Abstract: A closure assembly for a syringe having a nozzle or access portion and a discharge port including a closure cap or syringe cap having a access engaging portion removably connectible in flow restricting relation to the discharge port. A connecting structure is mounted on the access engaging portion and disposed and configured to define an interactive engagement with an attachment structure of the nozzle or access portion of the syringe. Structural and operative features of the connecting structure enable a “push-on connection” of the closure cap or syringe cap to the nozzle or access portion and a “rotate-off disconnection” of the closure cap or syringe cap from the nozzle or access portion. The closure cap or syringe cap may be used independently of or in combination with an end cap and an included indicator member, wherein the combination closure cap or syringe cap and end cap define a tamper evident cap for the syringe.

Abstract: The present invention relates to a supplementary device for a manually operable injection device. The device has a body and a mating unit configured to releasably mount the body to the injection device in a specific position relative to an outside surface of the injection device.

Abstract: The present disclosure provides an access system having a maneuverable catheter assembly configured for providing access to and navigating a desired vessel for subsequent treatment thereof. The access system includes an adjustable delivery handle assembly and an access catheter subassembly having a maneuverable access catheter configured to be delivered to desired site (e.g., within duodenum) to assist in treatment of a condition (e.g., drainage of a bile ducts via Endoscopic Ultrasound Guided Biliary Drainage (EUS-BD) techniques). The access catheter includes at least a distal section having an adjustable portion along a length thereof configured to transition to a pre-defined arcuate shape to provide directional control over the distal end of the catheter as it is navigated through a vessel (e.g., bile duct). The handle assembly includes additional elements configured to allow a clinician to maneuver and manipulate the distal end of the access catheter.

Abstract: Applicator for injecting a bulking agent at one or more selected submucosal positions in a periurethral tissue of a female patients' urethra. The applicator comprises a lance, such as a cystoscope with a distal end provided with one or more optical sensors, and a needle guide with a bore receiving the lance. The needle guide comprises needle channels at different angular positions, each needle channel extending between a needle entrance surface and an opposite shoulder surface. The needle channels are oriented to direct a needle via external peripheral tissue of the urethral meatus to a submucosal position at a urethra section, e.g., within the optical scope of the optical sensor.

Abstract: There is provided a cassette unit suitable for use with an auto-injector. The cassette unit comprises a cassette unit housing and a removable cap that in a capping position fits over and thereby, acts to close off, a needle projection aperture of the housing. The cassette unit housing has one or more first engagement features arranged for reversibly engaging one or more second engagement features of the removable cap for reversible lock engagement of the removable cap to the housing; and a shuttle lock control defining one or more blocking elements for selectively blocking movement of said first engagement features relative to said second engagement features. The shuttle lock control is axially movable relative to the cassette unit housing between a first ‘cassette unused’ position; a second ‘cassette unlocked’ position; and after replacement of the removable cap, a third ‘cassette used’ position, locating intermediate the first and second positions.

Abstract: An infusion set or patch pump is provided for delivering a pharmaceutical agent, such as insulin, to a patient. The infusion set or patch pump has a recessed portion in the bottom face containing a hydrogel and a reactant capable of producing a color change upon contact with the pharmaceutical agent. The reactant includes a mixture of potassium persulfate and 4-aminoantipyrine and optionally horseradish peroxidase, and produces a rapid visually detectable color change when contacted with phenol and/or m-cresol contained in insulin as stabilizing agents.

Abstract: A drug reservoir comprises of a housing having a proximal end and a distal end, wherein the housing is configured to hold a medicament; and a removable feature disposed on at least one of the proximal end and the distal end, wherein the removable feature covers at least in part one of the proximal end and the distal end.

Abstract: A syringe assembly including: (1) a syringe barrel defining a chamber; (2) a plunger mounted in the chamber and moveable with respect to the barrel; and (3) a cap assembly containing a cap and an absorbent material is removably attached to the plunger. An antiseptic cap and syringe combination includes a syringe barrel having an access point connection, and a tip cap having a proximate chamber and a distal chamber. The proximate chamber releasably receives and engages the access point connection of the syringe, and the distal chamber removably receives and engages an antiseptic cap.

Abstract: An instrument, article and method are provided for minimizing pain during administration by injection of a liquid, such as, an anesthetic. The instrument has a forward end. A rod or lightpipe mounted freely for vibration projects out of the forward end. The article, a single use tip, is composed of a tip sleeve removably mounted on the forward end of the instrument and a tip member removably mounted on the projecting rod or lightpipe to vibrate a preselected injection site on a human or animal. The tip sleeve and tip member are covered by an elastic overmold that enables the tip member to vibrate freely with respect to the tip sleeve and light from the lightpipe to illuminate the injection site. The overmold of the single use tip is torn during removal of the single use tip from the instrument.

Abstract: Drug delivery device comprising expelling means allowing a user to set a dose corresponding to a number of increments from an initial state, an indication member adapted to rotate in a first direction corresponding to the set dose, and rotate in an opposed second direction corresponding to an expelled dose, the indication member having an initial rotational position corresponding to both the initial state and the fully expelled dose state. Sensor means having an incremental counter synchronized with the rotational position of the indication member and having a reference point corresponding to the initial rotational position of the indication member. After detecting an error state the sensor means is adapted to re-synchronize by detecting the number of rotational increments for a set dose and for a subsequent expelled dose. If the numbers are identical the reference point is reset corresponding to the current rotational position of the indication member.

Abstract: An exterior cap of transfer set for peritoneal dialysis, including: a cylindrical cap unit to which the end connector of the peritoneal transfer set is coupled; a guide unit that is coupled to the cap unit, extends to the peritoneal transfer set to provide an expanding internal space, and guides the end connector of the peritoneal transfer set into the cap unit; and a coupling-separating unit that combines the cap unit and the guide unit with each other and separates the cap unit and the guide unit in accordance with selection of a user.

Abstract: Embodiments are directed to infusion devices, systems, and methods to detect a capacity of a collapsible fluid reservoir of an infusion cartridge and/or a volume of a fluid disposed in the collapsible fluid reservoir or some other parameters of the infusion cartridge, and setting corresponding therapeutic parameters of an infusion device. Embodiments may include, obtaining data on the volume of fluid in the collapsible fluid reservoir, analyzing the obtained data to determine the setting of therapeutic parameters, and setting one or more therapeutic parameters of an infusion device.

Abstract: Methods and devices for metering and delivering a desired dose of medication from a syringe are described. The devices may include a dosage limiting sleeve adjustably disposed around a syringe body, wherein the alignment of the dosage limiting sleeve relative to the syringe body indicates the dose to be administered by depressing a plunger until the dosage limiting sleeve is engaged.

Abstract: A supplemental device for attachment to an injection device comprises an aligning arrangement for ensuring a predetermined positional relationship between the supplemental device and the injection device; and a securing arrangement for securing the supplemental device to the injection device.

Abstract: A closure assembly structured for use with a female luer connector and operative to indicate an accomplished or attempted tampering thereof. A connector cover is movably and removably disposed within a housing and includes an interior chamber disposed and structured to receive an access port of the female connector. An indicator member is removably connected to an interior of the housing in surrounding relation to the connector cover and a drive assembly associated with both the connector cover and the housing is operable to concurrently rotate and axially advance the interior chamber into enclosing relation to the access port. Attempted removal of the housing from the female connector, such as by an applied axial force to the housing, will detach the indicated member from the housing and dispose it in a visually observable position surrounding the connector cover, thereby indicating attempted access.

Abstract: A medicated module for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module containing a single dose of a secondary medicament and where both medicaments are delivered through a hollow needle. The medicated module is initially in a locked state until attached to a drug delivery where a locking plate is moved to a triggering state. The medicated module does not require the user to manually engage a reservoir containing the secondary medicament. Instead, a biasing member automatically activates the reservoir when the needle guard is retracted when the module is in the triggering state. The needle guard prevents accidental needle sticks before and after an injection, and locks after dose delivery.

Abstract: Medicament delivery device comprising a housing (10) and container holder (12) accommodating a multi-chamber medicament container wherein said housing and said medicament container holder are interactively connected to and movable relative each other; a mixing guard mechanism interactively connected to the body for driving the medicament container holder within the housing achieving a reconstitution, wherein the mixing guard mechanism comprises a guard member (34), a force member (52), a guard member locking means (24, 42) whereby, when the reconstitution is achieved, the medicament container holder and the guard member are movable in relation to said housing from a pre-mix position to a mixed position wherein said medicament container holder has been displaced distally in relation to said housing, at which mixed position said guard member locking means is activated, whereby said guard member is forced in the proximal direction by said force member for covering the delivery member (22).

Abstract: A delivery device includes a durable housing portion and a separable disposable portion that selectively engage and disengage from each other. The disposable housing portion secures to the patient and may be disposed of after it has been in use for a prescribed period. Components that normally come into contact with a patient or with infusion media are supported by the disposable housing portion for disposal after the prescribed use, while the durable housing portion supports other components such as electronics for controlling delivery of infusion media from the reservoir and a drive device and drive linkage.

Abstract: The invention is about a next-generation blood pump that provides pulsatile blood flow, and has been developed for cardiopulmonary by-pass devices used for maintaining extracorporeal blood circulation during heart surgeries and the supportive devices of circulation system. This device is technically a sort of synchronous power-assisted motor employing direct driver technology. The mentioned blood pump contains a rotor rotating on a magnetic bearing without a shaft and through the helical wings placed into the rotor it provides pulsatile blood supply adequate for the body requirement synchronous with the ECG signals received from the patients. It provides a patient safer and controlled pulsatile blood flow while running at high efficiency.

Abstract: A method for monitoring the status of an implanted catheter includes monitoring changes in pressure within a lumen of a catheter associated with physiological parameters (“physiological pressure”) and changes in pressure within the lumen of the catheter associated with bolus infusion of fluid into the catheter or bolus withdrawal of infusion from the catheter (“bolus pressure”). Methods that employ monitoring both physiological pressure and bolus pressure can provide information that cannot be obtained from monitoring physiological pressure or bolus pressure alone.

Abstract: The technical problem of the present invention to provide a medical device, which exhibits an increased safety of the device and facilitates a safe use is solved by medical device for delivering at least one drug agent, comprising a sensor, a control unit and an attachable dispense assembly, wherein the sensor is configured to detect attachment of the dispense assembly to the medical device, wherein the control unit is configured to determine at least based on a signal from the sensor whether the end of life of the dispense assembly is reached and wherein the medical device is configured to indicate the end of life of the dispense assembly. The technical problem is further solved by a method according to the invention.

Abstract: A system for occlusion detection could include a syringe pump for a syringe containing a medication, wherein the syringe includes a plunger and the syringe pump includes a plunger driver. A bendable element could be integrally formed with the plunger driver, and a force sensor could also be integrally formed with the plunger driver. Upon occurrence of an occlusion, the plunger would exert a force backwardly against the bendable element, thereby deflecting the bendable element into contact with the force sensor to thereby generate a signal indicating the occurrence of the occlusion.

Abstract: An apparatus and method are disclosed for providing a continuous and controlled flow of a fluid and/or gas or combination of them when using an irrigation system; said system comprises: a reservoir system comprising a plurality of containers of fluid; said containers in said reservoir system are disposed in a predetermined configuration; a fluid transfer system in fluid connection with said reservoir system, said fluid transfer system comprising: at least one fluid transfer head, adapted to transfer fluid from one of said plurality of containers to an external tubing system; wherein each of said fluid transfer heads is characterized by a mechanism adapted to radially or linearly move each of said fluid transfer heads.

Abstract: A method and apparatus are disclosed for delivery of a drug to a recipient. In some embodiments, the delivery apparatus may unseal a drug containing reservoir. In some embodiments, the delivery rate may be controlled and/or adjustable. Optionally the apparatus may be disposable. Optionally, the apparatus may have a low profile and/or be wearable and/or attachable to the recipient. Optionally, discharge of the drug and/or unsealing of the reservoir may be driven by a plunger moving parallel to the base of the apparatus. Optionally, the apparatus may release a hypodermic needle into the recipient. Optionally, release of the hypodermic needle may be in a direction non-parallel and/or orthogonal to the direction of movement of the plunger. Optionally, prior to release, the hypodermic needle may be preserved in an aseptic state by a needle opening septum sealing a needle opening. Optionally, upon release, the hypodermic needle may pierce the needle opening septum.

Abstract: A medicament delivery device has proximal and distal ends; a medicament container with a plunger, a neck portion, and a delivery member unit; a housing extending along a longitudinal axis with proximal and distal open ends; a drive unit configured to apply a force on the plunger; and a C-shaped tubular body with a longitudinal slit/gap such that body can be attached to the neck portion forming a container unit. The C-shaped body also has an inner support configured to interact with the neck portion and with the delivery member unit and prevent the medicament container from moving relative to the body after the medicament container is attached to the body, and outer support configured to interact with a corresponding support of the housing to prevent the C-shaped tubular body from moving relative to the housing after the container is arranged within the housing through the distal open end.

Abstract: A fluid transport apparatus includes: a first electrode provided on the insulating transporting tube which constitutes part of a flow channel in which conductive fluid is transported, and configured not to come into contact with the fluid in the flow channel a second electrode configured to come into contact with fluid in the flow channel; and a determining unit connected to the first electrode and the second electrode, and configured to determine a trouble of the transporting tube. Accordingly, the trouble of the transporting tube is determined.

Abstract: A therapeutic agent injection device including an injection device for delivering a therapeutic agent to a patient having a body, the body having a patient face and an port face opposite the patient face, the port face having an introducer port including an introducer channel and an injection port including an injection channel, the introducer channel being in fluid communication with the injection channel through a cross channel, the injection channel defining an injection axis; a delivery tube for subcutaneous delivery of the therapeutic agent to the patient, the delivery tube projecting from and being generally perpendicular to the patient face, the delivery tube defining an introducer axis and being in fluid communication with the injection port; and a patch, the patch being attached to the patient face and being operable to adhesively attach to the patient; wherein the injection axis is parallel to the introducer axis.

Abstract: An anesthetic administration device comprising an infusion device, which is in fluid connection with a regional anesthetic needle by means of a feed tube. The infusion device comprises one or more anesthetic flow devices capable of triggering forward flow, and optionally backward flow, of the local anesthetic through the regional anesthetic needle. Forward, and optionally backward flow, of the local anesthetic through the regional anesthetic needle is controlled by a controller that comprises one or more actuator switches. The one or more actuator switches are positioned on the device such that they may be operated by hand.

Abstract: A medical remote controller device is disclosed. The device includes a display and at least one input switch dedicated to bolus delivery wherein a bolus delivery is programmed when the input switch receives an input and wherein the number of inputs received by the input switch determines the amount of bolus to be delivered.

Abstract: An inserter and methods of using embodiments of the inserter are described. The inserter includes a housing having a cannula assembly and an insertion mechanism. Two buttons are located on the inserter and are concomitantly actionable for actuation of the insertion mechanism, wherein the insertion mechanism is configured to place a cannula assembly in a well that is disposed on the cradle. The inserter also includes a first parts and second part, whereby the first part includes a handle and the second part comprises the entire insertion mechanism, whereby the first and second part are connected via an indentation.

Abstract: Method for detecting an end-of-dose condition in a pressurized system, comprising the steps of (a) providing a system having a fluid-filled variable volume reservoir comprising an elastically deformable portion and an outlet, pressurizing means, and means for detecting a property of the elastically deformable portion which varies with the internal pressure in the reservoir, (b) pressurizing the reservoir to expel a desired amount of fluid by applying a force, thereby deforming the elastically deformable portion, (c) measuring, after the actuating step, a property related to the elastically deformable portion as it regains its initial configuration, (d) comparing a value for the measured property with one or more threshold values, and (e) providing a user with an indication when a given threshold value has been reached, and/or when a given threshold value has not been reached within a given period of time.

Abstract: A device for checking indwelling site capable of checking the indwelling site of a medical tube through multiple checking operations by simple techniques using a single device is disclosed. The device for checking indwelling site is provided with a barrel, a first plunger having a torso member and a hole formed communicating between the inner cavity of the torso member and the inner cavity of the barrel and disposed capable of pushing into or pulling out while keeping the barrel airtight, a second plunger having a second tip member and disposed capable of pushing into or pulling out while keeping the torso member airtight, a space formed between an inner wall and the tip face of the first tip member and designed to suck the gas fraction of the fluid sucked into the barrel into the torso member, and a detecting member arranged inside the torso member on the tip side of the second tip member and designed to react with carbon dioxide sucked in through the space by discoloring.

Abstract: An indicator dilution system includes a catheter configured to deliver an indicator to a patient, an injection device configured to deliver the indicator to the catheter, and a connector coupling the injection device to the catheter. The system also includes one or more sensors configured to acquire measurements from components of the system, which may be used to determine the start and end time of the injection of the indicator to the patient. For example, the one or more sensors may be configured to acquire signals relating to a state of the connector, which may be used to determine whether the connector is in an open state to enable flow of the indicator or in a closed state to reduce flow of the indicator.

Abstract: Medical device assemblies having a connection mechanism for securely connecting a hub to fluid storage containers in a luer slip relationship are described. An exemplary medical device includes a hub forming a cavity, a second indicating element disposed within the cavity that engages the hub. Additional features of the medical device include a second indicating element contoured to form a line contact with the hub. In a specific configuration, the hub includes a first indicating element attached to the hub and extending proximally into the cavity having a protrusion. In a more specific configuration, the medical device includes a fluid storage container that has an indication system for visually indicating optimal fluid-tight engagement of the hub and the fluid storage container.

Abstract: A passive safety device for a medical needle has a mount for supporting the needle and a needle shielding sleeve co-axial with and arranged for sliding movement relative to the mount, from a shielding position to a non-shielding position. An abutment surface is provided on one of the sleeve and mount and is engageable by a radially deformable finger, when undeformed. A control member is also slidably arranged with respect to the mount and sleeve and has an initial set position. The control member co operates with the finger so that on sliding movement of the sleeve from its initial shielding position, the finger is moved radially outwardly, clear of the abutment surface and on to a sliding surface.

Abstract: A self-injection device with a miniaturized drug delivery portion is provided. The device includes a housing (10) having an interior volume and the drug delivery portion (20) has a volume enclosed within the housing. The drug delivery portion includes a reservoir (30) containing a fluid to be delivered to a user and a microneedle (22) in fluid communication with the reservoir and extendable through the housing. The drug delivery portion also includes a drive mechanism for expelling fluid from the reservoir through the microneedle, wherein the volume of the drug delivery portion is less than 40% of the interior volume of the housing. The volume of the drug delivery portion may be less than 30% of the interior volume of the housing.

Abstract: This pharmaceutical injection device comprises a main body case; a pharmaceutical syringe mounting portion provided inside the main body case; a piston that is provided so as to be movable with respect to a pharmaceutical syringe that is removably attached to the pharmaceutical syringe mounting portion; a drive mechanism for driving the piston; a controller that is electrically connected to the drive mechanism; and an acceleration sensor that is connected to the controller. When a manual mixing mode of the pharmaceutical syringe is selected, the controller changes to the next step (air venting mode) if the inclination angle of the main body case sensed by the acceleration sensor is greater than a specific value.

Abstract: A connector mountable to a syringe barrel has a proximal barrel-engaging portion, a distal luer fitment portion, and a fluid aperture therethrough. The barrel-engaging portion of the connector includes an axial ledge configured to abut the axial distal edge of a glass syringe barrel. The connector facilitates mounting a luer assembly to the barrel. The luer assembly may be a tip cap having a complementary luer fitment for connection to the luer fitment portion of the connector. The luer assembly may be a luer needle assembly having a complementary luer fitment for connection to the luer fitment portion of the connector. The connector and syringe may further include an immobile, compressible needle seal. The needle seal is adjacent to or engageable with the barrel-engaging portion of the connector. The syringe may be configured with a plunger capable of engaging a retractable needle.

Abstract: The present invention relates to a medical delivery apparatus which comprises a hollow container (2) filled with a liquid drug (3). The container (2) is closed at its distal end by a pierceable membrane (4) and provided with a plunger at its proximal open. Whenever a piston rod (20) moves the plunger (5) forward inside the container, a pressure is build up in the liquid drug (3) contained in the container (2). Further, a resilient element (33),such as a spring, is provided. This resilient element (33) can be activated to operate from a relaxed state to a tensed state upon activation of a dose injection mechanism during injection. The resilient element (33) is operated to its tensed state when during injection, the pressure is build up in the liquid drug (3) and secured in its tensed state as long as the pressure inside the container (2) is above a predetermined threshold value.

Abstract: An improved pump, reservoir and reservoir piston are provided for controlled delivery of fluids. A motor is operably coupled to a drive member, such as a drive screw, which is adapted to advance a plunger slide in response to operation of the motor. The plunger slide is removably coupled to the piston. Methods, systems, and articles of manufacture for automatically detecting an occlusion in a medication infusion pump are provided. The electrical current to an infusion pump may be measured. Based on measurements of one or more variables, such as force, the infusion pump detects whether there is an occlusion in the system. The methods of detecting occlusions may be dynamic.

Abstract: A syringe includes a syringe outer tube including a tubular-shaped outer tube main body configured to be filled with a liquid, a reduced diameter section located at a distal end of the outer tube main body in a projecting manner, and configured to allow the liquid to pass therethrough, the reduced diameter section having an outside diameter that is smaller than a diameter of the outer tube main body, and a ring-shaped lock adapter concentrically disposed at an outer circumferential portion of the reduced diameter section and configured to fix a mating member connected to the reduced diameter section; and a cap including a cap main body mounted on the syringe outer tube and configured to seal the reduced diameter section in a liquid-tight manner when the cap main body is in a mounted state, a ring-shaped mounting section disposed at a proximal end side of the cap main body and mounted on an outer circumferential portion of the lock adapter, and a breaking section that forms a link between the cap main body and

Abstract: An apparatus 100 for use in tube feeding comprises a cylindrical body 110 provided with a first opening 120 and a second opening 130 connected by a flow channel 140. The body 110 comprises reagent 111, for determining a characteristic of fluid disposed in the body and a transparent window 112 through which the reagent 111 is visible. In use, a first end of an internal feeding tube releasably engages with the first opening 120. The second, distal end of said feeding tube is disposed inside a patient to be fed. A second feeding tube engages with the second opening 130. The second feeding tube connects the apparatus 100 to a bi-directional pump operable: to pump internal fluid from a reservoir, through the apparatus and into the internal feeding tube; and to pump fluid from the patient into the body 110 of the apparatus 100. This allows a user to pump fluid from the patient into the body 110 of the apparatus 100 to react with the reagent 111.

Abstract: A portable insulin pump can utilize readings from a sensor incorporated into an infusion set used with the pump to deliver insulin to a patient to determine if the infusion set is or is likely to become dislodged from the patient. Readings from the sensor that are inconsistent with expected readings or a range of expected readings can indicate that the infusion set has become dislodged from the patient.

Abstract: Methods and devices for drug infusion and for storing a drug container. The methods and devices can include ambulatory infusion systems and dosing units. The dosing units can have and an inlet port for attachment to an external liquid drug container, an outlet port, a pump kernel, and a control valve.

Abstract: The invention relates to a device for injection of a product into an injection site. The device including a needle shield for protection of a needle prior to use of the device; a housing; and a deshielder for removing the needle shield from the device. The deshielder is coupled to the needle shield and mounted on the housing in a separable manner. The deshielder may include tamper evidence features that are activated by the removal of at least one part of said deshielder. At least one part of the deshielder may be configured to be removed from the housing by exerting a force equal or less to 30 N.

Abstract: A tamper resistant/evident cap cover for IV needle configurations to provide a single use engageable cap to prevent unauthorized access and use of an IV needle port. The cap cover has a threaded IV needle receiving base and a slidably disposed interengagement locking clasp. Oppositely disposed tamper evident latching tabs are receivably secured into the base by multiple clasp barbs defining a first position for access and a second closed locked position.

Abstract: Technologies are generally described for a method and a device for detecting device colonization. Disclosed herein is an indwelling medical device configured to detect a biofilm. The device comprises a substrate configured to contact blood and a detecting material, disposed with the substrate, configured to detect the presence of a biofilm thereon. The detecting material is soluble in blood, removable by kidneys from the blood, and passable to urine by the kidneys for detection in the urine. A method for detecting the growth of a biofilm on an indwelling medical and a method for making an indwelling medical device are also disclosed herein.

Abstract: In one step of a method for infusing an infusion fluid, the infusion fluid is pumped through a fluid delivery line of an infusion system. In another step, measurements are taken with at least one sensor connected to the infusion system. In an additional step, an air determination is determined with at least one processor. The air determination is related to air in the fluid delivery line. The air determination is based on the measurements taken by the at least one sensor. The air determination is further based on: (1) medication information regarding the infusion fluid or infusion information regarding the infusion of the infusion fluid; or (2) multi-channel filtering of the measurements from the at least one sensor or non-linear mapping of the measurements from the at least one sensor; and statistical process control charts applied to the multi-channel filtered measurements or applied to the non-linear mapped measurements.

Abstract: Technologies are generally described for indwelling medical devices for detection of luminal catheter colonization. A substrate for use as an indwelling medical device includes an elevated biofilm releasing medium including a dye for release into urine on the occurrence of an elevated biofilm build-up on the substrate in the urine; and an elevated pH releasing medium including a dye on the substrate different from the dye used to detect biofilm build-up for release into urine on the occurrence of an elevated pH level in the urine. Methods of manufacture and use of the disclosed indwelling medical devices are also described.

Abstract: A closure for closing in a sealing manner a distal opening on a syringe body is provided. The closure includes a fastening element that is or can be arranged on the syringe body around the distal opening and a closure cap that can be loosely connected to the fastening element and closing in a sealing manner the distal opening. The fastening element includes an inner thread that intermeshes with an outer thread on the closure cap, resulting in an initial state wherein the outer thread is formed on at least part of the closure cap. The part is under tension in such a way that after the closure cap is unscrewed from the inner thread the part under tension is pressed out over the inner thread of the fastening element such that the closure cap cannot be returned to the initial state once the closure cap is unscrewed.