Abstract: A tympanostomy tube delivery device comprises a drive assembly and a force limiting shaft assembly. The shaft assembly comprises a cannula and a piercer operable to translate relative to the cannula so as to pierce the tympanic membrane of a patient. The piercer is mechanically coupled with the drive assembly such that actuation of the drive assembly causes translation of the piercer relative to the cannula. The piercer is mechanically coupled with the drive assembly by a clutch. The clutch is resiliently biased to couple the piercer with the drive assembly. The clutch is configured to uncouple the piercer from the drive assembly in response to a threshold force being imposed upon the piercer so as to inhibit translation of piercer relative to the cannula.

Abstract: A dilation catheter system includes a body and a shaft assembly. The shaft assembly extends passed a distal end of the body. The shaft assembly includes a fixed guide member, a catheter shaft, a dilator, a removable guide member, and a guidewire. The fixed guide member is fixed relative to the body. The dilator is fixed to the catheter shaft. The catheter shaft is operable to expand the dilator. The removable guide member is operable to selectively attach to the body. The catheter shaft is slidably disposed along the removable guide member such that the catheter shaft is configured to translate along the removable guide member. The guidewire is slidably disposed within the removable guide member.

Abstract: A device for tissue sampling that comprises a needle, a stylet and a sealing member. The needle comprises a distal tip, a proximal end, and one or more interior portions. The needle extends along a longitudinal axis extending between the distal tip and the proximal end. The stylet is moveably supported within the one or more interior portions of the needle. The sealing member Is moveably supported within the one or more interior portions of the needle and substantially conforms to the one or more interior portions, The distal tip is configured to obtain a tissue sample. The stylet and the sealing member are movable, along the longitudinal axis away from the distal tip so that a local vacuum is created at the distal tip so that obtained tissue samples can be aspirated into the needle.

Abstract: A bone marrow access device includes a cannula and a sharp stylet removably positioned in the cannula. The cannula defines a distal opening at a distal tip and a side aperture in a side of the cannula, proximally from the distal opening. The stylet has a sharp distal tip and extends beyond the distal opening. A plug is receivable in the cannula distal to the side aperture to seal the distal opening when the stylet is removed. A method of accessing bone includes inserting the cannula and sharp stylet positioned in the cannula into bone; removing the sharp stylet from the cannula; pushing a plug through the cannula and distal to the side aperture to seal the distal opening of the cannula; and accessing the bone through the side aperture. Accessing the bone can include aspirating bone marrow, injecting a substance, or inserting an instrument into the bone.

Abstract: Systems, apparatuses, and methods of and for an ophthalmic surgical system are disclosed. An ophthalmic surgical system may include a vitrectomy probe having a housing sized and shaped for grasping by a user. The vitrectomy probe may also include a cutter extending from the housing and being sized to penetrate and treat a patient eye. The cutter may include an outer cutting tube coupled to the housing. The outer cutting tube may have an outer port formed therein that is sized and shaped to receive tissue. The cutter may include a rotatable inner cutting member disposed within the outer cutting tube. The inner cutting member may include a first cutting surface that rotates across the outer port to cut the tissue when the inner cutting member is rotated. The vitrectomy probe may include a pneumatic vane actuator positioned within the housing and configured to rotate the inner cutting member.

Abstract: A surgical end effector includes a clevis and two jaws rotatably coupled to the clevis. Each jaw includes a face that is perpendicular to the axis of rotation of the jaw. A rocking pin is pivotally supported by the clevis. The opposite ends of the rocking pin engage the faces of the jaws to constrain the jaws to have opposite motions around the axes of rotation of the jaws. The clevis may be coupled to an elongate shaft with wires extending through the shaft to provide an endoscopic instrument. The jaws may be opened and closed by pushing and pulling on the wires. A wire guide may support the wires in the shaft such that they are able to transmit a compressive force without buckling. The wires may carry electricity to the jaws for electrocautery.

Abstract: A penetrator assembly for penetrating a bone and associated bone marrow is provided. The penetrator assembly may include a first connector having a first end and a second end; an outer penetrator extending from the second end of the first connector; the outer penetrator comprising a longitudinal passageway and a first tip; a second connector having a first end and a second end; and an inner penetrator extending from the second end of the second connector, the inner penetrator comprising a second tip. The first connector may be configured to engage the second connector, and the inner penetrator may be disposed in the longitudinal passageway of the outer penetrator when the first connector is engaged with the second connector.

Abstract: A biopsy device includes a housing body, and a cannula assembly having a first elongate cannula and a second elongate cannula coaxial with the first elongate cannula. The second elongate cannula has a side wall and a lumen. The side wall has a vacuum side port in fluid communication with the lumen. A vacuum source is positioned in the housing body. The vacuum source has a chamber side wall, which may define a U-shaped volume, and has a chamber vacuum port. A seal is interposed in sealing engagement between the chamber vacuum port and the second elongate cannula. A trigger slide assembly is configured to move the second elongate cannula to align the vacuum side port of the second elongate cannula with the chamber vacuum port of the vacuum source to supply vacuum from the vacuum source to the lumen of the second elongate cannula.

Abstract: A fluid injection needle has a relatively precision fluid flow path. The needle comprises a needle shaft and a sizing shaft axially extending within the needle shaft lumen a selected distance distal of a fluid entry port into the lumen. The sizing shaft has a cross-sectional size smaller than the lumen to define a fluid flow path between the sizing shaft and the needle shaft. An injection device employing such an injection needle and a method of making such a needle are also disclosed.

Abstract: Methods and devices are illustrated for improving a partial-core biopsy device whereby inner mandrel deflection and flexibility is reduced, the volume of space available for tissue collection is increased, and tissue migration is reduced.

Abstract: A minimally invasive tissue incision system for creating joint capsulotomies and releasing/incising various tendon and fibrous band structures. The system contains a penetrating needle which is retractable so as to expose a cutting element, and which may be used as a penetrating needle to pierce the skin and other soft tissue structures. The cutting element provided within the penetrating needle may be used to incise subsequent tissue structures after the initial penetration. The system facilitates such procedures by providing the cutting element with the confines of the needle which provides safe introduction of the cutting element directly to the site via the needle.

Abstract: An aspiration control device may include a conduit having a distal end and a proximal end. The conduit may define a conduit lumen and an aperture vent open to the conduit lumen. A coupling may be configured to couple the proximal end of the conduit with a vacuum source and an inner cannula of a tissue cutting device. The inner cannula may define an inner cannula lumen wherein the vacuum source is configured to supply a vacuum to each of the coupling lumen and the inner cannula lumen. A sleeve may be movably disposed about the conduit, and a device motor may be in communication with the sleeve and be configured to move the sleeve to a predefined position relative to the vent in response to an input single from a user interface. The predefined position of the sleeve may correspond to a predefined level of vacuum to be supplied to the inner cannula lumen.

Abstract: A polyp removal device includes an outer tubular body; an inner tubular body; a tubular cutter coupled to or formed as part of the distal end of the inner tubular body; a spring positioned to bias the inner tubular body in an extended direction with respect to the outer tubular body; a handle coupled to the proximal end of the outer tubular body; an actuation member movably coupled to the handle; and a disconnect mechanism for selectively coupling the actuation member to the inner tubular body and decoupling the actuation member from the inner tubular body, the disconnect mechanism is configured to automatically decouple the inner tubular body from the actuation member when the actuation member is moved in a first direction for a distance greater than a predetermined distance.

Abstract: The present invention provides for a removable second stage biocompatible substrate filter that includes biocompatible implant material configured to trap second stage operative particulate matter that may include at least one of bone fragments, plasma, stem cells, cellular matter, and growth factors captured from irrigation fluid. The second stage biocompatible substrate filter may be configured to combine with bone fragments captured from irrigation fluid by a first stage filter and may be configured to be operable with a reaming and collection device.

Abstract: A biopsy device includes coaxially disposed inner and outer needles in which the outer needle tip is configured for obtaining a tissue sample. The inner surface of the outer needle includes a tissue retention feature which may include a countersink and/or a feature formed in the inner surface. The device may be introduced to a biopsy site through an introducer in which the introducer is vented and/or a certain ratio of introducer inner diameter and biopsy device outer diameter is maintained.

Abstract: An assembly including an adapter assembly and an extension assembly for connecting an end effector to an electrosurgical instrument is provided. The adapter assembly includes first and second pusher assemblies configured for converting rotational motion into linear motion and a drive member for transferring rotational motion. The extension assembly includes at least one flexible band assembly for transferring the linear motion from the adapter assembly and a trocar assembly configured for converting rotational motion into linear motion. Also provided is a connection assembly for connecting a first tubular member to a second tubular member.

Abstract: The invention relates to an automatic device for performing skin biopsies, comprising a casing (2) housing a rod (3) on the distal end (3a) of which there is a circular blade (4), and means for causing simultaneous rotation and longitudinal advancement of the rod (3) from a first retracted position wherein the blade (4) of the rod (3) does not project via the distal end (2a) of the casing (2), to a second extended position wherein the blade (4) of the rod (3) projects via the distal end (2a) of the casing, followed by simultaneous rotation and longitudinal retraction of said rod (3) from said second extended position to said first retracted position.

Abstract: A medical power supply system includes: a medical device including an elongated insertion section, a power receiving unit including a power receiving member and movable relative to the insertion section in a longitudinal direction of the insertion section, and a biasing unit biasing the power receiving unit toward a distal end side of the insertion section; and a guide unit including a power transmitting unit including a power transmitting member, the insertion section being inserted into the guide unit. When the insertion section is inserted into the guide unit to a predetermined amount, the power receiving unit comes in contact with the power transmitting unit with being biased by the biasing unit, and the power transmitting member and the power receiving member face each other in an axial direction of the insertion section and have a positional relation in which wireless power transmission is possible.

Abstract: An imaging marker including a body portion having a cavity in the shape of a letter is described. The cavity can be filled with a liquid containing a substance that illuminates during an imaging process. The imaging marker can also include a first end cap and a second end cap. The first end cap can be configured to be placed on a first end of the body portion, and the second end cap can be configured to be placed on a second end of the body portion.

Abstract: An excisional device for either handheld or stereotactic table/MRI use may comprise a work element configured to rotate at a first rotation rate and comprising at least one articulable beak configured to cut tissue in a longitudinal direction. Helical elements or equivalent assemblies may be configured to transport tissue cut by a work element and may be co-axially disposed relative to the work element and may be operative to rotate at rotation rates that may be different from the work element rotation rate. Flush and vacuum tissue transport mechanisms may be incorporated in replacement of or in conjunction with helical elements. A proximal sheath and a distal sheath may be co-axially disposed relative to a work element and may be configured to rotate a work element and to actuate a beak or beaks. A simplified embodiment of this device may be applicable to field use where power sources for actuation may be limited.

Abstract: Disclosed herein is a medical instrument used for harvesting biological tissues of a predetermined biological organ and a medical system. The medical instrument includes: a main body portion that has an elongated shape and has a distal part having a helical groove formed in an outer surface, a fluid lumen through which fluid is allowed to flow and pass, and a through-hole communicating with the fluid lumen and the outer surface of the distal part, at least part of the distal part being stuck into the biological organ; and a tubular member that has an insertion lumen into which the main body portion is inserted movably in axial direction and forms a gap through which fluid is allowed to flow and pass between the main body portion and the tubular member in a state in which the main body portion is inserted in the insertion lumen.

Abstract: An intraocular lens inserter can include a drive device with controllable advance motion. The drive device may include an actuator device and an energy device. The actuator device may include a piston rod that uses the advance motion to push an intraocular lens from a cartridge for insertion into an eye of an animal. The energy device may act upon the actuator device to generate the advance motion. The actuator device may include a dampening medium to control the advance motion, such as by controllably dampening the advance motion.

Abstract: An instrument comprises a shaft assembly. The shaft assembly comprises a first shaft member including a distal cutting feature, and a second shaft member. The first shaft member is slidable relative to the second shaft member. At least a distal portion of the shaft assembly is sized to fit through a nostril. The instrument further comprises a body. At least a portion of the shaft assembly extends distally relative to the body. The body comprises a grounding feature sized and positioned to engage one or more external anatomical structures adjacent to the nostril. The instrument further comprises a dampener. The dampener resists advancement of the first shaft member relative to the second shaft member.

Abstract: A biopsy tool includes an elongated flexible body, a sensor assembly, and a screw member. The sensor assembly is disposed within the elongated flexible body towards the distal end thereof. The sensor assembly includes a location sensor(s) configured to enable detection of a location of the sensor assembly. The screw member is coupled to the distal end of elongated flexible body, extends distally from the elongated flexible body, and is positioned distally of the sensor assembly. The screw member defines a helical configuration having a hollow interior and is configured for simultaneous rotation relative to tissue and advancement into tissue to obtain a tissue sample.

Abstract: A notched tissue-collection needle configured similarly to a fine-needle-aspiration needle is provided with a cutting edge disposed in the notch and configured to excise tissue into the notch for collection. A stylet may be provided through a lumen of the needle during introduction into a patient body. The needle may be provided with echogenicity-enhancing features.

Abstract: A biopsy system includes an endoscope which includes an insertion portion having a channel, and a bendable portion provided in a distal end portion of the insertion portion; a needle tube which includes a distal end region, and a proximal end region having a higher bending rigidity than that of the distal end region; a sheath which can be inserted into the channel and inserted through by the needle tube; an attachment adapter which is provided on a proximal end side of the sheath and is capable of being mounted at the endoscope; and a connection member which connects the distal end region and the proximal end region, wherein the connection member can move within only a range of the insertion portion more proximal than a proximal end of the bendable portion and more distal than a proximal end of a follow-bending region.

Abstract: An instrument for delivering a suture transfascially may include a handle, a shaft extending from the handle, and at least one needle that is moveable to an extended position beyond the end of the shaft. A suture may be delivered transfascially with the instrument. The instrument may include a suture catch associated with each needle for retaining and releasing a suture segment. A shield may be provided to shield the sharp end of each needle when it is moved to the extended position. A method of delivering a transfascial suture may include inserting an instrument into an abdominal cavity and deploying, from within the abdominal cavity, each needle through a soft tissue repair patch and then through at least part of the abdominal wall. A suture or suture segment may be advanced across the fascia with the at least one needle.

Abstract: Devices and methods for delivering substances to lung tissue through an extra-anatomic passage created in an airway.

Abstract: A novel neural injection system and related methods are herein disclosed. Various embodiments of an embodiment of a neural injection system of the present invention provide for at least one benefit of enhanced injection characteristics, increased operational efficiency, reduced cost per unit, reduced incidence of injury through intraneural/intravascular injection, reduced incidence of injury through pricking/piercing, and/or the like.

Abstract: A biopsy device comprises a needle, a body portion, and a needle firing assembly. The needle firing assembly is operable to fire the needle distally relative to the body portion. The needle firing assembly includes two translating members, a resilient member, and a motor. The motor is operable to selectively move the first translating member distally and proximally. The second translating member is secured relative to the needle such that the needle and the second translating member translate unitarily. The resilient member compresses as the first translating member is moved distally toward the second translating member. The first translating member is then secured to the second translating and the translating members are moved proximally while holding the resilient member in the compressed state. The second translating member is released from the first translating member when they reach a proximal position, which allows the resilient member to fire the needle distally.

Abstract: A novel neural injection system and related methods are herein disclosed. Various embodiments of an embodiment of a neural injection system of the present invention provide for at least one benefit of enhanced injection characteristics, increased operational efficiency, reduced cost per unit, reduced incidence of injury through intraneural/intravascular injection, reduced incidence of injury through pricking/piercing, and/or the like.

Abstract: A handle for a medical device comprises a proximal segment defining a proximal lumen extending therethrough and sized and shaped to receive an endoscopic medical device therein. A medial segment is received within a distal portion of the proximal segment and has an outer diameter smaller than an inner diameter thereof. A medial lumen extends through the proximal segment and is open to the proximal lumen. A distal segment is received within a distal portion of the medial segment and defines a distal lumen extending therethrough open to the medial lumen. The distal segment has an outer diameter smaller than an inner diameter of the medial segment. The medial segment includes a first movement limiting mechanism limiting movement of an endoscopic medical device inserted therethrough along an axis of the distal lumen and a second movement limiting mechanism limiting advancement of an endoscope attached to the distal body portion.

Abstract: A biopsy device for acquiring a tissue sample is disclosed. The biopsy device comprises a partoff mechanism which can have at least a tab and an actuator. The actuator can be used to control the angle of the tab and thus partoff a tissue sample. The tab may be on a cutter tube, which may have a sharp distal end which may core the samples from the mass of tissue. Multiple tissue samples may be collected.

Abstract: A biopsy assembly includes a biopsy device, a vacuum source, and a valve assembly. The biopsy device includes a body, a needle extending distally from the body, and a cutter translatable relative to the needle. The needle includes a lateral tissue receiving aperture. The cutter is translatable to selectively close the lateral tissue receiving aperture of the needle. The valve assembly is in fluid communication with the needle. The valve assembly includes a first valve, a second valve, and tubular member. Each of the first valve and the second valve selectively provide atmospheric venting or vacuum to the needle. The tubular member is coupled with the vacuum source and includes a first and second connector extending transversely from the tubular member. The first and second connectors couple to the first and second valves to provide vacuum to the first and second valves.

Abstract: Biopsy devices (10, 10?) for acquiring tissue samples (59). In embodiments, exemplary biopsy devices include a cutter (127), a cannula (13) including a tissue-receiving cavity (42), a vacuum generating mechanism (17) and a tissue cutting mechanism (15). Vacuum generating mechanism draws tissue (47) into tissue-receiving cavity and tissue cutting mechanism cuts a tissue sample (59). Vacuum generating mechanism may provide positive air pressure for tissue sample ejection.

Abstract: A surgical kit for preparing a joint surface to receive an implant includes a patient-specific guide for a joint surface. The patient-specific guide has a patient-specific surface complementary to a surface of the joint for nesting engagement, and a guiding element oriented along a patient-specific alignment axis. The alignment axis is determined during a preoperative plan of the specific patient for implant alignment. The kit includes a guiding tool couplable to the guiding element of the patient-specific guide and a three-dimensional orientation device removably couplable the guiding tool for intra-operative calibration, such that, after calibration, the orientation device can be removably coupled to a shaft of a surgical instrument to align the shaft along the alignment axis.

Abstract: One embodiment of a multifunction aspiration biopsy device includes a hub having a chamber for receiving a collected specimen, a vacuum source in communication with the hub chamber, a needle detachable from the hub and having an outlet in communication with the hub chamber, and a cover extending over a portion of the needle outlet for directing a specimen collected through the needle into the hub chamber in a direction that differs from a longitudinal axis of the needle. The hub chamber with collected specimen may be separated from the vacuum source and the needle and the specimen may be triaged within the hub chamber. Various embodiments of a collection container for receiving used needles are also disclosed.

Abstract: A method and device for the treatment of hypertrophic cardiomyopathy. The device includes a cutting device for resection of a thickened myocardium. The operator positions the cutting device adjacent to the myocardium that is to be resected and then slides a tubular blade within an outer shell of the cutting device to resect the septum.

Abstract: A biopsy device includes a vacuum source, and an elongate member having a lumen and a sample receiving notch. The sample receiving notch has a proximal hole, a distal end wall, and a floor. The proximal hole is separated from the distal end wall along the longitudinal axis. The proximal hole is in fluid communication with the lumen. A tissue anchor has a cantilever portion with a free end. The cantilever portion is configured to extend in a direction from the distal end wall toward the proximal hole. The free end has a tip portion configured to extend toward the floor. The tissue anchor and the proximal hole are collectively configured to place tissue received in the sample receiving notch in a state of tension between the tip portion and the proximal hole when a vacuum is applied by the vacuum source to the proximal hole via the lumen.

Abstract: A biopsy device may include a needle, a cutter, and a handpiece. A vacuum pump in the handpiece may provide a vacuum to the needle and/or to the cutter. A pressure pump in the handpiece may also provide pressurized air to the needle and/or to the cutter. A motor in the handpiece may drive the vacuum pump, the pressure pump, and/or the cutter. A vacuum sensor may sense a vacuum level within the biopsy device, and cause initiation of operational cycles in response to sensed vacuum levels. Portions of a valving mechanism and a clutching mechanism may be integrally formed. A clutching and valving mechanism may be driven by a first battery-powered motor; and a cutter, pressure pump, and vacuum pump by a second battery-powered motor. A biopsy device may thus provide vacuum, pressurized air, and power from within a handpiece, such that the biopsy device is tetherless.

Abstract: A differential dissecting instrument for differentially dissecting complex tissue is disclosed. The differential dissecting instrument comprises a handle and an elongate member having a first end and a second end, wherein the first end is connected to the handle. The differential dissecting instrument comprises a differential dissecting member configured to be rotatably attached to the second end and further comprises at least one tissue engaging surface. The differential dissecting instrument comprises a mechanism configured to mechanically rotate the differential dissecting member around an axis of rotation, thereby causing the at least one tissue engaging surface to move in at least one direction against the complex tissue. The at least one tissue engaging surface is configured to selectively engage the complex tissue such that the at least one tissue engaging surface disrupts at least one soft tissue in the complex tissue, but does not disrupt firm tissue in the complex tissue.

Abstract: Vitrectomy probes and system related thereto are disclosed herein. The disclosure describes vitrectomy probes having an adjustable cutting port size. The cutting port size may be adjusted by altering a position of a stroke limiter via a stepper motor. Various example features are described for adjusting the size of the cutting port.

Abstract: A biopsy needle comprises a first lumen open to a tissue penetrating distal tip of the needle for receiving a tissue sample therein and a second lumen in combination with a filter separating the first and second lumens from one another, the filter being configured to permit fluids to pass therethrough while preventing the sampled tissue from passing therethrough.

Abstract: A biopsy device includes coaxially disposed inner and outer needles in which the outer needle tip is configured for obtaining a tissue sample. The inner surface of the outer needle includes a tissue retention feature which may include a countersink and/or a feature formed in the inner surface. The device may be introduced to a biopsy site through an introducer in which the introducer is vented and/or a certain ratio of introducer inner diameter and biopsy device outer diameter is maintained. The full core devices also permit a tighter tolerance between the I.D. and O.D. of the outer cannula and stylet, respectively, which further permits the use of a smaller gage introducer. Full devices also include a sample trap assembly operable to enlarge the sample cavity after the full core sample has been obtained.

Abstract: A method for operating a biopsy device to acquire at least one tissue sample from a body of a living being, including retracting a sample-receiving device through a hollow needle to a sample removal position, a tissue sample being simultaneously transported to the sample removal position by the sample-receiving device; operatively connecting a liquid supply unit to a cavity of the sample-receiving device when the sample-receiving device is at the sample removal position; and delivering a lateral flow of a flushing liquid from the liquid supply unit to the cavity of the sample-receiving device to facilitate a lateral tissue sample ejection from the cavity.

Abstract: A system and method is provided for an injectable substance delivery device comprising a limiter, shoulder or post that controls how deep the needle is inserted into the tissue. The limiter is sized in proportions that control the maximum insertion depth of the needle into the tissue without excessively restricting the complete insertion of the needle. The system and method further comprises an normalization or stabilizer ring that prevents distortion of the tissue in the vicinity of the infusion, so that the needle length is the major determining factor as to how deep the infusion is delivered.

Abstract: A method of operating a biopsy device includes inserting a sampling probe having a first component and a second component into a biological tissue mass, the first component having a sample chamber and a side port that opens to the sample chamber, and the second component having a side opening; generating a vacuum in the sample chamber during a first drive interval; rotating at least one of the first component and the second component of the sampling probe during a second drive interval until the side port of the first component and the side opening of the second component are in radial alignment; and rotating at least one of the first component and the second component of the sampling probe during a third drive interval to sever tissue drawn by vacuum into the sample chamber to deposit a tissue sample in the sample chamber.

Abstract: A biopsy system includes a biopsy device and a vacuum control module. The biopsy device includes a cannula and a cutter that translates relative to the cannula to obtain tissue samples. The vacuum control module includes a source of vacuum in communication with the cutter and a user interface. The user interface includes a first page and a second page. The first page has a first graphical representation to indicate the operational status of the biopsy device and does not accept user inputs to alter the operational status of the biopsy device. The second page has at least one icon to adjust the operational status of the biopsy device indicated on the first page and a second graphical representation to indicate the adjustment to the operational status of the biopsy device. The user interface includes a user input feature to select the first page or the second page.

Abstract: An embodiment of the present invention provides a kit of parts for use in a surgical procedure performed under image guidance, and particularly under real time image guidance. The kit includes a sterilized drape for use with the chosen imaging machine and which can be used to provide a sterile operating environment when the procedure is performed under the imaging beam. The kit also includes a needle holder that can keep the surgeon's hand away from the imaging beam. The needle holder is operable to hold a needle that is made from a material suitable for piercing tissue, but also substantially preserves the appearance of the needle when it is viewed under the imaging beam.

Abstract: Intraosseous needle sets (e.g., cannulas and stylets) and kits comprising the same, such as those, for example, having a non-circular bore and configured to receive a sample from a target area (e.g., a cortex, a sternum, a humerus, and/or the like).