Abstract: A balloon catheter for use with an endoscope may have a flexible shaft extending between a proximal and distal end, with a hub affixed to the proximal end, and a balloon that has one or more visual markers. An additional optional feature is that the markers(s) may be color-coded.

Abstract: A catheter assembly comprises a catheter shaft having a first region and a second region. The first region is less radiopaque than the second region. The first region is constructed of a shaft material and the second region is constructed from the shaft material in combination with at least one radiopaque material. At least a portion of the shaft material of the second region defines at least one grooved region. The at least one radiopaque material is positioned at least partially within the at least one grooved region.

Abstract: A catheter includes a distal end, a proximal end, an outer tube extending from the distal end to the proximal end, and an inner tube extending through the outer tube. The distal end including a corrugated section attached to an end of the inner tube and an asymmetric balloon attached to the outer tube and configured to deflect the distal end of the catheter.

Abstract: A balloon catheter, and a method of making the balloon catheter, having at least one visible mark which is visible from an outer surface of the balloon. The balloon catheter is configured for use as a dilatation catheter or stent delivery system, and the visible mark facilitates assembly of the balloon catheter or stent delivery system. In a presently preferred embodiment, the visible mark is an ink coating mark, a titanium oxide mark, or a scorch mark.

Abstract: A therapeutic agent delivery system includes an irrigating shaped form, such as a non-perforated irrigating shaped form, fluidly coupled with a container storing a first agent. The irrigating shaped form is sized and dimensioned for positioning within a patient's body. A second agent is disposed at the irrigating shaped form. The second agent can either be supplied separately to the irrigating shaped form, pre-exist within the irrigating shaped form, exist as a coating or other residual element on the irrigating shaped form, or the like. The irrigating shaped form is expanded to maximum predetermined diameter and pressed against a targeted location within a patient's body. In a corresponding method, upon delivery of a first agent from the first agent container through the irrigating shaped form, the first agent reacts with the second agent forming a therapeutic agent, which can be pressurized. The therapeutic agent emits from a portion of the irrigating shaped form at the targeted location.

Abstract: A medical device has a cuff adapted to be positioned in the trachea of a subject with a patient tube, and a first tube having a distal end coupled to the cuff and a proximal end communicable with the surroundings. More effective and simpler sample taking and/or dosing of medicament is achieved by a second tube that is coupled with a distal end to the cuff and communicable with the surroundings via a proximal end, together with a pumping device that is connected to the proximal end of the first tube and to the proximal end of the second tube in order to circulate a fluid through the cuff. The cuff has a membrane that is permeable to a specific substance, the membrane being disposed to allow transfer of the specific substance between the interior and the exterior of the cuff.

Abstract: Desired portions of a balloon may be marked by varying the texture of the surface. Marking the balloon facilitates positioning of the balloon on a catheter and facilitates positioning a medical device on the balloon.

Abstract: A catheter having a radiopaque marker and a method of forming the radiopaque marker on the catheter component. One embodiment of the invention is directed to a method of making a radiopaque marker on a catheter component comprising depositing a first layer of radiopaque material onto at least a section of the catheter component, which in a presently preferred embodiment is deposited by thin film deposition, and electroplating a second layer of radiopaque material onto an outer surface of the first layer of radiopaque material. In one embodiment of the invention, a catheter component has a radiopaque marker comprising a first layer of radiopaque material, and a second layer of radiopaque material on the first layer having a thickness greater than the thickness of the first layer. In another embodiment of the invention, a first layer of radiopaque material comprises a blend of polymeric material and radiopaque material and a second layer of radiopaque material is electroplated onto the blended first layer.

Abstract: Desired portions of a balloon may be marked by varying the texture of the surface. Marking the balloon facilitates positioning of the balloon on a catheter and facilitates positioning a medical device on the balloon.

Abstract: Methods of treating the prostate include administering a thermal ablation therapy and inhibiting the obstruction or closure of the prostatic urethral opening by forming a biodegradable stent in situ in the subject such that the stent attaches to the walls of the prostatic urethra. A related method of treating BPH includes thermally treating or ablating localized tissue in the prostate with a treatment catheter and inserting flowable stent material via the treatment catheter into the prostate (either before, during, or after the thermal treatment), forming the flowable stent material so that it defines a stent that remains in position after removal of the treatment catheter to inhibit the closure of the urinary passage. Associated stents and catheters are included.

Abstract: The present invention is directed to a balloon for an intracorporeal catheter having at least a portion of its walls having radiopaque properties. The balloon is formed of a polymeric material, which has a single wall thickness of at about 0.001 inches to about 0.0125 inches while deflated. The radiopaque portion of the balloon has a thickness of about 0.00025 inches to about 0.012 inches, specifically about 0.002 inches to about 0.003 inches. The balloon is constructed of layers. The radiopaque material may be embedded within the film or deposited on the film to create radiopaque properties.

Abstract: Methods and apparatuses for positioning a radiation source in vivo relative to radio-opaque markers on a catheter that delineate a therapeutic treatment length so that a therapeutic dose of radiation is delivered along the therapeutic treatment length.

Abstract: The multilumen catheter (2) is provided at one end with a needle system (9, 9′) formed by two or more single-lumen needles which are provided with respective discharge openings (110, 111) and which, via their longitudinal lumina (10, 11), are connected to corresponding lumina (3, 4) of the catheter for separate release of a tracer fluid for external image diagnostics systems and therapeutic fluids, for example DNA plasmids. The needles may be both straight or both helical or one of these needles may be straight and the other needle may be helical.

Abstract: A catheter assembly comprising a shaft and at least one flexible radiopaque marker affixed with the shaft. Flexibility of radiopaque marker is achieved by using a segmented band of radiopaque material or a coiled band formed by winding a wire or hollow tube filled with radiopaque material. The flexible radiopaque marker may be affixed with the shaft by an adhesive, by swaging, by crimping, by soldering, or by spring-action tension fit against the shaft.

Abstract: The present invention relates to a device and method for endoluminal delivery of fluid, such as therapeutic fluid, into the vessel wall that minimizes loss of the fluid. In one embodiment, a catheter for delivering fluid or therapeutic into a vessel wall is provided, wherein the catheter has at least one injector for delivering fluid and a sealing mechanism for preventing or minimizing passage of fluid through an unengaged injector.

Abstract: A guide catheter has properties that promote enhanced visibility of the guide catheter using fluoroscopic or ultrasonic imaging techniques. The tip of the guide catheter may incorporate a material that is both fluoro and echo visible. The first material also may be provided in various amounts along the length of the guide catheter. In addition, the guide catheter may incorporate a reinforcing braid that includes one or more strands of a second material that is radio-opaque. As a result, the result guide catheter achieves improved radio-opacity and echogenicity.

Abstract: Apparatus for enhancing pushability and minimizing kinking of a balloon catheter is provided, wherein a catheter comprises inner and outer tubes, and a balloon that is proximally affixed to the outer tube and distally affixed to the inner tube. The outer tube extends distal to the proximal affixation point and at least partially into the balloon segment to provide additional stiffness and pushability. The outer tube may taper and connect to the inner tube or to radiopaque markers disposed thereon. The outer tube further may be selectively reinforced, as by using multipart construction or using different tube textures, to selectively provide added stiffness in areas susceptible to kinking.

Abstract: A thrombolysis catheter system having a fixed length infusion zone is disclosed. The invention contemplates apparatus, method and kit aspects. The apparatus, which has the capability to track a guidewire, uses a multilumen catheter to deliver radially thrombolytic agent to an infusion zone defined by one or more balloon means. In one aspect, with an occluder means, a primary lumen of the catheter is used both for catheter placement and delivery of fluid. The method discloses utilization of radiopaque indicia to place the catheter in proximity to the occlusion or diseased tissue to be treated. The kit includes a catheter of the invention in conjunction with a steerable guidewire and a tip occluder wire, either or both of the tip occluder wire and the guidewire having an enlargement on their distal tip which cooperates with a reduced diameter portion of the catheter lumen.

Abstract: A catheter (10, 10′, 10″, 10′″), in particular for insertion into blood vessels of the human body, having at least one sensor (32) which is arranged at the distal end (12) of the catheter (10, 10′, 10″, 10′″) and which is adapted to pick up a spacing signal which is dependent on the spacing of the sensor (32) with respect to the vessel wall, and control means (36, 36′, 36″) which are connected to the sensor for taking over the spacing signal.

Abstract: A distal tip for a catheter which is defined by a matrix and at least one stripe. The matrix is defined by at least one matrix material, and the at least one stripe is defined by at one stripe material. The predetermined hardness of the at least one stripe material has a greater durometer value than the predetermined hardness of the at least one matrix material.

Abstract: An elongated intracorporeal device, more specifically, a balloon catheter having an elongate shaft with a distal section. The distal section of the shaft has a distal inner tubular member with an inflatable balloon disposed about the distal inner tubular member. A radiopaque marker formed at least in part of a polymer is disposed on the distal inner tubular member. The flexible radiopaque marker can be formed either by doping a desired portion of the distal inner tubular member with an appropriate radiopaque material, or preforming the radiopaque marker from a polymer doped with a radiopaque material and subsequently securing the radiopaque marker to the distal inner tubular member.

Abstract: A catheter assembly comprising a shaft and at least one flexible radiopaque marker affixed with the shaft. Flexibility of radiopaque marker is achieved by using a segmented band of radiopaque material or a coiled band formed by winding a wire or hollow tube filled with radiopaque material. The flexible radiopaque marker may be affixed with the shaft by an adhesive, by swaging, by crimping, by soldering, or by spring-action tension fit against the shaft.

Abstract: A thin-walled reinforced catheter shaft having polymers that are reinforced with a variable wire size radiopaque braid which maintains the thin-wall of the shaft while providing improved properties in terms of radiopacity, kink resistance, tortional rigidity, column strength and burst strength.

Abstract: A stent delivery device which includes a balloon having at least one radiopaque region or portion.

Abstract: A balloon catheter in which its distal tip is precisely positionable in order to control movement of the catheter through tortuous vasculature and especially through the lumen of a deployed stent is disclosed. The distal tip of the catheter is rendered radiopaque, at least at its distal-most end, to enable visualization of the position of the catheter and to facilitate placing the catheter in the desired position.

Abstract: An apparatus and method for treating a disease process in a luminal structure comprises a balloon catheter having a central balloon and two edge balloons. The central balloon may be separately inflated temporally and with different radioactive fluid than the edge balloons. Other arrangements include a wire, stent and concentric balloons, which provide spatial and temporal control enabling differential radioactivity at different spatial locations along the structure.

Abstract: A delivery catheter for a radially compressible tubular prosthesis comprises an elongate shaft slidably received within a tubular cover. The prosthesis is carried within a plurality of elongate, relatively hard runners, and is restrained in a radially compressed configuration by the cover. After introducing the catheter to a desired target location within a body lumen, the prosthesis may be released by proximally retracting the cover. The runners may optionally remain disposed about the prosthesis to be retracted separately, or, alternatively, the runners retract proximally with the cover as the prosthesis slides over the hard runner surfaces.

Abstract: A balloon catheter for use with a guidewire is disclosed. The catheter has a body with a balloon located thereon, preferably at the distal end. A lumen within the catheter body communicates with the interior of the balloon which can be inflated by known methods with saline solution. A series of sleeve members of predetermined lengths and sizes are coupled to and positioned along the length of the catheter body. One or more of the sleeve members can span the length of the balloon. Each sleeve member has a passageway and both an exit and entry port so that the guidewire can pass therethrough. Instead of a balloon, the catheter can include a device member that forms a chamber which can store medicine until discharged at the desired site within the blood vessel. Apertures or pores on the catheter body allow for the perfusion of blood or the delivery of medicine to the site of the blood vessel. A method of operation is also disclosed.

Abstract: The invention concerns a balloon catheter (1) for dilating vascular constrictions and for simultaneously introducing a permanently deformable stent (9) into the vessel to be dilated in order to stabilize it in the dilated condition, wherein the distal region of the catheter which is intended to receive the stent has an inner tube (2) which is surrounded by the non-expanded stent, the balloon (7) is arranged between the stent (9) and the inner tube (2) and the inner tube has at its ends as X-ray markings two sleeves (3, 4) which are carried thereon and which comprise an X-ray-opaque material and which are provided within the balloon on the inner tube, wherein provided between the inner tube and the outer balloon is a tube (5) which forms an additional plateau and which comprises a soft-elastic material as an intermediate layer, in such a way that it extends in the longitudinal direction to beyond the sleeves forming the X-ray markings.

Abstract: The present invention comprises a tubular catheter shaft defining at least one catheter shaft lumen and a radiopaque band made of a polymeric material loaded with a radiopaque material of greater than 40% by weight, suitable for visualization under fluoroscopy in catheters in the range of 3 French to 5 French. The distal soft tip is formed of a relatively flexible polymeric material, loaded with radiopaque material which is less radiopaque than the radiopaque band. The radiopaque band's proximal end adjoins the distal end of the catheter shaft. The radiopaque band's distal end adjoins the proximal end of the distal tip to form an attachment junction. A tubular sleeve fits coaxially over the radiopaque band, the distal end of the catheter shaft and the proximal end of the distal soft tip.