Abstract: A device, method, and kit for conveying a radioactive agent to a site of stenosis. The device includes a body portion to be disposed about the surface of a stent. The device comprises a radioactive agent. The device is capable of expanding, thus following the deployment movement of the stent, and is used to counter restenosis.

Abstract: A kit of parts comprises a system and instructions for use for controlling patient temperature which uses a central venous line catheter having a heat exchange element. The central venous line catheter is provided with one or more lumens for providing access to the central blood supply of the patient, and with additional lumens for communicating heat exchange fluid to the heat exchange element. Heat exchange fluid temperature is controlled through a feed back loop in which patient temperature is sensed and used to control a temperature control unit comprising a heating device and/or a cooling device in heat exchange relationship with the heat exchange fluid. A tubing set transports the heat exchange fluid between the central venous line and the temperature control unit, with a pump serving to circulate the fluid in a closed fluid circuit in the system.

Abstract: A catheter for delivering a medical agent to tissue external to a body passage through which the catheter is inserted. The catheter includes a tissue piercing member, e.g., a needle having a rectangular cross-section that is asymmetrically flexible, such that the member is substantially more flexible about a first cross-sectional axis than about a second cross-sectional axis. The tissue piercing member is thus readily deflected about one axis, away from the catheter and into the tissue, while minimizing buckling of the tissue piercing member about the other axis. The catheter can include a balloon located proximal to and on the same side as the piercing member, and a second balloon located distal to and on the opposite side as the piercing member. When inflated, the balloons cause the portion of the catheter between the balloons to flex and bend, facilitating penetration of the tissue by the tissue piercing member.

Abstract: A catheter for insertion into an artery having deposits of plaque and/or thrombus includes, at its distal end an ultrasonic transducer and a dilatation balloon surrounding the transducer such that when the balloon is positioned in the artery adjacent the deposits and inflated, energizing of the ultrasonic transducer will focus the ultrasonic energy against the deposits to cause dissolution of the thrombus into microscopic particles and cause cracking and softening of the plaque. Other embodiments include the provision of a second ultrasonic transducer as a means for viewing the treatment site, and a second balloon to cooperate with the first balloon to define a chamber between the balloons and with a lumen and a port connected to the chamber to remove any debris of larger than microscopic size which might otherwise tend to move downstream and cause further obstructions. Also described is the use of an expandable filtering device distal of the dilatation balloon for trapping such particles.

Abstract: A balloon for use in surgical procedures, such as angioplasty. The balloon is configured as a balloon catheter with an axial series of segmented chambers, each connected to a tubular core that is adapted to a transport a pressurizable fluid source. The chambers are made of an elastically expandable material that inflates in response to the introduction of a pressurized fluid source. Each chamber includes a body lumen inner wall engaging surface and a pair of generally opposed flanges. Flexibly compliant links are disposed between adjacent chambers. These links may be integral with the flanges, or may constitute a separate hinge that couples the chambers at least to the central core. As the balloon is routed through a body lumen, curvature in the lumen is mimicked by the balloon, as it is able to flexibly conform to the shape of the lumen path by preferential bending at the flexibly compliant links.

Abstract: A catheter has a lumen for a thrombectomy device and at least two balloons of different compliancies. In one embodiment, the catheter is adapted to clear dialysis grafts. One balloon is adapted to expand a stenosis at a venous junction of a dialysis graft and another balloon is adapted to expand a stenosis at an arterial junction of a dialysis graft.

Abstract: The apparatus for diverting blood from the retro hepatic inferior vena cava (IVC) and internally shunting renal and infra renal IVC blood into the right atrium during surgery on the liver, its vessels, or the retro hepatic IVC is described. It is symmetrical on its mid horizontal axis permitting similar utility whether venous access was above or below the liver. It is a hollow plastic tube with two sidewall openings, one at each end with four intervening completely encircling balloons. It is continuous with a proximal component which serves to remotely manipulate, infuse fluids and inflate the balloons in the distal component. Once introduced into the venous system by right atriotomy or infrarenally by venotomy, the distal component would be advanced and seated in the right atrium and supra renal IVC.

Abstract: The instant invention provides an apparatus, a kit and a method for treating a tumor in an extremity of a patient.

Abstract: A method and apparatus for pressurizing the right atrium or right ventricle of a beating heart during surgery to assist cardiac function. The apparatus has an intake tube for insertion in the inferior or superior vena cava, a return tube for insertion in the right atrium or right ventricle, and a pump (e.g., a peristaltic pump). In operation, blood is pumped from the vena cava into an intake port of the intake tube, from the intake tube through the pump to the return tube, and from the return tube to the right atrium or right ventricle. Optionally, a balloon mounted around the intake tube's distal end is inflated to center the intake port in the vena cava and provide a pressure bulkhead. The pump preferably pumps blood in one direction from an input port to an output port.

Abstract: Enabled or activated closure and sealing devices in the form of closure balloons, and related methods, are disclosed, which substantially preclude entry and clotting of blood at the distal end of a lumen of an indwelling catheter tube during times when flow therein is not occurring. The closure and sealing balloon is disabled or deactivated to accommodate flow, without clotting, through the lumen of the catheter tube when flow therein is resumed.

Abstract: An intraluminal device has an elongated body member having a series of independent inflatable sections along its length. At least one inflating/deflating line extends from each inflatable section to a distal end of the body member. The device may be used for positing, isolating or identifying a lumen by giving shape to a collapsed viscus. The device may also be used to visualize intraluminal structure or control pressure within a hollow viscus from within the hollow viscus.

Abstract: The present invention relates to a device for actively supporting the flow of body fluids, comprising an artificial flow guide system (10) with an operational area into which a pump (1) is embedded in such a way that it can transport blood from at least one inlet opening (3) situated in the guide system to at least one outlet opening (4) situated in the guide system; a flexible feed hose (5) connected to the flow guide system; an energy or force transmission line (6) which is guided through the interior of the flexible feed hose and which, when the device is in the operational state, transmits energy or force substantially continuously to the pump from a drive unit for the extracorporeal generation of this energy or force.

Abstract: Devices and methods are provided for temporarily inducing cardioplegic arrest in the heart of a patient and for establishing cardiopulmonary bypass in order to facilitate surgical procedures on the heart and its related blood vessels. Specifically, a catheter based system is provided for isolating the heart and coronary blood vessels of a patient from the remainder of the arterial system and for infusing a cardioplegic agent into the patient's coronary arteries to induce cardioplegic arrest in the heart. The system includes an endoaortic partitioning catheter having an expandable balloon at its distal end which is expanded within the ascending aorta to occlude the aortic lumen between the coronary ostia and the brachiocephalic artery. Means for centering the catheter tip within the ascending aorta include specially curved shaft configurations, eccentric or shaped occlusion balloons and a steerable catheter tip, which may be used separately or in combination.

Abstract: A catheter for intravascular corporeal cooling comprises an elongated tubular member having at least one lumen extending therethrough for providing cooled blood, an inflatable annular balloon positioned on the outer surface of the elongated tubular member, and a pressure reliever positioned in the external wall of the elongated tubular member and proximal to the annular inflatable balloon, wherein when the pressure of blood within a lumen reaches a predetermined value, the pressure reliever opens to permit fluid to be released from the elongated tubular member. In other embodiments of the invention the catheter may have two or more inflatable annular balloons that are separately inflatable and/or the catheter has an insulative outer annular member.

Abstract: A back-up retention member drainage catheter (10) for insertion in the bladder and urethra of a patient undergoing a radical prostatectomy surgical procedure. The drainage catheter includes an elongated tubular member (11) having a drainage lumen (14) extending longitudinally therein with an external drainage port (15, 16) disposed near the distal end (12) of the tubular member. A back-up retention member (18) and, in particular, a first balloon (20) is disposed on the elongated tubular member near the distal end and proximal the external drainage port. A primary retention member (19) and, in particular, a second retention balloon (22) is also disposed on the elongated tubular member around the first retention balloon. First and second inflation lumens (21, 23) extend longitudinally through the elongated tubular member and communicate internally with the first and second retention balloons, respectively.

Abstract: Apparatus and methods are provided for delivering oxygenated blood to a patient undergoing cardiac surgery using a perfusion catheter having a distal end carrying first and second sealing members. When the perfusion catheter is inserted through an arteriotomy site, the first and second sealing members are disposed to engage opposite surfaces of a thickness of a vessel to apply pressure against the opposite surfaces of the thickness to seal blood perfused into the vessel from leaking through the arteriotomy site. Apparatus for placing the perfusion catheter, and methods of using the apparatus also are provided.

Abstract: A catheter for use with a radioactive source within the catheter to irradiate a selected area of a blood vessel in combination with angioplasty procedures, to prevent restenosis of that area of the blood vessel. The catheter has a guidewire channel formed near its distal end to facilitate use of the catheter as a rapid exchange catheter, allowing insertion of the catheter over a guidewire also used in performance of an angioplasty procedure. The catheter also has a radiation lumen with a sealed end to retain the radioactive source within the catheter. The radiation lumen is sufficiently longer than the guidewire channel to extend into a non-sterile field, keeping the radiation source segregated from the blood, allowing the use of a non-sterile radiation source. The catheter can also be provided with a centering balloon or a set of centering wire loops to center the radioactive source radially within the blood vessel.

Abstract: A balloon catheter device designed to be especially well suited for use in providing medical treatment within a blood vessel, and a method for conducting such medical treatment are provided, wherein the balloon catheter has a central support tube or lumen, and has, near a distal end of the catheter, a plurality of inflatable balloon elements extending along the catheter in helical patterns, with the balloon elements spaced equidistantly around the central support tube. The catheter thus provides the ability to apply pressure, by way of the inflated balloon elements, to center the central support tube in the blood vessel, while at the same time preserving blood flow in the blood vessel past the catheter as well as in side branch blood vessels extending from the blood vessel under repair.