Abstract: Provided herein are compounds useful for imaging granzyme B. An exemplary compound provided herein is useful as a radiotracer for position emission tomography (PET) and/or single photon emission tomography (SPECT) imaging. Methods of imaging granzyme B, combination therapies, and kits comprising the granzyme B imaging agents are also provided.

Abstract: An analysis apparatus includes processing circuitry configured to obtain quantitative values of a plurality of types of tissue properties relating to a region of interest of a subject, and generate a diagram of the region of interest based on the quantitative values.

Abstract: A fluid delivery apparatus includes controller hardware, a diaphragm pump, a positive displacement pump, and a fluid conduit extending between the diaphragm pump and the positive displacement pump. During operation, and delivering fluid to a downstream recipient, the controller hardware draws fluid into a chamber of the diaphragm pump from a fluid source container. The controller hardware applies pressure to the chamber of the diaphragm pump to output the fluid in the chamber of the diaphragm pump downstream through the fluid conduit to the positive displacement pump. During application of the pressure to the chamber and outputting the fluid in the chamber of the diaphragm pump downstream, the controller hardware activates the positive displacement pump to pump the fluid from the positive displacement pump to the downstream recipient.

Abstract: An implantable tissue marker device is provided to be placed in a soft tissue site through a surgical incision. The device can include a bioabsorbable body in the form of a spiral and defining a spheroid shape for the device, the spiral having a longitudinal axis, and turns of the spiral being spaced apart from each other in a direction along the longitudinal axis. A plurality of markers can be disposed on the body, the markers being visualizable by a radiographic imaging device. The turns of the spiral are sufficiently spaced apart to form gaps that allow soft tissue to infiltrate between the turns and to allow flexibility in the device along the longitudinal axis in the manner of a spring.

Abstract: Methods and systems are provided for adaptive scan control. In one embodiment, a method includes processing acquired projection data of a monitoring area of a subject to measure a first contrast signal of a contrast agent administered to the subject via a first injection, initializing a contrast scan of the subject according to a fallback scan prescription, determining when each of a plurality of zones of the contrast scan are estimated to occur based on the contrast signal, generating a personalized scan prescription for the contrast scan based on when each of the plurality of zones are estimated to occur, and performing the contrast scan according to the personalized scan prescription after a second injection of the contrast agent.

Abstract: Described herein is a computer implemented method of measuring the determining the Left Ventricular Ejection Fraction (LVEF) of a patient. The S Wave, P Wave, R Wave and T Wave are continually measured using an ECG apparatus. The LVEF is computed as a function of S Wave, P Wave, R Wave and T Wave. The system described herein includes an ECG apparatus and an analytical computing device for computing the LVEF.

Abstract: A method, system and computer readable medium of: providing feature data of at least one organ at risk or target volume of said patient from a database of non-transitory data stored on a data storage device of prior patients data; generating, using a data processor, a distribution of dose points of the at least one organ at risk or target volume of said patient based on said feature data; calculating, using the data processor, at least one of (i) a probability of toxicity for the at least one organ at risk or (ii) a probability of treatment failure for the at least one target volume, based on said distribution of dose points; assessing, using the data processor, a dosimetric-outcome relationship based on the calculated probability; and automatically formulating, using the data processor, a treatment plan using the dosimetric-outcome relationship to minimize the at least one treatment-related risk.

Abstract: The present invention is directed to a method of identifying, isolating, and enabling downstream analysis of circulating tumor cells comprising contacting a blood or blood serum sample of a subject with a composition comprising a phospholipid ether analog bound to a luminescent molecule or a magnetic bead and subjecting the blood or blood serum sample of the subject to fluorescent microscopy, flow cytometry or magnetic isolation.

Abstract: A diagnostic system is provided for classifying a soft tissue condition within a region of interest of a subject. The diagnostic system comprises a spectrometer system configured to irradiate a soft tissue within a region of interest of a subject, and configured to generate spectral data by acquiring at least a portion of the reflected or emitted light from the region of interest. The diagnostic system further comprises a thermal detection system including at least one thermal sensor that is configured to acquire thermal detection data from the region of interest. A computer system is then used to build a classification model based on input thermal detection and spectral data. The classification model is then applied to an unknown soft tissue condition to classify the condition (e.g., classifying cellulitis from pseudocellulitis).

Abstract: A skin condition measuring module according to the present invention can be designed to effectively diagnose a user's skin condition while being installed within or connected with: a kiosk; a skin condition measuring mirror; a vending machine for performing skin condition measurement and providing cosmetic products; or a module-embedded skin condition measuring device.

Abstract: A biopsy marker having a spring-loaded anchor. The biopsy marker includes an insertion orientation and an anchored orientation. The lateral span/cross-sectional area of the marker is configured to change when transitioning between the insertion orientation and the anchored orientation. In an embodiment, the spring-loaded anchor is configured to spring about a predefined rotational axis. An embodiment of the biopsy marker may be comprised of a single wire construction.

Abstract: A system (e.g., an ultrasound imaging system) is provided. The system includes an ultrasound probe configured to acquire three-dimensional (3D) ultrasound data of a volumetric region of interest (ROI). The system further includes a display, a memory configured to store programmed instructions, and a controller circuit. The controller circuit includes one or more processors. The controller circuit is configured to execute the programmed instructions stored in the memory. When executing the programmed instructions, the controller circuit performs a plurality of operations. The operations includes collecting the 3D ultrasound data from an ultrasound probe and identifying a select set of the 3D ultrasound data corresponding to an object of interest within the volumetric ROI. The operations further include segmenting the object of interest from the select set of the 3D ultrasound data, generating a visualization plane of the object of interest, and displaying the visualization plane on the display.

Abstract: A method of manufacturing a suspension of gas-filled microvesicles by reconstituting a freeze-dried product and a suspension obtained according to said method, where the freeze-dried product has been subjected to a thermal treatment.

Abstract: An image fusion method includes acquiring a trigger signal for flat-field correction, controlling a first image acquisition device to start a flat-field correction function to perform a flat-field correction process on the first image acquisition device according to the trigger signal for the flat-field correction, and obtaining a fused image in the flat-field correction process according to an infrared image acquired by the first image acquisition device and a visible light image acquired by a second image acquisition device. The first image acquisition device does not output infrared images during the flat-field correction process.

Abstract: A medical image diagnosis apparatus according to an embodiment includes obtaining circuitry, detecting circuitry, deriving circuitry, and controlling circuitry. The obtaining circuitry is configured to obtain image data of a patient. The detecting circuitry is configured to detect each of a plurality of sites of the patient from the image data. The deriving circuitry is configured to derive information about a structuring member in the patient, on the basis of a detection result obtained by the detecting circuitry. The controlling circuitry is configured to determine an injection condition for a contrast agent to be administered to the patient for a contrast-enhanced scan, on the basis of the information about the structuring member.

Abstract: An implant can include a flexible body made of a non-bioresorbable hydrogel material. The implant can also include a radiopaque marker located within the flexible body, where the body and the radiopaque marker can be implanted in a body cavity to mark the cavity in a radiographic image of the cavity.

Abstract: The present invention relates to a method of producing an optically detectable and retro-reflective medical tracking marker, wherein electromagnetic energy is applied to at least one section of a retro-reflective surface of a marker structure in an amount that is sufficient to alter the material properties of the retro-reflective surface, such that the capability of reflecting electromagnetic radiation of the at least one section is reduced to a second capability of reflecting electromagnetic radiation. The present invention further relates to a corresponding retro-reflective medical tracking marker and a corresponding use thereof.

Abstract: Methods and systems are provided for adaptive scan control. In one embodiment, a method for a computing device communicatively coupled to an imaging system includes, selecting a scan protocol, displaying an adaptive scan protocol graphical user interface (GUI) on a display device coupled to the computing device, adjusting one or more parameters of the scan protocol in response to user input to the adaptive scan protocol GUI, updating a visual representation of the scan protocol displayed via the adaptive scan protocol GUI in correspondence to the adjustment of the one or more parameters of the scan protocol, and storing the adjusted scan protocol in memory of the computing device.

Abstract: Provided herein are methods, systems, and related vectors and compositions allowing for noninvasive control of neural circuits. In particular, the methods and systems herein described utilize acoustically targeted chemogenetics to achieve a noninvasive neuromodulation in specifically selected cell-types among spatially selected brain regions.

Abstract: According to one embodiment, a medical image processing apparatus includes an acquiring unit, an identifying unit, and a display controller. The acquiring unit acquires volume data indicating the state of a three-dimensional region including a mass portion and a plurality of blood vessels derived from the mass portion in a subject. The identifying unit specifies a region corresponding to the mass portion and the blood vessels in the volume data as a region of interest. The identifying unit identifies the mass portion and each of the blood vessels in the region of interest. The display controller assigns a different display mode to at least one of the mass portion and the blood vessels.

Abstract: An exemplary surgical system is configured to 1) access a plurality of surgical site scenes captured entirely outside a structure within a patient, each surgical site scene in the plurality of surgical site scenes being captured from reflected light of a different waveband of a plurality of wavebands, each waveband of the plurality of wavebands being reflected by structure tissue of the structure and non-structure tissue outside the structure; 2) detect a difference between spectral reflectances of each of the surgical site scenes in the captured surgical site scenes, and 3) identify, based on the detected difference between the spectral reflectances of each of the surgical site scenes in the captured surgical site scenes, pixels in the captured surgical site scenes that correspond to the structure tissue and pixels in the captured surgical site scenes that correspond to the non-structure tissue outside the structure.

Abstract: When imaging an imaging subject, a pixel value is maintained in a state of small fluctuation of the pixel value over an entire expected duration. A generation device includes: an imaging information acquiring unit acquiring information of an imaging site of an imaging subject; a subject information acquiring unit acquiring information of the imaging subject; and a protocol generation unit generating an injection protocol for a contrast medium based on the information of the imaging site and the information of the imaging subject, wherein the protocol generation unit generates the injection protocol including a first phase in which an injection rate decreases with a first acceleration, and a second phase which follows the first phase and in which the injection rate decreases with a second acceleration, and the injection rate at a start of the second phase is higher than the injection rate at an end of the first phase.

Abstract: Described herein are methods, software, systems and devices for detecting the presence of an abnormality in an organ, tissue, body, or portion thereof of a subject by analysis of the electromagnetic fields generated by the organ, tissue, body, or portion thereof.

Abstract: The present invention is directed to methods for treating neurodegenerative diseases and/or improving cognitive function, in particular those associated with protein oligomers, aggregates or deposits, using acoustic energy, such as ultrasound. An 5 example of such a neurodegenerative disease is Alzheimer's disease. The present invention provides a method of improving cognitive function and/or memory in an individual with impaired memory and/or executive function, the method including the steps of identifying a region of the brain of the individual to be treated with acoustic energy, applying a clinically safe level of acoustic energy to the region, thereby 10 saturating or substantially saturating the region with acoustic energy, thereby improving memory in the individual.

Abstract: A device (1) for producing a solution of at least one liquid first medium and at least one second medium has a first container (2) for the first medium and a second container (3) for the second medium. Each container (2, 3) is connected to a supply line of a static mixer (9) via a pump (4, 5) that can be regulated by a controller (6). A sensor (10) is connected to the controller (6) downstream of the static mixer (9) in the flow direction. A branching valve (17) is downstream of the static mixer (9) in the flow direction and is controlled by the controller (6). A sterile filter (11) is downstream of the static mixer (9) and has an RFID tag (15) that stores process-relevant data to at least be read by the controller (6). A method also is provided for producing a solution using the device.

Abstract: Methods and systems are provided for adaptive scan control. In one embodiment, a method includes, upon an injection of a contrast agent, processing acquired projection data of an anatomical region of interest (ROI) of a subject to measure a contrast signal of the contrast agent, determining when each of a plurality of zones of a contrast scan are estimated to occur based on the contrast signal, updating a scan prescription for the contrast scan based on when each of the plurality of zones of the scan protocol are estimated to occur, and performing the contrast scan according to the updated scan prescription.

Abstract: A medical image processing device includes circuitry configured to: analyze a blood flow flowing in an observation object based on a medical observation image obtained by capturing an image of the observation object; and generate a difference result between a simulation result of a blood flow flowing in a 3D model acquired in advance for the observation object and an analysis result of a blood flow flowing in the observation object.

Abstract: A delivery system for the delivery of embolic agents to a patient includes a control valve assembly interconnecting first, second, third and fourth conduits, wherein the control valve assembly selectively moves between first, second, and third states under the control of a medical professional. In the first state, the first conduit communicates with the second conduit for transmitting a solution of embolic agents between a first syringe secured to the first conduit and a second syringe secured to the second conduit. In the second state, the second conduit communicates with the third conduit for transmitting the solution of embolic agents from the second syringe to a delivery catheter secured to the third conduit. In the third state, the third conduit communicates with the fourth conduit for flushing the delivery catheter via a third syringe, which is filled with saline, connected to the fourth conduit.

Abstract: Methods and systems are provided for adaptive scan control. In one embodiment, a method includes, upon a first injection of a contrast agent, processing acquired projection data of a monitoring area of a subject to measure a contrast signal of the contrast agent, determining when each of a plurality of zones of a contrast scan are estimated to occur based on the contrast signal, generating a scan prescription for the contrast scan based on when each of the plurality of zones are estimated to occur, and upon a second injection of contrast agent, performing the contrast scan according to the scan prescription.

Abstract: A system for image segmentation is provided. The system may obtain a target image including an ROI, and segment a preliminary region representative of the ROI from the target image using a first ROI segmentation model corresponding to a first image resolution. The system may segment a target region representative of the ROI from the preliminary region using a second ROI segmentation model corresponding to a second image resolution. At least one model of the first and second ROI segmentation models may at least include a first convolutional layer and a second convolutional layer downstream to the first convolutional layer. A count of input channels of the first convolutional layer may be greater than a count of output channels of the first convolutional layer, and a count of input channels of the second convolutional layer may be smaller than a count of output channels of the second convolutional layer.

Abstract: A microwave ablation device including a cable assembly configured to connect a microwave ablation device to an energy source and a feedline in electrical communication with the cable assembly. The microwave ablation device further includes a balun on an outer conductor of the feedline, and a temperature sensor on the balun sensing the temperature of the balun.

Abstract: The disclosure describes imaging and therapy techniques comprising nanodroplets. More particularly, aspects of the disclosure relate to the use of nanodroplets to modify nanobubbles or microbubbles to provide improved imaging and/or therapeutic techniques and compositions.

Abstract: One or more medical devices may be provided that may be used, for example, in bariatric surgery including a vertical sleeve gastrectomy. Occlusion devices can be integrated with a catheter or tube to occlude one or more proximal or distal landmarks of a stomach and a stapling guide may be used to occlude a lateral boundary of the stomach to define a cavity. A volume of the potential resultant sleeve may be determined by inserting fluid or gas into the catheter or tube, measuring pressure, and calculating the volume of the cavity.

Abstract: An image display apparatus includes a display which can display an image; and a hardware processor. The hardware processor obtains image data of a dynamic image or a moving image including a plurality of frames generated by a radiation imaging apparatus. The hardware processor displays on the display as a failure image at least one failure frame included in the dynamic image or the moving image based on the obtained image data or analyzed image data obtained by analyzing the image data, the failure frame including a reason why the dynamic image or the moving image cannot be provided for diagnosis.

Abstract: A medical system is provided having a system host and a control device connected to the system host. The medical system further includes a handpiece having a sleeve with a port opening configured to enable fluid to pass there through, a fluid channel connected to the port opening, and a fluid flow restrictor configured to restrict fluid flow of the fluid channel through the port opening. The control unit is configured to receive input from a user and control an amount of fluid provided by the fluid flow restrictor based on the input received from the user. In one aspect, the medical system is a phacoemulsification system, the handpiece a phacoemulsification handpiece, and the control device a footpedal.

Abstract: Certain aspects relate to apparatuses and techniques for non-invasive optical imaging that acquires a plurality of images corresponding to both different times and different frequencies. Additionally, alternatives described herein are used with a variety of tissue classification applications, including assessing the presence and severity of tissue conditions, such as burns and other wounds.

Abstract: Various embodiments of anchors are configured to be inserted into a heart wall of a patient to anchor a suture as an artificial chordae under an appropriate tension for proper valve function. Each of the disclosed anchor embodiments “toggles” from a first position for delivery of the anchor to the heart wall and a second position for insertion of the anchor into the heart wall. In some embodiments, it is the “toggle” to the second position that provides the insertion force for inserting the anchor into the heart muscle sufficient to retain the anchor from accidental withdrawal from the heart wall during normal valve operation (e.g., when a valve leaflet pulls on the suture attached to the anchor during systole). Such anchors are particularly suitable for use in intravascular, transcatheter procedures as described above given the inherent difficulties in providing sufficient force for insertion of an anchor into the heart wall with a flexible catheter.

Abstract: A system and method for monitoring cardiovascular and brain functions in combination with a physiological detection device, which uses a smart wearable device to detect physiological data such as heart rate and pulse pressure of a user, and transmits the physiological data to an arithmetic function. An electronic device in which a preset function and a calculation formula are built in, and the physiological data can be converted into corresponding determination parameters to monitor the possibility and risk of cardiovascular diseases and neurodegenerative diseases.

Abstract: Embodiments include methods and systems for maintaining glucose homeostasis. Systems can include a pump, a first reservoir including a homeostasis agent, an umbilical catheter capable of being advanced in the umbilical vein or in the falciform ligament, and a sensor. Systems can also include a biocompatible coating, a microprocessor in communication with the pump and the sensor, and a power supply. Methods can include implanting a pump and reservoir subcutaneously in a patient, advancing a catheter in the umbilical vein or in the falciform ligament, measuring a blood glucose level, pumping a homeostasis agent, and administering the homeostasis agent to the portal venous system.

Abstract: A method and apparatus for performing a contrast simulation of a CT or MRI scan is disclosed. Voxel(s) within a three-dimensional dataset are modified using an artificial intelligence algorithm to generate a virtual contrast three-dimensional dataset. The modification includes altering the numerical value(s) of voxels corresponding to body tissue(s) in accordance with said blood flow through said body tissue, such that an appearance of contrast is created. Multi-phase simulations can be performed to track contrast flow through the vascular tree. Some embodiments comprise inserting virtual contrast in conjunction with performing a deformity of the vascular structure.

Abstract: Image rotation in an endoscopic fluorescence imaging system is described. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The system includes a rotation sensor for detecting an angle of rotation of a lumen relative to a handpiece of an endoscope. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises electromagnetic radiation having a wavelength from about 770 nm to about 790 nm.

Abstract: Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.

Abstract: The present disclosure relates to systems and methods for controlling an MRI safe patient care/monitoring system. The system may include a an MRI safe infusion pump that contains a co-processor which acts as a central brain for all other patient care/monitoring devices in the MRI room. The co-processor is separated from the primary processor by a buffer in the infusion pump's memory, so that no actions by the co-processor can affect the primary processor. The co-processor controls the display software, alert software and alerts database. All other patient care/monitoring devices are connected to the MRI safe infusion pump in a daisy chain, so that they can share a single connection to outside the MRI room. Outside the MRI room the co-processor has access to the remote control & display, which contains the remote control GUI, and to the internet, through which it will access an external medical network, which contains an algorithm database.

Abstract: A system (200) includes a first imaging system (201) that utilizes first radiation to image an interior region of interest of a subject, including a first agent in the region of interest and a second imaging system (218) that utilizes second radiation to image a second agent in the region of interest, wherein an output of the second imaging system is used to trigger the first imaging system to scan the region of interest, including the first agent in the region of interest.

Abstract: Image rotation in an endoscopic fluorescence imaging system is described. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The system includes a rotation sensor for detecting an angle of rotation of a lumen relative to a handpiece of an endoscope. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises electromagnetic radiation having a wavelength from about 770 nm to about 790 nm and/or from about 795 nm to about 815 nm.

Abstract: A control apparatus of a radiation imaging apparatus configured to generate a plurality of radiation images to transmit to an external apparatus is provided. The control apparatus includes an acquisition unit configured to acquire a generation cycle of the plurality of radiation images, a partial readout time required for the radiation imaging apparatus to read out a region of interest in one radiation image of the plurality of radiation images, and a transmission time estimated to be required to transmit the one radiation image. The control apparatus also includes a determination unit configured to determine, based on the generation cycle, the partial readout time, and the transmission time, a time at which the radiation imaging apparatus starts transmission of the plurality of radiation images.

Abstract: Image rotation in an endoscopic fluorescence imaging system is described. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The system includes a rotation sensor for detecting an angle of rotation of a lumen relative to a handpiece of an endoscope. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises electromagnetic radiation having a wavelength from about 770 nm to about 790 nm and/or from about 795 nm to about 815 nm.

Abstract: A teleoperational medical system comprises an input device and a manipulator configured to couple with and move an instrument. The system also comprises a control system including one or more processors. In response to a determination that the instrument is inserted into an instrument workspace in a corresponding direction to a field of view of the workspace, the control system is configured to map movement of the input device to movement of the instrument according to a first mapping. In response to a determination that the instrument is inserted into the instrument workspace in a non-corresponding direction to the field of view, the control system is configured to map movement of the input device to movement of the instrument according to a second mapping. The second mapping includes an inversion of the first mapping for at least one direction of motion of the instrument.

Abstract: A multi-modal catheter combining at least NIRF and IVUs imaging channels used to reveal integrated biological and structural features of a lumen intravascularly imaged through flowing blood in vivo and corrected for distance-related attenuation and/or scattering parameters of in vivo blood to compensate for discovered overestimation of the degree of in-vivo-blood attenuation of NIRF signal Enhancing the sensitivity of detection of vascular injury and/or plaque deposition beyond the capability of a standalone IVUS imaging as a result of the use of such corrected catheter.

Abstract: A biopsy marker may include three shaped portions arranged sequentially along an axis, each shaped portion having a first surface and a second surface parallel to the first surface. A first narrow portion connects a first of the three shaped portions to a second of the three shaped portions. A second narrow portion connects the second of the three shaped portions to a third of the three shaped portions. The first narrow portion is twisted about the axis such that the first surface of the first shaped portion is at a first angle to the first surface of the second shaped portion. The second narrow portion is twisted about the axis such that the first surface of the second shaped portion is at a second angle to the first surface of the third shaped portion.