Delivering Fluid Or Material From External Surface Of Inflated Means Patents (Class 604/103.02)
  • Patent number: 10653442
    Abstract: Drug delivery systems and methods are disclosed herein. In some embodiments, a drug delivery system can be configured to deliver a drug to a patient in coordination with a physiological parameter of the patient (e.g., the patient's natural cerebrospinal fluid (CSF) pulsation or the patient's heart or respiration rate). In some embodiments, a drug delivery system can be configured to use a combination of infusion and aspiration to control delivery of a drug to a patient. Catheters, controllers, and other components for use in the above systems are also disclosed, as are various methods of using such systems.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: May 19, 2020
    Assignee: ALCYONE LIFESCIENCES, INC.
    Inventors: PJ Anand, Morgan Brophy, Deep Arjun Singh, Greg Eberl, Ayesha Arzumand, Stela Moura
  • Patent number: 10646697
    Abstract: A balloon coating method for forming a coating layer containing a water-insoluble drug on the outer surface of a balloon of a balloon catheter, wherein the balloon catheter includes an elongate shaft possessing a distal portion at which is provided the balloon which is inflatable. The balloon coating method includes: holding the shaft on a support part capable of rotating about an axis of the balloon; and moving a dispensing tube for supplying a coating liquid containing the drug relative to the balloon in an axial direction of the balloon, while rotating the balloon together with the support part, thereby to coat the outer surface of the balloon with the coating liquid.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: May 12, 2020
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Hiroshi Gotou, Yasuo Kurosaki, Eisuke Furuichi
  • Patent number: 10595874
    Abstract: A medical device may include a catheter, an expandable member, a cover, and an actuator. The catheter may include a longitudinal axis, proximal and distal ends, and a cover lumen extending from the proximal to the distal end. The expandable member may include proximal and distal ends and may be disposed on a distal section of the catheter. The cover may include a first region that may be disposed along the expandable member, and a second region that may extend along a length of the catheter beyond the proximal end of the expandable member towards the proximal end of the catheter. A first end of the cover may invert into the cover lumen. The actuator may be coupled to the first end of the cover and configured to move the first end of the cover towards the proximal end of the catheter along the longitudinal axis of the catheter.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: March 24, 2020
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Michael Broyles, Bret J Kilgrow
  • Patent number: 10588737
    Abstract: Improvements for use with tissue expanders are provided. A first aspect includes a tissue expander device provided with a colorant inside a shell before the shell is inflated with fluid, wherein the colorant mixes with fluid upon injection of fluid into the shell. A second aspect includes a tissue expander device provided with a tread on an exterior surface of the shell. A third aspect includes a system having: a computing device with a visual display screen; a detector connected to the computing device that is configured to detect a port of a tissue expander that is implanted under skin of a patient; and software running on the computing device that receives signals from the detector and causes the visual display screen to show a visual representation of a location of the detected port of the tissue expander.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: March 17, 2020
    Inventor: William T. McClellan
  • Patent number: 10575864
    Abstract: Devices and methods for securing a cover of a retrieval device while the retrieval device is resheathed to a more proximal position within a delivery sheath are disclosed herein. A retrieval device may include, for example, a securing element configured to grip the cover when the retrieval device is pulled proximally, to thereby secure the cover. A method of positioning the retrieval device may include, for example: (a) advancing the retrieval device distally through a delivery sheath to a partially deployed state while the securing element is in a first state, and (b) retracting the clot retrieval proximally from the partially deployed state while the securing element is in a second state that grips the cover to secure the cover.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: March 3, 2020
    Assignee: COVIDIEN LP
    Inventors: Erik Skillrud, Daniel Deen, Evan Epstein
  • Patent number: 10575893
    Abstract: Devices and methods for treating one or more pulmonary diseases while avoiding or minimizing injury to the esophagus and branches of the vagus nerve that run along the outside of the esophagus. The device includes at least one energy delivery element disposed on an elongate member and a means for protecting the esophagus and surrounding tissues, such as esophageal branches of the vagus nerve, during treatment. The energy delivery element is positionable to target at least one nerve in or around the tracheal wall when the elongate member is positioned in the trachea. Energy from the energy delivery element is delivered to the at least one nerve to treat pulmonary symptoms, conditions, and/or diseases, such as asthma, COPD, obstructive lung diseases, or other pulmonary diseases, while the protection means protects the esophagus and surrounding tissues from permanent damage.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: March 3, 2020
    Assignee: Nuvaira, Inc.
    Inventor: Martin L. Mayse
  • Patent number: 10517623
    Abstract: Briefly, in accordance with one embodiment, a tool for use with an endoscopic procedure comprises a thermoplastic polyurethane expandable vessel.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: December 31, 2019
    Assignee: Conmed Corporation
    Inventors: Andrew Joseph Dusbabek, Scott Arvin Olson, Christen Andrew Springs, Isaac Raijman
  • Patent number: 10500378
    Abstract: A balloon catheter adapted for use with a guidewire includes an elongated, tubular shaft extending in a longitudinal direction, said shaft having a proximal end and a distal end. An inflatable balloon is supported along the distal end of the shaft, the balloon when inflated including first and second spaced ends and a working surface between the ends. An insert located within the interior compartment of the balloon includes at least a radiopaque portion separate from the shaft. Related methods are also disclosed.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: December 10, 2019
    Assignee: CLEARSTREAM TECHNOLOGIES LIMITED
    Inventors: Pat Byrne, Angela Susan Crall, Angela Kay Jensen, Andrew Schaffer, Sean Wall
  • Patent number: 10427184
    Abstract: Disclosed herein is a balloon coating method for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter, the balloon catheter including the balloon which is inflatable and provided on a distal portion of an elongate shaft. The balloon coating method includes: accommodating the shaft in a groove portion formed in a support base to extend rectilinearly, and closing at least part of the groove portion with a lid portion, thereby to support the shaft such that the shaft can be rotated within the groove portion; and moving a dispensing tube for supplying a coating liquid containing the drug relative to the balloon in an axial direction of the balloon, while rotating the balloon about an axis of the balloon, thereby to coat the outer surface of the balloon with the coating liquid.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: October 1, 2019
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Hiroshi Gotou, Yasuo Kurosaki, Eisuke Furuichi
  • Patent number: 10398579
    Abstract: A catheter system including a delivery sheath and a wire management device. The wire management device is slidably disposed within a lumen of the sheath, and includes a shaft and at least two vane assemblies. The vane assemblies each project from an exterior surface of the shaft and are circumferentially spaced from one another. Further, the vane assemblies are collapsible to a collapsed stated when disposed within the lumen, and are configured to self-expand from the collapsed state toward a normal, expanded state when released from the lumen. The catheter assembly generates a plurality of compartments that are separated from one another by the vane assemblies and along which individual guidewires can be tracked. The compartments maintain the guidewires separate from one to prevent possible twisting. An advancing endograft delivery device tracked over the guidewires collapses the vane assemblies, coalescing the compartments into a single compartment during endograft deployment.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: September 3, 2019
    Assignee: Regents of the University of Minnesota
    Inventor: Rumi Faizer
  • Patent number: 10368972
    Abstract: A blood clot filter includes a number of locator members and anchor members, each of the members tipped with a retainer encompassed within bio-resorbable cover material. Upon delivery into a blood vessel, the locator and anchor members position the filter near the vessel centerline. After a period of time, the bio-resorbable cover material resorbs, allowing the retainer on the members to penetrate and attach to the vessel wall. A method of implanting the filter includes delivering the filter into a blood vessel and allowing the bio-resorbable cover material to resorb so retainers on the members can engage the vessel walls.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: August 6, 2019
    Assignee: C.R. BARD, INC.
    Inventors: Alexander Germanovich Kashkarov, Andrzej J. Chanduszko
  • Patent number: 10258487
    Abstract: Expandable elements having drug-delivery features and associated systems and methods are disclosed herein. In one embodiment, a drug-eluting stent includes a radially expandable cylindrical frame having a plurality of struts. The frame is transformable between a low-profile delivery state and an expanded deployed state. A plurality of drug-delivery features are carried by one of the struts and configured to deliver a drug to a treatment site within the patient or piercing through the tissue wall to break the constricting of the vessel wall inwardly. When the frame is in the expanded state within a body lumen of the patient, the drug-delivery features extend radially outwardly away from the strut and are configured to engage and, in some arrangements, pass through a wall of the body lumen.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: April 16, 2019
    Assignee: REFLOW MEDICAL, INC.
    Inventors: John Fulkerson, Isa Rizk, Jihad Ali Mustapha, Teodoro S. Jimenez, Jr.
  • Patent number: 10172729
    Abstract: Expandable elements having drug-delivery features and associated systems and methods are disclosed herein. In one embodiment, a drug-eluting stent includes a radially expandable cylindrical frame having a plurality of struts. The frame is transformable between a low-profile delivery state and an expanded deployed state. A plurality of drug-delivery features are carried by one of the struts and configured to deliver a drug to a treatment site within the patient or piercing through the tissue wall to break the constricting of the vessel wall inwardly. When the frame is in the expanded state within a body lumen of the patient, the drug-delivery features extend radially outwardly away from the strut and are configured to engage and, in some arrangements, pass through a wall of the body lumen.
    Type: Grant
    Filed: October 12, 2016
    Date of Patent: January 8, 2019
    Assignee: REFLOW MEDICAL, INC.
    Inventors: John Fulkerson, Isa Rizk, Jihad Ali Mustapha, Teodoro S. Jimenez, Jr.
  • Patent number: 10118025
    Abstract: A balloon catheter which can rather smoothly move inside living body organs, and can improve trackability and pushability. The balloon catheter has an inner shaft that includes a guidewire lumen into which a guidewire can be inserted, an outer shaft that forms a fluid lumen for introducing a fluid on an outer periphery of the inner shaft, a membranous material that causes a space portion into which the fluid can flow to communicate with the fluid lumen, and that partitions the space portion on the outer periphery of the distal portion side of the inner shaft, and an inflatable and deflatable balloon in which a lumen into which the fluid can flow is formed on an outer periphery of the membranous material.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: November 6, 2018
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventor: Yuta Doi
  • Patent number: 10105519
    Abstract: An apparatus for performing a medical procedure includes a balloon comprising an inflatable body. A first releasable or frangible connection is provided to maintain the body at a first diameter up to a first inflation pressure, and to release, such as by disconnecting, and thus allow the body to assume a second diameter, such as at a second inflation pressure greater than the first inflation pressure or upon a manual release of the connection by a clinician. Multiple releasable or frangible connections may be provided, including between portions (folds) of the inflatable body of the balloon. This disclosure also pertains to a non-compliant or semi-compliant balloon having a first inflation diameter corresponding to a first range of inflation pressures and a second inflation diameter corresponding to a second inflation pressure greater than the first range of inflation pressures.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: October 23, 2018
    Assignee: C.R. BARD, INC.
    Inventor: Andrzej J. Chanduszko
  • Patent number: 10092508
    Abstract: Implantable devices including a biocompatible matrix configured for long term location in adipose tissue and a biologically active agent that can be carried by the matrix and delivered to the adipose tissue following implant therein. The biologically active agent can include a modulator or a precursor thereof that can directly or indirectly modify the gene expression of adipose cells, e.g., adipocytes, and thereby modify the presence or quantity of one or more expression products of the adipose tissue that may act locally on distant from the implant site in an endocrine fashion. Modulators can include small molecules (e.g., resveratrol), polynucleotides (e.g., RNAi), or polypeptides (e.g., antibodies or functional fragments thereof).
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: October 9, 2018
    Assignee: University of South Carolina
    Inventors: Robert Gower, Michael Hendley
  • Patent number: 10052461
    Abstract: This disclosure relates to medical devices and related methods. In some embodiments, the methods include applying a material to the balloon and then removing the material from one or more regions of the balloon.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: August 21, 2018
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Thomas J. Holman, James Lee Shippy, III, Afsar Ali
  • Patent number: 10039655
    Abstract: A stent with varying porosity is described. The stent can be comprised of multiple stents attached together. A braided stent may have selected regions of increased thickness. The stent may be comprised of wires that are welded together at their ends in order to minimize vessel trauma. The stent may comprise a helically wound radiopaque wire wound through the stent.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: August 7, 2018
    Assignee: MicroVention, Inc.
    Inventors: Ponaka Pung, Helen Nguyen, Tai D. Tieu
  • Patent number: 10016536
    Abstract: Various aspects of the present invention provide compositions and implantable devices including a water-insoluble therapeutic agent solubilized in a matrix of a gallate-containing compound. Other aspects provide methods of manufacturing and using such compositions and devices.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: July 10, 2018
    Assignee: COOK MEDICAL TECHNOLOGIES LLC
    Inventors: John Jackson, Lindsay Stuart Machan, Kevin Letchford
  • Patent number: 9974931
    Abstract: This present invention concerns a new combination of balloon catheters and formulations containing active substances that adhere to the surface of the balloon membrane. Furthermore the present invention concerns coating processes for the manufacture of these balloon catheters as well as their use in the treatment and prophylaxis of vascular diseases.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: May 22, 2018
    Assignee: Invatec Technology Center GMBH
    Inventors: Bruno Scheller, Ulrich Speck
  • Patent number: 9895248
    Abstract: Devices and methods for treating obesity are provided. More particularly, intragastric devices and methods of fabricating, deploying, inflating, locating, tracking, monitoring, deflating, and retrieving the same are provided.
    Type: Grant
    Filed: October 7, 2015
    Date of Patent: February 20, 2018
    Assignee: Obalon Therapeutics, Inc.
    Inventors: Mark C. Brister, Neil R. Drake, Sheldon Nelson
  • Patent number: 9872685
    Abstract: The present disclosure is directed a method of facilitating treatment via a vascular wall defining a vascular lumen containing an occlusion therein. The method may include providing a first intravascular device having a distal portion and at least one aperture and positioning the distal portion of the first intravascular device in the vascular wall. The method may further include providing a reentry device having a body and a distal tip, the distal tip having a natural state and a compressed state and inserting the distal tip, in the compressed state, in the distal portion of the first intravascular device. The method may further include advancing the distal tip, in the natural state, through the at least one aperture of the first intravascular device.
    Type: Grant
    Filed: May 14, 2012
    Date of Patent: January 23, 2018
    Assignee: BridgePoint Medical, Inc.
    Inventors: Chad John Kugler, Matthew Jonathan Olson, Ross Arlen Olson, David B. Robinson, Peter Alan Jacobs
  • Patent number: 9861726
    Abstract: A method for coupling a body conduit to tissue is provided. The method includes engaging an implant about an outer surface of a catheter. The implant receives a bioactive agent having tissue growth properties. The method involves inserting the catheter through the body conduit and into a tissue opening across a resected area, positioning the implant in the resected area, inflating a balloon to anchor the catheter within the tissue opening such that the implant bridges the body conduit and the tissue opening across the resected area, and maintaining the catheter and the implant in vivo to enable the bioactive agent to secure the implant in the resected area to permanently bridge the body conduit and the tissue opening.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: January 9, 2018
    Assignee: COVIDIEN LP
    Inventors: Joe D. Sartor, Anthony B. Ross, Stephen Wohlert
  • Patent number: 9808650
    Abstract: A method for brachytherapy in a lumpectomy cavity of a breast including, positioning a distal end of a brachytherapy device within the cavity, expanding an expandable surface portion located between proximal and distal ends of the device within the cavity, the source lumen tubes defining a curved configuration within the cavity; and positioning a source of radiation sequentially within one or more source lumens of the source lumen tubes according to a brachytherapy treatment plan. The device includes an inner tube, and a plurality of source lumen tubes located around the inner tube and including distal ends secured together with the inner tube at the distal end disposed within the body cavity, the source lumen tubes comprising proximal portions sufficiently long to extend outside the breast.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: November 7, 2017
    Assignee: Theragenics Corporation
    Inventors: Jack C. White, David Wesley Stephens, Amit Prakash Govil, Joshua J. Bergman, Nathan Christopher Griffith, Kyle Kevin Millage
  • Patent number: 9801831
    Abstract: Present invention relates to a device for controlled release of a bioactive agent. The device comprises a thin film located on the surface of the device, wherein said thin film comprises a bioactive agent-containing layer comprising a polymeric matrix and at least one bioactive agent.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: October 31, 2017
    Assignee: Nanyang Technological University
    Inventors: Terry W. J. Steele, Say Chye Joachim Loo, Subramanian Venkatraman, Yin Chiang Freddy Boey
  • Patent number: 9730818
    Abstract: An endoluminal device can be configured for precise positioning during deployment within a vessel. The endoluminal device can be a tack, stent, vascular implant or other type of implant. The endoluminal device can have circumferential member with an undulating configuration having multiple inward and outward apexes and struts extending therebetween. Two of the struts can be used to establish a foot for the precise positioning of the device during deployment. A method of placing the endoluminal device can include withdrawing an outer sheath such that a portion of the endoluminal device is expanded prior to the rest of the endoluminal device.
    Type: Grant
    Filed: January 24, 2013
    Date of Patent: August 15, 2017
    Assignee: Intact Vascular, Inc.
    Inventors: Robert M. Giasolli, Peter Schneider
  • Patent number: 9717889
    Abstract: The present disclosure is directed to a device. The device may include a distal shaft defining a central lumen and an orienting element comprising at least one inflatable member. Wherein a first portion of the orienting element extending from the shaft in a first direction and a second portion of the orienting element extending from the shaft in a second direction. Further, wherein the second direction is substantially opposite the first direction.
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: August 1, 2017
    Assignee: BridgePoint Medical, Inc.
    Inventors: Chad J. Kugler, Matthew J. Olson, Ross A. Olson, David B. Robinson
  • Patent number: 9669134
    Abstract: Provided herein are methods for treating an individual having (suffering from) an acute myocardial infarction and drug eluting stents useful for treating such individuals. These methods include treating an individual by introducing, such as by surgically inserting, at a site of an acute coronary artery occlusion upstream of the site of acute myocardial infarction, a drug eluting stent (DES) that is capable of eluting from 25 pg to 950 pg of IGF-1 directly into the coronary circulation. The treatment is specifically directed to stimulation of repair or survival of damaged cardiac muscle or left ventricular remodeling.
    Type: Grant
    Filed: November 27, 2009
    Date of Patent: June 6, 2017
    Assignee: UNIVERSITY COLLEGE CORK, NATIONAL UNIVERSITY OF IRELAND, CORK
    Inventor: Noel Caplice
  • Patent number: 9669192
    Abstract: The present invention provides insertable medical devices having elastic surfaces associated with bioactive agent-containing microparticulates and a coating material. Upon expansion of the elastic surfaces the microparticulates can be released to a subject.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: June 6, 2017
    Assignee: Surmodics, Inc.
    Inventors: James Howard Arps, Andrew G. Bach
  • Patent number: 9662677
    Abstract: Method of coating an expandable member, e.g. balloon, is provided, the method comprising providing an expandable member having an outer surface. The method includes a plasma treatment with a supply of gas performed on at least a portion of the outer surface of the expandable member. A therapeutic agent is applied on at least the plasma treated portion of the outer surface of the expandable member after the plasma treatment is performed. The plasma treatment can reduce the adhesion of therapeutic agent to the surface of the expandable member. A medical device made by the disclosed method is also provided.
    Type: Grant
    Filed: September 15, 2010
    Date of Patent: May 30, 2017
    Assignee: ABBOTT LABORATORIES
    Inventors: Anthony S. Andreacchi, Stephen D. Pacetti, John Stankus, Victoria M. Gong, Michael J. Leonard, Binh Nguyen
  • Patent number: 9649476
    Abstract: For selective treatment of diseased tissue sections or organ parts, the surface of medical devices entering into contact with areas thereof under pressure is coated with lipophilic substantially water-insoluble medicaments binding to various tissue components with good adherence thereto, said medicaments having an effect thereupon a short time after entering into contact therewith without exerting a harmful influence upon adjacent healthy tissue.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: May 16, 2017
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Ulrich Speck, Bruno Scheller
  • Patent number: 9642663
    Abstract: A system comprises an inflatable bone tamp including a plurality of linearly aligned expandable bodies. The system further comprises an elongated tubular shaft extending through the plurality of linearly aligned expandable bodies. The elongated tubular shaft includes a shaft wall and an interior partition structure. The system further comprises a plurality of channels extending through the shaft, each of the channels formed by a segment of the shaft wall and the interior partition structure and each of the channels in communication with the respective one of the plurality of expandable bodies via openings in the shaft. Each of the expandable bodies is independently inflatable.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: May 9, 2017
    Assignee: KYPHON SÀRL
    Inventors: Craig E. Lauchner, Michael A. Smith
  • Patent number: 9610427
    Abstract: A process for making a folded composition-eluting balloon catheter includes coating one or both surfaces of a one or more foldable wings with a hydrophilic coating, applying a composition as a coating on the coated surface and providing the composition within a fold of the one or more foldable wings, and folding the one or more foldable wings to seal the composition by the one or more foldable wings to prevent/reduce its release until after inflation of the balloon. Another process for making a folded composition-eluting balloon catheter includes coating one or both surfaces of the one or more foldable wings with a hydrophilic coating-composition mixture and providing the composition by the one or more foldable wings, and folding the one or more foldable wings to seal the composition between the fold of the one or more foldable wings to prevent/reduce its release until after an inflation of the balloon.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: April 4, 2017
    Assignee: WELLINQ MEDICAL B.V.
    Inventor: Ronald Adrianus Maria Horvers
  • Patent number: 9603619
    Abstract: A cutting balloon catheter and method of making and using the same. The cutting balloon catheter may include a catheter shaft having a balloon coupled thereto. One or more cutting members or blades may be coupled to the balloon. The cutting members may configured to be more flexible.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: March 28, 2017
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Steven W. Bence, Alexander J. Asconeguy
  • Patent number: 9597210
    Abstract: Apparatuses and methods for coating and/or loading a medical device with a therapeutic agent prior to or during the placement of the medical device within the patient's body. In one variation, the medical device is coated and/or loaded with a therapeutic agent while the device is positioned in a delivery apparatus. In another variation, the delivery apparatus comprises a reservoir for retaining a therapeutic agent. The user may release the therapeutic agent from the reservoir prior to or during the placement of the device to coat and/or load the device with the therapeutic agent.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: March 21, 2017
    Assignee: C. R. Bard, Inc.
    Inventors: John D. McDermott, Alexander W. Tessmer, David G. Spilka
  • Patent number: 9539381
    Abstract: Materials and methods for reducing or preventing bleeding and associated side effects during and after percutaneous medical procedures.
    Type: Grant
    Filed: December 12, 2012
    Date of Patent: January 10, 2017
    Assignee: Humparkull, LLC
    Inventor: Mitchell R. Humphreys
  • Patent number: 9486611
    Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a guide extension catheter. The guide extension catheter may include an elongate tubular member having a proximal region, a distal region, and a slot formed in the tubular member between the proximal region and the distal region. The proximal region of the tubular member may be configured to shift between a first configuration and a collapsed configuration. The guide extension catheter may also include an elongate shaft for shifting the proximal region between the first configuration and the collapsed configuration.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: November 8, 2016
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Eric M. Petersen, Steven R. Larsen, Wayne Falk, Joel M. Wasdyke, Huisun Wang
  • Patent number: 9468513
    Abstract: A blood clot filter includes a number of locator members and anchor members, each of the members tipped with a retainer encompassed within bio-resorbable cover material. Upon delivery into a blood vessel, the locator and anchor members position the filter near the vessel centerline. After a period of time, the bio-resorbable cover material resorbs, allowing the retainer on the members to penetrate and attach to the vessel wall. A method of implanting the filter includes delivering the filter into a blood vessel and allowing the bio-resorbable cover material to resorb so retainers on the members can engage the vessel walls.
    Type: Grant
    Filed: June 2, 2014
    Date of Patent: October 18, 2016
    Assignee: C.R. BARD, INC.
    Inventors: Alexander Germanovich Kashkarov, Andrzej J. Chanduszko
  • Patent number: 9302081
    Abstract: An assist device (10) for sclerosing treatment of varicose veins, aimed at being partially inserted into a blood vessel (20), including a tubular element (11), which has at least three ways (13, 14, 15), at least two of which (13, 14) are connected each one to at least one related inflatable balloon element (12, 12?, 16) by at least one through hole (30, 31), and at least one remaining way (15) of said three ways (13, 14, 15) has likewise at least one hole (32) for the passage of a sclerosing substance (17), aimed at reaching a wall (18) of said blood vessel (20), in which at least one (16) of said at least two balloon elements (12, 12?, 16) has an elongated shape extending toward at least another balloon element (12, 12?) and a variable volume comprised in the range of 30% to 99% of the space inside said blood vessel, independently from the initial dimensions of the vessel (20), interposed between the external surfaces of the outermost of said at least two balloon elements (12, 12?, 16).
    Type: Grant
    Filed: December 4, 2007
    Date of Patent: April 5, 2016
    Assignee: I-VASC S.R.L.
    Inventor: Mario Salerno
  • Patent number: 9248256
    Abstract: A medical treatment device enables an injection needle to accurately puncture brain tissue at a prescribed position and a drug solution to be injected into brain tissue, while avoiding damage to the brain tissue as the injection needle is handled. The use of the medical treatment device involves inflating a first balloon located on the outside of a catheter, directing a distal portion of a puncture needle, which is located inside the catheter, to outside the catheter through an opening in the catheter, after which the first balloon is deflated and a second balloon is inflated, and moving the catheter towards the brain tissue located on the opening side so that the injection needle projecting from the opening punctures the brain region.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: February 2, 2016
    Assignee: TERUMO KABUSHIKI KAISHA
    Inventors: Toshiaki Takagi, Yousuke Ootani, Yusuke Sekine, Ryuusuke Takashige
  • Patent number: 9242073
    Abstract: An apparatus for delivery through a vessel including an extensor segment and first and second anchor segments positioned on either side of the extensor segment, wherein each segment has associated with it an individually-addressable electro-active polymer.
    Type: Grant
    Filed: August 18, 2006
    Date of Patent: January 26, 2016
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Derek Sutermeister, Jay Rassat, Dan Wefel
  • Patent number: 9220875
    Abstract: This present invention concerns a new combination of balloon catheters and formulations containing active substances that adhere to the surface of the balloon membrane. Furthermore the present invention concerns coating processes for the manufacture of these balloon catheters as well as their use in the treatment and prophylaxis of vascular diseases.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: December 29, 2015
    Assignee: Invatec Technology Center GmbH
    Inventors: Bruno Scheller, Ulrich Speck
  • Patent number: 9180273
    Abstract: Methods and apparatus for delivering a substance to a target tissue are provided which may include any number of features. One feature is storing a substance or drug in a reservoir or reservoirs over an expandable member. The expandable member can be a balloon catheter, for example. The reservoir(s) can be disposed in a Transforming Reservoirs Matrix layer disposed over the expandable member. Another feature is a mechanical activator or a plurality of mechanical activators positioned near the reservoir(s).
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: November 10, 2015
    Inventor: Michal Konstantino
  • Patent number: 9033919
    Abstract: The invention relates to a coated medical device for rapid delivery of a therapeutic agent to a tissue in seconds to minutes. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, at least one of an oil, a fatty acid, and a lipid, and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, a part that has an affinity to the therapeutic agent by charge, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is at least one of a surfactant and a chemical compound. In further embodiments, the chemical compound is water-soluble.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: May 19, 2015
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • Patent number: 9028444
    Abstract: The instant invention provides for a pivoting ring that can be used as a seal for an inflatable member. The pivoting ring seal offers a mechanical action which acts to tighten with increasing inflation and/or expansion of an inflatable member. As the inflatable member increases in pressure and/or size, one side of the ring is lifted and pivots around a fulcrum in the middle of the ring seal causing the opposite side of the ring seal to decrease in diameter. The pivot ring causes the opposite part of the seal to tighten about an inner member allowing for a higher-pressure seal. In addition to a higher pressure seal, the working length of the inflatable member can be adjusted by moving the ring along the length of the inflatable member.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: May 12, 2015
    Assignee: W. L. Gore & Associates, Inc.
    Inventors: Carey V. Campbell, Nathan L. Friedman, Benjamin M. Trapp
  • Patent number: 9023371
    Abstract: Medical device are provided for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is water-soluble. In further embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has a molecular weight of from 80 to 750 or has more than four hydroxyl groups.
    Type: Grant
    Filed: March 18, 2013
    Date of Patent: May 5, 2015
    Assignee: Lutonix, Inc.
    Inventor: Lixiao Wang
  • Publication number: 20150112256
    Abstract: A balloon catheter includes an elongated, tubular shaft extending in a longitudinal direction, said shaft having a proximal end and a distal end. An inflatable balloon is supported along the distal end of the shaft, the balloon when inflated including first and second spaced conical end sections and a working surface between the conical sections. The balloon further includes at least one radiopaque marking identifying the transition from the conical end section to the working surface. Related aspects are also disclosed.
    Type: Application
    Filed: March 8, 2013
    Publication date: April 23, 2015
    Inventors: Pat Byrne, Angela Susan Crall, Robert Righi, Allan Ronan, Paul Merton Wales, Sean Wall
  • Publication number: 20150112257
    Abstract: A balloon catheter adapted for use with a guidewire includes an elongated, tubular shaft extending in a longitudinal direction, said shaft having a proximal end and a distal end. An inflatable balloon is supported along the distal end of the shaft, the balloon when inflated including first and second spaced ends and a working surface between the ends. An insert located within the interior compartment of the balloon includes at least a radiopaque portion separate from the shaft. Related methods are also disclosed.
    Type: Application
    Filed: March 8, 2013
    Publication date: April 23, 2015
    Inventors: Pat Byrne, Angela Susan Crall, Angela Kay Jensen, Andrew Schaffer, Sean Wall
  • Patent number: 9011411
    Abstract: Apparatus and methods for treatment of an internal cavity are provided. The internal cavity is coated with a treatment solution. The treatment solution can include a solidifiable matrix with or without a drug or combination of drugs incorporated therein, or a drug solution without a solidifiable matrix. The treatment solution is coated onto at least a portion of the internal cavity, and acts as a slow-release drug delivery system.
    Type: Grant
    Filed: December 23, 2012
    Date of Patent: April 21, 2015
    Assignee: Theracoat Ltd.
    Inventors: Asher Holzer, Dorit Daniel, Eran Hirszowicz
  • Patent number: 9011896
    Abstract: The present invention is related to scoring or cutting balloon catheters carrying at least on a portion of their surface at least one oxidation-insensitive drug or oxidation-insensitive polymer-free drug preparation and at least one lipophilic antioxidant at a ratio of 3-100% by weight of the at least one lipophilic antioxidant in relation to 100% by weight of the drug, wherein the at least one oxidation-insensitive drug is selected of taxanes, thalidomide, statins, corticoids and lipophilic derivatives of corticoids, and the at least one lipophilic antioxidant is selected of nordihydroguaiaretic acid, resveratrol and propyl gallate.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: April 21, 2015
    Assignee: AngioScore, Inc.
    Inventors: Ulrich Speck, Madeleine Caroline Berg