Abstract: An imaging method includes providing a handpiece having a probe tip insertable into human or animal tissue disposed at an end thereof, and, an optical coherence tomography (OCT) probe connected to the handpiece such that a functionality of the OCT probe is provided at the probe tip. The probe tip is disposed adjacent to or into human or animal tissue. Imaging of the tissue, measuring at least one of a feature size or a quantifiable characteristic of a structure in the tissue for biometry analysis, and/or performing a diagnostic procedure on the tissue or a device implanted in the tissue is performed with the OCT probe.

Abstract: A catheter includes a catheter main body provided with a window portion through which an inspection wave passes, a drive shaft provided with a detection unit detecting the inspection wave and concurrently installed advanceably and retractably in an axial direction inside the catheter main body, and a bias member biasing a force onto the drive shaft for moving the drive shaft forward toward the distal side thereof.

Abstract: The delivery of biological compounds to ischemic and/or infarcted tissue are described herein where such a system may include a deployment catheter and an attached imaging hood deployable into an expanded configuration. In use, the imaging hood is placed against or adjacent to a region of tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid, such as saline, can be pumped into the imaging hood until the fluid displaces any blood, thereby leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. Additionally, any number of therapeutic tools can also be passed through the deployment catheter and into the imaging hood for performing any number of procedures on the tissue for identifying, locating, and/or accessing ischemic and/or infarcted tissue.

Abstract: Apparatus is provided for diagnosing or treating an organ or vessel, wherein a device having at optical fiber contact force sensors disposed in a distal extremity thereof and a deflection mechanism configured to deflect the elongate body at a location proximal of the distal extremity. The optical fiber contact force sensors are configured to be coupled to processing logic programmed which computes a force vector responsive to detected changes in the optical characteristics of the optical fiber contact force sensors arising from deflection of the distal extremity resulting from contact with the tissue of the wall of the organ or vessel.

Abstract: Biological tissue such as skeletal and cardiac muscle can be imaged by using an objective-based probe in the tissue and scanning at a sufficiently fast rate to mitigate motion artifacts due to physiological motion. According to one example embodiment, such a probe is part of a system that is capable of reverse-direction high-resolution imaging without needing to stain or otherwise introduce a foreign element used to generate or otherwise increase the sensed light. The probe can include a light generator for generating light pulses that are directed towards structures located within the thick tissue. The system can additionally include aspects that lessen adverse image-quality degradation. Further, the system can additionally be constructed as a hand-held device.

Abstract: Disclosed are fiber optic devices and related methods that allow for measurement of blood flow and oxygenation in real time. These devices have particular application to the spinal cord. Such devices have applicability in, for example, the care of military members sustaining combatant and noncombatant spinal injuries, as well as to civilians. The devices also have utility in the acute and subacute management of spine trauma, enhancing the efficacy of interventions aimed at the prevention of secondary ischemic injury, and ultimately improving neurologic outcome.

Abstract: A system, for use with a cannula insertable into human or animal tissue, for measuring relative motion during a surgical procedure includes a probe having a probe tip insertable into the cannula, and means for determining relative motion between the cannula and the probe tip.

Abstract: A system for characterising a material is provided. The system includes an optical sensor including an optical waveguide, the optical waveguide having first and second ends and being characterised by having a numerical aperture greater than or equal to 0.2, and a microresonator including an optically active material, the microresonator being positioned in an optical near field of an end face of the first end of the optical waveguide such that the optically active material is excitable by light. The system further includes a light source for exciting the optically active material of the microresonator so as to generate whispering gallery modes (WGMs) in the microresonator and a light collector for collecting an intensity of light that is associated with the WGMs excited in the microresonator.

Abstract: The present invention provides minimally invasive imaging probe having an optical encoder integrated therewith for accurately measuring or estimating the rotational velocity near the distal end of the medical device, such as an imaging probe which undergoes rotational movement during scanning of surrounding tissue in bodily lumens and cavities.

Abstract: A device is provided to confirm intratubal occlusion in a subject of a fallopian tube having an inner diameter that includes a tubular shaft having a distal end and an interior lumen. An examination head is joined to the distal end of the shaft. A visualization modality in the examination head provides visual or acoustic imaging of the fallopian tube. A power source for the visualization modality is provided. A handle is provided for control of the device. An ex vivo imager of an ocular, video headgear, or a video display is provided in communication with the visualization modality. A process for evaluating an intratubal implant in a fallopian tube through optical or sonic wave visualization is also provided.

Abstract: An optical fiber that transmits scanning light to a subject; a housing holding the optical fiber; a vibration element fixed to an exit end part of the fiber and vibrating periodically the exit end part so that the scanning light emitted from the exit end part scans on the subject in a predetermined trajectory; a hollow tube formed so an inner circumferential surface of the hollow tube positioned outside a moving range of the exit end part and the vibration element surrounds an entire circumference of the exit end part and a movable part of the vibration element; a thermal detection sensor detecting temperature in a hollow space of the hollow tube; and a heating element laid on one of the inner and outer circumferential surface of the hollow tube and increases the temperature in the hollow space in response to the temperature detected by the thermal detection sensor.

Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to Raman imaging devices (e.g., Raman endoscope probes) or systems, methods of using Raman agents, Raman imaging devices, and/or systems to image or detect a signal, and the like.

Abstract: The present invention discloses an optical microscopy probe (10) for scanning microscopy imaging of object (O). The probe has an optical window (22), and an optical guide (2) having an objective lens (6) rigidly coupled to an end portion of the optical guide. The optical guide is displaceably mounted in a transverse direction of the housing (21) so as to enable optical scanning in a region of interest (ROI). A relay lens unit (25) is rigidly mounted at the distal end (23) of the probe and it has a first lens (25a), a second lens (25b) and a mirror (25c), the relay lens unit being optically arranged relative to the objective lens for allowing scanning microscopy through the optical window of the housing. The invention is advantageous for obtaining an improvement in the available field of view of the probe because the cooperation between the displaceable objective lens and the relay lens unit may compensate for the relative limited free working distance of the objective lens.

Abstract: An optical source can generally provide optical energy having phase noise. Such phase noise, when demodulated using an intravascularly-deliverable optical fiber transducer, can be indistinguishable from a signal of interest. Apparatus or techniques can include using one or more of a reference optical cavity or a delay line, such as to obtain information indicative of the phase noise of the optical source. Such information can then be reduced or suppressed from other information obtained from the intravascularly-deliverable optical fiber transducer, such as to improve a signal-to-noise (SNR) ratio of a sensing system including the intravascularly-deliverable optical fiber transducer.

Abstract: An optical imaging diagnostic apparatus including: a designating unit for designating a predetermined circumferential-direction position at the circumference of the transmitting and receiving unit on the cross-sectional image displayed; an extraction unit for extracting, within the plurality of line data used for the generation of the cross-sectional image, line data corresponding to circumferential-direction position designated in the designating unit from the storage unit; a calculation unit for calculating attenuation rate in a predetermined region in a radial direction of a body lumen with respect to the extracted line data; and a display unit for displaying the calculated attenuation rate.

Abstract: In part, the invention relates to a catheter suitable for flushing a vessel. The catheter can include separated lumens and components that improve image data collection. In one embodiment, the catheter includes a catheter wall; a distal portion defining a distal lumen (62), the distal lumen having a first end terminating at the distal end of the catheter and a second end (30) terminating at an exit port in the catheter wall; a proximal portion defining proximal lumen (42), the proximal lumen having a first end terminating at the proximal end of the catheter and a second end terminating at a vent port (34) in the catheter wall; and a valve (50,54) positioned adjacent the vent port, the valve permitting fluid to exit the proximal lumen, but preventing particulate matter from the environment from entering the proximal lumen. In one embodiment, the valve comprises a piston (50) and spring (54) located in the proximal lumen (42).

Abstract: A surgical imaging device includes at least one light source for illuminating an object, at least two image sensors configured to generate image data corresponding to the object in the form of an image frame, and a video processor configured to receive from each image sensor the image data corresponding to the image frames and to process the image data so as to generate a composite image. The video processor may be configured to normalize, stabilize, orient and/or stitch the image data received from each image sensor so as to generate the composite image. Preferably, the video processor stitches the image data received from each image sensor by processing a portion of image data received from one image sensor that overlaps with a portion of image data received from another image sensor.

Abstract: Technologies generally applicable to detecting skin conditions are disclosed. A computer graphics scanning apparatus may be configured to capture skin image data, and use the captured skin image data to calculate a subsurface transfer function for the skin, which may identify subsurface properties of the skin. The identified subsurface properties may be correlated to one or more skin conditions for medical and/or cosmetic treatment diagnosis.

Abstract: A method of monitoring a subject includes attaching a sensor module having at least one optical emitter and detector to a body of the subject, delivering light from the at least one optical emitter into the body of the subject via a first light guide that is in optical communication with the at least one optical emitter, and collecting light from the body of the subject via a second light guide that is in optical communication with the at least one optical detector. The first light guide has a proximal end optically coupled to the at least one optical emitter and delivers light from the at least one optical emitter via a distal end thereof. The second light guide has a proximal end optically coupled to the at least one optical detector and collects light from the body of the subject via the distal end thereof.

Abstract: An intravascular sensor delivery device for measuring a physiological parameter of a patient, such as blood pressure, within a vascular structure or passage. In some embodiments, the device can be used to measure the pressure gradient across a stenotic lesion or heart valve. For example, such a device may be used to measure fractional flow reserve (FFR) across a stenotic lesion in order to assess the severity of the lesion. The sensor delivery device has a distal sleeve configured to pass or slide over a standard medical guidewire. Some distance back from the sensor and distal sleeve, the device separates from the guidewire to permit independent control of the sensor delivery device and the guidewire. The sensor delivery device can be sized to pass over different sizes of guidewires to enable usage in coronary and peripheral arteries, for example.

Abstract: Navigational imaging system and method for use in branched luminal structure. Flexible, spatially steerable probe is equipped with forward- and side-imaging mutually complementing means to enable sub-surface imaging, quantitative determination of probe's positioning with respect to anatomical identifiers of structure, forming 3D image of structure in a volume defined by the imaging means, and positioning of probe in registration with a 3D coordinate system that is independent from the structure. Method includes determining anatomical identifiers of luminal structure branches based on 3D and sub-surface images, assigning such identifiers as fiducial points, and correlating the determined identifiers with those obtained from anatomical model to select target branch for further steering the probe.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device includes a pressure sensing guidewire. The pressure sensing guidewire may include a tubular member having a proximal portion and a distal portion. The distal portion may have a plurality of slots formed therein. The distal portion may have a first wall thickness along a first region and a second wall thickness different from the first wall thickness along a second region. A pressure sensor may be disposed within the distal portion of the tubular member.

Abstract: The invention is a system comprising a guidewire having expanded imaging capabilities and a processor for processing the image data and causing relevant information, such as flow, to be displayed. The system is configured to cause image data to be processed and reconfigured in a user friendly format, e.g., color-coded, to provide details of flow and device placement within a biological lumen.

Abstract: A medical imaging system, the medical imaging system may include a non-coherent fiber bundle that comprises multiple fibers; wherein each of the multiple fibers has a distal end and a proximal end; at least one lens optically coupled to the non-coherent fiber bundle; an imaging sensor that is arranged to receive light received from the non-coherent fiber bundle and to generate detection signals; and a non-volatile memory module that stores mapping information that associates between locations of distal ends and proximal ends of the multiple fibers.

Abstract: Exemplary apparatus and process can be provided for imaging information associated with at least one portion of a sample. For example, (i) at least two first different wavelengths of at least one first electro-magnetic radiation can be provided within a first wavelength range provided on the portion of the sample so as to determine at least one first transverse location of the portion, and (ii) at least two second different wavelengths of at least one second electro-magnetic radiation are provided within a second wavelength range provided on the portion so as to determine at least one second transverse location of the portion. The first and second ranges can east partially overlap on the portion. Further, a relative phase between at least one third electro-magnetic radiation electro-magnetic radiation being returned from the sample and at least one fourth electro-magnetic radiation returned from a reference can be obtained to determine a relative depth location of the portion.

Abstract: Systems and methods are provided herein that generally involve measuring a prostate or other object. In some embodiments, a membrane can be sealed over a digit extension to form a closed volume. The closed volume can be inflated via an inflation tube, and a reference pattern can be disposed within the closed volume along with a measurement assembly. In use, a user can put on the glove, position the membrane in proximity to a rectal wall overlying a prostate, and inflate the membrane. As the user slides their finger across the rectal wall, optical fibers in the measurement assembly can move relative to a reference pattern, and a controller can sense light reflected through the fibers from the reference pattern. The controller can calculate or estimate various attributes of the prostate based on the reflected light, such as the palpable surface width or volume.

Abstract: A medical observation system, which includes a medical probe that observes a subject by scanning on the subject with laser light; a laser source that supplies the laser light to the medical probe; a judgment unit that judges whether the medical probe is in a predetermined state; and a control unit that controls an amount of laser light emitted from the laser source based on a judgment result by the judgment unit.

Abstract: Systems and methods that facilitate analysis of superficial tissue based at least in part on a depth-selective fiber optic probe are discussed herein. The depth-selective fiber optic probe can include an illumination fiber for providing light to the superficial tissue, a collection fiber for collected reflected light, a ball lens that couples the fibers, and a protective overtube that houses the ball lens and fibers. The distances between the ball lens and fibers and between the fibers can be optimized based on several factors, such as by minimizing the illumination spot size, maximizing the overlap between the illumination and collection spots, and based on the angle between the illumination and collection beams.

Abstract: An apparatus (100), control system (150) and methods are provided for directly measuring a pressure gradient, i.e. by real-time pressure measurements, with particular application for in situ measurement of transvalvular blood pressure gradients for the aortic valve and other heart valves, using minimally-invasive techniques. The apparatus takes the form of a multi-sensor assembly, e.g. enclosed within a micro-catheter or a steerable guidewire, and comprises a plurality of optical pressure sensors (10) is arranged along a length of the distal end portion (101), for measuring pressure simultaneously at each sensor location. For example, four MOMS optical pressure sensors (10), and optionally, a flow sensor (20), are incorporated into a distal end portion (101) having a diameter of 0.89 mm or less, and preferably 0.46 mm or less.

Abstract: Apparatus (100) is provided comprising an optical micro-sensor (10) for directly measuring a fluid temperature and flow by thermoconvection, which suitable for medical applications, e.g. using minimally-invasive cardiovascular techniques. A multi-sensor apparatus (100) may take the form of a micro-catheter or steerable guidewire, equipped with a plurality of miniaturized optical sensors (10) arranged along a length of the distal end (101), each coupled via optical fibers (11) to a proximal end (102) comprising an input/output connector (112) to the control system (110), without the need for electrical connections. This enables direct measurement of blood flow, temperature and/or blood pressure simultaneously at several locations within the blood vessels or the heart, including transvalvular measurements. Preferably, the distal end portion has a diameter of 0.89 mm (0.035?) or less, and more preferably 0.46 mm (0.

Abstract: A system and method for functioning organ assessment include a sensing enabled flexible device (102) having an optical fiber configured to sense induced strain continuously over a length of the flexible device. The flexible device includes a manipulation mechanism (105) configured to permit engagement with an interior wall of an organ over the length. An interpretation module (115) is configured to receive optical signals from the optical fiber between two phases of movement of the organ while the organ is functioning and to interpret the optical signals to quantify parameters associated with the functioning of the organ.

Abstract: The present invention relates to a medical probe which consists of a cannula with a multilumen stylet inside. The multilumen contains at least two lumen. Both the multilumen as well as the cannula may have beveled ends. In the lumen straight optical fibers (i.e.no angle end face) are present that can be connected at the proximal end to a console. The cannula, multilumen, fiber system forming the medical probe comprises at least in one of the lumen of the multilumen more than one optical fiber. Preferably the source and detector fibers for the fluorescence detection are contained in one single lumen of the multilumen.

Abstract: A surgical imaging device and method configured to be inserted into a surgical site. The surgical imaging device includes a plurality of prongs. Each one of the prongs has an image sensor mounted thereon. The image sensors provide different image data corresponding to the surgical site, thus enabling a surgeon to view a surgical site from several different angles. The prongs may be moveable between a first position, suitable for insertion though a small surgical incision, and a second position, in which the prongs are separated from each other. In addition, the prongs may be bendable.

Abstract: Methods and systems for whole body optical imaging using localized fluorescence excitation.

Abstract: The present invention relates to the field of optical imaging and therapeutics. More particularly, embodiments of the present invention provide minimally-invasive Fiberoptic Microneedle Devices (FMDs) for light-based therapeutics, which physically penetrate tissue and deliver light directly into the target area below the skin surface (FIG. 1). A preferred embodiment of the invention is a fiberoptic microneedle device comprising: (a) one or more silica-based needles capable of guiding light and comprising a length of about 0.5-6 mm, a base having an outer diameter in the range of about 100-150 micron, and a tip having an outer diameter in the range of about 5-20 micron; (b) a support member to which the needles are secured; (c) a ferrule comprising one or more holes for each of the needles, wherein the ferrule is operably configured to provide mechanical support to each needle at all or some portion of the length of the needle.

Abstract: A needle device according to the invention comprises a hollow shaft, an elongated insert and an operating means. The hollow shaft has a first distal end portion with a bevel, the elongated insert has a second distal end portion and is movably arranged within the hollow shaft, and the operating means is shiftable between a first condition and a second condition. Furthermore, the operating means is interconnected with the elongated insert, so that the second distal end portion is located within the hollow shaft and proximally to the bevel, when the operating means is in the first condition, and that the second distal end portion is located outside the hollow shaft and distally to the bevel, when the operating means is in the second condition.

Abstract: A system, device and method include a sensing enabled device having an optical fiber configured to perform distributed sensing of temperature-induced strain. An interpretation module is configured to receive optical signals from the optical fiber within a body and interpret the optical signals to determine one or more temperatures or temperature gradients of the device.

Abstract: Medical sensor assemblies configured to provide enhanced patient comfort when worn over a period of time are provided. The medical sensor assemblies may include sensors in optical communication with one or more biodegradable light guides that facilitate the transmission of light to and from an internal tissue of the patient. The medical sensor assemblies may also include a bandage that facilitates coupling of the light guides to the sensor. Additionally or alternatively, a bandage may be positioned against an internal tissue to specifically direct the emitted light through the tissue. Such embodiments may provide enhanced light transmission between the emitter and detector of the sensors.

Abstract: A system and a method for acquiring an image of a particle flowing in a vessel, the system comprising a light source for generating an illuminating light, an imaging probe for laterally statically illuminating at least a portion of said vessel with the illuminating light, a detection unit for detecting emitted light from an illuminated portion of said particle, and a processor unit for reproducing an image of the illuminated portion of said particle from the emitted light.

Abstract: Methods are provided for detecting lipid cores underneath thin fibrous caps (LCTC) and thin-cap fibroatheromas (TCFA) in a subject in need of diagnosis for having a vulnerable plaque, a plaque at risk of disruption or thrombosis, or risk of an acute coronary syndrome, and for screening compounds for modulators of this process.

Abstract: Provided is a canal type mini-apparatus insertable in an ear for diagnosing a disease. The canal type mini-apparatus includes a canal body and a protrusion body. The canal body is insertable in an ear and includes a bio-data detection unit at an end thereof. The bio-data detection unit is configured to detect biological data from an inside of the ear for diagnosing a disease. The protrusion body is disposed at the other end of the canal body and including a data transceiving unit. The data transceiving unit is configured to control the bio-data detection unit and transmit/receive a signal to/from an analyzing device. When the canal type mini-apparatus is inserted in the ear, at least a portion of the protrusion body protrudes outward from the ear.

Abstract: A medical device is used to image a body cavity using a plurality of axially and angularly spaced imaging sensors. Each imaging sensor generates an image that is distinct from one another due to distinct fields of vision. Each image includes an overlapping zone with commonalities that are used to extrapolate a greater calibrated image.

Abstract: An exemplary system can be provided for obtaining information associated with at least one tissue. The exemplary system can include at least one waveguide first arrangement which can provide at least one first radiation to the tissue(s), and which can receive at least one optical second radiation from the at least one tissue. Further, at least one configuration can be provided that can transceive at least one electrical signal to and from at least one portion of the system. In addition, at least one computing second arrangement can be provided which may configured to obtain the information based on the second radiation and data corresponding to the electrical signal(s). The data can comprise a position of the portion(s).

Abstract: A treatment instrument includes an insertion portion and a sample collection portion, wherein the sample collection portion includes a link portion and an advancing/retracting portion and when the advancing/retracting portion is located on a most proximal end side, the advancing/retracting portion and the link portion are connected in the axial direction and thereby become parallel to the insertion portion, when the advancing/retracting portion is located on a most distal end side, a part of the advancing/retracting portion and the link portion overlap and thereby become parallel to the insertion portion, and when the advancing/retracting portion is located between a proximal end portion side and a distal end portion side, the link portion is pushed out in a direction crossing the axial direction of the insertion portion by the advancing/retracting portion and thereby projects from the insertion portion.

Abstract: An injection device with integrated imaging capability may include a hollow, tubular needle, an optical fiber disposed in parallel to the needle, a detector, a lens structure for focusing light coupled into the lens structure from the optical fiber at a focus beyond the distal end of the needle, and an imaging engine for processing a signal received from the detector via the optical fiber and the lens structure so as to generate an image of a region about the focus.

Abstract: The invention provides an intravascular catheter with an expandable member such as a balloon with an imaging device on a surface of the expandable member. The imaging device can use an optical fiber on a surface of the expandable member to image a treatment site. Since an image can be captured directly from the surface of the expandable member, an operator can examine the treatment site while positioning the expandable member. With the treatment site in view, the operator can deliver the treatment (e.g., inflate the balloon or deploy the stent) with confidence that it will be located properly.

Abstract: Intraluminal devices, especially catheters having variable flexibility elements in a midsection of the device. The devices offer improved deliverability in an intraluminal environment, especially when used in imaging and treatment catheters.

Abstract: The present invention generally relates to forward imaging devices for imaging the inside of a vessel and associated methods. The invention can involve an elongated body configured to fit within the vessel of a lumen and at least one imaging sensor located on the elongated body configured to image an object in a forward direction.

Abstract: The present invention generally relates to optical circuits for mitigating power loss in medical imaging systems and methods for using such circuits. Circuits of the invention can involve a first optical path, a second optical path, and a means for recombining an optical signal transmitted through the first and second optical paths by sequentially gating the first and second optical paths to a single output.

Abstract: The present invention generally relates to devices that include multiple sensors for measuring different characteristics inside a vessel. For example, devices of the invention may have sensors for imaging the interior of a vessel while also detecting both pressure and/or detecting flow inside the vessel.