Light Conducting Fiber Inserted Into A Body Patents (Class 600/478)
  • Patent number: 11513077
    Abstract: A general purpose sensor architecture integrating a surface enhanced Raman spectroscopy (SERS) substrate, a diffractive laser beam delivery substrate and a diffractive infrared detection substrate is provided that can be used to implement a low-cost, compact lab-on-a-chip biosensor that can meet the needs of large-scale infectious disease testing. The sensor architecture can also be used in any other application in which molecules present in the liquid, gaseous or solid phases need to be characterized reliably, cost-effectively and with minimal intervention by highly skilled personnel.
    Type: Grant
    Filed: October 13, 2021
    Date of Patent: November 29, 2022
    Inventor: Jonathan David Waldern
  • Patent number: 11503987
    Abstract: A plenoptic endoscope includes a fiber bundle with a distal end configured to receive light from a target imaging region, a sensor end disposed opposite the distal end, and a plurality of fiber optic strands each extending from the distal end to the sensor end. The plenoptic endoscope also includes an image sensor coupled to the sensor end of the fiber bundle, and a plurality of microlenses disposed between the image sensor and the sensor end of the fiber bundle, the plurality of microlens elements forming an array that receives light from one or more of the plurality of fiber optic strands of the fiber bundle and directs the light onto the image sensor. The plurality of microlens elements and the image sensor together form a plenoptic camera configured to capture information about a light field emanating from the target imaging region.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: November 22, 2022
    Assignee: Intuitive Surgical Operations, Inc.
    Inventor: Azad Shademan
  • Patent number: 11493692
    Abstract: The present disclosure relates to a laser probe assembly coupled to a laser system through an optical fiber cable. In one example, the laser probe assembly comprises a probe tip coupled to the probe body, the probe tip housing multiple fibers. Each of the multiple fibers comprises a proximal end that couples to the laser system and a distal end that terminates in the probe tip, a single core for transporting a laser beam provided by the laser system, and a cladding surrounding the core. The laser probe assembly also comprises a lens for projecting multiple laser beams provided by the multiple fibers on to a surgical site. Within the probe tip, parts of outer surfaces of portions of any two adjacent fibers of the multiple fibers touch. Also, the multiple fibers are at least substantially centered with respect to the lens.
    Type: Grant
    Filed: February 10, 2021
    Date of Patent: November 8, 2022
    Assignee: Alcon Inc.
    Inventors: Chenguang Diao, Mark Harrison Farley, Alireza Mirsepassi, Ronald T. Smith, Timothy C. Ryan
  • Patent number: 11480467
    Abstract: Wearable spectroscopy systems and methods for identifying one or more characteristics of a target object are described. Spectroscopy systems may include a light source configured to emit light in an irradiated field of view and an electromagnetic radiation detector configured to receive reflected light from a target object irradiated by the light source. One or more processors of the systems may identify a characteristic of the target object based on a determined level of light absorption by the target object. Some systems and methods may include one or more corrections for scattered and/or ambient light such as applying an ambient light correction, passing the reflected light through an anti-scatter grid, or using a time-dependent variation in the emitted light.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: October 25, 2022
    Assignee: MAGIC LEAP, INC.
    Inventors: Adrian Kaehler, Christopher M. Harrises, Eric Baerenrodt, Mark Baerenrodt, Nastasja U. Robaina, Nicole Elizabeth Samec, Tammy Sherri Powers, Ivan Li Chuen Yeoh, Adam Carl Wright
  • Patent number: 11482044
    Abstract: The invention relates to a free-beam interferometric method for illuminating a sequence of sectional areas in the interior of the light-scattering object. The method makes it possible for the user to select a larger image field and/or a higher image resolution than previously possible with the occurrence of self-interference of the specimen light from a scattering specimen.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: October 25, 2022
    Assignee: Visotec GmbH
    Inventors: Helge Sudkamp, Hendrik Spahr, Dierck Hillmann, Peter Koch, Gereon Huttmann
  • Patent number: 11460640
    Abstract: A fiber optic probe is provided with a distal sampling end, a proximal end, and light delivery and collection paths therethrough. The probe includes a window disposed at the distal sampling end of the fiber optic probe, the window having a distal end and a proximal end. A lens is disposed near the proximal end of the window, the lens having a distal end, a proximal end, and an aperture. A light delivery optical fiber is provided having a distal end and a proximal end, the light rays being directed through the aperture. A collection optical fiber is provided in optical communication with the lens and the window. The probe may include a lens collection filter disposed between the window and the lens and an optical isolator provided within the aperture to optically isolate the light delivery path and the light collection path.
    Type: Grant
    Filed: October 18, 2021
    Date of Patent: October 4, 2022
    Assignee: Captain JRT LLC
    Inventors: Eric Todd Marple, Kirk David Urmey, John Meckert
  • Patent number: 11445898
    Abstract: An optical module for endoscope includes an optical fiber, an optical element, a first substrate including, on a first principal plane, an insertion hole into which the optical fiber is inserted, the optical element being mounted on a second principal plane of the first substrate, a second substrate, on a third principal plane of which a recessed section in which the optical element is housed is present, and a solder ring that bonds a seal ring of the second principal plane of the first substrate and a guard ring of the third principal plane of the second substrate. The first substrate and the second substrate have the same external dimension in an optical axis orthogonal direction, and side surfaces of the first substrate and the second substrate are present in the same plane.
    Type: Grant
    Filed: January 18, 2019
    Date of Patent: September 20, 2022
    Assignee: OLYMPUS CORPORATION
    Inventor: Yusuke Nakagawa
  • Patent number: 11412932
    Abstract: The present disclosure is directed to instruments and methods that provide one or more stimulations with multiple fibers and multiple imaging implants inserted in a subject for capturing images from one or more regions of the subject's brain. The microendoscope can include a single spatial light modulator or multiple spatial light modulators, a furcated imaging fiber bundle with multiple fibers, multi-implants coupled to a subject for multi-implant patterned brain imaging and stimulation. Both the single spatial light modulator and multiple spatial light modulators are capable to project optical patterns to different imaging fibers and thereby stimulate multiple regions of the brain.
    Type: Grant
    Filed: November 18, 2018
    Date of Patent: August 16, 2022
    Assignee: PHOTONEDGE, INC.
    Inventor: Song Peng
  • Patent number: 11389051
    Abstract: The present disclosure provides systems and methods for medical imaging. The system may comprise an optical adapter. The optical adapter may comprise a housing that comprises (1) a first end configured to releasably couple to a scope and (2) a second end configured to releasably couple to a camera. The optical adapter may comprise an image sensor coupled to the housing. The optical adapter may comprise an optics assembly disposed in the housing. The optics assembly may be configured to (1) receive light signals that are reflected from a target site within a subject's body and transmitted through the scope, and (2) reflect a first portion of the light signals onto the image sensor while permitting a second portion of the light signals to pass through to the camera.
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: July 19, 2022
    Assignee: Activ Surgical, Inc.
    Inventors: Stephen Tully, John Oberlin, Emanuel DeMaio, Liam O'Shea, Vasiliy Buharin, Thomas Calef
  • Patent number: 11376007
    Abstract: An adapter assembly for connecting a handle assembly with a loading unit is provided. The adapter assembly includes a housing, an elongate body extending from the housing, and a trocar assembly supported within the elongate body and including a trocar member. The trocar member extends from the elongate body and is magnetized. Also provided are various assemblies for protecting the distal end of a surgical stapler during introduction of the surgical stapler within a patient.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: July 5, 2022
    Assignee: Covidien LP
    Inventors: David Racenet, Russell Pribanic, Stanislaw Marczyk
  • Patent number: 11360296
    Abstract: An imaging system is described for measuring the position or movement of a particle having a size of less than about 20 microns. The system comprises an optional sample holder configured to hold a sample with a particle, an optional illumination source configured to illuminate the sample, a lens having a magnification ratio from about 1:5 to about 5:1 and configured to generate the image of the sample, an image sensor having a pixel size of up to about 20 microns and configured to sense the image of the sample, and an image processor operatively connected to the image sensor to process the image of the particle in order to determine the position or movement of the particle. The dimension of the image of each particle is at least about 1.5 times the dimension of the particle multiplied by the magnification ratio of the lens, and the image of each particle is distributed on at least two pixels of the sensor. The imaged area of the sample is at least about one millimeter squared.
    Type: Grant
    Filed: September 4, 2020
    Date of Patent: June 14, 2022
    Assignee: Scanogen Inc
    Inventors: Zhiguang Xu, Alfredo Andres Celedon
  • Patent number: 11330969
    Abstract: An optical endoluminal far-field microscopic imaging catheter comprises a light generating system, a first light delivery conduit for propagating light generated by the light generating system and a light distributor configured to redirect light propagated by the delivery conduit into a direction of an object to be imaged. A discriminator is configured for capturing light reflected from the object incident on a window of the discriminator from a particular direction and transmitting only the light captured from the particular direction to a second light delivery conduit. A drive mechanism is configured to sweep the window through a plurality of directions in a predictable pattern for matching each light capture event in the window with a direction of the window during the event. An analyzer matches the direction of the window with an associated light capture event and generate a visible image based on a mosaic of the captured light.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: May 17, 2022
    Inventor: Jaywant Philip Parmar
  • Patent number: 11324387
    Abstract: Medical borescopes and related methods. In some embodiments, a medical borescope may comprise a handle and a tube extending from the handle. The tube may be partially, or wholly, defined by an at least substantially non-conductive material, such as a suitable plastic, ceramic, or other non-metallic material. The borescope may further comprise a tip assembly positioned at a distal end of the tube, which may comprise an image sensor configured to take images through the distal end of the tube.
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: May 10, 2022
    Assignee: Xenocor, Inc.
    Inventors: John Langell, Lane Brooks
  • Patent number: 11317890
    Abstract: A catheter is disclosed with a priming hole for exhaust at a distal portion of the catheter, the priming hole being used when filling with a priming solution is performed, and movably and rotatably accommodates an imaging core. The catheter includes a first connector that is provided at a rear end portion of the catheter and is supported by a fixed connector portion of a motor drive unit included in an imaging apparatus for diagnosis and a second connector that is supported by a movable connector portion of the motor drive unit. The catheter includes a reservoir, which is provided in the first connector and has a volume which decreases depending on a pull-out length of the second connector from the first connector, and a supply route, through which a priming solution injected from a priming injection port is supplied to the reservoir.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: May 3, 2022
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventor: Yuuki Sakaguchi
  • Patent number: 11304669
    Abstract: An X-ray diagnosis apparatus according to an embodiment includes processing circuitry. The processing circuitry is configured to extract a characteristic site in a lumen that may be a constraint during insertion of a surgical device, from medical image data used for determining a path through which the surgical device is to be inserted. On the basis of the characteristic site, the processing circuitry is configured to determine a tip end direction defined in accordance with a curved shape of a tip end part of the surgical device, in each of a plurality of positions on the path. The processing circuitry is configured to output path information including the tip end direction in each of the positions on the path.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: April 19, 2022
    Assignee: CANON MEDICAL SYSTEMS CORPORATION
    Inventor: Takahiko Nishioka
  • Patent number: 11307407
    Abstract: A two-dimensional optical scanning mirror device, a manufacturing method for the same, a two-dimensional optical scanning device and an image projector. A two-dimensional optical scanning mirror device includes a substrate, a movable mirror portion supported on the substrate in such a manner that two-dimension optical scanning is possible, a hard magnetic thin film provided in the movable mirror portion and a magnetic field generator that includes at least an alternating magnetic field generator for driving the movable mirror portion, where the hard magnetic thin film has a magnetization direction in a direction of a film plane, and the ratio of the magnetic field generated by the magnetic field generator relative to the coercive force of the hard magnetic thin film is 0.2 or lower.
    Type: Grant
    Filed: April 27, 2020
    Date of Patent: April 19, 2022
    Assignee: NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF FUKUI
    Inventors: Toshio Katsuyama, Ryoya Ishigami
  • Patent number: 11259799
    Abstract: A surgical instrument for use by an operator in a surgical procedure includes an elongate shaft, an end effector extending from the elongate shaft, and a control system. The end effector is articulatable relative to the elongate shaft between a home state position and an articulated position. The control system includes a processor and a memory coupled to the processor to store program instructions. The processor can alert the operator when the end effector reaches the home state position from the articulated position.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: March 1, 2022
    Assignee: Cilag GmbH International
    Inventors: Mark D. Overmyer, Brett E. Swensgard, Shane R. Adams, Thomas W. Lytle, IV, Richard L. Leimbach, Frederick E. Shelton, IV, Kevin L. Houser
  • Patent number: 11253209
    Abstract: An analyzer (124) includes a quantifier (204) configured to quantify an amount of contrast material representing scar tissue created by ablation for tissue of interest in contrast enhanced imaging data and a recommender (210) configured to generate a signal indicative of a recommendation to further ablate the tissue of interest in response to the quantified amount of the contrast material not satisfying a pre-determined threshold. A method includes obtaining contrast enhanced image data indicative of scar tissue created by ablation of tissue of interest, quantifying an amount of contrast material for the scar tissue in the tissue of interest, and generating a signal indicative of a recommendation to further ablate the tissue of interest in response to the quantified amount of the contrast material not satisfying a pre-determined threshold.
    Type: Grant
    Filed: November 1, 2012
    Date of Patent: February 22, 2022
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Robert Manzke, Roland Proksa, Anne Morawski Neubauer, Carsten Oliver Schirra
  • Patent number: 11246476
    Abstract: A system is provided for identifying the sufficiency of lesions formed during a tissue ablation procedure. The system and method include administering an ICG composition to the patient and forming one or more lesions at a surgical site. The method further includes applying energy of a type and in an amount sufficient to cause ICG in the patient to fluoresce. An image of the tissue and lesion at the surgical site is obtained while the ICG fluoresces. The lesion is distinguished from surrounding de novo tissue based on areas of fluorescence to allow a user to evaluate the quality of the lesion.
    Type: Grant
    Filed: January 28, 2019
    Date of Patent: February 15, 2022
    Assignee: CARDIOFOCUS, INC.
    Inventor: Gerald Melsky
  • Patent number: 11251005
    Abstract: An on/off switching circuit includes an on/off switch switchable between an on state and an off state, an light emitting diode (LED) driver to power one or more LEDs to illuminate an area of interest, a switch control unit to transition the on/off switch between the on and off states, the switch control unit including a light sensing circuit comprising at least one LED of the LEDs as a light sensor, and a bi-directional gate circuit. When the on/off switch is in the off state the bi-directional gate is in a first conducting state in which the bi-directional gate circuit connects the light sensor to the light sensing circuit, and when the on/off switch is in the on state the bi-directional gate is in a second conducting state in which the bi-directional gate connects the LED driver to the one or more LEDs including the light sensor.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: February 15, 2022
    Assignee: GIVEN IMAGING LTD.
    Inventor: Arkadiy Morgenshtein
  • Patent number: 11234600
    Abstract: This invention is regarding a set of stand-alone or combined-use surgical tools and associated systems and methods for performing surgical procedures such as identifying hidden tissue anatomy and dissecting the periphery tissues. In particular, this invention describes tools and the associated systems and methods for visualizing hidden important structures such as arteries, veins, ureters, bile duct, bowel, nodules, tumors, and performing tissue cutting using energy-based instrument. The tools are to be operated stand-alone or by attaching to existing instruments used for minimally invasive surgery.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: February 1, 2022
    Assignee: THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY
    Inventor: Daqing Piao
  • Patent number: 11067792
    Abstract: A two-dimensional optical scanning mirror device, a manufacturing method for the same, a two-dimensional optical scanning device and an image projector. A two-dimensional optical scanning mirror device includes a substrate, a movable mirror portion supported on the substrate in such a manner that two-dimension optical scanning is possible, a hard magnetic thin film provided in the movable mirror portion and a magnetic field generator that includes at least an alternating magnetic field generator for driving the movable mirror portion, where the hard magnetic thin film has a magnetization direction in a direction of a film plane, and the ratio of the magnetic field generated by the magnetic field generator relative to the coercive force of the hard magnetic thin film is 0.2 or lower.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: July 20, 2021
    Assignee: NATIONAL UNIVERSITY CORPORATION UNIVERSITY OF FUKUI
    Inventors: Toshio Katsuyama, Ryoya Ishigami
  • Patent number: 11027114
    Abstract: A blood pump assembly can include various components such as a housing and a sensor configured to detect one or more characteristics of the blood. In some embodiments, the sensor can be coupled to the housing and can include a sensor membrane configured to deflect in response to a change in a blood parameter (e.g., pressure). The blood pump assembly can include a shield that covers at least a portion of the sensor membrane so as to protect the sensor from damage when the blood pump assembly is inserted through an introducer and navigated through the patient's vasculature and/or when the blood pump assembly is inserted into the heart in a surgical procedure. One or more protective layers can be deposited over the sensor membrane to prevent the sensor membrane from being dissolved through interactions with the patient's blood.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: June 8, 2021
    Assignee: ABIOMED, INC.
    Inventors: Ralph Louis D'Ambrosio, Bruce Adams, Michael Thomas Finnegan, Gerd Spanier, Thorsten Siess
  • Patent number: 10994095
    Abstract: A system for deploying a device includes an elongated flexible instrument (108) and a shape sensing system (104) coupled to the flexible instrument. A hub (106) includes a shape profile configured to receive and maintain the flexible instrument with the shape sensing system therein. The shape profile includes a shape to track a position or a rotation of the hub relative to a reference position using the shape sensing system. The hub is configured to be coupled to a deployable device (102) such that a change in the position or rotation of the hub indicates a corresponding change in the deployable device.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: May 4, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Molly Lara Flexman, Sander Hans Denissen, David Paul Noonan, Neriman Nicoletta Kahya, Aryeh Leib Reinstein
  • Patent number: 10959627
    Abstract: A system may include an expandable member, and a plurality of sensors disposed on an outer surface of the expandable member and circumferentially spaced apart from one another, wherein each of the plurality of sensors includes a first emitter configured to emit light of a first wavelength, and a detector configured to detect light, and a controller coupled to the plurality of sensors.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: March 30, 2021
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: George Wilfred Duval, Michael Y. Ko, James Weldon, Namita M. Kallur
  • Patent number: 10942112
    Abstract: Exemplary apparatus and method can be provided for obtaining data regarding a plurality of samples. For example, using at least one arrangement, it is possible to receive interferometric information that is based on radiations provided from a reference and the samples that are provided in respective chambers. Alternatively and/or in addition, based on the interferometric information, it is possible to discriminate between agents to identify a particular agent that affects a particular function within at least one of the samples.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: March 9, 2021
    Assignees: The General Hospital Corporation, The UAB Research Foundation
    Inventors: Steven M. Rowe, Guillermo J. Tearney, Brett Eugene Bouma, Linbo Liu, Eric J. Sorscher, Kengyeh Ken Chu, Bradford James Diephuis, Eric James Wilsterman, Gregory Andrew Dierksen
  • Patent number: 10921182
    Abstract: A device includes a scattering structure and a collection structure. The scattering structure is arranged to concurrently scatter incident electromagnetic radiation along a first scattering axis and along a second scattering axis. The first scattering axis and the second scattering axis are non-orthogonal. The collection structure includes a first input port aligned with the first scattering axis and a second input port aligned with the second scattering axis. A method includes scattering electromagnetic radiation along a first scattering axis to create first scattered electromagnetic radiation and along a second scattering axis to create second scattered electromagnetic radiation. The first scattering axis and the second scattering axis are non-orthogonal. The first scattered electromagnetic radiation is detected to yield first detected radiation and the second scattered electromagnetic radiation is detected to yield second detected radiation.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: February 16, 2021
    Assignee: TAIWAN SEMICONDUCTOR MANUFACTURING COMPANY LIMITED
    Inventors: Chewn-Pu Jou, Fen Wei Kuo, Huan-Neng Chen, Lan-Chou Cho
  • Patent number: 10914683
    Abstract: The invention relates to a method for identification and discrimination of bacteria and/or mutant bacterial strains in a biological fluid. The method includes illuminating the biological fluid with a beam of light; obtaining Raman data from light scattered from the illuminated biological fluid; and finding Raman signatures corresponding to each type of bacteria and/or mutant bacterial strains from the obtained Raman data, so as to identify and discriminate each type of bacteria and/or mutant bacterial strains in the biological fluid from the Raman signatures.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: February 9, 2021
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Anita Mahadevan-Jansen, Oscar D. Ayala, Eric P. Skaar, Catherine A. Wakeman, Jay A. Werkhaven
  • Patent number: 10891730
    Abstract: Implementations of the present disclosure include methods, systems, and computer-readable storage mediums for image reconstruction. Actions include receiving an image acquired by an endoscopic system including an optical fiber bundle with multiple optical fibers, each optical fiber being surrounded by cladding, determining in the image fiber core locations corresponding to the optical fibers, reconstructing missing information from the image using interpolation performed in accordance with the fiber core locations, the missing information corresponding to artifacts in the acquired image that result from the cladding, and providing a fiber-pattern removed image, in which the artifacts in the acquired image are removed using the missing information.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: January 12, 2021
    Assignee: University of Southern California
    Inventors: Pu Wang, Francesco Cutrale, Scott E. Fraser
  • Patent number: 10881301
    Abstract: Systems and methods for spatial optimization of blood measurements in tissue are disclosed. Exemplary methods include: measuring a first Raman signal from the tissue with a probe at a first position; calculating a first percentage of a blood component in the first Raman signal; moving the probe a predetermined distance to a second position; measuring a second Raman signal with the probe at the second position; calculating a second percentage of the blood component in the second Raman signal; moving the probe the predetermined distance to a third position when the second percentage is greater than the first percentage; measuring a third Raman signal with the probe at the third position; calculating a third percentage of the blood component in the third Raman signal; moving the probe to the second position when the third percentage is less than the second percentage; and taking spectral measurements from the second position.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: January 5, 2021
    Assignee: BioSpex, Inc.
    Inventors: Clint Periaki, Wei Yang, Jiani Huang
  • Patent number: 10845241
    Abstract: The present disclosure provides a method of providing a hyperspectral image of a scene comprising a point (p).
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: November 24, 2020
    Assignee: Glana Sensors AB
    Inventors: Jörgen Ahlberg, Ingmar Renhorn
  • Patent number: 10794831
    Abstract: An organic compound analyzer is provided which is capable of highly accurately determining a denaturation feature point on which a minute structural change of an organic compound is reflected. The organic compound analyzer includes an actual measured data storage section, an evaluation criterion vector setting section, a score calculation section, and a change feature point determination section. The actual measured data storage section is configured to store in pairs a plurality of actual measured spectra obtained through measurement of a sample containing an organic compound under a plurality of different external stimulus conditions, and external stimulus conditions under which spectra are respectively measured. The evaluation criterion vector setting section is configured to set a loading that indicates weighting to individual wavenumbers at which the spectra are measured.
    Type: Grant
    Filed: August 8, 2017
    Date of Patent: October 6, 2020
    Assignee: HORIBA, LTD.
    Inventor: Chikashi Ota
  • Patent number: 10791983
    Abstract: Methods, apparatuses, and systems for measuring collagen organization in the cervix, assessing the health of a woman's cervix (including a pregnant woman's cervix), characterizing the composition and structure of cervical tissue, and measuring preterm labor risk are provided. Polarization sensitive techniques and properties of cervical tissue, including birefringence, can be used. A method can include acquiring in vivo images of cervical tissue, applying Mueller matrix (MM) polarimetry (including 4×4 Mueller matrix polarimetry), and determining one or more parameters of the cervical tissue using the Mueller matrix (MM) polarimetry. The in vivo images can be analyzed and various parameters that characterize the cervical tissue can be determined. Graphs and maps of the cervical tissue can be generated for use as care provider tools.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: October 6, 2020
    Assignee: The Florida International University Board of Trustees
    Inventor: Jessica Ramella-Roman
  • Patent number: 10768406
    Abstract: An imaging system is described for measuring the position or movement of a particle having a size of less than about 20 microns. The system comprises an optional sample holder configured to hold a sample with a particle, an optional illumination source configured to illuminate the sample, a lens having a magnification ratio from about 1:5 to about 5:1 and configured to generate the image of the sample, an image sensor having a pixel size of up to about 20 microns and configured to sense the image of the sample, and an image processor operatively connected to the image sensor to process the image of the particle in order to determine the position or movement of the particle. The dimension of the image of each particle is at least about 1.5 times the dimension of the particle multiplied by the magnification ratio of the lens, and the image of each particle is distributed on at least two pixels of the sensor. The imaged area of the sample is at least about one millimeter squared.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: September 8, 2020
    Assignee: Scanogen Inc.
    Inventors: Zhiguang Xu, Alfredo Andres Celedon
  • Patent number: 10606064
    Abstract: A device comprises a light-guiding component, an optical component, and a light-reflecting component that is configured to receive light from the optical component and direct the light along a path. Also, at least one of the optical component and the light-reflecting component has an optical power in a tangential direction or a sagittal direction that compensates for a negative power of a sheath in the tangential direction to correct for aberration.
    Type: Grant
    Filed: January 24, 2018
    Date of Patent: March 31, 2020
    Assignee: Canon U.S.A., Inc.
    Inventor: Tzu-Yu Wu
  • Patent number: 10591483
    Abstract: [Problem] To provide a method for acquisition of data able to serve as an index for determining the likelihood that an ovarian endometriosis cyst is cancerous. Solution This data acquisition method for determining the likelihood that an ovarian endometriosis cyst is cancerous includes an iron concentration measurement step for measuring the iron concentration in the cystic fluid of the ovarian endometriosis cyst. This diagnostic device for diagnosing the likelihood that an ovarian endometriosis cyst is cancerous is provided, at a minimum, with an iron concentration measurement unit for measuring the iron concentration in the cystic fluid of the ovarian endometriosis cyst.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: March 17, 2020
    Assignee: CELLSPECT CO., LTD.
    Inventors: Hiroshi Kobayashi, Chiharu Yoshimoto, Junko Takahama, Takuya Iwabuchi
  • Patent number: 10590493
    Abstract: The invention provides methods and devices for generating optical pulses in one or more waveguides using a spatially scanning light source. A detection system, methods of use thereof and kits for detecting a biologically active analyte molecule are also provided. The system includes a scanning light source, a substrate comprising a plurality of waveguides and a plurality of optical sensing sites in optical communication with one or more waveguide of the substrate, a detector that is coupled to and in optical communication with the substrate, and means for spatially translating a light beam emitted from said scanning light source such that the light beam is coupled to and in optical communication with the waveguides of the substrate at some point along its scanning path. The use of a scanning light source allows the coupling of light into the waveguides of the substrate in a simple and cost-effective manner.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: March 17, 2020
    Assignee: LDIP, LLC
    Inventors: Reuven Duer, Yun-Pei Chang, Ashutosh Shastry
  • Patent number: 10537242
    Abstract: An imaging apparatus includes a converter configured to convert an analog signal obtained from detected interference light into a digital signal and a clock generator configured as an interferometer including an optical path through which part of light emitted from a light source passes, the optical path being split into a first optical path and a second optical path having an optical path length difference therebetween, to generate a clock used by the converter sampling the analog signal at a frequency corresponding to the optical path length difference. The converter includes n A/D converters, n being an integer of at least 2, and is configured to change phases of n clocks obtained from the clock to produce a phase difference therebetween, and to generate a clock having an n-times frequency from the n clocks and n analog signals obtained from the analog signal using the n A/D converters.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: January 21, 2020
    Assignee: Canon Kabushiki Kaisha
    Inventors: Taro Fukasawa, Takashi Naba, Yasuhisa Inao
  • Patent number: 10463876
    Abstract: This disclosure provides a photodynamic therapy diagnostic device capable of optical fiber puncture. This device comprises an optical fiber, a laser, a spectrocoupler and a fluorescence analyzer; in which the optical fiber comprises a body portion and a puncture needle head, one end of the body portion is connected with the puncture needle head, and the other end is connected with the spectrocoupler; in which the spectrocoupler is connected with the laser and the fluorescence analyzer to enable a laser emitted by the laser to enter the optical fiber via the spectrocoupler, and a fluorescence produced by the photosensitizer after absorbing the laser to enter fluorescence analyzer via the optical fiber and the spectrocoupler. This therapy diagnostic device, the laser emits a laser with a wavelength that can be absorbed by the photosensitive drug; the laser can pass through the spectrocoupler and then pass through the optical fiber needle tubing, so as to reach the tumor site in the body.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: November 5, 2019
    Inventor: Hua Shang
  • Patent number: 10426326
    Abstract: An optical probe for use in medical instrumentation where a sheath is covering the optical probe, wherein the optical probe is configured to correct astigmatism by incorporating asymmetric optical powers.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: October 1, 2019
    Assignee: Canon U.S.A, Inc.
    Inventor: Daisuke Yamada
  • Patent number: 10376136
    Abstract: There is provided a camera head for endoscope which enables to achieve a favorable fluorescent image in any wavelength band when the observation is switched over from a normal white-light image observation to an observation of fluorescent images of different wavelength bands.
    Type: Grant
    Filed: August 29, 2017
    Date of Patent: August 13, 2019
    Assignee: OLYMPUS CORPORATION
    Inventors: Takayuki Kato, Makoto Tomioka, Takahiro Inoue, Kazuo Morita
  • Patent number: 10363090
    Abstract: A catheter probe comprises an insertion tube, and a distal end with a distal electrode, a force sensor to detect force on the distal electrode, and an irrigated electrode mounted on a coupling member of the force sensor, which has a tubular form surrounding a central space occupied by components, including force sensing coils. A fluid diverter that passes fluid to the proximal irrigated electrode is configured as an insert or an integrated projection of the coupling member, which configuration minimizes its space demand within the coupling member. Thus, the diameter of the distal end need not be increased. The fluid diverter has a proximal entry opening and a distal exit opening connected by a fluid passage with at least a radial branch and at least an axial branch. The irrigated electrode is mounted over the distal exit opening to receive fluid from the fluid passage.
    Type: Grant
    Filed: January 5, 2016
    Date of Patent: July 30, 2019
    Assignee: Biosense Webster (Israel) Ltd.
    Inventors: Christopher Thomas Beeckler, Assaf Govari, Rowan Olund Hettel, Tom Allen Ditter
  • Patent number: 10342906
    Abstract: A blood pump assembly can include various components such as a housing and a sensor configured to detect one or more characteristics of the blood. In some embodiments, the sensor can be coupled to the housing and can include a sensor membrane configured to deflect in response to a change in a blood parameter (e.g., pressure). The blood pump assembly can include a shield that covers at least a portion of the sensor membrane so as to protect the sensor from damage when the blood pump assembly is inserted through an introducer and navigated through the patient's vasculature and/or when the blood pump assembly is inserted into the heart in a surgical procedure. One or more protective layers can be deposited over the sensor membrane to prevent the sensor membrane from being dissolved through interactions with the patient's blood.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: July 9, 2019
    Assignee: ABIOMED, INC.
    Inventors: Ralph Louis D'Ambrosio, Bruce Adams, Michael Thomas Finnegan, Gerd Spanier, Thorsten Siess
  • Patent number: 10335015
    Abstract: Medical borescopes and related methods. In some embodiments, a medical borescope may comprise a handle and a tube extending from the handle. The tube may be partially, or wholly, defined by an at least substantially non-conductive material, such as a suitable plastic, ceramic, or other non-metallic material. A tip assembly may be positioned at a distal end of the tube. The tip assembly may comprise a light source, a lens assembly, a printed circuit board, and an image sensor.
    Type: Grant
    Filed: April 13, 2018
    Date of Patent: July 2, 2019
    Assignee: Xenocor, Inc.
    Inventors: John Langell, Lane Brooks
  • Patent number: 10322028
    Abstract: An apparatus for delivering therapeutic agent to an eye comprises a body, a cannula, a hollow needle, an actuation assembly, and a detection/visualization system. The cannula extends distally from the body and is sized and configured to be insertable between a choroid and a sclera of a patient's eye. The actuation assembly is operable to actuate the needle relative to the cannula to thereby drive a distal portion of the needle along an exit axis. The cannula may be inserted through a sclerotomy incision and advanced through the choroid to deliver the therapeutic agent adjacent to the potential space between the neurosensory retina and the retinal pigment epithelium layer. The detection/visualization system is operable to detect or visualize penetration of the choroid of a patient's eye and provide feedback to the operator and/or automatic control of the apparatus based on penetration of the choroid.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: June 18, 2019
    Assignee: ORBIT BIOMEDICAL LIMITED
    Inventors: Daniel W. Price, Brendan J. Oberkircher, Saeed Sokhanvar, Daniel J. Yasevac, Michel Bruehwiler, Leah R. Soffer, Gregory W. Johnson, William D. Dannaher, Stefan Troller, Urban Schnell, Jean Christophe Roulet, Alain Saurer, Michael F. Keane
  • Patent number: 10285583
    Abstract: A scanning optical probe and method includes a cannula, optical fiber, lens, and an actuating mechanism for tilting the optical fiber back and forth within the cannula. An actuator in the probe handle is coupled to various flexing and guide components extending through the cannula and towards the distal end of the scanning optical probe. Reciprocating motion from the actuator is transmitted to the components thereby causing the optical fiber at the distal end of the scanning optical probe to aim across target surfaces. The light emitted from the optical fiber is processed to generate a scan of the target area.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: May 14, 2019
    Assignee: Novartis AG
    Inventors: Kambiz Parto, Edouard G. Schmidtlin, Barry L. Wheatley
  • Patent number: 10275908
    Abstract: According to one embodiment, a medical image diagnostic apparatus includes a storage memory, processing circuitry, and a display. The storage memory stores data of a plurality of FFR distribution maps constituting a time series regarding a coronary artery, and data of a plurality of morphological images corresponding to the time series. The processing circuitry converts the plurality of FFR distribution maps into a plurality of corresponding color maps, respectively. The display displays a plurality of superposed images obtained by superposing the plurality of color maps and the plurality of morphological images respectively corresponding in phase to the plurality of color maps. The display restricts display targets for the plurality of color maps based on the plurality of FFR distribution maps or the plurality of morphological images.
    Type: Grant
    Filed: November 10, 2017
    Date of Patent: April 30, 2019
    Assignee: Toshiba Medical Systems Corporation
    Inventors: Hideaki Ishii, Satoshi Wakai, Kazumasa Arakita, Takuma Igarashi, Yasuko Fujisawa, Shigeo Kaminaga, Kenji Hirohata, Junichiro Ooga
  • Patent number: 10154779
    Abstract: An illuming device for use in medically illuminating tissue of interest within a patient generally includes a light diffusing optical fiber and an at least partially optically opaque sheath that is mounted over the fiber for selective, sliding movement along the length thereof. By sliding the sheath relative to the optical fiber after it has been inserted into a patient to illuminate a particular area of tissue, the length, size, and/or shape of the light that is exposed to the tissue can be selectively controlled. Such in situ variation of the properties of the exposed light permit use of a single instrument and a single procedure regardless of variation in the size and shape of the diseased tissue being medically treated.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: December 18, 2018
    Assignee: CORNING INCORPORATED
    Inventors: William Spencer Klubben, III, Jeffrey L Mooney, Peter Gerard Wigley
  • Patent number: 10111586
    Abstract: A forward-imaging optical coherence tomography probe is provided, comprising: a substantially cylindrical housing comprising: a longitudinal axis; an interior side; a distal end that is optically transparent; and a mirror located at the interior side, adjacent the distal end; an optical fiber located inside the cylindrical housing along the longitudinal axis; a wedge lens located inside the cylindrical housing, adjacent the distal end, the wedge lens configured to receive light from the fiber, and direct the light towards the mirror; and, at least one motor configured to both: rotate the fiber and the wedge lens about the longitudinal axis and inside the cylindrical housing; and, linearly displace the fiber and the wedge lens along the longitudinal axis and inside the cylindrical housing; the mirror configured to: receive light from the wedge lens and reflect the light out of the distal end as the wedge lens moves linearly and rotationally.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: October 30, 2018
    Assignee: SYNAPTIVE MEDICAL (Barbados) Inc.
    Inventors: Fangxin Li, Michael Frank Gunter Wood
  • Patent number: 10105058
    Abstract: An apparatus for performing an endoscopic procedure for detecting cancerous tissue includes a detection probe for detecting the cancerous tissue. The detection probe includes a first fiber for emitting an ultraviolet light beam having an orthogonal function applied thereto and a second fiber for receiving emissions from tissues responsive to the ultraviolet light beam emitted for the first fiber. An ultraviolet emission source generates the ultraviolet light beam. Orthogonal function circuitry applies the orthogonal function twist to the ultraviolet light beam. Detection circuitry detects fluorescence and orthogonal function within the emissions from the tissues received over the second fiber.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: October 23, 2018
    Assignee: NXGEN PARTNERS IP, LLC
    Inventors: Solyman Ashrafi, Roger Linquist, Nima Ashrafi