Abstract: The present invention has an object to measure lymphatic pressure with more safety and ease at lower cost. To achieve this, a lymphatic pressure-measuring system 1 includes: a manchette 11 fitted on a vital observation portion; a measurement unit 13 that measures and outputs pressure of the manchette 11; an infrared camera 21 that detects fluorescence emitted from fluorescent dye previously injected into a lymph vessel in the vital observation portion; and an image processing device 22 that generates and displays an image showing a position of the fluorescent dye in the lymph vessel based on a detection result of the infrared camera 21. The infrared camera 21 repeats the detection while the pressure of the manchette 11 decreases from first pressure to block a lymph flow in the vital observation portion to second pressure at restart of the lymph flow. The measurement unit 13 repeats the measurement during the period.

Abstract: Non-invasive apparatus and method for determining and monitoring glucose concentrations in human subjects. Glucose level is estimated through the effect of glucose on biological cells with glucose dependencies, e.g., red blood cells. The invention is based on the interaction of such cells with oscillating electric field gradients. The response of biological cells depends on factors including shape, size, and electrical charge distribution. The field gradient causes the cells to undergo characteristic motion which is detected by light beam scattering. The autocorrelation of the scattered light is computed, and the Fourier transform (FT) is performed to produce a characteristic velocity spectrum in which the peaks are characteristic of the cell “bio-electrical” states. The glucose level is estimated through measurements of changes of FT with changes in glucose levels after calibration with standard glucose methods.

Abstract: This invention is a wearable device to measure a person's consumption of selected types of food, ingredients, or nutrients comprising: a housing that is configured to be worn on the person's wrist, arm, hand, or finger; a spectroscopy sensor that collects data concerning light energy reflected from the person's body and/or absorbed by the person's body, wherein this data is used to measure the person's consumption of selected types of food, ingredients, or nutrients; a data processing unit; and a power source. The selected types of food, ingredients, or nutrients can be selected from the group consisting of: food that is high in simple carbohydrates; food that is high in simple sugars; food that is high in saturated or trans fat; fried food; food that is high in Low Density Lipoprotein (LDL); and food that is high in sodium.

Abstract: The present invention in one aspect relates to a method for surgical margin evaluation of tissues during breast conserving therapy at a surgical site of interest. In one embodiment, the method comprises the steps of acquiring a plurality of spatially offset Raman spectra from the surgical site of interest, identifying tissue signatures from the plurality of spatially offset Raman spectra, and determining surgical margins of the surgical site from the identified tissue signatures.

Abstract: Various aspects of the instant disclosure are directed to imaging tissue. As may be implemented in accordance with one or more embodiments, aspects of the present disclosure are directed to apparatuses and methods involving the following. A light source includes an array of light emitters that illuminate a tissue region of a heart wall with light at different wavelength ranges. A light collector collects multispectral images including respective images collected at each of the different wavelength ranges at which the tissue region is illuminated. A catheter positions the light source and light collector proximate the tissue region of the heart wall for respectively illuminating the tissue region and collecting the multispectral images. A display circuit collects and displays one or more images depicting a condition of the health of heart wall tissue, based on the respective images collected at the different ones of the wavelength ranges.

Abstract: A wearable physiological sensing device with optical pathways is described. The wearable physiological sensing device may include at least one light source; a first light pipe coupled with the at least one light source, the first light pipe at least partially circumscribing an extremity of a patient, and including at least one aperture for radiating light from the light source into the extremity. The wearable physiological sensing device may also include a second light pipe including at least one aperture for receiving the light radiated through the extremity, the second light pipe at least partially circumscribing the extremity of the patient, and an optical receiver coupled with the second light pipe configured to receive the light and output one or more signals representative of the received light.

Abstract: There is provided a method for detecting interproximal tooth defects such as caries by injecting light at one or more wavelengths into a tooth and detecting reflected/diffracted light or emitted fluorescence. The detected light intensity is characteristic of a healthy or diseased tooth in the interproximal area.

Abstract: An OCI medical device includes a coherent light source, a light sensor, a first processing unit adapted to calculate OCI Data from the light sensor, a control unit which allows taking or loading of at least one Reference OCI Value, a second processing unit adapted to calculate the Intra-Individual Relative Assessment of the OCI Data of an Imaging Zone and the at least one OCI Reference Value, and display means adapted to show at least one Relative OCI Value. Uses and a method for assessing the blood flow of a body region use OCI imaging and include an Intra-Individual Relative Assessment between OCI Data of the Imaging Zone and at least one Reference OCI Value.

Abstract: The invention generally relates to methods for assessing risk of bone fracture. In certain embodiments, methods of the invention involve a) conducting an assay to determine a characteristic of keratinized tissue obtained from a mammal, b) analyzing at least one bone-fracture risk factor associated with the mammal, and c) correlating results from steps (a) and (b), thereby assessing the risk of bone fracture of a bone of the mammal.

Abstract: Disclosed herein are systems and methods for revascularization assessment. The methods can in some cases include one or more of the steps of measuring blood perfusion as a function of time to obtain time series data, mathematically transforming the time series data into a power spectrum, calculating at least one parameter of the power spectrum within a specific frequency range, and using the at least one calculated parameter as a discriminator for the first population and the second population.

Abstract: Systems and methods for imaging are presented. The method includes producing excitation light configured to induce fluorescence in an imaging agent that selectively binds to a target species in a region of interest (ROI) of a subject that also includes a background species. A first and a second spectral region are selected such that a determined difference between fluorescence corresponding to the target and the background species in the first spectral region differs from a corresponding difference in the second spectral region. First and second fluorescence images are generated from the fluorescence corresponding to the first and second spectral regions. Additionally, a fluorescence ratio for the background species in the first and second fluorescence image is determined. The first fluorescence image is then multiplied or divided with the determined ratio to generate an intermediate image that is subtracted from the second fluorescent image to reconstruct a background-subtracted image.

Abstract: Disclosed herein is a method for obtaining a value of at least one vasodilation parameter representing the cutaneous local thermal hyperemia response of a subject. The temperature of a sampling site is raised from a first temperature to a second temperature and maintained for an initial heating period, and an initial maximum red blood cell flux (RBCF) of the sampling site and a mean arterial pressure of the subject is obtained. An initial maximum cutaneous vascular conductance (CVC1,max) is calculated by dividing the initial maximum RBCF by the mean arterial pressure. The CVC1, max or at least one other parameter derived therefrom is used as the vasodilation parameter.

Abstract: What is disclosed is a system and method for estimating minute ventilation by analyzing distortions in reflections of structured illumination patterns captured in a video of a thoracic region of a subject of interest being monitored for respiratory function. Measurement readings can be acquired in a few seconds under a diverse set of lighting conditions and provide a non-contact approach to patient respiratory function that is particularly useful for infant care in an intensive care unit (ICU), sleep studies, and can aid in the early detection of sudden deterioration of physiological conditions due to detectable changes in chest volume. The systems and methods disclosed herein provide an effective tool for non-contact minute ventilation estimation and respiratory function analysis.

Abstract: This invention relates generally to an index map comprising both pressure and perfusion information from a diabetic patient foot for the purpose of treatment. The index map may also be a map of perfusion and/or metabolism of the tissue (reflecting oxygen delivery and oxygen extraction), obtained by thermal imaging, hyperspectral imaging, or duplex ultrasound, MRA, CT or laser Doppler imaging. This information aids treatment in prevention of diabetic foot ulceration and amputation and in treatment of tissue compromise to prevent tissue loss in other body regions.

Abstract: The present invention relates generally to a methodology of determining the concentration of the types of melanin, either eumelanin or pheomelanin, in the skin wherein the process for such determination is non-invasive and based on digital signal and image analysis of hyperspectral sensing and multi-spectral data.

Abstract: A physiological information measuring apparatus includes a first detection unit, having a first light emitting unit and a first light receiving unit, separated from one another by a first distance. A second detection unit of the physiological information measuring apparatus has a second light emitting unit and a second light receiving unit, separated from one another by a second, different distance. Alternatively, the second detection unit shares the first light emitting unit with the first detection unit and has a second light receiving unit. Alternatively, the second detection unit shares the first light receiving unit with the first detection unit and has a second light emitting unit. A measuring unit of the physiological information measuring apparatus measures the physiological information of a user based on light received by the light receiving unit or light receiving units.

Abstract: A self-diagnostic method for momentarily generating a jaundice index, clinically equivalent to the serum bilirubin level, for newborns including Step S1: obtaining a newborn's image of face based on color markers; Step S2: color correction of the image based on the color markers; Step S3: calculating jaundice index based on color information of pixels of the facial image, excluding undesired interfering. The method can be executed by an APP (Application) product.

Abstract: A hyperspectral/multispectral imager comprising a housing is provided. At least one light source is attached to the housing. An objective lens, in an optical communication path comprising originating and terminating ends, is further attached to the housing and causes light to (i) be backscattered by the tissue of a subject at the originating end and then (ii) pass through the objective lens to a beam steering element at the terminating end of the communication path inside the housing. The beam steering element has a plurality of operating modes each of which causes the element to be in optical communication with a different optical detector in a plurality of optical detectors offset from the optical communication path. Each respective detector filter in a plurality of detector filters covers a corresponding optical detector in the plurality of optical detectors thereby filtering light received by the corresponding detector from the beam steering element.

Abstract: A method of assessing tissue health comprises the steps of obtaining depth-resolved spectra of a selected area of in vivo tissue, and assessing the health of the selected area based on the depth-resolved structural information of the scatterers. Obtaining depth-resolved spectra of the selected area comprises directing a sample beam towards the selected area at an angle, and receiving an angle-resolved scattered sample beam. The angle-resolved scattered sample beam is cross-correlated with the reference beam to produce an angle-resolved cross-correlated signal about the selected area, which is spectrally dispersed to yield an angle-resolved, spectrally-resolved cross-correlation profile having depth-resolved information about the selected area. The angle-resolved, spectrally-resolved cross-correlation profile is processed to obtain depth-resolved information about scatterers in the selected area.

Abstract: The present invention comprises methods and systems/devices for non-invasively measuring birefringent tissues (e.g. collagen) and changes during treatment of tissue, e.g., denaturation by the application of RF energy, through linear dichroism, circular dichroism, or birefringence. The invention optionally uses polarization sensitive optical measurements to discriminate between denaturation of unidirectionally oriented strands of collagen, such as a ligament or tendon, and denaturation of planar collagen surfaces, such as the dermal layer of the skin or collagen in joint capsules.

Abstract: An optical measurement device includes: a measurement light source unit that emits measurement light; measurement probe including an illumination fiber configured to radiate the measurement light to a living tissue, and a light-receiving fiber configured to receive return light of the measurement light reflected and/or scattered from the living tissue; a detection unit that detects the return light; an illumination control unit that causes the measurement light source unit to execute alternately emission and stoppage of the measurement light during the measurement and to emit the measurement light such that the emission time is longer than the stoppage time; and a computation unit that removes, from an intensity of return light of the measurement light detected by the detection unit, a detected intensity of return light of the observation light radiated by an endoscope and reflected from the living tissue.

Abstract: An endoscope 100 includes a first light source 45 that emits white illumination light, a second light source 47 that emits narrow-band light and an imaging section that has an imaging device 21 having plural detection pixels and images a region to be observed. The imaging section is caused to output a captured image signal including both a return light component of the white illumination light from the region to be observed by and a return light component of the narrow-band light the white illumination light. From the captured image signal, the return light component of the narrow-band light is selectively extracted, and a brightness level of the extracted return light component of the narrow-band light is changed by changing a light amount of light emitted from the second light source 47.

Abstract: A disposable tubular end cap for a dermoscope for examining the skin of an animal. The end cap has one end for receiving light from and transmitting light to the dermoscope, a removable calibration target disposed at the other end having optical characteristics similar to a standard skin type, and an identifier disposed on the end cap. The identifier uniquely identifies the end cap and associates it with both data regarding light emitted from the skin of an animal and calibration data derived from the calibration target. Animal tissue may be examined to identify lesions using a plurality of wavelengths and a plurality of polarizations.

Abstract: In a system and a method for examining an object containing a fluid liquid, the object is illuminated with measuring light and images are temporarily shortly subsequently recorded. The images are evaluated per pixel to determine perfusion data from a high frequency portion above 1 kHz and to determine further information about properties of the object from a low frequency portion below 100 Hz, such as a degree of oxygenation of hemoglobin, a concentration of hemoglobin or a concentration of ICG. This information determined by evaluation is displayed in a form of an image in superposition with a white light image of the object.

Abstract: In one arrangement, a smartphone camera gathers skin imagery while controlled spectral illumination is emitted from the smartphone display. In a particular embodiment, differently colored bands move across a darkened screen to illuminate the skin from different angles as plural images are being captured. The collection of imagery from different viewing angles, with different spectral illumination, and different illumination angles, can provide imagery (including composite imagery) useful in manual or automated dermoscopic analysis. A great variety of other features and arrangements are also detailed.

Abstract: A camera mounted in a motor vehicle cabin monitors an upper body and/or face of a vehicle occupant. A computer unit applies pattern recognition methods to compare an image from the camera with reference data stored in a database, and to determine based on the comparison that the occupant is experiencing neck discomfort. The neck discomfort determination is made based on the comparison indicating a change in occupant posture, a change in occupant facial expression, and/or a relaxation movement of the upper body and/or of a head of the occupant. If neck discomfort is detected, warm air and/or infrared light is directed toward the affected neck area to alleviate the discomfort.

Abstract: A system, for use with a cannula insertable into human or animal tissue, for measuring relative motion during a surgical procedure includes a probe having a probe tip insertable into the cannula, and means for determining relative motion between the cannula and the probe tip.

Abstract: According to one embodiment, an apparatus for detecting obstructions in biological vessels includes a cylindrical hollow stent with an expandable body portion having an outer surface configured to engage the inner surface of the lumen of the vessel to urge the vessel against collapse, and an imaging system operatively coupled with stent. The imaging system includes a first power source, a light generating element, a light sensor generating a first signal representative of light received by the sensor element from the light generating elements, and a processor unit receiving the first signal and processing the first signal in accordance with image processing logic stored in a memory of the processor unit to generate an image signal representative of as image of associated target material such as plaque obstructing the flow. The imaging system and stent may be formed on opposite sides of a flexible organic substrate.

Abstract: An optical imaging diagnostic apparatus including: a designating unit for designating a predetermined circumferential-direction position at the circumference of the transmitting and receiving unit on the cross-sectional image displayed; an extraction unit for extracting, within the plurality of line data used for the generation of the cross-sectional image, line data corresponding to circumferential-direction position designated in the designating unit from the storage unit; a calculation unit for calculating attenuation rate in a predetermined region in a radial direction of a body lumen with respect to the extracted line data; and a display unit for displaying the calculated attenuation rate.

Abstract: The present disclosure provides systems and methods for imaging and display of subsurface features of a region of interest such as a portion of a body of a patient. A first imaging portion of the system is used to cause an interaction of an imaging beam with an underlying feature of a region of interest. A retro-reflected or returned portion of said imaging beam is detected by a detector which then provides an output to control a display portion of the system for displaying an image corresponding to that which was detected. The system can be used for guiding or assisting clinical or industrial operations or for diagnosis of medical conditions and other uses within medicine, industry and others.

Abstract: There is provided a measuring apparatus, including a light receiving element, provided at a position facing a measurement object region on which is placed a measurement object, which forms an image with light from the measurement object region, light emitting elements, arranged surrounding the light receiving element, which emit light for measuring the measurement object, and reflective optical elements, provided above the light emitting elements, which guide, to the measurement object region, emission light radiated from the light emitting elements. A light receiving surface of the light receiving element and light emission surfaces of the light emitting elements are positioned mutually on a same plane. The emission light radiated from the light emitting elements is reflected by the reflective optical elements, and center lines of the emission light radiated from each of the light emitting elements pass through an approximate center of the measurement object region.

Abstract: A device for applying a sensor to a measurement site on a patient's skin has a wall arrangement defining an applicator volume above the patient's skin The wall arrangement has a patient's side and a sensor side. At least one gas-permeable membrane separates the applicator volume into a first volume directed to the measuring site at the patient's side of the wall arrangement and a second volume separated from the patient's skin and directed to the sensor side of the wall arrangement.

Abstract: Technologies generally applicable to detecting skin conditions are disclosed. A computer graphics scanning apparatus may be configured to capture skin image data, and use the captured skin image data to calculate a subsurface transfer function for the skin, which may identify subsurface properties of the skin. The identified subsurface properties may be correlated to one or more skin conditions for medical and/or cosmetic treatment diagnosis.

Abstract: A device for determining a vital sign of a subject comprises an interface for receiving a data stream derived from detected electromagnetic radiation reflected from a region of interest including a skin area of the subject, said data stream comprising a data signal per skin pixel area of one or more skin pixels for a plurality of skin pixel areas of said region of interest, a data signal representing the detected electromagnetic radiation reflected from the respective skin pixel area over time. An analyzer is provided for analyzing spatial and/or optical properties of one or more data signals in one or more wavelength ranges. A processor is provided for determining a vital sign information signal of the subject based on the data signals of skin pixel areas within the skin area, and a post-processor is provided for determining the desired vital sign from said vital sign information signal.

Abstract: A medical observation system, which includes a medical probe that observes a subject by scanning on the subject with laser light; a laser source that supplies the laser light to the medical probe; a judgment unit that judges whether the medical probe is in a predetermined state; and a control unit that controls an amount of laser light emitted from the laser source based on a judgment result by the judgment unit.

Abstract: Systems and methods that facilitate analysis of superficial tissue based at least in part on a depth-selective fiber optic probe are discussed herein. The depth-selective fiber optic probe can include an illumination fiber for providing light to the superficial tissue, a collection fiber for collected reflected light, a ball lens that couples the fibers, and a protective overtube that houses the ball lens and fibers. The distances between the ball lens and fibers and between the fibers can be optimized based on several factors, such as by minimizing the illumination spot size, maximizing the overlap between the illumination and collection spots, and based on the angle between the illumination and collection beams.

Abstract: A medical device comprises a device adapted to perform a medical procedure; a biometric information sensing device adapted to sense biometric information of a user; a controller adapted to retrieve stored biometric registration information of a user from a storage device in communication with the controller, to determine an identity of the user by comparing the stored biometric registration information and the sensed biometric information, and to prevent performance of the medical procedure if the sensed biometric information does not correspond to the stored biometric registration information.

Abstract: A medical apparatus includes a storing section in which information concerning a drug movement in a living body is stored for each of types of a plurality of fluorescent drugs, an arithmetic processing section that acquires, based on the information stored in the storing section, information concerning a target region to which a fluorescent drug is administered, information concerning a method of administering the fluorescent drug to the target region, and information indicating start of administration of the fluorescent drug, information concerning diagnosis start timing, an image pickup section, a position information acquiring section that acquires position information of the image pickup section, and a light source control section that stops, at least from the administration start timing to the diagnosis start timing, irradiation of excitation light and irradiates the excitation light based on the diagnosis start timing and the position information.

Abstract: An apparatus for measuring ganglion cells may include: a light generation unit configured to irradiate a first light signal polarized in a first direction and a second light signal polarized in a second direction perpendicular to the first direction to a subject; a reflected light processing unit configured to generate an amplification signal corresponding to an image of the subject using a first reflection signal, which is the first light signal reflected from the subject, and a second reflection signal, which is the second light signal reflected from the subject; and an image processing unit configured to measure ganglion cells in the subject using the amplification signal. The apparatus may be used to count the number of normal ganglion cells in the retina by measuring a phase difference of two lights polarized in different directions. The apparatus may also be used to monitor the progress of glaucoma.

Abstract: Optical changes of tissue during wound healing measured by Near Infrared and Diffuse Reflectance Spectroscopy are shown to correlate with histologic changes. Near Infrared absorption coefficient correlated with blood vessel in-growth over time, while Diffuse Reflectance Spectroscopy (DRS) data correlated with collagen concentration. Changes of optical properties of wound tissue at greater depths are also quantified by Diffuse Photon Density Wave (DPDW) methodology at near infrared wavelengths. The diffusion equation for semi-infinite media is used to calculate the absorption and scattering coefficients based on measurements of phase and amplitude with a frequency domain or time domain device. An increase in the absorption and scattering coefficients and a decrease in blood saturation of the wounds compared to the non wounded sites was observed. The changes correlated with the healing stage of the wound.

Abstract: What is disclosed is a system and method for estimating color for pixels in an infrared image. In one embodiment, an infrared image is received which has been captured using a N-band infrared imaging system comprising a multi-spectral camera or a hyperspectral camera. The IR image is composed of an array of pixels with N intensity values having been collected for each pixel in the image. Then, for each pixel of interest, a search metric is used to search a database of vector samples to identify a visible-IR set which is closest to the intensity values of the IR band vector collected for the pixel. A visible vector representation is then estimated for the pixel based upon the visible portion corresponding to the closest visible-IR set. Thereafter, color coordinates for this pixel are computed from the visible vector. The method repeats for all pixels of interest in the IR image.

Abstract: An apparatus to interrogate, receive, and analyze full emission spectra for at least one fluorescence excitation wavelength and for at least one reflectance measurement to determine tissue characteristics. The apparatus includes a base unit having illumination, detection and control sub-units, the illumination sub-unit providing illumination optical energy for illuminating a target tissue and the detection sub-unit detecting tissue characteristics of a target tissue, a separate tissue interface unit, and a pathway coupling the base unit and the tissue interface unit. The system and apparatus may also include a tube for maintaining the distance between the tissue and units and for surrounding the tissue to prevent patient movement from being transmitted to the tissue.

Abstract: Frequent monitoring of early-stage burns is necessary for deciding optimal treatment and management. Superficial-partial thickness and deep-partial thickness burns, while visually similar, differ dramatically in terms of clinical treatment and are known to progress in severity over time. The disclosed method uses spatial frequency domain imaging (SFDI) far noninvasively mapping quantitative changes in chromophore and optical properties that may be an indicative of burn wound severity. A controlled protocol of graded burn severity is developed and applied to 17 rats. SFDI data is acquired at multiple near-infrared wavelengths over a course of 3 h. Burn severity is verified using hematoxylin and eosin histology. Changes in water concentration (edema), deoxygenated hemoglobin concentration, and optical scattering (tissue denaturation) are statistically significant measures, which are used to differentiate superficial partial-thickness burns from deep-partial thickness burns.

Abstract: The present invention relates to an apparatus 100 and, a method and a computer program for determining a parameter indicative of a tissue type of an associated tissue 116. In particular, the invention relates to an apparatus 100 comprising a spectrometer 102, which spectrometer comprises a light source 104 and a detector 106, 108 arranged to measure an optical spectrum. This enables determination of a first parameter being indicative of a bile concentration. As the inventors of the present invention have made the insight that bile concentration may serve as a discriminative feature for different tissue types, the apparatus is arranged to determine a second parameter indicative of a tissue type based on a concentration of bile. According to a specific embodiment, the apparatus further comprises an interventional device 112.

Abstract: A system for examining biological tissue of a subject includes a wireless optical probe, electronics and a processor. The wireless optical probe includes a light source connected to receive signals from a wireless receiver, and a light detector coupled to provide data to a wireless transmitter constructed to transfer data wirelessly. The wireless optical probe is powered by a battery. The light source is constructed and arranged to introduce optical radiation in the visible to infra-red range into the examined biological tissue of a subject, and the light detector is constructed and arranged to detect radiation that has migrated in the examined biological tissue of the subject. The electronics is constructed and arranged to communicate wirelessly with the optical probe, to store the transferred data, and to create optical data. The processor is constructed and arranged to evaluate the optical data.

Abstract: An optical measurement apparatus, to which a base end portion of a measurement probe introduced into a subject is connected so that scattering light from the subject through the measurement probe can be measured, includes: calibration member serving as an irradiation target of illumination light when a calibration process is performed for the measurement probe using the illumination light from the measurement probe; an insertion portion where a leading end of the measurement probe can be inserted; a housing portion that communicates with the insertion portion and accommodates the calibration member movably along a penetration direction of the insertion portion; a detection unit that detects insertion of the measurement probe when the calibration member reaches a predetermined position in the housing portion by the insertion of the measurement probe through the insertion portion; and a control unit that performs control for initiating the calibration process when the detection unit detects the insertion of the

Abstract: A method for demonstrating pre-emergent pimples is disclosed. The method includes providing a camera having a 25 mm macro lens and a linear polarizing filter including from 10 to 50 narrow band filters in the spectral range of 400-970 nm, and a light source having a linear polarizer oriented vertical to a polarization plane of the camera polarizer; taking a sequence of images of the face of a subject with the camera; creating an erythema map of the imaged area using oxy-hemoglobin values at each corresponding pixel; taking a visible-light image of the face of the subject; and comparing the images to see pre-emergent pimples. The method enables consumers to see pre-emergent pimples and treat them, which results in preventing the pimples from emerging or reducing the emergence of the pimples.

Abstract: Systems and methods are provided herein that generally involve measuring a prostate or other object. In some embodiments, a membrane can be sealed over a digit extension to form a closed volume. The closed volume can be inflated via an inflation tube, and a reference pattern can be disposed within the closed volume along with a measurement assembly. In use, a user can put on the glove, position the membrane in proximity to a rectal wall overlying a prostate, and inflate the membrane. As the user slides their finger across the rectal wall, optical fibers in the measurement assembly can move relative to a reference pattern, and a controller can sense light reflected through the fibers from the reference pattern. The controller can calculate or estimate various attributes of the prostate based on the reflected light, such as the palpable surface width or volume.

Abstract: Systems and methods are provided herein that generally involve measuring a prostate or other object. In some embodiments, a membrane can be sealed over a digit extension to form a closed volume. The closed volume can be inflated via an inflation tube, and a reference pattern can be disposed within the closed volume along with a measurement assembly. In use, a user can put on the glove, position the membrane in proximity to a rectal wall overlying a prostate, and inflate the membrane. As the user slides their finger across the rectal wall, optical fibers in the measurement assembly can move relative to a reference pattern, and a controller can sense light reflected through the fibers from the reference pattern. The controller can calculate or estimate various attributes of the prostate based on the reflected light, such as the palpable surface width or volume.

Abstract: A method of aiding in the diagnosis or prediction of degenerative joint disease in a joint of a patient. The method comprises obtaining a test spectrum of Raman scattered radiation from cartilage tissue in the joint, and analyzing the test spectrum, or one or more regions thereof, to assess whether the test spectrum is consistent with the patient having, or subsequently developing, degenerative joint disease in the joint.