Visible Light Radiation Patents (Class 600/476)
  • Patent number: 10254533
    Abstract: In a minimally invasive surgical system, an image capture unit includes a prism assembly and sensor assembly. The prism assembly includes a beam splitter, while the sensor assembly includes coplanar image capture sensors. Each of the coplanar image capture sensors has a common front end optical structure, e.g., the optical structure distal to the image capture unit is the same for each of the sensors. A controller enhances images acquired by the coplanar image capture sensors. The enhanced images may include (a) visible images with enhanced feature definition, in which a particular feature in the scene is emphasized to the operator of minimally invasive surgical system; (b) images having increased image apparent resolution; (c) images having increased dynamic range; (d) images displayed in a way based on a pixel color component vector having three or more color components; and (e) images having extended depth of field.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: April 9, 2019
    Assignee: Intuitive Surgical Operations, Inc.
    Inventor: Ian McDowall
  • Patent number: 10234633
    Abstract: A four-dimensional multiplexing method and four-dimensional multiplexing system are provided for optical networks. The method includes receiving sensor data to be transmitted on an optical network. The method also includes encoding the sensor data into an optical signal employing one or more multiplexing systems. The method additionally includes transmitting the optical signal over the optical network. The method further includes decoding the optical signal into the sensor data employing the one or more multiplexing systems. The method also includes controlling an operation of a processor-based machine responsive to the sensor data.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: March 19, 2019
    Assignee: NEC Corporation
    Inventors: Ivan B. Djordjevic, Shaoliang Zhang, Ting Wang
  • Patent number: 10234445
    Abstract: A system and method that images biological samples and uses chromophores to analyze the imaged samples. The chromophore analysis can be done by itself or in conjunction with fluorophore analysis in High Content Imaging systems. To perform chromophore analysis the biological samples can be labeled with different chromophores and imaged using transmitted light that is at least partially absorbed by the chromophores. To also perform fluorophore analysis the samples can also be labeled with fluorophores that are excited by excitation light. The chromophore analysis and fluorophore analysis can be performed separately or concurrently using a High Content Imaging system. The system provides the expanded capability by illuminating the chromophore-labeled samples with transmitted light of different wavelengths and automatically detecting the images which represent the differential absorption of the colored lights by the sample.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: March 19, 2019
    Assignee: CELLOMICS, INC.
    Inventors: Richik Niloy Ghosh, Dirk John VandenBerg, III, Keith Rao Heffley, Monica Jo Tomaszewski, Jeffrey Robert Haskins
  • Patent number: 10226307
    Abstract: Robotic debridement apparatuses, related systems, and methods of using the same are disclosed herein. The robotic debridement apparatuses are configured to facilitate debridement of tissue from a wound region. For example, the robotic debridement apparatuses can include one or more of at least one debriding tool configured to debride tissue, at least one tissue disposal tool configured to dispose of substances in the wound region, to the wound region. The systems disclosed herein can include a plurality of robotic debridement apparatuses. The systems disclosed herein can include a dressing associated with the plurality of robotic debridement apparatuses. The dressing can be associated with the robotic debridement apparatuses in a manner that facilitates operations of the robotic debridement apparatuses.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: March 12, 2019
    Assignee: ELWHA LLC
    Inventors: Michael H. Baym, Mahalaxmi Gita Bangera, Hon Wah Chin, Roderick A. Hyde, Jordin T. Kare, Nathan P. Myhrvold, Elizabeth A. Sweeney
  • Patent number: 10219703
    Abstract: A method and system for intra-oral imaging using High Dynamic Range (HDR) and highlight removal is presented. The method comprising generating a first High HDR irradiation map of teeth with multiple images captured with different exposures for same intra-oral scene; and removing highlight caused by a specular reflection in a detail-reserved way from the first HDR irradiation map so as to obtain a second HDR irradiation map in which the specular reflection is at least partly suppressed.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: March 5, 2019
    Assignee: Carestream Dental Technology Topco Limited
    Inventors: Yingqian Wu, Wei Wang, Guijian Wang, Victor C. Wong
  • Patent number: 10220529
    Abstract: System and method for improving the shaving experience by providing improved visibility of the skin shaving area. A digital camera is integrated with the electric shaver for close image capturing of shaving area, and displaying it on a display unit. The display unit can be integral part of the electric shaver casing, or housed in a separated device which receives the image via a communication channel. The communication channel can be wireless (using radio, audio or light) or wired, such as dedicated cabling or using powerline communication. A light source is used to better illuminate the shaving area. Video compression and digital image processing techniques are used for providing for improved shaving results. The wired communication medium can simultaneously be used also for carrying power from the electric shaver assembly to the display unit, or from the display unit to the electric shaver.
    Type: Grant
    Filed: July 10, 2018
    Date of Patent: March 5, 2019
    Assignee: May Patents Ltd.
    Inventor: Yehuda Binder
  • Patent number: 10222362
    Abstract: A Raman spectroscopic detection device comprising at least one microfluidic sample channel; at least one excitation waveguide for exciting a Raman signal and at least one collection waveguide for collecting a Raman signal. The output of the excitation waveguide and the input of the collection waveguide are positioned directly in the microfluidic sample channel.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: March 5, 2019
    Inventors: Praveen Cheriyan Ashok, Gajendra Pratap Singh, Kishan Dholakia
  • Patent number: 10215697
    Abstract: A method and apparatus for measuring 3D refractive-index tomograms using a wavefront shaper in ultra-high speed and high precision is provided. The method includes the steps of modifying at least one of an illumination angle and a wavefront pattern of an incident ray through the wavefront shaper and leading the modified incident ray to a sample, measuring a 2D optical field, which passes through the sample, through an interferometry along at least one or more of the incident rays, and obtaining 3D refractive-index tomograms through measured information of the 2D optical field.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: February 26, 2019
    Assignee: TOMOCUBE, INC.
    Inventors: YongKeun Park, Kyoohyun Kim, Seungwoo Shin
  • Patent number: 10201535
    Abstract: The present invention relates to a method for treating skin diseases and skin conditions in a patient in need thereof which comprises of administering a therapeutically effective amount of a pharmaceutical composition comprising a therapeutically effective amount of 7-(1H-imidazol-4-ylmethyl)-5,6,7,8-tetrahydro-quinoline, or its individual enantiomers or the tautomers thereof, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: February 12, 2019
    Assignee: ALLERGAN, INC.
    Inventors: Mohammed I. Dibas, Edward C. Hsia, John E. Donello, Daniel W. Gil
  • Patent number: 10194836
    Abstract: Biometric monitoring devices, including various technologies that may be implemented in such devices, are discussed herein. Additionally, techniques for enhancing GPS speed and distance measurements based on step counts measured by a biometric monitoring device are provided. Such techniques may, in some implementations, involve blending two independently-measured data streams of raw distance traveled—one based on inter-coordinate GPS coordinate distances and one based on step count and stride length—using a Kalman filter to provide an enhanced-accuracy measurement of distance or speed traveled. In some other or additional implementations, distances or speeds calculated based on inter-coordinate GPS coordinate distances may be smoothed with a smoothing constant that is proportional to the variance in measured step count.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: February 5, 2019
    Assignee: Fitbit, Inc.
    Inventors: Subramaniam Venkatraman, Heiko Gernot Albert Panther, Shelten Gee Jao Yuen
  • Patent number: 10194860
    Abstract: A virtual image display system adapted for venipuncture applications is provided. The virtual image display system includes at least one infrared light source, at least one image sensing module, and at least one virtual image display module. The at least one infrared light source is configured to emit at least one infrared light to a tissue having a vein. The at least one image sensing module is configured to receive the infrared light from the tissue so as to sense an image of the vein. The at least one virtual image display module is disposed in front of at least one eye of a user. The at least one virtual image display module includes an image display unit configured to show an image of the vein to the at least one eye of the user.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: February 5, 2019
    Assignee: Industrial Technology Research Institute
    Inventors: Chy-Lin Wang, Kuo-Tung Tiao, Tian-Yuan Chen, Lung-Pin Chung, Chun-Chuan Lin, Jyh-Chern Chen, Chi-Shen Chang, Ching-Chieh Yang
  • Patent number: 10146304
    Abstract: A system and methods for the enhancement of a user's vision using a head-mounted and user-controllable device including a magnification bubble having variable attributes wherein a portion of the scene is magnified within the complete scene, wherein the user is able to modify, in real-time, how the images are processed including the attributes of the magnification bubble.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: December 4, 2018
    Assignee: IrisVision, Inc.
    Inventors: Frank S. Werblin, Robert Massof, Yuval S. Boger
  • Patent number: 10111614
    Abstract: A device for observing a sentinel lymph node (SLN) in a human body. The present invention relates to a device for observing an SLN by detecting near-infrared (NIR) fluorescence caused by a fluorescent material such as indocyanine green (ICG) at the SLN and a method for detecting NIR fluorescence at an SLN. Particularly, in the implementation of a composite image obtained by reproducing a fluorescent material such as ICG and NIR fluorescence emitted by excitation light together with a visible light image, it is possible to detect an SLN with high accuracy through a color contrast method and/or a temporal modulation method using an NIR fluorescence image signal and a visible reflection light image signal.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: October 30, 2018
    Assignee: INTHESMART CO. LTD.
    Inventors: Uk Kang, Ilhyung Shin
  • Patent number: 10107739
    Abstract: Disclosed herein is a system, particularly a microscope system, for confocal Raman-spectroscopic measurements. The system is configured to detect minute sample amounts of microbes in a sample chamber with a lid, wherein the system is configured such that a comparably large working distance between the objective lens and the sample is sustained such that a measurement can be performed through the lid of the sample chamber. This allows for cultivating and measuring the sample in the same container.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: October 23, 2018
    Assignee: UNCHAINED LABS
    Inventors: Karsten Goede, Lothar Holz, Markus Lankers, Oliver K. Valet
  • Patent number: 10101268
    Abstract: A method of measuring a spectral response of a biological sample (1), comprises the steps generation of probe light having a primary spectrum, irradiation of the sample (1) with the probe light, including an interaction of the probe light and the sample (1), and spectrally resolved detection of the probe light having a modified spectrum, which deviates from the primary spectrum as a result of the interaction of the probe light and the sample (1), said modified spectrum being characteristic of the spectral response of the sample (1), wherein the probe light comprises probe light pulses (2) being generated with a fs laser source device (10). Furthermore, a spectroscopic measuring apparatus is described, which is configured for measuring a spectral response of a biological sample (1).
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: October 16, 2018
    Assignees: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V., Ludwig-Maximilians-Universitaet Muenchen
    Inventors: Alexander Apolonskiy, Ioachim Pupeza, Ferenc Krausz, Ernst Fill
  • Patent number: 10088669
    Abstract: An endoscope includes an insertion section in which a rigid distal end portion, a bending section for changing a direction of the rigid distal end portion, and a flexible portion are concatenated and an optical fiber that transmits an optical signal, the optical fiber being inserted through an inside of the insertion section. The rigid distal end portion is provided with an image pickup device, an optical element that converts an electric signal outputted by the image pickup device into the optical signal, a holding member including a through-hole, into which a distal end portion of the optical fiber is inserted, and a wiring board on which the optical element is mounted and to which the holding member is joined. The optical fiber is inserted through a center of the bending section.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: October 2, 2018
    Inventors: Youhei Sakai, Hideharu Miyahara
  • Patent number: 10080623
    Abstract: A visible light projection device includes a detecting unit that detects a first region emitting non-visible light, a projecting unit that performs projection using visible light onto a second region including the detected first region, and a control unit that controls the projecting unit to perform projection with a color selected by an operator. When a first color is selected as a color of visible light projected by the projecting unit onto a region other than the first region, the control unit informs the operator of first options to allow a color of visible light projected onto the first region to be selected from the first options. When a second color different from the first color is selected, the control unit informs the operator of second options to allow a color of visible light projected onto the first region to be selectable from the second options.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: September 25, 2018
    Inventors: Tomoyuki Saito, Etsuro Hatano, Takashi Nitta, Satoru Seo, Hisashi Nishida
  • Patent number: 10055848
    Abstract: The invention relates to a data processing method of determining a transformation for transforming medical image data into a positional reference system, the method being executed by a computer and comprising the following steps: a) acquiring, from a medical imaging apparatus (5), medical image data comprising medical image information describing a two-dimensional image of an anatomical body part (1); b) acquiring medical image selection data comprising medical image selection information describing a selection (4) from the medical image information; c) acquiring imaging apparatus characteristic data comprising imaging apparatus characteristic information describing an imaging characteristic of the medical imaging apparatus (5); d) determining, based on the medical image data, medical image selection data and imaging apparatus characteristic data, selection position data comprising selection position information describing a three-dimensional position of an anatomical structure (2) in the anatomical body part
    Type: Grant
    Filed: January 29, 2013
    Date of Patent: August 21, 2018
    Assignee: Brainlab AG
    Inventors: Juergen Gassner, Uli Mezger, Valentin Elefteriu, Stefan Vilsmeier
  • Patent number: 10052170
    Abstract: System and method for use of mixed and augmented reality Imaging surgical suite and an augmented reality device are provided. A 2D/3D virtual grid having a head-up display with augmented reality is provided. The head-up display can display a 2D radiographic image or 3D volumetric representation or shape model of image, and can further display an augmented reality grid/indicator which can be depicted as a grid, implant, instrument or bone avatar/figure representing shapes, orientations, and positions relative to an anatomical image or model. The augmented reality indicator can be displayed directly in a surgeon's field of view to provide a live, intra-operative situational environment and navigational guidance for the surgeon. The head-up display can show avatar grids/indicators that are outside of the surgeon's field of view within a patient's body.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: August 21, 2018
    Inventors: Edouard Saget, Richard Boddington
  • Patent number: 10045719
    Abstract: In a special mode, an internal body portion is imaged under a first white light beam to obtain a first frame composed of blue, green, and red signals. Sequentially, the body portion is imaged under a second white light beam to obtain a second frame composed of blue, green, and red signals. An oxygen saturation level is calculated from the signals. A special image is produced based on the oxygen saturation level. A displacement between the first and second frames is calculated from the signals. If the displacement is a first allowable value or more and less than a second allowable value, the special image is displayed with a lower chroma on a monitor, as compared with a case where the displacement is less than the first allowable value. If the displacement is the second allowable value or more, the special image is converted into a gray scale image.
    Type: Grant
    Filed: October 23, 2012
    Date of Patent: August 14, 2018
    Assignee: FUJIFILM Corporation
    Inventor: Takaaki Saito
  • Patent number: 10048566
    Abstract: An apparatus and method that reduces laser speckle by using stimulated Raman scattering in an optical fiber. The fiber core diameter and length are selected to achieve a desired output color. An adjustable despeckler is formed by combining two optical fibers in parallel and adjusting the amount of light in each path.
    Type: Grant
    Filed: December 23, 2013
    Date of Patent: August 14, 2018
    Inventors: Barret Lippey, Ian Turner, William Beck, Katherine Snell
  • Patent number: 10045696
    Abstract: Fluorescent markers used to identify a tissue may be imaged in a bright environment by synchronizing the imaging process with rapidly switched ambient lighting so that imaging occurs in phase with a switching off of the ambient lighting. In this way, valuable fluorescent imaging may be performed in an environment that appears to be brightly illuminated, for example in the area of a surgical suite.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: August 14, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Thomas Mackie, Adam Uselmann, Andreas Velten, Surendra Prajapati, Kevin Eliceiri
  • Patent number: 10039934
    Abstract: A method for driving an optical device for optical stimulation. In step (1) upon loading a first image pattern associated with light of a first wavelength into an SLM, the SLM is illuminated with light of the first wavelength for a first time period while the light of the second wavelength is off. In step (2) upon loading a second image pattern associated with light of a second wavelength into the SLM, the SLM is illuminated with light of the second wavelength for a second time period while the light of the first wavelength is off. The steps (1) and (2) are iteratively repeated, in that order, until a predetermined stimulation duration is attained. The first time period and the second time period are both shorter than a response time of a specimen (e.g., neuron(s)) that is being optically stimulated.
    Type: Grant
    Filed: December 29, 2014
    Date of Patent: August 7, 2018
    Inventor: Song Peng
  • Patent number: 10031484
    Abstract: A wearable device includes: a touch screen; an acceleration sensor configured to generate an acceleration signal; an optical sensor using a light source and configured to generate a touch interrupt signal; and a control unit configured to detect a wearing state of the wearable device, the wearing state of the wearable device including a not-wearing state for the wearable device, a wrist wearing state, and a hand gripping state on the basis of the acceleration signal and the touch interrupt signal, and to execute a function corresponding to the wearing state of the wearable device.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: July 24, 2018
    Inventors: Hongjo Shim, Gukchan Lim, Youngho Sohn, Seonghyok Kim, Chohee Kwon, Hyunwoo Kim
  • Patent number: 10022042
    Abstract: Systems and methods for imaging ear tissue include: directing illumination radiation to pass through an intact biological structure and be incident on ear tissue that does not include an exogenous fluorophore, at a plurality of locations, the illumination radiation including a plurality of light pulses each having a temporal duration of 500 femtoseconds or less; for each one of the plurality of locations, using a detector to detect radiation emitted from the location that passes through the intact biological structure; and forming an image of the tissue based on the detected radiation at each of the plurality of locations, where the emitted radiation corresponds to endogenous two-photon fluorescence of the tissue.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: July 17, 2018
    Assignees: Massachusetts Eye & Ear Infirmary, Ecole Polytechnique Federale De Lausanne (EPFL)
    Inventors: Konstantina Stankovic, Demetri Psaltis, Xin Yang, Ye Pu, Chia-Lung Hsieh
  • Patent number: 10022046
    Abstract: A multi-channel optical coherence tomography probe for use in a medical procedure is provided. The probe comprises: a plurality of first optical fibers optically connectable to an OCT light source; a plurality of second optical fibers different from the plurality of first optical fibers; a scanning device comprising: an actuator configured to rotationally move the plurality of second optical fibers between a first position and a second position, relative to the plurality of first optical fibers; and, a mirror configured to, as the plurality of second optical fibers is moving rotationally, convey light from exit faces of the plurality of first optical fibers to entrance faces of the plurality of second optical fibers; and, a housing containing the plurality of second optical fibers.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: July 17, 2018
    Inventors: Fangxin Li, Michael Frank Gunter Wood
  • Patent number: 10012537
    Abstract: A system and method for characterization and/or calibration of performance of a multispectral imaging (MSI) system equipping the MSI system for use with a multitude of different fluorescent specimens while being independent on optical characteristics of a specified specimen and providing an integrated system level test for the MSI system. A system and method are adapted to additionally evaluate and express operational parameters performance of the MSI system in terms of standardized units and/or to determine the acceptable detection range of the MSI system.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: July 3, 2018
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Karl Garsha, Michael Otter
  • Patent number: 9986915
    Abstract: Systems and methods for a short wave infrared (SWIR) otoscope device are provided. The SWIR otoscope device can capture images of a patient's middle ear to aid in diagnosing one of a plurality of maladies. In one embodiment, the SWIR otoscope device can include a SWIR detector, a light source, and a plurality of optics that can enable the SWIR otoscope device to capture images of the middle ear of a patient.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: June 5, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Jessica Carr, Oliver Bruns, Moungi Bawendi, Tulio Valdez
  • Patent number: 9986905
    Abstract: In some example implementations, there is provided a method for predicting retinal degeneration in multiple eye diseases. The method may include receiving three-dimensional data representative of a plurality of layers of a retina of a subject under test; determining, from the received data, oxygen concentration at one or more of the plurality of layers; detecting, based on the determined oxygen concentration, a region of at least one a high oxygen concentration in the retina or a low oxygen concentration in the retina; and comparing the detected region to reference data to determine whether the retina including the detected region suffers from or will suffer from at least one of a retinal disease or a degeneration of the retina. Related apparatus are also disclosed.
    Type: Grant
    Filed: April 23, 2014
    Date of Patent: June 5, 2018
    Assignee: The Schepens Eye Research Institute, Inc.
    Inventors: Kevin McHugh, Magali Saint-Geniez, Leo Kim
  • Patent number: 9971307
    Abstract: An electronic watch with a function of calling for help is provided. The electronic watch includes a main body, a control module, a time display module, a transparent cover, an identifying module and a positioning module. The main body includes a displaying surface. The control module is disposed within the main body. The time display module is installed on the displaying surface and electrically connected with the control module. The transparent cover is aligned with the time display module to cover the displaying surface and connected with the main body. The identifying module is connected with the displaying surface and electrically connected with the control module. The positioning module is disposed within the main body and electrically connected with the control module. Consequently, the efficacy of calling for help and accurately rescuing the user is enhanced.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: May 15, 2018
    Inventor: Kuan-Pao Ting
  • Patent number: 9968244
    Abstract: A fluorescence endoscopy video system includes a multimode light source for producing white light, fluorescence excitation light, or fluorescence excitation light with a reference reflectance light. An endoscope directs light to illuminate a tissue sample and collects reflected light or fluorescence light produced by the tissue. A camera includes a high sensitivity color image sensor having a plurality of pixel elements. Each of the pixel elements has an integrated filter configured to block reflected excitation light from reaching the pixel elements and allow fluorescence and reflectance light to reach the pixel elements. A processor receives image signals from the image sensor, combines image signals from a first group of pixel elements to form a first image formed by fluorescence light, and combines image signals from a second group of pixel elements to form a second image formed by reflectance light. A video monitor simultaneously superimposes the first and second images.
    Type: Grant
    Filed: February 23, 2015
    Date of Patent: May 15, 2018
    Inventors: Richard W. Cline, John J. P. Fengler, Joachim W. Boehm
  • Patent number: 9962563
    Abstract: A medical apparatus (300, 400, 500, 600, 700) comprises a heating system (304) for heating a target zone (324) of a subject (320), wherein the energy density in a predefined volume is modeled (338) using a thermal model and a processor (330) for controlling (340) the heating system (304).
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: May 8, 2018
    Inventors: Julia Kristina Enholm, Kirsi Ilona Nurmilaukas, Max Köhler
  • Patent number: 9962072
    Abstract: In general, certain embodiments of the present disclosure provide methods and systems for analyzing eye and contact lens condition. According to various embodiments, a method is provided comprising receiving an image of an eye. The method further comprises extracting condition information of the eye and receiving diagnosis information from a database. The method further comprises comparing the condition information with the diagnosis information and providing an analysis of the eye. In various embodiments, the eye may include a contact lens on the surface of the eye and the condition information may include a condition of the contact lens. In some embodiments, the analysis may include an estimated suggested time to remove the contact lens. In other embodiments, the analysis may include an estimated expiration of the contact lens. In some embodiments, the database may comprise both local storage and global databases access through a global network.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: May 8, 2018
    Inventor: Anantha Pradeep
  • Patent number: 9957392
    Abstract: Disclosed is a near-infrared fluorescent imaging agent comprising an indocyanine-based fluorescent dye and a liposome. The near-infrared fluorescent imaging agent of the present invention demonstrates high fluorescence intensity and a long anchoring time in sentinel lymph nodes, thereby making it useful for detecting sentinel lymph nodes in sentinel lymph node navigation surgery. Also disclosed is an indocyanine green derivative that is particularly suitable for use in the near-infrared fluorescent imaging agent of the present invention.
    Type: Grant
    Filed: January 29, 2016
    Date of Patent: May 1, 2018
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Hideki Hayashi, Masanori Fujinami, Taro Toyota, Yutaka Tamura, Akira Aoki, Yutaka Muraki, Kazuki Onoue
  • Patent number: 9931072
    Abstract: Determining an optical property of a sample having an illumination of a surface of the sample with the aid of a light beam, so as to form, on the surface of the said sample, an elementary illumination zone, corresponding to the part of the said surface illuminated by the said sample. A detection of N optical signals, backscattered by the sample, each optical signal emanating from the surface of the sample at a distance, termed the backscattering distance, from the said elementary illumination zone, N being an integer greater than or equal to 1, so as to form as many detected signals. A determination of at least one optical property of the sample, by comparison between: a function of each signal thus detected and a plurality of estimations of the said function each estimation being carried out by considering a predetermined value of the said optical property, characterized in that during the said detection step, at least one backscattering distance is less than 200 pm.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: April 3, 2018
    Assignee: Commissariat a l'energie atomique et aux energies alternatives
    Inventors: Blandine Roig, Anne Koenig, Jean-Marc Dinten, Francois Perraut
  • Patent number: 9925113
    Abstract: The disclosed embodiments provide skin stimulating devices and methods that address the aging effects of skin at a protein level. Particularly, cyclical mechanical strain is used to regulate specific proteins within the skin, so as to produce specific effects. As a non-limiting example, the disclosed embodiments can be used to increase the production of certain proteins (e.g., hyaluronan synthase 3 (HAS3); fibronectin; tropoelastin; procoll1; integrin, etc.) in the skin, which results in anti-aging effects by increasing epidermal cohesion.
    Type: Grant
    Filed: December 31, 2014
    Date of Patent: March 27, 2018
    Assignee: L'Oreal
    Inventors: Elisa Caberlotto, Zane Bowman Allen Miller, Laetitia Ruiz, Aaron David Poole, Gerald Keith Brewer
  • Patent number: 9907472
    Abstract: A disease diagnosis and skin age measurement apparatus includes: a first light collection unit; a second light collection unit; a spectrometer configured to measure a spectrum of the light which is collected by the second light collection unit; a spectrum data comparison unit for disease diagnosis configured to compare the spectrum measured by the spectrometer and reference spectrum data for disease diagnosis; a CCD; an image data comparison unit configured to compare the digital image converted by the CCD and a reference image; a disease diagnosis unit configured to determine whether there is a disease in the body tissue; and/or a spectrum data comparison unit for skin age measurement configured to measure skin age by comparing a spectrum measured by the spectrometer and reference spectrum data for skin age measurement, wherein the light projected onto the body tissue is collimate light.
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: March 6, 2018
    Assignee: SPECLIPSE, INC.
    Inventors: Sung Hyun Pyun, Wanki Min
  • Patent number: 9891105
    Abstract: A microspectroscope includes: a light source; a plurality of light projecting optical fibers that receive light from the light source; a spectroscope; a plurality of light receiving optical fibers for guiding received light to the spectroscope; and a confocal optical system for causing each of a plurality of beams from the plurality of light projecting optical fibers to be condensed and irradiated onto a sample, and forming images of a plurality of beams from a plurality of condensing points on the sample, respectively on the plurality of light receiving optical fibers.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: February 13, 2018
    Assignee: Otsuka Electronics Co., Ltd.
    Inventor: Hisashi Shiraiwa
  • Patent number: 9883804
    Abstract: Method, and the associated device, for examining a biological tissue, in particular dental tissue or tooth enamel of one or several teeth, the method including the steps of taking into account at least the fluorescence of the tissue detected in a first wavelength range and the fluorescence of the tissue detected in a second wavelength range. The device can be a surgery microscope with one or several filters. The filters can be swiveled into or out the Illumination beam path or the optical path of the light source of the device.
    Type: Grant
    Filed: February 6, 2013
    Date of Patent: February 6, 2018
    Inventor: Marco Wilzbach
  • Patent number: 9883798
    Abstract: A multimode fundus camera enables three-dimensional and/or spectral/polarization imaging of the interior of the eye to assist in improved diagnosis.
    Type: Grant
    Filed: November 14, 2014
    Date of Patent: February 6, 2018
    Assignee: Ricoh Company, Ltd.
    Inventors: Noah Bedard, Lingfei Meng, Vipin Namboodiri, Krishna Prasad Agara Venkatesha Rao, Kathrin Berkner
  • Patent number: 9885613
    Abstract: A probe including reflector is disclosed to measure the velocity distribution of a moving surface along many lines of sight. Laser light, directed to the surface by the probe and then reflected back from the surface, is Doppler shifted by the moving surface, collected into probe, and then directed to detection equipment through optic fibers. The received light is mixed with reference laser light and using photonic Doppler velocimetry, a continuous time record of the surface movement is obtained. An array of single-mode optical fibers provides an optic signal to one or more lens groups and a reflector, such as a parabolic reflector having a mirrored interior surface.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: February 6, 2018
    Assignee: National Security Technologies, LLC
    Inventor: Daniel K. Frayer
  • Patent number: 9877647
    Abstract: Methods for spectroscopic analysis of biological tissues to classify an individual as diabetic or non-diabetic, or to determine the probability, progression or level of a disease or medical condition in an individual.
    Type: Grant
    Filed: November 7, 2011
    Date of Patent: January 30, 2018
    Assignee: Sinocare Meditech, Inc.
    Inventors: Keith D. Ignotz, Dale A. Rorabaugh, Neil M. Davis, Vincent F. Brancaccio, Paul Williams, Craig H. Misrach
  • Patent number: 9880531
    Abstract: The invention relates to a method and to an apparatus that enables the ambience of e.g. hospital rooms to adapt according the scheduled or non-scheduled activities throughout the day. The ambience generated by lights, sound devices, image, movie displays and other devices is controlled by an ambience controller (100) in dependence of day phases defined by a patient's day schedule or in dependence of other non-scheduled phases which may have been initiated in dependence of a trigger signal (215, 216) generated in response to activities such as the entering of a caterer.
    Type: Grant
    Filed: October 2, 2012
    Date of Patent: January 30, 2018
    Assignee: Koninklijke Philips N.V.
    Inventors: Bartel Marinue Van De Sluis, Roel Peter Geert Cuppen, Ingrid Christina Maria Flinsenberg, Evert Jan Van Loenen
  • Patent number: 9869633
    Abstract: Spectrally analyzing an unknown sample (10A) for the existence of a characteristic includes (i) analyzing a first known sample (10C) having the characteristic and a second known sample (10D) not having the characteristic to identify less than fifty diagnostic spectral features, each diagnostic spectral feature being present at a different diagnostic wavelength in a mid-infrared spectral region; (ii) directing a plurality of interrogation beams (16) at the unknown sample (10A), each of the interrogation beams (16) having a different interrogation wavelength, and each interrogation wavelength corresponding to a different one of the diagnostic wavelengths; (iii) acquiring a plurality of separate output images (245) of the unknown sample (10A), wherein each of the output images (245) is acquired while the unknown sample is illuminated by a different one of the interrogation beams (16); and (iv) analyzing less than fifty output images (245) with a control system (28) to determine whether the characteristic is pres
    Type: Grant
    Filed: March 7, 2017
    Date of Patent: January 16, 2018
    Inventors: Benjamin Bird, Miles James Weida, Jeremy Rowlette
  • Patent number: 9861285
    Abstract: A handheld skin monitoring or measuring device includes a camera having a camera optical axis; and a structured light arrangement configured to project three or more laser fan beams such that the laser fan beams cross at a crossing point in front of the camera.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: January 9, 2018
    Assignee: ARANZ Healthcare Limited
    Inventors: William Richard Fright, Brent Stephen Robinson, Shane Robert Goodwin, Bruce Clinton McCallum, Philip John Barclay
  • Patent number: 9839699
    Abstract: The present subject matter relates to a non-invasive optical imaging method for monitoring early pathological events specific to Alzheimer's disease (AD), such as the development, amount and location of amyloid plaques. The ability to monitor such events provides a basis for, among other things, AD diagnosis, prognosis and assessment of potential therapies. In addition, the present subject matter introduces novel methods for treating AD and retinal ailments associated with AD. A?-plaque detection in living brains is extremely limited, especially at high resolution; therefore the present invention is based on studies focusing on the eyes as an alternative to brain-derived tissue that can be imaged directly, repetitively and non-invasively.
    Type: Grant
    Filed: September 18, 2009
    Date of Patent: December 12, 2017
    Inventors: Yosef Koronyo, Maya Koronyo, Keith L. Black, Michal Schwartz, Daniel L. Farkas
  • Patent number: 9820685
    Abstract: The invention concerns a measurement device to capture at least one vital parameter of a person in a motor vehicle with a steering wheel. The measurement device includes a finger sensor device with an optical sensor device, where the finger sensor device is attached to the steering wheel in the transition zone between a steering wheel spoke and the hub of the steering wheel.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: November 21, 2017
    Assignee: ZF Friedrichshafen AG
    Inventors: Ludger Rake, Andreas Giefer, Joerg Meyer
  • Patent number: 9820636
    Abstract: The attenuation and other optical properties of a medium are exploited to measure a thickness of the medium between a sensor and a target surface. Disclosed herein are various mediums, arrangements of hardware, and processing techniques that can be used to capture these thickness measurements and obtain three-dimensional images of the target surface in a variety of imaging contexts. This includes general techniques for imaging interior/concave surfaces as well as exterior/convex surfaces, as well as specific adaptations of these techniques to imaging ear canals, human dentition, and so forth.
    Type: Grant
    Filed: May 31, 2017
    Date of Patent: November 21, 2017
    Assignee: Massachusetts Institute of Technology
    Inventors: Douglas P. Hart, Federico Frigerio, Davide M. Marini
  • Patent number: 9814906
    Abstract: Disclosed is a system and method for treatment of skin disorders. More particularly, the disclosed invention is directed toward the use of multiple light sources for treating skin with or without the use of a topical compositions or photomodulation enhancing agents. Dual light emitting diodes may, for example, be used at relatively low power (less than about 10 J/cm2) to photomodulate skin or living tissue to reduce wrinkles, fine lines, acne, acne bacteria, and other skin disorders.
    Type: Grant
    Filed: April 22, 2015
    Date of Patent: November 14, 2017
    Assignee: L'OREAL
    Inventor: David H. McDaniel
  • Patent number: 9801525
    Abstract: A method for assembling a cover glass in an endoscope and an endoscope with a cover glass. To assemble a cover glass in an endoscope, an uncoated cover glass is soldered into an intermediate ring, the cover glass soldered into the intermediate ring is provided with a coating, and the intermediate ring provided with the coated cover glass is joined into a sheath of the optical system of the endoscope.
    Type: Grant
    Filed: November 8, 2011
    Date of Patent: October 31, 2017
    Assignee: Karl Storz GmbH & Co. KG
    Inventors: Peter Eisenkolb, Stefan Heseler, Martin Lehmann