Abstract: A wireless signal transmitter is provided for a radiotherapy device, said radiotherapy device being configured to provide radiation to a subject via a source of radiation, and further being configured to output a non-continuous beam of radiation, wherein said non-continuous beam of radiation has a first, time-related property associated therewith. The wireless signal transmitter is configured to wirelessly transmit a signal comprising data regarding the first, time-related property that is associated with the non-continuous beam of radiation, to a wireless signal receiver.

Abstract: Systems and methods are provided for provided for automated selection of UWFA images. A first set of images representing an early phase of a UWFA image acquisition and a second set of images representing a late phase of the UWFA image acquisition are received and segmented to provide a vascular structure map for each of the first set of images and the second set of images. An image quality metric is assigned to each of the first set of images and the second set of images from the vascular structure map associated with each image. An image of the first set of images having an extreme value for the image quality metric across the first set of images and an image of the second set of images having an extreme value for the image quality metric across the second set of images are selected.

Abstract: A method of x-ray fluoroscopy images a region of interest at distinct first and second imaging projection angles using digital subtraction x-ray fluoroscopic imaging with a fiducial marker board positioned in a field of view containing the region of interest to produce first and second sets of images. Image segmentation information is determined to identify an anatomical feature in the region of interest imaged in the first set of images and the second set of images. The region of interest is then imaged using x-ray fluoroscopic imaging, again with the fiducial marker board positioned in a third field of view containing the region of interest, but without digital subtraction, to produce a third set of images. A virtual image of the anatomical feature is projected onto the third set of images, computed from the image segmentation information and from a predetermined geometric relationship of markers within the fiducial marker board.

Abstract: Provided are an image generation device, an image generation method, an image generation program, a learning device, a learning method, and a learning program that can check an efficacy of a medicine. A processor acquires a medical image including a lesion and information related to a type of medicine to be administered to a patient, from whom the medical image has been acquired, and an administration period of the medicine. The processor generates, from the medical image, a post-administration image indicating the lesion after the medicine is administered to the patient for the administration period.

Abstract: A deep learning (DL) convolution neural network (CNN) reduces noise in positron emission tomography (PET) images, and is trained using a range of noise levels for the low-quality images having high noise in the training dataset to produce uniform high-quality images having low noise, independently of the noise level of the input image. The DL-CNN network can be implemented by slicing a three-dimensional (3D) PET image into 2D slices along transaxial, coronal, and sagittal planes, using three separate 2D CNN networks for each respective plane, and averaging the outputs from these three separate 2D CNN networks. Feature-oriented training can be implemented by segmenting each training image into lesion and background regions, and, in the loss function, applying greater weights to voxels in the lesion region. Other medical images (e.g. MRI and CT) can be used to enhance resolution of the PET images and provide partial volume corrections.

Abstract: In an imaging method, a first image is generated at a first capture time by an imaging apparatus, the first image representing part of an object to be depicted. A second image is generated at a second capture time after the first capture time, the second image representing the part of the object to be depicted. A further first image is generated based on the first image using a predefined model relating to a development over time of a contrast agent present in the object to be depicted when generating the first image, the further first image taking into account development over time of the contrast agent from the first capture time to the second capture time. A further second image is generated as a function of the second image and further first image, wherein an effect of the contrast agent on the second image is at least partially compensated.

Abstract: Systems and methods for estimating quantitative histological features of a subject's tissue based on medical images of the subject are provided. For instance, quantitative histological features of a tissue are estimated by comparing medical images of the subject to a trained model that relates histological features to multiple different medical image contrast types, whether from one medical imaging modality or multiple different medical imaging modalities. In general, the trained model is generated based on medical images of ex vivo samples, in vitro samples, in vivo samples or combinations thereof, and is based on histological features extracted from those samples. A machine learning algorithm, or other suitable learning algorithm, is used to generate the trained model. The trained model is not patient-specific and thus, once generated, can be applied to any number of different individual subjects.

Abstract: The present disclosure provides a system for functional ultrasound imaging, where the system comprises: a) an apparatus for delivering a nucleic acid encoding a mechanosensitive ion channel to a target neural cell population in a region of a brain; and b) a functional ultrasound imaging device. The present disclosure provides a method for functional ultrasound imaging.

Abstract: Systems and methods are described for using a combination of high-resolution, optical-sectioning imaging modalities to provide quantitative measures of the distribution of a contrast agent in tissue samples by identifying its cellular distribution. In some instances, the systems and methods may be used in an intraoperative setting to guide a biopsy or surgical procedure.

Abstract: A wearable system is disclosed, which may include a housing containing a processor, a network interface, a temperature sensor, an optical sensor, and an electromagnetic frequency generator. The system may further include a band connected to the housing for securing it to a user. The processor may be configured to receive muscle temperature and blood oxygen level data from the sensors, transmit the data to a remote device via the network interface, receive a bioresonance modality instruction from the remote device, instruct the electromagnetic frequency generator to emit an electromagnetic bioresonance frequency based on the instruction, and transmit updated muscle temperature and blood oxygen level data to the remote device. The system may enable remote monitoring and control of bioresonance to encourage the user's bioresonance state.

Abstract: A guide wire includes a core shaft having a distal end portion stepwisely decreasing in diameter, an inner coil body covering at least a part of an outer periphery of the distal end portion, an outer coil body covering an outer periphery of the inner coil body, and a distal end fixing portion that fixes distal ends of the core shaft. The distal end portion includes a small diameter portion, a large diameter portion inside the inner coil body and the outer coil body further in the proximal end direction than the small diameter portion and having a larger diameter than that of the small diameter portion, and a tapered portion that increases in diameter from the small diameter portion toward the large diameter portion. A radiopaque marker is on an outer peripheral surface of the tapered portion. A gap is between the radiopaque marker and the inner coil body.

Abstract: A method and apparatus for tracking disease progression as revealed by multiple lesions perform a global optimization to identify corresponding lesions by overlap, for example, after outlines of the lesions have been morphologically dilated. A clustering algorithm addresses the problem of lesions separating into parts or joining together to provide a clear picture of disease progression.

Abstract: A method for performing cardiology and endovascular interventional operations includes: Step 1, putting an artery sheath into a punctured artery; inserting a Pigtail catheter into a first end of the artery sheath, and advancing it to a left ventricle; injecting contrast into the Pigtail catheter to perform left ventricle angiography; and withdrawing the Pigtail catheter from the artery sheath. Step 2, inserting a guiding catheter into the first end of the artery sheath, and advancing it to the left ventricle. Step 3, advancing a myocardial biopsy forcep to a left ventricle endocardium through the guiding catheter to collect a piece of myocardium. Step 4, withdrawing the myocardial biopsy forcep from the guiding catheter, and preserving a myocardium specimen. Step 5, repeating steps 3 and 4 until collecting enough number of myocardium specimens. Step 6, withdrawing the guiding catheter from the artery sheath, and pulling the artery sheath out of the artery.

Abstract: Provided is a system, method, and computer program product for segmenting vessels in an ultrasound image. The method includes detecting edges of a vessel in the ultrasound image; detecting a vessel contour of the vessel in the ultrasound image based on the detected edges and a distance regularized level set evolution; and tracking the vessel contour with a Kalman Filter.

Abstract: A positioning arm apparatus for an ultrasound head is provided. The positioning arm apparatus for an ultrasound head according to an embodiment may constantly move the ultrasound head without change in height of the ultrasound head according to a moving distance by simultaneous rotation at two positions and tilting motion at one position. Also, the positioning arm apparatus may be miniaturized and lightweight since it is operated with a mechanical mechanism, and may provide strong fixing strong and easy maneuverability.

Abstract: A method and apparatus for marking a target with a radiopaque marker is disclosed. The method may include providing a radiopaque filament and inserting at least portion of the radiopaque filament into tissue. The filament may extend continuously and at last partially around a perimeter of the target so that the filament is disposed in a plurality of surgical planes to demarcate the target with the radiopaque maker.

Abstract: The present invention relates to a medical device having an improved ultrasound visibility and a very smooth surface, to methods for producing the device according to the invention and to the application of the device in therapeutic and diagnostic interventions. The improved ultrasound visibility is achieved by bubbles or closed cavities in an inner polymer layer.

Abstract: Techniques that facilitate three-dimensional (3D) delineation of tumor boundaries via one or more supervised machine learning algorithms are provided. An example embodiment includes a computer-implemented method that includes: extracting, by a computing system operatively coupled to a processor, one or more feature vectors from a time-series evolution of fluorescence distribution observed at a section of bodily tissue of interest, wherein the one or more feature vectors represent a physical model describing on-tissue dye dynamics of the section of bodily tissue; and generating, by the computing system, a classification attribute for the section of bodily tissue represented by the one or more feature vectors, wherein a pre-trained classifier designates the section of bodily tissue as a biopsy or a non-biopsy candidate through execution of the one or more supervised machine learning algorithms.

Abstract: A method of performing high-throughput radio thin layer chromatography (radio-TLC) includes spotting a plurality of locations on one or more TLC plates with samples containing a radiochemical or a radiopharmaceutical, each location defining an individual lane on the one or more TLC plates for the respective samples. The one or more TLC plates are developed with a developing solution and dried. The TLC plates are imaged with an imaging device comprising a camera, wherein the image obtained from the camera comprises a field of view that contains regions of interest (ROIs) from the plurality of lanes. The ROIs in the images obtained from the camera may then be analyzed by the user. The ROIs may be used, for example, reaction optimization or for quality control check of the production of radiotracers.

Abstract: A surgical visualization system is disclosed. The surgical visualization system is configured to identify one or more structure(s) and/or determine one or more distances with respect to obscuring tissue and/or the identified structure(s). The surgical visualization system can facilitate avoidance of the identified structure(s) by a surgical device. The surgical visualization system can comprise a first emitter configured to emit a plurality of tissue-penetrating light waves and a second emitter configured to emit structured light onto the surface of tissue. The surgical visualization system can also include an image sensor configured to detect reflected visible light, tissue-penetrating light, and/or structured light. The surgical visualization system can convey information to one or more clinicians regarding the position of one or more hidden identified structures and/or provide one or more proximity indicators.

Abstract: A networking-capable emergency tourniquet including an adjustable and inflatable cuff configured to encircle a limb of a patient, and a controller unit removably coupled to the inflatable cuff. The controller unit includes a microcontroller configured to control the introduction, removal, and maintenance of air within the inflatable cuff and process collected patient data, a communicator unit configured to communicate with the user, a transmitter configured to transmit the collected patient data to a centralized server over a communication network, and a receiver configured to receive information from at least one of the centralized server and other sources over the communication network.

Abstract: Methods and systems are provided for adaptive scan control. In one embodiment, a method includes, upon a first contrast injection of a first contrast bolus, processing acquired projection data of a subject to measure a contrast signal of the first contrast bolus, setting a timing for a second contrast injection of a second contrast bolus to a fallback injection timing, and responsive to identifying an adaptive injection timing for the second contrast injection based on the contrast signal before the fallback injection timing is reached, updating the timing for the second contrast injection to the adaptive injection timing and commanding initiation of the second contrast injection at the adaptive injection timing, otherwise commanding initiation of the second contrast injection at the fallback injection timing.

Abstract: Provided are systems for filling containers with radioactive and/or other types of potentially hazardous materials. In some aspects, the systems include a shielding material that substantially defines a chamber and, preferably, substantially blocks radioactivity, a conduit extending from outside to into the chamber, and a unit that is disposed in the chamber proximal to the conduit and is adapted to receive a capsule through the conduit. The systems of the present disclosure can further comprise a syringe, a syringe controller that is disposed in the dispensing chamber and adapted to meter an aliquot from a radioactive stock solution and inject the aliquot into the capsule or a vial.

Abstract: A method and system are used to enhance a marker material to include a plurality of air bubbles. The method of manufacturing a marker includes enhancing a marker material to include a plurality of air bubbles using at least a first EFD and a second EFD. The method may include cycling repeatedly through a transfer process between a first container and a second container. A system for enhancing a marker material includes a transfer apparatus configured to receive a marker material and a selected amount of air. The system comprises a first EFD coupled to a first end of the transfer apparatus and a second EFD coupled to a second end of the transfer apparatus.

Abstract: Described are devices, systems and methods for thermographic imaging of conditions of the ear, nose, and throat (ENT). An example device for thermographic ENT imaging includes an endoscope and a thermal imaging camera that can be either integrated or added as an attachment to the endoscope. The device may also include a mirror configured to direct thermal radiation emitted by a target area to the thermal imaging camera.

Abstract: An apparatus for determining a functional index for stenosis assessment of a vessel is provided. The apparatus comprises an input interface (40) and a processing unit (50). The input interface is configured to obtain image data (30) representing a two-dimensional representation of a vessel (6). The processing unit (50) is configured to determine a course of the vessel (6) and a width (w1, w2) of the vessel along its course in the image data and is further configured to determine the functional index for stenosis assessment of the vessel based on the width of the vessel in the image data.

Abstract: A method for enhancing a near-infrared fluorescence image includes providing a NIR fluorescence image produced by detecting light in the NIR-I or NIR-IIa windows emitted by fluorophores; and inputting the NIR fluorescence image to a convolutional neural network to produce as output a translated image, where the convolutional neural network is trained using a set of NIR-I or NIR-IIa fluorescence images and a set of NIR-IIb fluorescence images. Preferably, the convolutional neural network is a U-Net.

Abstract: A method and system for generating material decomposition images from plural-energy x-ray based imaging, the method comprising: modelling spatial relationships and spectral relationships among the plurality of images by learning features from the plurality of images in combination and one or more of the plurality of images individually with a deep learning neural network; generating one or more basis material images employing the spatial relationships and the spectral relationships; and generating one or more material specific or material decomposition images from the basis material images. The neural network has an encoder-decoder structure and includes a plurality of encoder branches; each of one or more of the plurality of encoder branches encodes two or more images of the plurality of images in combination; and each of one or more of the plurality of encoder branches encodes a respective individual image of the plurality of images.

Abstract: An image processing apparatus includes at least one processor. The processor is configured to execute processing of acquiring a first image as a radiographic image including an image of a subject generated by radioscopy for continuously irradiating the subject with radiation to perform imaging, acquiring a second image different from the radiographic image including the image of the subject before acquiring the first image, specifying a subject region as a region where the image of the subject is formed in the first image, based on the second image, and executing image processing of enhancing contrast of the specified subject region on the first image and outputting the first image after the image processing.

Abstract: Method and systems for determining acceptance criteria for identification of occluding particles in a lumen of a device are provided. The methods and systems can be used in methods of identifying an occluded device in an inspection method. The acceptance criteria can be calculated based on mass flow measurements of an occluded representative device.

Abstract: A system uses range and Doppler velocity measurements from a lidar system and images from a video system to estimate a six degree-of-freedom trajectory of a target. The system estimates this trajectory in two stages: a first stage in which the range and Doppler measurements from the lidar system along with various feature measurements obtained from the images from the video system are used to estimate first stage motion aspects of the target (i.e., the trajectory of the target); and a second stage in which the images from the video system and the first stage motion aspects of the target are used to estimate second stage motion aspects of the target. Once the second stage motion aspects of the target are estimated, a three-dimensional image of the target may be generated.

Abstract: A thermal accelerant is delivered to a tissue site and localized to modulate the shape, extent or other characteristic of RF or microwave-induced hyperthermic tissue ablation. The accelerant may be provided via an image-guided hand piece or via a lumen added to a microwave antenna, and promotes faster heating, more complete ablation and/or a more extensive treatment region to reduce recurrence of treated cancers, overcoming natural limitations, variations in tissue response and drop-off or thermal loss away from the antenna. The accelerant is delivered as a viscous but heat sensitive fluid, and is fixed in place to provide regions of preferential absorption or heating. Shorter exposure times to heat the far field may allow survival of vulnerable tissue such as vessels, and multiple antennae may be used for effective treatment of irregular or large tumors.

Abstract: A method and/or system are provided for improving kidney function and/or increasing Glomerular Filtration Rate (GFR) of the renal system, by applying acoustic and/or ultrasonic energy to one or more of the kidneys. The method suggests either focused or non-focused (or combined) energy delivery, optionally in a noninvasive approach, which could also be implemented invasively and/or by implantable device. Potential applications of this technique, include, but are not restricted to, treatment of renal disorders such as CKD (Chronic Kidney Disease) and/or AKI (Acute Kidney Injury), short term or long term intervention in kidney function for therapeutic or diagnostic purposes, modifying urine output in heart failure, modulating blood volume and/or pressure, and modulating clearance of compounds in the blood are typically difficult to extract from the kidneys, such as iodine, other imaging contrast media, and similar compounds.

Abstract: A virtualization infrastructure control device (10) includes: a monitoring unit (13) for acquiring load information regarding a resource; a scaling control unit (11) for determining, based on the load information, whether or not to perform scaling and calculating a resource amount required for the scaling; and a resource delivery control unit (12) for converting the resource amount required for the scaling to a change number for the number of allocated CPUs regarding a CPU core that is a resource allocated to VM-by-VM, selecting the change number of CPU cores that are to be subjected to the scaling, and transmitting, to a compute, resource change instruction information including information regarding the selected CPU cores whose allocation is to be changed.

Abstract: An illustrative surgical system may access a plurality of images captured outside a structure within a patient; detect a difference between spectral reflectances of scenes captured in the plurality of images; and identify, based on the detected difference between the spectral reflectances of the scenes captured in the plurality of images, pixels in at least one of the plurality of images that correspond to structure tissue of the structure.

Abstract: A flexible oximeter device for measuring pulse and blood oxygen saturation in tissue includes a first array of first light emitting elements that emit red light, a second array of second light emitting elements that emit green light or near-infrared (NIR) light and an array of sensor elements arranged on at least one flexible substrate. Each sensor element is configured to detect red and green or NIR light, and to output a signal representing an amount of red or green or NIR light detected. The first and second arrays and the array of sensor elements form a plurality of interleaved measurement pixels, each pixel comprising one of the first light emitting elements and a corresponding sensor element, and one of the second light emitting elements and a different corresponding sensor element.

Abstract: A composite scaffold having a highly porous interior with increased surface area and void volume is surrounded by a flexible support structure that substantially maintains its three-dimensional shape under tension and provides mechanical reinforcement during repair or reconstruction of soft tissue while simultaneously facilitating regeneration of functional tissue.

Abstract: A system for transcranial magnetic resonance (MR)-guided focused ultrasound and method of using transcranial MR-guided focused ultrasound are disclosed. The system includes a transcranial ultrasound transducer configured to apply ultrasound radiation to a patient's head. The system also includes an antenna that reflects radio frequency (RF) waves. The antenna is configured to be positioned between the transducer and the patient's head. The antenna and at least a portion of the patient's head are surrounded by a fluid. Embodiments foster improved MR image quality scans of the patient's head when the transducer is filled with the fluid.

Abstract: A hand-control device for controlling the operation of an injection system is described herein. The hand-control device includes one or more input components that receive input to control various operations of the injection system, including commanding the injection to perform a particular operation, changing an operational aspect of the injection system, and selecting an operational mode for the injection system. A communication unit of the hand-control device generates and conveys a signal for the injection system, and receives a command signal from the injection system. An output component outputs an indication, such as a light emission, a sound, or haptic feedback, in response to receiving the command signal. In some instances, this indication acts as a confirmation or failure of the intended input.

Abstract: The present invention relates to a portable device for measuring skin condition and a skin condition diagnosis and management system using same. The device for measuring skin condition according to the present invention is a portable type of device that can be easily carried by a user, and when an image of a user's face is captured, can acquire a clear image of the entire face of the user by effectively controlling the user's face position.

Abstract: A method for determining lung function in a patient is disclosed, in which a multi-lumen catheter with an expandable occluding element at its end is used to isolate a targeted lung compartment, and respiratory characteristics at the targeted lung compartment are measured over multiple respiratory cycles. The relation between various characteristics of the respiratory cycle is used to determine compliance of lung tissue within the targeted lung compartment.

Abstract: A body mountable robot may include a set of stages disposed in a parallel configuration. The body mountable robot may include a set of actuating joints, wherein an actuating joint, of the set of actuating joints, is configured to rotate with respect to a corresponding stage of the set of stages. The body mountable robot may include at least one actuator, wherein the at least one actuator is configured to actuate at least one actuating joint of the set of actuating joints. The body mountable robot may include a set of scissor mechanisms, wherein a scissor mechanism, of the set of scissor mechanisms, that is coupled to the actuating joint, is supported by the corresponding stage, and wherein the scissor mechanism is configured to translate with respect to the corresponding stage.

Abstract: A phantom design method includes a correction step and a calculation step. In the correction step, an absorption spectrum of a target of spectroscopic measurement by a near infrared spectrometer is corrected based on a refractive index of the target and a refractive index of a resin used as a base material of a phantom to generate a corrected absorption spectrum. In the calculation step, based on an absorption spectrum of the resin and an absorption spectrum of each of N types of dyes, a concentration of each of the N types of dyes to be contained in the base material is calculated such that an absorption spectrum of the phantom constituted by the base material containing the N types of dyes approximates the corrected absorption spectrum in a predetermined wavelength range of a near infrared region.

Abstract: Described herein are systems, media, and methods for assessing an individual by generating a classification or regression based on input data comprising metabolite information, protein information, nucleic acid information, non-molecular information, or any combination thereof.

Abstract: Methods and systems for identifying CNV membranes and vasculature in images obtained using noninvasive imaging techniques are described. An example method includes generating, by a first model based on at least one image of a retina of a subject, a membrane mask indicating a location of a CNV membrane in the retina. The method further includes generating, by a second model based on the membrane mask and the at least one image, a vasculature mask of the retina of the subject, the vasculature mask indicating CNV vascularization in the retina.

Abstract: Methods and apparatus for analyzing optical measurements to determine whether a liquid includes dissolved oxygen, to determine a predicted concentration of the dissolved oxygen in the liquid, and/or to determine additional or alternative feature(s) related to dissolved oxygen in the liquid. An optical source can be controlled to emit optical radiation into a container that contains the liquid. The optical source can be located outside of the container, and the optical radiation includes (e.g., is restricted to) radiation that conforms to a dissolved oxygen absorption band. The optical radiation can be pulsed or can be periodically intensity modulated. A photodetector, located outside of the container but in optical communication with the interior of the container, can generate the optical measurements used in the analysis.

Abstract: A tissue implantation device comprises a capsule; and a population of ultrasound-switchable fluorophores incorporated in the capsule. A method of imaging a tissue implantation device in a biological environment comprises disposing the tissue implantation device in a biological environment, the population of ultrasound-switchable fluorophores having a switching threshold in the biological environment; exposing the biological environment to an ultrasound beam to form an activation region within the biological environment; switching the ultrasound-switchable fluorophores in the activation region from an off state to an on state; exciting the ultrasound-switchable fluorophores in the activation region with a beam of electromagnetic radiation; and detecting light emitted by the ultrasound-switchable fluorophores.

Abstract: The present invention provides a targeted nanoplex platform for in vivo imaging and theranostic imaging of cancer to simultaneously provide non-invasive assessment of tumor burden and cancer-selective treatments.

Abstract: Methods for performing certain medical procedures wherein a steerable endoluminal punch is used to not only gain access but to create a channel or punch through tissue, thus facilitating follow-up therapeutic procedures. The distal end of the steerable endoluminal punch is controllably articulated by the operator using a control device at the proximal end.

Abstract: An image recognition device and method retrieve information on a marker. The marker encodes information identifying an asset by encoding the information in a binary pattern as recesses and non-recesses in the marker. The image recognition is performed by imaging the marker, mapping contrast in the image, identifying variations in the contrast, creating a mesh overlaying the image, identifying the present or absence of recesses from the mesh, and reading the binary pattern represented by the recesses in the marker.