Abstract: A method and apparatus for performing a contrast simulation of a CT or MRI scan is disclosed. Voxel(s) within a three-dimensional dataset are modified using an artificial intelligence algorithm to generate a virtual contrast three-dimensional dataset. The modification includes altering the numerical value(s) of voxels corresponding to body tissue(s) in accordance with said blood flow through said body tissue, such that an appearance of contrast is created. Multi-phase simulations can be performed to track contrast flow through the vascular tree. Some embodiments comprise inserting virtual contrast in conjunction with performing a deformity of the vascular structure.

Abstract: Image rotation in an endoscopic fluorescence imaging system is described. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The system includes a rotation sensor for detecting an angle of rotation of a lumen relative to a handpiece of an endoscope. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises electromagnetic radiation having a wavelength from about 770 nm to about 790 nm.

Abstract: Methods for treating tumors by administering FLASH radiation and a therapeutic agent to a patient with cancer are disclosed. The methods provide the dual benefits of anti-tumor efficacy plus normal tissue protection when combining therapeutic agents with FLASH radiation to treat cancer patients. The methods described herein also allow for the classification of patients into groups for receiving optimized radiation treatment in combination with a therapeutic agent based on patient-specific biomarker signatures. Also provided are radiation treatment planning methods and systems incorporating FLASH radiation and therapeutic agents.

Abstract: A system (200) includes a first imaging system (201) that utilizes first radiation to image an interior region of interest of a subject, including a first agent in the region of interest and a second imaging system (218) that utilizes second radiation to image a second agent in the region of interest, wherein an output of the second imaging system is used to trigger the first imaging system to scan the region of interest, including the first agent in the region of interest.

Abstract: The present disclosure relates to systems and methods for controlling an MRI safe patient care/monitoring system. The system may include a an MRI safe infusion pump that contains a co-processor which acts as a central brain for all other patient care/monitoring devices in the MRI room. The co-processor is separated from the primary processor by a buffer in the infusion pump's memory, so that no actions by the co-processor can affect the primary processor. The co-processor controls the display software, alert software and alerts database. All other patient care/monitoring devices are connected to the MRI safe infusion pump in a daisy chain, so that they can share a single connection to outside the MRI room. Outside the MRI room the co-processor has access to the remote control & display, which contains the remote control GUI, and to the internet, through which it will access an external medical network, which contains an algorithm database.

Abstract: Image rotation in an endoscopic fluorescence imaging system is described. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The system includes a rotation sensor for detecting an angle of rotation of a lumen relative to a handpiece of an endoscope. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises electromagnetic radiation having a wavelength from about 770 nm to about 790 nm and/or from about 795 nm to about 815 nm.

Abstract: A control apparatus of a radiation imaging apparatus configured to generate a plurality of radiation images to transmit to an external apparatus is provided. The control apparatus includes an acquisition unit configured to acquire a generation cycle of the plurality of radiation images, a partial readout time required for the radiation imaging apparatus to read out a region of interest in one radiation image of the plurality of radiation images, and a transmission time estimated to be required to transmit the one radiation image. The control apparatus also includes a determination unit configured to determine, based on the generation cycle, the partial readout time, and the transmission time, a time at which the radiation imaging apparatus starts transmission of the plurality of radiation images.

Abstract: Image rotation in an endoscopic fluorescence imaging system is described. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The system includes a rotation sensor for detecting an angle of rotation of a lumen relative to a handpiece of an endoscope. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises electromagnetic radiation having a wavelength from about 770 nm to about 790 nm and/or from about 795 nm to about 815 nm.

Abstract: A teleoperational medical system comprises an input device and a manipulator configured to couple with and move an instrument. The system also comprises a control system including one or more processors. In response to a determination that the instrument is inserted into an instrument workspace in a corresponding direction to a field of view of the workspace, the control system is configured to map movement of the input device to movement of the instrument according to a first mapping. In response to a determination that the instrument is inserted into the instrument workspace in a non-corresponding direction to the field of view, the control system is configured to map movement of the input device to movement of the instrument according to a second mapping. The second mapping includes an inversion of the first mapping for at least one direction of motion of the instrument.

Abstract: A biopsy marker may include three shaped portions arranged sequentially along an axis, each shaped portion having a first surface and a second surface parallel to the first surface. A first narrow portion connects a first of the three shaped portions to a second of the three shaped portions. A second narrow portion connects the second of the three shaped portions to a third of the three shaped portions. The first narrow portion is twisted about the axis such that the first surface of the first shaped portion is at a first angle to the first surface of the second shaped portion. The second narrow portion is twisted about the axis such that the first surface of the second shaped portion is at a second angle to the first surface of the third shaped portion.

Abstract: A multi-modal catheter combining at least NIRF and IVUs imaging channels used to reveal integrated biological and structural features of a lumen intravascularly imaged through flowing blood in vivo and corrected for distance-related attenuation and/or scattering parameters of in vivo blood to compensate for discovered overestimation of the degree of in-vivo-blood attenuation of NIRF signal Enhancing the sensitivity of detection of vascular injury and/or plaque deposition beyond the capability of a standalone IVUS imaging as a result of the use of such corrected catheter.

Abstract: A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

Abstract: The invention addresses the problem of correctly positioning a catheter and reducing radiation doses. It relates to an X-ray imaging system (1) for a robotic catheter, comprising said catheter (3), and a processing unit (5) for receiving X-ray images of a patient environment (15). By being adapted to receive one or more auxiliary information items and using said information for determining the catheter position, the processing unit does not entirely have to rely on a large number of scanned image data, thus helping to reduce radiation while correctly delivering the catheter position as a function of as few as a single image, preferably 2D, and said one auxiliary information items. Further, said processing unit allows for at least one of rendering an image and provide said image to a visualization device (21), and providing feedback, e.g. steering commands, to said robotic catheter.

Abstract: A fecal impaction removal device includes an elongated shaft extending along a central longitudinal axis. A dilation body is secured at a distal end of the elongated shaft for insertion into a rectum of a patient. The dilation body has a maximum radial extension in a direction orthogonal to the central longitudinal axis. The fecal impaction removal device includes a stop member that extends from a central region of the elongated shaft. The stop member has a length along a major axis that is greater than the maximum radial extension of the dilation body.

Abstract: A method and a system are provided for automatically delineating a striatum in a nuclear medicine brain image and calculating a striatum specific uptake ratio. In the method, initially, a target image is obtained. Then, the target image is projected to a space coordinate to generate a projection amount; an upper end and a lower end of a brain are obtained; and a preset range from the upper to the lower ends is set as a striatum slice area in the target image. A brain area is determined from the target image by a line detection method. Then, a brain volume template is deformed according to the brain area and the striatum slice area, so that a striatum in the brain volume template corresponds to the target image to delineate a striatum region of the target image. Finally, a specific uptake ratio of the striatum region can be calculated.

Abstract: According to one embodiment, an MRI apparatus includes sequence control circuitry and processing circuitry. The sequence control circuitry executes a pulse sequence for collecting MR signals in collection timings along a relaxation curve of longitudinal magnetization in synchronization with heartbeats or blood beats. The processing circuitry generate a T1 map representing a distribution of T1 values by using the collected MR signals. The pulse sequence is set so as not to collect any MR signal in at least one heartbeat or blood beat among heartbeats or blood beats included between first and second inversion pulses, and so as to collect an MR signal in a heartbeat or blood beat subsequent to the at least one heartbeat or blood beat in which no MR signal is collected.

Abstract: Cellular targets on cancer cells have been identified that can be used with targeted molecular imaging to detect the cancer cells in vivo. Non-invasive methods for detecting cancer cells, such as metastasized cancer cells, are therefore provided. Also provided are compositions and kits for use in the disclosed methods.

Abstract: A thermal accelerant is delivered to a tissue site and localized to modulate the shape, extent or other characteristic of RF or microwave-induced hyperthermia tissue ablation. The accelerant may be provided via an image-guided hand piece or via a lumen added to a microwave antenna, and promotes faster heating, more complete ablation and/or a more extensive treatment region to reduce recurrence of treated cancers, overcoming natural limitations, variations in tissue response and drop-off or thermal loss away from the antenna. The accelerant is delivered as a viscous but heat sensitive fluid, and is fixed in place to provide regions of preferential absorption or heating. Shorter exposure times to heat the far field may allow survival of vulnerable tissue such as vessels, and multiple antennae may be used for effective treatment of irregular or large tumors.

Abstract: The invention relates to an apparatus (1) for tracking a movable target (3), in particular tissue (5), the apparatus (1) comprising at least one applicator (7) for marking the target (3) with at least one type of markers (11), and at least one tracking system (9) which is adapted for monitoring at least the at least one type of markers (11). In order to provide an apparatus and a method for tracking a movable target (3), in particular tissue (5) which improve the reliability of the target tracking and which reduce the risk of damaging a target, it is intended according to the invention that the at least one applicator (7) is adapted for generating a randomly distributed pattern (13) of markers (11) on the target (3).

Abstract: An X-ray imaging method is for generating image data of a field of view of an object to be examined. In the method, firstly an individual imaging protocol is determined for imaging of the object to be examined. Furthermore, first X-ray projection measurement data with a first X-ray energy spectrum and at least one set of second contrast medium-influenced X-ray projection measurement data with a second X-ray energy spectrum, are acquired from the field of view. A third X-ray energy spectrum with a third mean energy is then determined on the basis of the determined individual imaging protocol. Subsequently, preferably pseudo-monoenergetic image data, associated with the third X-ray energy spectrum, is reconstructed on the basis of the acquired first and at least second X-ray projection measurement data as well as the determined imaging protocol. An image data-generating device is also described. A computerized tomography system is described, moreover.

Abstract: Systems and methods are disclosed for determining individual-specific blood flow characteristics. One method includes acquiring, for each of a plurality of individuals, individual-specific anatomic data and blood flow characteristics of at least part of the individual's vascular system; executing a machine learning algorithm on the individual-specific anatomic data and blood flow characteristics for each of the plurality of individuals; relating, based on the executed machine learning algorithm, each individual's individual-specific anatomic data to functional estimates of blood flow characteristics; acquiring, for an individual and individual-specific anatomic data of at least part of the individual's vascular system; and for at least one point in the individual's individual-specific anatomic data, determining a blood flow characteristic of the individual, using relations from the step of relating individual-specific anatomic data to functional estimates of blood flow characteristics.

Abstract: The present invention relates to visualizing vasculature structure.

Abstract: An ultrasonic diagnostic imaging system produces contrast enhanced images which are processed differently during different stages of contrast agent wash-in. During an initial stage of contrast wash-in, imaging is done using pixels processed by maximum intensity detection, to better reflect the rapid change in contrast intensity. During a later stage of contrast wash-in, time averaged processing is used to diminish the effects of noise and motion on the pixel values. During an intermediate period of peak enhancement, a combination of both pixel values processed by both techniques is used. In another aspect, a wash-in period can be characterized by an appearance stage, a growth stage and a peak stage, in which contrast pixel data is adaptively processed in different ways during these periods.

Abstract: A system and method for optical tomography including illuminating an object with pulsing stimulus light and pulsing the stimulus light at a repetition frequency having a pulse period that is greater than a dead-time of a detector. Coordinating the pulse with the dead-time of the detector allows for higher powered light source and improves early photon detection.

Abstract: A disclosed computer-implemented method may include directing a display device included in a head-mounted display worn by a user to illuminate, via a projection of a line at an illumination time, a portion of a cornea of the user. The method may further include detecting, via an image sensor at a detection time, a portion of the projection of the line reflected by the portion of the cornea of the user and identifying a distortion of the projection of the line reflected by the portion of the cornea of the user. The method may also include determining a shape of the cornea of the user based on the illumination time, the detection time, and the distortion of the projection of the line reflected by the portion of the cornea. Various other methods, systems, apparatuses, and computer-readable media are also disclosed.

Abstract: A device for manipulating an implant includes a handle coupled to a guide extending from the handle to a distal end. The device includes an engagement mechanism disposed at the distal end of the guide and configured to engage an implant. The device includes a first actuator disposed on the handle and coupled to the engagement mechanism. The first actuator causes the engagement mechanism to engage the implant. The device includes an air chamber disposed in an interior chamber of the handle and configured to hold air. The device includes a lumen coupled to the air chamber and extending along the guide to the distal end. The lumen includes an air channel extending through the lumen. The device includes a second actuator disposed on the handle. The second actuator causes the air chamber to deliver the air, via the air channel, to the distal end.

Abstract: A needle biopsy apparatus includes: a hollow needle for needling a patient; and a main body portion which retains the needle, and acquires a tissue of the patient through the needle. The needle is configured of gas not including a radioactive label, a liquid not including a radioactive label, or a solid not including a radioactive label, and includes a labelling portion of which a radiation dose to be detected is less than that of the tissue of the patient ingesting a radioactive-labelled radiopharmaceutical dosed to the patient, on a tip end side.

Abstract: Apparatus and methods are described for use with an imaging device (12) configured to acquire a set of angiographic images of a lumen. At least one processor (10) determines blood velocity within the lumen, via image processing. The processor determines a value of a flow-related parameter at the location based upon the determined blood velocity. The processor additionally receives an indication of a value of a second flow-related parameter of the subject, and determines a value of a luminal-flow-related index of the subject at the location, by determining a relationship between the value of the current flow-related parameter and the value of the second flow-related parameter. Other applications are also described.

Abstract: A digital image is captured. The captured digital image includes a calibration pattern. The calibration pattern includes displayed information about the calibration pattern. The displayed information is read to obtain calibration information about the captured digital image.

Abstract: In accordance with the teachings described herein, systems and methods are provided for generating a seed plan for use in radiation therapy. The system includes an image database, the image database comprising image slices and a seed template database comprising seed templates. A contour engine is configured to generate target contour data to identify one or more objects within each image slice. A reslicer engine is configured to rotate the contoured image about an angle of rotation to produce a resliced contoured image, such that the resliced contoured image is resampled at an angle perpendicular to the angle of rotation and intersecting an isocenter. The system also includes a seed grid engine configured to generate a seed grid perpendicular to the angle of rotation.

Abstract: Systems and methods for automatically triggering wireless power and data exchange between an external reader and an implanted sensor. The implanted sensor may measure the strength of an electrodynamic field received wirelessly from the reader and convey field strength data based on the measured strength of the received electrodynamic field to the reader. If the field strength data indicates that the strength of an electrodynamic field received by the sensor is sufficient for the implanted sensor to perform an analyte measurement, the reader may convey an analyte measurement command to the sensor, which may execute the analyte measurement command and convey measurement information back to the reader. The systems and methods may trigger the analyte measurement as the reader transiently passes within sufficient range/proximity to the implant (or vice versa).

Abstract: Guidance systems and associated methods are disclosed. One method comprises: receiving macroscan data prior to an operation; defining a body information model from the macroscan data; positioning a navigation component in the body during the operation; generating microscan data with the navigation component; correlating a location in the macroscan data with a location in the microscan data in the body information model; and/or modifying the body information model by combining an image in the microscan data with an image in the macroscan data.

Abstract: According to one embodiment, a medical image diagnosis apparatus includes an image acquisition unit, a data acquisition unit, a generation unit, and a display control unit. The image acquisition unit acquires medical image data of a plurality of time phases. The data acquisition unit acquires pixel value data of the time phases with respect to each of specified regions based on the medical image data. The generation unit generates display information based on the pixel value data of the time phases. The display control unit displays the display information in association with the regions in medical image data of an arbitrary time phase.

Abstract: A method and system for facilitating identification and marking of a target in a displayed Fluoroscopic Three-Dimensional Reconstruction (F3DR) of a body region of a patient. The system includes a display and a storage device storing instructions for receiving an initial selection of the target in the F3DR, fining the F3DR based on the initial selection of the target, displaying the fined F3DR on the display, and receiving a final selection of the target in the fined F3DR via a user selection. The system further includes at least one hardware processor configured to execute said instructions. The method and instructions may also include receiving a selection of a medical device in two two-dimensional fluoroscopic images, where the medical device is located in an area of the target, and initially fining the F3DR based on the selection of the medical device.

Abstract: Disclosed embodiments enable equipment and methodologies that generate a magnetic field using at least one coil under the control of a controller and transduce radio-frequency energy into lower-frequency current or voltage under control of the controller for application to tissue in a subject's body, whereby the transduction produces a lower-field current or voltage that has an effect upon the subject's body tissue.

Abstract: The invention relates to a beverage composition comprising: water; oxygen bubbles; a surfactant in an amount of between about 0.1% (v/v) and about 0.5% (v/v); one or more viscosity modifying agent(s) in an amount of between about 0.5% (v/v) and about 2.5% (v/v); and optionally citric acid in an amount of between about 0.1% (v/v) and about 0.5% (v/v). The invention further relates to compositions, methods of treatment for cancer, the composition for use in treatment of cancer, and the manufacture of the composition.

Abstract: An array emitter including a plurality of emitting portions can be used to individually emit selected energy, such as x-ray radiation, from the emitter ray rather than powering or emitting radiation from all portions of the emitter array. According, providing a plurality of cells within an emitter array, and selectively emitting x-rays from individual cells can allow for selection of which cells to emit x-rays from to acquire selected image data. A process is disclosed for selecting, including automatically, which portions to power to emit energy.

Abstract: The medical image processing apparatus includes a medical image acquisition unit that acquires a medical image; and a lesion detection unit that detects a lesion region in the medical image. The lesion detection unit includes a first identifier that identifies a lesion region candidate in the medical image and a second identifier that identifies whether the lesion region candidate identified by the first identifier is a blood vessel region, and detects the lesion region candidate that is not identified as the blood vessel region by the second identifier as the lesion region.

Abstract: A method for normalizing blood vessels of lesions is disclosed, which includes administering an effective amount of oxygen-loaded microbubbles to a subject in need by intravenous injection, and projecting ultrasound from a ultrasonic emission device into the lesions for rupturing the oxygen-loaded microbubbles and releasing the oxygen to the lesions. Each of the oxygen-loaded microbubbles comprises oxygen and a water insoluble gas, and the particle size of microbubbles is 0.5˜20 ?m.

Abstract: A method and system for integrated diagnostic testing and real-time treatment that includes a medical data gathering device to capture multiple of source images, where at least one of the source images contains a fiducial marker. The method and system incorporate a low latency encoder to encode the captured source images into a data stream and further includes an environmental sensor device for the capturing of sensor data. A processor is used to contextually modify the source images based on the captured sensor data and the fiducial marker and a transmitting device is used to transmit the contextually modified source images to a display device.

Abstract: A medical image-processing apparatus according to embodiments includes processing circuitry. The processing circuitry acquires volume data in which a blood vessel including a plurality of branch vessels leading to a plurality of target areas, respectively, is imaged. The processing circuitry extracts a blood vessel structure of the blood vessel included in the volume data. The processing circuitry sets a plurality of the target areas in the volume data. The processing circuitry acquires a plurality of delivery points that are points at which a drug is given to the target areas from a catheter moved inside the blood vessel based on the blood vessel structure of the blood vessel and a positional relationship between the respective target areas and the respective branch vessels in the volume data. The processing circuitry outputs the delivery points.

Abstract: A method and system for determining a radiopharmaceutical compound in a medical image is disclosed. In one embodiment, the method includes obtaining the medical image from a medical imaging device through an interface. The method also includes identifying a region of interest in the medical image. The method further includes generating a feature vector associable with the region of interest. Additionally, the method includes detecting an uptake of the radiopharmaceutical compound in the region of interest. Furthermore, the method includes identifying a type of the radiopharmaceutical compound in the region of interest based on the feature vector and a biological information associated with the region of interest.

Abstract: The present disclosure describes a non-linear compartmental model using PET-derived data to predict, on a patient-specific basis, the optimal therapeutic dose of cargo carrying antibody (e.g., huA33) such as radiolabeled antibody, the antigen occupancy, residency times in normal and malignant tissues, and the cancer-to-normal tissue (e.g., colorectal cancer-to-normal colon tissue) therapeutic index. In addition, the non-linear compartmental model can be readily applied to the development of strategies such as multi-step targeting (MST) designed to further improve the therapeutic indices of RIT.

Abstract: Disclosed aspects relate to the acquisition and processing of projection data using temporal characteristics of the imaged volume, such as the uptake and clearance of a contrast agent within the volume. Such temporal aspects may be used in the acquisition process, such as to differentially acquire images based on the propagation of the contrast agent. In addition, such temporal aspects may be used in the processing of projection data to generate differential projections (e.g., first or second order subtraction projections), compound projections synthesized using the absolute or relative maximum opacity values observed over time for a region of interest, or interpolated projections synthesized using observed opacity values at known or fixed time intervals and a derived peak opacity time.

Abstract: A medical information processing apparatus according to an embodiment includes processing circuitry. The processing circuitry obtains image data rendering a blood vessel of patient. The processing circuitry performs a fluid analysis on the obtained image data and calculates an index value related to a blood flow in the blood vessel with respect to each of a plurality of positions in the blood vessel. With respect to the index values to be calculated, the processing circuitry selects a position in which a first value is to be obtained from among the plurality of positions or selects a value serving as the first value from among the index values exhibited in positions. The processing circuitry causes a display to display the first value in a predetermined display region thereof used for displaying the first value.

Abstract: The present disclosure discloses an afterglow detection device and an afterglow detection method. The afterglow detection device comprises: an X-ray tube for emitting an X-ray beam; a first reading circuit for receiving a first detected signal from a to-be-detected detector to form and output a first measurement signal according to the first detected signal, the to-be-detected detector being connected to the first reading circuit and disposed on a beam-out side of the X-ray tube to receive radiation of the X-ray beam and outputting the first detected signal to the first reading circuit at the time of detection; a residual ray detector disposed on a beam-out side of the X-ray tube; a second reading circuit connected to the residual ray detector for receiving a second detected signal from the residual ray detector to form and output a second measurement signal according to the second detected signal.

Abstract: A method of planning a patient-specific cardiac procedure according to an embodiment of the current invention includes receiving three-dimensional imaging data of a patient's heart, simulating at least one of electrophysiological or electromechanical activity of at least a portion of the patient's heart using the three-dimensional imaging data, and planning the patient-specific cardiac procedure based on the simulating. The cardiac procedure is for providing a preselected alteration of at least one of electrophysiological or electromechanical behavior of the patient's heart.

Abstract: The disclosure provides a method and device for performing three-dimensional blood vessel reconstruction using angiographic images. The method includes an acquisition step that acquires a first two-dimensional image of the blood vessel in the first projection direction and a corresponding reconstructed three-dimensional model of the blood vessel.

Abstract: A frequency agile gyrotron for use in combination with an NMR system is disclosed. The frequency agile gyrotron combined with EPR-NMR magic angle spinning resonators and cryogenic sample cooling may increase the sensitivity of solid state NMR with DNP.

Abstract: Detector module designs for radiographic imaging include first and second layers of scintillator rods or pixel arrays oriented in first and second directions. The first and second directions are transversely oriented to define a light sharing region between the first and second layers. Encoding features may be disposed in, on or between the first and second layers, and configured to modulate propagation of optical signals therealong or therebetween.