sensor, and an insulating layer. The magnetoresistive sensor is located on the bottom surface of the pit in the Si substrate. The insulating layer is located above the magnetoresistive sensor. The magnetic image surface detected during operation is coplanar or parallel with the surface of the Si substrate surface. The input and output ends of the magnetoresistive sensor are connected with leads directly, or bonded with leads through pads, or through a conducting post and pads to form connections. And the flying height of the leads is lower than the height of the surface of the Si substrate. This technical solution has several advantages, such as compact structure, high output signal, and direct contact with the magnetic image.

Abstract: In beta emission imaging, magnetic lensing allows a lower resolution detector to detect the spatial distribution of emissions at a higher resolution. The sample is placed in a magnetic field with field lines at a given density, and the detector is placed away from the sample where the magnet field lines diverge, resulting in a lesser density. Since the beta emissions travel along the field lines, the divergence of the field lines from the sample to the detector result in lensing or magnification. Using positron attenuation tomography to detect annihilation in the detector allows for correction due to self-absorption by the sample. The correction and lensing are used together or may be used independently.

Abstract: A magnetic resonance image is generated by executing a scan sequence that is determined by at least one scan parameter. A first value of the at least one scan parameter is determined for a first subregion of an examination region, and a second value of the at least one scan parameter is determined for a second subregion of the examination region. The determination of the first value and the determination of the second value is implemented so that a value of a physical variable influenced by the first value and the second value of the at least one scan parameter does not transgress a pre-set threshold value. Subsequently, the scan sequence is executed by a magnetic resonance scanner and a magnetic resonance image is generated. The threshold value can be based, for example, on technical efficiency of the scanner and/or a physiological limitation of an examination object.

Abstract: Embodiments disclose a real-time surgery method and apparatus for displaying a stereoscopic augmented view of a patient from a static or dynamic viewpoint of the surgeon, which employs real-time three-dimensional surface reconstruction for preoperative and intraoperative image registration. Stereoscopic cameras provide real-time images of the scene including the patient. A stereoscopic video display is used by the surgeon, who sees a graphical representation of the preoperative or intraoperative images blended with the video images in a stereoscopic manner through a see through display.

Abstract: In one aspect, an ultrasound receive beamformer is configured for one-way only beamforming of transmissive ultrasound using one-way delays. The receive beamforming in some embodiments is used to track, in real time, a catheter, needle or other surgical tool within an image of a region of interest. The tool can have embedded at its tip a small ultrasound transmitter or receiver for transmitting or receiving the transmissive ultrasound. Optionally, additional transducers are fixed along the tool to provide the orientation of the tool.

Abstract: An ultrasound system includes a 3D imaging probe and a needle guide which attaches to the probe for guidance of the insertion of multiple needles into a volumetric region which can be scanned by the 3D imaging probe. The needle guide responds to the insertion of a needle through the guide by identifying a plane for scanning by the probe which is the insertion plane through which the needle will pass during insertion. The orientation of the insertion plane is communicated to the probe to cause the probe to scan the identified plane and produce images of the needle as it travels through the insertion plane.

Abstract: A system and method for providing treatment feedback for a thermal treatment device (100) is provided. In certain embodiments, a thermal transmitter (120) is configured to apply an amount of thermal energy (104) to a target site (106), the thermal energy having a selected frequency and a selected power level for penetration to a depth beneath the surface of the skin. A thermal imager (140) is also provided, the thermal imager (140) being configured to capture thermal data and thermal images of the target site. The device may further provide a thermal display (160) configured to display the thermal images and thermal data, providing feedback to a user (201).

Abstract: An RF coil includes a puncture needle insertion assembly in which a plurality of holes into which a puncture needle is inserted are formed within a surface of the puncture needle insertion assembly. In the puncture needle insertion assembly, conductors of a plurality of elements of a coil that are being insulated from one another are laid to meander on a frame between the holes.

Abstract: A method and system for providing lesion depth feedback during an ablation procedure. In particular, the method and system provide feedback data or information relating to lesion depth in myocardial tissue during a cryoablation procedure. A plurality of tissue temperature measurements may be transmitted from a plurality of thermocouples disposed on a cryotreatment element, which measurements may be used to determine a slope of change in temperature sensed by each thermocouple over time. The circulation of coolant through the treatment element may be adjusted when the slope changes. A change in slope may indicate that the cryoablation temperatures have passed through target myocardial tissue into non-target, non-myocardial tissue, which may result in collateral damage to structures near the heart.

Abstract: A measurement device for magnetic resonance applications includes, in a measurement case: a first sensor for measuring radiofrequency magnetic fields; a second sensor for measuring magnetic field gradients; and a third sensor for measuring the radiofrequency electric field; and a stage for converting the electric signals delivered by the different measurement sensors into light signals. The device also in a controller for controlling and processing the signals, connected to the stage for conditioning the measurement case via a beam for transmitting light signals. The controller includes a stage for converting light signals into electric signals delivered by the sensors.

Abstract: The disclosure provides improvements of resolution and contrast in the field of x-ray imaging by using a line emitting, quasi-monochromatic x-ray source for x-ray fluorescence computed tomography. A particular type of x-ray source suitable for this is a line emitting liquid-jet-anode x-ray source. X-ray fluorescence is obtained using nanoparticles, preferably coated nanoparticles with a metallic core. The x-ray radiation from the x-ray source is shaped and filtered using energy dispersive optics before being delivered to the nanoparticles.

Abstract: The invention relates to an assistive device for positioning a medical instrument (2) inserted into a natural duct (100) or an artificial duct of a patient relative to an internal organ (P) of a patient, wherein the device comprises a support (1) that is to be inserted at least in part into the body of the patient and supports the medical instrument, means for moving the support, wherein said movement means comprise an articulated arm (9) that includes a plurality of degrees of freedom for moving a proximal end (1a) of the support, means for acquiring images of the internal organ for positioning the medical instrument relative to the internal organ, wherein the image acquisition means comprise a probe (5) supported by the support such that the medical instrument and the probe are rigidly connected, and a control unit (10) for controlling the movement means, which is connected to the image acquisition means and comprises image analyzing means (11) for generating control commands for the articulated arm in orde

Abstract: A method of fusing ultrasound images with pre-acquired images includes acquiring a first 3D ultrasound image in real-time; identifying at least one known reference pattern or object within a pre-acquired 3D image and the 3D ultrasound image; registering the real-time 3D ultrasound image with the pre-acquired 3D image by using the reference pattern or object; fusing the 3D ultrasound images of a sequence of real-time 3D ultrasound images; with the pre-acquired 3D image using data of the co-registration; and displaying fusion tomographic images, each including the corresponding real-time ultrasound image and the pre-acquired image. The registration between real-time 3D ultrasound images and the pre-acquired 3D image is performed continuously in the background by continuing to acquire the real-time 3D ultrasound images and to register them with the pre-acquired 3D images using the reference pattern or patterns or the object or objects.

Abstract: In a method and apparatus for magnetic resonance imaging, an inverse recovery pulse is emitted and execution of an image acquisition sequence wherein, magnetic resonance image data are received is begun after a delayed recovery time of the inverse recovery pulse. A magnetic resonance image is reconstructed from the acquired magnetic resonance image data. The longitudinal relaxation time is obtained based on a known time after the inverse recovery pulse and a magnetization quantity of the known time. A second relaxation time is thereby able to be fully taken into account, so as to avoid a deviation of the longitudinal relaxation time. The range of application of the Look-Locker method is expanded, so that the present invention obtains an accurate longitudinal relaxation time no matter whether a delay exists before a sampled sequence.

Abstract: The invention relates to a data processing method of determining a positional transformation (T, M) for correcting the registration of an anatomical body part with a medical imaging apparatus, the method being executed by a computer and comprising the following steps: a) acquiring initial body part position data comprising initial body part position information describing an initial relative position (1) between the medical imaging apparatus and the anatomical body part; b) acquiring, from the medical imaging apparatus, body part medical image data comprising body part medical image information describing an image of the anatomical body part; c) acquiring, based on the body part medical imaging data, actual body part position data comprising actual body part position information describing an actual relative position (2, 4) between the anatomical body part and the medical imaging apparatus; d) determining, based on the actual body part position data and the initial body part position data, body part position

Abstract: In beta emission imaging, magnetic lensing allows a lower resolution detector to detect the spatial distribution of emissions at a higher resolution. The sample is placed in a magnetic field with field lines at a given density, and the detector is placed away from the sample where the magnet field lines diverge, resulting in a lesser density. Since the beta emissions travel along the field lines, the divergence of the field lines from the sample to the detector result in lensing or magnification. Using positron attenuation tomography to detect annihilation in the detector allows for correction due to self-absorption by the sample. The correction and lensing are used together or may be used independently.

Abstract: In a method and a magnetic resonance apparatus for generating at least two parallel two-dimensional image data sets of an examination object a multi-coil array radiates a multiband radiofrequency pulse that excites at least two slices, which are phase encoded by a phase encoding gradient. Scan signals produced by the excited slices are detected using each coil of the multi-coil array. In one of the excitation or the phase encoding, the phase of the scan signal in at least one slice is modulated such that the phase of the scan signal therefrom differs from the phase of the other slices. Image data sets are reconstructed based on the modulation of the phase of the scan signal in at least one slice.

Abstract: Provided herein are systems, devices, assemblies, and methods for localization of a tag in a tissue of a patient. For example, provided herein are systems, devices, and methods employing an implantable tag that emits sidebands at defined frequencies upon activation by a magnetic field generated by a remote activating device, and a plurality of witness stations configured to detect such sidebands. Also provided herein are herein are systems, devices, and methods employing a detection component that is attached to or integrated with a surgical device.

Abstract: A radiation system includes a radiation source having an accelerator, the radiation source having a magnetic field associated therewith that is resulted from an operation of the accelerator, and a magnetic field source configured to provide a compensating magnetic field to at least partially counteract against the magnetic field that is resulted from the operation of the accelerator. A radiation system includes a radiation device having a radiation source, a patient support, and a protective guard located between the radiation source and the patient support, wherein the protective guard is moveably coupled to the radiation device or the patient support. A radiation system includes a particle generator for generating a particle, an accelerator for accelerating the particle, and a magnetic source for changing a trajectory of the particle, wherein the magnetic source comprises a permanent magnet.

Abstract: The present disclosure relates to a transfer table assembly suitable for use in association with an MR scanner. The transfer table assembly includes a transfer table attached to a transfer table base that may releasably engage an incubator. The transfer table may be dimensionally constructed such that it may be inserted directly into an MR scanner.

Abstract: A medical apparatus (1100) comprising a magnetic resonance imaging system and an interventional device (300) comprising a shaft (302, 1014, 1120). The medical apparatus further comprises a toroidal magnetic resonance fiducial marker (306, 600, 800, 900, 1000, 1122) attached to the shaft. The shaft passes through a center point (610, 810, 908, 1006) of the fiducial marker. The medical apparatus further comprises machine executable instructions (1150, 1152, 1154, 1156, 1158) for execution by a processor. The instructions cause the processor to acquire (100, 200) magnetic resonance data, to reconstruct (102, 202) a magnetic resonance image (1142), and to receive (104, 204) the selection of a target volume (1118, 1144, 1168). The instructions further cause the processor to repeatedly: acquire (106, 206) magnetic resonance location data (1146) from the fiducial marker and render (108, 212) a view (1148, 1162) indicating the position of the shaft relative to the target zone.

Abstract: Disclosed herein are devices and methods of percutaneously treating an ulcerated wound using ultrasonic energy. Some methods include delivering ultrasonic energy to a target tissue located at a position subcutaneous to the ulcerated wound. In some methods, the ultrasonic energy is delivered using an ultrasonic energy delivery device.

Abstract: System and method for presenting magnified images locked onto object of interest in operator environment. A camera disposed on head of operator captures images of scene, where camera moves in conjunction with head movements. A head tracker detects the operator LOS by detecting at least head orientation. A processor obtains designated coordinates of object of interest in scene, and determines relative angle between detected operator LOS and object. The processor determines coordinates of object in acquired images, and applies image processing for fine stabilization of images based on previous images so as to compensate for operator head movements. The processor rescales an image region surrounding object of interest, in accordance with at least one display parameter, to produce respective magnified image frames of object. A head-mounted display displays the magnified images to operator such that object of interest appears in a defined position on display regardless of operator head movements.

Abstract: A first 3D image and a second 3D image imaged a target organ in different phases of respiration are acquired. A 3D deformation model of the target organ which is stored in advance and represents nonlinear 3D deformation of the target organ due to respiration, and which has been generated based on information about movement of the target organ due to respiration of plural patients, is read. The positions of pixels on the second 3D image representing the same positions on the target organ as plural sampled pixels in a target organ region on the first 3D image are estimated using displacement due to changes in phase of points on the 3D deformation model corresponding to the positions on the target organ represented by the pixels. Non-rigid alignment is performed between the first 3D image and the second 3D image using the estimated positions of the pixels.

Abstract: In order to increase the accuracy of registration between a world coordinate system and an image coordinate system such that a tracked medical tool may be moved forward in the body of a patient without any additional or with limited live imaging, a method for registration of the tracked medical tool with an X-ray system is provided. The method includes receiving image data from the X-ray system at a plurality of time points, receiving tracking data from a tracking device of the tracked medical tool at the plurality of time points, and registering the world coordinate system and the image coordinate system based on the received image data and the received tracking data at the plurality of time points.

Abstract: According to an embodiment, a hearing aid comprising a custom-fit ear mold is disclosed. The custom fit ear mold includes a retention part comprising a structure adapted to lock anatomically with at least one point at a surface of the pinna and/or ear canal when the custom-fit earmold is positioned in the pinna and/or ear canal of the user. The at least one point represents at least one retention point selected from the plurality of retention possibility points (RPPs), wherein each RPP of the plurality of the RPPs comprises a point wherein a normal, at the RPP, to a tangent plane containing the RPP intersects at another point at surface of the pinna and/or ear canal such that the another point is proximal to a tympanic membrane of the user compared to position of the RPP relative to the tympanic membrane.

Abstract: In one example, a method includes delivering, via one or more stimulation generators of a medical device implanted in a patient, electrical stimulation to the patient. In this example, the method also includes disturbing, by one or more components of the medical device, an image of the patient generated by a magnetic resonance image (MRI) scanner.

Abstract: A method of detecting liquid in animal tissue is disclosed. The method comprises providing an electromagnetic radiation generator, and applying electromagnetic radiation to a tissue region using the electromagnetic radiation generator. The characteristics of the electromagnetic radiation are selected so as to cause differential heating in a tissue region based on liquid content in the tissue region, differential expansion of matter in the tissue region, and thereby generation of ultrasound signals that vary according to the liquid content. The method also comprises providing an ultrasound detector, detecting the ultrasound signals using the ultrasound detector, and using the detected ultrasound signals to produce an indication of concentration of liquid in the tissue region and a determination as to whether a change in liquid concentration in the tissue region has occurred.

Abstract: Optical wave guide panel for visualization of an image, wherein the panel has an image interface surface for interfacing with an image to be visually presented and a viewing interface surface opposite the image interface surface for reviewing the image located at the image interface surface. The panel has at least one boundary, and is fabricated from a transparent solid material. The panel is provided with a pattern of grooves and to the image interface surface, extending at lease partially into the panel between image interface surface and the viewing interface surface of the panel. The pattern of grooves comprises at least one groove following a contour of the at least one boundary of the panel.

Abstract: A method for determining the position of at least one ferromagnetic particle (30) in a liquid matrix (31) with an MRI system (50). An MRI measurement sequence (MS1, MS2) is applied (20) to a measurement volume (52) in which the particle is situated. The measurement sequence includes a plurality of individual measurements (E1, E2), during each of which there is a spatially encoding gradient switching operation, including an excitation pulse (1) and signal recording (2), via the MRI system. The measurement sequence has a multiplicity of measurement blocks (MB1, MB2), which each include one or more individual measurements and, in a pause of the spatial encoding, an intermediate gradient (ZW) switched by the MRI system. The intermediate gradients are dimensioned such that, averaged over time, the particle is kept substantially in the same position (M1, M2) over each measurement block.

Abstract: A method of therapy for a tumor or other pathology by administering a combination of thermotherapy and immunotherapy optionally combined with gene delivery. The combination therapy beneficially treats the tumor and prevents tumor recurrence, either locally or at a different site, by boosting the patient's immune response both at the time or original therapy and/or for later therapy. With respect to gene delivery, the inventive method may be used in cancer therapy, but is not limited to such use; it will be appreciated that the inventive method may be used for gene delivery in general. The controlled and precise application of thermal energy enhances gene transfer to any cell, whether the cell is a neoplastic cell, a pre-neoplastic cell, or a normal cell.

Abstract: There is provided a technique for obtaining temperature information for inside of a living body and accuracy information thereof in short time with low burden imposed on a subject. It is realized with a spectrum calculator configured to perform MRS or MRSI measurement for two kinds of substances showing difference of resonant frequencies and calculating spectra of magnetic resonance signals of the two kinds of substances, a temperature information calculator configured to calculate temperature information for inside of the subject on the basis of peaks of the calculated spectra, a temperature accuracy information calculator configured to calculate temperature accuracy information indicating accuracy of the temperature information on the basis of peaks of the calculated spectra, and a display information generator configured to generate display information to be displayed on a display device on the basis of the temperature information and the temperature accuracy information.

Abstract: A radiotherapy equipment control device acquires reference position information for a specific location at a reference time. Furthermore, representative point reference position information is generated from reference position information for a plurality of markers at the reference time, and relative position information up to the reference position information for the specific location is generated. Moreover, representative point position information at another time is generated from the position information for a plurality of markers in a subject at the other time, which differs from the reference time. In addition, position information for the specific location at the other time is generated from the representative point position information and the relative position information.

Abstract: A system, method, and storage device storing computer executable instructions for use in tissue analysis and therapy. A motorized optical probe for illuminating tissue generates light fluorescence and/or diffuse reflectance signals corresponding to the illuminated tissue. One or more ultrasound, CT and MRI imaging guidance systems identify the position of the optical probes relative to the tissue. An imaging system generates a three-dimensional image of the tissue based on the generated light signals and the identified position of the optical probe.

Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.

Abstract: In a method and apparatus for magnetic resonance imaging, in order to create a T1 map, an pulse sequence is used that includes at least one exposure cycle, wherein the exposure cycle includes an inversion pulse, a saturation pulse quantity of one or more saturation pulses and a readout step quantity of one or more readout steps. Within the exposure cycle, at least one saturation pulse of the saturation pulse quantity follows the inversion pulse and at least one readout step of the readout step quantity follows the at least one saturation pulse.

Abstract: A magnetic resonance imaging apparatus according to an embodiment includes a controller and a generator. The controller divides a plurality of slice regions that are sequentially arranged into a first group including two non-sequential slice regions and a second group including a slice region positioned between the two non-sequential slice regions and acquires data from the slice regions for each of the groups. When acquiring data from at least one of the two non-sequential slice regions, the controller acquires the data after applying a pre-sat pulse to a position between the two non-sequential slice regions. When acquiring data from the slice region positioned between the two non-sequential slice regions, the controller acquires the data after applying a pre-sat pulse to a position of at least one of the two non-sequential slice regions.

Abstract: Arterial spin labelling (ASL) MRI offers a non-invasive means to create blood-borne contrast in vivo for dynamic angiographic imaging. By spatial modulation of the ASL process it is possible to uniquely label individual arteries over a series of measurements, allowing each to be separately identified in the resulting images. This separation requires appropriate analysis for which a general framework has previously been proposed. Here the general framework is modified for fast analysis of non-invasive imaging of blood flow using vessel encoded arterial spin labelling (VE-ASL). This specifically addresses the issues of computational speed of the analysis and the robustness required to deal with real patient data. The modification applies various approaches for estimation of one or more parameters that change the way a vessel, for example an artery, is encoded to provide the fast analysis.

Abstract: In a method and apparatus for acquiring magnetic resonance data, a resting state functional magnetic resonance imaging sequence is executed in alternation with a morphological data acquisition sequence. The alternating sequences are executed with no time interruptions therebetween, with at least one repetition of the alternating sequences. The resting state functional magnetic resonance imaging sequence can be a BOLD-EPI sequence, and the morphological imaging sequence can be an MPRAGE sequence.

Abstract: An imaging system (36) includes a Positron Emission Tomography (PET) scanner (38) and one or more processors (52). The Positron Emission Tomography (PET) scanner (38) which generates event data including true coincident events and scatter events, the event data includes each end point of a line of response (LOR) and an energy of each end point. The one or more processors (52) are programmed to generate (72) a plurality of activity map and attenuation map pairs based on the true coincident events, and select (76) an activity map and an attenuation map from the plurality of activity and attenuation map pairs based on the scattered events.

Abstract: Methods and systems for designing an earpiece device are provided. The method includes receiving a plurality of images for a respective plurality of individuals. Each image includes at least one ear anatomy. For each image, a three-dimensional (3D) surface representing the at least one ear anatomy is extracted, to form a plurality of extracted surfaces corresponding to the plurality of images. At least one statistical measurement representative of at least a portion of the plurality of individuals is determined from among the plurality of extracted surfaces. At least one design parameter for the earpiece device is optimized based on the at least one statistical measurement, The earpiece device is formed using the optimized at least one design parameter.

Abstract: A method for generating a robust radiotherapy treatment plan for a treatment volume of a subject. An adjusted voxel-specific dose objective is determined by “smearing” an initial voxel-specific dose objective a specified distance in at least one direction. A treatment plan based on such adjusted dose objective will be more robust with respect to setup uncertainties and organ movements. Smearing of the dose objective corresponds to adjusting the dose objective dose value of a voxel in accordance with dose objective dose values of voxels within the specified distance.

Abstract: A system and method for producing images depicting a plurality of slice locations in a subject using a magnetic resonance imaging (“MRI”} system is provided. In particular, the system and method utilize time-shifted multiband radio frequency (“RF”} pulses to lower peak voltage and peak power requirements when using conventional multiband RF pulses. A time-shifted multiband RF pulse includes at least two component RF pulses, which may be single-band or multiband pulses. The component RF pulses are designed such that they do not have temporal footprints that completely overlap; although, they may have temporal foot-prints that partially overlap or do not overlap at all. The MRI system is used to acquire magnetic resonance signals formed in response to a time-shifted multiband RF pulse and, from these acquired signals, images depicting each of the plurality of slice locations in the subject are reconstructed.

Abstract: A method of magnetic resonance (MR) imaging of a volume undergoing repetitive motion includes obtaining source slice data indicative of a plurality of source slices during the repetitive motion, and obtaining anchor slice data indicative of an anchor slice during the repetitive motion. The anchor slice intersects the plurality of source slices. The source slice data and the anchor slice data are reconstructed. A three-dimensional image assembly procedure is implemented to generate, for each phase of the repetitive motion, volume data based on a respective subset of the reconstructed source slice data. For each phase of the repetitive motion, the respective subset of slices is selected based on a correlation of the source slice data and the anchor slice data along an intersection between each source slice and the anchor slice. The source slice data of the selected subset is corrected for misalignment with the anchor slice data.