Abstract: Aspects of the present disclosure relate to systems and methods for injection and retraction of a fluid. The system includes a switch configured to be activated, wherein activation of the switch activates an electrical control system. The system further includes a linear actuator that interfaces with the electrical control system. The electrical control system causes the linear actuator to depress a plunger, keep the plunger depressed for a predetermined time, and retract the plunger after the predetermined time. The system further includes a fluid reservoir engageable with the plunger, wherein the depression of the plunger causes fluid to be injected from the fluid reservoir into a connector and the retraction of the plunger causes fluid to be retracted into the fluid reservoir and out of the connector.

Abstract: A system for monitoring and maintaining an intravascular assembly is provided. The system comprises a robotic device. The robotic device includes an optical sensor configured to detect an errant flow in at least a component of the intravascular assembly, and a pressure sensor that is configured to manipulate at least the component of the intravascular assembly to restore, start, stop flow, or change at least the component of the intravascular assembly.

Abstract: A fluid trap is disclosed herein. The fluid trap has a reservoir housing defining a reservoir and a tube connector coaxially disposed through the reservoir housing. The tube connector has first and second connector ends extending from opposing sides of the reservoir, an interior passageway in fluid communication with the first and second connector ends, and an aperture in fluid communication with the reservoir. The reservoir is in fluid communication with the interior passageway and is configured to retain fluid from that passageway.

Abstract: Systems and methods for the intravascular treatment of clot material within a blood vessel of a human patient are disclosed herein. A method in accordance with embodiments of the present technology can include, for example, engaging an interventional device of a catheter system with clot material in a blood vessel and withdrawing the interventional device and the portion of the clot material through a guide catheter. In some embodiments, the catheter system can include an attachment/valve member coupled to a proximal portion of the guide catheter, and the method can include unsealing the attachment/valve member to facilitate withdrawing the interventional device through the attachment/valve member without significant retention of clot material within the attachment/valve member. The method can further include resealing and aspirating the guide catheter before advancing another interventional device to the clot material to again engage and remove clot material from the blood vessel.

Abstract: Wound dressings for use in cases of a patient suffering a penetrating chest trauma. The wound dressing includes a base layer having a lower surface facing the wound and an upper surface facing away from the wound, and an aperture therethrough for locating over the wound, and a top layer extending over the aperture and at least a part of the upper surface. The base layer is connected to the top layer such that the wound dressing can transition from an open configuration in which the aperture and an area external to the wound dressing are in fluid communication via at least one opening at a perimeter between the base layer and the top layer, to a closed configuration in which the top layer forms a seal over the aperture.

Abstract: A system for delivering fluid to a user transcutaneously includes a subcutaneous infusion cannula base assembly, a cannula inserter assembly and a fluid connection assembly. The subcutaneous infusion cannula base assembly is configured to be located on the user's skin. The cannula inserter assembly is coupled to the cannula base assembly and is configured to drive an infusion cannula through the user's skin in a nominally helical trajectory. The fluid connection assembly is configured to fluidically connect the cannula base assembly to a source of delivery fluid. Cannula and stylet assemblies configured for helical or non-helical insertion are also disclosed.

Abstract: Methods and devices for treatment of damaged tissue are disclosed, including treatment of wounds by employing non-electrically powered, reduced pressure therapy devices. Maintenance and control of the sub atmospheric pressure exerted may be provided by such devices while minimizing discomfort to the user. The devices may be configured to be worn inconspicuously underneath clothing.

Abstract: A medical device having an antimicrobial coating on a surface of the medical device and an inserter device for subcutaneously inserting the medical device. The inserter device includes an outer part having one or more locking elements including a first locking element and one or more release elements including a first release element; a housing; and a functional part accommodated in the housing. The housing includes a sidewall with an inner surface forming a cavity, the housing extending from a first end to a second end along a first axis and comprising one or more housing guide members including a first housing guide member for engagement with one or more guide members of the functional part. The functional part comprises a first part with a first body extending from a first end to a second end along the first axis.

Abstract: A piston having a longitudinal axis and opposing proximal and distal axial ends is manufactured by a method including molding a partially formed piston body and then molding the piston. The partially formed piston body is molded by placing a first rubber sheet and an inert film between die plates of a first forming tool, vulcanizing the first rubber sheet and the inert film between the die plates of the first forming tool, and blanking out the partially formed piston body from the first rubber sheet and the inert film. The piston is then molded by placing the partially formed piston body into a second forming tool, placing a second rubber sheet into the second forming tool, vulcanizing the second rubber sheet and the partially formed piston body together, and blanking out the piston from the second rubber sheet at a trim edge spaced apart from the inert film.

Abstract: An optical operating fluid detector for optical detection of operating fluid for a hand-guided garden, forestry and/or construction machining appliance includes a light source, an operating fluid line and a light receiver. The light source is designed for radiation of rays of light. The operating fluid line is designed for optical interaction of rays of light from the light source with operating fluid in line for the optical detection of operating fluid. The light receiver is designed for differing reception of rays of light from the line in dependence on the presence or the absence of operating fluid in the line. The operating fluid detector has an optical deflecting device. The deflecting device is designed for deflection of rays of light from the light source to the operating fluid line and/or for deflection of rays of light from the line to the light receiver.

Abstract: Various systems and methods for detecting air in a chamber of an infusion system are disclosed. In one embodiment, a determination is made that air is contained in the chamber on the basis of a change in the average force exerted against the plunger utilizing a derivative spike for event detection and a systematic reduction in the average force to confirm the nature of the change. In another embodiment, a determination is made that the chamber contains air when a difference between the current force profile and a baseline force profile crosses a threshold. In an additional embodiment, a force profile is classified as being an air force profile or a liquid force profile based on extracted features of the force profile.

Abstract: A medicine delivery and tracking system includes a medicine injection pen and a delivery port. The pen includes a needle through which medicine is dispensed and an electronic unit configured to at least one of log dispensing of medicine from the pen, control dispensing of medicine from the pen, or communicate regarding dispensing of medicine from the pen. Alternatively, the electronic unit may be part of a separate computing device. The delivery port is configured for attachment to a user and to receive the needle of the pen such that medicine dispensed from the pen is dispensed into the delivery port and through the delivery port to the user. The delivery port includes a detector mechanism configured to detect a presence of the pen and, in response thereto, to communicate a signal to the electronic unit for use in the at least one of logging, controlling, or communicating.

Abstract: Systems and methods for the intravascular treatment of clot material within a blood vessel of a human patient are disclosed herein. A method in accordance with embodiments of the present technology can include, for example, engaging an interventional device of a catheter system with clot material in a blood vessel and withdrawing the interventional device and the portion of the clot material through a guide catheter. In some embodiments, the catheter system can include an attachment/valve member coupled to a proximal portion of the guide catheter, and the method can include unsealing the attachment/valve member to facilitate withdrawing the interventional device through the attachment/valve member without significant retention of clot material within the attachment/valve member. The method can further include resealing and aspirating the guide catheter before advancing another interventional device to the clot material to again engage and remove clot material from the blood vessel.

Abstract: The application discloses an assembly including a compressible bag and an apparatus for dispensing a liquid from a bag. The apparatus includes a housing with a dispensing end and an opposite rear end, a bottom part and top part and two side parts. A roller arrangement and a pair of steering tracks are mounted in a track length direction on the side parts, and the roller arrangement includes at least a front roller adapted to roll from the rear end towards the dispensing end. The surface of the roller is adapted for engagement with the compressible bag placed on the bottom part, and a gap is provided between the bottom part and the surface of the front roller, the gap being in the range of 2 to 10 mm where the surface of the front roller is closest to the bottom part.

Abstract: An IV access device can include a needle hub that incorporates a flash chamber. The flash chamber can be used to provide visual confirmation of proper catheter placement within a vein. The flash chamber can include a path-defining structure to facilitate identifying whether blood is continually flowing into the flash chamber. The flash chamber may also be removable from the needle hub. In some cases, the needle hub may include a paddle grip that facilitates insertion of the catheter and separation of the needle hub from the catheter adapter.

Abstract: A primer may be used with IV catheter systems. The primer may be positioned along the tubing of an extension set such that the primer divides the IV catheter system into a downstream portion and an upstream portion. The primer may vent air from both the upstream and downstream portions to allow blood to flow up to the primer while also allowing priming solution to flow down to the primer. As a result, the catheter may be inserted into the patient's vasculature without first priming the catheter. Once the air has been vented from the upstream and downstream portions of the IV catheter system, the primer may be actuated to open a fluid pathway through the primer. With the fluid pathway opened, the priming solution may commence flowing towards the patient's vasculature thereby flushing the blood from the IV catheter system.

Abstract: A system and method removing air from a reservoir, the system comprising the reservoir that carries a medicament, a first pump connected to the reservoir that draws the medicament out of the reservoir, an air removal device connected to the first pump that releases air from the medicament, and a second pump connected to the air removal device that delivers the medicament.

Abstract: A gas elimination apparatus and a method for use in an intravenous delivery system are provided. The apparatus includes a fluid inlet coupling a fluid flow into a liquid chamber, a fluid outlet protruding into the liquid chamber, and a flow diversion member proximal to the fluid outlet. The flow diversion member configured to block a direct flow between the fluid inlet and the fluid outlet. The apparatus includes a membrane separating a portion of the liquid chamber from an outer chamber and a gas venting valve fluidically coupling the outer chamber with the atmosphere. The flow diversion member may be mechanically supported by at least one strut or elongate member extending along a flow direction into the liquid chamber.

Abstract: Methods and apparatus to reduce deadspace in syringes and other devices with the use of volume displacing members that occupy space within one or more interior spaces of such devices. The volume displacing members are also equipped with one or more internal flow passages that facilitate a flow of a fluid through it. The volume displacing members are also adapted to cooperate with features of the devices that house them to form air-tight and liquid-tight seals that at least partially determine a fluid pathway through the devices.

Abstract: Methods and apparatus to reduce deadspace in syringes and other devices with the use of volume displacing members that occupy space within one or more interior spaces of such devices. The volume displacing members are also equipped with one or more internal flow passages that facilitate a flow of a fluid through it. The volume displacing members are also adapted to cooperate with features of the devices that house them to form air-tight and liquid-tight seals that at least partially determine a fluid pathway through the devices.

Abstract: A prepackaged needleless intravenous line assembly is provided as well as a method of delivering intravenous medication and/or fluid to a patient while maintaining sterility of needleless access ports. The pre-packaged needleless intravenous line assembly is a sterile intravenous line with at least one sterile access port, each access port having a disinfection cap installed thereon, sealed within a pouch with at least one strip of multiple sealed disinfection caps. An intravenous tubing kit, having sterile intravenous tubing with capped sterile access ports as well as sealed replacement disinfection caps, is removed from the package and attached to a patient's intravenous catheter. A disinfection cap is removed from the sterile access port. Medication and/or fluid is administered into the access port. A replacement disinfection cap is installed onto the access port.

Abstract: An IV catheter system may have a catheter component with a catheter hub, a cannula extending distally from the catheter hub, and a push feature adjacent to the catheter hub. The IV catheter system may also have a needle component with a needle hub, a needle extending distally from the needle hub along an axis, and a grip extending from the needle hub, generally parallel to the axis, with a pull feature. In the insertion configuration, the needle may be positioned within the cannula and the distal end of the needle hub may be seated in a needle port of the catheter hub. In the fluid delivery configuration, the needle may be positioned outside the catheter hub. The push and pull features may be positioned to facilitate manipulation with a single hand to move the IV catheter system from an insertion configuration to a fluid delivery configuration.

Abstract: Reservoir systems with improved wake up and fill volume detection techniques are provided. An example reservoir system may include a flexible reservoir and electrical components for detecting fill volume of the flexible reservoir without adversely affecting performance of the flexible reservoir when receiving or dispensing a liquid drug.

Abstract: A pharmaceutical syringe piston having a longitudinal axis includes a body having a central face portion with a first outer circumference and maximum first diameter. A cylindrical sealing portion proximate the central face portion has first and second axial ends and a wall extending therebetween. The wall has a second outer circumference and a second diameter essentially constant along the longitudinal axis between the first and second axial ends of the cylindrical sealing portion and is larger than the maximum first diameter. An annular curved portion has a maximum outer diameter less than the second diameter and connects the first axial end of the cylindrical sealing portion to the first outer circumference. An inert film encloses the central face portion and at least part of the annular curved portion and has an outer boundary between the first axial end of the cylindrical sealing portion and the first outer circumference.

Abstract: A method of balancing a heating system with a flow system, including a supply flow line (60) and a return flow line (70), a heat source (55) and a pump (10) hydraulic lines (L1-Ln), some having a heating element (H1-Hn) with a balancing valve (V1-Vn). The method includes: carrying out one or more measurements by opening one hydraulic line only and determining a flow rate through the pump and a pressure difference across the pump, establishing a hydraulic model based on the determined flow rate and pressure difference from at least two measurements from step, and at least one additional measurement for at least two hydraulic lines, specifying a desired flow rate for each of the hydraulic lines, and adjusting one or more of the dedicated balancing valves in order to meet the desired flow rate for each of the hydraulic lines by using the hydraulic model.

Abstract: An ion exchanger includes a case and a cartridge. The case has an opening open upward. The cartridge is detachably attached to the case through the opening and includes a circumferential wall, a top wall, a lower opening, and a porous body. The cartridge accommodates an ion exchange resin. The porous body closes the lower opening of the cartridge and allows coolant to pass through while not allowing the ion exchange resin to pass through. A discharge hole that allows air inside the cartridge to be discharged out of the cartridge is formed in at least one of the top wall of the cartridge or a portion of the circumferential wall of the cartridge that is opposed to the inner circumferential surface of the case body.

Abstract: An infusion pump includes inlet and outlet valves and a squeezing element configured to squeeze a fluid line coupled to the infusion pump. A method includes at least one round of valve operation check prior to initiation of a delivery session of fluid to a subject, and subsequently, after an intake phase and before a delivery phase of at least one infusion pump cycle, determining for the at least one pump cycle, an absolute amount of air in the fluid line. The valve operation check and the determining of the amount of air each include: (A) closing the inlet valve to confine a section of the fluid line between the inlet and outlet valves; (B) squeezing the confined section; (C) measuring the pressure within the confined section; and (D) subsequently, relieving the pressure in the confined section. Other applications are also described.

Abstract: An apparatus having an outer wall that encompasses an interior chamber that holds a predetermined volume of fluid and gas where the gas rises to one end of the interior chamber and the fluid flows to the other end of the interior chamber. The apparatus also has an inlet port that allows for fluid to ingress into the interior chamber and an outlet port that allows for fluid to egress out of the interior chamber.

Abstract: Disclosed is a fluid dispensing device that includes at least one reservoir to hold the therapeutic fluid, at least one other unit requiring communication with ambient air, at least partly, to operate, and at least one housing defining an interior to retain the at least one reservoir and the at least one other unit. The at least one housing has at least one vent port formed on one or more of its walls. The at least one vent port is adapted to direct or communicate air to maintain pressure equilibrium between the air pressure in the interior of the at least one housing and the ambient air pressure outside the at least one housing, and provide communication with the ambient air to the at least one other unit requiring air to enable operation of the at least one other unit.

Abstract: In part, the disclosure relates to an aspirator having a handle that includes a suction connector extending from a proximal end face, a substantially cylindrical sleeve mount having an outer surface and a shoulder. A tubular member defining a bore and having flared end disposed in a suction head having one or more cantilevered protuberances can extend from the sleeve mount. The substantially cylindrical sleeve mount is in relief with respect to the shoulder and extends distally therefrom. The substantially cylindrical sleeve mount defines an aperture. The suction connector bore, bore of tubular member, inner cavity of handle and suction head bore define a fluid flow path or cavity. The aspirator can include a sleeve that receives the suction head. The sleeve engages and interferes with the sleeve mount. The suction head and sleeve's inner wall have one or more engineered clearances between them to enhance assembly.

Abstract: The present invention includes methods, circuits, devices, assemblies, systems and associated computer executable code for monitoring medical conduits, sensing and measuring parameters of fluids (liquid and/or gas) within medical conduits and/or processing sensed/measured parameters of fluids within medical conduits. The present invention further includes medical infusion devices and/or systems including the monitoring, sensing, measuring and analyzing devices and methods described herein.

Abstract: An air removal device for an intravenous fluid system includes a housing with an inlet for fluid communication with a fluid source, a fluid outlet for fluid communication with a blood vessel of a patient, and an air outlet. The air removal device further includes a disrupting element disposed within the housing in a flow path between the inlet and the fluid outlet, and an air chamber in fluid communication with the air outlet. The disrupting element includes a protrusion extending across the flow path. The flow path includes a first cross-sectional flow area at the inlet, and a second cross-sectional flow area at the protrusion. The second cross-sectional flow area is smaller than the first cross-sectional flow area.

Abstract: Catheter adapters and vascular access device including catheter adapters are discloses. The catheter adapter tip opening has an internal curvature defining a tapered region in the lower portion, but not the upper portion, to support a flexured portion of the catheter to prevent kinking and occlusion.

Abstract: Methods and devices for treatment of damaged tissue are disclosed, including treatment of wounds by employing non-electrically powered, reduced pressure therapy devices. Maintenance and control of the sub atmospheric pressure exerted may be provided by such devices while minimizing discomfort to the user. The devices may be configured to be worn inconspicuously underneath clothing.

Abstract: In part, the disclosure relates to an aspirator having a handle that includes a suction connector extending from a proximal end face, a substantially cylindrical sleeve mount having an outer surface and a shoulder. A tubular member defining a bore and having flared end disposed in a suction head having one or more cantilevered protuberances can extend from the sleeve mount. The substantially cylindrical sleeve mount is in relief with respect to the shoulder and extends distally therefrom. The substantially cylindrical sleeve mount defines an aperture. The suction connector bore, bore of tubular member, inner cavity of handle and suction head bore define a fluid flow path or cavity. The aspirator can include a sleeve that receives the suction head. The sleeve engages and interferes with the sleeve mount. The suction head and sleeve's inner wall have one or more engineered clearances between them to enhance assembly.

Abstract: Disclosed are devices, systems, and methods for providing access to a patient. The patient access device comprises a proximal end, a distal end and a lumen therethrough. The patient access device further comprises a hollow shaft, an input port and a liquid supply port. At least a portion of the lumen passes through the shaft. The input port is coupled to the lumen, and the lumen and the input port are constructed and arranged to receive an elongate probe. The liquid supply port is in fluid communication with the lumen. The patient access is constructed and arranged to reduce gas from exiting the distal end while a portion of the elongate probe is positioned in the patient access device.

Abstract: A dialysis catheter includes an entirely subcutaneous first section, with an exterior interface via penetration of the overlying subcutaneous skin layer. In addition the first section of the dialysis catheter includes a detachable portion that enables insertion via a guidewire instead of a peel-away sheath. The dialysis catheter has a layered design that minimizes risk of infection.

Abstract: Embodiments of the invention provide methods and devices for improved drainage systems and tubing. In one embodiment, a context-sensitive flow interrupter is provided that inhibits or facilitates flow of fluid when engaged with a mating holder. In another embodiment, outflow is optimized through control of the pressure in gas pockets in a tube, drainage tube or assembly. In one such embodiment, gas pockets are vented to inhibit excessive back-pressure or suction on an organ, vessel or cavity being drained. In another such embodiment, loops in the tubes are avoided by using a mechanical template in the form of a groove or peg assembly to thread the slack in the drainage tube to generate a monotonic gradient. In another embodiment, such as for active drainage systems, a bypass channel is provided that allows an applied vacuum to go around an obstruction created by the collection of fluid in an undrained dependent loop.

Abstract: An IV access device can include a needle hub that incorporates a flash chamber. The flash chamber can be used to provide visual confirmation of proper catheter placement within a vein. The flash chamber can include a path-defining structure to facilitate identifying whether blood is continually flowing into the flash chamber. The flash chamber may also be removable from the needle hub. In some cases, the needle hub may include a paddle grip that facilitates insertion of the catheter and separation of the needle hub from the catheter adapter.

Abstract: Systems and methods are provided for intermittent microinfusion. A system may include a pump and an IV set that includes a y-port valve disposed below a pump interface portion of the IV tubing. The y-port valve may include an internal valve member that allows fluid to flow from the pump to a patient when no syringe is attached to the y-port. The internal valve member may be moved by the attachment of a syringe containing the medication to be infused to the y-port such that the fluid pathway from the pump to the patient is blocked and fluid from the syringe can be injected into the IV tubing between the y-port valve and the pump. The pump may retrograde pump the medication into the tubing via the y-port valve and then forward pump the medication to the patient when the syringe is removed from the y-port.

Abstract: A veno-arterial extracorporeal membrane oxygenation system includes a dual lumen drainage cannula configured for withdrawing blood from a patient's vasculature in a manner that provides a perfusion of oxygenated blood with reduced carbon dioxide content while unloading the left ventricle, with two points of access to the patient's vasculature. The dual lumen drainage cannula has a first drainage tube and a second drainage tube co-axially aligned with the first drainage tube. The first and second drainage tubes are fluidly coupled to a connector. A blood pump having a pump inlet is configured for fluidly connecting with the connector, while an oxygenator having an oxygenator inlet is configured for fluidly connecting with a pump outlet. An infusion cannula is configured for fluidly connecting with an oxygenator outlet for infusing oxygenated blood into a patient's bloodstream.

Abstract: Disclosed is a disposable needle filter apparatus with a universal truncated syringe-receiving neck to enable the filtration of fluids/solutions aspirated into a needle-bearing syringe. The apparatus includes a needle seal stopper and needle stop to create a substantially airtight chamber to facilitate fluid aspiration through an enclosed filter and into the syringe. In an alternative embodiment, the filter apparatus includes an extended syringe-receiving neck configured to receive a specifically sized syringe/needle combination. In a further embodiment, the receiving neck is constructed as a modular unit to allow for interchangeable necks to accommodate different needle and syringe sizes with different cross-sectional diameters. In a yet further embodiment, the neck is constructed with stepped tapered segments of serially larger cross-sectional diameters to accommodate differently sized syringes. In a still further embodiment, the apparatus includes an accessory needle secured to the apparatus inlet.

Abstract: An infusion pump device and method for filling a fluidic system of the infusion pump with liquid medicament prior to infusion operation is presented. A control unit causes the infusion pump to: (a) bring a pump to an initial state; (b) switch a valve to a first state connecting a secondary reservoir to a first conduit and a primary reservoir; (c) retrieve medicament from the primary reservoir; (d) switch the valve to a second state connecting the secondary reservoir to a second downstream conduit; (e) expel the secondary reservoir contents into the second downstream conduit; (f) switch the valve to the first state; (g) retrieve the primary reservoir medicament; (h) switch the valve to the second state; and (i) expel the secondary reservoir contents into the second downstream conduit by shifting a piston to the initial position.

Abstract: An IV catheter system may have a catheter component with a catheter hub, a cannula extending distally from the catheter hub, and a push feature adjacent to the catheter hub. The IV catheter system may also have a needle component with a needle hub, a needle extending distally from the needle hub along an axis, and a grip extending from the needle hub, generally parallel to the axis, with a pull feature. In the insertion configuration, the needle may be positioned within the cannula and the distal end of the needle hub may be seated in a needle port of the catheter hub. In the fluid delivery configuration, the needle may be positioned outside the catheter hub. The push and pull features may be positioned to facilitate manipulation with a single hand to move the IV catheter system from an insertion configuration to a fluid delivery configuration.

Abstract: This invention is an air block for industrial, medical, and non-medical uses. For example, the air block is connected to the proximal end of a vascular access catheter. The air block is either removably connected to the proximal end of the catheter or it is integral to the proximal end of the catheter. The air block permits introduction of other catheters or instrumentation through its central lumen and on into a lumen of the catheter while minimizing fluid loss or gain into the catheter. The air block further prevents air from entering the catheter and provides for removal of the air or other gas from the central lumen before it can enter the catheter where it could cause harm to the patient. The air block can be attached to various standard proximal catheter terminations including Luer fittings and hemostasis valve outer barrels.

Abstract: A fluid control component configured for controlling fluid flow through the hub of a catheter assembly during and after placement into the patient is disclosed. In one embodiment, the fluid control component comprises a body disposed within a cavity of the hub, the body being movable between a first position and a second position, wherein the body does not pierce a valve disposed in the hub when in the first position and wherein the body pierces the valve when in the second position. The body includes a conduit to enable fluid flow through an internal portion of the body when the body is in the second position, and a plurality of longitudinally extending ribs disposed on an exterior surface of the body. The ribs provide at least one fluid flow channel between the valve and an external portion of the body when the body is in the second position.

Abstract: An electroporation apparatus and its novel chamber with inlet ports for mixing cells and exogenous material. The inlet ports are oriented in nonparallel to each other immediately adjacent at the same top corner of the first wall of the chamber. The mixing chamber comprises successive wall sections, two curved walls at its bottom; the first curved corner is on the same side of the chamber where the liquids enter the chamber, and directs the liquids to the second curved corner at the opposing side of the chamber which in turn further redirects the mixing to the first curved corner. The direction of the liquid flow mixture change direction at least twice into the mixing chamber.

Abstract: A delivery system is provided that includes a device having a body extending along a longitudinal axis between proximal and distal ends. The body includes a proximal chamber, a distal chamber and a wall between the chambers. The body includes a first port in communication with the proximal chamber and a second port in communication with the distal chamber. A shaft is movably positioned within the body. The shaft extends through the wall and includes a proximal plunger positioned within the proximal chamber and a distal plunger positioned within the distal chamber. Pressure introduced through an opening in the proximal end moves the shaft such that the proximal plunger moves a fluid within the proximal chamber out of the first port and the distal plunger moves a fluid within the distal chamber out of the second port to simultaneously actuate a bone filler dispenser. Systems and methods are also provided.

Abstract: Embodiments of an actuated cannula seal are disclosed In some embodiments, a cannula seal includes a base portion that engages with a cannula; and a seal portion integrally formed with the base portion, the sealing portion capable of engaging with an instrument shaft, the sealing portion capable of being actuated by an actuator so that the sealing portion is continually in motion relative to the instrument shaft. The actuation of the sealing portion can be accomplished by rotation or vibration of the sealing portion relative to the instrument shaft.

Abstract: A two-part bioactive agent delivery system, the system including a disposable part comprising an agent reservoir, a bolus chamber, the volume of the bolus chamber being less than the volume of the agent reservoir, an agent outlet, and a valve having a first position communicating the agent reservoir with the bolus chamber and a second position communicating the bolus chamber with the outlet; and a reusable part including a valve driver, a power source and control electronics, the control electronics being adapted to control the valve driver to actuate the valve to deliver bioactive agent from the agent reservoir to the agent outlet; the system further having a spring extending between the agent reservoir piston and a surface of the reusable part or of the disposable part to pressurize the agent reservoir when the spring is compressed and the agent reservoir contains a quantity of bioactive agent.