Testing Artificially Regulated Or Assisted Heart Patents (Class 600/510)
  • Patent number: 11040208
    Abstract: An apparatus includes a relay and sampling unit, a pacing unit, a pacing detection circuit, and a processor. The relay and sampling unit receives multiple electrocardiogram (ECG) signals that are sensed by respective electrodes in a heart of a patient, and digitize a first subset of the ECG signals, and forward a second subset of the ECG signals un-digitized over analog lines. The pacing unit outputs pacing signals, which the pacing detection circuit detects and outputs a trigger in response. The processor receives the trigger and identities of ones of the electrodes via which the pacing signals are to be applied, and, in response to identifying that the electrodes, via which the pacing signals are to be applied, are currently associated with the digitized ECG signals, instructs the relay and sampling unit to switch the identified electrodes to the analog lines for transferring the pacing signals.
    Type: Grant
    Filed: December 17, 2019
    Date of Patent: June 22, 2021
    Assignee: Biosense Webster (Israel) Ltd.
    Inventors: Assaf Govari, Vadim Gliner, Alon Boumendil, Ilya Sitnitsky
  • Patent number: 11026618
    Abstract: A system for providing information about a patient's heart, the system including one or more catheters that receive intracardiac signals from electrical activity of the heart over one or more heart beat cycles and an electronic processor coupled to the one or more catheters. The electronic processor to: receive the intracardiac signals from the one or more catheters; preprocess the intracardiac signals to provide preprocessed signals, wherein each of the intracardiac signals is preprocessed to provide a corresponding preprocessed signal; and compare the preprocessed signals to a set of signals to determine a degree of similarity between each of the preprocessed signals and the set of signals.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: June 8, 2021
    Assignee: Boston Scientific Scimed Inc.
    Inventors: Brian Stewart, Doron Harlev, Nathan H. Bennett
  • Patent number: 11020038
    Abstract: In situations in which an implantable medical device (e.g., a subcutaneous ICD) is co-implanted with a leadless pacing device (LPD), it may be important that the subcutaneous ICD knows when the LPD is delivering pacing, such as anti-tachycardia pacing (ATP). Techniques are described herein for detecting, with the ICD and based on the sensed electrical signal, pacing pulses and adjusting operation to account for the detected pulses, e.g., blanking the sensed electrical signal or modifying a tachyarrhythmia detection algorithm. In one example, the ICD includes a first pace pulse detector configured to obtain a sensed electrical signal and analyze the sensed electrical signal to detect a first type of pulses having a first set of characteristics and a second pace pulse detector configured to obtain the sensed electrical signal and analyze the sensed electrical signal to detect a second type of pulses having a second set of characteristics.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: June 1, 2021
    Assignee: Medtronic, Inc.
    Inventors: James D. Reinke, Xusheng Zhang, Vinod Sharma, Vladimir P. Nikolski, Michael B. Terry, Scott A. Hareland, Daniel L. Hansen, Donna M. Salmi
  • Patent number: 11020426
    Abstract: Described herein are low sodium formulations. In some embodiments, the low sodium formulations can contain an effective concentration of sodium and an effective concentration of calcium. The low sodium formulations can be provided as combination kit that can include, in some embodiments, a low sodium formulation and a defibrillation device. Also described herein are methods of administering the low sodium formulation to a subject in need thereof and performing cardiac resuscitation and/or defibrillation on the subject in need thereof.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: June 1, 2021
    Assignee: VIRGINIA TECH INTELLECTUAL PROPERTIES, INC.
    Inventors: Steven Poelzing, David Ryan King
  • Patent number: 10993665
    Abstract: Embodiments of neural interfaces according to the present invention comprise sensor modules for sensing environmental attributes beyond the natural sensory capability of a subject, and communicating the attributes wirelessly to an external (ex-vivo) portable module attached to the subject. The ex-vivo module encodes and communicates the attributes via a transcutaneous inductively coupled link to an internal (in-vivo) module implanted within the subject. The in-vivo module converts the attribute information into electrical neural stimuli that are delivered to a peripheral nerve bundle within the subject, via an implanted electrode. Methods and apparatus according to the invention incorporate implantable batteries to power the in-vivo module allowing for transcutaneous bidirectional communication of low voltage (e.g. on the order of 5 volts) encoded signals as stimuli commands and neural responses, in a robust, low-error rate, communication channel with minimal effects to the subjects' skin.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: May 4, 2021
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Stephen P. Buerger, Kenneth E. Wojciechowski, Roy H. Olsson, Deepesh K. Kholwadwala, David K. Novick
  • Patent number: 10926096
    Abstract: A temporary cardiac pacemaker including an acquisition module for acquiring an intracavity electrocardiography signal; a pre-processing module, connected to the acquisition module, for pre-processing the intracavity electrocardiography signal; a storage module, connected to the pre-processing module, for storing the pre-processed intracavity electrocardiography signal in real time; and a display control module, connected to the storage module, for display control. The display control module includes a display and an instruction determination unit for detecting whether a pacing parameter adjustment instruction is triggered and to call and display the intracavity electrocardiography signal stored in real time on a pacing parameter adjustment interface, which displays the intracavity electrocardiography signal stored in real time and the pacing adjustment parameter on the display; and the displayed information includes intracavity electrocardiography and electrocardiography event markers.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: February 23, 2021
    Assignee: LIFETECH SCIENTIFIC (SHENZHEN) CO., LTD
    Inventors: Xiaonan Shen, Lepeng Zeng
  • Patent number: 10926098
    Abstract: A wearable monitoring device is provided. The wearable monitoring device includes a garment to hold an electrode, be worn about a subject, and include an orientation circuit. The monitoring device also includes a control unit coupled to the orientation circuit capable of measuring at least one parameter associated with the orientation circuit and determine whether the electrode is positioned in the garment with the conductive surface oriented towards the subject based on the at least one parameter.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: February 23, 2021
    Assignee: ZOLL MEDICAL CORPORATION
    Inventors: Emil Oskin, Philip C Skalos, Thomas E Kaib
  • Patent number: 10874462
    Abstract: A console may receive signals from one or more components of the medical system over an input/out (I/O) interface. The console may process the received signals into one or more packets and transmit the one or more packets over a first interface. The console may identify an origin of the one or more packets. The console may monitor time intervals between the one or more packets to determine a connection status of the one or more components. The console may parse each of the one or more packets into a packet header and data and inspect the data for errors. The console may transmit an indication of the connection status and an indication of errors to a display over a second interface. The display may indicate the connection status and the presence of errors using one or more display schemes.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: December 29, 2020
    Assignee: Biosense Webster (Israel) Ltd.
    Inventors: Assaf Govari, Oleg Khudish, Andres Claudio Altmann
  • Patent number: 10828094
    Abstract: An intra-cardiac mapping system is based on locating the ports through which blood flows in or out the heart chambers. For many procedures, such as ablation to cure atrial fibrillation, locating the pulmonary veins and the mitral valve accurately allows to perform a Maze procedure. The location of the ports and valves is based on using the convective cooling effect of the blood flow. The mapping can be performed by a catheter-deployed expandable net or a scanning catheter. The same net or catheter can also perform the ablation procedure.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: November 10, 2020
    Assignee: KARDIUM INC.
    Inventors: Daniel Gelbart, Samuel Victor Lichtenstein
  • Patent number: 10820816
    Abstract: The invention provides a two-step approach to providing a BCI system. In a first step the invention provides a low-power implantable platform for amplifying and filtering the extracellular recording, performing analogue to digital conversion (ADC) and detecting action potentials in real-time, which is connected to a remote device capable of performing the processor-intensive tasks of feature extraction and spike classification, thus generating a plurality of predetermined templates for each neuron to be used in a second processing step. In the second step the low-power implantable platform amplifies and filters the extracellular recording, performs ADC and detects action potentials, which can be matched on-chip to the predetermined templates generated by the external receiver in the first step.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: November 3, 2020
    Assignees: UNIVERSITY OF LEICESTER, UNIVERSITY OF NEWCASTLE UPON TYNE, IP2IPO INNOVATIONS LIMITED
    Inventors: Andrew Jackson, Tim Constandinou, Amir Eftekhar, Rodrigo Quian Quiroga, Joaquin Navajas Ahumada
  • Patent number: 10806406
    Abstract: Embodiments of the present invention include systems and methods that relate to pulse oximetry. Specifically, one embodiment includes an oximeter sensor comprising a light emitting element configured to emit light, a light detector configured to detect the light, and a memory chip having a built-in trimmed resistor, the trimmed resistor having a resistance value that is detectable by a monitor.
    Type: Grant
    Filed: October 26, 2017
    Date of Patent: October 20, 2020
    Assignee: COVIDIEN LP
    Inventors: Paul D. Mannheimer, Michael E. Fein
  • Patent number: 10779737
    Abstract: Methods and apparatus to determine the presence of and track functional chronotropic incompetence (hereinafter “CI”) in an in-home setting under conditions of daily living. The functional CI of the patient may be determined with one or more of a profile of measured patient heart rates, a measured maximum patient heart rate, or a peak of the heart rate profile. The functional CI of the patient may be determined with the measured heart rate profile, in which the measured heart rate profile may correspond to heart rates substantially less than the maximum heart rate of the patient, such that the heart rate can be safely measured when the patient is remote from a health care provider. The functional CI of the patient may be determined based a peak of the remotely measured heart rate profile, for example a peak corresponding to the mode of the heart rate distribution profile.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: September 22, 2020
    Assignee: Medtronic Monitoring, Inc.
    Inventors: Rodolphe Katra, Niranjan Chakravarthy, Imad Libbus
  • Patent number: 10725559
    Abstract: The present invention provides devices, methods and systems for use with interactive equipment in a simulated or augmented environment, or in real world operations. The inventive devices, methods and systems allow for interactive operation equipment in a virtual or augmented reality environment while eliminating virtual drift of the operational equipment. The present invention further eliminates the need to reset a simulated environment to accommodate swapping out equipment, allowing a seamless simulation to provide an optimal virtual training environment. Finally, the present invention provides for a highly accurate operational equipment to be used in a virtual or augmented environment allowing for optimal training, while minimizing down time.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: July 28, 2020
    Assignee: Serious Simulations, LLC
    Inventor: Christopher M. Chambers
  • Patent number: 10688305
    Abstract: Systems, apparatus, and methods for ablation therapy are described herein, with a processor for confirming pacing capture or detecting ectopic beats. An apparatus includes a processor for receiving cardiac signal data captured by a set of electrodes, extracting a sliding window of the cardiac signal data, identifying a peak frequency over a subrange of frequencies associated with the extracted sliding window, detecting ectopic activity based at least on a measure of the peak frequency over the subrange of frequencies, in response to detecting ectopic activity, sending an indication of ectopic activity to a signal generator configured to generate pulsed waveforms for cardiac ablation such that the signal generator is deactivated or switched off from generating the pulsed waveforms. An apparatus can further include a processor for confirming pacing capture of the set of pacing pulses based on cardiac signal data.
    Type: Grant
    Filed: January 13, 2020
    Date of Patent: June 23, 2020
    Assignee: Farapulse, Inc.
    Inventor: Raju Viswanathan
  • Patent number: 10686878
    Abstract: Methods and systems are provided to manage display of cardiac signals. The methods and systems receive a first data steam along a first communications path conveyed with first throughput and receiving a second data stream along a second communications path transmitted with second throughput. The first and second throughputs are asynchronous with respect to one another. The first and second data streams carry cardiac signals sensed by external and implanted electrodes, respectively, for one or more common events. The methods and systems store data from the first and second data streams in first and second memory buffers. The methods and systems synchronize the data stored in the first and second memory buffers with one another by performing at least one of: temporally offsetting activation of the storing operation for the first and second data streams with respect to one another; or managing an amount of the data maintained in at least one of the first memory buffer or the second memory buffer.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: June 16, 2020
    Assignee: Pacesetter, Inc.
    Inventors: Muthuvale Shanmugam, Pulkit Bisen, Chao-Wen Young, Yongjian Wu, Lisbet Miller, Xing Pei, Reza Shahandeh
  • Patent number: 10653323
    Abstract: Embodiments provide a wearable device and a method for monitoring a person wearing the wearable device. The wearable device includes sensors configured to generate signal of the person, data transmission component, data analysis device, monitoring device, and positioning components. The data transmission component receives and transmits the signal to the data analysis device. The data analysis device generates a pattern of the person based on the signal, then compares the pattern with one or more predetermined normal patterns of the person. When determining that the person is functioning abnormally, the data analysis device generates and transmits the alert instruction to a monitoring device to generate a notification for notifying a care-giver that the person is functioning abnormally. The positioning components provide location information of the wearable device so that the care-giver can locate the person.
    Type: Grant
    Filed: June 21, 2019
    Date of Patent: May 19, 2020
    Assignee: Thunder Power New Energy Vehicle Development Company Limited
    Inventor: Fuchia Yang
  • Patent number: 10638974
    Abstract: Embodiments provide a wearable device and a method for monitoring a person wearing the wearable device. The wearable device includes sensors configured to generate signal of the person, data transmission component, data analysis device, monitoring device, and positioning components. The data transmission component receives and transmits the signal to the data analysis device. The data analysis device generates a pattern of the person based on the signal, then compares the pattern with one or more predetermined normal patterns of the person. When determining that the person is functioning abnormally, the data analysis device generates and transmits the alert instruction to a monitoring device to generate a notification for notifying a care-giver that the person is functioning abnormally. The positioning components provide location information of the wearable device so that the care-giver can locate the person.
    Type: Grant
    Filed: December 13, 2018
    Date of Patent: May 5, 2020
    Inventor: Fuchia Yang
  • Patent number: 10569005
    Abstract: A monitoring device detects a disruption of a fluid connection between first and second fluid containing systems using one or more pressure sensors arranged in the first fluid containing system to detect first pulses from the first fluid containing system and second pulses from the second fluid containing system. The monitoring device receives (501) pressure signal(s) from the pressure sensor(s), populates (504) signal vectors by signal segments in the pressure signal(s) and computes (505) one or more eigenvectors and/or one or more eigenvalues for the signal vectors by a source separation algorithm. The monitoring device detects (506) the disruption based on a monitoring parameter, which is computed as a function of the eigenvector(s) and/or eigenvalue(s) to be responsive to the second pulses in the pressure signal(s). The monitoring device may be associated with or included in an apparatus for extracorporeal blood processing, such as a dialysis machine.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: February 25, 2020
    Assignee: Gambro Lundia AB
    Inventors: Kristian Solem, Bo Olde
  • Patent number: 10561853
    Abstract: A defibrillator (AED) and method for using a defibrillator using two different ECG analysis algorithms which work sequentially to improve the accuracy of AED shock decisions. A first algorithm, such as (ART), is particularly suited for analysis in the presence of CPR periods. A second algorithm, such as (PAS), is particularly suited for analysis during hands-off periods. The AED switches algorithms depending on the period and on the current analysis of the cardiac rhythm. The inventions thus provide an optimized ECG analysis scheme in a manner that improves the effectiveness of the rescue, resulting in more CPR “hands-on” time, better treatment of refibrillation, and reduced transition times between CPR and electrotherapy.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: February 18, 2020
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Chenguang Liu, Stacy Earl Gehman, James Knox Russell, Christopher William Fleming, Dawn Blilie Jorgenson, David Roy Axness, Jeffrey Martin Boschee
  • Patent number: 10507358
    Abstract: A method, apparatus, and a computer program for monitoring a fitness exercise are described. A plurality of heart-rate variability values and a plurality of exertion parameter values are measured during an exercise measured. The heart rate variability values correlate with the exertion parameter values through a human physiological mechanism, and the exertion parameter values characterize the physical exertion of the exercise. A mathematical correspondence is then constructed from the plurality of measured heart rate variability values and associated exertion parameter values. The mathematical correspondence describes correlation between the heart rate variability values and the exertion parameter values and the user's physiological state during the exercise. Then, the physical exertion of the exercise is monitored by applying the mathematical correspondence.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: December 17, 2019
    Assignee: POLAR ELECTRO OY
    Inventors: Hannu Kinnunen, Jarkko Haataja, Tero Posio
  • Patent number: 10496732
    Abstract: A method for generating and displaying a user-customized page and a mobile device thereof are provided. The method for processing a user-customized page in a mobile device includes collecting use information of a user with respect to the mobile device when a preset specific situation occurs, generating a user-customized page associated with the specific situation using the use information when the specific situation is terminated, and storing the generated user-customized page.
    Type: Grant
    Filed: August 26, 2013
    Date of Patent: December 3, 2019
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Chihoon Lee, Sanghyuk Koh, Taeyeon Kim, Jihye Myung, Hyunmi Park, Hyemi Lee
  • Patent number: 10471261
    Abstract: A connector block that permits simultaneous and continuous interconnection of the three leads of the epicardial pacing wires, the pacemaker, and the ECG monitor on clear separately labeled connectors is provided. Circuitry is provided that allows the display of epicardial signals on the telemetry unit, while still preserving the ability to pace the heart from the pacemaker. When pacing the connector block prevents excessive loading of the pacer signals by the ECG monitor and/or damage to the monitor by the high-voltage pacer signals. The connector block may be used universally on all monitors without the need for sophisticated understanding of the electrical characteristics of the ECG monitor or concern for damage or improper signal loading.
    Type: Grant
    Filed: August 5, 2016
    Date of Patent: November 12, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Nicholas Von Bergen, Philip Terrien, Matthew Knoespel, Connor Sheedy, James Olson, Randal Mills
  • Patent number: 10456057
    Abstract: A signal processing evaluator and methods that compare a digital waveform of a cardiac signal to a first processed signal generated by a test system such as an EP recorder or an EP mapping system and generates a first finding evaluating how well the test system filters non-cardiac signals or simulated body impedance. A simulator and methods that send cardiac signals including non-cardiac signals or simulated body impedance to a test system and to a signal processing evaluator for evaluation of the test system.
    Type: Grant
    Filed: December 12, 2014
    Date of Patent: October 29, 2019
    Assignee: BIOSIG TECHNOLOGIES, INC.
    Inventors: Budimir S. Drakulic, Thomas George Foxall, Sina Fakhar, Branislav Vlajinic
  • Patent number: 10451701
    Abstract: With an MRI apparatus using a transmission coil having multiple channels, a region desired to be diagnosed is efficiently imaged with high image quality. The MRI apparatus comprises a region setting means for setting a region in an imaging region, of which high quality image is desired to be obtained, as a first region, and an optimization means for determining at least one of amplitude and phase of a radio frequency wave transmitted to each of the multiple channels as a radio frequency magnetic field condition, and the optimization means determines the radio frequency magnetic field condition so that at least one of specific absorption ratio and signal value of a region that generates artifacts is not higher than a predetermined value defined for each, under a uniformity constraint condition that uniformity of radio frequency magnetic field distribution in the first region is not lower than a predetermined value.
    Type: Grant
    Filed: July 24, 2013
    Date of Patent: October 22, 2019
    Assignee: HITACHI, LTD.
    Inventors: Yukio Kaneko, Hideta Habara, Yoshihisa Soutome, Yoshitaka Bito
  • Patent number: 10406373
    Abstract: An extra-cardiovascular implantable cardioverter defibrillator is configured to store a cardiac signal segment in response to sensing a cardiac event and obtain a notch filtered signal segment by notch filtering the cardiac signal segment. The ICD determines a count of crossings of the notch filtered signal segment by the cardiac signal segment and determines whether electromagnetic interference (EMI) is present in the cardiac signal segment based on a value of the count.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: September 10, 2019
    Assignee: Medtronic, Inc.
    Inventor: Xusheng Zhang
  • Patent number: 10342981
    Abstract: A medical device system for controlling ventricular pacing therapy during cardiac resynchronization therapy that includes a sensing device to sense a cardiac signal and emit a trigger signal in response to the sensed cardiac signal, a therapy delivery device to deliver the ventricular pacing in response to the emitted trigger signal, and a processor configured to identify a fiducial point of the cardiac signal sensed in real-time, set a window comprising a start point positioned a first distance prior to the fiducial point and an endpoint positioned a second distance less than the first distance subsequent to the fiducial point, determine a signal characteristic of the cardiac signal within the window, determine whether a P-wave is detected in response to the signal characteristic, determine whether an atrio-ventricular interval timer has expired, and emit a trigger signal to deliver the ventricular pacing timed off of the local maximum in response to the P-wave being detected and not timed off of the local m
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: July 9, 2019
    Assignee: Medtronic, Inc.
    Inventors: Subham Ghosh, Kushagr Gupta
  • Patent number: 10300284
    Abstract: Systems and methods are provided for delivering neurostimulation therapies to patients for treating chronic heart failure. A neural fulcrum zone is identified and ongoing neurostimulation therapy is delivered within the neural fulcrum zone. This neural fulcrum zone corresponds to a combination of stimulation parameters at which autonomic engagement is achieved, while the tachycardia-inducing stimulation effects are offset by the bradycardia-inducing effects, thereby minimizing side effects such as significant heart rate changes while providing a therapeutic level of stimulation.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: May 28, 2019
    Assignees: LivaNova USA, Inc., East Tennessee State University
    Inventors: Bruce H. KenKnight, Jeffrey L. Ardell, Imad Libbus, Badri Amurthur
  • Patent number: 10258250
    Abstract: The present disclosure provides a GPU-based parallel electrocardiogram signal analysis method, comprising: performing a filtering process of electrocardiogram signals through a long interval artifact removal and a short interval artifact removal; performing a QRS detection of the filtering-processed electrocardiogram signals through an R-wave position extraction, a QRS complex start and end positions extraction and a QRS complex width extraction; performing an abnormal waveform classification of the QRS-detected electrocardiogram signals through template creation; wherein at least one of the long interval artifact removal, the short interval artifact removal, the R-wave position extraction, the QRS complex width extraction and the creation template is performed by a multiple threads at a GPU device side in parallel, any thread being read through its unique index number to process corresponding data.
    Type: Grant
    Filed: December 23, 2016
    Date of Patent: April 16, 2019
    Assignee: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES
    Inventors: Ye Li, Xiaomao Fan, Furu Xiang, Yunpeng Cai, Fen Miao
  • Patent number: 10244958
    Abstract: A cardiac function measurement and evaluation device is provided to measure and evaluate cardiac function in patients with atrial fibrillation, sinus arrhythmia, and the like, using thoracic impedance data and electrocardiogram data. By creating a two-dimensional scatter plot in which (dZ/dt)min values and preceding RR intervals (RR1) corresponding thereto, and the like obtained by thoracic impedance measurement, are plotted, it is possible to visually and easily evaluate the state of cardiac function in patients with atrial fibrillation and sinus arrhythmia. Using the measurement and evaluation device of the present invention makes it possible to perform examinations easily and repeatedly with less burden on patients. Therefore, it is possible to provide very useful information for diagnosing heart disease, selecting drugs, and the like.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: April 2, 2019
    Assignee: MEDICAL CORPORATION USHIRODA INTERNAL MEDICINE CLINIC
    Inventor: Shinichi Ushiroda
  • Patent number: 10207112
    Abstract: Methods of nerve signal differentiation, methods of delivering therapy using such nerve signal differentiation, and to systems and devices for performing such methods. Nerve signal differentiation may include locating two electrodes proximate nerve tissue and differentiating between efferent and afferent components of nerve signals monitored using the two electrodes.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: February 19, 2019
    Assignee: MEDTRONIC, INC.
    Inventors: Xiaohong Zhou, Lilian Kornet, Richard N. M. Cornelussen, Robert W. Stadler
  • Patent number: 10207118
    Abstract: The disclosure describes techniques for associating therapy adjustments with posture states using a timer. The techniques may include detecting a patient adjustment to electrical stimulation therapy delivered to the patient, sensing a posture state of the patient, and associating the detected adjustment with the sensed posture state if the sensed posture state is sensed within a first period following the detection of the adjustment and if the sensed posture state does not change during a second period following the sensing of the sensed posture state.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: February 19, 2019
    Assignee: Medtronic, Inc.
    Inventor: Dennis M. Skelton
  • Patent number: 10194820
    Abstract: A cardiac rhythm management system senses a cardiac signal indicative of heartbeats and an acoustic signal indicative of heart sounds and detects atrial tachyarrhythmia based on the sensed cardiac and acoustic signals. In various embodiments, the system senses the cardiac and acoustic signals without using an atrial lead, thus allowing for, for example, monitoring atrial fibrillation burden in a heart failure patient who does not wear an implantable device with an atrial lead. In various embodiments, the system detects heartbeats and heart sounds, measures parameters associated with the detected heartbeats and heart sounds, and detects one or more specified types of atrial tachyarrhythmia using the measured parameters. In various embodiments, the measured parameters are selected from heart rate, heart sound amplitude, cycle length variability, and systolic and diastolic intervals.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: February 5, 2019
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Pramodsingh Hirasingh Thakur, Qi An, Barun Maskara
  • Patent number: 10136860
    Abstract: A system for assessing risk associated with a suspected heart rhythm disorder includes at least one sensor for generating a signal received from a beating human heart over a plurality of time segments, and an analytic engine that receives the signal and calculates a change in the signal among at least a first time segment and a second time segment in response to a change in at least one of rate and regularity induced in the beating human heart. The analytic engine generates a risk score for the heart rhythm disorder based at least in part on the change in the signal. The system may further be configured to control modification of tissue of the beating human heart based on the risk score.
    Type: Grant
    Filed: June 27, 2016
    Date of Patent: November 27, 2018
    Assignees: The Regents of the University of California, The United States of America as Represented by the Department of Veterans Affairs
    Inventor: Sanjiv Narayan
  • Patent number: 10129767
    Abstract: A method for collecting diagnostic data in a wireless communication network. The method comprises storing previously measured results of the diagnostic data for improving quality of the wireless communication network, determining a spatiotemporal correlation model based on the previously measured results of the diagnostic data in accordance with a data collection strategy, and collecting new diagnostic data based on the determined spatiotemporal correlation model and the data collection strategy.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: November 13, 2018
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Yu Wang, Pei Zheng
  • Patent number: 10010716
    Abstract: An implantable medical system includes an implantable medical lead including at least one electrode and an implantable medical device (IMD) coupled to the implantable medical lead. The IMD includes a sensing module that obtains electrical signals on the implantable medical lead. The electrical signals on the implantable medical lead include cardiac signals as well as noise-induced signals. The IMD also includes a noise detection module that obtains noise signals independently of the electrical signals on the implantable medical lead. A control module of the IMD adjusts a sensing threshold of the sensing module in response to detecting the noise signals via the noise detection module. In instances in which the amplitude of the noise-induced signal on the lead is too large, the IMD may transition to a noise operating mode specifically designed to accommodate noisy environments.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: July 3, 2018
    Assignee: Medtronic, Inc.
    Inventors: Michael L. Ellingson, Patrick L. Parish, Hyun J. Yoon
  • Patent number: 10004414
    Abstract: A method for detecting a stimulus pulse by using two or more electrical signals derived from a living body, the method comprising the following steps: (a) for each electrical signal, digitizing the signal with an analog-to-digital converter to produce a sampled signal Sk; (b) for each signal Sk at a sample time ti, computing a primary difference ?kp(ti)=abs[Sk(ti)?Sk(ti?p)]; (c) determining the minimum value of all of the computed differences, such minimum being a detector output D(ti); (d) comparing the detector output D(ti) with a detection threshold; and (e) indicating that a stimulus pulse has been detected when the detector output D(ti) is above the detection threshold.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: June 26, 2018
    Assignee: APN Health, LLC
    Inventor: Donald Brodnick
  • Patent number: 9993205
    Abstract: Methods and devices for classifying a cardiac response to pacing involve establishing a retriggerable cardiac response classification window. A first cardiac response classification window is established subsequent to delivery of a pacing pulse. A cardiac signal following the pacing stimulation is sensed in the first classification window. A second cardiac response classification may be triggered if a trigger characteristic is detected in the first classification window. The cardiac signal is sensed in the second classification window if the second classification window is established. The cardiac response to the pacing stimulation is determined based on characteristics of the cardiac signal. The cardiac response may be determined to be one of a captured response, a non-captured response, a non-captured response added to an intrinsic beat, and a fusion/pseudofusion beat, for example.
    Type: Grant
    Filed: June 17, 2010
    Date of Patent: June 12, 2018
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Scott A. Meyer, Yanting Dong, Jeremy Maniak, Doug Birholz, John Voegele
  • Patent number: 9968267
    Abstract: An apparatus includes a computing device that includes a memory configured to store instructions. The computing device also includes a processor to execute the instructions to perform operations that include receiving a signal representative of electrical impedance in a chest of a patient, and, receiving a signal representative of the motion of chest compressions performed on the patient during a cardiopulmonary resuscitation (CPR) treatment. The operations also include processing the received signal representative of the motion of chest compressions to determine one or more characteristics of the motion, and, processing the received signal representative of the electrical impedance to determine parameters relevant to a production of a signal representative of airflow activities of the patient. Operations also include modifying the one or more determined parameters based on the one or more determined characteristics of the motion to produce the signal representative of airflow activities of the patient.
    Type: Grant
    Filed: March 7, 2014
    Date of Patent: May 15, 2018
    Assignee: ZOLL Medical Corporation
    Inventors: Frederick J. Geheb, Gary A. Freeman, Ulrich Herken
  • Patent number: 9937347
    Abstract: Example apparatus and methods plan and control neuro-modulation of a distributed multi-region network in a brain. A location for a deep brain stimulation (DBS) electrode that participates in activating a combination of white matter pathways associated with the network is selected. The location is selected based on a pre-implantation image of the brain and a probabilistic activation model of the network. An initial stimulation parameter for DBS to be applied through the DBS electrode is selected based on a post-implantation image of the brain and the probabilistic activation model of the network. A modified stimulation parameter for DBS being applied through the DBS electrode is selected based on the initial stimulation parameter, a local field potential measured in the distributed multi-region network in response to DBS applied using the initial stimulation parameter, the probabilistic activation model of the distributed multi-region network, and the post-implantation image of the brain.
    Type: Grant
    Filed: December 1, 2014
    Date of Patent: April 10, 2018
    Assignee: Case Western Reserve University
    Inventors: Cameron McIntyre, Patricio Riva-Posse, Ki Sueng Choi, Ashutosh Chaturvedi, Helen Mayberg, Michele Tagliati, Tyler Cheung
  • Patent number: 9901267
    Abstract: A cardiopulmonary function evaluating apparatus includes: an electrocardiogram measuring unit which is configured to measure an electrocardiogram of a subject; a photoplethysmogram detecting unit which is configured to detect a photoplethysmogram of the subject; a heart rate calculating unit which is configured to calculate a heart rate (HR) of the subject based on the electrocardiogram; a PWTT calculating unit which is configured to calculate a pulse wave transmission time (PWTT) of the subject based on the electrocardiogram and the photoplethysmogram; an SV calculating unit which is configured to calculate a stroke volume (SV) of the subject based on the heart rate and the pulse wave transmission time; and an outputting unit which is configured to output a state related to the stroke volume of the subject based on the stroke volume that is calculated by the SV calculating unit.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: February 27, 2018
    Assignee: NIHON KOHDEN CORPORATION
    Inventors: Norihito Konno, Makoto Hajiri
  • Patent number: 9820667
    Abstract: There is a method and system for detecting heartbeat irregularities comprising the steps of receiving a dataset representative of at least one waveform, the at least one waveform indicative of a subject's heart activity over a predetermined period of time; identifying from the data representative of at least one waveform, a plurality of peaks, each peak corresponding to a heartbeat; identifying from the predetermined period of time the time occurrence of each peak; calculating the difference (duration) between the time occurrence of each peak with its adjacent peak; determining the difference between each duration; classifying the absolute value of the difference into one of at least three intermediate categories; wherein each intermediate category comprises a specified range such that the absolute value is categorized into the intermediate category if it falls between the range; the intermediate categories further providing an indication of whether the subject has heartbeat irregularity.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: November 21, 2017
    Assignee: HEALTHSTATS INTERNATIONAL PTE LTD
    Inventors: Choon Meng Ting, Wei Nee Serene Chang
  • Patent number: 9782101
    Abstract: There is a method and system for detecting heartbeat irregularities comprising the steps of receiving a dataset representative of at least one waveform, the at least one waveform indicative of a subject's heart activity over a predetermined period of time; identifying from the data representative of at least one waveform, a plurality of peaks, each peak corresponding to a heartbeat; identifying from the predetermined period of time the time occurrence of each peak; calculating the difference (duration) between the time occurrence of each peak with its adjacent peak; determining the difference between each duration; classifying the absolute value of the difference into one of at least three intermediate categories; wherein each intermediate category comprises a specified range such that the absolute value is categorized into the intermediate category if it falls between the range; the intermediate categories further providing an indication of whether the subject has heartbeat irregularity.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: October 10, 2017
    Assignee: HEALTHSTATS INTERNATIONAL PTE LTD
    Inventors: Choon Meng Ting, Wei Nee Serene Chang
  • Patent number: 9750416
    Abstract: Systems and methods provide for ambulatorily sensing pulmonary artery pressure from within a patient, and producing a pulmonary artery pressure measurement from the sensed pulmonary artery pressure. Power is ambulatorily provided within the patient to facilitate sensing of the pulmonary artery pressure and producing of the pulmonary artery pressure measurement. Acute pulmonary embolism is detected based on a change or rate of change in the pulmonary artery pressure measurement. An alert is preferably generated in response to detecting pulmonary embolism.
    Type: Grant
    Filed: April 3, 2012
    Date of Patent: September 5, 2017
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: Wangcai Liao, Jeffrey Stahmann, Bin Mi, Yunlong Zhang
  • Patent number: 9731137
    Abstract: The current technology is relevant to a system having a programming device capable of communication with an implantable medical device, where the programming device is configured to identify a patient condition comprising the patient's inability to exercise to a desired capacity, configured to notify a clinical user of the identified condition and configured to identify a therapy appropriate for the identified condition.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: August 15, 2017
    Assignee: Cardiac Pacemakers, Inc.
    Inventors: James O. Gilkerson, Kenneth P. Hoyme, James R. Kalgren, David L. Perschbacher, Les N. Peterson
  • Patent number: 9724000
    Abstract: The present disclosure provides an exercise guiding system including a sensing module, a calculating module, a converting module and an output module. The sensing module keeps recording an R-R interval of a user doing exercise. The computing module receives the R-R interval from the sensing module and performs heart rate variability analysis on the R-R interval to generate a first output. The converting module receives the first output from the calculating module, recognizes a threshold output of the first output according to a threshold and acquires an anaerobic threshold corresponding to the user according to the threshold output, wherein the anaerobic threshold corresponding to the user is a first heart rate corresponding to the threshold output in the R-R interval. The output module receives the anaerobic threshold from the converting module and outputs an exercise guidance of the user according to the anaerobic threshold.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: August 8, 2017
    Assignee: Industrial Technology Research Institute
    Inventors: Rong-Rong Chen, Yueh-Hsuan Lee, Tung-Hung Lu, Jong-Shyan Wang, Hsing-Hua Tsai
  • Patent number: 9717428
    Abstract: Devices and methods provide for the sensing of physiological signals during stimulation therapy by preventing stimulation waveform artifacts from being passed through to the amplification of the sensed physiological signal. Thus, the sensing amplifier is not adversely affected by the stimulation waveform and can provide for successful sensing of physiological signals. A common mode voltage is applied to the stimulation electrodes while sensing during a recharge period where the common mode voltage approximates the stimulation pulse being received at the sensing electrodes. This common mode voltage is determined based on measuring a common mode signal for at least one of the inputs of the amplifier or by deriving the proper common mode from monitoring the output signal of the amplifier to observe the elimination of artifacts during stimulation. Blanking switches may be used to blank the sensing of the peak of the recharge period should that peak be relatively large.
    Type: Grant
    Filed: February 7, 2014
    Date of Patent: August 1, 2017
    Assignee: MEDTRONIC, INC.
    Inventors: Peng Cong, Timothy J. Denison, Forrest C. M. Pape, Wesley A. Santa, Jalpa S. Shah, Scott R. Stanslaski
  • Patent number: 9687667
    Abstract: A magnetic switching device includes an electromagnet adapted to be arranged proximate to an exterior surface of an object having a magnetically-switchable device therein and a control circuit electrically connected to the electromagnet. The electromagnet is constructed to generate a magnetic field of sufficient strength and orientation to engage a switch in the magnetically-switchable device. The invention further includes an electrocautery system, including an electrocautery device, a control circuit electrically connected to the electrocautery device, and an electromagnet electrically connected to the control circuit. The electromagnet is adapted to be arranged proximate to an exterior surface of an object having a magnetically-switchable device therein. Operation of the electrocautery device causes the electromagnet to generate a magnetic field of sufficient strength to engage a switch in the magnetically-switchable device.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: June 27, 2017
    Assignee: CARDIAC LEAD TECHNOLOGIES, LLC
    Inventors: William Choe, Sang Won Yoon
  • Patent number: 9681815
    Abstract: The present invention relates to an active medical device that uses non-linear filtering for reconstructing a surface electrocardiogram from an endocardial electrogram. At least one endocardial EGM electrogram signal is collected from of samples collected from at least one endocardial or epicardial derivation (71?, 72?, 73?), and at least one of a reconstructed surface electrocardiogram (ECG) signal through the processing of collected EGM samples by a transfer function (TF) of a neural network (60?). The neural network (60?) is a time-delay-type network that simultaneously processes said at least one endocardial EGM electrogram signal, formed by a first sequence of collected samples, and at least one delayed version of this EGM signal, formed by a second sequence of collected samples distinct from the first sequence collected samples. The neural network (60?) provides said reconstructed ECG signal from the EGM signal and its delayed version.
    Type: Grant
    Filed: August 30, 2013
    Date of Patent: June 20, 2017
    Assignee: SORIN CRM SAS
    Inventors: Fabienne Porée, Guy Carrault, Amar Kachenoura, Alfredo Hernandez
  • Patent number: 9675799
    Abstract: The present invention relates, generally, to scientific and medical system methods for diagnosis of implantable cardioverter defibrillator (ICD) lead conductor anomalies, in particular conductor migration and externalization within an ICD implantable cardiac lead. The method uses an “imaginary” component of the high frequency transmission line impedance having certain spectral changes that correspond to movements of the conductor or an “imaginary impedance”. This allows the detection of conductor migration and small insulation failures.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: June 13, 2017
    Assignee: Lambda Nu Technology LLC
    Inventors: Mark William Kroll, Charles Dennis Swerdlow
  • Patent number: 9668659
    Abstract: Methods, devices, and processor-readable storage media are provided for the diagnosis of heart failure. One method includes collecting, using an implantable device, reference episodes; generating an in-suspicion model-cycle and an off-suspicion model-cycle based on the reference episodes; and determining whether to generate a heart failure alert, based on a difference between the in-suspicion model-cycle and the off-suspicion model-cycle.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: June 6, 2017
    Assignee: SORIN CRM SAS
    Inventors: Jérôme Dumont, Lionel Giorgis