Abstract: According to one aspect, a system for intraoperatively providing anatomical guidance in a diagnostic or therapeutic procedure is disclosed. In one embodiment, the system includes: a first light source configured to emit a beam of visible light; second light source configured to emit a beam of near-infrared light; a handheld probe optically coupled to the second light source; a second imaging device configured to detect visible light; a third imaging device configured to detect near-infrared light having a first predetermined wavelength; a fourth imaging device configured to detect near-infrared light having a second predetermined wavelength; a display for displaying at least one visual representation of data; and, a controller programmed to generate at least one real-time integrated visual representation of an area of interest and to display the real-time visual representation on the display for guidance during the diagnostic or therapeutic procedure.

Abstract: The present invention is an image processing apparatus that reconstructs one frame of image data using block-level image data, including a unit that receives the block-level image data to which position information has been added, a unit that determines whether or not there was an error in the transmission of the received position information, a first storage area used for storing the block-level image data corresponding to the position information for which a transmission error did not occur, a second storage area used for storing the block-level image data corresponding to the position information for which a transmission error occurred, a unit that infers correct position information for the block-level image data stored in the second storage area based on the first storage area and the second storage area, and a unit that reconstructs the one frame of image data using the inferred position information.

Abstract: A method generates a three dimensional (3D) model of a tubular organ having an occluded segment. The occluded segment adjoins a proximal segment at a proximal end thereof, and a distal segment at a distal end thereof. The procedures included injecting a first dye injection into the tubular organ, the first dye approaching a first end of the occluded segment. Multiple first-injection two-dimensional (2D) images of the tubular organ are acquired, each acquired from a different perspective, the first-injection 2D images further acquired with a respective organ timing signal reading. A second dye is injected into the tubular organ, the second dye approaching a second end of the occluded segment. Multiple second-injection 2D images are acquired of the tubular organ, each acquired from a different perspective, the second-injection 2D images further acquired with a respective organ timing signal reading.

Abstract: Sizing an internal body structure in a patient includes guiding a sizing mechanism via a wire guide to a target location within the internal body structure, inflating a balloon of the sizing mechanism at the target location, and injecting a contrast fluid into the internal body structure. The inflated balloon blocks a flow of the injected contrast fluid to indicate that a size of the inflated balloon is accordant with a size of the body structure. Related apparatus is also disclosed.

Abstract: A contrast-enhanced imaging of an object is performed by an imaging device having a movable radiation source. A first projection image sequence of the object along a first trajectory over which the radiation source moves is recorded by radiation having a first energy spectrum. Subsequently, a second projection image sequence of the object along a second trajectory over which the radiation source moves is recorded by radiation having a second energy spectrum. A reconstruction of a three-dimensional subtraction image in relation to the different energy spectra is carried out by the first and second projection image sequence. In addition, a two-dimensional subtraction image in relation to the different energy spectra is reconstructed with the aid of the first and second projection image sequence. In this way, apart from a three-dimensional subtraction image, a two-dimensional subtraction image is also provided for better analysis of object characteristics.

Abstract: Contrast administration data that relates to operation of a contrast media injector system (602) may be converted from at least one format (e.g., a CAN-compliant format) to at least one other format (e.g., an HL-7-compliant format) for use by a medical system (600). Data on contrast media prescribed for an imaging operation using an imaging system (690), data on contrast media dispensed from a contrast media storage/dispensing unit (500) for use in this imaging operation, and data on contrast media actually administered/injected by a contrast media injector system (602) for this imaging operation may be stored in a data structure (780). Patient renal function data may be used to control the dispensing of contrast media from the contrast media/storage/dispensing unit (500), to control the operation of the contrast media injector system (602), or both, and may be stored in the data structure (780) as well.

Abstract: A liquid injector (400) injects a medical liquid into a patient whose fluoroscopic image data is to be picked up, and generates injection history data corresponding to the injection. A control box (500) allocates identification data associated with the fluoroscopic image data to the injection history data, and PACS (300) stores the fluoroscopic image data and the injection history data allocated with the identification data. The injection history data is also stored in association with the fluoroscopic image data to be stored, and hence the injection history data can also be confirmed when viewing the fluoroscopic image data.

Abstract: A marker delivery device is configured for deploying a tissue marker. The marker delivery device includes a handle having a chamber, and a cannula. According to one aspect, the cannula has a flexible portion formed by a slot arrangement having of a plurality of spaced-apart substantially parallel peripheral slots extending through the side wall of the cannula to the lumen. A marker introducer rod is movably disposed in the lumen of the cannula for deploying the mark, and has a flexible region that corresponds to the flexible portion of the cannula. According to another aspect, a retraction mechanism is mounted to the handle and is configured to facilitate a complete retraction of both the cannula and the marker introducer rod into the chamber of the housing of the handle upon an actuation of the retraction mechanism.

Abstract: A method for treating a spine disorder includes providing a bone fastener including a distal portion and a proximal portion including an axial opening and defining a longitudinal passageway. At least one lateral opening is disposed in communication with the longitudinal passageway. The axial opening is disposed in communication with the longitudinal passageway. The distal portion is engaged with a first vertebral surface. The second vertebral surface is spaced apart from the first vertebral surface. A radiopaque biologic is introduced through the axial opening and into the longitudinal passageway and delivered to a surgical site adjacent the first vertebral surface and the second vertebral surface. Systems for treating a spine disorder are disclosed.

Abstract: A method of tracking specific cells in vivo is disclosed. The method of the disclosure includes: providing fluorescent nanoparticles suitable for targeting of specific cells; administering the fluorescent nanoparticles to a subject; providing an X-ray source to irradiate the subject; and determining the distribution and growth of the specific cells by the fluorescent images from the fluorescent nanoparticles and X-ray images of the subject irradiated by the X-ray source.

Abstract: Provided herein are dual contrast agents or nanocomposite particles designed to enhance optoacoustic-ultrasonic imaging. The contrast agents or particles have a core designed to enhance response to incident transient ultrasonic pressure waves and at least two layers disposed around the core. The inner first layer is designed to effectively absorb incident transient optical waves, convert absorbed optical energy into heat and demonstrates significant thermal expansion and/or conversion of thermal energy into acoustic pressure. The outer second layer thermally insulates the inner layer from the surrounding aqueous environment and enhances the generation of transient ultrasonic pressure waves during optoacoustic-ultrasonic imaging and sensing. Also provided are methods of enhancing contrast in a tissue optoacoustic-ultrasonic imaging and producing enhanced optoacoustic images by contacting the tissue with the dual contrast agent or nanocomposite particles.

Abstract: A method is provided including obtaining ultrasound information including anatomy information representative of a portion of anatomy to be imaged and artifact information representative of a coherent interference artifact. A contrast agent has been associated with the coherent interference artifact. Due to association with the contrast agent, the coherent interference artifact appears in different realizations in a plurality of readings taking along a single line. The method also includes suppressing the artifact information to form revised ultrasound information. Suppressing the artifact information includes using the plurality of readings to suppress the artifact information. Also, the method includes reconstructing the ultrasound image using the revised ultrasound information.

Abstract: A method for characterizing tissue of a patient, including receiving acoustic data derived from the interaction between the tissue and the acoustic waves irradiating the tissue; generating a morphology rendering of the tissue from the acoustic data, in which the rendering represents at least one biomechanical property of the tissue; determining a prognostic parameter for a region of interest in the rendering, in which the prognostic parameter incorporates the biomechanical property; and analyzing the prognostic parameter to characterize the region of interest. In some embodiment, the method further includes introducing a contrast agent into the tissue; generating a set of enhanced morphology renderings of the tissue after introducing the contrast agent; determining an enhanced prognostic parameter from the enhanced morphology renderings; and analyzing the enhanced prognostic parameter.

Abstract: A catheter is provided with increased flexibility and radiopaque measurement visibility. The radiopaque measurement bands are formed of a continuous coil of radiopaque material defined by areas of tightly packed coils spaced by areas of loosely wound coils. Systems and methods of utilizing the measurement structure are also provided.

Abstract: These are subcutaneous cavity marking devices and methods. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammographic, echogenic, or other non-invasive imaging techniques. Also, the device contains a bioabsorbable or non-bioabsorbable marker. The device may be combined with various substances enhancing the radiopaque, mammographic, or echogenic characteristics of the marker or the body allowing it to be observed by any non-invasive imaging techniques. This is further a method of marking a subcutaneous cavity using a bioabsorbable material and a bioabsorbable or non-bioabsorbable marker in conjunction with the material. The method also may combine any of the features as described with the device.

Abstract: A scanning apparatus, is used to effect multiple images of a tumor in which a contrast agent has been localized as a detectable marker over a selected time to map the change in the imaged marker. The rate of change in the imaged marker and/or contrast intensity of the dyed tissues is used to assess tumor aggressiveness and as an early predictor of response to cancer therapy. In particular, following the marking of tumor or cancerous tissues by the initial localization of an imageable contrast agent, the rate of change in the volume and/or area of the imaged marker is used to provide an indication of tumor interstitial fluid pressure (TIFP).

Abstract: A method is proposed for simple and quick setting of an injection pump for image recording. In at least one embodiment of the method, patient-specific and appliance-specific input parameters are entered and a contrast agent protocol is created from the patient-specific and appliance-specific input parameters, by computer, by way of a functional relationship, and the contrast agent protocol is output to the injection pump. Furthermore, a computer unit is provided in at least one embodiment, with the aid of which the method is carried out.

Abstract: A probe for detecting K-alpha photon emissions. A housing has an aperture at an end. A detector crystal is situated within the housing adjacent to the housing aperture. An energy conversion device is situated within the housing between the detector crystal and the aperture. The energy conversion device is made from a predetermined material configured to convert energy directed through the housing aperture from a source of primary photon emission radiation to a corresponding secondary K-alpha emission within a predetermined emission energy acceptance window. A power supply is coupled to the detector crystal and is configured to establish a polarized electrical field between the anode and the cathode of the detector crystal. The detector crystal receives the K-alpha emission and generates an electrical signal representative of the amount of target emissions received through the housing aperture.

Abstract: Techniques, systems, devices and materials are disclosed for implementing and fabricating drug delivery and imaging vehicles, which are activated in the body at a tissue of interest by focused ultrasound. In one aspect, a drug delivery vehicle can include a carrier having an outer membrane that envelopes an acoustic sensitizer particle and a payload substance to be delivered to the target tissue. The outer membrane can protect the acoustic sensitizer particle and the payload substance from degradation and opsonization. The outer membrane can be functionalized with a tumor targeting ligand to cause the drug delivery vehicle to selectively accumulate in a tumor region over other tissues, as well as with an agent to increase circulation time by reducing uptake from undesired body tissues, organs, and systems.

Abstract: Using a three-dimensional medical image representing a heart as input, a cardiac function analysis unit calculates a cardiac function evaluation value representing a cardiac function with respect to each of predetermined portions of the heart, using a three-dimensional medical image representing the heart as input, a myocardial infarction analysis unit calculates a myocardial infarction rate representing a degree of myocardial infarction with respect to each of predetermined portions of the heart, and a superimposed image output unit outputs a superimposed image representing the cardiac function evaluation value and the myocardial infarction rate in a superimposing manner such that they are distinguishable from each other in a coordinate system capable of representing each position of the heart in the three-dimensional medical image.

Abstract: Embodiments of the present disclosure are configured to assess the severity of a blockage in a vessel and, in particular, a stenosis in a blood vessel. In some particular embodiments, the devices, systems, and methods of the present disclosure are configured to assess the severity of a stenosis in the coronary arteries utilizing external imaging.

Abstract: Some embodiments of this disclosure relates to systems and methods for imaging a patient's vasculature. For example, near infrared (NIR) light can be used to illuminate a target area and light that is reflected or scattered from the target area can be used for generate an image of the target area. In some embodiments, the system can be configured such that the image shows the presence, absence, or extent of infiltration or extravasation in the target area. The system can be configured to document that presence, absence, or extend of infiltration or extravasation at an infusion site. In some embodiments, an imaging system can be mounted onto a patient so that the imaging system can monitor an infusion site, and the imaging system can be configured to automatically detect the presence of infiltration or extravasation.

Abstract: A radiological imaging apparatus (10) acquires a radiological brain image of a subject after administration of a radio tracer binding to a target substance indicative of a clinical pathology. In one embodiment, the clinical pathology is amyloid deposits in the brain at a level correlative with Alzheimer's disease and the target substance is amyloid deposits. A processor (C) tests for the clinical pathology by: performing non-rigid registration of the brain image with a positive template (32P) indicative of having the clinical pathology and with a negative template (32N) indicative of not having the clinical pathology; generating positive and negative result metrics (36P, 36N) quantifying closeness of the registration with the positive and negative template respectively; and generating a test result (54) based on the positive result metric and the negative result metric. An independent test result is generated by quantifying a second mode of an intensity histogram for the brain image.

Abstract: A method of securing a biopsy marker within a biopsy site includes depositing a marker element within a biopsy site and fixing the marker element within the biopsy site by injecting a securing agent within the biopsy site. Delivery devices for delivering the securing agent to the biopsy site are also disclosed.

Abstract: A retrograde flow system is configured for treating an artery. The system includes an arterial access device adapted to be introduced into an artery and receive blood flow from the artery. A shunt fluidly is connected to the arterial access device, wherein the shunt provides a pathway for blood to flow from the arterial access device to a return site. A flow control assembly is coupled to the shunt and is adapted to regulate blood flow through the shunt between at least a first blood flow state and at least a second blood flow state. A shut-off valve assembly automatically blocks fluid flow through the shunt in response to injection of the fluid into the arterial access device.

Abstract: A system for at least partially filling and marking a cavity at a site within a patient's body includes a marker delivery device having a chamber configured to contain a marking substance and having a mechanism configured to expel the marking substance. A quantity of the marking substance is contained within the chamber of the marker delivery device. The marking substance is configured to at least partially fill the cavity and form therein a porous bioabsorbable body. A delivery tube is coupled in fluid communication with the chamber of the marker delivery device. The delivery tube has a distal end with a discharge port through which the marking substance is expelled. A marker is configured to be delivered to the cavity from the distal end of the delivery tube and is configured to remain with the porous bioabsorbable body within the cavity upon the formation thereof.

Abstract: A device for percutaneously excising tissue. In an embodiment, the device comprises an outer tubular. In addition, the device comprises an inner tubular slidingly received within the outer tubular, wherein the inner tubular has a distal end including an upper member and a lower member.

Abstract: Methods for computing hemodynamic quantities include: (a) acquiring angiography data from a patient; (b) calculating a flow and/or calculating a change in pressure in a blood vessel of the patient based on the angiography data; and (c) computing the hemodynamic quantity based on the flow and/or the change in pressure. Systems for computing hemodynamic quantities and computer readable storage media are described.

Abstract: The invention provides a device for percutaneously implanting an imaging marker for identifying a location within a tissue mass. The subcutaneous imaging marker comprises at least a first element and a second element, each of which have a primary imaging mode. The primary imaging mode of the first element is different from that of the second element.

Abstract: According to one embodiment, an image processing apparatus includes following units. The correspondence table describes a relationship between blood vessel contrasts and reference contrast medium concentrations and reference X-ray conditions. The acquisition unit acquires a blood vessel contrast by referring to the correspondence table based on the planned value of a contrast medium concentration and the X-ray condition. The calculation unit calculates a predictive pixel value of a region of interest set on the X-ray image based on the blood vessel contrast. The display unit displays the X-ray image while superimposing a partial image with the predictive pixel value on the region of interest.

Abstract: Provided herein is a method for treating spinal stenosis comprising percutaneously accessing the epidural space from a first side of the spine. The first side of the spine is located on one side of the medial plane with respect to the spinal cord. A tissue removal tool is then advanced through the first side of the epidural space into the other side of the epidural space, where the other side of the epidural space is located on the other side of the medial plane of the spinal cord. Once the tissue removal tool is located on the second side of the medial plane, stenosis can be reduced using the tissue removal tool.

Abstract: Embodiments provided herein relate to ionizing radiation detectors for use with endoscopic ultrasounds. In some embodiments, an apparatus is provided and includes an ultrasound transducer and an ionizing radiation detector, such as a scintillating detector. The ionizing radiation detector can comprise a scintillating material and a photodetector.

Abstract: A computed tomography (CT) or ultra sound imaging system and method are configured to construct images of an object. The imaging system includes: a radiation or ultrasound source including a collimating or a blocking device configured to generate both a narrow beam and a wide beam; a detector configured to detect radiation or ultrasound wave from the radiation or ultrasound wave from the radiation or ultrasound source; and at least one processing circuit configured to: determine a scatter-to-primary ratio (SPR) of the wide beam based on the narrow beam; determine a primary component of the wide beam based on the SPR to thereby separate the primary component from a scattered component of the wide beam; and construct an image of an object inside a patient using the primary component to thereby improve a contrast of the object.

Abstract: An intracorporeal marker includes a fibrous unitary marker body having bioabsorbable fibers compressed into a compressed configuration, and bound in the compressed configuration by a polymer binding agent. The intracorporeal marker may be incorporated into an intracorporeal marker delivery device having a delivery cannula which has a distal tip, an inner lumen and a discharge opening in communication with the inner lumen. The compression and binding occur prior to insertion of the fibrous unitary marker body into the inner lumen of the delivery cannula. The fibrous unitary marker body is slidably disposed within and pushable through the inner lumen of the elongated delivery cannula proximal to the discharge opening.

Abstract: The invention provides materials, devices and methods for marking biopsy sites for a limited time. The biopsy-marking materials are ultrasound-detectable bio-resorbable powders, with powder particles typically between about 20 microns and about 800 microns in maximum dimension, more preferably between about 300 microns and about 500 microns. The powders may be formed of polymeric materials containing cavities sized between about 10 microns and about 500 microns, and may also contain binding agents, anesthetic agents, hemostatic agents, and radiopaque markers. Devices for delivering the powders include tubes configured to contain the powders and to fit within a biopsy cannula, the powders being ejected by action of a syringe. Systems may include a tube containing powder, and a syringe containing sterile saline. The tube may be configured to fit within a biopsy cannula such as a Mammotome® or SenoCor 360™ cannula.

Abstract: A method of evaluating tissue of an organ includes performing at least one of classification processing and clustering processing to obtain a processed dataset to visualize at least one of the imaging agent, blood, the contrast agent, and the biomedical agent distribution in the tissue, a relative regional uptake of the at least one of the imaging agent, blood, the contrast agent, and the biomedical agent in the tissue, relative regional flow of the at least one of the imaging agent, blood, the contrast agent, and the biomedical agent and the clearance or persistence of the at least one of the imaging agent, blood, the contrast agent, and the biomedical agent within the tissue and the characterization of elemental components of disease.

Abstract: Provided are multi-segmented inflatable brachytherapy devices. Also provided are systems and methods including multi-segmented inflatable brachytherapy devices.

Abstract: A device and an agent for performing imaging in a deep part with high sensitivity and high resolution are to be provided. A photoacoustic measurement device (photoacoustic imaging device) performs light irradiation on an inspection area of a subject to which a photoacoustic agent generating an acoustic signal by causing phase change from a solid phase or a liquid phase to a gas phase by the light irradiation is administered, while the irradiated energy amount is increased, and detects the acoustic signal generated in the inspection area due to the light irradiation to form an imaged image of the inspection area based on the detected acoustic signal.

Abstract: The invention relates to x-ray imaging technology as well as image post-processing. Particularly, the present invention relates to post-processing of perfusion image data acquired by an x-ray imaging apparatus by absolutely or relatively normalizing perfusion image data to allow a preferred comparison of the image data, both with regard to different acquisitions as well as different patients. To allow normalization of perfusion image data, it may be desirable to know the amount of contrast agent injected, which remains in a coronary. Subsequently, image parameters may be adapted or normalized based on the known amount of contrast agent within the coronary for normalization of perfusion image data. To obtain a precise amount of injected contrast agent, the injected volume of contrast agent flowing through a defined region or section of a vessel may be estimated. Said injected volume of contrast agent may thus be deduced from the estimation of the total volume flow at this location.

Abstract: A method is disclosed for generating at least one x-ray image of a patient having incorporated contrast medium, using x-rays having an energy spectrum and an x-ray detector. The energy spectrum is modified by at least one first filter arranged in the beam path in front of the patient, the patient absorbing a dose in order to generate detector data for the x-ray image and the x-ray image having a CNR value which represents the ratio of the maximum contrast in the image to the noise. The energy spectrum and contrast medium are matched to each other, taking into account the thickness of the patient to be x-rayed, in such a way that an optimization criterion which is taken from an x-ray image that is generated or simulated by way of trials is maximized. Furthermore, an x-ray system is also disclosed.

Abstract: The present invention relates to methods and devices for predicting restenosis, and for treating atherosclerosis to prevent or reduce the incidence of restenosis. Methods of predicting restenosis in a stenosed peripheral artery may include quantitative histology of the vessel. For example, a method of treating a stenosed artery (and particularly a peripheral artery) may include the steps of determining a level of hypercellularity and one or more of the lipid-richness and extent of inflammatory cell inclusion in the tissue. An index of restenosis based on the hypercellularity and lipid richness and/or extent of inflammatory cell inclusion in the tissue may be determined. Systems for treating or preventing restenosis may include one or more imaging modalities for imaging tissue regions and determining the level of hypercellularity and one or more of the degree of lipid-richness and the extent of inflammatory cell inclusion in the tissue region.

Abstract: A system and method for confocal imaging of tissue in vivo and in situ, e.g., for minimally invasive diagnosis of patients. A catheter is provided that has a dye carrier coupled to the distal end of a fiber optics bundle, which allows for the introduction of at least one fluorescent dye therein the dye carrier into a portion of the tissue of interest of a subject or patient when the dye carrier is selectively brought into contact with the portion of the tissue of interest. The resulting confocal images permit the acquisition of diagnostic information on the progression of diseases at cellular/tissue level in patients. Furthermore, a system for ECG-triggered image acquisition is provided.

Abstract: Medical devices that are visible by magnetic resonance imaging (MRI), and optionally, other imaging techniques, are described. In some embodiments, a medical device adapted for insertion into the body includes an elongated shaft and an electrically conductive path extending spirally about a portion of the shaft. The conductive path is capable of being connected to a current source. The medical device can further include one or more contrast agents (such as MRI contrast agents, radiopaque materials, and/or ultrasound visible materials), which can be arranged in a predetermined manner.

Abstract: The invention relates to a general composite compartmental model and a compartmental analysis procedure to extract non-invasively the concentration (Cp) of the imaging agent in plasma (301), in metabolites (304, 504) and in blood elements (303) (like red cells, platelets, plasma protein etc.) from time signal curves measured within a reference tissue region (200). This is made possible by deploying an injection function (SINJ(t)) as input which models the amount of imaging agent administered to the patient as a function of time. The invention allows the presentation of the plasma input function to the medical practitioner without the need for invasively drawing blood samples.

Abstract: Multimodal nanoparticles are nanoparticles containing contrast agents for PAT and one or more of luminescence imaging, x-ray imaging, and/or MRI. The multimodal nanoparticles can have a dielectric core comprising an oxide with a metal coating on the core. The particles can be metal speckled. The multimodal nanoparticles can be used for therapeutic purposes such as ablation of tumors or by neutron capture in addition to use as contrast agents for imaging.

Abstract: Methods for quantitative perfusion analysis for embolotherapy are presented. The method quantitatively measures blood flow changes based on angiographic information. The method may provide potential evaluation of optimal embolization endpoints in vascular vessels. The method may be used in various applications such as transcatheter arterial chemoembolization (TACE), or other medical procedures that affect blow flow within bodily tissues. The method is applicable towards treatment of tumors in liver, kidney, brain, and other organs.

Abstract: A method to visualize, display, analyze and quantify angiography, perfusion, and the change in angiography and perfusion in real time, is provided. This method captures image data sequences from indocyanine green near infra-red fluorescence imaging used in a variety of surgical procedure applications, where angiography and perfusion are critical for intraoperative decisions.

Abstract: Methods and systems are disclosed for determining information about a position of an object within a distribution of materials having different complex conductivities. The method includes: (i) causing current to flow in the distribution; (ii) measuring an electrical signal at each of multiple locations in the distribution of materials in response to the current flow; (iii) providing spatial information about the distribution of materials with respect to a first reference frame, the spatial information indicative of regions of different complex conductivity in the distribution of materials; and (iv) determining the position of the object with respect to the spatial information about the distribution of materials based on measured electrical signals and the spatial information. In certain embodiments, the object is a catheter inserted into a patients heart cavity for cardiac mapping.

Abstract: Apparatus is provided for use with at least one labeled radiopharmaceutical agent, the apparatus including a container (22) containing the at least one labeled radiopharmaceutical agent, and a portable computer-communicatable data carrier (120, 24) associated with the container (22), the data carrier (120, 24) containing imaging protocol information for use with the at least one labeled radiopharmaceutical agent. Other embodiments are also described.

Abstract: Controlled local application of drugs to a certain part of a body of a patient may be of major importance during a cardiac CT scan. By transporting the drugs in containers which prevent an application of the drugs and by rupturing only those containers which are located in the vicinity of the part of the body of a patient to which the drugs have to be applied, a local application of the drugs may be performed. According to an exemplary embodiment of the present invention, the rupturing and therefore the application of the drugs may be triggered by a monitoring algorithm which evaluates changes in the heart beat rate of the patient. Advantageously, the method allows for a local delivery of the drugs on a fine time scale and therefore for a fast control of the heart beat rate during the CT scan.