Abstract: An audio/video recording method and device for recording a main audio/video file and at least one index audio/video file corresponding to the main audio/video file. A section of the index audio/video files can be transformed into text data serving as a portion of file names of the main audio/video file. When a user collates or uses the main audio/video file, the index audio/video file is used to accelerate distinguishing what the main audio/video files are, thereby facilitating searching, classification and management of the main audio/video file effectively.

Abstract: The disclosure relates to IL-13 antagonists, in particular anti-human-IL-13 antibodies and human-IL-13-binding fragments thereof, and their use for improvement, maintenance or reduction in the rate of decline of pulmonary function in a subject with impaired pulmonary function, which may be associated with uncontrolled moderate-to-asthma, COPD or IPF.

Abstract: A nebulizer includes a main body that has a nebulizer outlet and an air channel in communication with the nebulizer outlet. The main body supports a medicine reservoir and a mesh that engages the medicine reservoir and air channel and vibrates to atomize medicine from the medicine reservoir into the air channel for discharge through the nebulizer outlet. The nebulizer outlet and mesh are configured to be received within the oral cavity of the patient when the nebulizer is in use.

Abstract: A monitoring system is used to measure various parameters of the sleep, respiration, and/or other bodily functions of a subject. One or more metrics are calculated that quantify deviation from the mean, trends, changes over time, and/or other changes in the parameters. The metrics are used to generate notifications of these changes that can be conveyed to caregivers and/or other users.

Abstract: Embodiments described herein may include systems and methods for detecting events that may be associated with sleep apnea. Some embodiments are directed to a system and/or method for automated detection of reduction in airflow events using polysomnograph signals, wherein the reduction in airflow events may relate to sleep apnea. The PSG signals may be limited to four signals, including data from an airflow channel, a blood oxygen saturation channel, a chest movement channel, and an abdomen movement channel. Using information from these channels, some embodiments may automatically identify reduction in airflow events.

Abstract: The present invention relates to an integrated sleep diagnosis and treatment device, and more particularly to an integrated apnea diagnosis and treatment device. The present invention additionally relates to methods of sleep diagnosis and treatment. The sleep disorder treatment system of the present invention can use a diagnosis device to perform various forms of analysis to determine or diagnose a subject's sleeping disorder or symptoms of a subject's sleep disorder, and using this analysis or diagnosis can with or in some embodiments without human intervention treat the subject either physically or chemically to improve the sleeping disorder or the symptoms of the sleeping disorder. The diagnostic part of the system can use many different types of sensors and methods for diagnosing the severity of the symptoms of or the sleep disorder itself. The treatment part of the system can use a device to physically or chemically treat the subject's symptoms or sleep disorder itself.

Abstract: The present invention describes a method and apparatus for detecting and quantifying intrinsic positive end-expiratory pressure (PEEPi) of a respiratory patient breathing with the assistance of a ventilator. A processing device receives respiratory airway data from one or more sensors adapted to non-invasively monitor a respiratory patient, calculates from the respiratory airway data two or more parameters that are indicative of or quantify intrinsic positive end-expiratory pressure of the patient, and generates a predicted quantitative value for intrinsic positive end-expiratory pressure based on the two or more parameters. The respiratory airway data is transformed into a predicted quantitative value for intrinsic positive end-expiratory pressure (PEEPi).

Abstract: Minimally invasive methods, systems and devices are provided for assessing collateral ventilation in the lungs. In particular, collateral ventilation of a target compartment within a lung of a patient is assessed by advancement of a catheter through the tracheobronchial tree to a feeding airway of the target compartment. The feeding airway is occluded by the catheter and the opening and closing of a one-way valve coupled with the catheter is observed. If the valve ceases opening and closing over time, this may indicate that significant collateral ventilation into the target compartment is absent. If the valve continues to open and close over time, significant collateral ventilation into the compartment may be present. Based on the collateral ventilation assessment, a treatment plan may be generated.

Abstract: The invention comprises a measurement device for lung function measurement comprising a flow tube forming an air-flow path, an actuator for closing and opening the flow tube and at least one sensor for measuring at least one lung function variable, wherein the actuator is arranged to force the flow tube to close the air-flow path by pressing the tube against a wall of the flow tube.

Abstract: A method and a microprocessor controlled device for use in medical evaluation of the pulmonary system. The method and device incorporate two different non invasive evaluative techniques. Passive auscultation provides indicators of lung condition. Active auscultation, a different evaluative technique, provides information or indications generally not available or provided from passive auscultation. Combining the information from both techniques greatly improves the ability to provide effective medical treatment.

Abstract: There is provided a method of evaluating a liver condition of a subject, the method includes computing a fluctuation parameter from a liver breath test based on at least one of a percentage dose recovery (PDR) curve and a delta over baseline (DOB) curve of an isotope labeled methacetin, or a salt or a derivative thereof, and evaluating at least one liver condition of the subject, based at least on the fluctuation parameter. There is provided herein a method of evaluating a liver condition of a subject, the method includes computing a hepatic impairment score based at least on a breath test related parameter and on a demographic parameter.

Abstract: A novel augmented incentive spirometer that will deliver pressurized oxygen, or air when the patient inhales, therefore increasing the inspired volume over the amount of volume generated only by the patient's effort.

Abstract: A system for measuring spirometric flow rate using a microphone and a mobile computer device connected to or integrated with the microphone. The mobile computer device may include a processor and storage. The storage may be operatively connectible, e.g over a network, to a computer system used by a practitioner. The system has a transducer adapted for converting spirometric flow rate into an audible signal with an audio frequency characteristic of the spirometric flow rate. The microphone is external to the transducer and may be adapted to detect the audible signal having an audio frequency and to convert the audible signal to a corresponding electrical signal having the audio frequency. The audio frequency may be characteristic of a peak expiratory flow rate and the output result is characteristic of the peak expiratory flow rate.

Abstract: An apparatus includes a mouthpiece to communicate an airflow between a user and an airflow chamber in fluid communication with the mouthpiece; an interrupter in fluid communication with the airflow chamber and adapted to initiate an occlusion event by adjusting between an open state and a closed state, such that fluid communication is at least partially prevented between the airflow chamber and ambient air during the occlusion event initiated by the interrupter; a container in fluid communication with the airflow chamber; a flow rate sensor in fluid communication with the airflow chamber and adapted to measure an airflow exchange between the airflow chamber and the container during the occlusion event; and a controller adapted to determine an instantaneous lung volume based on the measured airflow exchange between the airflow chamber and the container.

Abstract: There is provided an apparatus for use in diagnosing the presence of obstructive sleep apnea in a patient, the apparatus comprising a processor configured to receive signals representing measurements of a patient's breathing obtained during a plurality o breathing cycles by the patient while the patient is awake, convert the signals into the frequency domain and to determine a value for at least one parameter based on an analysis of the frequency-domain converted signals in one or more frequency bands covering frequencies below 100 Hz.

Abstract: A system, medium, and method conducing a user's breathing, in which a sound generated during a user's exhale and/or an ambient temperature change occurring during the exhale is sensed to measure a respiratory waveform of the user. Respiratory information of the user may then be produced from the respiratory waveform, and when the respiratory information of the user is different from normal respiratory information of the user, breathing information according to the normal respiratory information may be provided to the user so the user can use the same to modify their breathing.

Abstract: Disclosed is a mask for use in respiratory monitoring and/or diagnostics. The mask comprises at least one transducer responsive to sound and/or airflow for generating a signal, and a support structure to rest on the subject's face. In one embodiment, the support structure comprises two or more limbs that provide a transducer support for supporting the transducer at a distance from a nose and mouth area, allowing monitoring via the transducer of sound and/or airflow produced by the subject. Also described is a mask comprising a transducer responsive to airflow for generating a signal and a support structure to rest on the subject's face and extend outwardly over a nose and mouth area to provide a transducer support supporting the transducer at a distance from a nose and mouth area of the subject's face and at a preset orientation, for monitoring via the transducer of airflow produced by the subject.

Abstract: A compound membrane breathing tube for use in spirometric applications is provided. The compound membrane comprises a first sheet and a second sheet of flexible sheeting connected together along the periphery thereof, and each of the sheets has an opening cut therethrough to create a flap. The flap of the first sheet overlaps the flap of the second sheet so as to present a higher relative resistance to airflow through the breathing tube at lower airflows.

Abstract: A pneumostoma assessment and treatment system includes methods and devices for aftercare of a pneumostoma. In particular, methods and devices are provided for standardized monitoring and assessment of pneumostoma patency thereby facilitating the establishment of standards-based protocols for pneumostoma management. Methods of standardized pneumostoma patency assessment includes the use of devices for raising alveolar pressure to a controlled repeatable pressure above ambient while analyzing gas flow through the pneumostoma. In response to an assessment the functionality of the pneumostoma, the tissues of the pneumostoma may be treated with a treatment device utilizing one or more different modalities to preserve or enhance the health and function of the pneumostoma.

Abstract: The present invention relates generally to diagnosing chronic obstructive pulmonary disease (COPD) and estimating of the severity thereof, in particularly the occurrence of emphysema. More particularly the present invention relates to a system and method for computerized quantification of airway collapse during forced expiration or total exhalation. Such airway collapse is correlated with the presence of emphysema that has been verified on computer tomography (CT) scan and that is due to the loss of alveolar attachments in emphysema. Moreover the present invention provides a computerized apparatus for detection of emphysema, a computerized system for detection of emphysema or a method of computer-aided detection of emphysema.

Abstract: This disclosure describes systems and methods for conducting and terminating spontaneous breathing trials on patients receiving mechanical ventilation. The disclosure describes a novel spontaneous breathing trial manager for a medical ventilator with rapid initiation and continuous monitoring of a patient's tolerance of the spontaneous breathing trial and displaying of that tolerance as a function of time, which provides for bedside adjustment of the spontaneous breathing trial parameters and automatic termination of a spontaneous breathing trial based on a time interval expiration or poor patient tolerance of the SBT.

Abstract: An apparatus to measure cardiac output (Q) and other parameters such as alveolar ventilation (VA), minute CO2 elimination from the lung (VCO2), minute oxygen consumption (VO2), oxygenated mixed venous partial pressure of CO2, (PvCO2-oxy), true mixed venous partial pressure of CO2(PvCO2), PaCO2, mixed venous oxygen saturation (SvO2), pulmonary shunt, and anatomical dead space, consisting of: a) a breathing circuit with characteristics that: i. on exhalation, exhaled gas is kept substantially separate from inhaled gas; ii.

Abstract: A gas flow diverter for increasing the turbulence of an incoming respiratory gas flow through a respiratory gas sensor is provided. The diverter is positioned at a patient or inlet end of a tube section of the sensor in order to divert the respiratory gas flow from the patient generally equally across the cross-sectional area of the tube section. The diverter can be formed integrally as a part of the sensor, or can be releasably attached to the sensor or to an adapter that is releasably connected to the inlet end of the sensor for use in situations in which the volume of the incoming respiratory gas flow from the patient is greatly reduced due to the size of the patient, i.e., when the patient is an infant.

Abstract: A method of determining the respiratory function of a subject is disclosed, the method comprising measuring the concentration of water vapor in the gas stream exhaled by the subject, and from the measured water vapor concentration determining the respiratory function of the subject. Mathematical techniques for analyzing the data obtained from the measurement of concentrations of gaseous components in an exhaled gas stream are also disclosed and their use in determining the lung function of a subject.

Abstract: A self-actuated cylinder comprising a cylinder housing comprising electro-magnetic force generating means to generate electro-magnetic forces, and a piston within the cylinder housing, wherein the electro-magnetic forces act directly on the piston to displace the piston within the cylinder housing. The self-actuated cylinder can be used as an oscillation spirometer to determine air flow, an input impedance or Forced Oscillation pulmonary mechanics.

Abstract: According to embodiments, a respiration signal may be processed to normalize respiratory feature values in order to improve and/or simplify the interpretation and subsequent analysis of the signal. Data indicative of a signal may be received at a sensor and may be used to generate a respiration signal. Signal peaks in the respiration signal may be identified and signal peak thresholds may be determined. The identified signal peaks may be adjusted based on the signal peak threshold values to normalize the respiration signal.

Abstract: Herein disclosed is a peak expiratory flow rate measuring apparatus (PFM) having at least one measurement channel and at least one bypass flow channel comprising at least one entrance, at least one exit, at least an inner wall and an outer wall, and wherein at least a portion of said at least one bypass flow channel has a variable cross-sectional area. Further disclosed is a PFM having at least one measurement channel comprising at least one first flow entrance, at least one bypass flow channel comprising at least one second flow entrance, and at least one guide wall, having an axially forward portion adjacent to said second flow entrance and an axially aft portion adjacent to said first flow entrance.

Abstract: The present invention provides for a data acquisition system for EEG and other physiological conditions, preferably wireless, and method of using such system. The wireless EEG system can be used in a number of applications including both studies and clinical work. These include both clinical and research sleep studies, alertness studies, emergency brain monitoring, and any other tests or studies where a subject's or patient's EEG reading is required or helpful. This system includes a number of features, which enhance this system over other systems presently in the marketplace. These features include but are not limited to the having multiple channels for looking at a number of physiological features of the subject or patient, a built in accelerometer for looking at a subject's or patient's body motion, a removable memory for data buffering and storage, capability of operating below 2.

Abstract: Systems and methods are disclosed determining a pulmonary function by mounting one or more sensors intra-orally; capturing intra-oral data; and determining the pulmonary function based on an analysis of the intra-oral data.

Abstract: The present invention provides a method for measuring FeNO in a subject, wherein the FeNO data derived from a subject patient is normalized to compensate for variations of FeNO with flow rate.

Abstract: A method of intubating a subject is disclosed. The method comprises inserting an endotracheal tube into the tracheal airway of the subject; inflating a cuff associated with the endotracheal tube within the airway below the vocal cords; measuring a level of at least one measure being indicative of leakage of secretion past the cuff to the lungs; comparing the level of the measure with an optimal level of the measure; and adjusting inflation of the cuff based on the comparison so as to generally minimize leakage of secretion from above the cuff to the lungs, while minimizing pressure associated damages to the airway. The measure(s) can be carbon dioxide concentration, a proxy measure from which such concentration can be inferred, or the level of one or more additives delivered to a subject during intubation.

Abstract: This method for analyzing the respiratory activity of a patient comprises the steps (20) for acquiring at least one respiratory activity signal comprising at least one elementary signal corresponding to a respiratory cycle, the general form of which may be expressed by x(t)=x0+x1 cos (?(t)), wherein ?(t) is the phase of said elementary signal, and for analyzing (24, 26, 28) said respiratory activity signal.

Abstract: Methods for estimating the volume of the carbon dioxide stores of an individual's respiratory tract include determining a carbon dioxide store volume at which a correlation between corresponding signals of carbon dioxide elimination and an indicator of the content of carbon dioxide in blood of the individual is optimized. The estimate of the volume of carbon dioxide stores, which comprises a model of the respiratory tract, or lungs, of the individual, may be used as a transformation to improve the accuracy of one or both of the carbon dioxide elimination and carbon dioxide content signals. Transformation, or filtering, algorithms are also disclosed, as are systems in which the methods and algorithms may be used. The methods, algorithms, and systems may be used to accurately and noninvasively determine one or both of the pulmonary capillary blood flow and cardiac output of the individual.

Abstract: A method is disclosed for motivating a user of a spirometry system having a display screen, an air-tube, a flow measurement sensor operatively associated with the air-tube, a display screen, and an associated processor. A motivational animation is displayed on the display screen having a first aspect that reflects a relative evaluation of a determined peak flow rate to a goal value therefor and having a second aspect that reflects a relative evaluation of a determined total flow volume to a goal value therefor. The processor repeatedly updates the motivational animation during the period of use of the spirometer to reflect the degree of achievement of both of the goal values by the user.

Abstract: Systems and methods for monitoring incentive spirometry are disclosed. A patient measuring unit measures inhalation and/or exhalation flow and/or volume. The patient is instructed to follow a prescribed program of repeated inhalations and/or exhalations using the patient measuring unit. Feedback is provided to the patient to facilitate compliance with the prescribed program. All usage of the patient measuring unit is recorded and displays are provided for both the patient and an attending clinician. Prescribed performance targets are programmed, and alarms are set to indicate when prescribed targets are not met. Alarms can be set for minimum and maximum flow rates, minimum inhalation volume, minimum repeat count per set, maximum interval between sets, and maximum performance degradation compared to a recent average.

Abstract: A wake-to-sleep transition for a subject is detected based on responsiveness to breathing cues provided to the subject. A pressurized flow of breathable gas to the airway of subject having one or more gas parameters that are adjusted to provide breathing cues to the subject. Based on a detected conformance of the respiration of the subject to the breathing cues, a determination is made as to whether the subject is awake or asleep.

Abstract: A monitoring device to be used in conjunction with a patient's airway. Some embodiments of the monitoring device include at least one sensor assembly configured to detect inhaled and exhaled airflow and an optional communications subassembly configured to transmit measurements to at least one external computing device. Other embodiments include at least one sensor assembly configured to detect a measurement indicating airflow from the patient's lungs and at least one processor configured to detect whether the airflow is associated with medication administration or measurement of breathing characteristics. Some embodiments include a circuit that allows patient information to be analyzed by an external computing device and/or the monitoring device to determine whether the patient's breathing has declined indicating a medical problem.

Abstract: A training device for diaphragmal breathing exercises, the device including (a) a beaker having a substantially cylindrical shape, with a bottom on one end and an opening on the other end; (b) an inner chamber within the beaker, the inner chamber having a bottom end and an open end on the same side as the open end of the beaker; (c) a lid having inner and outer circumferential ridges, wherein the lid fittingly mounts over the open end of beaker using an outer ridge and fittingly mounts over the inner chamber using the inner ridge; and (d) the lid further having a tubular coupling portion. A breathing tube is fittingly coupled to the tubular coupling portion on one end. A mouthpiece mounted on the other end of the breathing tube. The bottom end of the inner chamber has a stepped shape with a plurality of openings on each step. The lid has a plurality of openings.

Abstract: A method is provided for predicting an onset of a clinical episode, the method including sensing breathing of a subject, determining at least one breathing pattern of the subject responsively to the sensed breathing, comparing the breathing pattern with a baseline breathing pattern, and predicting the onset of the episode at least in part responsively to the comparison. Other embodiments are also described.

Abstract: In a method, ventilator and ventilator control unit for determining an end-expertorial lung volume (EELV) for a mechanically ventilated patient, a breathing gas is provided to the patient that has a first fixed N2/O2 gas composition, at least until the N2/O2 gas composition in air expired from the patient is constant. At least once, at a first predetermined point in time, the N2/O2 gas composition in the breathing gas is changed to a second fixed composition. The change in the N2/O2 gas composition exhaled by the patient for each breath is measured until a second point in time at which the level of expired O2 in at least two subsequent breadths is substantially stable. The measurement is made downstream of the expiratory tube of the ventilator. The total gas volume is determined for each breath, and the EELV of the patient's lungs is determined based on the change in O2 level between the first and second points in time.

Abstract: Systems and methods provide for assessing the heart failure status of a patient and, more particularly, to generating a trend parameter based on a distribution of the patient's respiration rate. Systems and methods provide for detecting, using an implantable device or a patient-external device, patient respiration and computing a respiration rate based on the detected patient respiration. A distribution of the respiration rate is calculated, and a trend parameter based on the respiration rate distribution is generated. The trend parameter is indicative of a patient's heart failure status. An output signal indicative of the patient's heart failure status may be generated based on the trend parameter.

Abstract: A method for determining the respiratory flow of a patient receiving bi-level respiratory therapy is provided. The method may include measuring the total air flow through a breathing area at a time approximately when the patient has completed exhalation, measuring the pressure in the breathing area, determining a constant representing a corrective flow factor by dividing the measured total air flow by the square root of the measured pressure, and determining the patient's respiratory flow by subtracting from a subsequent total air flow the product of constant and the square root of a subsequent pressure.

Abstract: Embodiments of the present invention provide methods of extracting optimal information from a flow/volume loop concerning the patient's respiratory condition by examining the overall shape of the space under the flow/volume loop's expiration portion. In some embodiments, this is done with reference to the center of mass of that space. In some embodiments, this is done with reference to the area of that space. Some embodiments are significantly less affected by random/statistical variations and/or noise within the measurement system than existing methods.

Abstract: A method for analyzing lunch function includes receiving, at a signal generating device, an output of a respiratory maneuver, where the output of the respiratory maneuver includes one or more respiratory parameters. The method also includes producing, at the signal generating device, a signal corresponding to the output of the respiratory maneuver based on the one or more respiratory parameters, wherein the signal describes one or more characteristics of the respiratory maneuver. The method further comprises transmitting the signal from the signal generating device to a signal receiving device at a remote location over a network.

Abstract: An electronic catheter stethoscope measures and analyzes acoustic fields and dynamic pressure variations in the gaseous or liquid fluid inside a conventional medical catheter that is positioned in a patient's urologic, digestive, reproductive, cardiovascular, neurological or pulmonary system. Measurement transducers are installed in a housing connectable to multiple preselected medical catheters. The transducers detect bodily functions that are transmitted to the preselected catheter from within the body. The transducers, housing, electrical interface and signal processing electronics are positioned outside the body.

Abstract: An apparatus for measuring lung ventilation, comprising: a pressure device to measure volume of air flow; an aerosol-generating device that provides aerosol particles to be released at a determined point in a breathing cycle; a mouthpiece with a detector that measures the concentration of aerosol particles for a given volume during the breathing cycle; and a computing device configured to provide lung ventilation data as a function of time constants.

Abstract: Systems and methods for assessment of sleep quality in adults and children are provided. These techniques include an apparatus worn above the forehead containing the circuitry for collecting and storing physiological signals. The apparatus integrates with a sensor strip and a nasal mask to obtain the physiological signals for the user. The form factor of this apparatus is comfortable, easy to self-apply, and results in less data artifacts than conventional techniques for capturing physiological data for analyzing sleep quality. Neuro-respiratory signals are analyzed using means to extract more accurate definitions of the frequency and severity of sleep discontinuity, sleep disordered breathing and patterns of sleep architecture. Biological biomarkers and questionnaire responses can also be compared to a database of healthy and chronically diseased patients to provide a more accurate differential diagnosis and to help determine the appropriate disease management recommendations.

Abstract: Determining nasal resistance. At least some of the illustrative embodiments are methods including: applying negative pressure to a patient's mouth and thereby creating airflow that flows in a first nare and out the patient's mouth; measuring at least one property of the airflow during the causing; and determining an indicia of nasal resistance of the patient, the determining based on the at least one property.

Abstract: An implantable medical system for detecting incipient edema has an implantable medical lead including an optical sensor having a light source and a light detector. The medical system further has an edema detection circuit that activates the light source to emit light, the light being directed into lung tissue of a patient and that obtains a light intensity value corresponding to an intensity of light received by the light detector, and that evaluates the light intensity value to detect a consistency with incipient edema.

Abstract: A face mask (10) for a patient undergoing a sedated endoscopic procedure. The face mask (10) includes means (16, 17) to provide positive airway pressure to the nose, a bite block (18) with an opening therein (20) and a one-way valve (22). The one-way valve (22) has an open position, adapted to allow passage of an endoscopic device therethrough and into the opening (20), and a closed position substantially sealing the opening (20).