Abstract: Systems and methods for injecting a drug and detecting tissue induced back pressure are disclosed. A drug delivery system may include a reservoir filled or fillable with a drug, an administration member connected or connectable in fluid communication with the reservoir, a drive assembly, and a pressure sensor. The administration member may be configured for insertion into and subsequently retraction from a patient. The drive assembly may be configured to urge the drug from the reservoir to deliver a dose of the drug to the patient via the administration member. The pressure sensor may be configured to detect tissue back pressure during use of the drug delivery system, including after dose completion and prior to retraction of the administration member. The drug delivery system may be controlled in a manner that accounts for the tissue back pressure measurement.

Abstract: The injection apparatus 100 is provided that can allow repair or replacement of an actuator 130 while maintaining a drip-proof state, and that can further maintain the drip-proof state without a cover. The injection apparatus 100 includes a syringe holder 110 on which a syringe filled with a liquid medicine is mounted, a presser 115 that pushes out the liquid medicine from the mounted syringe, an actuator 130 that moves the presser 115 forward or backward, the actuator 130 including a feed screw nut 134, a feed screw shaft 133, a motor 132, and a transmission mechanism 180 that transmits rotation from the motor 132 to the feed screw shaft 133, wherein the feed screw nut 134, the feed screw shaft 133, the motor 132, and the transmission mechanism 180 are housed in a case 170 of the actuator 130.

Abstract: A computer-controlled injector for use with a medicament cartridge and including a housing having a medicament cartridge receiving volume and a medicament cartridge insertion and removal opening communicating with the medicament cartridge receiving volume; a pivot mount element mounted onto the housing for selectably enabling access to the medicament cartridge receiving volume via the opening; a mechanical latch selectably locking the pivot mount element in a closed operative orientation; and an injection drive mechanism including a computer-controlled motor for driving a piston, forming part of the medicament cartridge, for injecting a medicament, the computer-controlled motor also being operative for operating the mechanical latch.

Abstract: Disclosed is a method for scheduling a refilling of a secondary reservoir of an ambulatory infusion system out of a primary reservoir storing a liquid drug. The method includes repeatedly and automatically carrying out a filling volume assessment routine. The filling volume assessment routine includes: determining, at a present point in time, an estimated filling volume of the secondary reservoir at a future estimation point in time, the future point in time being an estimation time interval after the present point in time, and determining in dependence of the estimated filling volume, if the secondary reservoir shall be refilled at the present point in time.

Abstract: A chemical-liquid injector includes a piston-driving mechanism (130) that moves a piston member of a syringe containing a contrast medium, which includes an actuator and a ram member which is moved back and forth by the actuator, a control circuit (150) which is electrically connected to the actuator, and an operating knob unit (170) which includes an operating knob that is to be operated by an operator, and a rotation sensor that outputs an electric signal corresponding to a rotation of the operating knob. The control circuit is configured to generate a predetermined control signal accordingly, on the basis of a signal from the rotation sensor, and the piston-driving mechanism is operated according to the control signal.

Abstract: A controller controls a fluid pump to deliver primary fluid from a first source at a desired rate through a respective conduit to a recipient. The controller monitors a volume of the primary fluid injected into the conduit. Subsequent to injecting a predetermined amount of the primary fluid into the conduit, the controller i) discontinues injection of the primary fluid into the conduit and ii) injects a secondary fluid through the conduit to advance a remaining portion of the primary fluid in the conduit to the recipient. The controller advances the secondary fluid into the conduit until a desired amount of the primary fluid is delivered trough the conduit to the recipient. Injection of the secondary fluid to push the remaining portion of the primary fluid reduces waste associated with the primary fluid.

Abstract: In some embodiments, apparatuses and methods are provided herein useful to provide fluid nutrition and hydration. In one illustrative example, a feeding set for use with a peristaltic enteral feeding pump has sections of flexible tubing or conduit, a dispensing control valve that is in fluid communication with the tubing, and a retention disk. In some configurations, the feeding set has as attachment mechanism, which may be formed by one clips or hooks extending from the dispensing control valve and coupling geometry of the retention disk. By some approaches, the clips or hooks and the coupling geometry are configured to attach the feeding set with the pump, such as by attaching the feeding set to an internal panel of the feeding pump. In operation, the feeding set and pump are used to move fluid nutrition and hydration from a container or bag to the patient in a controlled manner.

Abstract: A fluid injection system that includes an injector head having a syringe for delivering a fluid to a patient; a mounting structure pivotally connected to the injector head and configured to support the injector head above a surface; and a control system operationally coupled to the injector head for controlling an injection procedure is disclosed. The fluid injection system is provided with various sensors to control various aspects of the fluid injection system, such as the establishment of a reference plane, the determination of a tilt angle of the injector head, and the determination of a temperature of an actuation system of the injector head.

Abstract: A method for clearing a wetted hydrophobic filter includes a first step in which the air permeability of the hydrophobic filter is monitored, and a second step in which the hydrophobic filter is cleared by means of a connected air pump, if it is detected that the hydrophobic filter is clogged. An apparatus for performing this method includes a pressure sensor and an air pump connected to an air separation chamber via a conduit, and a control and monitoring unit configured to actuate the air pump in order to clear the hydrophobic filter.

Abstract: An ambulatory infusing device including a housing, a reservoir defining an interior volume, a wall associated with the housing and having an inner surface that faces into the reservoir interior volume, and a filter assembly. The filter assembly may include a filter assembly housing with a housing filter portion having a free end associated with the inner surface of the wall and a filter supporting volume that extends to the free end of the housing filter portion, and a filter located within the filter supporting volume that extends to at least the free end of the housing filter portion.

Abstract: Methods for operating an injection device that is mated to a mobile device are disclosed. Methods include sensing movements of the injection device and enabling inputs on the mobile device based on the movements of the injection device. Methods also include receiving desired injection parameter values into the mobile device, transmitting signals indicative of injection parameters from the mobile device to the injection device, activating injection of medicament with the injection device in accordance with the signals received from the mobile device, and obtaining data regarding the administered injection from the injection device.

Abstract: The present invention relates to a filtering injection needle assembly for a syringe, and more particularly, to an apparatus for further facilitating suction of an injection liquid. The filtering injection needle assembly includes an injection needle (100) including a needle (110) and a hub (120); and a cap (200) configured to receive the needle (110) and including a filter (210), wherein the hub (200) is formed with a through-hole (121) for communication between an inside and an outside of the hub, and opening/closing of the through-hole (121) is controlled by a one-way valve means (300). The filtering injection needle assembly blocks foreign substances introduced into the syringe, thereby enhancing safety, and wherein the filtering injection needle assembly has various types of one-way valve means provided in the hub of the injection needle to further facilitate the suction of the injection liquid.

Abstract: A method for readying a fluid sensor associated with a medical device includes attaching a flow restrictor to a fluid outlet of the fluid sensor. The fluid sensor includes a fluid channel, a fluid inlet at a first end of the fluid channel configured to couple to an outlet of an administrable fluid source, and the fluid outlet at a second end of the fluid channel. Fluid is delivered from the administrable fluid source to the fluid channel through the fluid inlet. A syringe actuation device including a force limiting device may be used to deliver the fluid. The fluid is pressurized in the fluid channel between the fluid inlet and the flow restrictor to wet an interior surface of the fluid channel with the fluid. The flow restrictor is removed from the fluid outlet.

Abstract: A pressure isolation mechanism including a valve housing which defines a first lumen associated with a pressurizing device, a second lumen associated with an input line which connects a low pressure fluid delivery system to the valve housing, and a pressure isolation port is disclosed. The pressure isolation mechanism further includes a first valve having a normally open position permitting fluid communication between the first lumen and the second lumen and movable to a closed position when fluid pressure in the first lumen reaches a predetermined pressure level, and a second valve disposed within the second lumen and regulating fluid flow through the second lumen, wherein the second valve substantially isolates the input line from a pressure transducer connected to the pressure isolation port. A method for correcting for dampened hemodynamic blood pressure signals in a fluid delivery system which includes the pressure isolation mechanism is also described.

Abstract: A cabinet structure for an infusion system includes a platform, on which the system is mounted, and a shell surrounding an interior space, which contains at least a portion of the system. The shell preferably includes an opening that is sized and oriented to allow a lowering of a radioisotope generator, for the system, into the interior space, and a lifting of the generator out from the interior space. The shell may further include another opening, located at a higher elevation than the aforementioned opening, in order to provide access to a waste bottle of the infusion system.

Abstract: A method of operating a disposable pumping unit includes enabling the disposable pumping unit to be loaded into a peritoneal dialysis hardware unit between a door and a housing of the hardware unit; structuring the disposable pumping unit to have a fluid pump receptacle, the fluid pump receptacle constructed and arranged to extend from both surfaces of the unit so as to fit within a first opening provided in the door and a second opening provided in the housing of the hardware unit; and enabling the disposable pumping unit to be guided into the hardware unit such that the fluid pump receptacle becomes aligned with the opposing first and second openings when the door is closed against the housing.

Abstract: Infusion systems and methods for infusing one or more drugs or other agents into the body of a human or animal subject. The system is programmed to take remedial action(s) upon sensing of a fault or error in connection with the infusion. In some embodiments, an agent may be infused through redundant flowpaths and, if a fault occurs in one flowpath, the system may respond by increasing flowrate through other non-faulting flowpath(s). In some embodiments, the fault may be a physiological reaction or symptom in the subject and the system may respond by adjusting or stopping flowrate(s) or one or more agents or changing the ratio of simultaneously infused agents.

Abstract: A medical instrument for ejecting liquid includes a liquid chamber that contains the liquid, a driving unit that pressurizes the liquid contained in the liquid chamber, and a vibration detector that detects vibration when the driving unit is driven.

Abstract: The present invention relates to an administration instrument for medical use that can perform injection of a drug solution with stability and with great reliability. For example, at the administration, it is possible to prevent a force that presses the injection button from acting in a direction of inserting the needle that is inserted into the skin deeper, and enables the administration under a stable state where the needle does not wobble, thereby alleviating physical and mental pain of the administration patient. With a structure in which an injection button (3) is pressed at an angle that is not parallel to the needle with respect to a direction in which the needle (4) is inserted into the skin, it is possible to prevent the force of pressing the injection button from being transmitted in a direction of inserting the needle into the skin deeper than the initial insertion of the needle, thereby achieving an administration under a stable state.

Abstract: A method of removing air from a flow path of a medical fluid injection system is described. An exemplary method performed by the medical fluid injection device includes delivering a first amount of fluid to a fluid flow path, isolating fluid flow along the flow path, forming a vacuum condition upstream of the fluid isolation, re-establishing fluid communications along the flow path, and delivering a second amount of fluid to the flow path.

Abstract: A wearable infusion pump assembly. The wearable infusion pump assembly includes a reservoir for receiving an infusible fluid and a fluid delivery system configured to deliver the infusible fluid from the reservoir to an external infusion set. The fluid delivery system includes a controller, a pump assembly for extracting a quantity of infusible fluid from the reservoir and providing the quantity of infusible fluid to the external infusion set, the pump assembly comprising a pump plunger, the pump plunger having distance of travel, the distance of travel having a starting position and an ending position, at least one optical sensor assembly for sensing the starting position and ending position of the pump plunger distance of travel and sending sensor output to the controller, and a first valve assembly configured to selectively isolate the pump assembly from the reservoir, wherein the controller receives the sensor output and determines the total displacement of the pump plunger.

Abstract: Bubble traps for removing bubbles from a stream of liquid and flexible containers comprising such bubble traps are disclosed. The bubble trap includes a containment chamber fluidly coupled to an outlet conduit. At least one grate is disposed between the containment chamber and the outlet conduit. The at least one grate includes a plurality of grate inlets formed in a grate wall and fluidly coupled to the outlet conduit with a plurality of grate conduits such that the containment chamber is fluidly coupled to the outlet conduit. The grate traps bubbles entrained in the stream of liquid flowing from the containment chamber to the outlet conduit in the containment chamber when the bubbles are greater than or equal to a diameter of the grate inlets.

Abstract: In general, this disclosure relates to techniques for automatically supplying a pressurizing unit (e.g., syringe) that is used with a powered medical fluid injection device with fluid. An example method performed by the medical fluid injection device includes obtaining operational state information of the medical fluid injection device, wherein the operational state information includes information other than a fluid delivery amount for a subsequent injection procedure. The example method further includes using the operational state information to determine whether the powered medical fluid injection device permits a fluid replenishment operation for the pressurizing unit. If the fluid replenishment operation is permitted, the method further includes automatically supplying the pressurizing unit with an amount of medical fluid. If the device includes multiple pressurizing units, the device may initiate an automatic fluid replenishment procedure for one or more of the pressurizing units during operation.

Abstract: The invention concerns an assembly for delivering a flowable nutritional substance, e.g. made from homemade cooked foods or home prepared food or foods treated with a hand blender or equivalent, comprising a substantially tubular container 1 formed with enclosed lower end and an open upper end, the open upper end being adapted to receive in a sealing manner a closure 20, the closure comprising a unidirectional valve 18, the container 1 also comprising a fluid outlet port in the form of a valve and a pump mechanism 3 is contained in a pump housing 5.

Abstract: A medical device pump with a housing with a compartment for removably receiving a cartridge containing a therapeutic agent, a conduit configured to operatively provide a fluid flow path for therapeutic agent to exit from the cartridge, a user activated delivery button, a trigger mechanism, and a pump mechanism employing an articulating, coiled drive spring.

Abstract: A system for controlled delivery of medicinal fluid includes a fluid pathway assembly defining a fluid pathway and including means for calculating a first calculated fluid flow rate using gas laws. The fluid pathway assembly has an inline flow sensor element received within the fluid pathway movable in response to fluid flowing in the fluid pathway. A flow control device is removably attached to the fluid pathway assembly and has a sensor for sensing a position of the inline flow sensor element in the fluid pathway, the position of the inline flow sensor element being representative of a second calculated fluid flow rate. The fluid pathway assembly includes a variable flow resistor adjustable to regulate a rate of fluid flow in the fluid pathway assembly. A drive mechanism attached to the flow control device is operably coupled to the variable flow resistor when the flow control device is attached to the fluid pathway assembly.

Abstract: An infusion pump system is described that increases patient comfort and convenience. The infusion pump system includes an infusion site interface that is releasably connected to an infusion pump body, and has no tubing associated between the infusion site interface and the pump body. The infusion pump body may include a carrier frame that may be adhered to the skin of a user.

Abstract: An infusion pump comprises at least three operating layers. A first layer includes epicyclic gear means comprising a rotatable central gear, a stationary outer ring gear, and movable planet gears arranged between the central gear and the ring gear in movable engagement with the central and ring gears. A second layer includes roller bearing means comprising a stationary outer ring and a movable inner roller arrangement in movable arrangement with the outer ring and coupled with the epicyclic gear means to provide a rotational bearing for the central and planet gears. A third layer includes rotary peristaltic pump means comprising stationary flexible tubing which includes a bent portion having an essentially part-cycle form and a rotor having engagement elements to squeeze the bent portion during rotation for a pump action, wherein the rotor is coupled with the central gear to transfer torque from the central gear to the rotor.

Abstract: An intravenous (“IV”) liquid delivery system includes: an IV pump tubing set; a shuttle pump or membrane pump actuator operable with the IV pump tubing set; upstream and downstream valve actuators operable with the IV pump tubing set; the IV pump tubing set including an air removal device; an air detector configured to sense air in the IV pump tubing set; a control unit configured and arranged to (i) open the upstream valve actuator and close the downstream valve actuator to allow the pump actuator to draw liquid into a pump actuation portion of the IV pump tubing set, and (ii) close the upstream valve actuator and open the downstream valve actuator to allow the pump actuator to push liquid out of the pump actuation portion, the system configured to attempt to remove the air via the air removal device while operating the upstream and downstream valve actuators according to (i) and (ii).

Abstract: An interventional catheter assembly comprising a catheter for insertion and guidance to a target site in a body lumen or a cavity and an operating head mounted in proximity to a distal end of the catheter and comprising a system for removing obstructive material from the target site is provided. In certain embodiments, the catheter assembly includes at least one aspiration port located proximal to the operating head that communicates with a first sealed lumen for withdrawing fluids and obstructive material from the target site, together with at least one liquid infusion port penetrating the catheter and located proximal to the at least one aspiration port that communicates with a second sealed lumen for supplying fluid to a location in proximity to the target site.

Abstract: An infusion pump device and method for filling a fluidic system of the infusion pump with liquid medicament prior to infusion operation is presented. A control unit causes the infusion pump to: (a) bring a pump to an initial state; (b) switch a valve to a first state connecting a secondary reservoir to a first conduit and a primary reservoir; (c) retrieve medicament from the primary reservoir; (d) switch the valve to a second state connecting the secondary reservoir to a second downstream conduit; (e) expel the secondary reservoir contents into the second downstream conduit; (f) switch the valve to the first state; (g) retrieve the primary reservoir medicament; (h) switch the valve to the second state; and (i) expel the secondary reservoir contents into the second downstream conduit by shifting a piston to the initial position.

Abstract: An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.

Abstract: A reservoir includes a reservoir body portion and a collecting portion. The reservoir body portion having a wall defining an interior volume for containing fluidic media, the reservoir having a first port in the reservoir body portion to be in fluid flow communication with the interior volume, the first port for expelling fluidic media from the interior volume as a plunger is moved within the reservoir. The collecting portion having a wall defining a volume in fluid flow communication with the interior volume, the volume of the collecting portion for collecting gas bubbles in the fluidic media as the fluidic media is expelled through the first port from the interior volume of the reservoir body portion, the reservoir having a second port in the collecting portion to be in fluid flow communication with the volume of the collecting portion, the second port for receiving fluidic media into the reservoir.

Abstract: A wearable infusion pump assembly. The wearable infusion pump assembly includes a reservoir for receiving an infusible fluid and a fluid delivery system configured to deliver the infusible fluid from the reservoir to an external infusion set. The fluid delivery system includes a controller, a pump assembly for extracting a quantity of infusible fluid from the reservoir and providing the quantity of infusible fluid to the external infusion set, the pump assembly comprising a pump plunger, the pump plunger having distance of travel, the distance of travel having a starting position and an ending position, at least one optical sensor assembly for sensing the starting position and ending position of the pump plunger distance of travel and sending sensor output to the controller, and a first valve assembly configured to selectively isolate the pump assembly from the reservoir, wherein the controller receives the sensor output and determines the total displacement of the pump plunger.

Abstract: A method of removing air from a flow path of a medical fluid injection system is described. An exemplary method performed by the medical fluid injection device includes delivering a first amount of fluid to a fluid flow path, isolating fluid flow along the flow path, forming a vacuum condition upstream of the fluid isolation, re-establishing fluid communications along the flow path, and delivering a second amount of fluid to the flow path.

Abstract: Various embodiments of the present invention are directed to limiting a presence of air bubbles in a fluidic medium expelled from a reservoir. In various embodiments, a reservoir is shaped so as to limit a presence of air bubbles in a fluidic medium expelled from the reservoir. Also, in various embodiments, a plunger head within a reservoir is shaped so as to limit a presence of air bubbles in a fluidic medium expelled from the reservoir. In some embodiments, both a reservoir and a plunger head within the reservoir are shaped so as to limit a presence of air bubbles in a fluidic medium expelled from the reservoir.

Abstract: Embodiments directed to a degassing device for removing gas bubbles from a liquid drug stream and an ambulatory infusion system are disclosed. The degassing device may comprise an inlet chamber with an inlet opening, an outlet chamber with an outlet opening, and a degassing opening. A hydrophilic membrane and a hydrophobic membrane, wherein the hydrophilic membrane fluidically couples the inlet chamber with the outlet chamber, enabling a transfer of liquid from the inlet chamber to the outlet chamber. The hydrophobic membrane fluidically couples the inlet chamber with the degassing opening, enabling a transfer of gas from the inlet chamber to the degassing opening. The hydrophilic and hydrophobic membranes being joined along a joint to establish a joined membrane, such that a contact line of a liquid-gas phase separation on the joined membrane does not coincide with the joint independent of an orientation of the degassing device with respect to gravity.

Abstract: An auto purge for an intravenous contrast injector of the type having a motor which advances a plunger drive ram and configured for use with a pre-filled or user-filled syringe containing an approximate known amount of air including a processor which causes the motor to move and a memory storing a predetermined purge stop point representative of the approximate known amount of air in the syringe, the injector configured to automatically advance the plunger drive ram an amount substantially equal to the predetermined purge stop point representative of the approximate known amount of air contained in the syringe.

Abstract: An infusion pump system is described that increases patient comfort and convenience. The infusion pump system includes an infusion site interface that is releasably connected to an infusion pump body, and has no tubing associated between the infusion site interface and the pump body. The infusion pump body may include a carrier frame that may be adhered to the skin of a user.

Abstract: An intravenous pump system includes an intravenous pump having an air bubble detector, a separate air trap module and a patient line. The air trap module is connectable to a set interface upon which the pump can operate. The air trap module includes an air chamber capable of receiving fluids and air, a plurality of valves controlling the flow of the fluids and air, and an air vent. The patient line is connectable to the air trap module and to a patient. The air trap module includes an actuator to control the state of the valves to enable, at least during a venting mode, the pump to push air out of the air chamber via the vent without disconnecting the patient from the patient line.

Abstract: An infusion pump system is described that increases patient comfort and convenience. The infusion pump system includes an infusion site interface that is releasably connected to an infusion pump body, and has no tubing associated between the infusion site interface and the pump body. The infusion pump body may include a carrier frame that may be adhered to the skin of a user.

Abstract: Apparatus and methods for inhibiting the introduction of air into the body during a percutaneous procedure.

Abstract: In various embodiments, a tool is employed in filling a drug-delivery device. The tool may include, for example, a needle that is admitted through a fill port of the drug-delivery device.

Abstract: System for detecting and removing gas bubbles from a vascular infusion line, including a cassette adapted for disposition intermediate the fluid line, the cassette including a flexible tube having an inlet port for connection to a supply side of the fluid line, an outlet port configured for connection to a patient side of the fluid line, and a purge port intermediate the inlet and outlet ports, and a base unit adapted to receive the cassette and monitor fluid flow through the tube, the base unit including a sensor to detect the presence of a gas bubble in the fluid flow, a pinch valve adapted to stop the flow of fluid, and a control unit adapted to operate the base unit so that (i) fluid is permitted to flow past the pinch valve when no gas bubble is detected; and (ii) fluid flow is arrested when a gas bubble is detected.

Abstract: In general, this disclosure relates to techniques for sealing, or pinching, high-pressure fluid tubing (e.g., braided tubing) that may be used to deliver medical fluid from a powered medical fluid injection device, such as an injector that delivers contrast media and/or saline during angiographic or computed tomography (CT) procedures. In some cases, one or more low-friction, solenoid-based pinch valve mechanisms may be used. One example powered medical fluid injection device comprises an injector head and at least one pinch valve mechanism that is coupled to the injector head. The at least one pinch valve mechanism comprises a plunger, a reciprocating arm driven by the plunger, and a tube pinching area. The at least one pinch valve mechanism, when deactivated by the injector head, is configured to cause the reciprocating arm to pinch fluid tubing that runs through the tube pinching area.

Abstract: A multi-channel peristaltic pump in which each channel can be operated independently of the others. A peristaltic pump includes a plurality of motors, each of which drives a rotor shaft which is independently rotatable around an axis and which rotates a roller head having a plurality of rollers. The rotor shafts are disposed in a concentric manner. The peristaltic pump further can include a control system allowing an operator to selectively determine the speed and direction of rotation of each of the roller heads of the pump.

Abstract: In an infusion circuit (1), a peristaltic pump (7) displaced the infusion fluid along a line (3), sourcing it from a batch container (2). When a weight sensor (5) detects an emptying of the batch container (2), the pump is halted. If on stopping the pump the pressure measured by a sensor (6) operating in an expansion chamber (4) does not drop in excess of a predetermined threshold with respect to a non-empty container (2), a non-secure situation is signalled, due to an excessive quantity of air in the expansion chamber.

Abstract: An intravenous (“IV”) liquid delivery system includes: an IV pump tubing set; a shuttle pump or membrane pump actuator operable with the IV pump tubing set; upstream and downstream valve actuators operable with the IV pump tubing set; the IV pump tubing set including an air removal device; an air detector configured to sense air in the IV pump tubing set; a control unit configured and arranged to (i) open the upstream valve actuator and close the downstream valve actuator to allow the pump actuator to draw liquid into a pump actuation portion of the IV pump tubing set, and (ii) close the upstream valve actuator and open the downstream valve actuator to allow the pump actuator to push liquid out of the pump actuation portion, the system configured to attempt to remove the air via the air removal device while operating the upstream and downstream valve actuators according to (i) and (ii).

Abstract: An infusion pump system is described that increases patient comfort and convenience. The infusion pump system includes an infusion site interface that is releasably connected to an infusion pump body, and has no tubing associated between the infusion site interface and the pump body. The infusion pump body may include a carrier frame that may be adhered to the skin of a user.

Abstract: An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.