Blood Output Per Beat Or Time Interval Patents (Class 600/526)
  • Patent number: 10617322
    Abstract: A method of calculating blood flow in an organ of a subject using output radiofrequency signals transmitted to the organ and input radiofrequency signals received from the organ, the method comprises determining a phase shift of the input radiofrequency signals relative to the output radiofrequency signals and using the phase shift to calculate the blood flow in the organ.
    Type: Grant
    Filed: February 4, 2013
    Date of Patent: April 14, 2020
    Assignee: Cheetah Medical, Inc.
    Inventors: Hanan Keren, Avram B. Simon
  • Patent number: 10605663
    Abstract: A method is provided for Fourier domain dynamic correction of optical fringes in a laser spectrometer. The method includes Fourier transforming a background spectrum contaminated with the optical fringes to obtain baseline fringes in a frequency domain. The method includes partitioning the baseline fringes in the frequency domain using bandpass filtering to obtain partitioned baseline fringes. The method includes reconstructing the partitioned baseline fringes as separate spectra using an inverse Fourier transform. The method includes constructing a fitting model to approximate the background spectrum by assigning a first and a second free parameter to each of partitioned baseline fringe components to respectively allow for drift and amplitude adjustments during a fitting of the fitting model. The method includes applying the fitting model to a newly acquired spectrum to provide an interpretation of the newly acquired spectrum having a reduced influence of spectral contamination on concentration retrieval.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: March 31, 2020
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventors: Cheyenne Teng, Gerard Wysocki, Eric J. Zhang, William M. Green
  • Patent number: 10350385
    Abstract: A system includes an outer catheter and an inner catheter. The outer catheter has a proximal end and a distal end. The distal end has a discharge nozzle, a tapered interior wall, and an end orifice. The proximal end is configured to receive a fluid. The discharge nozzle is coupled to the proximal end by a first lumen. The discharge nozzle is configured to direct the fluid in a plurality of discrete streams aligned in a radial fashion about an axis of the first lumen. The interior catheter is configured for placement within the first lumen. A first end of the interior catheter includes an occluder and includes a first temperature sensor. The first temperature sensor is configured to pass through the end orifice. The occluder is configured to engage with the tapered interior wall in a fluid-tight seal. The first temperature sensor includes a sense surface and includes a signal node. The signal node is configured to provide a first signal corresponding to a timewise change in temperature at the sense surface.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: July 16, 2019
    Assignee: Regents of the University of Minnesota
    Inventors: Matthew D. Olson, Demetris Yannopoulos, Jason Bartos
  • Patent number: 10219720
    Abstract: Impedance devices for obtaining conductance measurements within luminal organs. In at least one embodiment of an impedance device of the present disclosure, the device, comprises an elongated body and an detector positioned upon the elongated body, the detector comprising at least five electrodes and configured to obtain one or more conductance measurements generated using a first arrangement of four of the at least five electrodes and further configured to obtain one or more fluid velocity measurements using a second arrangement of four of the at least five electrodes when the elongated body is positioned within a fluid environment of a mammalian luminal organ, wherein the first arrangement is different from the second arrangement.
    Type: Grant
    Filed: November 11, 2014
    Date of Patent: March 5, 2019
    Assignee: 3DT Holdings, LLC
    Inventor: Ghassan S. Kassab
  • Patent number: 10155115
    Abstract: A method and system for treating cardiac arrhythmias which includes inserting one or more electrodes into a patient's neck, and connecting the electrodes to the vagus nerve in the patient's neck. A cardiac monitoring device detects a cardiac arrhythmia. A controller connected to an electrical power source provides electrical power to the electrodes to apply electrical stimulation to the vagus nerve when a cardiac arrhythmia is detected.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: December 18, 2018
    Assignee: The Research Foundation for The State University of New York
    Inventors: Mark Stewart, Isaac Naggar, Jason Lazar
  • Patent number: 10058251
    Abstract: The present disclosure concerns a method for determining a heart-lung interaction factor of a subject, comprising: measuring a heart activity-related signal comprising heart activity-related information; from the heart activity-related signal, calculating a frequency of cardiac cycle and a frequency of respiratory cycle; from the heart activity-related signal, determining a cardiac cycle energy at the frequency of cardiac cycle, determining a respiratory cycle energy at the frequency of respiratory cycle, and determining a heart-lung interaction energy at an intermodulation frequency corresponding to the difference between the frequency of respiratory cycle and the frequency of cardiac cycle, or the sum of the frequency of respiratory cycle and the frequency of cardiac cycle; and determining a heart-lung interaction factor from the ratio of the heart-lung interaction energy and one of the cardiac cycle energy and the respiratory cycle energy. The heart-lung interaction factor can be determined non-invasively.
    Type: Grant
    Filed: May 2, 2012
    Date of Patent: August 28, 2018
    Assignee: CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA—RECHERCHE ET DÉVELOPPEMENT
    Inventors: Josep Sola i Caros, Josef X. Brunner
  • Patent number: 9999397
    Abstract: A biosignal processing apparatus and method thereof include a signal receiver and a signal processor. The signal receiver is configured to receive a biosignal having a corresponding electrical physical quantity from a sensor. The signal processor includes a voltage inputter and a current inputter, and configured to process the biosignal using one of the voltage inputter and the current inputter and based on the corresponding electrical physical quantity of the biosignal.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: June 19, 2018
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: TakHyung Lee, JongPal Kim
  • Patent number: 9724516
    Abstract: A method and system for treating cardiac arrhythmias which includes inserting one or more electrodes into a patient's neck, and connecting the electrodes to the vagus nerve in the patient's neck. A cardiac monitoring device detects a cardiac arrhythmia. A controller connected to an electrical power source provides electrical power to the electrodes to apply electrical stimulation to the vagus nerve when a cardiac arrhythmia is detected.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: August 8, 2017
    Assignee: The Research Foundation for The State University of New York
    Inventors: Mark Stewart, Isaac Naggar, Jason Lazar
  • Patent number: 9610118
    Abstract: A method and apparatus for mapping a location of a point within the body is disclosed. A plurality of positional reference nodes are determined, each aligned on a first element. A second element is mapped with reference to the plurality of reference nodes to determine the relative location of a point on the second element.
    Type: Grant
    Filed: December 31, 2008
    Date of Patent: April 4, 2017
    Assignee: St. Jude Medical, Atrial Fibrillation Division, Inc.
    Inventor: Eric S. Olson
  • Patent number: 9591976
    Abstract: Method for measuring a blood volume is provided. At least two types of respiratory variation data; for instance, data pertinent to respiratory variations in stroke volume (SVV) data, data pertinent to respiratory variations in an amplitude of a pulse wave (PAV), a pulse wave transit time (PWTT) in a respiratory cycle, and a heart rate (HR) in a predetermined time, are measured, and patient's inherent coefficients ?, ?, and K are calculated, whereby a cardiac output can be determined by an equation CO=K (?*PWTT+?)*HR.
    Type: Grant
    Filed: October 22, 2013
    Date of Patent: March 14, 2017
    Assignee: NIHON KOHDEN CORPORATION
    Inventors: Yoshihiro Sugo, Tomoyuki Sakai, Mami Terao
  • Patent number: 9415188
    Abstract: A system and method for guiding a catheter or other medical device to a desired target destination within the vasculature of a patient via bioimpedance measurements is disclosed. The target destination in one embodiment includes placement of the catheter such that a distal tip thereof is disposed proximate the heart, e.g., the junction of the right atrium and superior vena cava. In one embodiment the method for guiding the catheter comprises introducing the catheter into a vessel of the patient, the catheter defining a lumen through which fluids can be infused into the vasculature of the patient. The catheter is advanced toward a target destination within the vasculature. A first impedance value based on intravascular detection of at least one electrical property related to a first tissue surface of the vessel is calculated to enable determination of the proximity of a distal end of the catheter to the target destination.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: August 16, 2016
    Assignee: C. R. Bard, Inc.
    Inventors: Ding Sheng He, David J. Ciavarella, Eddie K. Burnside, Kevin W. Stinger
  • Patent number: 9357937
    Abstract: A system for determining stroke volume of an individual. The system includes a skew-determining module that is configured to calculate a first derivative of photoplethysmogram (PPG) signals of the individual. The first derivative forms a derivative waveform. The skew-determining module is configured to determine a skew metric of the first derivative, wherein the skew metric is indicative of a morphology of at least one pulse wave detected from blood flow of the individual in the derivative waveform. The system also includes an analysis module that is configured to determine a stroke volume of the individual. The stroke volume is a function of the skew metric of the first derivative.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: June 7, 2016
    Assignee: Covidien LP
    Inventors: James Nicholas Watson, Paul Stanley Addison
  • Patent number: 9339348
    Abstract: Embodiments of the present disclosure are configured to assess the severity of a blockage in a vessel and, in particular, a stenosis in a blood vessel. In some particular embodiments, the devices, systems, and methods of the present disclosure are configured to assess the severity of a stenosis in the coronary arteries without the administration of a hyperemic agent.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: May 17, 2016
    Assignees: Imperial Colege of Science, Technology and Medicine, Volcano Corporation, Medsolve Limited
    Inventors: Justin Davies, Joseph Burnett, Neil Hattangadi, David Anderson, Helen Catherine Stuart Davies
  • Patent number: 9332917
    Abstract: A method determines cardiac output or stroke volume by receiving signal data representing multiple parameters of a patient concurrently acquired over a particular time period and comprising at least one of, (a) a parameter derived from an ECG waveform of the patient, (b) a parameter derived from a blood pressure signal of the patient, (c) a parameter derived from signal data representing oxygen content of blood of the patient and (d) a parameter derived from a patient cardiac impedance value. A selected parameter of the multiple concurrently acquired parameters is used in calculating a heart stroke volume of the patient comprising volume of blood transferred through the blood vessel in a heart cycle, in response to, a combination of a weighted summation of values of the selected parameter over the particular time period. Data representing the calculated heart stroke volume is provided to a destination device.
    Type: Grant
    Filed: January 17, 2013
    Date of Patent: May 10, 2016
    Assignee: Siemens Medical Solutions USA, Inc.
    Inventor: Hongxuan Zhang
  • Patent number: 9326735
    Abstract: There is provided a method of determining a measure of the cardiac output, CO, of a patient, the method comprising obtaining measurements of one or more physiological characteristics of the patient, the physiological characteristics including at least the heart rate, HR, of the patient, the systolic blood pressure, S, of the patient and the diastolic blood pressure, D, of the patient; and processing the measurements to determine a measure of the cardiac output of the patient; wherein the measure of the cardiac output of the patient is derived using the relationship CO = K 1 ? ( HR ? S - D S + D ) , CO = K 2 ? HR ? ( S - D ) ? ( PTT ) 2 , and ? / ? or ? CO = K 2 ? HR ? ( S - D ) ? ( PAT - PEP ) 2 where K1 and K2 are patient-specific calibration factors, PAT is the pulse arrival time, PEP is the pre-ejection period and PTT is the pulse transit time, the time taken for a pulse wave to travel between two points in the body of the patient.
    Type: Grant
    Filed: April 23, 2013
    Date of Patent: May 3, 2016
    Assignee: Koninklijke Philips N.V.
    Inventor: Jens Muhlsteff
  • Patent number: 9155482
    Abstract: An apparatus for indicating cardiac output comprises means for monitoring a patient's transthoracic impedance and generating a corresponding impedance signal, and signal processing means for (a) deriving a signal S1 which is a measure of the average amplitude of the impedance signal, (b) filtering the impedance signal at a plurality of different wavelengths within a predetermined frequency band, (c) for each filter deriving a signal S2 which is a measure of the average amplitude of the respective filter output, (d) calculating the ratio of the maximum one of the signals S2 derived from step (c) to the signal S1 derived from step (a), and (e) using the ratio from step (d) in a decision tree to provide a signal indicating cardiac output or not.
    Type: Grant
    Filed: March 4, 2009
    Date of Patent: October 13, 2015
    Assignee: Heartsine Technologies Limited
    Inventors: John McCune Anderson, Cesar Oswaldo Navarro-Paredes, Rebecca DiMaio
  • Patent number: 9084585
    Abstract: Methods, systems, and computer storage media are provided for determining whether a patient suffers from one or both of a recent deterioration in left ventricular function and a recent deterioration in mitral valve function. Transbrachial impedance velocimetry data and arterial pressure waveform data is received from a particular patient at a plurality of timepoints. An extent of deterioration is determined using a copula analysis of the patient data, and a statistical norm is determined for the patient's left ventricular function and mitral valve function. A current data value is received from the patient, including current transbrachial impedance velocimetry data and arterial pressure waveform data. The current data value is compared to the patient's statistical norm to determine whether the patient suffers from a recent deterioration in left ventricular function and/or mitral valve function.
    Type: Grant
    Filed: October 6, 2011
    Date of Patent: July 21, 2015
    Assignee: CERNER INNOVATION, INC.
    Inventor: Douglas S. McNair
  • Publication number: 20150148695
    Abstract: A method of assessing the likelihood that an infected subject develops sepsis, using an input radiofrequency signal received from the subject responsively to an output radiofrequency signal transmitted to the subject. The method comprises: processing the input signal to provide a processed signal, analyzing the processed signal to determine a characteristic pulse morphology of the processed signal, and using the characteristic pulse morphology for assessing the likelihood that the subject develops sepsis.
    Type: Application
    Filed: June 5, 2013
    Publication date: May 28, 2015
    Inventors: Yoav Avidor, Baruch Levy
  • Publication number: 20150141769
    Abstract: Novel tools and techniques for assessing, predicting and/or estimating effectiveness of fluid resuscitation of a patient and/or an amount of fluid needed for effective resuscitation of the patient, in some cases, noninvasively.
    Type: Application
    Filed: November 14, 2014
    Publication date: May 21, 2015
    Inventors: Isobel Jane Mulligan, Gregory Zlatko Grudic, Steven L. Moulton
  • Publication number: 20150133796
    Abstract: Systems and methods using a database of physiological information for the design, development, testing and use of therapeutics. In one aspect, the physiological information can include at least one of: hemodynamic monitoring information, pulmonary arterial pressure, cardiac output, heart rate, respiratory rate, peripheral vascular resistance, total peripheral resistance or dicrotic notch information. Optionally, the cardiovascular physiology information can include ambulatory physiological information.
    Type: Application
    Filed: November 6, 2014
    Publication date: May 14, 2015
    Inventor: Jay Yadav
  • Publication number: 20150126820
    Abstract: There is provided a method of determining a measure of the cardiac output, CO, of a patient, the method comprising obtaining measurements of one or more physiological characteristics of the patient, the physiological characteristics including at least the heart rate, HR, of the patient, the systolic blood pressure, S, of the patient and the diastolic blood pressure, D, of the patient; and processing the measurements to determine a measure of the cardiac output of the patient; wherein the measure of the cardiac output of the patient is derived using the relationship (I), CO=K2HR(S?D)(PTT)2, and/or CO=K2HR(?D)(PAT?PEP)2 where K1 and K2 are patient-specific calibration factors, PAT is the pulse arrival time, PEP is the pre-ejection period and PTT is the pulse transit time, the time taken for a pulse wave to travel between two points in the body of the patient.
    Type: Application
    Filed: April 23, 2013
    Publication date: May 7, 2015
    Inventor: Jens Muhlsteff
  • Publication number: 20150112219
    Abstract: Hardware and software methodology are described for non-invasively monitoring cardiac health. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic frequencies in two domains in two domains across the Dicrotic Notch. Together with associated notch timing, heart rate and blood pressure values left ventricle ejection fraction and/or stroke volume can be determination.
    Type: Application
    Filed: October 17, 2014
    Publication date: April 23, 2015
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Niema Pahlevan, Peyman Tavallali, Derek Rinderknecht, Morteza Gharib
  • Patent number: 9011346
    Abstract: In accordance with embodiments of the present disclosure, a ballistocardiogram (BCG) sensor is used to detect heart and vascular characteristics of a user, and provide a BCG output indicative of the detected cardiovascular characteristics. The BCG output can be used for various purposes, such as detecting arterial aging. Secondary sensors can be used in conjunction with the BCG and can be used to determine the central arterial blood pressure, when used in conjunction with a peripheral blood pressure measurement.
    Type: Grant
    Filed: January 26, 2012
    Date of Patent: April 21, 2015
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Richard M. Wiard, Laurent B. Giovangrandi, Gregory T. Kovacs
  • Patent number: 9008761
    Abstract: Sensing is carried out from locations considerably removed from the stomach. Cooperating sensor electronics are placed at each of two wrists of the patient. The potential discomfort and inconvenience of an abdominal patch are reduced or eliminated, and alternative power sources become available.
    Type: Grant
    Filed: November 6, 2012
    Date of Patent: April 14, 2015
    Assignee: Proteus Digital Health, Inc.
    Inventor: Mark Zdeblick
  • Publication number: 20150088018
    Abstract: The present disclosure introduces systems and methods to measure fluid in a body segment. In one embodiment, a computer system used to measure fluid in a body segment is described. A current generation module may be used to emit an electrical through at least one body segment. The electrical current may be used to measure fluid-volume content of the at least one body segment. An electrode module having a plurality of electrodes may be attached to the current generation module. A signal-processing module may be used to measure changes in the electrical current through at least one body segment. Further, an impedance module may be used to calculate fluid-volume change in at least one body segment and determine the flow of fluid through the at least one body segment. Other embodiments also are described.
    Type: Application
    Filed: May 27, 2014
    Publication date: March 26, 2015
    Inventor: Mamdouh Monif Monif
  • Patent number: 8965495
    Abstract: An implantable electronic therapy device, having a therapy unit, a heart rate capturing unit, a contractility determination unit, and an evaluation and control unit. The therapy unit delivers an antitachycardiac therapy. The heart rate capturing unit determines a ventricular heart rate from an input signal, and the contractility determination unit generates from an input signal, a contraction signal reflecting a contractility of a ventricle. The evaluation and control unit is connected to the therapy unit, the heart rate capturing unit, and the contractility determination unit actuates the therapy unit to administer an antitachycardiac therapy when the heart rate capturing unit detects an increase in the heart rate above a specified threshold value and the contractility determination unit supplies a contraction signal which is not physiologically adequate for the increase in the heart rate.
    Type: Grant
    Filed: August 1, 2011
    Date of Patent: February 24, 2015
    Assignee: Biotronik Se & Co. KG
    Inventor: Thomas Doerr
  • Publication number: 20150025328
    Abstract: A system for measuring of cardiac output and cardiac performance parameters based on a cardiac blood flow balance parameter between a right chamber of the heart and a left chamber of the heart, includes a sensor device for measuring one of blood pressure and blood flow rate and blood constituent concentration of a patient so as to generate an arterial pulse signal. A processing unit is responsive to the arterial pulse signal for generating a full arterial pulse signal, an arterio-venous pulse signal, and a balance parameter. A computational device is responsive to the balance parameter for further generating cardiac output and a set of cardiac performance parameters. A display station device is responsive to the set of physiological parameters from the computational device for displaying meaningful information.
    Type: Application
    Filed: July 19, 2013
    Publication date: January 22, 2015
    Inventor: Mohammad Khair
  • Publication number: 20150025335
    Abstract: The present disclosure provides a method and system for monitoring intensity of pain experienced by one or more users. The method includes measuring the intensity of pain experienced by the one or more users from a pre-determined set of one or more bio-markers using a pre-determined set of one or more bio-sensors, determining a correlation between the one or more bio-markers from the pre-determined set of one or more bio-markers and the intensity of pain experienced by the one or more users, refining the correlation between the one or more bio-markers from the pre-determined set of one or more bio-markers and the intensity of pain experienced by the one or more users by learning from responses of one or more similar users and generating a pain profile for each of the one or more users.
    Type: Application
    Filed: September 26, 2014
    Publication date: January 22, 2015
    Inventors: Lakshya JAIN, Priya BISARYA
  • Patent number: 8915860
    Abstract: Systems and methods are described herein to evaluate a candidate medication as it relates to a subject's cardiovascular health. A processing component is employed to measure a first value of one or more cardiovascular markers, via a computer, which are associated with a circulatory system of each subject that is to receive the candidate medication. The candidate medication is administered to each subject and a second value of one or more cardiovascular markers are measured subsequent to the administration as of the candidate medication. Continued testing of the candidate medication can be continued dependent upon the change in the one or more cardiovascular markers.
    Type: Grant
    Filed: November 4, 2010
    Date of Patent: December 23, 2014
    Inventor: Robert P. Blankfield
  • Patent number: 8911379
    Abstract: A method and system are presented for use in assessment of at least one cardiac parameter of an individual. An electrodes arrangement is applied to an individual's body, for applying an electrical field to the body and providing an electrical output indicative of a systolic impedance change and of a velocity of said change during a cardiac cycle. Also provided is additional data indicative of at least of the following conditions of the individual: a value of total peripheral resistance (TPR), a value of cardiac index (CI), and existence of the AHF condition.
    Type: Grant
    Filed: September 4, 2007
    Date of Patent: December 16, 2014
    Assignee: New N.I. Medical (2011) Ltd.
    Inventors: Daniel A. Goor, Efim Frinerman, Evgeny Granov, Igor Granov
  • Patent number: 8880352
    Abstract: A system and a method of analyzing an electrophysiological signal, wherein the system comprises an acquisition device for acquiring a test electrophysiological signal associated with an anatomical part of a patient and a processor configured to divide a cycle of the test electrophysiological signal into test time windows, compare a test signal value of each of the test time windows with a reference signal value of reference time windows of the reference segments of respective representations representing respective predetermined morphological classes to obtain a difference, define grid points associated with respective test time windows, respective reference time windows and respective differences, obtain a warping path using the grid points non-linearly in a predetermined order, sum differences along the grid points of each of the warping paths to obtain a cumulative distance for each of the warping paths, and classify the test electrophysiological signal into one of the respective predetermined morphologica
    Type: Grant
    Filed: November 29, 2010
    Date of Patent: November 4, 2014
    Assignee: Siemens Aktiengesellschaft
    Inventors: Amit Kale, Stefan Kimmer, Kaustubh Kulkarni
  • Patent number: 8870780
    Abstract: Characteristics of a user's heart are detected. In accordance with an example embodiment, a ballistocardiogram (BCG) sensor is used to detect heart characteristics of a user, and provide a BCG output indicative of the detected heart characteristics. The BCG output is further processed using data from one or more additional sensors, such as to reduce noise and/or otherwise process the BCG signal to characterize the user's heart function.
    Type: Grant
    Filed: October 14, 2009
    Date of Patent: October 28, 2014
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Omer T. Inan, Mozziyar Etemadi, Laurent B. Giovangrandi, Gregory T. Kovacs, Richard M. Wiard
  • Publication number: 20140316287
    Abstract: Embodiments provide systems and methods for displaying a fluid responsiveness predictor (FRP) based on an analysis a physiological signal detected by a physiological sensor applied to a patient. A method may include detecting the signal of the patient with the physiological sensor, determining an FRP with a FRP determination module, wherein the determining operation comprises analyzing at least one characteristic of the physiological signal over time to determine the FRP, receiving a report request to report the FRP at a requested time through a user interface, generating a reported FRP in relation to the requested time using the FRP determination module, and displaying the reported FRP on a display. The displaying operation may include displaying the FRP using at least one graphic representation.
    Type: Application
    Filed: April 17, 2014
    Publication date: October 23, 2014
    Applicants: COVIDIEN LP, COVIDIEN LP
    Inventors: James Nicholas Watson, Paul Stanley Addison
  • Patent number: 8868175
    Abstract: A method of estimating stroke volume of the heart is described. In this method, the volume of the heart is estimated from electrical impedance data of the chest, at two different phases of the cardiac cycle. The stroke volume is estimated from the difference between the volumes estimated at the two phases.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: October 21, 2014
    Assignee: Tel Aviv University Future Technology Development L.P.
    Inventor: Shimon Arad (Abboud)
  • Patent number: 8858449
    Abstract: Characteristics of a user's heart are detected. In accordance with an example embodiment, a ballistocardiogram (BCG) sensor is used to detect heart characteristics of a user, and provide a BCG output indicative of the detected heart characteristics. The BCG output is further processed using data from one or more additional sensors, such as to reduce noise and/or otherwise process the BCG signal to characterize the user's heart function.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: October 14, 2014
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Omer T. Inan, Mozziyar Etemadi, Laurent B. Giovangrandi, Gregory T. Kovacs, Richard M. Wiard
  • Publication number: 20140296727
    Abstract: Methods for detecting parameters in cardiac output related waveforms are described. The methods include methods for detecting individual heart beat cycles in a cardiac output related waveform, methods for detecting an error in an assigned starting point for an individual heart beat cycle in a cardiac output related waveform, methods for detecting a dichrotic notch for an individual heart beat cycle in a cardiac output related waveform, and methods for detecting an error in an assigned dichrotic notch for an individual heart beat cycle in a cardiac output related waveform. The identification of these parameters is important for a clinician as these parameters form the basis for the calculation of many other cardiac output related parameters.
    Type: Application
    Filed: June 11, 2014
    Publication date: October 2, 2014
    Applicant: Edwards Lifesciences Corporation
    Inventors: Feras Al Hatib, Luchy Roteliuk
  • Publication number: 20140276071
    Abstract: Apparatus and methods for calculating cardiac output (CO) of a living subject. In one embodiment, the apparatus and methods build a nonlinear mathematical model to correlate physiologic source data vectors to target CO values. The source data vectors include one or more measurable or derivable parameters such as: systolic and diastolic pressure, pulse pressure, beat-to-beat interval, mean arterial pressure, maximal slope of the pressure rise during systole, the area under systolic part of the pulse pressure wave, gender (male or female), age, height and weight. The target CO values are acquired using various methods, across a plurality of individuals. Multidimensional nonlinear optimization is then used to find a mathematical model which transforms the source data to the target CO data. The model is then applied to an individual by acquiring physiologic data for the individual and applying the model to the collected data.
    Type: Application
    Filed: March 14, 2013
    Publication date: September 18, 2014
    Inventors: Patrick Hunziker, Oleksii Morozov, Felix Friedrich
  • Publication number: 20140275976
    Abstract: A method for evaluating diastolic function of a heart includes measuring a volumetric flow of blood through the heart and determining volume change rates during a diastolic flow period. A diastolic index is formulated from a combination of volume change rates and features of the volumetric change and is weighted by the index for evaluating the weighted feature at a heightened sensitivity against a preselected value. The index weighting provides a measure of diastolic filling performance specific to the weighting parameter. As a result, guidance is provided in evaluating volume changes in heart failure patients, cardiac diastolic performance, medication/titration for diastolic performance, an athletic training program, and cardiac reserve. Guidance is also provided for improving exercise capacity in patients with diastolic dysfunction without requiring the patient to be evaluated during exertion.
    Type: Application
    Filed: December 17, 2013
    Publication date: September 18, 2014
    Applicant: ADVENTIST HEALTH SYSTEM/SUNBELT, INC.
    Inventor: Richard J. Moro
  • Publication number: 20140275937
    Abstract: Apparatus and methods for calculating cardiac output (CO) of a living subject using applanation tonometry measurements. In one embodiment, the apparatus and methods build a nonlinear mathematical model to correlate physiologic source data vectors to target CO values. The source data vectors include one or more measurable or derivable parameters such as: systolic and diastolic pressure, pulse pressure, beat-to-beat interval, mean arterial pressure, maximal slope of the pressure rise during systole, the area under systolic part of the pulse pressure wave, gender (male or female), age, height and weight. The target CO values are acquired using various methods, across a plurality of individuals. Multidimensional nonlinear optimization is then used to find a mathematical model which transforms the source data to the target CO data. The model is then applied to an individual by acquiring physiologic data for the individual and applying the model to the collected data.
    Type: Application
    Filed: March 14, 2013
    Publication date: September 18, 2014
    Inventors: Oliver Goedje, Matthias Bohn, Patrick Hunziker, Oleksii Morozov, Felix Friedrich
  • Patent number: 8827918
    Abstract: A ballistocardiogram-based personal authentication method includes detecting ballistocardiogram training signals of persons to be registered, extracting training features from the detected ballistocardiogram training signals, generating training data for personal authentication based on the extracted training features, detecting ballistocardiogram authentication signals of persons to be authenticated, and comparing the ballistocardiogram authentication signals and the training data to determine whether or not to perform the personal authentication of the persons to be authenticated. Thereby, the personal authentication method can perform personal authentication according to feature of a ballistocardiogram of each individual.
    Type: Grant
    Filed: May 6, 2013
    Date of Patent: September 9, 2014
    Assignee: Seoul National University R&DB Foundation
    Inventors: Heechan Kim, Seungwoo Noh, Chiyul Yoon
  • Publication number: 20140249441
    Abstract: The invention provides a system for measuring stroke volume (SV), cardiac output (CO), and cardiac power (CP) from a patient that features: 1) an impedance sensor connected to at least two body-worn electrodes and including an impedance circuit that processes analog signals from the electrodes to measure an impedance signal (e.g. a TBEV waveform); 2) an ECG sensor connected to at least two chest-worn electrodes and including an ECG circuit that processes analog signals from the electrodes to measure and ECG signal; 3) an optical sensor connected to a body-worn optical probe and including an optical circuit that processes signals from the probe to measure at least one optical signal (e.g. a PPG waveform) from the patient; 4) a processing system, typically worn on the patient's wrist and connected through a wired interface to the optical sensor, and through either a wired or wireless interface to the TBEV and ECG sensors.
    Type: Application
    Filed: December 28, 2011
    Publication date: September 4, 2014
    Inventors: Matt Banet, Isaac HENRY, Donald BERNSTEIN
  • Publication number: 20140249440
    Abstract: The invention provides a system for measuring stroke volume (SV), cardiac output (CO), and cardiac power (CP) from a patient that features: 1) impedance sensor connected to at least two body-worn electrodes and including an impedance circuit that processes analog signals from the electrodes to measure an impedance signal (e.g. a TBEV waveform); 2) an ECG sensor connected to at least two chest-worn electrodes and including an ECG circuit that processes analog signals from the electrodes to measure and ECG signal; 3) an optical sensor connected to a body-worn optical probe and including an optical circuit that processes signals from the probe to measure at least one optical signal (e.g. a PPG waveform) from the patient; 4) a processing system, typically worn on the patient's wrist and connected through a wired interface to the optical sensor, and through either a wired or wireless interface to the TBEV and ECG sensors.
    Type: Application
    Filed: December 27, 2011
    Publication date: September 4, 2014
    Inventors: Matt BANET, Isaac HENRY, Donald BERNSTEIN
  • Publication number: 20140249442
    Abstract: The invention provides a system for measuring stroke volume (SV), cardiac output (CO), and cardiac power (CP) from a patient that features: 1) an impedance sensor connected to at least two body-worn electrodes and including an impedance circuit that processes analog signals from the electrodes to measure an impedance signal (e.g. a TBEV waveform); 2) an ECG sensor connected to at least two chest-worn electrodes and including an ECG circuit that processes analog signals from the electrodes to measure and ECG signal; 3) an optical sensor connected to a body-worn optical probe and including an optical circuit that processes signals from the probe to measure at least one optical signal (e.g. a PPG waveform) from the patient; 4) a processing system, typically worn on the patient's wrist and connected through a wired interface to the optical sensor, and through either a wired or wireless interface to the TBEV and ECG sensors.
    Type: Application
    Filed: December 28, 2011
    Publication date: September 4, 2014
    Inventors: Matt BANET, Isaac HENRY, Donald BERNSTEIN
  • Publication number: 20140249443
    Abstract: The invention provides a system for measuring stroke volume (SV), cardiac output (CO), and cardiac power (CP) from a patient that features: 1) an impedance sensor connected to at least two body-worn electrodes and including an impedance circuit that processes analog signals from the electrodes to measure an impedance signal (e.g. a TBEV waveform); 2) an ECG sensor connected to at least two chest-worn electrodes and including an ECG circuit that processes analog signals from the electrodes to measure and ECG signal; 3) an optical sensor connected to a body-worn optical probe and including an optical circuit that processes signals from the probe to measure at least one optical signal (e.g. a PPG waveform) from the patient; 4) a processing system, typically worn on the patient's wrist and connected through a wired interface to the optical sensor, and through either a wired or wireless interface to the TBEV and ECG sensors.
    Type: Application
    Filed: December 28, 2011
    Publication date: September 4, 2014
    Inventors: Matt BANET, Isaac HENRY, Donald BERNSTEIN
  • Patent number: 8821406
    Abstract: An introducer sheath/temperature probe assembly that is insertable into a blood vessel of a human or veterinary patent to measure the temperature of blood flowing through that blood vessel. The introducer sheath/temperature probe assembly may be used in conjunction with an indwelling heat exchange catheter system to warm or cool all or a portion of the patient's body to a desired target temperature and to maintain such target temperature for a desired period of time.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: September 2, 2014
    Assignee: ZOLL Circulation, Inc.
    Inventors: Jeffrey P. Callister, Michael W. Dae, Amy L. Hammack
  • Publication number: 20140243696
    Abstract: A computerized method for monitoring cardiac output of a subject by a processor executing the method, the method comprising the steps of: determining first values of cardiac output of the subject for a first period of time using respective different cardiac output measurement methods having respective first measurement errors; and combining the determined first values of cardiac output to determine a second value of cardiac output of the subject for the first period of time, such that the second value of cardiac output has a second measurement error that is less than any of the first measurement errors; and at least one of storing, outputting, and displaying data representing the determined second value of cardiac output of the subject.
    Type: Application
    Filed: January 30, 2014
    Publication date: August 28, 2014
    Applicant: Austin Health
    Inventor: Philip John Peyton
  • Patent number: 8808191
    Abstract: A method of and a device for non-invasively measuring the hemodynamic state of a subject or a human patient involve steps and units of non-invasively measuring cardiac cycle period, electrical-mechanical interval, mean arterial pressure, and ejection interval and converting the measured electrical-mechanical interval, mean arterial pressure and ejection interval into the cardiac parameters such as Preload, Afterload and Contractility, which are the common cardiac parameters used by an anesthesiologist. The converted hemodynamic state of a patient is displayed on a screen as a three-dimensional vector with each of its three coordinates respectively representing Preload, Afterload and Contractility. Therefore, a medical practitioner looks at the screen and quickly obtains the important and necessary information.
    Type: Grant
    Filed: July 27, 2009
    Date of Patent: August 19, 2014
    Inventor: Robert Hirsh
  • Patent number: 8771197
    Abstract: Methods for detecting parameters in cardiac output related waveforms are described. The methods include methods for detecting individual heart beat cycles in a cardiac output related waveform, methods for detecting an error in an assigned starting point for an individual heart beat cycle in a cardiac output related waveform, methods for detecting a dichrotic notch for an individual heart beat cycle in a cardiac output related waveform, and methods for detecting an error in an assigned dichrotic notch for an individual heart beat cycle in a cardiac output related waveform. The identification of these parameters is important for a clinician as these parameters form the basis for the calculation of many other cardiac output related parameters.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: July 8, 2014
    Assignee: Edwards Lifesciences Corporation
    Inventors: Feras Hatib, Luchy Roteliuk
  • Publication number: 20140187971
    Abstract: Methods and apparatuses are described to obtain cardiac data, which includes acquiring vibrational field cardiac data from a transducer wherein the transducer measures vibration over a surface of a human's body. An unwanted coronary event is separated from vibrational cardiac data. A transient event is extracted from the vibrational cardiac heart cycle data. The transient event occurs during a diastolic interval within a heart cycle. The transient event is evaluated for a condition of coronary artery blood flow turbulence and a condition of health of a coronary artery is assessed from a feature in the vibrational frequency power spectrum estimate.
    Type: Application
    Filed: March 18, 2013
    Publication date: July 3, 2014
    Applicant: PHONOFLOW MEDICAL, LLC
    Inventors: Norman Lee Owsley, Roger Paul Norris, Ralph Walter Zaorski
  • Publication number: 20140187992
    Abstract: A system for non-invasively determining cardiac output of a patient may include a physiological signal detection unit and a cardiac output determination module. The physiological signal detection unit may be configured to detect first and second physiological signals with respect to first and second locations of vasculature of the patient. The cardiac output determination module may be configured to receive the first and second physiological signals and calculate the cardiac output of the patient based, at least in part, on a phase difference between the first and second physiological signals.
    Type: Application
    Filed: January 3, 2013
    Publication date: July 3, 2014
    Applicant: Covidien LP
    Inventor: Tom Wilmering