Seeds Patents (Class 600/8)
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Patent number: 8771162Abstract: A spacer for use in brachytherapy, and radiotherapy, is formed of an encapsulating material in a generally cylindrical or elongated shape. Regions are formed within the spacer and retaining therapeutic loads, such as radiation sources and/or pharmaceutical therapeutic loads, and/or any other substances to treat a patient, such as drug liquids, powder or particles (e.g., microparticles or nanoparticles), with the particles or powders combined with binders, such as polyacrylamide, that are selected to gradually disperse the powder or particles at a desired rate. Such regions can be formed at various locations within the spacer, and can have various shapes depending on the particular design and intended usage. The outer surface of the encapsulating material can optionally include one or more fins, ribs or other physical protuberances or features that improve the fixity of the spacer when implanted within a patient's body.Type: GrantFiled: December 8, 2010Date of Patent: July 8, 2014Assignee: Eckert & Ziegler Bebig S. A.Inventors: Gary A. Lamoureux, Warren Johnston, Lino Costantini
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Publication number: 20140179979Abstract: The present application relates to applicators and methods for administering therapeutic agents to cancerous tissue. The applicators can be used to deliver radiation and additional therapeutic agents to cancerous tissue located in a subject.Type: ApplicationFiled: June 21, 2012Publication date: June 26, 2014Applicants: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., UNIVERSITY OF SOUTH FLORIDAInventors: Steven E. Finkelstein, Matthew C. Biagioli, Mayer N. Fishman
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Patent number: 8702579Abstract: A needle holder device for treating the prostate, involving a series of steps of inserting a needle into the prostate, has a rectal probe for ultrasonic 3D imaging and a computer for processing the image acquired by the probe and for computing the position of the needle relative to the prostate. The computer is controlled so as to periodically output information on the movement of the prostate after each of the insertion steps in order to validate the insertion parameters relative to a treatment schedule and, if need be, modifying the insertion parameters relative to the schedule in the event the movement is greater than a threshold value.Type: GrantFiled: August 27, 2010Date of Patent: April 22, 2014Assignees: Koelis, Universite Joseph FournierInventors: Michael Bauman, Nikolai Hungr, Antoine Leroy, Jocelyne Troccaz, Vincent Daanen
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Patent number: 8696540Abstract: According to one general aspect there is a needle package apparatus that comprises a top portion and a bottom portion; a plurality of needle slots exact distance apart that allows to place a plurality of needles that contain radioactive seeds; a cylindrical coil that is inserted to the plurality of needle slots to hold said plurality of needles, wherein said cylindrical coil prevents the leakage of the radiation from the radioactive seeds; a set of hinges located at the end of said needle package within the outer most said plurality of needle slots; wherein the hinges can be bend to change the angle of said top portion of said needle package by a medical personnel to create a stand; and a single end enclosure located at the distal end of said cylindrical coil to provide an enclosed cylinder.Type: GrantFiled: April 5, 2011Date of Patent: April 15, 2014Assignee: Best Medical International, Inc.Inventors: Rohit Mehta, Rashmi Amin
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Patent number: 8641592Abstract: A method and device for image guided dynamic radiation treatment of prostate cancer and other pelvic lesions including: 1) a unique fan geometry of radiation sources; 2) a special collimation method and apparatus to sculpt the radiation borders; 3) an integrated three-dimensional imager and a special tissue interface imaging system to locate and track critical boundaries in real-time; 4) a dynamic patient support system, which is shared by the said imager and the irradiation system; and 5) motorized custom shielding filters to further protect neighboring normal tissues such as the kidneys and femoral heads. The fan geometry utilizes a plural number of radiation sources arranged specifically for irradiating tumors in the human pelvis while not harming critical structures, and the collimation sculpts the radiation borders using motorized shields for different sensitive structures.Type: GrantFiled: March 23, 2010Date of Patent: February 4, 2014Inventor: Xinsheng Yu
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Publication number: 20140018607Abstract: A method for generating a treatment plan for therapy comprising obtaining image data representing a tissue, determining a therapy dose map comprising dose values for a plurality of dose points based on the image data, forming a desired dose value vector comprising the dose values for the plurality of dose points, determining a one or more potential therapy locations based on the image data, determining a therapy dose map equation for each of the plurality of dose points based on the one or more potential therapy locations, forming a matrix based on the therapy dose map equations for the each dose points, determining an inverse of the matrix and determining the treatment plan by multiplying the desired dose value vector by the inverse of the matrix.Type: ApplicationFiled: December 17, 2012Publication date: January 16, 2014Applicant: HOLOGIC, INC.Inventor: HOLOGIC, INC.
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Publication number: 20130338423Abstract: A device for loading and customizing brachytherapy carriers based on the principles of optimizing a more precise and predictable dosimetry, and adaptable to the geometric challenges of a tumor bed in a real-time setting. The present invention relates to a specialized loading device designed to enable a medical team to create a radionuclide carrier for each patient and tumor reliably, reproducibly and efficiently.Type: ApplicationFiled: April 30, 2012Publication date: December 19, 2013Inventors: Peter Nakaji, David Brachman, Heyoung McBride, Emad Youssef, Theresa Thomas
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Patent number: 8567410Abstract: The present invention relates to aerosols containing magnetic particles, wherein the aerosols comprise magnetic particles and a pharmaceutical active agent. The invention furthermore relates to the use of such aerosols containing magnetic particles for directed magnetic field-guided transfer of the active agents contained therein in aerosol therapy.Type: GrantFiled: August 25, 2006Date of Patent: October 29, 2013Assignee: Ethris GmbHInventors: Carsten Rudolph, Joseph Rosenecker
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Patent number: 8545377Abstract: A magazine for chain components of a chain with radiation sources comprises a housing as well as a first means for receiving chain components that is mounted in a pivotal manner in the housing and has recesses for receiving the chain components, a tension spring for driving the means for receiving the chain components, a sprocket being coupled in a pivotal manner to the means for receiving the chain components and being mounted in a pivotal position in the housing, and an ejector for ejection of the radiation sources. Furthermore, the magazine comprises an ejection lever which is mounted in a pivotal manner in the housing, whereby, in a first position, the ejection lever engages the sprocket, and in a second position it blocks the ejector.Type: GrantFiled: February 11, 2011Date of Patent: October 1, 2013Assignee: Eckert & Ziegler Bebig GmbHInventors: Axel Hentrich, Christoph Lederer
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Publication number: 20130253255Abstract: The invention provides for a brachy-therapy seed, wherein the seed includes at least two disparate radionuclides of a chemical element, the radionuclides encapsulated to form a brachytherapy seed and wherein the combination of the disparate radionuclides of the chemical element is used to augment dosimetric parameters and radiobiological characteristics of the brachytherapy seed. The invention also provides a method of manufacturing a brachytherapy seed that includes the steps of bombarding elemental silver with high energy protons produced by a cyclotron to obtain a target of 100 Pd and 103 Pd; dissolving and passing the target through a column of resin beads; placing at least one resin bead having adsorbed 100 Pd and 103 Pd into a titanium tube that is closed at one end; inserting a radiopaque member into the titanium tube; and closing the opposite end of the titanium tube.Type: ApplicationFiled: November 17, 2011Publication date: September 26, 2013Applicant: NORTHERN ONCOLOGY (PTY) LTDInventor: Wayne Van Niekerk
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Publication number: 20130217952Abstract: A flexible endoscope for ophthalmic orbital surgery includes a flexible probe housing having a proximal end, a distal end and a lumen extending between the proximal end and the distal end. The endoscope also includes an image fiber disposed in the lumen that communicates image information from the distal end of the flexible probe, a purge fluid/gas port disposed at the proximal end of the flexible probe that accepts purge fluid/gas and a purge fluid/gas conduit disposed in the lumen and in fluid communication with the purge fluid/gas port. The fluid/gas conduit delivers purge fluid/gas to the distal end of the endoscope. The endoscope also includes an access conduit disposed in the lumen that receives one of an ablation instrument, a coagulating instrument and a medication delivery instrument.Type: ApplicationFiled: March 21, 2013Publication date: August 22, 2013Applicant: VANDERBILT UNIVERSITYInventor: VANDERBILT UNIVERSITY
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Publication number: 20130204072Abstract: A brachytherapy method and apparatus include implanting an applicator having at least one radiation source or seed receiving channel (62) into soft tissue adjacent a target region (40) to be irradiated. A high resolution planning image (64) of the target region including the applicator is generated, wherein the high resolution planning image is used for determining a three-dimensional treatment plan (66). A position of the applicator is tracked relative to the target region (40) and the treatment plan (66). Tracking the position includes measuring, via shape-sensing, a location and shape of the at least one radiation source or seed receiving channel (62).Type: ApplicationFiled: November 17, 2010Publication date: August 8, 2013Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Laurent Verard, Luis Felipe Gutierrez, Dirk Binnekamp
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Patent number: 8500693Abstract: The present invention relates to a device for automatic injection of a product, comprising: a body (3) housing a container, the container being movable relative to said body between an initial position, to an insertion position; a safety shield (26) movable with respect to said container and said body between an insertion position to a protection position, when the user removes the device from an injection site; an external socket (48) receiving the body and provided with selection means (53) which can be placed by a user: either in a first position, in which the body (3) and the external socket (48) are bound to each other, the safety shield extending beyond the distal end of both said body and said external socket in the protection position; or in a second position, in which the external socket (48) is able to move axially in the distal direction with respect to the body (3), both the safety shield and the external socket extending beyond the distal end of said body, in the protection position.Type: GrantFiled: September 25, 2007Date of Patent: August 6, 2013Assignee: Becton Dickinson FranceInventor: Lionel Maritan
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Publication number: 20130190549Abstract: A point-of-care seed stranding device for automating assembly of brachytherapy seed strands for implantation in patients. The device includes a number of features to reduce the potential for mistakes by the user, as well as to reduce the potential for damaging the radioactive seeds during the stranding process. Tactile feedback may be provided to prevent exertion of too much force in the packing step of the stranding process, as well as to indicate that the seed and/or strand cartridges are empty and need to be replaced. The device may also include a mechanism for holding seeds or spacers in place to allow automated packing of seeds or spacers having corresponding geometries. The device may also be provided with a seed counter which can be employed to preset the number of seeds in a strand and which disables the device from dispensing or packing additional seeds once the preset number of seeds has been packed into the strand.Type: ApplicationFiled: January 3, 2013Publication date: July 25, 2013Applicant: THERAGENICS CORPORATIONInventor: THERAGENICS CORPORATION
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Patent number: 8454489Abstract: The present disclosure relates to an implant comprising at least two sheets of a biocompatible material, and at least one radioactive seed disposed between said sheets of material. The disclosure also relates to a method for treating a patient, comprising fixing to the tissue of the patient at least one implant comprising at least two sheets of a biocompatible material, and at least one radioactive seed disposed between said sheets of material.Type: GrantFiled: March 14, 2007Date of Patent: June 4, 2013Inventors: Michael W. Drobnik, Christopher D. Drobnik
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Publication number: 20130131434Abstract: Brachytherapy radioisotope carrier systems and methodology for providing real-time customized brachytherapy treatment to subjects with tumors difficult to control using conventional radiation therapy techniques. The invention generally relates to devices, methods and kits for providing customized radionuclide treatments, to help cure, slow progression or regrowth, or ameliorate the symptoms associated with tumors.Type: ApplicationFiled: April 30, 2012Publication date: May 23, 2013Inventors: Peter Nakaji, David Brachman, Heyoung McBride, Emad Youssef, Theresa Thomas
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Patent number: 8430804Abstract: Methods and devices for minimally-invasive delivery of radiation to the posterior portion of the eye including a cannula comprising a distal portion connected to a proximal portion and a means for advancing a radionuclide brachytherapy source (RBS) toward the tip of the distal portion; a method of introducing radiation to the human eye comprising inserting a cannula between the Tenon's capsule and the sclera of the human eye and emitting the radiation from the cannula on an outer surface of said sclera.Type: GrantFiled: January 7, 2009Date of Patent: April 30, 2013Assignee: Salutaris Medical Devices, Inc.Inventors: Luca Brigatti, Russell J. Hamilton, Laurence J. Marsteller, Michael Voevodsky
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Publication number: 20130102832Abstract: A brachytherapy device includes a bioabsorbable support and a plurality of microcapsules on the support. Each of the plurality of the microcapsules includes a plurality of microspheres and a bioabsorbable microcapsule wall that encloses the plurality of microspheres. The plurality of microspheres includes radiation-emitting microspheres comprising a radioactive material, radio-opaque microspheres comprising a radio-opaque material or a combination thereof.Type: ApplicationFiled: August 24, 2012Publication date: April 25, 2013Inventors: Seth A. Hoedl, Bruce Kitzman
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Publication number: 20130102891Abstract: A system and methods for adaptive placement of a treatment element include a placement device (134), and a localization system (120) configured to track progress of the placement device such that a position of a treatment element (146, 132) placed by or to be placed by the placement device is stored in memory. A computer system (142) includes a program (104) implemented in computer readable storage media and configured to compute an effect of the treatment element at the position and determine whether a dosage amount has been achieved by the treatment element for treatment of an organ.Type: ApplicationFiled: May 27, 2011Publication date: April 25, 2013Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Dirk Binnekamp, Luis Felipe Gutierrez, Neil David Glossop, Jochen Kruecker, Shriram Sethuraman
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Publication number: 20130046128Abstract: A radiotherapy delivery device is provided comprising an elongated applicator having a proximal end and a distal end having a tip. The distal end is adapted to be introduced into a body including a treatment zone to be located adjacent a target tissue. A radiotherapy emitter is provided that is moveable between the proximal end of the applicator and the treatment zone of the applicator. The applicator includes a window to permit visual confirmation of the location of the radiation emitter and the treatment zone.Type: ApplicationFiled: October 17, 2012Publication date: February 21, 2013Applicant: NEOVISTA, INC.Inventor: NeoVista, Inc.
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Publication number: 20130035537Abstract: A method of manipulating an elongate member in at least two degrees of freedom includes holding an elongate member between two rotary members that define respective rotational axes, the elongate member having a flexible proximal portion, a distal rigid needle attached to the proximal portion, and an operative element for delivering energy, the needle having a distal port, actuating at least one of the rotary members in a rotational direction about its rotational axis to generate a corresponding linear motion of the elongate member along a longitudinal axis of the elongate member, and actuating at least one of the rotary members in a linear direction along its rotational axis to generate a corresponding rotational motion of the elongate member about the longitudinal axis of the elongate member.Type: ApplicationFiled: December 2, 2011Publication date: February 7, 2013Inventors: Daniel T. Wallace, Dale Bergman, Ruchi Choksi, Aaron Grogan
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Patent number: 8366598Abstract: A therapeutic strand implant, for use in brachytherapy and deliverable to an implant site by way of a needle, includes a plurality of radioactive sources, and a polymeric material molded to encapsulate the radioactive sources. A space is defined by the polymeric material between each adjacent pair of the radioactive sources. A plurality of protrusions is defined by an outer surface of the encapsulating polymeric material.Type: GrantFiled: August 18, 2011Date of Patent: February 5, 2013Assignee: Biocompatibles UK LimitedInventors: Gary A. Lamoureux, James Matons, Warren W. Johnston, Matthew Bouffard, Warren Rice
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Patent number: 8366597Abstract: A device is proposed for assembling chain components to a chain, wherein at least two chain components include radioactive radiation sources. The device includes a housing, a working channel which extends along a first axis of the housing, a loading unit connected to the working channel and having at least two receiving devices for chain component magazines, wherein at least one receiving device is configured to receive a radiation source magazine, as well as at least one means for ejecting the chain components received from the magazines, and an joining unit for joining chain components. The at least two receiving devices are positioned so that the magazines for chain components received therein are spaced along the first axis and positioned vertically above the working channel.Type: GrantFiled: February 11, 2011Date of Patent: February 5, 2013Assignee: Eckert & Ziegler Bebig GmbHInventors: Axel Hentrich, Christoph Lederer
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Patent number: 8323172Abstract: Methods of forming a low-dose-rate (LDR) brachytherapy device include depositing a solution comprising a soluble form of a radioactive material on a substrate. A water-insoluble form of the radioactive material is formed on the substrate by chemical precipitation and/or thermal decomposition.Type: GrantFiled: May 1, 2009Date of Patent: December 4, 2012Assignee: Civatech OncologyInventors: Robert D. Black, David Wagner, Claudia Black
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Publication number: 20120277519Abstract: According to one general aspect there is a needle package apparatus that comprises a top portion and a bottom portion; a plurality of needle slots exact distance apart that allows to place a plurality of needles that contain radioactive seeds; a cylindrical coil that is inserted to the plurality of needle slots to hold said plurality of needles, wherein said cylindrical coil prevents the leakage of the radiation from the radioactive seeds; a set of hinges located at the end of said needle package within the outer most said plurality of needle slots; wherein the hinges can be bend to change the angle of said top portion of said needle package by a medical personnel to create a stand; and a single end enclosure located at the distal end of said cylindrical coil to provide an enclosed cylinder.Type: ApplicationFiled: April 5, 2011Publication date: November 1, 2012Inventors: Rohit Mehta, Rashmi Amin
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Publication number: 20120259153Abstract: Delivery systems adapted for implementation during a brachytherapy procedure are provided. The delivery system includes a plurality of brachytherapy seeds and a plurality of spacers. Each spacer is formed of a matrix material carrying a plurality of microparticles and/or nanoparticles. The microparticles and/or nanoparticles carry an agent and are biodegradable and/or biocompatible. The brachytherapy seeds and the spacers are configured to be delivered to a target site. Associated methods are also provided.Type: ApplicationFiled: October 20, 2010Publication date: October 11, 2012Applicant: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILLInventors: Zhuang Wang, Michael Edward Werner, James Donald Byrne, Ronald Chingyun Chen, Shrirang Shrikant Karve, Joseph DeSimone
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Publication number: 20120253100Abstract: Braces to reduce bending of a brachytherapy needle during insertion into a patient, as well as methods of using the needle braces and kits useful therefor.Type: ApplicationFiled: December 22, 2010Publication date: October 4, 2012Inventors: Robert F. Chisholm, Jay Reed, Kevin Helle
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Publication number: 20120142993Abstract: The present invention provides a method for large scale production of cesium-131 (Cs-131) with low cesium-132 (Cs-132) content, where the Cs-131 is produced via barium-131 (Ba-131) decay. Uses of the Cs-131 produced by the method include cancer research and treatment, such as for use in brachytherapy. Cesium-131 is particularly useful in the treatment of faster growing tumors.Type: ApplicationFiled: February 27, 2007Publication date: June 7, 2012Applicant: IsoRay Medical, Inc.Inventors: Sergey Zlokazov, David J. Swanberg, Oleg Egorov, Garrett N. Brown, Dale E. Boyce
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Patent number: 8192345Abstract: In an embodiment, a brachytherapy device includes a cartridge adapted for use with a brachytherapy applicator. A plurality of therapeutic members are stacked parallel to one another within the cartridge. Each therapeutic member includes a radioactive seed that is at least partially encapsulated by a polymeric material. Additionally, each therapeutic member can include at least one protrusion on an outer surface of the encapsulating polymeric material to reduce a tendency for the therapeutic member to migrate and rotate within a patient's body after the therapeutic member is implanted.Type: GrantFiled: January 21, 2009Date of Patent: June 5, 2012Assignee: Biocompatibles, UKInventors: Gary A. Lamoureux, James Matons, Warren W. Johnston, Matthew Bouffard, Warren Rice
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Patent number: 8187159Abstract: A therapeutic member for use in brachytherapy deliverable to an implant site by way of a needle comprises a single radioactive source encapsulated by a bio-absorbable material having an outer surface including one or more ribs encircling the single radioactive source, a leading edge endcap rib and a trailing edge endcap rib. The one or more ribs reduces a tendency of the member to migrate and rotate within a patient's body after implantation. The encapsulating material further includes a first rail formed from the bio-absorbable material extending at least from opposite sides of the outer surface of the encapsulating material along the longitudinal axis of the therapeutic member, and a second rail formed from the bio-absorbable material extending at least from opposite sides of the outer surface of the encapsulating material along the longitudinal axis of the therapeutic member, the second rail arranged in a plane substantially perpendicular to a plane in which the first rail is arranged.Type: GrantFiled: February 26, 2009Date of Patent: May 29, 2012Assignee: Biocompatibles, UKInventors: Gary A. Lamoureux, James Matons, Warren Johnston, Matthew Bouffard, Warren Rice
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Publication number: 20120123189Abstract: An oncology therapy method comprises implanting a radioactive seed (10, 20, 30, 40, 50) in an oncology subject (S). In some embodiments the radioactive seed comprises a radioactive material (12, 32, 33, 42) including at least one radioisotope disposed in a biodegradable host (14, 24, 25, 44) configured to biodegrade over a therapy time period when implanted in the oncology subject. In some embodiments the radioactive seed is implanted in soft tissue of an oncology subject (S), and the radioactive seed comprises a radioactive material (12, 32, 33, 42) including at least one radioisotope disposed in a host material (14, 24, 25, 44) having softness comparable with or softer than the soft tissue into which the radioactive seed is implanted.Type: ApplicationFiled: July 6, 2010Publication date: May 17, 2012Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Carolina Ribbing, Michael Overdick
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Publication number: 20120108882Abstract: A brachytherapy device includes a sealed housing having a radioactive material therein, and at least one shielding member extending away from the housing and configured to provide radiation shielding on at least one side of the housing.Type: ApplicationFiled: November 1, 2011Publication date: May 3, 2012Inventor: Seth A. Hoedl
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Patent number: 8140169Abstract: An induction heating apparatus includes a first interventional device and a second interventional device. The first interventional device includes an electrically conductive material. The first interventional device is adapted for implantation inside a body and for receiving an alternating current. The second interventional device comprises a magnetically conductive material. The second interventional device is adapted for implantation inside the body in close proximity to the first interventional device. With both devices placed inside the body, the second interventional device magnetically couples with the first interventional device and the second interventional device generates heat upon the application of the alternating current to the first interventional device thereby heating the body site.Type: GrantFiled: April 5, 2005Date of Patent: March 20, 2012Assignee: Boston Scientific Scimed, Inc.Inventors: Barry N. Gellman, Jozef Slanda, Kimberly Paddock
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Publication number: 20120065454Abstract: Bracytherapy devices include a respective tether attached to a proximal end portion of the strands. The tether can be color-coded to match a color associated with the corresponding strand.Type: ApplicationFiled: August 3, 2011Publication date: March 15, 2012Inventors: Andrew Karim Kader, Daniel B. Fried
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Patent number: 8114007Abstract: In an embodiment a therapeutic member includes a solitary radioactive seed. The seed includes a metallic housing with radioactive material contained within the metallic housing. The metallic housing has a first longitudinal end and a second longitudinal end and a longitudinal length between the first and second longitudinal ends. A polymeric material is molded to completely and monolithically encapsulate the metallic housing of the solitary radioactive seed. The implantable therapeutic member is adapted to be implanted into patient tissue using a hollow needle. A portion of the molded polymeric material extends from one of the first and second longitudinal ends of the metallic housing to reduce a tendency of the seed to migrate and rotate within a patient's body after implantation of the member.Type: GrantFiled: December 15, 2008Date of Patent: February 14, 2012Assignee: Biocompatibles UK LimitedInventors: Gary A. Lamoureux, James Matons, Warren W. Johnston, Matthew Bouffard, Warren Rice
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Publication number: 20120016176Abstract: A therapeutic strand implant, for use in brachytherapy and deliverable to an implant site by way of a needle, includes a plurality of radioactive sources, and a polymeric material molded to encapsulate the radioactive sources. A space is defined by the polymeric material between each adjacent pair of the radioactive sources. A plurality of protrusions is defined by an outer surface of the encapsulating polymeric material.Type: ApplicationFiled: August 18, 2011Publication date: January 19, 2012Applicant: BIOCOMPATIBLES, INC.Inventors: Gary A. Lamoureux, James Matons, Warren Johnston, Matthew Bouffard, Warren Rice
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Patent number: 8066627Abstract: A delivery system and method for interstitial radiation therapy comprising substantially axially stiff and longitudinally flexible elongated members made of material which is bioabsorbable in living tissue and a plurality of radioactive seeds dispersed in a predetermined array within the elongate member. The radioactive seeds can be dispersed within assembled half-shells made of the same material. The housing for the radiation seeds can also be manufactured from extruded material. A system for manufacturing the interstitial radiation therapy seed strands that automatically makes the seed strands at the patient's bedside. The delivery system and method further customize the member based on a prescription.Type: GrantFiled: June 16, 2006Date of Patent: November 29, 2011Assignee: Biocompatibles UK LimitedInventors: Richard A. Terwilliger, Gary A. Lamoureux
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Patent number: 8033981Abstract: A radioactive member for use in brachytherapy comprising a molded elongate, bioabsorbable carrier material with spaced radioactive sources disposed therein, and methods for the manufacture thereof. The radioactive members may be used in the treatment of, for example, prostate cancer.Type: GrantFiled: June 15, 2009Date of Patent: October 11, 2011Assignee: Medi-Physics, Inc.Inventors: Michael Rapach, Kevin Helle, Charles E. Shanks, Jay Christopher Reed
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Patent number: 8021291Abstract: In an embodiment, an implantable marker, which is adapted to be implanted into patient tissue using a hollow needle, includes a marker body including a radiopaque material and a polymeric material that encapsulates at least a portion of the marker body. In an embodiment, an outer surface of the encapsulating material includes one or more protrusions to reduce a tendency of the marker to migrate and rotate within a patient's body after implantation.Type: GrantFiled: January 21, 2009Date of Patent: September 20, 2011Assignee: Biocompatibles UK LimitedInventors: Gary A. Lamoureux, James Matons, Warren W. Johnston, Matthew Bouffard, Warren Rice
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Patent number: 8012455Abstract: The present invention provides an integral source material, the integral source material has at least one nuclide that is an integral source material having at least one nuclide that is activatable by exposure to radiation, the nuclide is a chemically bound constituent of a polymer of the integral source material, wherein the integral source material is configured before activation to provide a device.Type: GrantFiled: April 26, 2006Date of Patent: September 6, 2011Assignee: Civatech CorporationInventor: Fearghus O'Foghludha
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Patent number: 7988612Abstract: A brachytherapy seed comprising (a) carrier-free 103Pd isotope, (b) a substrate for the carrier-free 103Pd radioisotope, and (c) a casing for encapsulating the carrier-free 103Pd-laden substrate, is disclosed.Type: GrantFiled: July 16, 2001Date of Patent: August 2, 2011Assignee: Medi-Physics, Inc.Inventors: Michael Drobnik, Christopher Drobnik, Dave Bolenbaugh, Pamela S. Dahl, Irene Pahigianis, Scott Romanoff
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Publication number: 20110166410Abstract: A brachytherapy system for a target region (200) can include an applicator (100) having a plurality of channels (110) that are hollow where the applicator is implanted in the target region, a tracking device (175), a tracking signal generator (180) to generate a signal received by the tracking device, and a processor (550). The tracking device can have a size and shape to be advanced and retracted through at least a portion of the plurality of channels. The processor can determine a position of one or more of the plurality of channels based on a movement of the tracking device. The processor can determine the location of the plurality of channels in the images based on the position measurements from the tracking device.Type: ApplicationFiled: June 12, 2009Publication date: July 7, 2011Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Luis Felipe Gutierrez, Guy Shechter
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Patent number: 7972261Abstract: An anchor mechanism includes a sleeve to fit around a structure such as a radioactive source, a thermal ablation implant, a spacer, a strand or a radiopaque marker. The sleeve has a bore that extends an entire longitudinal length of the sleeve, and through which the structure fits, such that the structure can extend out from both longitudinal ends of the sleeve. One or more protrusion extends from an outer surface of the sleeve to engage surrounding patient tissue after implantation of the structure into a patient, to thereby reduce a tendency for the structure to migrate and rotate after implantation.Type: GrantFiled: July 20, 2006Date of Patent: July 5, 2011Assignee: Biocompatibles UK LimitedInventors: Gary A. Lamoureux, James Matons, Warren Johnston, Matthew Bouffard, Warren Rice
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Patent number: 7966746Abstract: A device and related method are provided for lyophilizing a substance within the device and storing therein the lyophilized substance. The device is penetrable by a needle for filling the device with the substance to be lyophilized, and a resulting needle hole in the device is laser resealable by transmitting thereon laser radiation from a laser source. The device defines a chamber for receiving therein the substance to be lyophilized. A needle penetrable and laser resealable portion of the device is pierceable with a needle to form a needle aperture therethrough to fill the chamber with the substance to be lyophilized through the needle, and is laser resealable to hermetically seal the needle aperture by applying laser radiation thereto.Type: GrantFiled: April 24, 2007Date of Patent: June 28, 2011Assignee: Medical Instill Technologies, LLCInventor: Daniel Py
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Publication number: 20110118532Abstract: A radiopaque brachytherapy seed for implantation into a subject includes a biocompatible component, a therapeutically active component including a non-radioactive drug, and a radiopaque marker. The biocompatible component is (a) physically associated with a therapeutically active component and (b) in contact with the radiopaque marker. The brachytherapy seed has a size and shape suitable for passing through the bore of a needle having an interior diameter of less than about 2.7 millimeters (10 gauge).Type: ApplicationFiled: May 24, 2004Publication date: May 19, 2011Inventor: Edward J. Kaplan
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Patent number: 7922646Abstract: An implantable source (40) of therapeutic radiation for brachytherapy is provided as a sealed, biocompatible capsule (410) of plastic (e.g. polyethylene or PEEK) transparent to the radiation. The capsule contains a radiation source (400) comprising particles of a radioactive isotope (e.g. Pd103, I125, Cs131) in a fluid carrier that is resistant to radiation polymerization but solidifies at elevated temperature. It also has a marker (420), and desirably has a socket (430) which accommodates attaching spacers (660) and makes possible linear strands and planar arrays of the capsules. The spacers may be functional, e.g. heat-generating or medication-releasing.Type: GrantFiled: August 20, 2004Date of Patent: April 12, 2011Assignee: International Brachytherapy, S.A.Inventors: John L. Russell, Jr., John L. Carden, Jr., Roy Coniglione, Dominique Moyaux
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Patent number: 7905822Abstract: A brachytherapy applicator for treatment of metastic lesions in a load bearing region is provided. The applicator comprises an elongate tube body having a proximal and a distal end and defining an open internal area. A fixation element located on an outer portion of the tube allows the applicator to be fixed in position in relation to a target region while delivering a dose of therapeutic radiation. The fixation element can fix the applicator to tissue and/or a stabilization element implanted within a patient. A source of radiation positioned within the elongate body, before, during, or after implantation of the applicator, provides the therapeutic radiation.Type: GrantFiled: November 22, 2004Date of Patent: March 15, 2011Assignee: Cytyc CorporationInventors: Timothy J. Patrick, James B. Stubbs
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Publication number: 20110054235Abstract: The present disclosure relates to a thermo formed tray having an upper half and a lower half. The upper half and the lower half define a closed configuration when the upper half and the lower half are substantially adjacent one another and an open configuration when the upper half and the lower half are substantially apart from one another. A predetermined area is provided in at least one of the upper half and the lower half for containing a product in the closed configuration, the product having at least one radioactive seed held in a predetermined seed configuration. At least one cutter guide is contained in the thermo formed tray.Type: ApplicationFiled: August 22, 2008Publication date: March 3, 2011Inventors: Christopher D. Drobnik, Michael W. Drobnik, James Stewart, Michael Johnson, Mark Ralph
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Publication number: 20110040161Abstract: Utilization of a contact device placed on the eye in order to detect physical and chemical parameters of the body as well as the non-invasive delivery of compounds according to these physical and chemical parameters, with signals being transmitted continuously as electromagnetic waves, radio waves, infrared and the like. One of the parameters to be detected includes non-invasive blood analysis utilizing chemical changes and chemical products that are found in the conjunctiva and in the tear film. A transensor mounted in the contact device laying on the cornea or the surface of the eye is capable of evaluating and measuring physical and chemical parameters in the eye including non-invasive blood analysis. The system utilizes eye lid motion and/or closure of the eye lid to activate a microminiature radio frequency sensitive transensor mounted in the contact device. The signal can be communicated by wires or radio telemetered to an externally placed receiver.Type: ApplicationFiled: July 8, 2010Publication date: February 17, 2011Inventor: Marcio Marc Abreu
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Patent number: RE43134Abstract: The present invention provides a denatured albumin lamina, useful for repairing lesions on solid visceral organs. The lamina comprises human serum albumin, formed into a thin, pliant sheet and denatured. The denatured lamina can be sterilized and stored until used. As well, it can be impregnated with a variety of bioagents. A method for repairing a lesion on a solid visceral organ includes applying an energy-absorbing proteinaceous material to a lesion site on the solid visceral organ lesion; irradiating the proteinaceous material with energy sufficient to fuse the energy-absorbing material at least partially to the lesion site; applying a biocompatible denatured albumin lamina onto the proteinaceous material on the lesion site; and irradiating the biocompatible albumin lamina and the proteinaceous material with energy sufficient to fuse the biocompatible albumin lamina to the proteinaceous material and/or the lesion site.Type: GrantFiled: April 8, 2005Date of Patent: January 24, 2012Assignee: Providence Health System - OregonInventors: Yasmin Wadia, Scott Alan Prahl