Abstract: A system for the metering and delivery of small discrete volumes of liquid is comprised of a small or minimal number of inexpensive components. One such component is a movable member, such as a miniature precision reciprocating displacement pump head, which is driven by an actuator that comprises a shape memory alloy material. The operating mechanism of the system is of little or minimal complexity. The system facilitates the precise metering and delivery of the small discrete volumes of liquid. Potential applications for the system include subcutaneous, long-term, automated drug delivery, for example, the delivery of insulin to a person with diabetes. In such an application, the small, simple and inexpensive nature of the invention would allow for its use as both a portable and a disposable system.

Abstract: A fluid ejection system (20) comprising a cartridge (24), an ejector (32, 300) and, optionally, a fill station (28) for filling the cartridge with a fluid, such as a vaccine. In some embodiments (52), the cartridge includes a transfer passageway (96) for receiving fluid from the fill station. In other embodiments (200, 400), the cartridge includes a vented fluid reservoir (208, 408) offset from an ejection chamber (224, 420). In yet other embodiments (500, 600), the cartridge includes a vented fluid reservoir chamber (512, 636) inline with the ejection chamber (508, 644). In still other embodiments (700, 1000, 1100), the cartridge includes first and second chambers (728, 736, 1036, 1048, 1136, 1148) initially fluidly sealed from on another by a valve, e.g., either a traveling valve (704, 800, 900, 1200, 1300) or a temporarily stationary valve (1004, 1104).

Abstract: A medical pump includes a chassis having a fixed seat, and a main carriage having a carriage footing for receiving a fluid delivery device and restricting its movement. An actuator automatically moves the main carriage between open and closed positions to engage the fluid delivery device to the seat. The seat establishes the position of both the main carriage and fluid delivery device in the closed position. The actuator is connected to the main carriage by a rear carriage assembly having a manual release element for disengaging the actuator from rear carriage assembly and thereby from the main carriage. A processing unit detects jam conditions by processing carriage position data and electrical load data from the actuator.

Abstract: A medical liquid injection system capable of automatically preventing a piston drive mechanism from being driven when a cylinder holding mechanism does not hold a medical liquid syringe properly. When a cylinder member (210) is being held, in a specific direction of rotation about the axis of the mechanism, by a cylinder holding mechanism (120), an RFID chip (230) and an RFID reader (131) become communicable, making the piston drive mechanism operable. On the other hand, when the cylinder member (210) has been rotated by a specified angle from a specific direction, the RFID chip (230) and the RFID reader (131) become incommunicable, not making the piston drive mechanism operable. As a consequence, the piston drive mechanism is not driven when the cylinder holding mechanism (120) is not holding the medical liquid syringe properly.

Abstract: A system for the metering and delivery of small discrete volumes of liquid is comprised of a small or minimal number of inexpensive components. One such component is a movable member, such as a miniature precision reciprocating displacement pump head, which is driven by an actuator that comprises a shape memory alloy material. The operating mechanism of the system is of little or minimal complexity. The system facilitates the precise metering and delivery of the small discrete volumes of liquid. Potential applications for the system include subcutaneous, long-term, automated drug delivery, for example, the delivery of insulin to a person with diabetes. In such an application, the small, simple and inexpensive nature of the invention would allow for its use as both a portable and a disposable system.

Abstract: A system for the metering and delivery of small discrete volumes of liquid is comprised of a small or minimal number of inexpensive components. One such component is a movable member, such as a miniature precision reciprocating displacement pump head, which is driven by an actuator that comprises a shape memory alloy material. The operating mechanism of the system is of little or minimal complexity. The system facilitates the precise metering and delivery of the small discrete volumes of liquid. Potential applications for the system include subcutaneous, long-term, automated drug delivery, for example, the delivery of insulin to a person with diabetes. In such an application, the small, simple and inexpensive nature of the invention would allow for its use as both a portable and a disposable system.

Abstract: A system for the metering and delivery of small discrete volumes of liquid is comprised of a small or minimal number of inexpensive components. One such component is a movable member, such as a miniature precision reciprocating displacement pump head, which is driven by an actuator that comprises a shape memory alloy material. The operating mechanism of the system is of little or minimal complexity. The system facilitates the precise metering and delivery of the small discrete volumes of liquid. Potential applications for the system include subcutaneous, long-term, automated drug delivery, for example, the delivery of insulin to a person with diabetes. In such an application, the small, simple and inexpensive nature of the invention would allow for its use as both a portable and a disposable system.

Abstract: A system for the metering and delivery of small discrete volumes of liquid is comprised of a small or minimal number of inexpensive components. One such component is a movable member, such as a miniature precision reciprocating displacement pump head, which is driven by an actuator that comprises a shape memory alloy material. The operating mechanism of the system is of little or minimal complexity. The system facilitates the precise metering and delivery of the small discrete volumes of liquid. Potential applications for the system include subcutaneous, long-term, automated drug delivery, for example, the delivery of insulin to a person with diabetes. In such an application, the small, simple and inexpensive nature of the invention would allow for its use as both a portable and a disposable system.

Abstract: A plunger head moveable in an axial direction within a reservoir having an interior volume for containing fluidic media may have a first portion in contact with fluidic media when fluidic media is in the interior volume of the reservoir, the first portion comprising a first material compatible with fluidic media in the interior volume of the reservoir, a second portion located on an opposite side of the plunger head from the interior volume of the reservoir, the second portion connectable to a plunger arm, and a third portion located between the first portion and the second portion of the plunger head, at least one of the first portion, second portion, and the third portion is made of a material that comprises one of a cyclic olefin copolymer and a cyclic olefin polymer.

Abstract: A syringe pump has a motor rotating a leadscrew, which drives a plunger head retainer to push a plunger along the barrel of a syringe so as to dispense medication to a patient. A force sensor in the head retainer measures the force on the plunger to detect when there is an occlusion restricting flow of medication. When an excess force is detected an alarm is generated and the motor is reversed to reduce the force to about 10% of that at which the occlusion is detected. The occlusion can be removed with a reduced risk of a bolus of medication being dispensed after which the user restarts the pump so that the plunger is driven normally.

Abstract: A heart pump has a pump chamber and a pump element that strokes between a retracted and an extended position. A motor rotates a drive shaft in a single direction. A reversing mechanism coupled between the drive shaft of the motor and the pump element converts rotary motion of the drive shaft to reciprocal stroking movement of the pump element. A mechanical stroke length controller connected to the reversing mechanism varies the stroke length in response to changes in fluid pressure in the pump chamber.

Abstract: The filling of a syringe can be performed at a faster rate using a filling sequence which expels air from the fill tube before filling the syringe. A similar method is used when changing contrast containers during a filling sequence to ensure that all the air is expelled from the fill tube before filling resumes with the new contrast container. Additionally, by including a contrast container holder that is affixed to an injector head and holds the container near the syringe tip, the filling sequence can be accomplished without requiring the operator to hold the contrast container during the sequence.

Abstract: A reservoir and a plunger head contained within may be configured to move relative to each other in response to at least one of the reservoir being detached from a base, the base and/or the reservoir being removed from a packaging, and the base and/or the reservoir being moved relative to each other. A first layer may be configured to define a reservoir, the first layer, which may be made of a material compatible with fluidic media in the reservoir, may be adjacent a second layer for inhibiting a diffusion through the second layer. A first layer that may be less than 0.3 mm and made of a cyclic olefin copolymer may be configured to define a reservoir. A reservoir may be defined by a wall made of a cyclic olefin copolymer and the wall may be for substantially preventing light from passing through the reservoir.

Abstract: A syringe includes a body having a distal end, a proximal end and a center section therebetween. The distal end of the syringe body includes a conical portion that extends and tapers from the center section to an injection neck forming a discharge outlet. The proximal end of the syringe body includes a radial expansion section and an outward extending lip. An inner diameter of the radial expansion section is larger than an inner diameter of the center section and the outer diameter of the radial expansion section is smaller than an outer diameter of the center section. A plunger is movably disposed in the syringe body and includes a pair of coupling members defining a slot therebetween, the plunger being substantially seated in the radial expansion section in a pre-use state of the syringe. An alignment flange is formed on the conical portion and extends the distance between the center section and the injection neck.

Abstract: A micro fluid delivery device is particularly useful in medical applications. The device may be worn or carried by the user and may deliver drugs or other medicaments to the user or patient. The device has a control system that accepts input from the user and controls all aspects of operation of the device. The control system measures the output of the pump and adjusts the output of the pump to achieve the desired dosage rate and size. This eliminates differences from pump to pump that result from inevitable variations in the manufacturing of such small scale affordable devices.

Abstract: A micro fluid delivery device is particularly useful in medical applications. The device may be worn or carried by the user and may deliver drugs or other medicaments to the user or patient. The device has a control system that accepts input from the user and controls all aspects of operation of the device. The control system measures the output of the pump and adjusts the output of the pump to achieve the desired dosage rate and size. This eliminates differences from pump to pump that result from inevitable variations in the manufacturing of such small scale affordable devices.

Abstract: Embodiments of an injector, syringe, syringe interface, syringe adapter, and piston/plunger assembly for an injector (of contrast medium, for example) are described. Preferably, the syringe is adapted to engage a syringe interface mechanism such that the syringe may be connected to an injector without regard to any particular orientation of the syringe to the injector or to the piston/plunger assembly. The injector piston or drive member includes a sensing pin positioned at a forward end thereof to sense contact with the syringe plunger during advancement of the piston or drive member to contact the plunger. The piston can be advanced automatically upon connection of, for example, the syringe to the injector, or piston advance can be automated to occur after operator initiation. The injector may include or be adapted to accommodate two syringes, which for example provide for simultaneous injection of fluid into separate injection sites on a patient.

Abstract: An aspirator cassette includes a housing having first and second ends sealed off by first and second end caps, respectively. A partition mechanism is enclosed within the housing for dividing its internal volume into first and second regions. First and second fluid flow ports are mounted on the first and second end caps, respectively, to provide fluid flow paths into and from the first and second regions, respectively. When the first region is filled with liquid, its associated first port is connected to a vacuum source for sucking the liquid out of the region, whereby as the liquid is removed, the partition mechanism responds by decreasing the volume of the first region, and increasing the volume of the second region causing its second port to draw a vacuum for sucking fluid from an aspiration device connected to the second port.

Abstract: A pump including a stator, a rotor comprising an axial extension slidably and rotatably mounted at least partially in a rotor chamber of the stator, and at least first and second valves between an inlet and the rotor chamber, respectively between the rotor chamber and an outlet, that open and close as, a function of at least the angular displacement of the rotor. The pump comprises interacting cam elements on the rotor and stator and biasing means acting on the rotor for applying a force on the rotor in the axial direction of the stator cam element.

Abstract: A system and method for mixing and delivering fluids such as contrast media and saline is disclosed including at least two fluid sources, a pump, a joining fluid path connecting the at least two fluid sources to an inlet to the pump, and a valve device in the fluid path upstream of the pump. The valve device includes an actuator adapted to restrict flow in at least one of respective fluid lines connecting the at least two fluid sources to the pump inlet. A patient interface device may be associated with an outlet of the pump. The valve device actuator is generally adapted to restrict the flow in at least one of the respective fluid lines such that an incremental positional change in valve device actuator position provides a substantially linear change in fluid mixture ratio of the fluids from the at least two fluid sources to the pump inlet.

Abstract: A drug delivery pump drive which uses a linear piezoelectric motor to advance a syringe piston to deliver a liquid drug and a method thereof are disclosed. The pump drive, provided in a drug delivery pump, provides silent operation and very low energy consumption compared to electric motor-based drives. The small size of the motor helps also to reduce overall size of the pump drive and the resulting drug deliver pump.

Abstract: A wearable infusion device comprises a first control movable between a first position and a second position that when in the first position, establishes a first fluid path between a reservoir and a pump and when in the second position, establishes a second fluid path between the pump and an outlet. A second control actuates the pump only when the second fluid path has been established by the first control.

Abstract: A medical fluid machine includes a housing providing a first wall and a second wall, the first and second walls at least partially defining a pump chamber. A fluid receptacle is located within the pump chamber, the fluid receptacle including first and second flexible membranes configured to be moved apart to accept a medical fluid and moved together to dispel the fluid. A medical fluid outlet is in communication with the fluid receptacle. A first valve arrangement is configured to enable medical fluid in a sufficiently air-free condition to be delivered from the receptacle through the medical fluid outlet to a patient. A second valve arrangement is configured to enable medical fluid with entrained air to be delivered instead from the receptacle through the medical fluid outlet to an entrained air destination.

Abstract: The present invention provides a fluid pump for medical applications. The invention comprises a flexible cassette containing two pump chambers, wherein the first pump chamber is larger than the second pump chamber. The pump includes two pistons, one for each pump chamber. The first piston pushes fluid from the first chamber to the second, and the second piston pushes fluid from the second chamber downstream out of the pump. Three valves are coordinated with the action of the pistons to control fluid flow into and out of the pump chambers by applying and releasing pressure to and from specific points of the flexible cassette. A control system controls the operation of the pistons and valves and directs the pistons to be advanced according to a time-varying velocity profile. The first pump chamber passively fills and then rapidly expels the collected fluid into the second chamber at low pressure.

Abstract: A syringe interface is provided for attaching a syringe to an injector. The syringe includes, a first and second set of generally opposing, radially outward projecting mounting flanges, and a second set of flanges offset from the first set of mounting flanges. The syringe interface includes a first set of generally opposed slots adapted to receive therethrough the first set and second set, respectively, of mounting flanges, and a first and second set of generally opposed retaining flanges adapted to releasably engage the first and second set respectively, a set of mounting flanges, when the syringe is rotated within the syringe interface.

Abstract: An ambulatory infusion device including a fluid transfer device with a piston bore and a piston. The piston bore surface and the piston surface are configured such that they will wear at a very slow rate when cycled in the absence of a lubricant other than the infusible substance.

Abstract: In one embodiment, a volumetric pump in a medical fluid delivery system comprises at least one piston in a hollow cylinder, the pump having at least one inlet port through which a medical fluid can be sucked into a pump chamber during an instroke of said piston, and at least one outlet port through which the medical fluid can be expelled during an outstroke of the piston. The piston or the hollow cylinder can be actuated directly or indirectly by a rotor. This rotor transmits on the one hand a bi-directional linear movement to the piston or to the cylinder and on the other hand, a bi-directional angular movement either to the piston or to another ratable element in order to open and close alternately the inlet and outlet ports.

Abstract: A piston adapter has a flange holding mechanism mounted on a distal end thereof for releasably holding a piston flange of a piston of a rodless syringe, a manual operating member disposed on a tip end of the piston adapter for being manually operated, and an interlink mechanism for releasing the flange holding mechanism from the piston flange in conjunction with manual operation of the manual operating member. After the piston adapter is mounted on the piston of the rodless syringe and inserted into the cylinder thereof, the flange holding mechanism can be released from the piston in the cylinder by manually operating the manual operating member near the tip end of the piston adapter which is exposed from the cylinder. Even when the piston adapter that is mounted on the piston of the rodless syringe is pressed into the cylinder, the piston adapter can easily be removed from the rodless syringe.

Abstract: Sensors are described that may be provided in a medication pump. A light sensor may be provided that detects if a cartridge is present in a cartridge chamber. A medication cartridge includes an opaque area at its open end for use with the light sensor.

Abstract: A highly reliable and robust functioning liquid infusion system for use in biomedical applications comprises a dual microcontroller system where the first microcontroller is configured to administer the liquid and the second microcontroller is configured to monitor the accurate functioning of the system and various performance parameters such as flow rate of liquid, presence of leaks or blocks in the liquid passage, level of drug in the cartridge and battery condition. The liquid injection portion comprises a cylindrical airtight liquid holder or drug cartridge with a movable internal piston that is in contact with a movable stem, and a micromotor, which controls the drug delivery. The system is programmable with a dosing system stored into the driver/monitor microcontrollers. A low power LCD module is used to display the operating parameters with multiple language interface and alarm conditions, if any.

Abstract: The invention provides a pump assembly comprising a suction pump and a safety valve arranged between the pump inlet and a fluid inlet for the assembly. The safety valve comprises an inlet valve and a moveable control member acting on the safety inlet valve, wherein the control member is operatable between an initial position in which the safety inlet valve is closed, and an activated position in which the safety inlet valve is open, and wherein the control member is moved from the initial to the activated position by means of suction action from the pump. By this arrangement the opening of the safety valve is positively controlled by the suction provided by the pump whereas the safety valve is closed during non-operation of the pump.

Abstract: A drive mechanism for delivery of infusion medium a coil capable of being electrically activated to provide an electromagnetic field. The coil surrounds a piston channel extending in an axial direction. The piston channel provides a passage for communication of infusion medium to an outlet chamber located at one end of the piston channel. An armature is located adjacent the coil, on one side of the axial channel. The armature is moveable toward a forward position, in response to the electromagnetic field produced by activation of the coil. A piston is located within the piston channel and is moveable axially within the channel to a forward position, in response to movement of the armature to its forward position. The armature and piston are moved toward a retracted position, when the coil is not energized. In the retracted position of the piston, a piston chamber is formed between the piston and a valve member and is filled with infusion medium.

Abstract: A chemical liquid injection system which a piston driving mechanism is driven only when a cylinder holding mechanism appropriately holds liquid syringes of various sizes through a cylinder adapter and such manner. When the liquid syringe 200S of a size other than the maximum size is appropriately held by the cylinder holding mechanism 120, RFID chip 230 is located on the side at the rear of metallic cylinder holding mechanism 120. A pair of resonance antennas are disposed on the left and right of the RFID chip, and an RFID reader 131 is disposed below the resonance antennas. When the liquid syringe 200S is appropriately held by the cylinder holding mechanism 120, RFID chip 230 wirelessly communicates with RFID reader 131 favorably, and the piston driving mechanism can be operated only in this state.

Abstract: A delivery device includes a durable housing portion and a separable disposable portion that selectively engage and disengage from each other. The disposable housing portion secures to the patient-user and may be disposed of after it has been in use for a prescribed period. Components that normally come into contact with a patient-user or with an infusion medium, including a pump device, are supported by the disposable housing portion for disposal after the prescribed use, while the durable housing portion supports other components such as electronics for controlling delivery of the infusion medium from the reservoir and a drive device and drive linkage.

Abstract: Disclosed is a portable device for delivering a medicament or the like into the body of a human or animal subject, the device comprising: a medicament compartment containing the medicament or the like to be delivered; delivery means comprising an orifice through which the medicament or the like is expelled from the device; and an internal combustion engine which provides the motive force by which the medicament is expelled from the device.

Abstract: A delivery device for patient-controlled infusion of a medicament, the delivery device comprising a reservoir for the medicament and a pump having a predetermined delivery dose which is capable of displacing the medicament from the reservoir and delivering it to a patient, wherein the pump comprises a pumping means, a first conduit, capable of restricting flow rate, chosen in conjunction with the delivery dose of the pumping means to define a predetermined maximum dosage rate, said conduit connecting the reservoir to a pumping means, a one-way valve in fluid communication with the first conduit and the pumping means which permits medicament flow into the pumping means but prevents reverse flow, a controlling means, and a second conduit extending from the pumping means and having a distal end through which the medicament may be released, wherein the controlling means: (a) is in fluid communication with the pumping means and the second conduit; (b) opens when pressured within the dose chamber exceeds a predeter

Abstract: The present invention relates to a piston pumping system for substantially gas-free measurement and/or pumping of predetermined quantities of liquids, preferably pharmaceutical liquids containing oxidation-prone ingredients. Preferably, the system is used as a micropump or as a component thereof in medical devices such as transdermal therapeutic systems, for example.

Abstract: A piston-type drive mechanism in combination with a positive pressure reservoir for delivery of infusion medium. A coil capable of being electrically activated to provide an electromagnetic field. The coil surrounds a piston channel extending in an axial direction. The piston channel provides a passage for communication of infusion medium from the positive pressure reservoir to an outlet chamber. A piston is located within the piston channel and is moveable axially within the channel to a forward position. The piston is moved toward a retracted position, when the coil is not energized. As the piston is moved to its forward position, pressure moves a valve member into an open position. When the valve member is in the open position, medium from the piston chamber is discharged into the outlet chamber. An outlet is provided in flow communication with the outlet chamber, for discharging infusion medium from the outlet chamber.

Abstract: The fluid injection apparatus includes a syringe, an injector, and a pressure jacket. The syringe has a cylindrical body with an injection section at a distal end and a plurality of outward extending retaining flanges at a proximal end. The injector has an injector housing defining a central opening and an injector drive piston extendable through the central opening for imparting motive forces to a syringe plunger disposed within the syringe. The pressure jacket secures the syringe during an injection procedure. The pressure jacket has a wall defining a plurality of longitudinally extending grooves in an inner surface thereof configured to receive the retaining flanges of the syringe. The grooves cooperate with a plurality of transversely extending slots defined in the inner surface of the pressure jacket wall. The engagement of the retaining flanges in the slots via the grooves secures the syringe in the pressure jacket.

Abstract: A drive mechanism for delivery of infusion medium. A coil surrounds a piston channel. An armature is located adjacent the coil. The armature is moveable toward a forward position in response to the electromagnetic field produced by activation of the coil. A piston located within the piston channel is moveable within the channel to a forward position in response to movement of the armature. The armature and piston are moved toward a retracted position when the coil is not energized. In the retracted position, a piston chamber formed between the piston and a valve member is filled with infusion medium. As the piston is moved to its forward position, piston chamber volume is reduced and pressure within the piston chamber increases and moves the valve member into an open position. Medium from the piston chamber is then discharged into an outlet chamber.

Abstract: A fluid pump for pumping fluid. The fluid pump includes a driver having a substantially tubular shaped body defining a body axis and, a number of elements circumferentially spaced around the body. Each element is responsive to a signal to so as cause a corresponding portion of the body to expand or contract in a direction substantially parallel to the tube axis. The pump also includes an urging member positioned in a flow path. In use, the urging member is coupled to the driver such that selective expansion and/or contraction of the body causes the urging member to rotate, thereby urging fluid along the flow path.

Abstract: An injector system includes an injector and a syringe. The injector includes a housing having a front wall, a drive member moveable through the front wall of the housing, and a pressure jacket assembly for operably associating the syringe with the housing. The pressure jacket assembly includes a rearward end mounted on the front wall of the housing and a forward open end for receiving the syringe therethrough. The syringe includes a body having a main section, a conical section in fluid communication with the main section and a fluid discharge section in fluid communication with the conical section. The syringe further includes a plunger movably disposed in the body. The plunger includes one or more hook members extending rearward from the plunger for connecting the plunger to the drive member of the injector. The syringe also includes a protrusion for facilitating handling of the syringe. Preferably, the protrusion is operably associated with and extends forwardly from the conical section of the body.

Abstract: An animal fluid injector, replaceable syringe and method of replacement of the syringe in the injector are provided in which the syringe is loadable and unloadable into and from the injector through the open front end of a pressure jacket of the injector, thereby permitting replacement without retraction of the syringe plunger drive or disconnection of the injection tubing. The syringe is provided with a pressure restraining front end, such as an integral or removable cap with structure such as threads that lock the syringe to the front end of the jacket by mating with threads on the jacket. A mechanism in the injector, which includes, for example, a key on cam ring operated by a lever with one hand of an operator, interacts with structure such asymmetrically spaced notches on the back end of the syringe to, for example, rotate the syringe and simultaneously translate or rotate a coupling on the syringe plunger into and out of engagement with the plunger drive in the injector.

Abstract: A pump for dispensing a fluid from a reservoir provides a drive system seal within the pump. The pump includes a reservoir cavity adapted to receive the reservoir, and a drive system. The pump also includes at least one plunger slider having one end coupled to the drive system and the other end coupled to the reservoir. The plunger slider is adapted to translate from a retracted position to an extended position to dispense the fluid from the reservoir in response to actuation by the drive system. The pump further includes a sealing ring mounted around the plunger slider, and a spring disposed within the sealing ring. The sealing ring with the spring disposed therein is adapted to allow the plunger slider to translate from the retracted position to the extended position, and to prevent entry of fluid from the reservoir cavity into the drive system.

Abstract: Apparatuses and methods for pumping fluid are disclosed. An exemplary apparatus is a miniature pump that includes a shape memory wire that obtains a plastic condition below a transformation temperature and has a memorized shape such that the shape memory wire produces a work stroke by returning to the memorize shape at least at the transformation temperature. A spring biased against the shape memory wire is deflected by the work stroke to deform the shape memory wire from the memorized shape below the transformation temperature. A fluid pump is coupled to the shape memory wire and driven by the biased spring and shape memory wire to produce a fluid flow. The miniature pump can be incorporated into a self-contained infusion device in the form of a compact self-adhesive patch including a fluid reservoir, control electronics and power supply that is place directly at the infusion site of a user.

Abstract: A transdermal electrotransport drug delivery device having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. At least one of the anode and the cathode includes an electrode and a reservoir comprised of a housing composed of a polymeric material and an aqueous medium in contact with the housing. The aqueous medium includes (i) a drug or an electrolyte salt or a mixture thereof, (ii) propylene glycol, and (iii) an antimicrobial agent in an amount sufficient to inhibit microbial growth in the aqueous medium. The propylene glycol prevents the antimicrobial agent from being adsorbed by other materials used in the construction of the delivery device. A process for preparing a transdermal electrotransport drug delivery device is also provided.

Abstract: The present invention concerns a medication pump, a cartridge for use in a medication pump, a pump cap for use with a medication pump, components of the cartridge and methods of use of these devices. A cartridge includes a plunger having a tab that projects from an interior wall of the plunger. The tab can be used to lock the plunger into engagement with a drive rod of the pump. The drive rod defines a channel for receiving the tab of the plunger, where the channel includes an axial portion disposed parallel to an axis of the drive rod and a locking portion disposed in a circumferential direction around an outer surface of the drive rod. A similar channel structure can be provided on a removable fill rod used while filling the cartridge. The cartridge axially inserted into a cartridge chamber and then is rotated into engagement with the drive rod. The cartridge may also include axial guides at one end that interface with a guides on pump cap.

Abstract: A syringe adapter, which permits use of syringes of various types and sizes to be used with a front-loading injector, includes a piston extension and an adapter face plate. The piston extension includes structure for connecting the piston extension to a drive piston of the injector and a plunger of the syringe. The adapter face plate includes a mounting device for attaching the adapter face plate to an injector and a recess for receiving the distal flange of the syringe. The adapter face plate may also include locking pivot arms for releasably engaging the syringe flange.

Abstract: A drive mechanism for delivery of infusion medium has a coil and an armature moveable toward a forward position, in response to the electromagnetic field produced by activation of the coil. A piston is moveable axially within a piston channel to a forward position, in response to movement of the armature to its forward position. The armature and piston are moved toward a retracted position, when the coil is not energized. In the retracted position of the piston, a piston chamber is formed between the piston and a valve member and is filled with infusion medium. As the piston is moved to its forward position, the piston chamber volume is reduced and pressure within the piston chamber increases to a point where the pressure moves the valve member into an open position through an outlet.

Abstract: A medical device is provided having a needle or a catheter, insertable into a living body, which defines a plurality of holes in fluid communication with a central lumen. The holes may be of various patterns located and angled to create a desired injectate cloud pattern when an injectate is forced through the central lumen and through the plurality of holes. One embodiment provides various designs including a moveable sheath or stylet used to selectively occlude one or more of the holes while in use, thereby providing an operating physician a way to manipulate the cloud pattern anytime during the introduction of the injectate. A reducer may be used in conjunction with these needles which provides an increased degree of control when injecting very small quantities of fluid.