Abstract: A system for and method of determining and compensating for the effect of a field influencing object on a field sensor, preferably a coil, that is within a navigational domain. The navigational domain contains navigational magnetic energy and disturbing magnetic energy, and the field influencing object produces the disturbing magnetic energy in response to the navigational magnetic energy. The correction system includes a first transmitter for projecting into the navigational domain field energy in a first waveform sufficient to induce a first signal value in the sensing coil. The system also includes a second transmitter for projecting into the navigational domain field energy in a second waveform sufficient to induce a second signal value in the sensing coil. The system further includes a signal processor for receiving the first signal value and for receiving the second signal value to determine the effect of the electrically conductive object on the field sensor.

Abstract: The disclosure is directed to techniques in which magnetic resonance imaging (MRI) is coordinated with the operation of an implantable medical device (IMD). By using an IMD to sense conditions, MRI can be improved because the sensed conditions can accurately define timing for application of electromagnetic radiation bursts. Moreover, by applying stimulation pulses specifically to coordinate the electromagnetic radiation bursts, the MRI may also be improved.

Abstract: A catheter comprises an elongate body extending along a first longitudinal axis and having an outermost radial surface; a coil wound in a substantially cylindrical shape and extending along a second longitudinal axis that is coincident with the first longitudinal axis. At least a portion of the coil is proximate to the outermost radial surface of the elongate body.

Abstract: In a method to determine a kidney function parameter of kidneys of an examination person with the aid of magnetic resonance tomography, at least one magnetic resonance measurement is implemented for an examination region of the examination person that comprises a urinary bladder of the examination person, to acquire magnetic resonance data from the examination region that include at least image data. The concentration of a urophanic substance in the urinary bladder of the examination person is automatically determined based on the acquired magnetic resonance data. A volume of the urinary bladder is automatically determined based on the acquired image data. A kidney function parameter of the kidneys of the examination person is automatically determined on the basis of the determined concentration of the urophanic substance in the urinary bladder and of the specific volume of the urinary bladder.

Abstract: A deflectable tip catheter that is safe and effective for use in a magnetic resonance imaging environment. The deflectable tip catheter is configured such that it includes a built-in antenna, such as a loopless antenna or a loop antenna. The built-in antenna permits the deflectable tip catheter to be actively tracked and/or visualized. Depending upon the specific configuration of the deflectable tip catheter, the catheter may be tracked and/or visualized as a single unit, it may be tracked and/or visualized separate and independent of other components or instruments associated with the catheter, such as pull wires, injection needles, surgical instruments, and the like. The catheters described herein include injection type catheters and/or guidance type catheters.

Abstract: A system (100) including a catheter mounted magneto sensor (114), such as a superconducting quantum interference device (SQUID), and methods using the system are disclosed, where the system and method are designed to detect changes in a magnetic field in a body of interest, such as a patient, to detect changes in a magnetic field in a patient, to identify loci in a target body that accumulate magnetic particles or to identify vulnerable plague in a patient.

Abstract: A system to navigate an imaged subject in relation to an acquired image of the imaged subject is provided. The system includes an intracardiac echocardiography (ICE) imaging system having a transducer operable to acquire image data so as to create a four-dimensional image model of the imaged subject. The model is defined in spatial relation and orientation relative to an image coordinate system. A tracking system is operable to track movement and orientation of the transducer through the imaged subject relative to a tracking coordinate system. A controller is electrically connected in communication with the imaging system and the tracking system. The controller is operable to register the image coordinate system with the tracking coordinate system, and to calibrate the image coordinate system and the tracking coordinate system relative to a common reference having fiducials of known spatial relation.

Abstract: A stylet for an image guided system, which includes a locating device and which is operable for emitting an electromagnetic field for locating the stylet. The stylet includes a flexible elongate member, an electrically conductive member, and a reinforcement member. The reinforcement member is disposed inside the electrically conductive member and is made out of a magnetic material. The reinforcement member reinforces the stylet and provides electrical communication between the conductive member and the locating device such that current induced in the conductive member is transmitted to the locating device via the reinforcement member.

Abstract: A microcoil is manufactured by rolling a trace unit in such a way as to form at least one winding. The trace unit is comprised of a conductive trace attached to a flexible insulating film. A preferred embodiment of the microcoil contains both a first winding and a second winding electrically connected and spaced apart by ajoining portion. The microcoil may be used for internal magnetic resonance imaging of patient by attaching the microcoil to a catheter.

Abstract: An electrode for use on a medical device is disclosed. The electrode may have a main body of electrically conductive material extending along an axis and having a proximal end and a distal end. The body may be configured to emit electrical energy in accordance with a predefined diagnostic or therapeutic function. The body may have a groove disposed over an outermost surface of the body. The electrode may also include a magnetic resonance imaging (MRI) tracking coil disposed in said groove. The MRI tracking coil may comprise electrically insulated wire, for example. A catheter including an electrode, as well as a method for determining the location of an electrode, are also disclosed.

Abstract: An apparatus for percutaneously implanting a localization wire into a tissue mass comprises a cannula with a preloaded localization wire. An actuator is provided to effect the relative movement of the cannula and localization wire such that a distal end of the localization wire is exposed to the tissue mass. A method for implanting a localization wire includes inserting a cannula with a preloaded localization wire into a tissue mass and relatively moving the cannula and localization wire to expose a portion of the localization wire to the tissue mass.

Abstract: The present invention relates to an elongate intravascular device adapted to be advanced through a vessel of a subject. The present invention further includes an antenna which is disposed on an inflatable member such that the antenna can be increased or decreased in size to more accurately tune the system in which it is employed.

Abstract: In vivio deep brain medical probe systems include: (a) an NMRI compatible cannula comprising a plurality of concentric axially extending tubes with a receiving bore; and (b) an elongate antenna member with a conductor and an insulating layer configured to slidably advance through cannula bore to define an MRI receive antenna.

Abstract: A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures includes an invasive combined electrophysiology and imaging antenna catheter which includes an RF antenna for receiving magnetic resonance signals and diagnostic electrodes for receiving electrical potentials. The combined electrophysiology and imaging antenna catheter is used in combination with a magnetic resonance imaging scanner to guide and provide visualization during electrophysiologic diagnostic or therapeutic procedures, such as ablation of cardiac arrhythmias. The combined electrophysiology and imaging antenna catheter may further include an ablation tip, and be used as an intracardiac device to deliver energy to selected areas of tissue and visualize the resulting ablation lesions. The antenna utilized in the combined electrophysiology and imaging catheter for receiving MR signals is preferably of the coaxial or “loopless” type.

Abstract: An improved endoscopic device which is introduced into the intestinal tract of a living organism and which operates autonomously therein, adapted to obtain and store or transmit one or more types of data such as visual image data, laser autofluorescence data, or ultrasonic waveform data. In another aspect of the invention, an improved endoscopic device useful for implanting the aforementioned endoscopic smart probe is disclosed. In another aspect of the invention, apparatus for delivering agents including nanostructures, radionuclides, medication, and ligands is disclosed. In another aspect of the invention, apparatus for obtaining a biopsy of intestinal tissue is disclosed. In another aspect of the invention, apparatus for detecting the presence of one or more molecular species within the intestine is disclosed. Methods for inspecting and/or treating the interior regions of the intestinal tract using the aforementioned apparatus are also disclosed.

Abstract: Systems and methods for sensing external magnetic fields in implantable medical devices are provided. One aspect of this disclosure relates to an apparatus for sensing magnetic fields. An apparatus embodiment includes a sensing circuit with at least one inductor having a magnetic core that saturates in the presence of a magnetic field having a prescribed flux density. The apparatus embodiment also includes an impedance measuring circuit connected to the sensing circuit. The impedance measuring circuit is adapted to measure impedance of the sensing circuit and to provide a signal when the impedance changes by a prescribed amount. According to an embodiment, the sensing circuit includes a resistor-inductor-capacitor (RLC) circuit. The impedance measuring circuit includes a transthoracic impedance measurement module (TIMM), according to an embodiment. Other aspects and embodiments are provided herein.

Abstract: Systems and methods for a resonator with an adjustable capacitance for a medical device. In one embodiment, a resonator system includes a resonator device with an LC resonator circuit that has an adjustable capacitance, an inductor coil in series with the adjustable capacitance, and an adjustable capacitance control that can control the adjustable capacitance to obtain different particular capacitance values. This embodiment also includes a medical device, positioned with the resonator device, so that at least a portion of the inductor coil surrounds a space that is surrounded by at least a portion of the medical device.

Abstract: Extended-coverage magnetic resonance imaging coils with optimized homogeneity in longitudinal sensitivity are described. One exemplary coil includes four elements, where two of the elements are opposed-solenoid imaging elements and two of the elements are single loop imaging elements.

Abstract: One or more light beam endowed with photonic orbital angular momentum generating devices (18) are mounted at preselected locations on an insertable instrument (14) to hyperpolarize nuclear magnetic dipoles in a region of interest (80). The hyperpolarized nuclear magnetic dipoles are caused to resonate, generating magnetic resonance signals. A controller (42) controls gradient coils to induce a magnetic field gradient across the region of interest, such that the frequency of the resonance signals is indicative of spatial position. A frequency-to-position decoder (50) converts the resonance signal frequencies into spatial positions. A video processor (52) combines the spatial positions and a portion of a diagnostic image from a diagnostic image memory (56) into a combined display which depicts the location of the region of interest or a portion of the instrument marked on the diagnostic image and displays the combined image on a monitor (54).

Abstract: An adaptation probe for insertion into implanted electrode devices of active medical implants to enable them for use in high-frequency magnetic alternating fields of MRI systems comprises an elongated, flexible probe body, and at least one electrical assembly, which has one or more electrical components connected to an interface, in the probe body, and which can be electrically connected to a supply lead of the electrode device such that the electrically properties of the electrode device can be adapted, in particular the frequency-dependent resistance, impedance, capacitance, or inductance thereof.

Abstract: Systems and methods are provided for graphically configuring leads for a medical device. According to one aspect, the system generally comprises a medical device and a processing device, such as a programmer or computer, adapted to be in communication with the medical device. The medical device has at least one lead with at least one electrode in a configuration that can be changed using the processing device. The processing device provides a graphical display of the configuration, including a representative image of a proposed electrical signal to be applied by the medical device between the at least one electrode of the medical device and at least one other electrode before the medical device applies the electrical signal between the at least one electrode and the at least one other electrode. In one embodiment, the graphical display graphically represents the lead(s), the electrode(s), a pulse polarity, and a vector.

Abstract: A system for controlling a medical device in a patient. A display system displays an image of a volume of the patient in a virtual three-dimensional space. A stylus is controllable to actuate a virtual element in the virtual space. A navigation system controls the medical device in the patient volume based on a position of the actuated virtual element. This inherently three-dimensional interface allows a physician to actuate the medical device more intuitively than possible using a two-dimensional interface.

Abstract: A catheter for magnetic navigation in the human body, has a magnet arranged in the catheter tip in order to move a catheter to the desired position in the body by interaction with an external magnetic field, and has a number of separated electromagnets, that can be controlled independently of one another, distributed along the length of the catheter body.

Abstract: Methods and systems for obtaining intravascular magnetic resonance images of blood flow are disclosed. In preferred forms, a train of radio frequency (RF) pulses is produced by an intravascularly introduced RF transmitter positioned in proximate location to the blood flow so as to create a continuous stream of coherently excited protons of the blood flow. The coherently excited protons of the blood flow are sampled as the protons freely precess while flowing through a region of three dimensional space unaffected by the ongoing intravascular RF excitation. An image of the sampled coherently excited protons may then be constructed.

Abstract: An MR system features an intracavity probe and associated interface device. The probe includes a shaft, a balloon at one end thereof, and a coil loop within the balloon. The loop has two drive capacitors and a tuning capacitor, all of which in series. A junction node between the drive capacitors serves as a ground for electrically balancing the loop. Diametrically opposite the node, the tuning capacitor enables the loop to resonate at the operating frequency of the MR system. The interface allows the MR system to couple the loop to a port of the MR system during a receive cycle thereof and decouple it from the port during a transmit cycle thereof. With its balloon inserted and inflated within a cavity of a patient, the probe allows the MR system to generate images and/or spectra of the region of interest using the MR signals received by the loop.

Abstract: Systems, methods and apparatus are provided through which a compact pod insertable into the rectum for Magnetic Resonance Imaging/Magnetic Resonance Spectroscopy (MRI/MRS) examination of the prostate and containing two receive coils, each connected to transmit blocking and pre-tuned trap circuitry which can be superimposed within the pod in close proximity, can, without either circuit interfering with the other, efficiently gather, for imaging and tissue analysis, radio frequency signals emanating from magnetically disturbed nuclei in prostate tissue.

Abstract: Methods for determining the size, pathology, and volume of embolic debris captured in an embolic protection filtering device. The methods may include providing an embolic protection filtering device and scanning the filtering device with a computed tomography scanner. The methods may also include analyzing digital images produced during the scanning step.

Abstract: A magnetic resonance imaging system for interventional MR imaging involves operations to insert a device such as a catheter into an object. According to the system, a tip position of the catheter is detected, data indicative of moved loci of the catheter are produced from data indicative of the detected tip position, and the produced movement locus data are displayed. In addition, even when an operator changes the progress direction of the device such as a puncture needle, an imaging cross-section automatically tracks movements of the device. Appropriate preoperative planning is also provided.

Abstract: An apparatus including a device such as a catheter or guidewire having dimensions suitable for percutaneous delivery to a patient; and a magnetic resonance (MR) compatible antenna associated with the device in a manner that provides a prescribed radial and/or longitudinal orientation of the antenna at a point of interest within a blood vessel of a patient. An antenna suitable for radial and/or longitudinal orientation. A method including inserting a medical device having an antenna capable of transmitting radio frequency signals in a blood vessel of a patient and radially and/or longitudinally orienting the antenna at a point of interest within a blood vessel of a patient.

Abstract: The invention relates to a method for post-processing a 3D image data set of a vessel structure of a human or animal body, in which a 2D DSA (Digital Subtraction Angiography) of the vessel structure is recorded and registered with the 3D image data set. The 2D DSA is compared with a corresponding projection image computed from the 3D data set and this is changed, e.g. by changing the segmentation parameters, to adapt it to the 2D DSA. This enables the outstanding local resolution of the 2D DSA to be used for improving the 3D image data set.

Abstract: A system for automatically adapting image acquisition parameters based on imaging and/or device tracking feedback is provided. An example system includes a subsystem for acquiring images (e.g., MR) of an object and tracking data for a device (e.g. catheter) inserted into the object and controllably moveable within the object. The system also includes an image processor for processing the images and a device tracking logic for computing device parameters (e.g., speed, direction of travel, rate of speed change, position, position relative to a landmark, device orientation). Based on the images and device parameter computations, a parameter control and adjustment logic can automatically update one or more image acquisition parameters that control the image acquisition subsystem.

Abstract: We present, in exemplary embodiments of the present invention, a system combining anatomical imaging technologies (e.g., MR) with optical technologies. The system can be used for a variety of applications, including, but not limited to, (1) cancer diagnosis and staging; (2) image guidance; and (3) radiation therapy planning. Image guidance may include guiding a biopsy. For example, a prostatectomy potentially has severe side effects, such as impotence and incontinence. Thus, a histologically-confirmed diagnosis, such as one provided from a biopsy, may prevent unnecessary prostatectomy. Image guidance may also include guiding minimal invasive therapy, such as brachytherapy focused ultrasound. The present invention may be used to plan radiation therapy, for example, by detecting, and thus sparing, healthy tissue from radiation exposure.

Abstract: An intracavity probe for use with an MR system allows images or spectra of a region of interest within a cavity of a patient to be obtained. The probe includes a shaft, a balloon at one end thereof, and a coil loop within the balloon. The coil loop preferably includes two drive capacitors and a tuning capacitor, all of which in series. A junction node between the drive capacitors serves as a ground for electrically balancing the coil loop. Diametrically opposite the junction node, the tuning capacitor enables the coil loop to resonate at the operating frequency of the MR system. Across each drive capacitor is connected an output cable having an electrical length of SL+n(?/4). The output cables terminate in a plug that is used to connect the coil loop to an interface device for the intracavity probe.

Abstract: A blood flow calibration system 500 including a computer 400 operable to determine and store calibration data for a flow meter 124, a test system 530operable to simulate blood flow for the flow meter 124, thereby allowing the computer 400 to determine the calibration data, and a programmer 300 operable to transfer the calibration data from the computer 400 to the flow meter 124. The flow meter 124 preferably includes a power management circuit 348a,b operable to detect whether the flow meter 124 is powered. In the event that the flow meter 124 is unpowered, the power management circuit 348a,b is preferably able to supply power to a portion of the flow meter 124 in order to transfer the calibration data thereto.

Abstract: Herein is disclosed a magnetic resonance imaging probe, having a probe shaft including a magnetic resonance antenna, and a spring tip attached to a distal end of the antenna.

Abstract: Herein is disclosed a probe, including a first electrode disposed at least partially on the probe surface, a second electrode disposed at least partially on the probe surface, a first conductor electrically coupled to the first electrode, a second conductor electrically coupled to the second electrode, and a reactive element electrically coupling the first conductor and the second conductor.

Abstract: An array for use with a surgical navigation system is provided. The array comprises a frame and first, second and third markers attached to the frame. The first, second and third markers are detectable by a tracking system used in image guided surgery, and the first marker is movable relative to the frame. In one embodiment, at least one marker slides along the frame from a first position where it is held in place to a second position where it is also held in place. In another embodiment, one or more of the markers is removed from the frame at a first position and reattached to the frame at a second position. In still another embodiment, a portion of the frame itself moves with the movable marker.

Abstract: An apparatus, system and method of a resonator device with an adjustable capacitor for allowing the resonance frequency (F) of the resonator device to continue to be matched to the Larmor frequency of the MRI system. The resonator device includes an inductor coil, a conductive member, a sleeve having first and second sockets that receive at least portions of the inductor coil and the conductive member as electrodes to provide a capacitor structure. Dielectric material can be positioned between at least the first and second sockets, where changes in the cross sectional area defined by the induction coil cause changes in the capacitance value (C) as one or more of the electrodes move within the socket. Changes in the inductance and the capacitance values allow for the resonance frequency (F) of the resonator device to continue to be matched to the Larmor frequency of the MRI system.

Abstract: A localization mechanism, or fixture, is used in conjunction with a breast coil for breast compression and for guiding a core biopsy instrument during prone stereotactic biopsy procedures in both open and closed Magnetic Resonance Imaging (MRI) machines. The localization fixture includes a fiducial marker and three-dimensional Cartesian positionable guide for supporting and orienting an MRI-compatible biopsy instrument with detachable probe/thumb wheel probe to the biopsy site of suspicious tissues or lesions.

Abstract: A method for segmenting a body structure image data set produced from a medical imaging method includes: using a reference data set to define delineated body structures in the body structure image data set; and ascertaining an overall mapping function that substantially maps a reference data set onto the body structure image data set, wherein the overall mapping function comprises a portion that includes a dissection of the body structure image data set into structural parts and their individual rearrangement, and a portion which includes a global deformation and/or shift of the body structures.

Abstract: Embodiments of the invention pertain to a method and apparatus for magnetic resonance imaging and spectroscopy (MRI/S). In a specific embodiment, the method and apparatus for MRI/S can be applied at two or more resonant frequencies utilizing a wireless RF receiving coil. In an embodiment, the wireless coil, which can be referred to as the implant coil, can be incorporated into an implantable structure. The implantable structure can then be implanted in a living body. The wireless RF receiving coil can be inductively coupled to another RF coil, which can be referred to as an external coil, for receiving the signal from the wireless implant RF coil. In an embodiment, the implantable structure can be a capsule compatible with implantation in a living body. The implantable structure can incorporate a mechanism for adjusting the impedance of the implant coil so as to alter the resonance frequency of the implant coil.

Abstract: A system for and method of determining and compensating for the effect of a field influencing object on a field sensor, preferably a coil, that is within a navigational domain. The system includes a first and second transmitter to create signals. A signal processor is able to process the created signals. The method can include determining interference and/or a correct signal based on the two signals. Also, a shield can be provided to limit transmission of selected fields.

Abstract: Systems and methods are provided for graphically configuring leads for a medical device. According to one aspect, the system generally comprises a medical device and a processing device, such as a programmer or computer, adapted to be in communication with the medical device. The medical device has at least one lead with at least one electrode in a configuration that can be changed using the processing device. The processing device provides a graphical display of the configuration, including a representative image of a proposed electrical signal to be applied by the medical device between the at least one electrode of the medical device and at least one other electrode before the medical device applies the electrical signal between the at least one electrode and the at least one other electrode. In one embodiment, the graphical display graphically represents the lead(s), the electrode(s), a pulse polarity, and a vector.

Abstract: The present technique provides a novel method and apparatus for magnetic resonance device tracking. In one aspect of the present technique, a plurality of magnetic resonance tracking signals are acquired in response to a corresponding plurality of pulse sequences, wherein the plurality of magnetic resonance tracking signals are acquired from a tracking coil mounted in a device. A location value is also determined for each pulse sequence to produce a plurality of location values. Further, a candidate location value of the plurality of location values for replacement, an off-resonance error value for the plurality of magnetic resonance tracking signals, and a replacement location value based on the off-resonance error value are determined. The location of the device is also determined based on the plurality of location values, wherein the candidate location value was replaced in the plurality of location values with the replacement location value.

Abstract: A microcoil is manufactured by rolling a trace unit in such a way as to form at least one winding. The trace unit is comprised of a conductive trace attached to a flexible insulating film. A preferred embodiment of the microcoil contains both a first winding and a second winding electrically connected and spaced apart by a joining portion. The microcoil may be used for internal magnetic resonance imaging of patient by attaching the microcoil to a catheter.

Abstract: An outer balloon is provided in the interior thereof with a coil conductor for a local endo coil for intracorporeal placement for recording magnetic resonance signals, which can be deployed for the purpose of receiving signals. In addition to the coil, a filling medium is fed into the balloon, so that the deployed coil conductor is surrounded at least in sections by at least one material having a dielectric constant ?r>1.

Abstract: A method provides guidance to the physician during a live bronchoscopy or other endoscopic procedures. The 3D motion of the bronchoscope is estimated using a fast coarse tracking step followed by a fine registration step. The tracking is based on finding a set of corresponding feature points across a plurality of consecutive bronchoscopic video frames, then estimating for the new pose of the bronchoscope. In the preferred embodiment the pose estimation is based on linearization of the rotation matrix. By giving a set of corresponding points across the current bronchoscopic video image, and the CT-based virtual image as an input, the same method can also be used for manual registration. The fine registration step is preferably a gradient-based Gauss-Newton method that maximizes the correlation between the bronchoscopic video image and the CT-based virtual image. The continuous guidance is provided by estimating the 3D motion of the bronchoscope in a loop.

Abstract: A system and method for treating a target tissue region (e.g., malignant tissue) is provided. A hyperthermic probe is placed into contact with the target tissue region, and the target tissue region is exposed to a therapeutic x-ray radiation beam. The probe is operated to increase the temperature of the target tissue region, thereby facilitating a therapeutic effect of the radiation beam. Image data of the probe containing a fiducial datum is acquired while in contact with the target tissue region, a position of the target tissue region within a treatment coordinate system is determined based on the fiducial datum, and the radiation beam is spatially adjusted relative to the target tissue region based on the determined position of the target tissue region.

Abstract: Disclosed is a guide catheter that includes one or more RF antennas to enhance the visibility of the guide catheter in MR imagery. One embodiment of the guide catheter includes a loop coil at the distal end of the guide catheter and a loopless antenna between the distal end and the proximal end. By combining a loop coil and a loopless antenna on the catheter, the shaft of the catheter may be visible in MR imagery while the distal end may appear in the MR imagery more brightly than the shaft.

Abstract: A magnetic resonance probe may include a plurality of center conductors, at least some center conductors including a conductive core and an insulator disposed at least partially about the core along at least a portion of the core, a first dielectric layer disposed at least partially about the plurality of center conductors in a proximal portion of the probe, an outer conductive layer at least partially disposed about the first dielectric layer, and a plurality of electrodes, at least one electrode being coupled to one of the center conductors and disposed at least partly on a probe surface.