Abstract: The present invention relates to the field of medical monitoring, and in particular non-contact, video-based monitoring of pulse rate, respiration rate, motion, and oxygen saturation. Systems and methods are described for capturing images of a patient, producing intensity signals from the images, filtering those signals to focus on a physiologic component, and measuring a vital sign from the filtered signals.

Abstract: An endoscopic imaging apparatus comprises at least one light source (1, 2, 3) configured to provide excitation signals to an imaging region via a common transmission path. Each excitation signal has one of a plurality of different colours. A controller (100) is configured to control the at least one light source (1, 2, 3) to provide the excitation signals as a repeating time-interleaved sequence that comprises at least an excitation signal of a first one of the colours and a subsequent excitation signal of a second one of the colours. A monochrome detector (80) is configured, for each of at least some of the excitation signals, to receive at least part of a respective response signal emitted from the imaging region in response to the excitation signal and to generate image data based on the at least part of the response signal.

Abstract: A pulse rate detection device includes: a moving image obtaining device configured to obtain a moving image captured by photographing a body surface of a subject, a pulse rate obtaining device configured to obtain a pulse rate of the subject on the basis of change of a pixel value of the body surface in the moving image, a reliability obtaining device configured to obtain reliability of the obtained pulse rate; and an output device configured to output the obtained pulse rate if the obtained reliability thereof is equal to or greater than predetermined reliable criteria.

Abstract: A semantic segmentation method for aircraft point cloud based on voxelization and three views, including: filtering a collected point cloud followed by centralization to obtain a centralized point cloud; inputting the centralized point cloud into a T-Net rotation matrix network; rotating the centralized point cloud to a front side followed by voxelization to obtain a voxelized point cloud; subjecting the voxelized point cloud to voxel filling to obtain a voxel-filled point cloud; calculating thickness maps of three views of the voxel-filled point cloud, followed by sequentially stitching and inputting to the point cloud semantic segmentation network to train the point cloud semantic segmentation network; inputting the collected point cloud into the trained point cloud semantic segmentation network; and predicting a result semantic segmentation of a 3D point cloud of the aircraft.

Abstract: An optical sensing device includes a device casing and an optical sensor on the device casing. In an embodiment, the optical sensing device further includes an image-capturing device on the device casing. The sensing direction of the optical sensor and the capturing direction of the image-capturing device point in the same direction. The image-capturing device can capture an image of an object to be sensed by the optical sensor. In another embodiment, the optical sensing device further includes a flexible shielding cover on the device casing and enclosing the optical sensor for shielding the optical sensor from external light.

Abstract: A spiking retina microscope comprising microscope optics and a neuromorphic imaging sensor. The microscope optics are configured to direct a magnified image of a specimen onto the neuromorphic imaging sensor. The neuromorphic imaging sensor comprises a plurality of sensor elements that are configured to generate spike signals in response to integrated light from the magnified image reaching a threshold. The spike signals may be processed by a processor unit to generate a result, such as tracking biological particles in a specimen comprising biological material.

Abstract: The disclosed embodiments relate to multimodal imaging system, comprising: a fiber-coupled fluorescence imaging system, which operates based on ultra-violet (UV) excitation light; and a fiber-coupled optical coherence tomography (OCT) imaging system. The multimodal imaging system also includes a fiber optic interface comprising a single optical fiber, which facilitates light delivery to a sample-of-interest and collection of returned optical signals for both the fluorescence imaging system and the OCT imaging system. During operation of the system, the single optical fiber carries both UV light and coherent infrared light through two concentric light-guiding regions, thereby facilitating generation of precisely co-registered optical data from the fluorescence imaging system and the OCT imaging system.

Abstract: An apparatus for a smart gym is described herein. The smart gym includes a platform and at least one camera. The platform comprises at least a weight sensor. The at least one camera is configured to capture movements on the platform. In some cases, an exercise is identified by comparing the joint movement to a known joint movement associated with the exercise.

Abstract: An identification apparatus includes a processor and a memory configured to store a program to be executed by the processor. The processor acquires first image data obtained by capturing of an image of an affected area included in a skin or a mucosa by receiving first reception light. The first reception light is reflection light reflected from the affected area irradiated with first irradiation light including white light. The processor further acquires second image data obtained by capturing of an image of the affected area by receiving second reception light. The second reception light is light including light generated by fluorescent reaction in the affected area irradiated with second irradiation light. The second irradiation light includes light that allows the affected area to show fluorescent reaction when the affected area is irradiated with the light. The processor identifies the affected area based on the first image data and the second image data.

Abstract: Methods for determining lipid composition. The lipid(s) in a composition may include phospholipids. A method may be carried out on an individual cell. A method may compare the Raman spectrum of the portion of a cell with a model Raman spectrum, which does not include the lipid component, where the difference between the Raman spectrum of the portion of the cell and the model Raman spectrum correlates to the lipid composition in the portion of the cell in the portion of the cell). A method may be used to diagnose a disease such as, for example, cancers, including breast cancer, prostate cancer, and via the presence and/or absence of abnormal or damaged cells in an individual.

Abstract: A brain activity estimation device includes a brain activity estimation portion. The brain activity estimation portion includes a blood-circulation-amount calculating unit and an estimation unit. The blood-circulation-amount calculating unit is configured to calculate time-series blood-circulation-amount data on a facial surface of a human based on RGB data of photographed image data on the facial surface acquired in time series. The RGB data is obtained by conducting RGB processing on the photographed image data. The RGB processing includes decomposing the photographed image data into three color components composed of an R component, a G component and a B component. The estimation unit is configured to estimate brain activity of the human based on a plurality of decomposition components obtained by decomposing the blood-circulation-amount data by singular value decomposition, principal component analysis, or independent component analysis.

Abstract: A spectroscopic camera according to the present disclosure includes a spectroscopic section configured by a variable wavelength interference filter that selectively transmits light at a predetermined wavelength and changes the light to transmitted light, a receiving section configured to receive sensitivity information indicating a sensitivity curve in a wavelength region of a predetermined color imaged by an RGB camera, a wavelength-table generating section configured to generate, based on the sensitivity information, a wavelength table indicating a relation between the predetermined wavelength and a transmission time, which is a time for transmitting the transmitted light, an imaging section configured to acquire a spectral image formed by the transmitted light transmitted through the spectroscopic section, and a control section configured to control the spectroscopic section and the imaging section based on the wavelength table.

Abstract: A disease prediction apparatus may include: a spectrometer configured to obtain an optical spectrum of a subject; and a processor configured to predict autofluorescence of the subject based on the optical spectrum by applying the optical spectrum to an autofluorescence prediction model, and predict a risk of developing a cardiovascular disease based on the predicted autofluorescence.

Abstract: Provided is a multispectral imaging device for providing precise tracking and verification. The imaging device may configure a first filter for a sensor, and may determine first spectral properties of a target object based on a first image of the target object generated from visible light passing through the first filter onto the sensor. The imaging device may configure a different second filter for the sensor, and may determine second spectral properties of the target object based on a second image of the target object generated from the non-visible light passing through the second filter onto the sensor. The imaging device may align the second spectral properties of the second image with the first spectral properties of the first image, and may present the first spectral properties with the second spectral properties in a single composite image of the target object.

Abstract: A method for treating cystitis, in particular acute cystitis, comprising administering to a patient in need thereof, an effective amount of a reagent selected from the group consisting of IL-1? inhibitors and MMP inhibitors, or proteins selected from ASC or NLRP-3. Diagnostic methods are also described and claimed.

Abstract: Disclosed is optical observation equipment for identifying the forming process of a malignant tumor, which is provided with a receiving space and a transparent front end. The optical observation equipment comprises: a light-guide fiber, a laser emitter, a focusing device, a white light emitter, an image sensor, a high gain amplifier and an encoding and emitting device, wherein the light-guide fiber extends to the transparent front end from the receiving space; the laser emitter emits laser with a wavelength of 340 nm±20 nm and an energy of 0.3˜0.

Abstract: The present invention relates to systems and methods or wide-field polarized imaging of the skin. Preferred embodiments of the invention provide quantitative characterization of collagen structures in the skin and can be used to monitor skin treatment. A preferred embodiment can comprise a handheld imaging device that generates polarized images at different depths beneath a dermal surface and a data processor to process image data.

Abstract: In one embodiment, a computer-readable non-transitory storage medium embodies software that is operable when executed to, in real time, capture a number of images of a user; identify one or more regions of interest corresponding to one or more superficial arteries of the user. The identification is based on a signal-to-noise ratio of photoplethysmogram (PPG) data obtained from the plurality of images. The software is further operable to measure, based on the PPG data, blood volume pulse (BVP) signals; and based on the measured BVP signals, compute one or more cardiological metrics for the user.

Abstract: A method for capturing a high-quality cardiac plethysmography signal automatically and seamlessly using the video cameras embedded in personal electronic devices, includes a program running in the background that periodically takes a picture of the person using the device, runs face detection and/or recognition algorithm, and upon detection of a face, records a video, and then processes the video using algorithms to assess video quality by extracting video quality parameters. When video quality parameters are above predefined thresholds, the recorded video is processed further to generate a plethysmography signal indicative of cardiac activity. The plethysmography signal may then be processed to deduce cardiac activity. The method maintains a pleasurable user experience with the personal electronic devices.

Abstract: For the purpose of allowing fat to be stably distinguished irrespective of individual differences, so as to prevent damage to nerves that surround a target organ, an image processing device includes: a fat-image-region extracting unit that extracts a fat-image region that indicates a region, in a living-tissue image, where fat exists; a fat-color-component detecting unit that detects a fat-color-component amount that determines the color of fat, from the fat-image region extracted by the fat-image-region extracting unit; and a correction unit that corrects the signal intensity of the fat-image region extracted by the fat-image-region extracting unit on the basis of the fat-color-component amount detected by the fat-color-component detecting unit.

Abstract: A spectral radiometer system, measures incoming light intensity and spectral distribution in different wavelength-bands. An additional data storage device allows recording of the measured data. The inclusive sensor system yields very high sensitivity to incoming light. Furthermore, outstanding linearity of the detector response over several orders of magnitude of incoming light is achieved. Additional benefits are ultra low power consumption and minimum size. The sensor system can be used in remote solar radiation monitoring applications like mobile solar power units as well as in long-term environmental monitoring systems where high precision and low power consumption is a necessity.

Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to Raman imaging devices (e.g., Raman endoscope probes), methods of using Raman agents and Raman imaging devices to image or detect a signal, and the like.

Abstract: An information processing apparatus includes a determination unit configured to determine, as a threshold value to which a signal intensity value corresponding to a shadow region is compared, a value different from a threshold value to which a signal intensity value corresponding to a region other than the shadow region is compared.

Abstract: Systems and methods for integrating and/or registering a shape sensing fiber in or to various instruments are described herein. Registration fixtures and registration techniques for matching the coordinate system of a fiber to the coordinate system of an elongate instrument or other device are provided. Various systems and methods for integrating a shape sensing fiber into an elongate instrument or other device are also described herein.

Abstract: System and method for distinguishing at least one first object from at least one second object in a plurality of digital images is provided. The at least one first object having received at least one molecule comprising genetic information, the at least one second object not having received a molecule comprising genetic information. The at least one molecule is configured to receive one of a plurality of fluorescent compounds in each of a plurality of cycles. The digital images being determined by an optical imaging system during emission of electromagnetic radiation by the fluorescent compounds, wherein the plurality of digital images comprises a plurality of series of images, each image of a series referring to the emission spectrum of a respective fluorescent compound and wherein the series of images is repeatedly taken for each of the plurality of cycles.

Abstract: A multi-site fluorescence recording system provides simultaneous monitoring of cell activity in different brain regions of a freely moving animal. The system includes an electrical rotary joint that couples signals to and from an external data acquisition and control unit connected to a stator of the rotary joint, which releases twisting of the optical fibers connected to the animal. Electrical signals are coupled to one or more fluorescence stimulation/detection units on the rotor of the rotary joint. The fluorescence stimulation/detection units receive one or more connections from optical fibers that connect the stimulation/detection unit(s) to the different brain sites. The rotating stimulation/detection units include spectral filters to separate the excitation light from the fluorescence signal, light sensors (an image sensor or photodiodes) and excitation light sources.

Abstract: Provided is an observation apparatus that observes tissues of an organism. The observation apparatus includes a generator that generates first data obtained by irradiating the tissues with a first infrared light with a first wavelength and second data obtained by irradiating the tissues with a second infrared light with a second wavelength being different from the first infrared light in an optical property value with respect to a water, and a comparison calculator that compares the first data with the second data to generate bodily fluid data that indicates a presence of a bodily fluid on a surface of the tissues.

Abstract: Provided is a sample property detecting apparatus including: a wave source configured to irradiate a wave towards a sample; a detector configured to detect a laser speckle that is generated when the wave is multiple-scattered by the sample, at every time point that is set in advance; and a controller configured to obtain a temporal correlation that is a variation in the detected laser speckle according to time, and to detect properties of the sample in real-time based on the temporal correlation, wherein the detector detects the laser speckle between the sample and the detector or from a region in the detector.

Abstract: Systems and methods for accurately and efficiently diagnosing, assessing, staging, and treating pressure ulcers, as well as preventing reverse staging of pressure ulcers, are disclosed. The system, in one embodiment, ensures that the rationale for the stage assigned to the patient will be in the patients' medical record. The system, in various embodiments, further suggests the pressure ulcer classification and allows the user to choose which classification terms should be used. In various embodiments, the system also allows for the different classification/staging system guidelines to be used, including the National Pressure Ulcer Advisory Panel (NPUAP) guidelines, the European Pressure Ulcer Advisory Panel Guidelines (EPUAP), the Pan Pacific Pressure Injury Alliance, CMS, WHO, and the MDS Guidelines.

Abstract: An electrosurgical device for recognizing tissue by means of spectral analysis of the light generated at an electrode. An acoustic or optical indicator device displays the tissue type permanently or when detecting certain tissue. Indicators, in particular optical indicators, are arranged in the application field of view, so as to support the user in response to making an incision.

Abstract: Systems and methods for tracking and analysis physical activity is disclosed. In some aspects, a provided method includes receiving a time sequence of images captured while with an individual is performing the physical activity, and generating, using the time sequence of images, at least one map indicating a movement of the individual. The method also includes identifying at least one body portion using the at least one map, and computing at least one index associated with the identified body portions to characterize the physical activity of the individual. The method further includes generating a report using the at least one index.

Abstract: A photoelectric type pulse signal measuring method includes, obtaining a main-path light signal transmitted by a photoelectric transmitter and reflected back from a surface of skin having an artery underneath, obtaining at least one auxiliary-path light signal receiving an ambient light signal, and based on the at least one auxiliary-path light signal, adaptively filtering an ambient light interference from the main-path light signal and obtaining an adaptive filtration result; or obtaining at least one auxiliary-path light signal transmitted by the same photoelectric transmitter and reflected back from a surface of skin without any artery underneath, and based on the auxiliary-path light signal, adaptively filtering a motion interference from the main-path light signal; then extracting a pulse signal from the adaptive filtration result. The present invention can simply and effectively eliminate the ambient light interference or motion interference upon photoelectric pulse signal measurement.

Abstract: A spectral radiometer system, measures incoming light intensity and spectral distribution in different wavelength-bands. An additional data storage device allows recording of the measured data. The inclusive sensor system yields very high sensitivity to incoming light. Furthermore, outstanding linearity of the detector response over several orders of magnitude of incoming light is achieved. Additional benefits are ultra low power consumption and minimum size. The sensor system can be used in remote solar radiation monitoring applications like mobile solar power units as well as in long-term environmental monitoring systems where high precision and low power consumption is a necessity.

Abstract: Systems, apparatuses and methods may provide for a light collector to capture an inbound optical signal and a plurality of detectors, wherein each detector is associated with a wavelength detection range that differs from one or more wavelength detection ranges associated with one or more remaining detectors in the plurality of detectors. Additionally, a microelectromechanical system (MEMS) device may include a plurality of mirrored columns, wherein each mirrored column is coated with a material that is associated with a wavelength reflection range that differs from one or more wavelength reflection ranges associated with one or more remaining mirrored columns in the plurality of mirrored columns. In one example, the MEMS device positions the plurality of mirrored columns to route the inbound optical signal to one or more of the plurality of detectors based on an input signal from a user input device.

Abstract: An end stage renal disease (ESRD) monitoring system may include an implantable sensor and a reader device with an optical sensor. The implantable sensor may be configured to detect a group of analytes relevant to ESRD, such as glucose, creatinine, urea, and potassium. The implantable sensor may be implanted into the dermis of an animal, and may exhibit color changes in response to the presence of the target analytes or reaction product(s) thereof. The reader device may be configured to capture an image of the implanted sensor and to determine the concentration of the target analytes based at least in part on the image. The reader device may be a personal electronic device such as a cell phone, PDA, or personal computer.

Abstract: In one aspect, the present invention relates to a process for intra-operatively providing anatomical guidance in endocrine surgery. In one embodiment, the process includes the steps of illuminating tissues in the neck area of a living subject with a beam of light having a predetermined wavelength, obtaining Raman data from light scattered from the illuminated tissues, finding Raman signatures corresponding to thyroid or parathyroid tissues from the obtained Raman data, and identifying the thyroid or parathyroid tissues from the corresponding Raman signatures.

Abstract: A method of assessing tissue health comprises the steps of obtaining depth-resolved spectra of a selected area of in vivo tissue, and assessing the health of the selected area based on the depth-resolved structural information of the scatterers. Obtaining depth-resolved spectra of the selected area comprises directing a sample beam towards the selected area at an angle, and receiving an angle-resolved scattered sample beam. The angle-resolved scattered sample beam is cross-correlated with the reference beam to produce an angle-resolved cross-correlated signal about the selected area, which is spectrally dispersed to yield an angle-resolved, spectrally-resolved cross-correlation profile having depth-resolved information about the selected area. The angle-resolved, spectrally-resolved cross-correlation profile is processed to obtain depth-resolved information about scatterers in the selected area.

Abstract: A data processing device controls the image-recording device to capture a video, turn the video into a time series of luminance values, and analyzes the frequency spectrum of this time series. The device determines whether said series of images depicts a test subject. The device extrapolates the emotional response of a detected test subject to choices displayed on the display device during a time period encompassed by said series of images. The extrapolation of the emotional response measures the subject's time between heart rate events, the associated frequency spectrum, and where said captured video comprises a close-up depiction of a region of the subject's exposed skin.

Abstract: A method for the measurement and analysis of skin fluorescence across multiple subjects. The method includes illuminating each subject with an excitation wavelength, detecting a peak fluorescence level within a corresponding emission wavelength range, determining relative levels of skin glycation for each subject, and evaluating the efficacy of a skin treatment based on the relative levels of skin glycation. The method can include ranking and normalizing the peak fluorescence levels for each subject, and the method is suitable for use in placebo-controlled studies of anti-glycation skin therapies.

Abstract: Provided are methods and systems for concurrent imaging at multiple wavelengths. In one aspect, an imaging device includes at least one objective lens configured to receive light backscattered by an object, a plurality of pixel array photo-sensors, a plurality of bandpass filters covering respective photo-sensors, where each bandpass filter is configured to allow a different respective spectral band to pass through the filter, and a beam steering assembly in optical communication with the at least one objective lens and the photo-sensors. The beam steering assembly directs light received by at least one objective lens from the tissue of a subject to at least one pixel array photo-sensor in the plurality of pixel array photo-sensors.

Abstract: A diagnostic system comprises a spectral image shooting means that shoots a spectral image within a predetermined wavelength range in a body cavity and obtains spectral image data, an image processing means that obtains the spectral image data and calculates an indicator indicating an area having a high possibility of a diseased portion from the spectral image data, and a monitor on which the indicator is displayed, and wherein the image processing means calculates, as the indicator, a ratio between an accumulated value of intensity values of all spectral images in the predetermined wavelength range and an intensity value of spectral images in a particular wavelength band, for each coordinate in the spectral image.

Abstract: In one embodiment, the invention relates to a processor based method for generating positional and other information relating to a stent in the lumen of a vessel using a computer. The method includes the steps of generating an optical coherence image data set in response to an OCT scan of a sample containing at least one stent; and identifying at least one one-dimensional local cue in the image data set relating to the position of the stent.

Abstract: Catheter-based systems for in-vivo targeted light therapy include a first type of catheter configured for photo-activating photosensitive substances in tissue, and a second type of catheter configured for photo-degrading photosensitive substances in tissue. The catheters may be configured to produce light using a variety of light sources, such as light emitting diodes (LEDs) and fiber optics. The light transmission is directed to tissue in such a way that only portions of tissue in a treatment area are exposed to light, depending upon whether the tissue is diseased or healthy.

Abstract: A method of analyzing an OCT image. An OCT image has many differently colored dots. The system detects the number of differently colored dots, quantifies them and performs statistical analyses to determine a likelihood of disease. The different colored dots correspond to different retina cell types and structures.

Abstract: A hyperspectral/multispectral imager comprising a housing is provided. At least one light source is attached to the housing. An objective lens, in an optical communication path comprising originating and terminating ends, is further attached to the housing and causes light to (i) be backscattered by the tissue of a subject at the originating end and then (ii) pass through the objective lens to a beam steering element at the terminating end of the communication path inside the housing. The beam steering element has a plurality of operating modes each of which causes the element to be in optical communication with a different optical detector in a plurality of optical detectors offset from the optical communication path. Each respective detector filter in a plurality of detector filters covers a corresponding optical detector in the plurality of optical detectors thereby filtering light received by the corresponding detector from the beam steering element.

Abstract: Various embodiments of systems, components, modules, routines, and processes for luminescence based spectral measurement are described herein. In one embodiment, a method for measuring a scintillation property of a sample includes directing an ionizing radiation toward the sample, thereby inducing the sample to produce an emission. The method also includes acquiring a spectral luminescence of the produced emission by the sample, the spectral luminescence including a plurality of luminescence intensities at corresponding emission wavelengths or frequencies. The scintillation property of the sample may then be determined based on the acquired spectral luminescence.

Abstract: A raman spectrum measuring method for drug inspection is provided, comprising: measuring raman spectrum of a sample to be inspected to acquire an original raman spectrum curve of the sample; determining whether the original raman spectrum curve has a characterizing portion, and if not, measuring a mixture of the sample and an enhancing agent to acquire an enhanced raman spectrum curve of the sample; and if the original raman spectrum curve of the sample to be inspected has a characterizing portion, comparing the original raman spectrum curve of the sample with data in an original raman spectrum database of a drug to determine whether the sample contains the drug, otherwise, comparing the enhanced raman spectrum curve of the sample with data in an enhanced raman spectrum database of the drug to determine whether the sample to be inspected contains the drug.

Abstract: A method for locating one or more interproximal tooth regions in a digital tooth image. The method can be executed at least in part on data processing hardware. The method includes generating the digital tooth image from a fluorescence image of one or more teeth and a reflectance image of the one or more teeth, so as to combine image data from the fluorescence and reflectance images. The digital tooth image has intensity values for pixels corresponding to the one or more teeth and background. The method identifies one or more tooth regions by processing the digital tooth image and locates the one or more interproximal tooth regions according to the one or more identified tooth regions.

Abstract: An apparatus and method for measuring perfusion in a tissue. The method comprising the steps of recording images of the tissue under laser light, calculating a plurality of contrast images from the plurality of images of the tissue, determining a power spectrum of scattered light from the plurality of contrast images, and determining perfusion from the power spectrum. The apparatus comprises a digital video camera, a laser light source, and a processor arranged to operate the camera to produce a plurality of images with different exposure times, receive the plurality of images from the camera and process the images to determine a power spectrum and determine perfusion from the power spectrum.

Abstract: In part, the invention relates to computer-based methods, devices, and systems suitable for displaying stent malapposition in a 2-D or 3-D image. A threshold malapposition distance can be set as an input in response to which a software component in an imaging pipeline automatically detects stent struts and calculates a malapposition distance from a lumen contour. Projections of stent strut dimensions can be used to compensate for stent imaging artifacts results from imaging probe orientation in the lumen.